Shimmura Shigeto 榛村重人

… Alternative Names

SHIMMURA Shigeto 榛村重人

Shimmura Shimmura 榛村重人

榛村重人シンムラシゲト

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Researcher Number	00235780
Other IDs
Affiliation (Current)	2023: 慶應義塾大学, 医学部(信濃町), 特任教授 2023: 藤田医科大学, その他部局等, 教授 2023: 東京歯科大学, 歯学部, その他
Affiliation (based on the past Project Information) *help	2021 – 2022: 慶應義塾大学, 医学部(信濃町), 准教授 2018 – 2019: 慶應義塾大学, 医学部(信濃町), 准教授 2017: 慶應義塾大学, 医学部, 講師 2016: 慶應義塾大学, 医学部(信濃町), 准教授 2016: 慶應義塾大学, 医学部, 准教授 … More 2014: 慶應義塾大学, 医学部(信濃町), 准教授 2008 – 2014: 慶應義塾大学, 医学部, 准教授 2011: 慶應義塾大学, 医学部 2005 – 2006: 東京歯科大学, 歯学部, 客員講師 2000 – 2001: 東京歯科大学, 歯学部, 講師 1996: 慶應義塾大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Ophthalmology / Ophthalmology / Basic Section 56060:Ophthalmology-related Except Principal Investigator Ophthalmology
Keywords	Principal Investigator 角膜上皮細胞 / 再生医療 / 紫外線 / 酸化ストレス / 幹細胞 / 角膜内皮細胞 / 角膜 / フリーラジカル / ラクトフェリン / 鉄 … More / 抗酸化剤 / 蛍光色素 / ヘムオキシゲナーゼ / アポトーシス / カスパーゼ / ネクローシス / 抗酸化物質 / ミトコンドリア / Hypoxia inducible factor(HIF) / 低酸素培養 / Hypoxia inducible factor (HIF) / 細胞周期 / 増殖 / Hyoxia inducible factor (HIF) / 分化 / 角膜内皮 / 皮膚幹細胞 / 神経堤細胞 / 水疱性角膜症 / 角膜移植 / 皮膚由来幹細胞 / 低酸素 / 細胞培養 / サイトケラチン / 免疫染色 / 前駆細胞 / Corneal epithelium / Stem Cells / Hypoxia / Cell Culture / Cytokeratin / Regenerative Medicine / Immunohistochemistry / Progenitor Cells / フックス角膜変性症 / iPS細胞 / フックス角膜内皮変性症 / 疾患iPS / 疾患iPS細胞 / ドラッグ・リポジショニング / ドラッグリポジショニング / 多能性幹細胞 / 間葉系幹細胞 … More Except Principal Investigator ドライアイ / 線維化 / 慢性移植片対宿主病 / 眼科学 / 三叉神経 / 眼病理学 / 移植片対宿主病 / 線維芽細胞 / 再生医学 / 免疫応答 / 造血幹細胞移植 / 間葉系幹細胞 / 眼免疫 / 涙腺 / 造血幹細胞 / 角膜 / 骨髄幹細胞 / 眼発生 / 角膜上皮細胞 / ケラチン12 / 角膜上皮 / ケラチン１２ / 幹細胞 / T細胞 / 炎症 / 上皮幹細胞 / メラノサイト / 培養上皮シート / 角膜輪部上皮 / 幹細胞ニッチ / 角膜上皮幹細胞 / 眼GVHD / 細胞老化 / 免疫 / 老化細胞 / マクロファージ / 角膜神経再生 / Semaphorin3A / 神経再生 / Semaphorin / 眼細胞生物学 Less

間葉系幹細胞（MSC）の生体内作用における新たな細胞極性化の証明Principal Investigator
- Principal Investigator
  
  榛村重人
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Keio University
Development of a novel drug to treat corneal dystrophy by drug repositioningPrincipal Investigator
- Principal Investigator
  
  SHIMMURA Shigeto
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Keio University
Elucidating the pathogenesis of Fuchs corneal dystrophy using disease iPSCsPrincipal Investigator
- Principal Investigator
  
  Shimmura Shigeto
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Keio University
Effect of a Sema3A inhibitor treatment in a murine dry eye model
- Principal Investigator
  
  Satoru Yoshida
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Fujita Health University
  National Institutes of Biomedical Innovation, Health and Nutrition
  Keio University
A significant role of senescent cells and donor mesenchymal stem cells in ocular chronic graft-versus-host disease and development of new therapy
- Principal Investigator
  
  Ogawa Yoko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Keio University
Melanocyte stem cells as a niche for corneal epithelial stem cells
- Principal Investigator
  
  MIYASHITA Hideyuki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Keio University
Directed induction of skin derived precursors into corneal endotheliumPrincipal Investigator
- Principal Investigator
  
  SHIMMURA Shigeto
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Keio University
Focus on mechanism of chronic ocular graft-vessus-host disease caused by donor-derived mesenchymal stem cells toward development of new treatment.
- Principal Investigator
  
  OGAWA Yoko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Keio University
Analyssis of the fate determination mechanism to corneal epithelial cells using fluorescent reporter
- Principal Investigator
  
  YOSHIDA Satoru
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Keio University
Regulation mechanism of corneal stem cell differentiation and proliferation by oxygen concentrationPrincipal Investigator
- Principal Investigator
  
  SHIMMURA Shigeto
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Keio University
A semaphorin 3A inhibitor accelerates cornel reinnervation following penetrating keratoplasty on mice
- Principal Investigator
  
  OMOTO Masahiro
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Keio University
Analysis of the onset of ocular chronic graft versus host disease caused by donor-derived fibroblasts and the development of the new therapeutic intervention
- Principal Investigator
  
  OGAWA Yoko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Keio University
The mechanism of peripheral nerve regeneration following corneal transplantation on mice
- Principal Investigator
  
  OMOTO Masahiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Keio University
Hypoxic culture in the isolation of corneal stem cellsPrincipal Investigator
- Principal Investigator
  
  SHIMMURA Shigeto
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Tokyo Dental Collage
角膜上皮細胞におけるラクトフェリンレセプターと酸化ストレスPrincipal Investigator
- Principal Investigator
  
  榛村重人
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Ophthalmology
- Research Institution
  Tokyo Dental College
角膜上皮細胞におけるヘムオキシゲナーゼを介した酸化ストレス防御機構の解明Principal Investigator
- Principal Investigator
  
  榛村重人
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Ophthalmology
- Research Institution
  Keio University

[Book] iPS 細胞からの角膜上皮誘導. 臨床眼科増刊オキュラーサーフェス診療アップデート2012
- Author(s)
  羽藤晋, 吉田悟, 榛村重人
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-22591966
[Book] オキュラーサーフェス診療アップデート2012
- Author(s)
  羽藤晋　吉田悟　榛村重人
- Total Pages
  4
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-24592644
[Journal Article] The Semaphorin 3A inhibitor SM-345431 preserves corneal nerve and epithelial integrity in a murine dry eye model2017
- Author(s)
  Yamazaki Risa、Yamazoe Katsuya、Yoshida Satoru、Hatou Shin、Inagaki Emi、Okano Hideyuki、Tsubota Kazuo、Shimmura Shigeto
- Journal Title
  
  Scientific Reports
  
  Volume: 7
- DOI
  10.1038/s41598-017-15682-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11299
[Journal Article] MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model.2016
- Author(s)
  Ogawa Y, Morikawa S, Okano H, Mabuchi Y, Suzuki S, Yaguchi T, Sato Y, Mukai S, Yaguchi S, Inaba T, Okamoto S, Kawakami Y, Tsubota K, Matsuzaki Y, Shimmura S.
- Journal Title
  
  elife
  
  Volume: 5
- DOI
  10.7554/elife.09394
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462668, KAKENHI-PROJECT-25463226, KAKENHI-PROJECT-15K06853
[Journal Article] Possible involvement of epithelial-mesenchymal transition in fibrosis associated with IgG4-related Mikulicz's disease.2015
- Author(s)
  Fukui M, Ogawa Y, Shimmura S, Hatou S, Ichihashi Y, Yaguchi S, Hirayama M, Kawakita T, Tsubota K.
- Journal Title
  
  Moden Rheumatology
  
  Volume: 25 Pages: 737-743
- DOI
  10.3109/14397595.2014.1002968
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462668, KAKENHI-PROJECT-25860415
[Journal Article] Tissue renin angiotensin system in lacrimal gland fibrosis in a murine model of chronic graft-versus-host Disease.2015
- Author(s)
  Yaguchi S, Ogawa Y, Kawakita T, Shimmura S, Tsubota K.
- Journal Title
  
  Cornea
  
  Volume: 34
- DOI
  10.1097/ico.0000000000000586
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462668
[Journal Article] Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease2013
- Author(s)
  Kawai M, Ogawa Y, Shimmura S, Ohta S, Suzuki T, Kawamura N, Kuwana M, Kawakami Y, Tsubota K.
- Journal Title
  
  Sci Rep
  
  Volume: 3 Pages: 2455-2455
- DOI
  10.1038/srep02455
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592590
[Journal Article] Long-term maintenance of limbal epithelial progenitor cells using rho kinase inhibitor and keratinocyte growth factor2013
- Author(s)
  Miyashita H, Yokoo S, Yoshida S, Kawakita T, Yamagami S, Tsubota K, Shimmura S.
- Journal Title
  
  Stem Cells Transl Med.
  
  Volume: 2 Pages: 758-65
- DOI
  10.5966/sctm.2012-0156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592618, KAKENHI-PROJECT-24791839, KAKENHI-PROJECT-25861650
[Journal Article] Angiotensin II type 1 receptor antagonist attenuates lacrimal gland, lung, and liver fibrosis in a murine model of chronic graft-versus-host disease2013
- Author(s)
  Yaguchi S, Ogawa Y, Shimmura S, Kawakita T, Hatou S, Satofuka S, Nakamura S, Imada T, Miyashita H, Yoshida S, Yaguchi T, Ozawa Y, Mori T, Okamoto S, Kawakami Y, Ishida S, Tsubota K.
- Journal Title
  
  PLoS ONE.
  
  Volume: 8
- DOI
  10.1371/journal.pone.0064724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592590, KAKENHI-PROJECT-24592647, KAKENHI-PROJECT-25830122
[Journal Article] Mucosal Microvilli in Dry Eye Patients with Chronic Graft-Versus-Host Disease.2012
- Author(s)
  Tatematsu Y, Ogawa Y, Shimmura S, Dogru M, Yaguchi S, Nagai T, Yamazaki K, Kameyama K, Okamoto S, Kawakami Y, Tsubota K
- Journal Title
  
  Bone Marrow Transplant.
  
  Volume: 47(3) Pages: 416-425
- DOI
  10.1038/bmt.2011.89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592590
[Journal Article] Presence and physiologic function of the Renin-Angiotensin System in mouse lacrimal gland.2012
- Author(s)
  Yaguchi S, Ogawa Y, Shimmura S, Hatou S, Nakamura S, Inaba T, Imada T, Ozawa Y, Kawakami Y, Ishida S, Tsubota K.
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 53 Pages: 5416-25
- DOI
  10.1167/iovs.12-9891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592588, KAKENHI-PROJECT-23592590, KAKENHI-PROJECT-24592647
[Journal Article] Functional corneal endothelium derived from corneal stroma stem cells of neural crest origin by retinoic acid and Wnt/β-catenin signaling.2012
- Author(s)
  Hatou S, Yoshida S, Higa K, Miyashita H, Inagaki E, Okano H, Tsubota K, Shimmura S.
- Journal Title
  
  Stem Cells Dev.
  
  Volume: 22(5) Pages: 828-839
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592644
[Journal Article] Accumulation of secretory vesicles in the lacrimal gland epithelia is related to non-Sjögren's type dry eye in visual display terminal users.2012
- Author(s)
  Kamoi M, Ogawa Y, Nakamura S, Dogru M, Nagai T, Obata H, Ito M, Kaido M, Kawakita T, Okada Y, Kawakami Y, Shimmura S, Tsubota K.
- Journal Title
  
  PLoS ONE
  
  Volume: 7巻 Pages: 1-8
- DOI
  10.1371/journal.pone.0043688
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591957, KAKENHI-PROJECT-23592590, KAKENHI-PROJECT-24791877
[Journal Article] Oxidative stress induced inflammation initiates functional decline of tear production.2012
- Author(s)
  Uchino Y, Kawakita T, Miyazawa M, Ishii T, Onouchi H, Yasuda K, Ogawa Y, Shimmura S, Ishii N, Tsubota K.
- Journal Title
  
  PLoS One
  
  Volume: 7
- DOI
  10.1371/journal.pone.0045805
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510064, KAKENHI-PROJECT-22689012, KAKENHI-PROJECT-23592590, KAKENHI-PROJECT-23650602
[Journal Article] Fate of corneal epithelial cells separated from limbus in vivo2011
- Author(s)
  Kawakita T, Higa K, Shimmura S, Tomita M, Tsubota K, Shimazaki J
- Journal Title
  
  Investigative Ophthalmology & Visual Science
  
  Volume: 52 Pages: 8132-8137
- DOI
  10.1167/iovs.11-7984
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592264
[Journal Article] Greneration of stratified squamous epithelial progenitor cells from mouse induced pluripotent stem cells2011
- Author(s)
  Yoshida S, Yasuda M, Miyashita H, Ogawa Y, Yoshida T, Matsuzaki Y, Tsubota K, Okano H, Shimmura S
- Journal Title
  
  PLoS ONE
  
  Volume: 6(12) Pages: 1-1
- DOI
  10.1371/journal.pone.0028856
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390062, KAKENHI-PROJECT-22591966, KAKENHI-PROJECT-23592590, KAKENHI-PROJECT-23592616
[Journal Article] Clusterin promotes corneal epithelial cell growth through upregulation of hepatocyte growth factor by mesenchymal cells in vitro. Invest. Ophthalmol2011
- Author(s)
  Okada N, Kawakita T, Mishima K, Saito I, Miyashita H, Yoshida S, Shimmura S, Tsubota K
- Journal Title
  
  Vis. Sci
  
  Volume: 52(6) Pages: 2905-10
- DOI
  10.1167/iovs.10-6348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592264, KAKENHI-PROJECT-23390421
[Journal Article] Four cases of corneal perforation in patients with chronic graft-versus-host disease2011
- Author(s)
  Inagaki E, Ogawa Y, Matsumoto Y, Kawakita T, Shimmura S, Tsubota K
- Journal Title
  
  Mol Vis
  
  Volume: 17 Pages: 598-606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592058
[Journal Article] Four cases of corneal perforation in patients with chronic graft-versus-host disease.2011
- Author(s)
  Inagaki E, Ogawa Y, Matsumoto Y, Kawakita T, Shimmura S, Tsubota K.
- Journal Title
  
  Mol.Vis.(Corresponding author) 17
  
  Pages: 598-606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592058
[Journal Article] Simultaneous deep anterior lamellar keratoplasty (DALK) and limbal allograft (KLAL) in bilateral limbal stem cell deficiency.2010
- Author(s)
  Omoto M, Shimmura S, Tsubota K, et al.
- Journal Title
  
  Jpn J Ophthalmol. in press.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791712
[Journal Article] Immune processes and pathogenic fibrosis in ocular chronic graft versus host disease and clinical manifestations after allogeneic hematopoietic stem cell transplantation.2010
- Author(s)
  Ogawa Y, Shimmura S, Dogru M, Tsubota K.
- Journal Title
  
  Cornea
  
  Volume: 29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592058
[Journal Article] Calorie restriction : A new therapeutic intervention for age-related dry eye disease in rats.2010
- Author(s)
  Kawashima M, Kawakita T, Okada N, Ogawa Y, Dogru M, Nakamura S, Nakashima H, Shimmura S, Shinmura K, Tsubota K.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 397 Pages: 724-728
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592058
[Journal Article] Immune processes and pathogenic fibrosis in ocular chronic graft versus host disease and clinical manifestations after allogeneic hematopoietic stem cell transplantation.2010
- Author(s)
  Ogawa Y, Shimmura S, Dogru M, Tsubota K.
- Journal Title
  
  Ocular graft versus host disease. Cornea. 29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592058
[Journal Article] N-cadherin in the maintenance of human corneal limbal epithelial progenitor cells in vitro2009
- Author(s)
  Higa, K.Shimmura, S.(corresponding)Miyashita, H.Kato, N.Ogawa, Y.Kawakita, T.Shimazaki, J.Tsubota, K.
- Journal Title
  
  Invest Ophthalmol Vis Sci 50
  
  Pages: 4640-4645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592264
[Journal Article] Epithelial mesenchymal transition in human ocular chronic graft-versus-host disease.2009
- Author(s)
  Ogawa Y, Shimmura S, Kawakita T, Yoshida S, Kawakami Y, Tsubota K.
- Journal Title
  
  Am.J.Pathol. 175
  
  Pages: 2372-2381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592058
[Journal Article] Epithelial mesenchymal transition in human ocular chronic graft-versus-host disease2009
- Author(s)
  Ogawa, Y.Shimmura, S.(corresponding)Kawakita, T.Yoshida, S.Kawakami, Y.Tsubota, K.
- Journal Title
  
  Am J Pathol 175
  
  Pages: 2372-2381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592264
[Journal Article] The use of human mesenchymal stem cell-derived feeder cells for the cultivation of transplantable epithelial sheets2009
- Author(s)
  Omoto, M.Miyashita, H.Shimmura, S.(corresponding)Higa, K.Kawakita, T.Yoshida, S.McGrogan, M.Shimazaki, J.Tsubota, K.
- Journal Title
  
  Invest Ophthalmol Vis Sci 50
  
  Pages: 2109-2115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592264
[Journal Article] Epithelial mesenchymal transition in human ocular chronic graft-versus-host disease2009
- Author(s)
  Ogawa Y, Shimmura S, Kawakita T, Yoshida S, Kawakami Y, Tsubota K.
- Journal Title
  
  Am J Pathol 175
  
  Pages: 2372-2381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592058
[Journal Article] Long-term culture and growth kinetics of murine corneal epithelial cells expanded from single corneas2009
- Author(s)
  Ma, X.Shimmura, S.(corresponding)Miyashita, H.Yoshida, S.Kubota, M.Kawakita, T.Tsubota, K.
- Journal Title
  
  Invest Ophthalmol Vis Sci 50
  
  Pages: 2716-2721
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592264
[Journal Article] Mini-review.Inflammation and pathogenic fibrosis in human ocular chronic graft versus host disease.2008
- Author(s)
  Ogawa Y, Shimmura S, Kuwana M, Yamazaki K, Kawakami Y, Tsubota K.
- Journal Title
  
  Inflammation and regeneration. 28
  
  Pages: 533-540
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592058
[Journal Article] The use of human mesenchymal stem cell-derived feeder cells for the cultivation of transplantable epithelial sheets.2008
- Author(s)
  Omoto M, Miyashita H, Shimmura S, Tsubota K, et al.
- Journal Title
  
  Invest Ophthalmol Vis Sci. 50(5)
  
  Pages: 2109-2115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791712
[Journal Article] Mini-review. Inflammation and pathogenic fibrosis in human ocular chronic graft versus host disease.2008
- Author(s)
  Ogawa Y. Shimmura S, et al.
- Journal Title
  
  Inflammation and regeneration 28
  
  Pages: 533-540
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592058
[Journal Article] Proliferation and differentiation of transplantable epithelial sheets engineered with or without an amniotic membrane carrier2007
- Author(s)
  Higa K, Shimmura S, et al. (corresponding author)
- Journal Title
  
  Invest Ophthalmol Vis Sci 48
  
  Pages: 597-604
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390471
[Journal Article] Hypoxia Enhances the Expansion of Human Limbal Epithelial Progenitor Cells in Vitro.2007
- Author(s)
  Miyashita H, Higa K, Kato N, Shimmura S.
- Journal Title
  
  Invest Ophthalmol Vis Sci (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390471
[Journal Article] {beta}-Catenin Activation and Epithelial-Mesenchymal Transition in the Pathogenesis of Pterygium.2007
- Author(s)
  Kato N, Shimmura S, Kawakita T, et al.
- Journal Title
  
  Invest Ophthalmol Vis Sci (Corresponding author) 48
  
  Pages: 1511-1517
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390471
[Journal Article] Beta-catenin activation and epithelial-mesenchymal transition in the pathogenesis of pterygium2007
- Author(s)
  Kato N, Shimmura S, et al. (corresponding author)
- Journal Title
  
  Invest Ophthalmol Vis Sci 48(In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390471
[Journal Article] Proliferation and Differentiation of Transplantable Rabbit Epithelial Sheets Engineered with or without an Amniotic Membrane Carrier.2007
- Author(s)
  Higa K, Shimmura S, Kato N, et al.
- Journal Title
  
  Invest Ophthalmol Vis Sci (Corresponding author) 48
  
  Pages: 597-604
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390471
[Journal Article] Proteomic analysis of soluble factors secreted by limbal fibroblasts2006
- Author(s)
  Shimmura S, Miyashita H, et al. (corresponding author)
- Journal Title
  
  Mol Vis 12
  
  Pages: 478-484
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390471
[Journal Article] Collagen immobilized poly (vinyl alcohol) hydrogel as a artificial cornea scaffold2006
- Author(s)
  Miyashita H, Shimmura S, et al.
- Journal Title
  
  J Biomed Mater Res B Appl Biomater 76B・1
  
  Pages: 56-63
- Data Source
  KAKENHI-PROJECT-17390471
[Journal Article] Cytokeratin 15 can be used to identify the limbal phenotype in normal and diseased ocular surface2006
- Author(s)
  Yoshida S, Shimmura S, et al. (corresponding author)
- Journal Title
  
  Invest Ophthalmol Vis Sci 47
  
  Pages: 4780-4786
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390471
[Journal Article] Cytokeratin 15 can be used to identify the limbal phenotype in normal and diseased ocular surfaces.2006
- Author(s)
  Yoshida S, Shimmura S, Kawakita T, et al.
- Journal Title
  
  Invest Ophthalmol Vis Sci (Corresponding author) 47
  
  Pages: 4780-4786
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390471
[Journal Article] Proteomic analysis of soluble factors secreted by limbal fibroblasts.2006
- Author(s)
  Shimmura S, Miyashita H, Higa K, Yoshida S, Shimazaki J, Tsubota K.
- Journal Title
  
  Mol Vis (Corresponding author) 12
  
  Pages: 478-484
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390471
[Journal Article] Isolation of multipotent neural crest-derived stem cells from the adult mouse cornea.2006
- Author(s)
  Yoshida S, Shimmura S, Nagoshi N, et al.
- Journal Title
  
  Stem Cells (Corresponding author) 24
  
  Pages: 2714-2722
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390471
[Journal Article] Isolation of multipotent neural crest-derived stem cells from the adult mouse cornea2006
- Author(s)
  Yoshida S, Shimmura S, et al. (corresponding author)
- Journal Title
  
  Stem Cells 24
  
  Pages: 2714-2722
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390471
[Journal Article] Transplantation of corneal endothelium with Descemet's membrane using a hyroxyethyl methacrylate polymer as a carrier2005
- Author(s)
  Shimmura S, Miyashita H, et al.
- Journal Title
  
  Br J Ophthalmol 89・2
  
  Pages: 134-137
- Data Source
  KAKENHI-PROJECT-17390471
[Journal Article] Deep lamellar keratoplasty (DLKP) using viscoadaptive viscoelastics in keratoconus patients2005
- Author(s)
  Shimmura S, Shimazaki J, et al.
- Journal Title
  
  Cornea 24・2
  
  Pages: 178-186
- Data Source
  KAKENHI-PROJECT-17390471
[Journal Article] Serum-free spheroid culture of mouse corneal keratocytes2005
- Author(s)
  Yoshida S, Shimmura S, et al.
- Journal Title
  
  Invest Ophthalmol Vis Sci 46・5
  
  Pages: 1653-1658
- Data Source
  KAKENHI-PROJECT-17390471
[Journal Article] Melanocytes in the corneal limbus interact with K19-positive basal epithelial cells.2005
- Author(s)
  Higa K, Shimmura S, et al.
- Journal Title
  
  Exp Eye Res 81・2
  
  Pages: 218-223
- Data Source
  KAKENHI-PROJECT-17390471
[Journal Article] Hyaluronic acid-CD 44 interaction mediates the adhesion of lymphocytes by amniotic membrane stroma2005
- Author(s)
  Higa K, Shimmura S, et al.
- Journal Title
  
  Cornea 24・2
  
  Pages: 206-221
- Data Source
  KAKENHI-PROJECT-17390471
[Journal Article] Hypoxia enhances the expansion of human limbal epithelial progenitor cells in vitro
- Author(s)
  Miyashita H, Shimmura S. (corresponding author)
- Journal Title
  
  Invest Ophthalmol Vis Sci In submission
- Data Source
  KAKENHI-PROJECT-17390471
[Journal Article] Hypoxia enhances the expansion of human limbal epithelial progenitor cells in vitro
- Author(s)
  Miyashita H, Shimmura S. (corresponding author)
- Journal Title
  
  Invest Ophthalmol Vis Sci (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390471
[Patent] 組織幹細胞由来フィーダー細胞2006
- Inventor(s)
  榛村重人他3名
- Industrial Property Rights Holder
  榛村重人他3名
- Industrial Property Number
  2006-030997
- Filing Date
  2006-02-08
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390471
[Presentation] セマフォリン3A阻害薬ビナキサントンによる新規ドライアイ治療の可能性2017
- Author(s)
  山崎梨沙、山添　克弥、吉田　　悟、羽藤　　晋、稲垣　絵海、岡野　栄之、坪田　一男、榛村　重人
- Organizer
  角膜カンファランス2018
- Data Source
  KAKENHI-PROJECT-16K11299
[Presentation] Fuchs角膜内皮変性症由来iPS細胞を用いた小胞体ストレスの病態関与の検討2017
- Author(s)
  山崎梨沙、房木ノエミ、羽藤晋、稲垣絵海、宮下英之、吉田悟、坪田一男、榛村重人
- Organizer
  第41回日本角膜学会総会
- Place of Presentation
  アクロス福岡（福岡県福岡市）
- Year and Date
  2017-02-16
- Data Source
  KAKENHI-PROJECT-16K11300
[Presentation] Development of a transgenic mouse with R124H human TGFBI mutation associated with Avellino corneal dystrophy2015
- Author(s)
  Yamazoe K, Yoshida S, Hatou S, Yasuda M, Inagaki E, Ogawa Y, Tsubota K, Shimmura S. .
- Organizer
  The Annual Meeting of Association for Research in Vision and Ophthalmology 2015 (ARVO2015)
- Place of Presentation
  Denver, USA
- Year and Date
  2015-05-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462668
[Presentation] Functional analysis of tissue engineered corneal endothelium from human skin derived precursors.2015
- Author(s)
  Inagaki E, Hatou S, Higa K, Yoshida S, Miyashita H, Okano H, Tsubota K, Shimmura S.
- Organizer
  ARVO(視覚と眼科学研究協会会議)
- Place of Presentation
  Denver,USA
- Year and Date
  2015-05-05
- Data Source
  KAKENHI-PROJECT-24592644
[Presentation] Development of autoimmune type lacrimal gland GVHD in adoptively transferred mice with recipient derived T cells.2015
- Author(s)
  Ogawa Y, Shimmura S, Tsubota K.
- Organizer
  The Annual Meeting of Association for Research in Vision and Ophthalmology 2015 (ARVO2015)
- Place of Presentation
  Denver, USA
- Year and Date
  2015-05-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462668
[Presentation] Adoptive transferによる涙腺慢性GVHD発症機序の解明.2015
- Author(s)
  小川葉子, 榛村重人, 坪田一男.
- Organizer
  第119回日本眼科学会総会
- Place of Presentation
  ロイトン札幌 (北海道札幌市中央区)
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-26462668
[Presentation] 角膜内皮再生にむけた皮膚由来幹細胞から角膜内皮細胞への分化誘導2014
- Author(s)
  稲垣絵海, 羽藤晋, 比嘉一成, 吉田悟,宮下英之, 川北哲也, 岡野英之, 坪田一男,榛村重人
- Organizer
  日本再生医療学会.
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24592644
[Presentation] ヒト輪部上皮シート長期培養系を用いた上皮ターンオーバー率の推定2014
- Author(s)
  宮下英之、羽藤晋、吉田悟、坪田一男、榛村重人
- Organizer
  角膜カンファランス2014
- Place of Presentation
  沖縄県宜野湾市
- Data Source
  KAKENHI-PROJECT-25861650
[Presentation] 角膜内皮再生にむけた皮膚由来幹細胞から角膜内皮細胞への分化誘導2014
- Author(s)
  稲垣絵海, 羽藤晋, 比嘉一成, 吉田悟,宮下英之, 川北哲也, 岡野英之, 坪田一男,榛村重人
- Organizer
  角膜カンファレンス
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-24592644
[Presentation] Directed Differentiation of Skin-Derived PrecursorsInto Functional Corneal Endothelium2014
- Author(s)
  Inagaki E, Hatou S, Higa K, Yoshida S, Miyashita H, Okano H, Tsubota K, Shimmura S
- Organizer
  Gordon Research Seminor, and Conference(cornea)
- Place of Presentation
  Ventura(USA)
- Data Source
  KAKENHI-PROJECT-24592644
[Presentation] Self-assembly of the limbal epithelial stem cell niche in vitro2013
- Author(s)
  Hideyuki Miyashita, Satoru Yoshida, Tetsuya Kawakita, Kazuo Tsubota, Shigeto Shimmura
- Organizer
  ARVO2013
- Place of Presentation
  米国ワシントン州シアトル市
- Data Source
  KAKENHI-PROJECT-25861650
[Presentation] Mismatched mesenchymal stem cells as an initial trigger of ocular chronic graft-versus- host disease following allogeneic bone marrow transplantation.2013
- Author(s)
  Ogawa Y, Shimmura S, Morikawa S, Okano H, Matsuzaki Y, Tsubota K.
- Organizer
  The 3rd International Conference on Clinical & Experimental Ophthalmology
- Place of Presentation
  Chicago/Northbrook, USA
- Invited
- Data Source
  KAKENHI-PROJECT-23592590
[Presentation] Analysis of fibrosis in IgG4-related Mikulicz's disease.2013
- Author(s)
  Fukui M, Ogawa Y, Shimmura S, Hatou S, Ichihashi Y, Yaguchi S, Hirayama M, Kawakita T, Tsubota K.
- Organizer
  The 7th International Conference on the Tear Film & Ocular Surface: Basic Science and Clinical Relevance; 18-21 Sep 2013
- Place of Presentation
  Taormina, Sicily, Italy.
- Data Source
  KAKENHI-PROJECT-23592590
[Presentation] The regeneration potential of mouse lacrimal gland following duct ligation procedure2013
- Author(s)
  Liu Y, Kawakita T, Sugiyama M, Hirayama M, Kawashima M, Ogawa Y, Ito M, Shimmura S, Tsubota K.
- Organizer
  The Association for Research in Vision and Ophthalmology (ARVO) 2013, 5-9 May 2013
- Place of Presentation
  Seattle, USA
- Data Source
  KAKENHI-PROJECT-23592590
[Presentation] Donor mesenchymal stem cells expressing MHC class II molecule trigger immune responses in an animal model of lacrimal gland chronic graft-versus-host disease2013
- Author(s)
  Ogawa Y, Shimmura S, Yaguchi S, Inaba T, Tsubota K
- Organizer
  The Association for Research in Vision and Ophthalmology (ARVO) Florida
- Place of Presentation
  Florida, USA
- Data Source
  KAKENHI-PROJECT-23592590
[Presentation] Donor mesenchymal stem cells induce immune response in lacrimal gland chronic graft versus host disease in an animal model.2013
- Author(s)
  Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Sato Y, Suzuki S, Yaguchi T, Inaba, T, Yaguchi S, Okamoto S, Kawakami Y, Okano H, Maztsuzaki Y, Tsubota K.
- Organizer
  The 12th International Symposium on Sjogren's Syndrome
- Place of Presentation
  Kyoto, JAPAN
- Data Source
  KAKENHI-PROJECT-23592590
[Presentation] Mismatched mesenchymal stem cells as an initial trigger of ocular chronic graft-versus- host disease following allogeneic bone marrow transplantation2013
- Author(s)
  Ogawa Y, Shimmura S, Morikawa S, Okano H, Matsuzaki Y, Tsubota K
- Organizer
  The 3rd International Conference on Clinical & Experimental Ophthalmology Hilton Chicago/Northbrook
- Place of Presentation
  USA
- Year and Date
  2013-04-14
- Data Source
  KAKENHI-PROJECT-23592590
[Presentation] Donor mesenchymal stem cells induce immune response in lacrimal gland chronic graft versus host disease in an animal model2013
- Author(s)
  Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Sato Y, Suzuki S, Yaguchi T, Inaba, T, Yaguchi S, Okamoto S, Kawakami Y, Okano H, Maztsuzaki Y, Tsubota K
- Organizer
  The 12th International Symposium on Sjögren's Syndrome
- Place of Presentation
  Kyoto , Japan
- Data Source
  KAKENHI-PROJECT-23592590
[Presentation] Donor mesenchymal stem cells expressing MHC class II molecule trigger immune responses in an animal model of lacrimal gland chronic graft-versus-host disease.2013
- Author(s)
  Ogawa Y, Shimmura S, Yaguchi S, Inaba T, Tsubota K.
- Organizer
  The Association for Research in Vision and Ophthalmology (ARVO) 2013, 5-9 May 2013
- Place of Presentation
  Seattle, USA
- Data Source
  KAKENHI-PROJECT-23592590
[Presentation] Interaction between donor mesenchymal stem cells and recipient-derived T cells in the pathogenesis of ocular chronic graft versus host disease2012
- Author(s)
  Ogawa Y, Shimmura S, Morikawa S, Yaguchi T, Yaguchi S, Inaba T, Kawakami Y, Okano H, Matsuzaki Y, Tsubota K. .
- Organizer
  The association for research in vision and ophthalmology 2012 (ARVO 2012) Annual Meeting,
- Place of Presentation
  Fort Lauderdale, Florida, USA
- Data Source
  KAKENHI-PROJECT-23592590
[Presentation] Interaction between donor mesenchymal stem cells and recipient-derived T cells in the pathogenesis of ocular chronic graft versus host disease2012
- Author(s)
  Ogawa Y, Shimmura S, Morikawa S, Yaguchi T, Yaguchi S, Inaba T, Kawakami Y, Okano H, Matsuzaki Y, Tsubota K
- Organizer
  The association for research in vision and ophthalmology 2012 (ARVO 2012) Annual Meeting
- Place of Presentation
  Fort Lauderdale, Florida, USA
- Data Source
  KAKENHI-PROJECT-23592590
[Presentation] A role of recipient-derived T cells in ocular chronic graft-versus-host disease2012
- Author(s)
  Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Yaguchi Y, Inaba T, Kawakami Y, Okano H, Matsuzaki Y, Tsubota K
- Organizer
  1st Conference on the Tear Film and Ocular Surface in Asia
- Place of Presentation
  Kanagawa, Japan
- Data Source
  KAKENHI-PROJECT-23592590
[Presentation] Differentiation Of Induced Pluripotent Stem Cell-Derived Neural Crest Cells Into Corneal Keratocytes In Vivo International Society for Stem Cell2012
- Author(s)
  Yoshida S, Miyashita H, Ohta S, Yasuda M, Inagaki E, Tsubota K, Okano H, Shimmura S.
- Organizer
  10th Annual Meeting, Yokohama
- Place of Presentation
  Japan
- Data Source
  KAKENHI-PROJECT-22591966
[Presentation] FUNCTIONAL TISSUE ENGINEERED CORNEAL ENDOTHELIUM DERIVED FROM MOUSE CORNEAL STROMA STEM SELLS.2012
- Author(s)
  Shin Hatou, Satoru Yoshida, Kazunari Higa, Hideyuki Miyashita, Kazuo Tsubota, Shigeto Shimmura.
- Organizer
  International Society for Stem Cell Research 10th annual meeting
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24592644
[Presentation] A role of recipient-derived T cells in ocular chronic graft-versus-host disease.2012
- Author(s)
  Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Yaguchi Y, Inaba T, Kawakami Y, Okano H, Matsuzaki Y, Tsubota K.
- Organizer
  1st Conference on the Tear Film and Ocular Surface in Asia,
- Place of Presentation
  Kanagawa, Japan
- Data Source
  KAKENHI-PROJECT-23592590
[Presentation] FUNCTIONAL TISSUE ENGINEERED CORNEAL ENDOTHELIUM DERIVED FROM MOUSE CORNEAL STROMA STEM SELLS.2012
- Author(s)
  Shin Hatou, Satoru Yoshida, Kazunari Higa, Hideyuki Miyashita, Kazuo Tsubota, Shigeto Shimmura.
- Organizer
  XX Biennial Meeting of the International Society for Eye Research
- Place of Presentation
  Maritim Hotel Berlin
- Data Source
  KAKENHI-PROJECT-24592644
[Presentation] Minor antigen-mismatched MSC react with residual host T cells to trigger the progression of chronic GVHD.2012
- Author(s)
  Matsuzaki Y, Ogawa Y, Morikawa S, Okano H, Tsubota K, Shimmura S.
- Organizer
  International Society of Stem Cell Research (ISSCR) 10th Annual Meeting,
- Place of Presentation
  Yokohama, Japan.
- Data Source
  KAKENHI-PROJECT-23592590
[Presentation] 自己免疫疾患様反応を示す眼慢性GVHDマウスモデルのＴ細胞と間葉系幹細胞の相互作用2012
- Author(s)
  小川葉子, 榛村重人, 森川暁, 馬渕洋, 谷口智憲, 谷口紗織, 稲葉隆明, 岡本真一郎, 河上　裕, 岡野栄之, 松崎有未, 坪田一男..
- Organizer
  第21回日本シェーグレン症候群学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23592590
[Presentation] Minor antigen-mismatched MSC react with residual host T cells to trigger the progression of chronic GVHD2012
- Author(s)
  Matsuzaki Y, Ogawa Y, Morikawa S, Okano H, Tsubota K, Shimmura S
- Organizer
  International Society of Stem Cell Research (ISSCR) 10th Annual Meeting
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-23592590
[Presentation] 慢性移植片対宿主病症例の涙腺における免疫担当細胞の局在とT細胞の活性化2011
- Author(s)
  林勇海、小川葉子、榛村重人、川北哲也、谷口紗織、岡本真一郎、河上裕、坪田一男
- Organizer
  慶應義塾大学医学部　第4学年　自主学習発表会
- Place of Presentation
  慶應義塾大学医学部　北里講堂（東京）
- Data Source
  KAKENHI-PROJECT-23592590
[Presentation] マウス角膜移植モデルにおけるSemaphorin 3A阻害薬による神経再生促進2011
- Author(s)
  大本雅弘・榛村重人・吉田悟・川北哲也・坪田一男
- Organizer
  第35回日本角膜学会総会
- Place of Presentation
  東京
- Year and Date
  2011-05-12
- Data Source
  KAKENHI-PROJECT-21791712
[Presentation] 眼慢性移植片対宿主病におけるドナー由来線維芽細胞の細胞源の検討2011
- Author(s)
  小川葉子,榛村重人,森川暁,馬渕洋,谷口智憲,鈴木禎史,河上裕,岡野英之,松崎有未,坪田一男
- Organizer
  角膜カンファランス2011
- Place of Presentation
  東京
- Year and Date
  2011-02-18
- Data Source
  KAKENHI-PROJECT-20592058
[Presentation] 眼慢性移植片対宿主病におけるドナー由来線維芽細胞の細胞源の検討2011
- Author(s)
  小川葉子、榛村重人、森川暁、馬渕洋、谷口智憲、鈴木禎史、河上裕、岡野英之、松崎有未、坪田一男
- Organizer
  角膜カンファレンス2011
- Place of Presentation
  東京
- Year and Date
  2011-02-18
- Data Source
  KAKENHI-PROJECT-20592058
[Presentation] A Significant Role of Mesehchymal Stem Cells in Immune Processes and Pathogenic Fibrosis In Ocular Chronic Graft Versus Host Disease2011
- Author(s)
  Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Yaguchi T, Inaba T, Kawakami Y, Okano H, Matsuzaki Y, Tsubota K
- Organizer
  The Association for Research in Vision and Ophthalmology (ARVO), Annual meeting
- Place of Presentation
  Florida, U.S.A.
- Year and Date
  2011-05-04
- Data Source
  KAKENHI-PROJECT-23592590
[Presentation] A Significant Role of Mesehchymal Stem Cells in Immune Processes and Pathogenic Fibrosis In Ocular Chronic Graft Versus Host Disease2011
- Author(s)
  Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Yaguchi T, Inaba T, Kawakami Y, Okano H, Matsuzaki Y, Tsubota K.
- Organizer
  The Association for Research in Vision and Ophthalmology (ARVO), Annual Meeting, 2011
- Place of Presentation
  Florida, USA.
- Data Source
  KAKENHI-PROJECT-23592590
[Presentation] Generation of stratified squamous epithelial cells from induced pluripotent stem cells2011
- Author(s)
  Yoshida S, Yasuda M, Miyashita H, Yoshida T, Okano H, Tsubota K, Shimmura S.
- Organizer
  The Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
- Place of Presentation
  Fort Lauderdale, FL, USA
- Data Source
  KAKENHI-PROJECT-22591966
[Presentation] Inhibition of hypoxia inducible factor 2 alpha in human corneal epithelial cells delays cell cycle at G2 phase even under normoxia2011
- Author(s)
  Miyashita H, Shimmura S, Kubota M, Tsubota K
- Organizer
  The Association for Research in Vision and Ophthalmology
- Place of Presentation
  Fort Lauderdale, USA
- Data Source
  KAKENHI-PROJECT-21592264
[Presentation] ヒト角膜上皮細胞における、HIF-2Aによる細胞周期制御2011
- Author(s)
  宮下英之、久保田みゆき、吉田悟、関口友美、坪田一男、榛村重人
- Organizer
  第35回角膜カンファランス
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21592264
[Presentation] Role Of Intracellular Oxidative Stress In The Mechanism Of The Dry Eye Disease2011
- Author(s)
  Uchino Y, Kawakita T, Miyazawa M, Ishii T, Onouchi H, Yasuda K, Ogawa Y, Shimmura S, Ishii N, Tsubota K.
- Organizer
  The Association for Research in Vision and Ophthalmology (ARVO), Annual Meeting, 2011
- Place of Presentation
  Florida, USA
- Data Source
  KAKENHI-PROJECT-23592590
[Presentation] Donor mesenchymal stem cells trigger chronic graft-versus-host disease following minor antigen-mismatched bone marrow transplantation2011
- Author(s)
  Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Yaguchi T, Inaba T, Yaguchi S, Kawakami Y, Okano H, Tsubota K, Matsuzaki Y
- Organizer
  第40回日本免疫学会総会
- Place of Presentation
  千葉
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-23592590
[Presentation] ドナー間葉系幹細胞と慢性移植片対宿主病の発症機構/Donor mesenchymal stem cells trigger chronic graft-versus-host disease following minor antigen-mismatched bone marrow transplantation.2011
- Author(s)
  Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Yaguchi T, Inaba T, Suzuki S, Yaguchi S, Kawakami Y, Okano H, Tsubota K, Matsuzaki Y.
- Organizer
  第40回日本免疫学会総会
- Place of Presentation
  幕張メッセ国際会議場(千葉)
- Data Source
  KAKENHI-PROJECT-23592590
[Presentation] 眼慢性移植片対宿主病の発症機構におけるドナー間葉系幹細胞の役割2011
- Author(s)
  小川葉子、榛村重人、森川　暁、馬渕　洋、谷口智憲、鈴木禎史、河上　裕、岡野英之、松崎有未、坪田一男
- Organizer
  第115回日本眼科学会総会
- Place of Presentation
  東京国際フォーラム(東京)
- Data Source
  KAKENHI-PROJECT-23592590
[Presentation] Aquaporin 1 Positive Mesenchymal Cell Imply Existence Of Cornea Limbal Niche Cells.2011
- Author(s)
  Higa K, Kato N, Yoshida S, Ogawa Y, Shimazaki J, Tsubota K, Shimmura S.
- Organizer
  The Association for Research in Vision and Ophthalmology (ARVO), Annual Meeting, 2011
- Place of Presentation
  Florida, USA
- Data Source
  KAKENHI-PROJECT-23592590
[Presentation] A semaphorin 3A inhibitor accelerates cornel reinnervation following penetrating keratoplasty on mice.2011
- Author(s)
  M.Omoto, S.Shimmura, S Yoshida, T Kawakita, K.Tsubota
- Organizer
  The Association for Research in Vision and Ophthalmology 2011 annual meeting
- Place of Presentation
  アメリカ、フォートローダーデール
- Year and Date
  2011-05-01
- Data Source
  KAKENHI-PROJECT-21791712
[Presentation] 角膜上皮前駆細胞における、HIF2Aによる細胞周期G2進行制御2011
- Author(s)
  宮下英之、久保田みゆき、吉田悟、関口友美、坪田一男、榛村重人
- Organizer
  第10回日本再生医療学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21592264
[Presentation] Inhibition of hypoxia inducible factor 2 alpha in human corneal epithelial cells delays cell cycle at G2 phase even under normoxia2011
- Author(s)
  Hideyuki Miyashita, Shigeto Shimmura, Miyuki Kubota, Kazuo Tsubota
- Organizer
  The 2012 ARVO (Association for Research in Vision and Ophthalmology) annual meeting
- Place of Presentation
  Fort Lauderdale, Florida, USA
- Year and Date
  2011-05-01
- Data Source
  KAKENHI-PROJECT-21592264
[Presentation] Semaphorin 3A阻害薬による角膜グラフトへの神経再生促進2011
- Author(s)
  大本雅弘・榛村重人・吉田悟・川北哲也・坪田一男
- Organizer
  第35回日本角膜学会総会
- Place of Presentation
  東京
- Year and Date
  2011-02-17
- Data Source
  KAKENHI-PROJECT-21791712
[Presentation] 眼移植片対宿主病(GVHD)モデルマウスにおける涙腺の免疫組織学的検討2011
- Author(s)
  谷口紗織、小川葉子、榛村重人、坪田一男
- Organizer
  第115回日本眼科学会総会
- Place of Presentation
  東京国際フォーラム(東京)
- Data Source
  KAKENHI-PROJECT-23592590
[Presentation] Bone marrow mesenchymal stem cells trigger pathogenic fibrosis in chronic graft-versus-host-disease.2010
- Author(s)
  Ogawa Y, Shimmura Y, Morikawa S, Mabuchi Y, Inaba T, Okano H, Matsuzaki Y, Tsubota K
- Organizer
  6th International Conference on the Tear Film & Ocular Surface ; Basic Sience and Clinical Relevance.
- Place of Presentation
  Florence, Italy
- Data Source
  KAKENHI-PROJECT-20592058
[Presentation] マウスiPS細胞由来の上皮細胞を用いた重層化上皮シート作成2010
- Author(s)
  吉田悟, 榛村重人, 坪田一男
- Organizer
  第34回角膜カンファランス
- Place of Presentation
  仙台
- Year and Date
  2010-02-11
- Data Source
  KAKENHI-PROJECT-21592264
[Presentation] フィーダーが無血清培地中のヒト角膜輪部上皮の細胞寿命に与える影響2010
- Author(s)
  宮下英之, 榛村重人, 坪田一男
- Organizer
  第34回角膜カンファランス
- Place of Presentation
  仙台
- Year and Date
  2010-02-11
- Data Source
  KAKENHI-PROJECT-21592264
[Presentation] Donor fibroblast chimerism in animal model of ocular chronic graft versus host disease.2010
- Author(s)
  Ogawa Y, Shimmura S, Morikawa S, Inaba T, Okano H, Matsuzaki Y, Tsubota K.
- Organizer
  The Association of Research for Vision and Ophthalmology (ARVO) 2010.
- Place of Presentation
  Fort Lauderdale, FL, USA
- Data Source
  KAKENHI-PROJECT-20592058
[Presentation] Donor fibroblast chimerism in animal model of ocular chronic graft versus host disease2010
- Author(s)
  Ogawa,Y, Shimmura S, Morikawa S, Inaba T, Okano H, Matsuzaki Y, Tsubota K.
- Organizer
  ARVO2010
- Place of Presentation
  Fort Lauderdale, FL, USA
- Year and Date
  2010-05-05
- Data Source
  KAKENHI-PROJECT-20592058
[Presentation] Bone marrow mesenchymal stem cells trigger pathogenic fibrosis in chronic graft-versus-host-disease.2010
- Author(s)
  Ogawa Y, Shimmura Y, Morikawa S, Mabuchi Y, Inaba T, Okano H, Matsuzaki Y, Tsubota K
- Organizer
  6^<th> International Conference on the Tear Film & Ocular Surface ; Basic Science and Clinical Relevance.
- Place of Presentation
  Florence, Italy
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-20592058
[Presentation] Matrix metalloproteinase(MMP9)is expressed during corneal perforation in chronic graft-versus-host disease2010
- Author(s)
  Inagaki E, Ogawa Y, Matsumoto Y, Kawakita T, Shimmura S, Tsubota K
- Organizer
  ARVO2010
- Place of Presentation
  Fort Lauderdale, FL, USA
- Year and Date
  2010-05-02
- Data Source
  KAKENHI-PROJECT-20592058
[Presentation] Measurement of telomere length in lacrimal gland tissue sections using quantitative fluorescence in situ hybridization(Q-FISH)2010
- Author(s)
  Kawashima M, Kawakita T, Maida Y, Kamoi M, Ogawa Y, Matsutomi K, Shimmura S, Tsubota K
- Organizer
  ARVO2010
- Place of Presentation
  Fort Lauderdale, FL, USA
- Year and Date
  2010-05-05
- Data Source
  KAKENHI-PROJECT-20592058
[Presentation] Differentiation of induced pluripotent stem cells into corneal epithelial cells2010
- Author(s)
  Yoshida S, Yasuda M, Miyashita H, Yoshida T, Tsubota K, Okano H, Shimmura S
- Organizer
  The 16th International Conference of the International Society of Differentiation
- Place of Presentation
  Nara, Japan
- Data Source
  KAKENHI-PROJECT-22591966
[Presentation] 眼慢性移殖片対宿主病における上皮間葉転換2010
- Author(s)
  小川葉子、榛村重人、川北哲也、吉田悟、河上裕、坪田一男
- Organizer
  第30回炎症再生医学会
- Place of Presentation
  東京
- Year and Date
  2010-08-05
- Data Source
  KAKENHI-PROJECT-20592058
[Presentation] 角膜上皮細胞内 Clusterin の細胞増殖および酸化ストレスへの役割2010
- Author(s)
  岡田直子, 榛村重人, 川北哲也, 川島素子, 美島健二, 齋藤一郎, 坪田一男
- Organizer
  第34回角膜カンファランス
- Place of Presentation
  仙台
- Year and Date
  2010-02-11
- Data Source
  KAKENHI-PROJECT-21592264
[Presentation] Bone marrow mesenchymal stem cells trigger pathogenic fibrosis in chronic graft-versus-host-disease.2010
- Author(s)
  Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Inaba T, Okano H, Matsuzaki Y, Tsubota K.
- Organizer
  Gordon Conference. 1^<st> Biology & Pathobiology of the Cornea.
- Place of Presentation
  Ventura, CA, USA.
- Data Source
  KAKENHI-PROJECT-20592058
[Presentation] 眼慢性移殖片対宿主病における上皮間葉転換2010
- Author(s)
  小川葉子、榛村重人、川北哲也、吉田悟、河上裕、坪田一男
- Organizer
  第30回日本炎症再生医学会
- Data Source
  KAKENHI-PROJECT-20592058
[Presentation] Differentiation of induced pluripotent stem cells into corneal epithelial cells.2010
- Author(s)
  Yoshida S, Shimmura S, Okano H, Tsubota K.
- Organizer
  The Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
- Place of Presentation
  Fort Lauderdale, FL, USA
- Data Source
  KAKENHI-PROJECT-22591966
[Presentation] Analysis of pathogenic fibrosis in animal model of ocular chornic graft versus host disease.2009
- Author(s)
  Ogawa Y, Shimmura S, Inaba T, Okano H, Kawakami Y, Tsubota K.
- Organizer
  The 9^<th> world congress of inflammation.
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2009-07-07
- Data Source
  KAKENHI-PROJECT-20592058
[Presentation] マウス涙腺慢性移植片対宿主病モデルにおける病的線維化の発症と進展機序の解析2009
- Author(s)
  小川葉子,榛村重人,稲葉隆明,河上裕,岡野栄之,坪田一男
- Organizer
  第113回日本眼科学会総会
- Place of Presentation
  東京
- Year and Date
  2009-04-16
- Data Source
  KAKENHI-PROJECT-20592058
[Presentation] マウス涙腺慢性移植片対宿主病モデルにおける病的線維化の発症と進展機序の解析2009
- Author(s)
  小川葉子, 榛村重人, 稲葉隆明, 河上裕, 岡野栄之, 坪田一男
- Organizer
  第113回日本眼科学会総会
- Place of Presentation
  東京
- Year and Date
  2009-04-16
- Data Source
  KAKENHI-PROJECT-21592264
[Presentation] カロリー制限による加齢性涙液分泌能低下の抑制2009
- Author(s)
  川島素子, 川北哲也, 岡田直子, 小林真也, 小川葉子, 村戸ドール, 榛村重人, 新村健, 坪田一男
- Organizer
  第33回角膜カンファランス
- Place of Presentation
  大阪
- Year and Date
  2009-02-20
- Data Source
  KAKENHI-PROJECT-20592058
[Presentation] Analysis of pathogenic fibrosis in animal model of ocular chronic graft versus host disease2009
- Author(s)
  Ogawa Y, Shimmura S, Inaba T, Okano H, Kawakami Y, Tsubota K.
- Organizer
  The 9th WCI : World Congress on Inflammation
- Place of Presentation
  Tokyo
- Year and Date
  2009-07-07
- Data Source
  KAKENHI-PROJECT-20592058
[Presentation] 角膜再生医療2009
- Author(s)
  榛村重人
- Organizer
  第25回日本DDS学会
- Place of Presentation
  東京
- Year and Date
  2009-07-03
- Data Source
  KAKENHI-PROJECT-21592264
[Presentation] 角膜輪部上皮未分化細胞の維持とN-cadherinの関係2009
- Author(s)
  比嘉一成, 榛村重人, 加藤直子, 宮下英之, 小川葉子, 川北哲也, 島崎潤, 坪田一男
- Organizer
  第33回角膜カンファランス
- Place of Presentation
  大阪
- Year and Date
  2009-02-19
- Data Source
  KAKENHI-PROJECT-20592058
[Presentation] ヒト骨髄間葉系幹細胞のフィーダー細胞としての有用性2009
- Author(s)
  大本雅弘・宮下英之・比嘉一成・坪田一男・榛村重人
- Organizer
  第8回日本再生医療学会総会
- Place of Presentation
  東京
- Year and Date
  2009-03-06
- Data Source
  KAKENHI-PROJECT-19791292
[Presentation] Mikulictz病を疑った4例の血清IgG4値、涙腺生検所見、治療経過の比較検討2009
- Author(s)
  平山雅敏, 羽藤晋, 小川葉子, 亀山香織, 海道美奈子, 石田玲子, 榛村重人, 坪田一男
- Organizer
  第33回角膜カンフアランス
- Place of Presentation
  大阪
- Year and Date
  2009-02-20
- Data Source
  KAKENHI-PROJECT-20592058
[Presentation] マウス涙腺慢性移植片対宿主病モデルにおける病的線維化の発症と進展機序の解析2009
- Author(s)
  小川葉子, 榛村重人, 稲葉隆明, 河上裕, 岡野栄之, 坪田一男
- Organizer
  第113回日本眼科学会総会, 東京
- Place of Presentation
  東京
- Year and Date
  2009-04-16
- Data Source
  KAKENHI-PROJECT-20592058
[Presentation] 抗癌剤TS-1^Rによる閉塞性マイボーム腺機能不全2009
- Author(s)
  松本幸裕, 村戸ドール, 佐藤エンリケアダン, オサマイブラヒム, 立松由佳子, 小川葉子, 榛村重人, 坪田一男
- Organizer
  第33回角膜カンファランス
- Place of Presentation
  大阪
- Year and Date
  2009-02-20
- Data Source
  KAKENHI-PROJECT-20592058
[Presentation] SOD1による角膜血管新生の抑制2009
- Author(s)
  久保田みゆき, 栗原俊英, 久保田俊介, 石田晋, 坪田一男, 榛村重人
- Organizer
  第113回日本眼科学会総会
- Place of Presentation
  東京
- Year and Date
  2009-04-16
- Data Source
  KAKENHI-PROJECT-21592264
[Presentation] マウス慢性移植片対宿主病における線維化病変の検討2009
- Author(s)
  小川葉子,榛村重人,森川暁,鈴木禎史,稲葉隆明,河上裕,岡野栄之,松崎有未,坪田一男
- Organizer
  第8回日本再生医療学会
- Place of Presentation
  東京
- Year and Date
  2009-03-06
- Data Source
  KAKENHI-PROJECT-20592058
[Presentation] 慢性移植片対宿主病の結膜上皮における上皮間葉系移行2008
- Author(s)
  小川葉子,榛村重人,川北哲也,河上裕,岡野栄之,坪田一男
- Organizer
  第32回角膜カンファランス
- Place of Presentation
  東京
- Year and Date
  2008-02-28
- Data Source
  KAKENHI-PROJECT-20592058
[Presentation] Epithelial-Mesenchymal Transition of Conjunctival Basal Epithelia in Human Chronic Graft versus Host Disease.2008
- Author(s)
  Ogawa Y, Shimmura S, Kawakita T, Okano H, Kawakami K, Tsubota K.
- Organizer
  The Association for Research in Vision and Ophthalmology (ARVO2008), Annual meeting
- Place of Presentation
  Florida, USA.
- Data Source
  KAKENHI-PROJECT-20592058
[Presentation] The Use of Human Mesenchymal Stem Cells as Feeder Cells in Cultivated Corneal Epithelial Sheets2008
- Author(s)
  M. Omoto, H. Miyashita, K. Higa, K. Tsubota, S. Shimmura
- Organizer
  The Association for Research in Vision and Ophthalmology 2008 annual meeting
- Place of Presentation
  アメリカ、フォートローダーデール
- Year and Date
  2008-05-01
- Data Source
  KAKENHI-PROJECT-19791292
[Presentation] Corneal Wound Healing Following Penetrating Keratoplasty on Mice2007
- Author(s)
  M. Omoto, S. Shimmura, S. Yoshida, H. Miyashita, K. Tsubota
- Organizer
  The Association for Research in Vision and Ophthalmology 2007 annual meeting
- Place of Presentation
  アメリカ、フォートローダーデール
- Year and Date
  2007-05-08
- Data Source
  KAKENHI-PROJECT-19791292
[Presentation] Localization of label retaining cells and rapidly proliferating cells in 6-month cultured primary human limbal epithelial cell sheets.
- Author(s)
  Miyashita H, Tsubota K, Shimmura S.
- Organizer
  2015 Asia-ARVO
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2015-02-16 – 2015-02-19
- Data Source
  KAKENHI-PROJECT-25861650
[Presentation] 培養上皮における秩序： K15陽性細胞、label retaining cellsとrapidly proliferating cells．
- Author(s)
  宮下英之，坪田一男，榛村重人
- Organizer
  第14回再生医療学会総会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2015-03-19 – 2015-03-21
- Data Source
  KAKENHI-PROJECT-25861650
[Presentation] Epithelial mesenchymal transition in human ocular chronic graft-versus-host disease.
- Author(s)
  Ogawa Y, Shimmura S, Kawakita T, Yoshida S, Kawakami Y, Tsubota K.
- Organizer
  第6回ドライアイリサーチアワード受賞講演(Am J Pathol. 2009;175(6):2372-2381.オキュラ-サーフェス専門別研究会第64回日本臨床眼科学会神戸平成22年11月12-15日)
- Data Source
  KAKENHI-PROJECT-20592058
[Presentation] 培養上皮シートにおけるLabel retaining cells．
- Author(s)
  宮下英之，坪田一男，榛村重人
- Organizer
  角膜カンファランス2015
- Place of Presentation
  高知県高知市
- Year and Date
  2015-02-11 – 2015-02-13
- Data Source
  KAKENHI-PROJECT-25861650
[Presentation] Macrophage expressing oxidative stress marker play some role in lacrimal gland of chronic graft-versus-host disease
- Author(s)
  Ogawa Y, Shimmura S, Suzuki T, Kawai M, Tsubota K.
- Organizer
  The Annual Meeting of Association for Research in Vision and Ophthalmology 2014 (ARVO2014)
- Place of Presentation
  Orlando, USA
- Year and Date
  2014-05-02 – 2014-05-06
- Data Source
  KAKENHI-PROJECT-26462668

1. TSUBOTA Kazuo (40163878)

# of Collaborated Projects: 6 results

# of Collaborated Products: 79 results
2. OKANO Hideyuki (60160694)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
3. YOSHIDA Satoru (50398781)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
4. OGAWA Yoko (30160774)

# of Collaborated Projects: 3 results

# of Collaborated Products: 70 results
5. OMOTO Masahiro (50385241)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
6. MATSUZAKI Yumi (50338183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
7. MIYASHITA Hideyuki (60424173)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
8. NIWANO Hiroko (90748518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HIGA Kazunari (60398782)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
10. YASUDA miyuki (80574912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 房木ノエミ (40278635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 羽藤晋 (70327542)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 森川暁 (00424169)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 平山雅敏 (90528473)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. YAMAZOE katsuya

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. YAMAZAKI risa

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. SHIMIZU shota

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. YAGUCHI Tomonori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. ITO Masataka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 福井正樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 吉田哲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 山上聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 横尾誠一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 馬渕洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 美島健二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 斎藤一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 小沢洋子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
28. 鴨居瑞加

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 石井直明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimmura Shigeto 榛村 重人

SHIMMURA Shigeto 榛村 重人

Shimmura Shimmura 榛村 重人

榛村 重人 シンムラ シゲト

Research Projects

Research Products

Co-Researchers

間葉系幹細胞（MSC）の生体内作用における新たな細胞極性化の証明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel drug to treat corneal dystrophy by drug repositioningPrincipal Investigator

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Review Section

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Elucidating the pathogenesis of Fuchs corneal dystrophy using disease iPSCsPrincipal Investigator

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Principal Investigator

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Directed induction of skin derived precursors into corneal endotheliumPrincipal Investigator

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Principal Investigator

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Regulation mechanism of corneal stem cell differentiation and proliferation by oxygen concentrationPrincipal Investigator

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Hypoxic culture in the isolation of corneal stem cellsPrincipal Investigator

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Shimmura Shigeto 榛村重人

SHIMMURA Shigeto 榛村重人

Shimmura Shimmura 榛村重人

榛村重人シンムラシゲト

[Book] iPS 細胞からの角膜上皮誘導. 臨床眼科増刊オキュラーサーフェス診療アップデート2012