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Tsubota Kazuo  坪田 一男

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TSUBOTA Kazuo  坪田 一男

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Researcher Number 40163878
Other IDs
External Links
Affiliation (Current) 2025: 慶應義塾大学, 医学部(信濃町), 名誉教授
Affiliation (based on the past Project Information) *help 2023: 慶應義塾大学, 医学部(信濃町), 講師(非常勤)
2021 – 2022: 慶應義塾大学, 医学部(信濃町), 名誉教授
2017 – 2020: 慶應義塾大学, 医学部(信濃町), 教授
2004 – 2016: 慶應義塾大学, 医学部, 教授
2015: 慶応義塾大学, 医学部, 教授 … More
2006: 慶応義塾大学, 医学部, 教授
2004: 慶応義塾大学, 医学部, 教授
2004: Tokyo Dental College, Cornea center, Chief of Research, 角膜センター, 教授(研究部長)
2003: Keio University, School of Medicine, Department of Ophthalmology, Professor, 医学部, 教授
2001 – 2003: 東京歯科大学, 歯学部, 教授
1998 – 2003: 東京歯科大学, 眼科学, 教授
2001: 東京歯科大学, 市川総合病院, 教授
1998 – 1999: Tokyo Dental College, Professor, 歯学部, 教授
1995 – 1997: 東京歯科大学, 眼科学, 助教授
1994 – 1997: 東京歯科大学, 歯学部, 助教授
1996: Tokyo Dental College, Department of Dentistry, assistant professor, 歯学部・眼科, 助教授
1995: 東京歯科大学, 歯学部眼科, 助教授
1994: Tokyo Dental College, Department of Ophthalmology, 市川総合病院・眼科, 助教授
1993: 東京歯科大学, 眼科, 助教授
1992: 東京歯科大学, 歯学部, 助教授 Less
Review Section/Research Field
Principal Investigator
Ophthalmology / Basic Section 56060:Ophthalmology-related / Biological Sciences / Laboratory medicine / Ophthalmology
Except Principal Investigator
Ophthalmology / Morphological basic dentistry / Surgical dentistry / Morphological basic dentistry / Ophthalmology … More / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Hygiene and public health / 病態科学系歯学(含放射線系歯学) / Biomedical engineering/Biomaterial science and engineering / Circulatory organs internal medicine / Gastroenterology Less
Keywords
Principal Investigator
ドライアイ / 涙腺 / シェーグレン症候群 / 涙液 / 酸化ストレス / 非視覚系オプシン / 脈絡膜 / 非視覚オプシン / バイオレットライト / OPN5 … More / 眼軸長 / 非視覚型オプシン / 近視 / 眼 / NAD / 眼科学 / Fuchs角膜内皮変性症 / 緑内障 / NAD代謝 / 抗加齢医学 / NMN / NAD関連代謝 / ミトコンドリア / CR / Sirtuin / ムスカリン性アセチルコリン受容体 / 機能性食品因子 / 角膜 / 加齢 / 老化 / カルシウム / IP3 / ELISA / 唾液腺 / 細胞膜固定 / C末結合タンパク質 / 膜輸送機構 / major urinary protein-4 / prolactin-inducible protein / odorant-binding protein-Ia / C末端結合タンパク質 / アクアポリン5 / ビデオサーモグラフィー / EBウイルス / 眼精疲労 / サイクロスポリンA / Tリンパ球 / CD4 / granzymeA / Perforin … More
Except Principal Investigator
Sjogren's syndrome / ドライアイ / シェ-グレン症候群 / 涙腺 / シェーグレン症候群 / Epstein-Barr virus / 唾液腺 / ウイルス再活性化 / EBウイルス / 口腔乾燥症 / PCR / 慢性移植片対宿主病 / 線維化 / 角膜 / NFS / HLA-G / 自己免疫疾患 / 再生 / ムチン / dry eye / lactoferrin / EBV reactivation / ZEBRA / 直上湿度 / HLA CLASS II ANTIGENS / CORNEAL TRANSPLANTATION / 拒絶反応 / 角膜移植 / 再生医療 / 炎症 / 造血幹細胞 / 眼免疫 / 間葉系幹細胞 / 造血幹細胞移植 / 免疫応答 / 線維芽細胞 / 移植片対宿主病 / 眼病理学 / 三叉神経 / 眼科学 / 点眼薬 / PAC1R / 角膜上皮再生・新生 / 涙液分泌 / スーパーアゴニスト / 結晶化 / 細胞の再生・新生 / PAC1 / 新生 / 細胞新生 / 細胞再生 / 角膜内皮 / 角膜上皮 / PACAP / 眼細胞生物学 / Semaphorin / 神経再生 / Semaphorin3A / 角膜神経再生 / マクロファージ / 老化細胞 / 免疫 / 細胞老化 / 眼GVHD / コホート研究 / 眼科疾患 / メタボロミクス / 加齢黄斑変性 / メタボローム / 分子疫学 / SP CELLS / HYPOFUNCTION / REGENERATIVE MEDICINE / SALIVARY GLANDS / SP細胞 / pathophysioloay / mucin / goblet cell / atopic keratoconjunctivitis / 病体生理 / アトピー性結膜炎 / 病態生理 / 杯細胞 / アトピー性角結膜炎 / sld mice / Linkage analysis / Autoimmune disease / 疾患関連遺伝子 / sldマウス / リンケージ解析 / Endocrine disruptor / Estrogen / EBウィルス / エストロジェン / 環境ホルモン / エストロゲン / Cytotoxic assay / immune response / Anti-inflammatory / corneal coniunctival epitherial cells / Amniotic membrane / IFN-γ / 細胞障害性試験 / 細胞障害性 / 免疫反応 / 角結膜上皮 / 羊膜 / animal model / immunotolerance / autoimmune disease / conditional expression / だ液腺 / ウイルス抗原 / 疾患モデルマウス / 免疫学的寛容 / 遺伝子発現調節システム / rat / exocrine glands / reproduction / Transgenic / Prolactine / Lama / トランスジェニックラット / ラット / 外分泌腺 / トランスジェニック / プロラクチン / Barrier function / Fluoro-photo-metory / Saliva turnover / Minor salivary gland / Oral mucosal epithelium / Sjoegren's syndrome / Xerostomia / 唾液粘度 / 唾液分泌 / バリア機能 / フルオロフォトメトリー / 唾液の動態 / 小唾液腺 / 口腔粘膜上皮 / apoptosis / virus reactivation / autoantigen / エプスタイン・バ-ウイルス / アポトーシス / 自己抗原 / エプスタイン・バーウイルス / Sjogren's sydrome / lacrimal gland transplantation / 涙液 / 移植 / ラクトフェリン / 涙液蛋白 / lactoferin / 涙腺移植 / salivary gland cell / cell line model / BZLF-1 / シエ-グレン症候群 / 唾液腺細胞 / 唾液線細胞 / 病態モデル / Epstein-Barrウイルス / Salivary gland / TGF-beta1 / TGF-β1 / 口唇腺 / REIECTION / HLAクラスII抗原 / DNA / HLAタイピング / transcription factor / 再活性化 / CAF / P / AK-1 / EBウイルス再活性化 / 転写因子 / temperature on the oral surface / evaporation from the oral surface / xerostomia / 表面温度 / REJECTION / HLA / HLAクラスII / PCR法 / HLAクラスIIタイピング / 皮膚 / 幹細胞 / 再生器官 / ペプチド / 毛包 / 口腔器官 / 再生医工学 / T細胞 / ストレス / シグナル伝達 / 老化 / 補体 / 遺伝子発現 / 再灌流傷害 / SIRT1 / sirtuin / ミトコンドリア / 脱アセチル化 / 電子伝達系 / 心保護 / 心筋虚血 / カロリー制限 / 再生医学 / 骨髄幹細胞 / 肝線維化 / 健康寿命 / 発がん / 脂肪性肝炎 / SOD1ノックアウトマウス / SOD K / 多方向性分化細胞 / 胆管細胞癌 / 四塩化炭素 / DEN / レスベラトロール / 高カロリー(高脂肪)食 / 酸化ストレス / Oマウス / SODK / 国際シェーグレン症候群シンポジウム / 日本シェーグレン症候群研究会 / 個人調査表 / 現状調査表 / 改訂診断基準 / 査定調査 / 診断基準 Less
  • Research Projects

    (38 results)
  • Research Products

    (340 results)
  • Co-Researchers

    (80 People)
  •  Investigating mechanisms of axial elongation control by non-visual opsinPrincipal Investigator

    • Principal Investigator
      Tsubota Kazuo
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56060:Ophthalmology-related
    • Research Institution
      Keio University
  •  Development and clinical application of peptide-based therapeutic agents for dry eye syndrome

    • Principal Investigator
      Shioda Seiji
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      湘南医療大学
      Hoshi University
  •  A novel prevention and treatment method of ocular aging by targeting sirtuins.Principal Investigator

    • Principal Investigator
      TSUBOTA Kazuo
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Ophthalmology
    • Research Institution
      Keio University
  •  Effect of a Sema3A inhibitor treatment in a murine dry eye model

    • Principal Investigator
      Satoru Yoshida
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Fujita Health University
      National Institutes of Biomedical Innovation, Health and Nutrition
      Keio University
  •  Metabolite profiles and age-related macular degeneration

    • Principal Investigator
      NISHIWAKI Yuji
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Hygiene and public health
    • Research Institution
      Toho University
  •  A significant role of senescent cells and donor mesenchymal stem cells in ocular chronic graft-versus-host disease and development of new therapy

    • Principal Investigator
      Ogawa Yoko
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Keio University
  •  Development of technologies for next-generation regenerative therapies

    • Principal Investigator
      Tsuji Takashi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Biomedical engineering/Biomaterial science and engineering
    • Research Institution
      Institute of Physical and Chemical Research
      Tokyo University of Science
  •  Elucidation of the mechanism to control tear secretion by anti-aging approachPrincipal Investigator

    • Principal Investigator
      Tsubota Kazuo
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Ophthalmology
    • Research Institution
      Keio University
  •  The energy metabolism and tear secretionPrincipal Investigator

    • Principal Investigator
      TSUBOTA Kazuo
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Ophthalmology
    • Research Institution
      Keio University
  •  Focus on mechanism of chronic ocular graft-vessus-host disease caused by donor-derived mesenchymal stem cells toward development of new treatment.

    • Principal Investigator
      OGAWA Yoko
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Keio University
  •  Molecular mechanism of dry eye diseasePrincipal Investigator

    • Principal Investigator
      TSUBOTA Kazuo
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Ophthalmology
    • Research Institution
      Keio University
  •  Evaluation of mechanisms by which caloric restriction regulates mitochondrial function

    • Principal Investigator
      SHINMURA Ken
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Keio University
  •  Molecular mechanism of gender gap in dry eye diseasePrincipal Investigator

    • Principal Investigator
      TSUBOTA Kazuo
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Ophthalmology
    • Research Institution
      Keio University
  •  A semaphorin 3A inhibitor accelerates cornel reinnervation following penetrating keratoplasty on mice

    • Principal Investigator
      OMOTO Masahiro
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Ophthalmology
    • Research Institution
      Keio University
  •  Analysis of the onset of ocular chronic graft versus host disease caused by donor-derived fibroblasts and the development of the new therapeutic intervention

    • Principal Investigator
      OGAWA Yoko
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Keio University
  •  IP3受容体およびムスカリニック受容体欠損マウスを用いた涙液分泌機構Principal Investigator

    • Principal Investigator
      坪田 一男
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Ophthalmology
    • Research Institution
      Keio University
  •  The role of anti-oxidative enzyme SOD1 on the development of hepatocellular carcinoma from steatohepatitis

    • Principal Investigator
      SAITO Hidetsugu
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University
  •  The mechanism of peripheral nerve regeneration following corneal transplantation on mice

    • Principal Investigator
      OMOTO Masahiro
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Ophthalmology
    • Research Institution
      Keio University
  •  Searching the tissue specific autoimmune disease related gene by linkage analysis and establishment of a diagnosis method

    • Principal Investigator
      SAITO Ichiro
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Tsurumi University
  •  Pathophysiology of conjunctival goblet cells

    • Principal Investigator
      DOGRU Murato
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Keio University
  •  DEVELOPMENT OF CULTURE METHODS FOR EXOCRINE GLAND STEM CELLS USING GENE-TRANSDUCED FEEDER CELLS AND THEIR APPLICATION FOR TREATMENT

    • Principal Investigator
      MISHIMA Kenji
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Tsurumi University
  •  The mechanism of exocrine gland disorder through estrogen and/or endocrine disruptors

    • Principal Investigator
      INOUE Hiroko
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Tsurumi University
  •  Expression of the fetal HLA-G molecule by ocular surface epithelium is enhanced when expanded on amniotic membranes

    • Principal Investigator
      SHIMAZAKI Jun
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      TOKYO DENTAL COLLEGE
  •  Identification of animal model for autoimmune disease using conditional expression of transgene

    • Principal Investigator
      SAITO Ichiro
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Tsurumi University
  •  涙液産生におけるアクアポリン5の生理的役割の解明Principal Investigator

    • Principal Investigator
      坪田 一男
    • Project Period (FY)
      2001 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Keio University
      Tokyo Dental College
  •  シェーグレン症候群診断基準査定調査の企画

    • Principal Investigator
      藤林 孝司
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Dokkyo Medical University
  •  Enhanced lacrimation and salivation in prolactin transgenic rats

    • Principal Investigator
      SAITO Ichiro
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      The University of Tokushima
  •  An organ-specific autoantigen for Sjogren's syndrome induced by Epstein-Barr virus activation

    • Principal Investigator
      SAITO Ichiro
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      The University of Tokushima
  •  A study on adhesion and retainment of saliva on the oral surface in the patient with xerostomia and Sjogren's syndrome

    • Principal Investigator
      KATAGIRI Shigeo
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      TOKYO DENTAL COLLEGE
  •  眼温度測定と気化熱解析による生体の水濡れ性測定機Principal Investigator

    • Principal Investigator
      坪田 一男
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Laboratory medicine
    • Research Institution
      Tokyo Dental College
  •  Immunohistological analysis of TGF-beta1 expression in salivary glands

    • Principal Investigator
      KATAGIRI Shigeo
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      TOKYO DENTAL COLLEGE
  •  Establishment of in vitro model for the Epstein-Barr virus reactivation in Sjogren's syndrome

    • Principal Investigator
      SAITO Ichiro
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      The University of Tokushima
  •  Lacrimal gland transplantation for improvement of the gland function

    • Principal Investigator
      ONO Masafumi
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Tokai University
      Tokyo Dental College
  •  Detection of possible factors for the Epstein-Barr virus reactivation in Sjogren's syndrome

    • Principal Investigator
      SAITO Ichiro
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      病態科学系歯学(含放射線系歯学)
    • Research Institution
      The University of Tokushima
      Tokyo Medical and Dental University
  •  HLA-DNA ANALYSIS IN CORNEAL TRANSPLANTATION

    • Principal Investigator
      SHIMAZAKI Jun
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      TOKYO DENTAL COLLEGE
  •  Analysis of temperature on the oral surface and saliva evaporation from the oral surface in the patients with xerostomia and Sjogren's syndrome.

    • Principal Investigator
      NONOYAMA Susumu
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      TOKYO DENTAL COLLEGE
  •  HLA-DNA ANALYSIS IN CORNEAL TRANSPLANTATION

    • Principal Investigator
      SHIMAZAKI Jun
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      TOKYO DENTAL COLLEGE
  •  眼乾燥症(ドライアイ)の病因論に関する免疫学的、分子生物学的研究Principal Investigator

    • Principal Investigator
      坪田 一男
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Tokyo Dental College

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation Book Patent

  • [Book] BRAIN and NERVE Vol.73 No.112021

    • Author(s)
      坪田一男、鳥居秀成、栗原俊英
    • Total Pages
      128
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Book] BRAIN and NERVE Vol.73 No.112021

    • Author(s)
      早野元詞、坪田一男
    • Total Pages
      128
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Book] 眼科2016

    • Author(s)
      中山直彦, 小川葉子, 大高 功, 坪田一男.
    • Publisher
      金原出版株式会社
    • Data Source
      KAKENHI-PROJECT-26462668
  • [Book] IV剤型別 使い分けのコツ・注意 2.ステロイド外用剤 ②眼科. 田中廣壽. 編集 一冊で極めるステロイド診療ガイド. 第一版 第一刷2015

    • Author(s)
      小川葉子, 坪田一男
    • Total Pages
      7
    • Publisher
      文光堂
    • Data Source
      KAKENHI-PROJECT-26462668
  • [Book] II 病気・病態の応じた使い方. 8. 眼科疾患患者に投与するときの注意. 田中廣壽. 編集 一冊で極めるステロイド診療ガイド. 第一版 第一刷2015

    • Author(s)
      小川葉子, 坪田一男. 文光堂 東京114-117, 2015.
    • Total Pages
      4
    • Publisher
      文光堂
    • Data Source
      KAKENHI-PROJECT-26462668
  • [Book] アンチエイジング・バトル 最終決着2014

    • Author(s)
      坪田一男
    • Total Pages
      272
    • Publisher
      朝日新聞出版
    • Data Source
      KAKENHI-PROJECT-25293356
  • [Book] シェーグレン症候群の診断と治療マニュアル 改訂第2版 監修 住田孝之, 川上 純 編集 シェーグレン症候群学会2014

    • Author(s)
      小川葉子, 坪田一男.
    • Publisher
      診断と治療社
    • Data Source
      KAKENHI-PROJECT-26462668
  • [Book] 専門医のための眼科診療クオリファイ 19 ドライアイスペシャリストへの道2013

    • Author(s)
      谷口紗織、小川葉子、坪田一男
    • Total Pages
      421
    • Publisher
      中山書店
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Book] ごきげんな人は10年長生きできる2012

    • Author(s)
      坪田一男
    • Total Pages
      198
    • Publisher
      文藝春秋新書
    • Data Source
      KAKENHI-PROJECT-22390326
  • [Book] ごきげんな人は10年長生きできる.2012

    • Author(s)
      坪田一男
    • Total Pages
      198
    • Publisher
      文藝春秋新書
    • Data Source
      KAKENHI-PROJECT-22390326
  • [Book] 人は誰でも「元気な100歳」になれる 長寿遺伝子活性化の秘訣2011

    • Author(s)
      坪田一男
    • Total Pages
      221
    • Publisher
      小学館101新書
    • Data Source
      KAKENHI-PROJECT-22390326
  • [Book] 人は誰でも「元気な100歳」になれる長寿遺伝子活性化の秘訣2011

    • Author(s)
      坪田一男
    • Total Pages
      221
    • Publisher
      小学館101新書
    • Data Source
      KAKENHI-PROJECT-22390326
  • [Book] 細胞からキレイになる遺伝子ダイエット2010

    • Author(s)
      坪田一男
    • Total Pages
      173
    • Publisher
      マガジンハウス
    • Data Source
      KAKENHI-PROJECT-22390326
  • [Book] 理系のための研究生活ガイド-テーマの選び方から留学の手続きまで2010

    • Author(s)
      坪田一男
    • Total Pages
      272
    • Publisher
      講談社
    • Data Source
      KAKENHI-PROJECT-22659312
  • [Book] 理系のための研究生活ガイド第2版2010

    • Author(s)
      坪田一男
    • Total Pages
      270
    • Publisher
      ブルーバックス
    • Data Source
      KAKENHI-PROJECT-22659312
  • [Book] 細胞からキレイになる遺伝子ダイエット.2010

    • Author(s)
      坪田一男
    • Total Pages
      173
    • Publisher
      マガジンハウス
    • Data Source
      KAKENHI-PROJECT-22390326
  • [Book] アンチエイジング医学の基礎と臨床2008

    • Author(s)
      坪田一男, 木下茂, 斎藤一郎 齋藤英胤, 白澤卓二
    • Total Pages
      455
    • Publisher
      メジカルビュー社
    • Data Source
      KAKENHI-PROJECT-19590790
  • [Journal Article] Myopia Is Suppressed by Digested Lactoferrin or Holo-Lactoferrin Administration2023

    • Author(s)
      Liang Yifan、Ikeda Shin-ichi、Chen Junhan、Zhang Yan、Negishi Kazuno、Tsubota Kazuo、Kurihara Toshihide
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 24 Issue: 6 Pages: 5815-5815

    • DOI

      10.3390/ijms24065815

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K09834, KAKENHI-PROJECT-21H03096
  • [Journal Article] Identification of Potential Therapeutic Targets for Myopic Choroidal Neovascularization via Discovery-Driven Data Mining2023

    • Author(s)
      Chen Junhan、Ikeda Shin-ichi、Negishi Kazuno、Tsubota Kazuo、Kurihara Toshihide
    • Journal Title

      Current Eye Research

      Volume: 48 Issue: 12 Pages: 1160-1169

    • DOI

      10.1080/02713683.2023.2252201

    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Journal Article] Opsin 5 mediates violet light-induced early growth response-1 expression in the mouse retina2023

    • Author(s)
      Jeong Heonuk、Lee Deokho、Jiang Xiaoyan、Negishi Kazuno、Tsubota Kazuo、Kurihara Toshihide
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1

    • DOI

      10.1038/s41598-023-44983-x

    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Journal Article] Ginkgo biloba extracts improve choroidal circulation leading to suppression of myopia in mice2023

    • Author(s)
      Hou Jing、Mori Kiwako、Ikeda Shin-ichi、Jeong Heonuk、Torii Hidemasa、Negishi Kazuno、Kurihara Toshihide、Tsubota Kazuo
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1

    • DOI

      10.1038/s41598-023-30908-1

    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Journal Article] Suppressive effects of violet light transmission on myopia progression in a mouse model of lens-induced myopia2023

    • Author(s)
      Jeong Heonuk、Kurihara Toshihide、Jiang Xiaoyan、Kondo Shinichiro、Ueno Yusuke、Hayashi Yuki、Lee Deokho、Ikeda Shin-Ichi、Mori Kiwako、Torii Hidemasa、Negishi Kazuno、Tsubota Kazuo
    • Journal Title

      Experimental Eye Research

      Volume: 228 Pages: 109414-109414

    • DOI

      10.1016/j.exer.2023.109414

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096, KAKENHI-PROJECT-20K18357
  • [Journal Article] Topical Application of Bunazosin Hydrochloride Suppresses Myopia Progression With an Increase in Choroidal Blood Perfusion2023

    • Author(s)
      Jeong Heonuk、Lee Deokho、Jiang Xiaoyan、Negishi Kazuno、Tsubota Kazuo、Kurihara Toshihide
    • Journal Title

      Investigative Opthalmology & Visual Science

      Volume: 64 Issue: 14 Pages: 15-15

    • DOI

      10.1167/iovs.64.14.15

    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Journal Article] Lipidomic analysis revealed n‐3 polyunsaturated fatty acids suppressed choroidal thinning and myopia progression in mice2022

    • Author(s)
      Mori Kiwako、Kuroha Sayoko、Hou Jing、Jeong Heonuk、Ogawa Mamoru、Ikeda Shin‐ichi、Kang Jing X.、Negishi Kazuno、Torii Hidemasa、Arita Makoto、Kurihara Toshihide、Tsubota Kazuo
    • Journal Title

      The FASEB Journal

      Volume: 36 Issue: 6 Pages: 22312-22312

    • DOI

      10.1096/fj.202101947r

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H00495, KAKENHI-PROJECT-20K09834, KAKENHI-PROJECT-21H03096
  • [Journal Article] Short-Term Exposure to Violet Light Emitted from Eyeglass Frames in Myopic Children: A Randomized Pilot Clinical Trial2022

    • Author(s)
      Torii Hidemasa、Mori Kiwako、Okano Takashi、Kondo Shinichiro、Yang Hao-Yung、Yotsukura Erisa、Hanyuda Akiko、Ogawa Mamoru、Negishi Kazuno、Kurihara Toshihide、Tsubota Kazuo
    • Journal Title

      Journal of Clinical Medicine

      Volume: 11 Issue: 20 Pages: 6000-6000

    • DOI

      10.3390/jcm11206000

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Journal Article] 光と健康の新習慣 (New Habits of Light and Health)2022

    • Author(s)
      坪田 一男
    • Journal Title

      2022 Spring Nikkei Health

      Volume: 1 Pages: 94-97

    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Journal Article] Children in Tokyo Have a Long Sustained Axial Length from Age 3 Years: The Tokyo Myopia Study2022

    • Author(s)
      Maruyama Tomoki、Yotsukura Erisa、Torii Hidemasa、Mori Kiwako、Inokuchi Mikako、Tokumura Mitsuaki、Hazra Debabrata、Ogawa Mamoru、Hanyuda Akiko、Tsubota Kazuo、Kurihara Toshihide、Negishi Kazuno
    • Journal Title

      Journal of Clinical Medicine

      Volume: 11 Issue: 15 Pages: 4413-4413

    • DOI

      10.3390/jcm11154413

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Journal Article] Vascular endothelial growth factor from retinal pigment epithelium is essential in choriocapillaris and axial length maintenance2022

    • Author(s)
      Zhang Yan、Jeong Heonuk、Mori Kiwako、Ikeda Shin-Ichi、Shoda Chiho、Miwa Yukihiro、Nakai Ayaka、Chen Junhan、Ma Ziyan、Jiang Xiaoyan、Torii Hidemasa、Kubota Yoshiaki、Negishi Kazuno、Kurihara Toshihide、Tsubota Kazuo
    • Journal Title

      PNAS Nexus

      Volume: 1 Issue: 4 Pages: 1-13

    • DOI

      10.1093/pnasnexus/pgac166

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096, KAKENHI-PROJECT-20K18357
  • [Journal Article] Clinical outcomes of KeraVio using violet light: emitting glasses and riboflavin drops for corneal ectasia: a pilot study2021

    • Author(s)
      Kobashi Hidenaga、Torii Hidemasa、Toda Ikuko、Kondo Shinichiro、Itoi Motozumi、Tsubota Kazuo
    • Journal Title

      British Journal of Ophthalmology

      Volume: 105 Issue: 10 Pages: 1376-1382

    • DOI

      10.1136/bjophthalmol-2020-316974

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Journal Article] A multicenter clinical trial of orthokeratology in school-aged children and adolescents in Japan2021

    • Author(s)
      Goto Tomoko、Shiraishi Atsushi、Ohashi Yuichi、Negishi Kazuno、Tsubota Kazuo、Nakamura Yo、Hieda Osamu、Sotozono Chie、Kinoshita Shigeru
    • Journal Title

      Japanese Journal of Ophthalmology

      Volume: 65 Issue: 5 Pages: 624-631

    • DOI

      10.1007/s10384-021-00842-8

    • NAID

      40022680245

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Journal Article] Association between ocular axial length and anthropometrics of Asian adults2021

    • Author(s)
      Shinojima Ari、Kurihara Toshihide、Mori Kiwako、Iwai Yujiro、Hanyuda Akiko、Negishi Kazuno、Torii Hidemasa、Tsubota Kazuo
    • Journal Title

      BMC Research Notes

      Volume: 14 Issue: 1 Pages: 328-328

    • DOI

      10.1186/s13104-021-05745-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Journal Article] Effect of Violet Light-Transmitting Eyeglasses on Axial Elongation in Myopic Children: A Randomized Controlled Trial2021

    • Author(s)
      Mori Kiwako、Torii Hidemasa、Hara Yutaka、Hara Michiko、Yotsukura Erisa、Hanyuda Akiko、Negishi Kazuno、Kurihara Toshihide、Tsubota Kazuo
    • Journal Title

      Journal of Clinical Medicine

      Volume: 10 Issue: 22 Pages: 5462-5462

    • DOI

      10.3390/jcm10225462

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Journal Article] Efficacy and safety of 0.01% atropine for prevention of childhood myopia in a 2-year randomized placebo-controlled study2021

    • Author(s)
      Osamu Hieda , Takahiro Hiraoka , Takashi Fujikado,et al
    • Journal Title

      Japanese Journal of Ophthalmology

      Volume: - Issue: 3 Pages: 315-325

    • DOI

      10.1007/s10384-021-00822-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19616, KAKENHI-PROJECT-18H04116, KAKENHI-PROJECT-18K09424, KAKENHI-PROJECT-21H03096
  • [Journal Article] Photobiological Neuromodulation of Resting-State EEG and Steady-State Visual-Evoked Potentials by 40 Hz Violet Light Optical Stimulation in Healthy Individuals2021

    • Author(s)
      Noda Yoshihiro、Takano Mayuko、Hayano Motoshi、Li Xuemei、Wada Masataka、Nakajima Shinichiro、Mimura Masaru、Kondo Shinichiro、Tsubota Kazuo
    • Journal Title

      Journal of Personalized Medicine

      Volume: 11 Issue: 6 Pages: 557-557

    • DOI

      10.3390/jpm11060557

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02755, KAKENHI-PROJECT-20KK0193, KAKENHI-PROJECT-21H03096, KAKENHI-PROJECT-23K21398
  • [Journal Article] Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice2021

    • Author(s)
      Xiaoyan Jiang, Machelle T Pardue, Kiwako Mori, Shin-Ichi Ikeda, Hidemasa Torii, Shane D'Souza, Richard A Lang, Toshihide Kurihara, Kazuo Tsubota
    • Journal Title

      Proc Natl Acad Sci

      Volume: 118(22) Issue: 22

    • DOI

      10.1073/pnas.2018840118

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09834, KAKENHI-PROJECT-21H03096
  • [Journal Article] Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men2020

    • Author(s)
      Irie J, Inagaki E, Fujita M, Nakaya H, Mitsuishi M, Yamaguchi S, Yamashita K, Shigaki S, Ono T, Yukioka H, Okano H, Nabeshima YI, Imai SI, Yasui M, Tsubota K, Itoh H
    • Journal Title

      Endocr J

      Volume: 67 Issue: 2 Pages: 153-160

    • DOI

      10.1507/endocrj.EJ19-0313

    • NAID

      130007802884

    • ISSN
      0918-8959, 1348-4540
    • Language
      English
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08526, KAKENHI-PROJECT-18K15399, KAKENHI-PROJECT-17H06270, KAKENHI-PROJECT-17H04353, KAKENHI-PROJECT-20H00535
  • [Journal Article] Advances in the Diagnosis and Treatment of Dry Eye2020

    • Author(s)
      Kojima T, Dogru M, Kawashima M, Nakamura S, Tsubota K.
    • Journal Title

      Prog Retin Eye Res.

      Volume: - Pages: 1-26

    • DOI

      10.1016/j.preteyeres.2020.100842

    • Open Access
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Journal Article] Hydrogen-producing milk to prevent reduction in tear stability in persons using visual display terminals.2019

    • Author(s)
      Kawashima M, Tsuno S, Matsumoto M, Tsubota K
    • Journal Title

      Ocul Surf

      Volume: 17(4) Issue: 4 Pages: 714-721

    • DOI

      10.1016/j.jtos.2019.07.008

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Journal Article] Ketone body 3-hydroxybutyrate mimics calorie restriction via the Nrf2 activator, fumarate, in the retina.2018

    • Author(s)
      Izuta Y, Imada T, Hisamura R, Oonishi E, Nakamura S, Inagaki E, Ito M, Soga T, Tsubota K.
    • Journal Title

      Aging Cell.

      Volume: 17 Issue: 1 Pages: 1-15

    • DOI

      10.1111/acel.12699

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04353, KAKENHI-PROJECT-15K00843
  • [Journal Article] Roundtable Meeting in Honolulu  ドライアイ治療の現在と未来2018

    • Author(s)
      坪田一男
    • Journal Title

      Frontiers in Dry Eye

      Volume: 13 Pages: 37-44

    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Journal Article] Compensatory increases in tear volume and mucin levels associated with meibomian gland dysfunction caused by stearoyl-CoA desaturase-1 deficiency2018

    • Author(s)
      Inaba Takaaki、Tanaka Yasuhisa、Tamaki Shusaku、Ito Tomotaka、Ntambi James M.、Tsubota Kazuo
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 1-8

    • DOI

      10.1038/s41598-018-21542-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Journal Article] 元編集長のページ. ケトン体ダイエット2018

    • Author(s)
      坪田一男
    • Journal Title

      アンチエイジング医学-日本抗加齢医学会雑誌

      Volume: 14 Pages: 87-90

    • NAID

      40021566880

    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Journal Article] Dry Eye Specialists’ Roundtable Meeting in New Orleans  ドライアイの症状と徴候のミステリアスな関係2018

    • Author(s)
      坪田一男
    • Journal Title

      Frontiers in Dry Eye

      Volume: 13 Pages: 35-43

    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Journal Article] ドライアイシンドロームを治療する2018

    • Author(s)
      坪田一男
    • Journal Title

      Biophilia

      Volume: 7 Pages: 8-12

    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Journal Article] Restoration of Tear Secretion in a Murine Dry Eye Model by Oral Administration of Palmitoleic Acid2017

    • Author(s)
      Nakamura Shigeru、Kimura Yuki、Mori Daisuke、Imada Toshihiro、Izuta Yusuke、Shibuya Michiko、Sakaguchi Hisayo、Oonishi Erina、Okada Naoko、Matsumoto Kenji、Tsubota Kazuo
    • Journal Title

      Nutrients

      Volume: 9 Issue: 4 Pages: 364-364

    • DOI

      10.3390/nu9040364

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11500, KAKENHI-PROJECT-17H04353
  • [Journal Article] Novel Treatment of Chronic Graft-Versus-Host Disease in Mice Using the ER Stress Reducer 4-Phenylbutyric Acid.2017

    • Author(s)
      Mukai S, Ogawa Y, Urano F, Kudo-Saito C, Kawakami Y, Tsubota K.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 41939-41939

    • DOI

      10.1038/srep41939

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462668
  • [Journal Article] Neuroprotective role of retinal SIRT3 against acute photo-stress.2017

    • Author(s)
      Ban N, Ozawa Y, Osada H, Jonathan B. Lin, Toda E, Watanabe M, Yuki K, Kubota S, Rajendra S. Apte, Tsubota K.
    • Journal Title

      NPJ Aging Mech Dis.

      Volume: 3 Issue: 1

    • DOI

      10.1038/s41514-017-0017-8

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16982, KAKENHI-PROJECT-17H04353, KAKENHI-PROJECT-15K10903, KAKENHI-PROJECT-16K20329
  • [Journal Article] The Semaphorin 3A inhibitor SM-345431 preserves corneal nerve and epithelial integrity in a murine dry eye model2017

    • Author(s)
      Yamazaki Risa、Yamazoe Katsuya、Yoshida Satoru、Hatou Shin、Inagaki Emi、Okano Hideyuki、Tsubota Kazuo、Shimmura Shigeto
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1

    • DOI

      10.1038/s41598-017-15682-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K11299
  • [Journal Article] Comparison of performance of the 2016 ACR-EULAR classification criteria for primary Sjogren’s syndrome with other sets of criteria in Japanese patients.2017

    • Author(s)
      Tsuboi H., Hagiwara S., Asashima H., Takahashi H., Harota T., Noma H., Umehara H., Kawakami A., Nakamura H., Sano H., Tsubota K., Ozawa Y., Takamura E., Saito I., Inoue H., Nakamura S., Moriyama M., Takeuchi T., Tanaka Y., Hirata S., Mimori T., Matsumoto I., Sumida T.
    • Journal Title

      Ann. Rheum. Dis.

      Volume: 3 Issue: 12 Pages: 2016-210758

    • DOI

      10.1136/annrheumdis-2016-210758

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05020, KAKENHI-PROJECT-26462668, KAKENHI-PROJECT-26670869, KAKENHI-PROJECT-15K11075, KAKENHI-PROJECT-16K11463, KAKENHI-PROJECT-26293430
  • [Journal Article] Heavy Chain-Hyaluronan/Pentraxin 3 from Amniotic Membrane Suppresses Inflammation and Scarring in Murine Lacrimal Gland and Conjunctiva of Chronic Graft-versus-Host Disease.2017

    • Author(s)
      Ogawa Y, He H, Mukai S, Imada T, Nakamura S, Su CW, Mahabole M, Tseng SC, Tsubota K
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1

    • DOI

      10.1038/srep42195

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462668
  • [Journal Article] MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model.2016

    • Author(s)
      Ogawa Y, Morikawa S, Okano H, Mabuchi Y, Suzuki S, Yaguchi T, Sato Y, Mukai S, Yaguchi S, Inaba T, Okamoto S, Kawakami Y, Tsubota K, Matsuzaki Y, Shimmura S.
    • Journal Title

      eLife

      Volume: 5

    • DOI

      10.7554/elife.09394

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26462668, KAKENHI-PROJECT-25463226, KAKENHI-PROJECT-15K06853
  • [Journal Article] Possible involvement of epithelial mesenchymal transition in the fibrosis associated with IgG4-related Mikulicz’s disease.2015

    • Author(s)
      Fukui M, Ogawa Y, Shimmura S, Hatou S, Ichihashi Y, Yaguchi S, Hirayama M, Kawakita T, Tsubota K.
    • Journal Title

      Modern Rheumatology

      Volume: 25 Issue: 5 Pages: 737-743

    • DOI

      10.3109/14397595.2014.1002968

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26462668, KAKENHI-PROJECT-25860415
  • [Journal Article] Tissue renin angiotensin system in lacrimal gland fibrosis in a murine model of chronic graft-versus-host Disease.2015

    • Author(s)
      Yaguchi S, Ogawa Y, Kawakita T, Shimmura S, Tsubota K.
    • Journal Title

      Cornea

      Volume: 34 Issue: Supplement 11 Pages: S142-S152

    • DOI

      10.1097/ico.0000000000000586

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26462668
  • [Journal Article] Long-term topical rebamipide and diquafosol in two cases of immune-mediated dry eye.2015

    • Author(s)
      Yamane M, Ogawa Y, Fukui M, Kamoi M, Saijo-Ban Y, Yaguchi S, Mukai S, Kawakita T, Simmura S, Tsubota K.
    • Journal Title

      Opt Vis Sci.

      Volume: 92 Issue: 4S Pages: S25-S32

    • DOI

      10.1097/opx.0000000000000523

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26462668, KAKENHI-PROJECT-26861468
  • [Journal Article] Comparisons for grading chronic ocular graft-versus-host disease: NIH eye score, Japanese dry eye score, and DEWS 2007 score.2014

    • Author(s)
      Tatematsu Y, Ogawa Y, Abe T, Kamoi M, Uchino M, Saijyo-Ban Y, Yaguchi S, Mukai S, Mori T, Okamoto S, Tsubota K.
    • Journal Title

      Sci Rep.

      Volume: 4 Issue: 1 Pages: 6680-6680

    • DOI

      10.1038/srep06680

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26462668, KAKENHI-PROJECT-26861468
  • [Journal Article] Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye.2014

    • Author(s)
      Inaba T, Hisatsune C, Sasaki Y, Ogawa Y, Ebisui E, Ogawa N, Matsui M, Takeuchi T, Mikoshiba K, Tsubota K.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 6 Pages: e99205-e99205

    • DOI

      10.1371/journal.pone.0099205

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24500451, KAKENHI-PROJECT-25221002, KAKENHI-PROJECT-26462668
  • [Journal Article] Reconstruction of small diameter arteries using decellularized vascular scaffolds2014

    • Author(s)
      Yuki Nagaoka, Hiroshi Yamada, Tsuyoshi Kimura, Akio Kishida, Toshia Fujisato, Kazuo Takakuda
    • Journal Title

      Journal of Medical and Dental Sciences

      Volume: 61(1) Pages: 33-40

    • NAID

      110009751674

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25242041
  • [Journal Article] Primary and secondary surveys on epidemiology of Sjogren's syndrome in Japan2014

    • Author(s)
      Tsuboi, H. Asashima, H. Takai, C. Hagiwara, S. Hagiya, C. Yokosawa, M. Hirota, T. Umehara, H. Kawakami, A. Nakamura, H. Sano, H. Tsubota, K. Ogawa, Y. Takamura, E. Saito, I. Inoue, H. Nakamura, S. Moriyama, M. Takeuchi, T. Tanaka, Y. Hirata, S. Mimori, T. Yoshifuji, H. Ohta, A. Matsumoto, I. Sumida, T.
    • Journal Title

      Mod Rheumatol

      Volume: 24 Issue: 3 Pages: 464-70

    • DOI

      10.3109/14397595.2013.843765

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24592783, KAKENHI-PROJECT-26462668
  • [Journal Article] Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders.2013

    • Author(s)
      Kawashima M, Ozawa Y, Shinmura K, Inaba T, Nakamura S, Kawakita T, Watanabe M, Tsubota K.
    • Journal Title

      Exp Gerontol

      Volume: 48 Issue: 10 Pages: 1096-1100

    • DOI

      10.1016/j.exger.2013.04.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23580139, KAKENHI-PROJECT-24592647, KAKENHI-PROJECT-25293356
  • [Journal Article] Dry eye disease and inflammation (Review Article)2013

    • Author(s)
      Ogawa Y, Tsubota K
    • Journal Title

      Inflamm Regen

      Volume: 33(5) Pages: 238-48

    • URL

      https://www.jstage.jst.go.jp/article/inflammregen/33/5/33_238/_pdf

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Journal Article] Dry eye disease and inflammation.2013

    • Author(s)
      Ogawa Y, Tsubota K. Review Article. 2013 .
    • Journal Title

      Inflamm Regen.

      Volume: 33 Pages: 238-248

    • NAID

      130004482314

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Journal Article] Angiotensin II type 1 receptor antagonist attenuates lacrimal gland, lung, and liver fibrosis in a murine model of chronic graft-versus-host disease.2013

    • Author(s)
      Yaguchi S, Ogawa Y, Shimmura S, Kawakita T, Hatou S, Satofuka S, Nakamura S, Imada T, Miyashita H, Yoshida S, Yaguchi T, Ozawa Y, Mori T, Okamoto S, Kawakami Y, Ishida S, Tsubota K.
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 6 Pages: e64724-e64724

    • DOI

      10.1371/journal.pone.0064724

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592590, KAKENHI-PROJECT-24592647, KAKENHI-PROJECT-25830122
  • [Journal Article] Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ.2013

    • Author(s)
      Hirayama M, Ogawa M, Oshima M, Sekine Y, Ishida K, Yamashita K,Ikeda K, Shimmura S,Kawakita T, Tsubota K, Tsuji T
    • Journal Title

      Nature communications

      Volume: 4 Issue: 1 Pages: 2497-2497

    • DOI

      10.1038/ncomms3497

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249064, KAKENHI-PROJECT-25242041
  • [Journal Article] Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease.2013

    • Author(s)
      Kawai M, Ogawa Y, Shimmura S, Ohta S, Suzuki T, Kawamura N, Kuwana M, Kawakami Y, Tsubota K.
    • Journal Title

      Sci Rep

      Volume: 3 Issue: 1 Pages: 2455-2455

    • DOI

      10.1038/srep02455

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Journal Article] International chronic ocular graft-vs-host-disease (GVHD) consensus group: Proposed diagnostic criteria for chronic GVHD (Part I)2013

    • Author(s)
      Ogawa Y, Kim SK, Dana R, Clayton J, Jain S, Rosenblatt MI, Perez VL, Shikari H, Riemens A, Tsubota K. International chronic ocular graft-vs-host-disease (GVHD) consensus group: Proposed diagnostic criteria for chronic GVHD (Part I).
    • Journal Title

      Sci Rep

      Volume: 3 Issue: 1 Pages: 3419-3419

    • DOI

      10.1038/srep03419

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Journal Article] Validation of different sets of criteria for the diagnosis of Sjögren's syndrome in Japanese patients.2013

    • Author(s)
      Tsuboi H
    • Journal Title

      Mod Rheumatol.

      Volume: 23 Issue: 2 Pages: 219-225

    • DOI

      10.1007/s10165-012-0812-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22791990, KAKENHI-PROJECT-23390421, KAKENHI-PROJECT-23592590, KAKENHI-PROJECT-23659949, KAKENHI-PROJECT-24592783, KAKENHI-PROJECT-24592835
  • [Journal Article] Accumulation of secretory vesicles in the lacrimal gland epithelia is related to non-Sjogren' s type dry eye in visual display terminal users2012

    • Author(s)
      Kamoi M, Ogawa Y, Nakamura S, Dogru M, Nagai T, Obata H, Ito M, Kaido M, Kawakita T, Okada Y, Kawakami Y, Shimmura S, Tsubota K.
    • Journal Title

      PLoS One

      Volume: 7巻 Issue: 9 Pages: 1-8

    • DOI

      10.1371/journal.pone.0043688

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591957, KAKENHI-PROJECT-23592590, KAKENHI-PROJECT-24791877
  • [Journal Article] Oxidative stress induced inflammation initiates functional decline of tear production2012

    • Author(s)
      Uchino Y, Kawakita T, Miyazawa M, Ishii T, Onouchi H, Yasuda K, Ogawa Y, Shimmura S, Ishii N, Tsubota K.
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 10 Pages: e45805-e45805

    • DOI

      10.1371/journal.pone.0045805

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22510064, KAKENHI-PROJECT-22689012, KAKENHI-PROJECT-23592590, KAKENHI-PROJECT-23650602
  • [Journal Article] Antiaging Approach for Dry Eye Treatment2012

    • Author(s)
      Tsubota K.
    • Journal Title

      Cornea.

      Volume: Suppl 1 Issue: Supplement 1 Pages: S3-S8

    • DOI

      10.1097/ico.0b013e31826a05a8

    • Data Source
      KAKENHI-PROJECT-22390326
  • [Journal Article] Age-Related Dysfunction of the Lacrimal Gland and Oxidative Stress : Evidence from the Cu,Zn-Superoxide Dismutase-1 (Sod1) Knockout Mice.2012

    • Author(s)
      Kojima T, Wakamatsu T, Dogru M, Ogawa Y, Igarashi A, Ibrahim O, Inaba T, Shimizu T, Noda S, Obata H, Nakamura S, Wakamatsu A, Shirasawa T, Shimazaki J, Negishi K, Tsubota K
    • Journal Title

      Am J Pathol.

      Volume: 180 Issue: 5 Pages: 1879-1896

    • DOI

      10.1016/j.ajpath.2012.01.019

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390326, KAKENHI-PROJECT-23592590
  • [Journal Article] Surgical management of lacrimal punctal cauterization in chronic graft-versus-host fisease related dry eye with recurrent punctal plug extrusion..2012

    • Author(s)
      Yaguchi S, Ogawa Y, Kamoi M, Uchino M, Tatematsu Y, Ban Y, Ohba E, Okamoto S, Goto E, Tsubota K.
    • Journal Title

      Bone Marrow Transplant

      Volume: 47 Issue: 11 Pages: 1465-1469

    • DOI

      10.1038/bmt.2012.50

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Journal Article] Mucosal microvilli in dry eye patients with chronic GVHD2012

    • Author(s)
      Tatematsu Y, Ogawa Y, Shimmura S, Dogru M, Yaguchi S, Nagai T, Yamazaki K, Kameyama K, Okamoto S, Kawakami Y, Tsubota K
    • Journal Title

      Bone Marrow Transplant

      Volume: 47(3) Issue: 3 Pages: 416-425

    • DOI

      10.1038/bmt.2011.89

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Journal Article] Presence and physiological function of Renin-Angiotensin System in mouse lacrimal gland.2012

    • Author(s)
      Yaguchi S, Ogawa Y, Shimmura S, Hatou S, Nakamura S, Inaba T, Imada T, Ozawa Y, Kawakami Y, Ishida S, Tsubota K.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 53 Issue: 9 Pages: 5416-25

    • DOI

      10.1167/iovs.12-9891

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592588, KAKENHI-PROJECT-23592590, KAKENHI-PROJECT-24592647
  • [Journal Article] Comparison of stem cell sources in the severity of dry eye after allogeneic haematopoietic stem cell transplantation2012

    • Author(s)
      Uchino M, Ogawa Y, Uchino Y, Mori T, Okamoto S, Tsubota K
    • Journal Title

      Br J Ophthalmol

      Volume: 96(1) Issue: 1 Pages: 34-37

    • DOI

      10.1136/bjophthalmol-2011-300514

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Journal Article] Morphologic evaluation of meibomian glands in chronic graft-versus-host disease using in vivo laser confocal microscopy.2011

    • Author(s)
      Ban Y, Ogawa Y, Ibrahim OM, Tatematsu Y, Kamoi M, Uchino M, Yaguchi S, Dogru M, Tsubota K.(*Corresponding author)
    • Journal Title

      Mol Vis.

      Volume: 17 Pages: 2533-2543

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Journal Article] Regulatory mechanisms for the production of BAFF and IL-6 are impaired in monocytes of patients of primary Sjogren's syndrome2011

    • Author(s)
      Yoshimoto K., Tanaka M., et al
    • Journal Title

      Arthritis Research and Therapy

      Volume: 13(5) Issue: 5

    • DOI

      10.1186/ar3493

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591084, KAKENHI-PROJECT-23592590
  • [Journal Article] Effect of calorie restriction on change in lacrimal gland with age.2011

    • Author(s)
      Kawashima M, Tsubota K.
    • Journal Title

      Cornea.

      Volume: Suppl 1 Issue: Supplement 1 Pages: S29-S33

    • DOI

      10.1097/ico.0b013e318228167f

    • Data Source
      KAKENHI-PROJECT-22390326
  • [Journal Article] Prevention of cytarabine-induced kerato-conjunctivitis by eye rinse in patients receiving high-dose cytarabine and total body irradiation as a conditioning for hematopoietic stem cell transplantation2011

    • Author(s)
      Mori T, Kato J, Yamane A, Aisa Y, Kawata Y, Ichimura M, Tsuneyama C, Yashima T, Ogawa Y, Tsubota K, Shigematsu N, Shimizu T, Okamoto S
    • Journal Title

      Int J Hematol

      Volume: 94: Issue: 3 Pages: 261-265

    • DOI

      10.1007/s12185-011-0912-x

    • NAID

      10029694317

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Journal Article] Generation of stratified squamous epithelial progenitor cells from mouse induced pluripotent stem cells2011

    • Author(s)
      Yoshida S, Yasuda M, Miyashita H, Ogawa Y, Yoshida T, Matsuzaki Y, Tsubota K, Okano H, Shimmura S
    • Journal Title

      PLoS One

      Volume: 6(12) Issue: 12 Pages: 1-1

    • DOI

      10.1371/journal.pone.0028856

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390062, KAKENHI-PROJECT-22591966, KAKENHI-PROJECT-23592590, KAKENHI-PROJECT-23592616
  • [Journal Article] Four cases of corneal perforation in patients with chronic graft-versus-host disease2011

    • Author(s)
      Inagaki E, Ogawa Y, Matsumoto Y, Kawakita T, Shimmura S, Tsubota K
    • Journal Title

      Mol Vis

      Volume: 17 Pages: 598-606

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Journal Article] Donor-recipient gender difference affects severity of dry eye after hematopoietic stem cell transplantation2011

    • Author(s)
      Kamoi M, Ogawa Y, Uchino M, Tatematsu Y, Mori T, Okamoto S, Tsubota K
    • Journal Title

      Eye

      Volume: 73 Issue: 7 Pages: 860-865

    • DOI

      10.1038/eye.2011.73

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Journal Article] Effect of calorie restriction on change in lacrimal gland with age2011

    • Author(s)
      川島素子、坪田一男
    • Journal Title

      Cornea

      Volume: Sup1

    • Data Source
      KAKENHI-PROJECT-22390326
  • [Journal Article] Morphologic evaluation of meibomian glands in chronic graft-versus-host disease using in vivo laser confocal microscopy2011

    • Author(s)
      Ban Y, Ogawa Y, Ibrahim OM, Tatematsu Y, Kamoi M, Uchino M, Yaguchi S, Dogru M, Tsubota K
    • Journal Title

      Mol Vis (PubMed - indexed for MEDLINE)

      Volume: 17(2) (PMID : 22025888) Pages: 2533-2543

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Journal Article] Four cases of corneal perforation in patients with chronic graft-versus-host disease.2011

    • Author(s)
      Inagaki E, Ogawa Y, Matsumoto Y, Kawakita T, Shimmura S, Tsubota K.
    • Journal Title

      Mol.Vis.(Corresponding author) 17

      Pages: 598-606

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Journal Article] Comparison of telomere length and association with progenitor cell markers in lacrimal gland between Sjogren syndrome and non-Sjogren syndrome dry eye patients.2011

    • Author(s)
      Kawashima M, Kawakita T, Maida Y, Kamoi M, Ogawa Y, Shimmura S, Masutomi K, Tsubota K.
    • Journal Title

      Mol Vis.

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390326
  • [Journal Article] Comparison of telomere length and association with progenitor cell markers in lacrimal gland between Sjogren syndrome and non-Sjogren syndrome dry eye patients2011

    • Author(s)
      川島素子、坪田一男
    • Journal Title

      Molecular Vision

      Volume: 17 Pages: 1397-1404

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390326
  • [Journal Article] Dysfunction of corneas and lacrimal glands in smoking model rat2011

    • Author(s)
      Higuchi A, Ito K, Dogru M, Kitamura M, Kawakita T, Ogawa Y, and Tsubota K
    • Journal Title

      Free Rad Biol Med

      Volume: 51 Issue: 12 Pages: 2210-2216

    • DOI

      10.1016/j.freeradbiomed.2011.09.025

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390235, KAKENHI-PROJECT-23592590
  • [Journal Article] Comparison of telomere length and association with progenitor cell markers in lacrimal gland between Sjogren syndrome and non-Sjogren syndrome dry eye patients2011

    • Author(s)
      Kawashima M, Kawakita T, Maida Y, Kamoi M, Ogawa Y, Shimmura S, Masutomi K, Tsubota K
    • Journal Title

      Mol Vis

      Pages: 1397-1404

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659312
  • [Journal Article] Topical tranilast for treatment of the early stage of mild dry eye associated with chronic GVHD.2010

    • Author(s)
      Ogawa Y, Dogru M, Uchino M, Tatematsu Y, Kamoi M, Yamamoto Y, Ogawa J, Ishida R, Kaido M, Hara S, R, Matsumoto Y, Kawakita T, Tsubota K.
    • Journal Title

      Bone Marrow Transplant.(Corresponding author) 45

      Pages: 565-569

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Journal Article] Simultaneous deep anterior lamellar keratoplasty and limbal allograft in bilateral limbal stem cell deficiency.2010

    • Author(s)
      大本雅弘、坪田一男, ら
    • Journal Title

      Japanese Journal of Ophthalmology

      Volume: 54(6) Pages: 537-543

    • NAID

      10027666184

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791712
  • [Journal Article] Baseline profiles of ocular surface and tear dynamics after allogeneic hematopoietic stem cell transplantation in patients with or without chronic GVHD-related dry eye.2010

    • Author(s)
      Wang Y, Ogawa Y, Dogru M, Tatematsu Y, Uchino M, Kamoi M, Okada N, Okamoto S, Tsubota K.
    • Journal Title

      Bone Marrow Transplant.(Corresponding author) 45

      Pages: 1077-1083

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Journal Article] Calorie restriction: A new therapeutic intervention for age-related dry eye disease in rats.2010

    • Author(s)
      Kawashima M, Kawakita T, Okada N, Ogawa Y, Murat D, Nakamura S, Nakashima H, Shimmura S, Shinmura K, Tsubota K.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 397(4) Issue: 4 Pages: 724-8

    • DOI

      10.1016/j.bbrc.2010.06.018

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390326
  • [Journal Article] Anti-aging in ophthalmology.2010

    • Author(s)
      坪田一男
    • Journal Title

      Ophthalmic Res.

      Volume: 44 Pages: 145-145

    • NAID

      40018277559

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390326
  • [Journal Article] The era of antiaging ophthalmology comes of age : antiaging approach for dry eye treatment.2010

    • Author(s)
      Tsubota K, Kawashima M, Inaba T, Dogru M, Ogawa Y, Nakamura S, Shinmura K, Higuchi A, Kawakita T.
    • Journal Title

      Ophthalmic Res

      Volume: 44 Pages: 146-54

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Journal Article] Topical tranilast for treatment of the early stage of mild dry eye associated with chronic GVHD2010

    • Author(s)
      Ogawa Y, Dogru M, Uchino M, Tatematsu Y, Kamoi M, Yamamoto Y, Ogawa J, Ishida R, Kaido M, Hara S, R, Matsumoto Y, Kawakita T, Tsubota K.
    • Journal Title

      Bone Marrow Transplant 45

      Pages: 565-569

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Journal Article] Baseline profiles of ocular surface and tear dynamics after allogeneic hematopoietic stem cell transplantation in patients with or without chronic GVHD-related dry eye. : 2010.2010

    • Author(s)
      Wang Y, Ogawa Y, Dogru M, Tatematsu Y, Uchino M, Kamoi M, Okada N, Okamoto S, Tsubota K
    • Journal Title

      Bone Marrow Transplant

      Volume: 45 Pages: 1077-1083

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Journal Article] The era of antiaging ophthalmology comes of age : antiaging approach for dry eye treatment.2010

    • Author(s)
      坪田一男
    • Journal Title

      Ophthalmic Res.

      Volume: 44 Pages: 146-154

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390326
  • [Journal Article] The Era of Antiaging Ophthalmology Comes of Age: Antiaging Approach for Dry Eye Treatment.2010

    • Author(s)
      Tsubota K, Kawashima M, Inaba T, Dogru M, Ogawa Y, Nakamura S, Shinmura K, Higuchi A, Kawakita T
    • Journal Title

      Ophthalmic Res

      Volume: 44 Issue: 3 Pages: 146-154

    • DOI

      10.1159/000316594

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390326
  • [Journal Article] Lacrimal gland in Sjogren's syndrome2010

    • Author(s)
      Sato EA, Matsumoto Y, Dogru M, Kaido M, Wakamatsu T, Ibrahim OM, Obata H, Tsubota K
    • Journal Title

      Ophthalmology

      Volume: 117(5) Pages: 1055-1055

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659312
  • [Journal Article] Lacrimal gland in Sjogren's syndrome.2010

    • Author(s)
      佐藤エンリケアダン、坪田一男
    • Journal Title

      Ophthalmology.

      Volume: 117 Pages: 1050-1055

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659312
  • [Journal Article] Topical tranilast for treatment of the early stage of mild dry eye associated with chronic GVHD.2010

    • Author(s)
      Ogawa Y, Dogru M, Uchino M, Tatematsu Y, Kamoi M, Yamamoto Y, Ogawa J, Ishida R, Kaido M, Hara S, R, Matsumoto Y, Kawakita T, Tsubota K.
    • Journal Title

      Bone Marrow Transplant

      Volume: 45 Pages: 565-569

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Journal Article] TS-1 induces meibomian gland dysfunction.2010

    • Author(s)
      Matsumoto Y, Dogru M, Sato EA, Ibrahim OM, Tatematsu Y, Ogawa Y, Tsubota K.
    • Journal Title

      Ophthalmology

      Volume: 117

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Journal Article] Calorie restriction : A new therapeutic intervention for age-related dry eye disease in rats.2010

    • Author(s)
      Kawashima M, Kawakita T, Okada N, Ogawa Y, Dogru M, Nakamura S, Nakashima H, Shimmura S, Shinmura K, Tsubota K.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 397 Pages: 724-728

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Journal Article] Anti-aging in ophthalmology.2010

    • Author(s)
      Tsubota K.
    • Journal Title

      Ophthalmic Res

      Volume: 44(3) Issue: 3 Pages: 145-145

    • DOI

      10.1159/000316446

    • NAID

      40018277559

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390326
  • [Journal Article] Calorie restriction : A new therapeutic intervention for age-related dry eye disease in rats.2010

    • Author(s)
      川島素子、坪田一男
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 397 Pages: 724-728

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390326
  • [Journal Article] Immune processes and pathogenic fibrosis in ocular chronic graft versus host disease and clinical manifestations after allogeneic hematopoietic stem cell transplantation.2010

    • Author(s)
      Ogawa Y, Shimmura S, Dogru M, Tsubota K.
    • Journal Title

      Ocular graft versus host disease. Cornea. 29

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Journal Article] Simultaneous deep anterior lamellar keratoplasty (DALK) and limbal allograft (KLAL) in bilateral limbal stem cell deficiency.2010

    • Author(s)
      Omoto M, Shimmura S, Tsubota K, et al.
    • Journal Title

      Jpn J Ophthalmol. in press.

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791712
  • [Journal Article] Immune processes and pathogenic fibrosis in ocular chronic graft versus host disease and clinical manifestations after allogeneic hematopoietic stem cell transplantation.2010

    • Author(s)
      Ogawa Y, Shimmura S, Dogru M, Tsubota K.
    • Journal Title

      Cornea

      Volume: 29

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Journal Article] The role of oxidative stress and inflammation in conjunctivochalasis.2010

    • Author(s)
      Ward SK, Wakamatsu TH, Dogru M, Ibrahim OM, Kaido M, Ogawa Y, Matsumoto Y, Igarashi A, Ishida R, Shimazaki J, Schnider C, Negishi K, Katakami C, Tsubota K
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 51 Pages: 1994-2002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Journal Article] Lacrimal hypofunction as a new mechanism of dry eye in visual display terminal users.2010

    • Author(s)
      Nakamura S, Kinoshita S, Yokoi N, Ogawa Y, Shibuya M, Nakashima H, R.Hisamura R, Imada T, Imagawa T, Uehara M, Shibuya I, Dogru M, Ward S, Tsubota K.
    • Journal Title

      PLoS One

      Volume: 5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Journal Article]2009

    • Author(s)
      坪田一男, 根岸一乃編, 小川葉子
    • Journal Title

      慶應義塾大学薬学部 薬剤師継続学習通信講座 第IV講座 外来で診る眼科疾患(慶應義塾大学出版会株式会社)

      Pages: 51-68

    • Data Source
      KAKENHI-PROJECT-20592058
  • [Journal Article] Retinal phototoxicity in a novel murine model of intraocular lens implantation2009

    • Author(s)
      大本雅弘、坪田一男, ら
    • Journal Title

      Molecular Vision Volume 15

      Pages: 2751-2761

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791712
  • [Journal Article] Epithelial mesenchymal transition in human ocular chronic graft-versus-host disease.2009

    • Author(s)
      Ogawa Y, Shimmura S, Kawakita T, Yoshida S, Kawakami Y, Tsubota K.
    • Journal Title

      Am.J.Pathol. 175

      Pages: 2372-2381

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Journal Article] Tear function and lipid layer alterations in dry eye patients with chronic graft-vs-host disease.2009

    • Author(s)
      Ban Y, Ogawa Y, Goto E, Uchino M, Terauchi N, Seki M, Nakaya M, Saiki M, Mori T, Okamoto S, Matsumoto Y. Dogru M, Shimazaki J, Tsubota K.
    • Journal Title

      Eye.(Corresponding author) 23

      Pages: 202-208

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Journal Article] Retinal phototoxicity in a novel murine model of intraocular lens implantation.2009

    • Author(s)
      Kurihara T, Omoto M, Tsubota K, et al.
    • Journal Title

      Mol Vis. 12,15

      Pages: 2751-2761

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791712
  • [Journal Article] Epithelial mesenchymal transition in human ocular chronic graft-versus-host disease2009

    • Author(s)
      Ogawa Y, Shimmura S, Kawakita T, Yoshida S, Kawakami Y, Tsubota K.
    • Journal Title

      Am J Pathol 175

      Pages: 2372-2381

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Journal Article] Mini-review.Inflammation and pathogenic fibrosis in human ocular chronic graft versus host disease.2008

    • Author(s)
      Ogawa Y, Shimmura S, Kuwana M, Yamazaki K, Kawakami Y, Tsubota K.
    • Journal Title

      Inflammation and regeneration. 28

      Pages: 533-540

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Journal Article] The use of human mesenchymal stem cell-derived feeder cells for the cultivation of transplantable epithelial sheets.2008

    • Author(s)
      Omoto M, Miyashita H, Shimmura S, Tsubota K, et al.
    • Journal Title

      Invest Ophthalmol Vis Sci. 50(5)

      Pages: 2109-2115

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791712
  • [Journal Article] Side population法によるマウス涙腺・唾液腺幹細胞の同定分子リウマチ2006

    • Author(s)
      美島健二, 坪田一男, 斎藤一郎
    • Journal Title

      分子リウマチ 3

      Pages: 31-35

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591930
  • [Journal Article] Alterations of the ocular surface epithelial nucins 1, 2, 4 and the tear functions in patients with atopic keratoconjunctivitis2006

    • Author(s)
      Dogru M, Okada N, Kato N, Igarashi A, Fukagawa K, Shimazaki J, Tsubota K, Fujishima H.
    • Journal Title

      Clinical and Experimental Allergy 36

      Pages: 1556-1565

    • Data Source
      KAKENHI-PROJECT-17591854
  • [Journal Article] Alterations of the ocular surface epithelial mucins 1, 2, 4 and the tear functions in patients with atopic keratoconjunctivitis2006

    • Author(s)
      Dogru, M, Okada, N, Kato, N, Igarashi, A, Fukagawa, K, Shimazaki, J, Tsubota, K, Fujishima, H
    • Journal Title

      Clinical and Experimental Allergy 36

      Pages: 1556-1565

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591854
  • [Journal Article] Identification of lacrimal and salivary gland stem cell by a side population method2006

    • Author(s)
      Mishima K Tsubota K, Saito I.
    • Journal Title

      Bunshi Riumachi 3

      Pages: 31-35

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591930
  • [Patent] 近視進行抑制剤および抑制法としてのM2マクロファージ誘導剤2022

    • Inventor(s)
      坪田一男、栗原俊英、池田真一、コ サイ
    • Industrial Property Rights Holder
      坪田一男、栗原俊英、池田真一、コ サイ
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2022-072596
    • Filing Date
      2022
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Patent] 近視を予防または治療するための方法および組成物2022

    • Inventor(s)
      坪田一男、栗原俊英、ジョン ホヌク、チョウ エン、森紀和子
    • Industrial Property Rights Holder
      坪田一男、栗原俊英、ジョン ホヌク、チョウ エン、森紀和子
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2022-014160
    • Filing Date
      2022
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Patent] 近視予防物品2021

    • Inventor(s)
      坪田一男、根岸一乃、鳥居秀成、栗原俊英
    • Industrial Property Rights Holder
      坪田一男、根岸一乃、鳥居秀成、栗原俊英
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Acquisition Date
      2022
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Patent] LIGHT SOURCE FOR MYOPIA-SUPPRESSING ARTICLE AND METHOD FOR USING LIGHT SOURCE FOR MYOPIA-SUPPRESSING ARTICLE2021

    • Inventor(s)
      山川昌彦、鳥居秀成、栗原俊英、坪田一男
    • Industrial Property Rights Holder
      山川昌彦、鳥居秀成、栗原俊英、坪田一男
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Acquisition Date
      2021
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Patent] GLASS2021

    • Inventor(s)
      永井研輔、中島哲也、坪田一男、栗原俊英、鳥居秀成
    • Industrial Property Rights Holder
      永井研輔、中島哲也、坪田一男、栗原俊英、鳥居秀成
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Acquisition Date
      2021
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Patent] 強膜菲薄化治療用点眼剤及び強膜菲薄化治療剤のスクリーニング方法2021

    • Inventor(s)
      坪田一男、栗原俊英、池田真一、森紀和子、姜效炎
    • Industrial Property Rights Holder
      坪田一男、栗原俊英、池田真一、森紀和子、姜效炎
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Patent] 波長選択透過性ガラス物品2021

    • Inventor(s)
      平社英之、眞下尚洋、永井研輔、坪田一男、栗原俊英、鳥居秀成
    • Industrial Property Rights Holder
      平社英之、眞下尚洋、永井研輔、坪田一男、栗原俊英、鳥居秀成
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Acquisition Date
      2021
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Patent] 食品用組成物2021

    • Inventor(s)
      坪田一男、栗原俊英
    • Industrial Property Rights Holder
      坪田一男、栗原俊英
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Acquisition Date
      2021
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Patent] 近視抑制用点眼剤2021

    • Inventor(s)
      ジョン ホヌク、栗原俊英、坪田一男
    • Industrial Property Rights Holder
      ジョン ホヌク、栗原俊英、坪田一男
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Acquisition Date
      2021
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Patent] 小児の近視進行抑制用点眼剤及び小児の近視進行抑制剤のスクリーニング方法2021

    • Inventor(s)
      坪田一男、栗原俊英、池田真一、森紀和子、姜效炎
    • Industrial Property Rights Holder
      坪田一男、栗原俊英、池田真一、森紀和子、姜效炎
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Patent] 脈絡膜の菲薄化抑制装置及び方法2021

    • Inventor(s)
      姜效炎、森紀和子、栗原俊英、坪田一男
    • Industrial Property Rights Holder
      姜效炎、森紀和子、栗原俊英、坪田一男
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-116584
    • Filing Date
      2021
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Patent] Phenyl butyric acidによる慢性移植片対宿主病における炎症と線維化の抑制と新規治療法の開発2016

    • Inventor(s)
      向井慎、小川葉子、坪田一男
    • Industrial Property Rights Holder
      向井慎、小川葉子、坪田一男
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-04-05
    • Overseas
    • Data Source
      KAKENHI-PROJECT-26462668
  • [Presentation] Violet Light Hypothesis for the Prevention of Myopia.2023

    • Author(s)
      Tsubota K.
    • Organizer
      Visual Health Forum of the South of Five Ridges (virtual).
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] Violet light hypothesis and its possible mechanism for myopia progression.2023

    • Author(s)
      Tsubota K.
    • Organizer
      27th Congress of Chinese Ophthalmological Society.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] Violet light is abundant outdoors but deficient indoors in modern lifestyle in Tokyo.2023

    • Author(s)
      Tsubota K, Kondo S, Jiang X, Torii H, Mori K, Kurihara T.
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) 2023 Annual Meeting.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] Violet Light Hypothesis for the Control of Myopia Progression.2023

    • Author(s)
      Tsubota K.
    • Organizer
      American Academy of Ophthalmology Annual Meeting, Current Approaches to Myopia Control Symposium, Whitney G Sampson Lecture.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] 東京都内における屋内外のバイオレットライトの定量的評価.2023

    • Author(s)
      坪田 一男
    • Organizer
      第5回日本近視学会総会
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] Violet Light Hypothesis for Myopia Control.2023

    • Author(s)
      Tsubota K.
    • Organizer
      Vision China 2023 (online).
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] Ginkgo Biloba Extracts Altered Choroidal Blood Perfusion in Mice.2022

    • Author(s)
      Jing Hou, Kiwako Mori, Shin-ichi Ikeda, Heonuk Jeong, Hidemasa Torii, Kazuno Negishi, Toshihide Kurihara, Kazuo Tsubota
    • Organizer
      The 18th International Myopia Conference (IMC)
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] イチョウ葉エキスがEGR1活性および脈絡膜血 流に与える影響についての検討.2022

    • Author(s)
      侯靖, 森紀和子, 池田真一, 丁憲煜, 鳥居秀成, 根岸一乃, 栗原俊英, 坪田一男.
    • Organizer
      第126回日本眼科学会総会
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] 非視覚系オプシンによる健康イノベーション2022

    • Author(s)
      坪田一男
    • Organizer
      日本抗加齢医学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] The Importance of Light Response in Myopia2022

    • Author(s)
      Kazuo Tsubota
    • Organizer
      66th Brazilian Congress of Ophthalmology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] Light for Health2022

    • Author(s)
      Tsubota Kazuo
    • Organizer
      2nd European Dry Eye Society Congress
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] Violet light can suppress myopia progression in mice, chicks and humans2022

    • Author(s)
      Kazuo Tsubota
    • Organizer
      Juzhou Symposium & International Myopia Conference
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] 網膜色素上皮特異的VEGF欠損 マウスでの眼軸長伸長2022

    • Author(s)
      丁憲煜, 栗原俊英, 張エン, 森紀和子, 池田真一, 馬子妍, 久保田義顕, 根岸一乃, 坪田一男
    • Organizer
      第126回日本眼科学会総会
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] レンズ誘導近視モデルマウスにおけるVL透過率による近視進行抑制効果の差異2022

    • Author(s)
      丁憲煜, 栗原俊英, 馬子妍, 姜効炎, 近藤眞一郎, 植野雄介, 林祐樹, 池田真一, 森紀和子, 鳥居秀成, 根岸一乃, 坪田一男
    • Organizer
      第4回日本近視学会総会
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] Post Lens-Induced-Myopia Emmetropization: Binocular Compensation in Progression And Recovery of Myopia.2022

    • Author(s)
      Ziyan Ma, Heonuk Jeong, Xiaoyan Jiang, Shin-Ichi Ikeda, Kazuno Negishi, Toshihide Kurihara, Kazuo Tsubota
    • Organizer
      The 18th International Myopia Conference (IMC)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] EPA代謝物の脈絡膜菲薄化および近視抑制効果に与える影響2022

    • Author(s)
      栗原俊英, 森 紀和子, 黒羽 小羊子, 侯 靖, 丁 憲煜, 小川 護, 池田 真一, Jing Kang, 鳥居 秀成, 有田 誠, 根岸 一乃, 坪田 一男
    • Organizer
      第126回日本眼科学会総会
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] Role of VEGF Secreted from Retinal Pigment Epithelium in Choriocapillaris and Axial Length Maintenance.2022

    • Author(s)
      Yan Zhang、Heonuk Jeong、Kiwako Mori、Shin-Ichi Ikeda、Chiho Shoda、Yukihiro Miwa、Ayaka Nakai、Junhan Chen、Ziyan Ma、Xiaoyan Jiang、Hidemasa Torii、Yoshiaki Kubota、Kazuno Negishi、Toshihide Kurihara、Kazuo Tsubota
    • Organizer
      The 18th International Myopia Conference (IMC)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] Bunazosin inhibited axial elongation with an increase of the choroidal blood perfusion in a murine model of myopia2022

    • Author(s)
      Heonuk Jeong, Toshihide Kurihara, Xiaoyan Jiang, Kazuno Negishi, Kazuo Tsubota
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) 2022 Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] A Randomized Controlled Trial for The Effect of Violet Light Transmitting Eyeglasses on Myopia Progression In Children2022

    • Author(s)
      Kiwako Mori, Hidemasa Torii, Yutaka Hara, Michiko Hara, Erisa Yotsukura, Akiko Hanyuda, Kazuno Negishi, Toshihide Kurihara, Kazuo Tsubota
    • Organizer
      The 18th International Myopia Conference (IMC)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] Lrp2ノックアウトマウスが示す強度近視の分子機 構解析.2022

    • Author(s)
      張エン, 栗原俊英, 丁憲煜, 森紀和子, 池田真一, 陳俊翰, 根岸一乃, 坪田一男
    • Organizer
      第126回日本眼科学会総会
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] Violet light hypothesis for myopia control2022

    • Author(s)
      Kazuo Tsubota
    • Organizer
      1st International Symposium of the Biology of the Non-Visual Opsins
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] Ginkgo biloba Extracts Showed Myopia Suppressive Effects in a Lens-Induced Myopia Model in Mice2022

    • Author(s)
      Jing Hou, Kiwako Mori, Shin-ichi Ikeda, Heonuk Jeong, Hidemasa Torii, Kazuno Negishi, Toshihide Kurihara, Kazuo Tsubota
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) 2022 Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] Alpha-1 Blockers Suppress Lens-Induced Myopia in Mice by Maintenance of Choroidal Thickness2022

    • Author(s)
      Heonuk Jeong, Toshihide Kurihara, Xiaoyan Jiang, Kazuno Negishi, Kazuo Tsubota
    • Organizer
      The 18th International Myopia Conference (IMC)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] バイオレット光透過眼鏡を用い た2年間の無作為化二重盲検比較試験2022

    • Author(s)
      森紀和子, 鳥居秀成, 原裕, 原道子, 四倉絵里沙, 羽入田明子, 根岸一乃, 栗原俊英, 坪田一男
    • Organizer
      第126回日本眼科学会総会
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] Omega 3 polyunsaturated fatty acids showed suppression of choroidal thinning and subsequent myopia inhibition by lipidomic analysis in murine experimental models.2022

    • Author(s)
      Toshihide Kurihara, Kiwako Mori, Sayoko Kuroha, Jing Hou, Heonuk Jeong, Mamoru Ogawa, Shin-Ichi Ikeda, Jing X Kang, Kazuno Negish, Hidemasa Torii, Makoto Arita, Kazuo Tsubota
    • Organizer
      The 18th International Myopia Conference (IMC)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] イチョウ葉エキスのマウス実験近視モデル2021

    • Author(s)
      侯靖,森紀和子,池田真一,丁憲燈,張淡,馬子妍,陳俊翰,鳥居秀成,栗原俊英,坪田一男
    • Organizer
      第3回日本近視学会総会
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] Bio-Antiaging by Outdoor Light.2021

    • Author(s)
      Tsubota K.
    • Organizer
      Silicon Valley Japan Platform (SVJP) Online Meetup Series "Matcha"
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] 近視児童における眼軸長と涙液層破壊時間との関連性2021

    • Author(s)
      坪田一男,鳥居秀成,ハズラデバブラタ,森紀和子,羽入田明子,篠島亜里,池田真一,姜奴炎,丁憲燈,四倉絵里沙,栗原俊英
    • Organizer
      第3回日本近視学会総会
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] バイオレットライトはOPN5を介してマウス実験近視を抑制する2021

    • Author(s)
      栗原俊英,姜奴炎,Machelle Pardue,森紀和子,池田真一,鳥居秀成,Shane D'Souza, Richard Lang,坪田一男
    • Organizer
      第3回日本近視学会総会
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] 強膜小胞体ストレスによる近視進行制御2021

    • Author(s)
      池田真一,栗原俊英,姜効炎,森紀和子,丁憲燈,堅田侑作,國見洋光,三輪幸裕,小澤信博,伊吹麻里,正田千穂,鳥居秀成,坪田一男
    • Organizer
      第3回日本近視学会総会
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] バイオレットライト照射眼鏡の短期安全性ー無作為化二重盲検比較探索的臨床試験一2021

    • Author(s)
      鳥居秀成,岡野敬,楊浩勇,四倉絵里沙,森紀和子,羽入田明子,篠島亜里,池田真一,近藤員一郎,根岸一乃,栗原俊英,坪田一男
    • Organizer
      第3回日本近視学会総会
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice.2021

    • Author(s)
      Kurihara T, Jiang X, Pardue M, Mori K, Ikeda SI, Torii H, D'Souza S, Lang RA, Tsubota K.
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] 東京都内1幼稚園の6歳児における眼軸長と高次収差の関連性の検討2021

    • Author(s)
      四倉絵里沙,鳥居秀成,森紀和子,羽入田明子,根岸一乃,栗原俊英,坪田一男
    • Organizer
      第3回日本近視学会総会
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] Selective Ablation of Lrp2 in Retinal Pigment Epithelium Causes High Myopia.2021

    • Author(s)
      張淡,栗原俊英,丁憲燈,森紀和子,池田真一,伴紀充,鳥居秀成,坪田一男
    • Organizer
      第3回日本近視学会総会
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] 東京都内1小学校における1年間の屈折値、眼軸長変化量とその関連因子の検討2021

    • Author(s)
      清水奈津子,四倉絵里沙,鳥居秀成,森紀和子,羽入田明子,内野美樹,根岸一乃,栗原俊英,坪田一男
    • Organizer
      第125回日本眼科学会総会
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] Violet Light Can Suppress Myopia Progression in Mice, Chick, and Human.2021

    • Author(s)
      Tsubota K, Torii H, Jiang X, Kurihara T.
    • Organizer
      2021 Myopia Update Symposium in Taiwan (MUSIT)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] How do you treat a four-year-old child with high myopia?2021

    • Author(s)
      Tsubota K.
    • Organizer
      University of Illinois at Chicago (UIC) Grand Rounds
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] Dry Eye & Myopia are Related!!!2021

    • Author(s)
      Tsubota K.
    • Organizer
      Asia Dry Eye Society Educational Session 2021
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] COVID-19流行前後の都内小学生における眼軸 長変化量と関連因子の検討2021

    • Author(s)
      四倉絵里沙,鳥居秀成,森紀和子,小川護,羽入田明子,根岸一乃,栗原俊英,坪田一男
    • Organizer
      第75回日本臨床眼科学会
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] OPNを介したバイオレットライトによる血管内皮増殖因子の発現2021

    • Author(s)
      丁憲燈,栗原俊英,池田真一,姜効炎,森紀和子,鳥居秀成,坪田一男
    • Organizer
      第3回日本近視学会総会
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] 眼軸長と体の各部位の長さとの相関と男女差2021

    • Author(s)
      篠島亜里,栗原俊英,森紀和子,岩井佑二郎,羽入田明子,鳥居秀成,坪田一男
    • Organizer
      第3回日本近視学会総会
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] 眼鏡装用時に眼に入る太陽光バイオレットライトの塁:マネキン測定の解析2021

    • Author(s)
      近藤眞一郎,姜奴炎,大塚直輝,金田大輔,鳥居秀成,栗原俊英,坪田一男
    • Organizer
      第3回日本近視学会総会
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] マウス近視モデルにおけるオメガ3不飽和脂肪酸の近視進行抑制効果2021

    • Author(s)
      森紀和子,黒羽小羊子,侯靖,丁憲燈,池田真一,小川護,鳥居秀成,有田誠,栗原俊英,坪田一男
    • Organizer
      第3回日本近視学会総会
    • Data Source
      KAKENHI-PROJECT-21H03096
  • [Presentation] FK866 Compromises Mitochondrial Metabolism in iPS derived Neural Crest Stem cells2020

    • Author(s)
      佐矢野智子,稲垣絵海,菅井恵津子,岡野栄之,榛村重人,坪田一男
    • Organizer
      第19回日本再生医療学会総会
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] ラット急性虚血障害モデルにおけるNAD関連代謝産物の網膜保護効果2020

    • Author(s)
      菅井 恵津子,稲垣 絵海,中村 滋,今田 敏弘,泉田 祐輔,榛村 重人,岡野 栄之,坪田 一男
    • Organizer
      第19回日本再生医療学会総会
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] フックス角膜内皮変性症患者由来iPS細胞を用いた疾患モデルの構築2020

    • Author(s)
      稲垣絵海, 佐矢野智子, 山崎梨沙,菅井恵津子,房木ノエミ, 羽藤晋, 岡野栄之, 坪田一男,榛村重人.
    • Organizer
      第19回日本再生医療学会総会
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] 光と健康を科学する2019

    • Author(s)
      坪田一男
    • Organizer
      第12回北大阪眼科フォーラム.
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] 光と健康.2019

    • Author(s)
      坪田一男
    • Organizer
      日本セルフケア推進協議会設立記念講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] Short BUT Dry Eye.2019

    • Author(s)
      坪田一男
    • Organizer
      第13回箱根ドライアイクラブ.
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] アンチエイジングアップデート20192019

    • Author(s)
      坪田一男
    • Organizer
      抗加齢医学の実際2019
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] NAD related metabolites and its possible application for corneal disease.2019

    • Author(s)
      Inagaki E, Shimmura S, Sugai E, Hatou S, Okano H, Tsubota K.
    • Organizer
      Corneal Conference, international session
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] NAD related metabolites and its possible application for corneal disease2019

    • Author(s)
      Inagaki E, Shimmura S, Sugai E, Hatou S, Okano H, Tsubota K.
    • Organizer
      Japan Corneal Conference , international session
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] アンチエイジングアップデート20192019

    • Author(s)
      坪田一男
    • Organizer
      第15回キレーション治療セミナー(応用編)
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] アンチエイジングアップデート2019

    • Author(s)
      坪田一男
    • Organizer
      第10回慶應義塾生命科学シンポジウム食と医科学フォーラム
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] 健康長寿に向けたNAD関連中間代謝物の前眼部恒常性維持機構の解明. 第19 回日本抗加齢医学会総会最優秀演題講演. 横浜. 2019/6/14.2019

    • Author(s)
      稲垣絵海, 菅井恵津子, 榛村重人, 羽藤晋, 岡野栄之, 坪田一男.
    • Organizer
      第19 回日本抗加齢医学会総会 優秀演題賞受賞講演
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] Altered Aging Phenotypes in Human iPSC Derived Corneal Endothelial Cells from Patients with Fuchs’ Endothelial Corneal Dystrophy2019

    • Author(s)
      Inagaki E, Sayano T, Yamazaki R, Fusaki N, Hatou S, Fujinami K, Sugai E, Okano H, Tsubota K, Shimmura S.
    • Organizer
      The 10th Association of Pacific-Rim Universities (APRU) Population Aging Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] 食品含有成分, NMN (nicotinamide mononucleotide)の高感度分析法の開発と霊長類モデルにおける体内動態の解明2019

    • Author(s)
      稲垣絵海, 廣瀬枝実子, 菅井恵津子, 後藤恵子, 芝田晋介, 羽藤晋, 榛村重人, 佐藤泰憲, 中村紳一郎, 岡野栄之, 坪田一男.
    • Organizer
      日本食品化学学会第25回総会・学術大会
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] Corneal TRPV1 Signal Accelerates Lacrimal Gland Maturation.2019

    • Author(s)
      Tsubota K.
    • Organizer
      Asia Dry Eye Summit 2019.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] 老化研究からのイノベーション2019

    • Author(s)
      坪田一男
    • Organizer
      第30回日本臨床口腔病理学会合同学術大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] 光の健康効果を科学する!2019

    • Author(s)
      坪田一男
    • Organizer
      東京都眼科集談会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] 眼を中枢とする老化制御2019

    • Author(s)
      坪田一男
    • Organizer
      2019年度 第1回KGRI基軸プロジェクト・長寿 進捗報告会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] NMN (nicotinamide mononucleotide)による網膜保護作用.2019

    • Author(s)
      稲垣絵海, 中村滋, 菅井恵津子, 泉田祐輔, 今田敏博, 結城賢弥, 榛村重人, 芝田晋介, 岡野栄之, 坪田一男
    • Organizer
      第30回日本緑内障学会
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] 目の環境をコントロールする!2019

    • Author(s)
      坪田一男
    • Organizer
      東京眼科サミット2019
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] Regulation of Aging Related Diseases via Optimal Nutrition and Light.2019

    • Author(s)
      坪田一男
    • Organizer
      慶應-ケルン合同シンポジウム2019
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] 光の健康を科学する.2019

    • Author(s)
      坪田一男
    • Organizer
      第32回上越臨床眼科フォーラム学術講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] SCIENCE of Tearing~涙のサイエンス~2019

    • Author(s)
      坪田一男
    • Organizer
      フォーサム2019
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] 目からのエイジングアプローチ2019

    • Author(s)
      坪田一男
    • Organizer
      第51回ヒューマンサイエンス総合研究セミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] NAD related metabolites and its possible application for corneal disease.2019

    • Author(s)
      Emi Inagaki, Shigeto Shimmura, Etsuko Sugai, Shin Hatou, Hideyuki Okano, Kazuo Tsubota.
    • Organizer
      Japan Cornea Conference 2019 43nd Japan Cornea Society / 35th Annual Meeting of Keratoplasty Society of Japan
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] Altered Aging Phenotypes in Human iPSC Derived Corneal Endothelial Cells from Patients with Fuchs’ Endothelial Corneal Dystrophy.2019

    • Author(s)
      Inagaki E, Sayano T, Yamazaki R, Fusaki N, Hatou S, Fujinami K, Sugai E, Okano H, Tsubota K, Shimmura S.
    • Organizer
      The 10th Association of Pacific-Rim Universities (APRU) Population Aging Conference.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] The Science of Tearing2019

    • Author(s)
      Tsubota K.
    • Organizer
      6th Evolving Practice of Ophthalmology Middle East Conference.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] Clinical Definition of Dry Eye Disease: A Proposal by an International Expert Panel.2019

    • Author(s)
      Tsubota K.
    • Organizer
      International Ocular Surface Society (IOSS).
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] 目からのエイジングアプローチ.2019

    • Author(s)
      坪田一男
    • Organizer
      第51回ヒューマンサイエンス総合研究セミナー.
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] Causes and Consequences of Tear Film Break up.2019

    • Author(s)
      Tsubota K.
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) 2019 Annual Meeting.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] ドライアイの最近の流れとアジアの意義について2019

    • Author(s)
      坪田一男
    • Organizer
      Asia Dry Eye Summit 2019.
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] Light for Health.2019

    • Author(s)
      Tsubota K.
    • Organizer
      Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] ドライアイ2018

    • Author(s)
      坪田一男
    • Organizer
      第122回日本眼学会会総会市民公開講座
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] Asia Dry Eye Society 最新情報2018

    • Author(s)
      坪田一男
    • Organizer
      第12回箱根ドライアイクラブ
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] アンチエイジングアップデート20182018

    • Author(s)
      坪田一男
    • Organizer
      第18回抗加齢医学の実際
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] Science of Tearing2018

    • Author(s)
      Tsubota K
    • Organizer
      Asia Dry Eye Summit 2018
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] Science of Tearing2018

    • Author(s)
      Tsubota K
    • Organizer
      Gordon Research Conference: Cornea & Ocular Surface Biology & Pathology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] Science of Tearing2018

    • Author(s)
      Tsubota K
    • Organizer
      The 36th World Ophthalmology Congress (WOC). Barcelona
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] ドライアイ研究のニューホライズン2018

    • Author(s)
      坪田一男
    • Organizer
      第12回箱根ドライアイクラブ
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] New insights on the role of light in ocular development and pathologies2018

    • Author(s)
      Tsubota K
    • Organizer
      Journées de Réflexions Ophtalmologiques
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] In-vivo imaging of pluripotent stem cell differentiation using the anterior chamber of the eye2018

    • Author(s)
      Inagaki E, Hatou S, Miyashita H, Arai E, Izuta Y, Kanai Y, Okano H, Tsubota K, Shimmura S
    • Organizer
      The International Society for Stem Cell Research (ISSCR) Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] 涙のサイエンス2018

    • Author(s)
      坪田一男
    • Organizer
      第18回日本抗加齢医学会総会ランチョンセミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] The Anti-Aging Approach for Ocular Disorders.2017

    • Author(s)
      Tsubota K
    • Organizer
      French-Japanese Scientific Meeting on Neurobiology of Diseases and Ageing.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] Aging Approach for the Treatment of Dry Eye.2017

    • Author(s)
      Tsubota K
    • Organizer
      ARVO-Asia. Brisbane, Australia, 5-8 February 2017
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] Age-Associated Eye Disorders and their Treatment.2017

    • Author(s)
      Tsubota K
    • Organizer
      Keystone Symposia: Aging and Mechanisms of Aging-Related Disease. Yokohama, Japan, 15-19 May 2017
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] アンチエイジングアップデート2017.2017

    • Author(s)
      坪田一男
    • Organizer
      抗加齢医学の実際2017
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] FK866 compromises mitochondrial metabolism in iPS derived neural crest stem cells.2017

    • Author(s)
      Inagaki E, Miyoshi M, Shimmura S, Yoshida S, Tsubota K, Okano H.
    • Organizer
      ISSCR( International Society for Stem Cell Research) 2017 Boston
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] 光環境とアンチエイジング医学2017

    • Author(s)
      坪田一男
    • Organizer
      第17回日本抗加齢医学会総会理事長提言. 東京. 2017/6/3
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] セマフォリン3A阻害薬ビナキサントンによる新規ドライアイ治療の可能性2017

    • Author(s)
      山崎 梨沙、山添 克弥、吉田  悟、羽藤  晋、稲垣 絵海、岡野 栄之、坪田 一男、榛村 重人
    • Organizer
      角膜カンファランス2018
    • Data Source
      KAKENHI-PROJECT-16K11299
  • [Presentation] アンチエイジングアップデート2017

    • Author(s)
      坪田一男
    • Organizer
      第8回食と医科学フォーラム. 東京. 2017/12/6.
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] 炎症と目のエイジング -Inflammation and Aging of the Eye-.2017

    • Author(s)
      坪田一男
    • Organizer
      第38回日本炎症・再生医学会シンポジウム. 大阪. 2017/7/18.
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] アンチエイジング医学 最新の知見.2017

    • Author(s)
      坪田一男
    • Organizer
      第71回日本臨床眼科学会ランチョンセミナー. 東京. 2017/10/12.
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] 炎症と目のエイジング -Inflammation and Aging of the Eye-.2017

    • Author(s)
      坪田一男
    • Organizer
      第59回日本老年医学会学術集会シンポジウム. 名古屋. 2017/6/15.
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] NAD-related Metabolites and their possible application for corneal disease.2017

    • Author(s)
      Inagaki E, Miyoshi M, Izuta Y, Nakamura S, Hatou S, Shimmura S, Tsubota K and Okano H
    • Organizer
      Keystone Symposia: Aging and Mechanisms of Aging-Related Disease. Yokohama, Japan, 15-19 May 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] Ketone body 3-hydroxybutyrateYusuke Izuta, Toshihiro Imada, Ryuji Hisamura, Shigeru Nakamura, Kazuo Tsubota. mimics calorie restriction via Nrf2 activator fumarate in retina2017

    • Author(s)
      Izuta Y, Imada T, Hisamura R, Oonishi E, Nakamura S, Inagaki E, Ito M, Soga T, Tsubota K.
    • Organizer
      Keystone Symposia: Aging and Mechanisms of Aging-Related Disease. Yokohama, Japan, 15-19 May 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] 健康長寿を目指したNAD関連代謝産物による前眼部の代謝制御2017

    • Author(s)
      稲垣絵海、三好浩之、羽藤晋、榛村重人、坪田一男、岡野栄之
    • Organizer
      第38回日本炎症・再生医学会 大阪
    • Data Source
      KAKENHI-PROJECT-17H04353
  • [Presentation] Development of a transgenic mouse with R124H human TGFBI mutation associated with Avellino corneal dystrophy2015

    • Author(s)
      Yamazoe K, Yoshida S, Hatou S, Yasuda M, Inagaki E, Ogawa Y, Tsubota K, Shimmura S. .
    • Organizer
      The Annual Meeting of Association for Research in Vision and Ophthalmology 2015 (ARVO2015)
    • Place of Presentation
      Denver, USA
    • Year and Date
      2015-05-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462668
  • [Presentation] 眼慢性移植片対宿主病における小胞体ストレスの関与.2015

    • Author(s)
      小川葉子、向井慎、坪田一男.
    • Organizer
      第15回 日本抗加齢医学会総会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市博多区)
    • Year and Date
      2015-05-29
    • Data Source
      KAKENHI-PROJECT-26462668
  • [Presentation] 慢性移植片対宿主病によるドライアイの臨床像と末梢血免疫担当細胞の活性化の関連性.2015

    • Author(s)
      山根みお, 小川葉子, 林 勇海, 福井正樹, 向井 慎, 坪田一男.
    • Organizer
      第69回日本臨床眼科学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市熱田区)
    • Year and Date
      2015-10-22
    • Data Source
      KAKENHI-PROJECT-26462668
  • [Presentation] マウスGVHD涙腺における免疫担当細胞の相互作用.2015

    • Author(s)
      山根みお, 小川葉子, 鈴木孝典, 向井慎, 坪田一男.
    • Organizer
      第36回 日本炎症・再生医学会
    • Place of Presentation
      虎ノ門ヒルズフォーラム(東京都港区)
    • Year and Date
      2015-07-21
    • Data Source
      KAKENHI-PROJECT-26462668
  • [Presentation] Efficacy and safety of tranilast treatment for ocular chronic graft-versus-host disease.2015

    • Author(s)
      Mukai S, Ogawa Y, Saya H, Kawakami Y, Tsubota K.
    • Organizer
      The 18th International Ocular Surface Society Conference.
    • Place of Presentation
      Denver, USA
    • Year and Date
      2015-05-02
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462668
  • [Presentation] 蛍光標識マウス由来細胞を用いた再生涙腺の発生評価2015

    • Author(s)
      平山雅敏, 川北哲也, 榛村重人, 辻孝, 坪田一男
    • Organizer
      第39回日本角膜学会・第31回日本角膜移植学会総会
    • Place of Presentation
      高知、高知市文化プラザかるぽーと
    • Year and Date
      2015-02-11
    • Invited
    • Data Source
      KAKENHI-PROJECT-25242041
  • [Presentation] Reduction of endoplasmic reticulum stress for treatment of ocular chronic graft-versus-host-disease.2015

    • Author(s)
      Mukai S, Ogawa Y, Tsubota K.
    • Organizer
      The Annual Meeting of Association for Research in Vision and Ophthalmology 2015 (ARVO2015)
    • Place of Presentation
      Denver, USA
    • Year and Date
      2015-05-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462668
  • [Presentation] Diagnostic criteria of ocular GVHD2015

    • Author(s)
      Ogawa Y, Tsubota K.
    • Organizer
      The Chicago Chronic GVHD Meeting 2015
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-10-24
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462668
  • [Presentation] 眼慢性移植片対宿主病の国際診断基準の感度と特異度の検討.2015

    • Author(s)
      福井正樹, 小川葉子, レザ ダナ, キム ステラ, ビクター ペレッツ, 立松由佳子, 山根みお, 小川護, 西條裕美子, 鴨居瑞加, 坪田一男.
    • Organizer
      第69回日本臨床眼科学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市熱田区)
    • Year and Date
      2015-10-22
    • Data Source
      KAKENHI-PROJECT-26462668
  • [Presentation] Development of autoimmune type lacrimal gland GVHD in adoptively transferred mice with recipient derived T cells.2015

    • Author(s)
      Ogawa Y, Shimmura S, Tsubota K.
    • Organizer
      The Annual Meeting of Association for Research in Vision and Ophthalmology 2015 (ARVO2015)
    • Place of Presentation
      Denver, USA
    • Year and Date
      2015-05-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462668
  • [Presentation] Adoptive transferによる涙腺慢性GVHD発症機序の解明.2015

    • Author(s)
      小川葉子, 榛村重人, 坪田一男.
    • Organizer
      第119回日本眼科学会総会
    • Place of Presentation
      ロイトン札幌 (北海道札幌市中央区)
    • Year and Date
      2015-04-16
    • Data Source
      KAKENHI-PROJECT-26462668
  • [Presentation] Mismatched mesenchymal stem cells as an initial trigger of ocular chronic graft-versus- host disease following allogeneic bone marrow transplantation.2013

    • Author(s)
      Ogawa Y, Shimmura S, Morikawa S, Okano H, Matsuzaki Y, Tsubota K.
    • Organizer
      The 3rd International Conference on Clinical & Experimental Ophthalmology
    • Place of Presentation
      Chicago/Northbrook, USA
    • Invited
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] Analysis of fibrosis in IgG4-related Mikulicz's disease.2013

    • Author(s)
      Fukui M, Ogawa Y, Shimmura S, Hatou S, Ichihashi Y, Yaguchi S, Hirayama M, Kawakita T, Tsubota K.
    • Organizer
      The 7th International Conference on the Tear Film & Ocular Surface: Basic Science and Clinical Relevance; 18-21 Sep 2013
    • Place of Presentation
      Taormina, Sicily, Italy.
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] Donor mesenchymal stem cells expressing MHC class II molecule trigger immune responses in an animal model of lacrimal gland chronic graft-versus-host disease2013

    • Author(s)
      Ogawa Y, Shimmura S, Yaguchi S, Inaba T, Tsubota K
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) Florida
    • Place of Presentation
      Florida, USA
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] 再生涙腺原基の移植による機能的な涙腺再生2013

    • Author(s)
      山下健太郎、平山雅敏、小川美帆、大島正充、関根由里恵、石田研太郎、川北哲也、坪田一男、辻 孝
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸・神戸ポートアイランド
    • Data Source
      KAKENHI-PROJECT-25242041
  • [Presentation] International chronic ocular graft versus host disease (GVHD) consensus group: Proposal of new diagnostic criteria for chronic GVHD (Part I).2013

    • Author(s)
      Ogawa Y, Kim SK, Dana R, Clayton J, Jain S, Rosenblatt MI, Perez VL, Shikari H, Riemens A, Tsubota K.
    • Organizer
      The 7th International Conference on the Tear Film & Ocular Surface: Basic Science and Clinical Relevance; Taormina, Sicily, Italy. 18-21 Sep 2013
    • Place of Presentation
      Taormina, Sicily, Italy.
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] Donor mesenchymal stem cells expressing MHC class II molecule trigger immune responses in an animal model of lacrimal gland chronic graft-versus-host disease.2013

    • Author(s)
      Ogawa Y, Shimmura S, Yaguchi S, Inaba T, Tsubota K.
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) 2013, 5-9 May 2013
    • Place of Presentation
      Seattle, USA
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] Primary and secondary surveys on epidemiology of Sogren's syndrome in all Japan.2013

    • Author(s)
      Tsuboi H, Asashima H, Umehara H, Kawakami A, Nakamura H, Sano H, Tsubota K, Ogawa Y, Takamura E, Saito I, Inoue H, Nakamura S, Moriyama M, Takeuchi T, Tanaka Y, Hirata S, Mimori T, Ohta A, Matsumoto I, Sumida T.
    • Organizer
      The 12th International Symposium on Sjogren's Syndrome
    • Place of Presentation
      Kyoto, JAPAN
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] Mismatched mesenchymal stem cells as an initial trigger of ocular chronic graft-versus- host disease following allogeneic bone marrow transplantation2013

    • Author(s)
      Ogawa Y, Shimmura S, Morikawa S, Okano H, Matsuzaki Y, Tsubota K
    • Organizer
      The 3rd International Conference on Clinical & Experimental Ophthalmology Hilton Chicago/Northbrook
    • Place of Presentation
      USA
    • Year and Date
      2013-04-14
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] The regeneration potential of mouse lacrimal gland following duct ligation procedure2013

    • Author(s)
      Liu Y, Kawakita T, Sugiyama M, Hirayama M, Kawashima M, Ogawa Y, Ito M, Shimmura S, Tsubota K.
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) 2013, 5-9 May 2013
    • Place of Presentation
      Seattle, USA
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] Donor mesenchymal stem cells induce immune response in lacrimal gland chronic graft versus host disease in an animal model.2013

    • Author(s)
      Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Sato Y, Suzuki S, Yaguchi T, Inaba, T, Yaguchi S, Okamoto S, Kawakami Y, Okano H, Maztsuzaki Y, Tsubota K.
    • Organizer
      The 12th International Symposium on Sjogren's Syndrome
    • Place of Presentation
      Kyoto, JAPAN
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] Donor mesenchymal stem cells induce immune response in lacrimal gland chronic graft versus host disease in an animal model2013

    • Author(s)
      Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Sato Y, Suzuki S, Yaguchi T, Inaba, T, Yaguchi S, Okamoto S, Kawakami Y, Okano H, Maztsuzaki Y, Tsubota K
    • Organizer
      The 12th International Symposium on Sjögren's Syndrome
    • Place of Presentation
      Kyoto , Japan
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] New challenges for dry eye.2012

    • Author(s)
      坪田一男
    • Organizer
      TFOS in asia
    • Place of Presentation
      神奈川
    • Invited
    • Data Source
      KAKENHI-PROJECT-22390326
  • [Presentation] A role of recipient-derived T cells in ocular chronic graft-versus-host disease.2012

    • Author(s)
      Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Yaguchi Y, Inaba T, Kawakami Y, Okano H, Matsuzaki Y, Tsubota K.
    • Organizer
      1st Conference on the Tear Film and Ocular Surface in Asia,
    • Place of Presentation
      Kanagawa, Japan
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] Minor antigen-mismatched MSC react with residual host T cells to trigger the progression of chronic GVHD.2012

    • Author(s)
      Matsuzaki Y, Ogawa Y, Morikawa S, Okano H, Tsubota K, Shimmura S.
    • Organizer
      International Society of Stem Cell Research (ISSCR) 10th Annual Meeting,
    • Place of Presentation
      Yokohama, Japan.
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] 自己免疫疾患様反応を示す眼慢性GVHDマウスモデルのT細胞と間葉系幹細胞の相互作用2012

    • Author(s)
      小川葉子, 榛村重人, 森川暁, 馬渕洋, 谷口智憲, 谷口紗織, 稲葉隆明, 岡本真一郎, 河上 裕, 岡野栄之, 松崎有未, 坪田一男..
    • Organizer
      第21回日本シェーグレン症候群学会学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] Minor antigen-mismatched MSC react with residual host T cells to trigger the progression of chronic GVHD2012

    • Author(s)
      Matsuzaki Y, Ogawa Y, Morikawa S, Okano H, Tsubota K, Shimmura S
    • Organizer
      International Society of Stem Cell Research (ISSCR) 10th Annual Meeting
    • Place of Presentation
      Yokohama, Japan
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] Posttranslational modification of mitochondrial proteins by sirtuin during caloric restriction.2012

    • Author(s)
      Shinmura K, Tamaki K, Sano M, Yamamoto T, Fukuda K, Tsubota K.
    • Organizer
      Keystone Symposia: Sirtuins in metabolism, aging and disease.
    • Place of Presentation
      Tahoe City, USA
    • Year and Date
      2012-02-14
    • Data Source
      KAKENHI-PROJECT-22590814
  • [Presentation] Interaction between donor mesenchymal stem cells and recipient-derived T cells in the pathogenesis of ocular chronic graft versus host disease2012

    • Author(s)
      Ogawa Y, Shimmura S, Morikawa S, Yaguchi T, Yaguchi S, Inaba T, Kawakami Y, Okano H, Matsuzaki Y, Tsubota K. .
    • Organizer
      The association for research in vision and ophthalmology 2012 (ARVO 2012) Annual Meeting,
    • Place of Presentation
      Fort Lauderdale, Florida, USA
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] Interaction between donor mesenchymal stem cells and recipient-derived T cells in the pathogenesis of ocular chronic graft versus host disease2012

    • Author(s)
      Ogawa Y, Shimmura S, Morikawa S, Yaguchi T, Yaguchi S, Inaba T, Kawakami Y, Okano H, Matsuzaki Y, Tsubota K
    • Organizer
      The association for research in vision and ophthalmology 2012 (ARVO 2012) Annual Meeting
    • Place of Presentation
      Fort Lauderdale, Florida, USA
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] A role of recipient-derived T cells in ocular chronic graft-versus-host disease2012

    • Author(s)
      Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Yaguchi Y, Inaba T, Kawakami Y, Okano H, Matsuzaki Y, Tsubota K
    • Organizer
      1st Conference on the Tear Film and Ocular Surface in Asia
    • Place of Presentation
      Kanagawa, Japan
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] Cardiac Sirt1 is essential for caloric restriction-induced cardioprotection against ischemia/reperfusion.2012

    • Author(s)
      Shinmura K, Yamamoto T, Tamaki K, Sano M, Fukuda K, Inaba T, Tsubota K.
    • Organizer
      Keystone Symposia: Aging and Diseases of Aging.
    • Place of Presentation
      Tokyo, JAPAN
    • Year and Date
      2012-10-27
    • Data Source
      KAKENHI-PROJECT-22590814
  • [Presentation] Posttranslational modification of mitochondrial proteins by sirtuin during caloric restriction2012

    • Author(s)
      Shinmura K, Tamaki K, Sano M, Yamamoto T, Fukuda K, Tsubota K
    • Organizer
      Keystone Symposia : Sirtuins in metabolism, aging and disease
    • Place of Presentation
      Tahoe city, CA, USA
    • Year and Date
      2012-02-14
    • Data Source
      KAKENHI-PROJECT-22590814
  • [Presentation] New challenges for dry eye.2012

    • Author(s)
      Tsubota K.
    • Organizer
      International Conference on the Tear Film & Ocular Surface in Asia.
    • Place of Presentation
      kanagawa, Japan
    • Data Source
      KAKENHI-PROJECT-22390326
  • [Presentation] マウス角膜移植モデルにおけるSemaphorin 3A阻害薬による神経再生促進2011

    • Author(s)
      大本雅弘・榛村重人・吉田悟・川北哲也・坪田一男
    • Organizer
      第35回日本角膜学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-12
    • Data Source
      KAKENHI-PROJECT-21791712
  • [Presentation] 眼慢性移植片対宿主病におけるドナー由来線維芽細胞の細胞源の検討2011

    • Author(s)
      小川葉子、榛村重人、森川暁、馬渕洋、谷口智憲、鈴木禎史、河上裕、岡野英之、松崎有未、坪田一男
    • Organizer
      角膜カンファレンス2011
    • Place of Presentation
      東京
    • Year and Date
      2011-02-18
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] Role Of Muscarinic Acetylcholine Receptors and Ca2+ Signaling in Tear Secretion.2011

    • Author(s)
      Inaba T, Hisatsune C, Kawakita T, Sasaki Y, Ogawa Y, Mikoshiba K, Tsubota K.
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO), Annual Meeting, 2011
    • Place of Presentation
      Florida, USA
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] Donor mesenchymal stem cells trigger chronic graft-versus-host disease following minor antigen-mismatched bone marrow transplantation2011

    • Author(s)
      Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Yaguchi T, Inaba T, Yaguchi S, Kawakami Y, Okano H, Tsubota K, Matsuzaki Y
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-28
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] Ocular chronic graft-versus-host disease.2011

    • Author(s)
      Ogawa Y, Kamoi M, Uchino M, Ban Y, Yaguchi S, Inagaki E, Tsubota K.
    • Organizer
      1st Ocular cGVHD International Consensus Meeting. KEIO Global Clinical Research Program
    • Place of Presentation
      Florida, USA
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] A Radical Approach to Aging Eye Disease2011

    • Author(s)
      坪田一男
    • Organizer
      Association for Research in Vision and Ophthalmology Annual meeting
    • Place of Presentation
      Fort Lauderdale, FL, USA(招待講演)
    • Data Source
      KAKENHI-PROJECT-22390326
  • [Presentation] ムスカリン性アセチルコリン受容体欠損マウスの涙液分泌角膜カンファランス20112011

    • Author(s)
      稲葉隆明、久恒智博、川北哲也、佐々木恭正、小川葉子、御子柴克彦、坪田一男
    • Organizer
      第35回日本角膜学会総会・第27回日本角膜移植学会
    • Place of Presentation
      品川プリンスホテル,東京
    • Data Source
      KAKENHI-PROJECT-22659312
  • [Presentation] Semaphorin 3A阻害薬による角膜グラフトへの神経再生促進2011

    • Author(s)
      大本雅弘・榛村重人・吉田悟・川北哲也・坪田一男
    • Organizer
      第35回日本角膜学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-02-17
    • Data Source
      KAKENHI-PROJECT-21791712
  • [Presentation] 眼移植片対宿主病(GVHD)モデルマウスにおける涙腺の免疫組織学的検討2011

    • Author(s)
      谷口紗織、小川葉子、榛村重人、坪田一男
    • Organizer
      第115回日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] 生体共焦点顕微鏡による眼慢性GVHD症例のマイボーム腺の観察2011

    • Author(s)
      番裕美子、小川葉子、オサマイブラヒム、立松由佳子、鴨居瑞加、内野美樹、谷口紗織、村戸ドール、坪田一男
    • Organizer
      角膜カンファレンス2011
    • Place of Presentation
      東京
    • Year and Date
      2011-02-17
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] A Significant Role of Mesehchymal Stem Cells in Immune Processes and Pathogenic Fibrosis In Ocular Chronic Graft Versus Host Disease2011

    • Author(s)
      Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Yaguchi T, Inaba T, Kawakami Y, Okano H, Matsuzaki Y, Tsubota K.
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO), Annual Meeting, 2011
    • Place of Presentation
      Florida, USA.
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] Role of muscarinic acetylcholine receptors and Ca2+signaling in tear secretion2011

    • Author(s)
      Sasaki Y, Ogawa Y, Mikoshiba K, and Tsubota K
    • Organizer
      Association for Research in Vision and Ophthalmology(ARVO) Annual Meeting
    • Place of Presentation
      Fort Lauderdale, FL, USA
    • Data Source
      KAKENHI-PROJECT-22659312
  • [Presentation] Mucosal Microvilli In Dry Eye Patients With Chronic Graft-versus-host Disease2011

    • Author(s)
      Tatematsu Y, Ogawa Y, Shinmura S, Dogru M, Nagai T, Yaguchi S, Yamazaki K, Kameyama K, Kawakami Y, Tsubota K
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO), Annual meeting
    • Place of Presentation
      Florida, U.S.A.
    • Year and Date
      2011-05-03
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] A Significant Role of Mesehchymal Stem Cells in Immune Processes and Pathogenic Fibrosis In Ocular Chronic Graft Versus Host Disease2011

    • Author(s)
      Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Yaguchi T, Inaba T, Kawakami Y, Okano H, Matsuzaki Y, Tsubota K
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO), Annual meeting
    • Place of Presentation
      Florida, U.S.A.
    • Year and Date
      2011-05-04
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] Mucosal Microvilli In Dry Eye Patients With Chronic Graft-versus-host Disease2011

    • Author(s)
      Tatematsu Y, Ogawa Y, Shinmura S, Dogru M, Nagai T, Yaguchi S, Yamazaki K, Kameyama K, Kawakami Y, Tsubota K.
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO), Annual Meeting, 2011
    • Place of Presentation
      Florida, USA
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] ドナー間葉系幹細胞と慢性移植片対宿主病の発症機構/Donor mesenchymal stem cells trigger chronic graft-versus-host disease following minor antigen-mismatched bone marrow transplantation.2011

    • Author(s)
      Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Yaguchi T, Inaba T, Suzuki S, Yaguchi S, Kawakami Y, Okano H, Tsubota K, Matsuzaki Y.
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ国際会議場(千葉)
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] Aquaporin 1 Positive Mesenchymal Cell Imply Existence Of Cornea Limbal Niche Cells.2011

    • Author(s)
      Higa K, Kato N, Yoshida S, Ogawa Y, Shimazaki J, Tsubota K, Shimmura S.
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO), Annual Meeting, 2011
    • Place of Presentation
      Florida, USA
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] 慢性移植片対宿主病症例の涙腺における免疫担当細胞の局在とT細胞の活性化2011

    • Author(s)
      林勇海、小川葉子、榛村重人、川北哲也、谷口紗織、岡本真一郎、河上裕、坪田一男
    • Organizer
      慶應義塾大学医学部 第4学年 自主学習発表会
    • Place of Presentation
      慶應義塾大学医学部 北里講堂(東京)
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] Lacrimal Gland Inflammation And Fibrosis In Murine Model Of Ocular Graft Versus Host Disease2011

    • Author(s)
      Yaguchi S, Ogawa Y, Shinmura S, Tsubota K
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO), Annual meeting
    • Place of Presentation
      Florida, U.S.A.
    • Year and Date
      2011-05-03
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] 眼慢性移植片対宿主病におけるドナー由来線維芽細胞の細胞源の検討2011

    • Author(s)
      小川葉子,榛村重人,森川暁,馬渕洋,谷口智憲,鈴木禎史,河上裕,岡野英之,松崎有未,坪田一男
    • Organizer
      角膜カンファランス2011
    • Place of Presentation
      東京
    • Year and Date
      2011-02-18
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] Lacrimal Gland Inflammation And Fibrosis In Murine Model Of Ocular Graft Versus Host Disease.2011

    • Author(s)
      Yaguchi S, Ogawa Y, Shinmura S, Tsubota K.
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO), Annual Meeting, 2011
    • Place of Presentation
      Florida, USA
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] Role Of Intracellular Oxidative Stress In The Mechanism Of The Dry Eye Disease2011

    • Author(s)
      Uchino Y, Kawakita T, Miyazawa M, Ishii T, Onouchi H, Yasuda K, Ogawa Y, Shimmura S, Ishii N, Tsubota K.
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO), Annual Meeting, 2011
    • Place of Presentation
      Florida, USA
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] 眼慢性移植片対宿主病の発症機構におけるドナー間葉系幹細胞の役割2011

    • Author(s)
      小川葉子、榛村重人、森川 暁、馬渕 洋、谷口智憲、鈴木禎史、河上 裕、岡野英之、松崎有未、坪田一男
    • Organizer
      第115回日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Data Source
      KAKENHI-PROJECT-23592590
  • [Presentation] Role of muscarinic acetylcholine receptors and Ca2+ signaling in tear secretion2011

    • Author(s)
      稲葉隆明、坪田一男
    • Organizer
      ARVO annual meeting
    • Place of Presentation
      Fort Lauderdale, FK, USA
    • Data Source
      KAKENHI-PROJECT-22659312
  • [Presentation] A Radical Approach to Aging Eye Disease.2011

    • Author(s)
      Tsubota K.
    • Organizer
      Association for Research in Vision and Ophthalmology Annual meeting.
    • Place of Presentation
      Fort Lauderdale, FL,USA
    • Data Source
      KAKENHI-PROJECT-22390326
  • [Presentation] A semaphorin 3A inhibitor accelerates cornel reinnervation following penetrating keratoplasty on mice.2011

    • Author(s)
      M.Omoto, S.Shimmura, S Yoshida, T Kawakita, K.Tsubota
    • Organizer
      The Association for Research in Vision and Ophthalmology 2011 annual meeting
    • Place of Presentation
      アメリカ、フォートローダーデール
    • Year and Date
      2011-05-01
    • Data Source
      KAKENHI-PROJECT-21791712
  • [Presentation] Chronically disturbed IP_3 Receptor mediated Ca^<2+> signaling in exocrine glands causes Sjogren's syndrome-like autoimmune disease2010

    • Author(s)
      Ogawa Y, Akiyama T, Ebisui E, Ogawa N, MatsuiM, Takeuchi T, Mikoshiba K, Tsubota K
    • Organizer
      The 6th International Conference on the Tear Film & Ocular Surface Florence
    • Place of Presentation
      Italy
    • Data Source
      KAKENHI-PROJECT-22659312
  • [Presentation] Measurement of telomere length in lacrimal gland tissue sections using quantitative fluorescence in situ hybridization(Q-FISH)2010

    • Author(s)
      Kawashima M, Kawakita T, Maida Y, Kamoi M, Ogawa Y, Matsutomi K, Shimmura S, Tsubota K
    • Organizer
      ARVO2010
    • Place of Presentation
      Fort Lauderdale, FL, USA
    • Year and Date
      2010-05-05
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] Recovery of secretory function by clusterin derived from side population cells in exocrine glands2010

    • Author(s)
      Tsubota K
    • Organizer
      Association for Research in Vision and Ophthalmology(ARVO) Annual Meeting
    • Place of Presentation
      Fort Lauderdale, FL, USA
    • Data Source
      KAKENHI-PROJECT-22659312
  • [Presentation] Morohlogic evaluation of meibomian glands in chronic graft-versus-host disease.2010

    • Author(s)
      Ban Y, Ogawa Y, Ibrahim OMA, Tatematsu Y, Dogru M, Tsubota K.
    • Organizer
      6th International Conference on the Tear Film & Ocular Surface ; Basic Sience and Clinical Relevance.
    • Place of Presentation
      Florence, Italy
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] 眼慢性移殖片対宿主病における上皮間葉転換2010

    • Author(s)
      小川葉子、榛村重人、川北哲也、吉田悟、河上裕、坪田一男
    • Organizer
      第30回炎症再生医学会
    • Place of Presentation
      東京
    • Year and Date
      2010-08-05
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] Chronically distributed IP3 receptor-mediated Ca^<2+> Signaling in exocrine glands causes Sjogren's syndrome-like autoimmune disease.2010

    • Author(s)
      Inaba T, Hisatsune C, Sasaki Y, Ogawa Y, Mikoshiba K, Tsubota K
    • Organizer
      6^<th> International Conference on the Tear Film & Ocular Surface ; Basic Science and Clinical Relevance.
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] Donor fibroblast chimerism in animal model of ocular chronic graft versus host disease.2010

    • Author(s)
      Ogawa Y, Shimmura S, Morikawa S, Inaba T, Okano H, Matsuzaki Y, Tsubota K.
    • Organizer
      The Association of Research for Vision and Ophthalmology (ARVO) 2010.
    • Place of Presentation
      Fort Lauderdale, FL, USA
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] Keynote Adress ; The tearome : Not Just Hype : Anti-aging approach for the treatment of dry eye.2010

    • Author(s)
      Tsubota K, Kawashima M, Inaba T, Dogru M, Ogawa Y, Namamura S, Shinmura K, Higuchi A, Kawakita T.
    • Organizer
      6^<th> International Conference on the Tear Film & Ocular Surface ; Basic Science and Clinical Relevance.
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2010-09-23
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] Morohlogic evaluation of meibomian glands in chronic graft-versus-host-disease.2010

    • Author(s)
      Ban Y, Ogawa Y, Ibrahim OMA, Tatematsu Y, Dogru M, Tsubota K.
    • Organizer
      6^<th> International Conference on the Tear Film & Ocular Surface ; Basic Science and Clinical Relevance.
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2010-09-25
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] ヒト脈絡膜新生血管組織における上皮間葉系移行(EMT)関連転写因子の局在2010

    • Author(s)
      平沢学、野田航介、小沢洋子、小川葉子、鈴木美砂、坪田一男、石田晋
    • Organizer
      第114回日本眼科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-16
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] IP3R欠損マウスを用いたシェーグレン症候群の病態解明2010

    • Author(s)
      稲葉隆明、久恒智博、佐々木恭正、小川葉子、竹内勤、御子柴克彦、坪田一男
    • Organizer
      第19回シェーグレン症候群学会
    • Place of Presentation
      千葉
    • Year and Date
      2010-09-09
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] Anti-Aging Approach for the Treatment of Dry Eye.2010

    • Author(s)
      坪田一男
    • Organizer
      The 2nd Asia Cornea Society Biennial Scientific Meeting.
    • Place of Presentation
      京都、日本
    • Data Source
      KAKENHI-PROJECT-22390326
  • [Presentation] Chronically distributed IP_3 receptor-mediated Ca^<2+> Signaling in exocrine glands causes Sjogren's syndrome-like autoimmune disease.2010

    • Author(s)
      稲葉隆明、坪田一男
    • Organizer
      6th International Conference on the Tear Film & Ocular Surface
    • Place of Presentation
      Florence, Italy
    • Data Source
      KAKENHI-PROJECT-22659312
  • [Presentation] Characterization of Meibomian Gland in Patients with Chronic Graft-Versus-Host Disease Related Dry Eye Using in vivo Laser Confocal Microscopy2010

    • Author(s)
      Ban Y, Ogawa Y, Ibrahim, MA.O, Tatematsu Y, Dogru M, Tsubota K
    • Organizer
      The 21^<nd> Asia Cornea Society Biennial Scientific Meeting
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-12-02
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] Recovery of secretory function by clusterin derived from side population cells in exocrine glands2010

    • Author(s)
      坪田一男
    • Organizer
      ARVO Annual Meeting
    • Place of Presentation
      Fort Lauderdale, FL, USA
    • Data Source
      KAKENHI-PROJECT-22659312
  • [Presentation] Bone marrow mesenchymal stem cells trigger pathogenic fibrosis in chronic graft-versus-host-disease.2010

    • Author(s)
      Ogawa Y, Shimmura Y, Morikawa S, Mabuchi Y, Inaba T, Okano H, Matsuzaki Y, Tsubota K
    • Organizer
      6th International Conference on the Tear Film & Ocular Surface ; Basic Sience and Clinical Relevance.
    • Place of Presentation
      Florence, Italy
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] Anti-Aging Approach for the Treatment of Dry Eye.2010

    • Author(s)
      Tsubota K.
    • Organizer
      The 2nd Asia Cornea Society Biennial Scientific Meeting.
    • Place of Presentation
      kyoto, Japan
    • Data Source
      KAKENHI-PROJECT-22390326
  • [Presentation] Donor fibroblast chimerism in animal model of ocular chronic graft versus host disease2010

    • Author(s)
      Ogawa,Y, Shimmura S, Morikawa S, Inaba T, Okano H, Matsuzaki Y, Tsubota K.
    • Organizer
      ARVO2010
    • Place of Presentation
      Fort Lauderdale, FL, USA
    • Year and Date
      2010-05-05
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] Lacrimal Punctal Cauterization in the Management of Ocular Chronic Graft-Versus-Host Disease2010

    • Author(s)
      Yaguchi S, Ogawa Y, Kamoi M, Uchino M, Tatematsu Y, Ban Y, Ohba E, Goto E, Tsubota K
    • Organizer
      The 2^<nd> Asia Cornea Society Biennial Scientific Meeting
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-12-02
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] Bone marrow mesenchymal stem cells trigger pathogenic fibrosis in chronic graft-versus-host-disease.2010

    • Author(s)
      Ogawa Y, Shimmura Y, Morikawa S, Mabuchi Y, Inaba T, Okano H, Matsuzaki Y, Tsubota K
    • Organizer
      6^<th> International Conference on the Tear Film & Ocular Surface ; Basic Science and Clinical Relevance.
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] シェーグレン症候群眼表面における最新の画像診断技術2010

    • Author(s)
      村戸ドール、松本幸裕、若松タイスヒトミ、佐藤エンリケアダン、オサマモハメドアリイブラヒム、小島隆司、海道美奈子、石田玲子、小川葉子、小畑博人、坪田一男
    • Organizer
      第15回シェーグレン症候群セミナー
    • Place of Presentation
      東京
    • Year and Date
      2010-05-22
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] Matrix metalloproteinase(MMP9)is expressed during corneal perforation in chronic graft-versus-host disease2010

    • Author(s)
      Inagaki E, Ogawa Y, Matsumoto Y, Kawakita T, Shimmura S, Tsubota K
    • Organizer
      ARVO2010
    • Place of Presentation
      Fort Lauderdale, FL, USA
    • Year and Date
      2010-05-02
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] Role of Inositol 1,4,5,-Triphosphate Receptors and Ca^<2+> Signaling in Tear Secretion2010

    • Author(s)
      Inaba T, Hisatsune C, Sasaki Y, Ogawa Y, Mikoshiba K, Tsubota K
    • Organizer
      ARVO2010
    • Place of Presentation
      Fort Lauderdale, FL, USA
    • Year and Date
      2010-05-05
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] Localization of transcriptional factors associated with epithelial-mesenchymal transition in choroidal neovascularization2010

    • Author(s)
      Hirasawa M, Noda K, Suzuki M, Ogawa Y, Ozawa Y, Tsubota K
    • Organizer
      ARVO2010
    • Place of Presentation
      Fort Lauderdale, FL, USA
    • Year and Date
      2010-05-06
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] Bone marrow mesenchymal stem cells trigger pathogenic fibrosis in chronic graft-versus-host-disease.2010

    • Author(s)
      Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Inaba T, Okano H, Matsuzaki Y, Tsubota K.
    • Organizer
      Gordon Conference. 1^<st> Biology & Pathobiology of the Cornea.
    • Place of Presentation
      Ventura, CA, USA.
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] 眼慢性移殖片対宿主病における上皮間葉転換2010

    • Author(s)
      小川葉子、榛村重人、川北哲也、吉田悟、河上裕、坪田一男
    • Organizer
      第30回日本炎症再生医学会
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] イノシトール1、4、5三リン酸受容体欠損マウスの涙液分泌と角膜上皮障害2009

    • Author(s)
      稲葉隆明, 佐々木恭正, 久恒智博, 小川葉子, 御子柴克彦, 坪田一男
    • Organizer
      第33回角膜カンファランス
    • Place of Presentation
      大阪
    • Year and Date
      2009-02-20
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] Mikulictz病を疑った4例の血清IgG4値、涙腺生検所見、治療経過の比較検討2009

    • Author(s)
      平山雅敏, 羽藤晋, 小川葉子, 亀山香織, 海道美奈子, 石田玲子, 榛村重人, 坪田一男
    • Organizer
      第33回角膜カンフアランス
    • Place of Presentation
      大阪
    • Year and Date
      2009-02-20
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] Analysis of pathogenic fibrosis in animal model of ocular chronic graft versus host disease2009

    • Author(s)
      Ogawa Y, Shimmura S, Inaba T, Okano H, Kawakami Y, Tsubota K.
    • Organizer
      The 9th WCI : World Congress on Inflammation
    • Place of Presentation
      Tokyo
    • Year and Date
      2009-07-07
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] ドライアイ旧診断基準と新診断基準の比較2009

    • Author(s)
      内野美樹, 村戸ドール, 内野裕一, サマンサワード, 若松タイスヒトミ, オサマイブラヒム, 小川葉子, 横井則彦, 坪田一男
    • Organizer
      第33回角膜カンファランス
    • Place of Presentation
      大阪
    • Year and Date
      2009-02-20
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] ヒト骨髄間葉系幹細胞のフィーダー細胞としての有用性2009

    • Author(s)
      大本雅弘・宮下英之・比嘉一成・坪田一男・榛村重人
    • Organizer
      第8回日本再生医療学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-06
    • Data Source
      KAKENHI-PROJECT-19791292
  • [Presentation] マウス涙腺慢性移植片対宿主病モデルにおける病的線維化の発症と進展機序の解析2009

    • Author(s)
      小川葉子,榛村重人,稲葉隆明,河上裕,岡野栄之,坪田一男
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-16
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] 角膜輪部上皮未分化細胞の維持とN-cadherinの関係2009

    • Author(s)
      比嘉一成, 榛村重人, 加藤直子, 宮下英之, 小川葉子, 川北哲也, 島崎潤, 坪田一男
    • Organizer
      第33回角膜カンファランス
    • Place of Presentation
      大阪
    • Year and Date
      2009-02-19
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] 抗癌剤TS-1^Rによる閉塞性マイボーム腺機能不全2009

    • Author(s)
      松本幸裕, 村戸ドール, 佐藤エンリケアダン, オサマイブラヒム, 立松由佳子, 小川葉子, 榛村重人, 坪田一男
    • Organizer
      第33回角膜カンファランス
    • Place of Presentation
      大阪
    • Year and Date
      2009-02-20
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] マウス慢性移植片対宿主病における線維化病変の検討2009

    • Author(s)
      小川葉子,榛村重人,森川暁,鈴木禎史,稲葉隆明,河上裕,岡野栄之,松崎有未,坪田一男
    • Organizer
      第8回日本再生医療学会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-06
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] Analysis of pathogenic fibrosis in animal model of ocular chornic graft versus host disease.2009

    • Author(s)
      Ogawa Y, Shimmura S, Inaba T, Okano H, Kawakami Y, Tsubota K.
    • Organizer
      The 9^<th> world congress of inflammation.
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2009-07-07
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] カロリー制限による加齢性涙液分泌能低下の抑制2009

    • Author(s)
      川島素子, 川北哲也, 岡田直子, 小林真也, 小川葉子, 村戸ドール, 榛村重人, 新村健, 坪田一男
    • Organizer
      第33回角膜カンファランス
    • Place of Presentation
      大阪
    • Year and Date
      2009-02-20
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] マウス涙腺慢性移植片対宿主病モデルにおける病的線維化の発症と進展機序の解析2009

    • Author(s)
      小川葉子, 榛村重人, 稲葉隆明, 河上裕, 岡野栄之, 坪田一男
    • Organizer
      第113回日本眼科学会総会, 東京
    • Place of Presentation
      東京
    • Year and Date
      2009-04-16
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] The Use of Human Mesenchymal Stem Cells as Feeder Cells in Cultivated Corneal Epithelial Sheets2008

    • Author(s)
      M. Omoto, H. Miyashita, K. Higa, K. Tsubota, S. Shimmura
    • Organizer
      The Association for Research in Vision and Ophthalmology 2008 annual meeting
    • Place of Presentation
      アメリカ、フォートローダーデール
    • Year and Date
      2008-05-01
    • Data Source
      KAKENHI-PROJECT-19791292
  • [Presentation] Epithelial-Mesenchymal Transition of Conjunctival Basal Epithelia in Human Chronic Graft versus Host Disease.2008

    • Author(s)
      Ogawa Y, Shimmura S, Kawakita T, Okano H, Kawakami K, Tsubota K.
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO2008), Annual meeting
    • Place of Presentation
      Florida, USA.
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] 慢性移植片対宿主病の結膜上皮における上皮間葉系移行2008

    • Author(s)
      小川葉子,榛村重人,川北哲也,河上裕,岡野栄之,坪田一男
    • Organizer
      第32回角膜カンファランス
    • Place of Presentation
      東京
    • Year and Date
      2008-02-28
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] Corneal Wound Healing Following Penetrating Keratoplasty on Mice2007

    • Author(s)
      M. Omoto, S. Shimmura, S. Yoshida, H. Miyashita, K. Tsubota
    • Organizer
      The Association for Research in Vision and Ophthalmology 2007 annual meeting
    • Place of Presentation
      アメリカ、フォートローダーデール
    • Year and Date
      2007-05-08
    • Data Source
      KAKENHI-PROJECT-19791292
  • [Presentation] Comparison of 3 Measurement Scales for Grading Ocular Chronic Graft-Versus-Host Disease Patients

    • Author(s)
      Tatematsu Y, Ogawa Y, Abe T, Kamoi M, Uchino M, Saijyo-Ban Y, Yaguchi S, Mori T, Okamoto S, Tsubota K.
    • Organizer
      World Ophthalmology Congress of the International Council of Ophthalmology (WOC2014)
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2014-04-02 – 2014-04-06
    • Data Source
      KAKENHI-PROJECT-26462668
  • [Presentation] 糖尿病モデルマウスを用いたSIRT1を介する涙腺機能の変化

    • Author(s)
      稲葉隆明、田中康久、渡辺光博、新村健、坪田一男
    • Organizer
      第15回日本抗加齢医学会総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2015-05-29 – 2015-05-31
    • Data Source
      KAKENHI-PROJECT-25670737
  • [Presentation] Epithelial mesenchymal transition in human ocular chronic graft-versus-host disease.

    • Author(s)
      Ogawa Y, Shimmura S, Kawakita T, Yoshida S, Kawakami Y, Tsubota K.
    • Organizer
      第6回ドライアイリ サーチアワード受賞講演(Am J Pathol. 2009;175(6):2372-2381.オキュラ-サーフェス専門別研究会 第64回日本臨床眼科学会 神戸平成22年11月12-15日)
    • Data Source
      KAKENHI-PROJECT-20592058
  • [Presentation] The Bioengineered Lacrimal Gland Using Cells Derived from Different Transgenic Mice: as a Novel Experimental Model for a Lacrimal Gland Biological Analysis.

    • Author(s)
      Hirayama M, Kawakita T, Shimmura S, Tsuji T, Tsubota K
    • Organizer
      Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      2015-05-05 – 2015-05-08
    • Invited
    • Data Source
      KAKENHI-PROJECT-25242041
  • [Presentation] Macrophage expressing oxidative stress marker play some role in lacrimal gland of chronic graft-versus-host disease

    • Author(s)
      Ogawa Y, Shimmura S, Suzuki T, Kawai M, Tsubota K.
    • Organizer
      The Annual Meeting of Association for Research in Vision and Ophthalmology 2014 (ARVO2014)
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2014-05-02 – 2014-05-06
    • Data Source
      KAKENHI-PROJECT-26462668
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