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HASHIMOTO Shuichi  橋本 修一

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… Alternative Names

橋本 修一  ハシモト シュウイチ

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Researcher Number 00243931
Affiliation (based on the past Project Information) *help 2018 – 2021: 福岡歯科大学, 口腔歯学部, 教授
2016: 福岡歯科大学, 口腔歯学部, 教授
2014 – 2015: 福岡歯科大学, 歯学部, 教授
2013: 熊本大学, 大学院生命科学研究部(医), 准教授
2012: 熊本大学, 大学院生命科学研究部機能病理学分野, 准教授 … More
2011: 熊本大学, 生命科学研究部, 准教授
2004: 九大, 医学(系)研究科(研究院), 助手
2002 – 2003: 九州大学, 大学院・医学研究院, 助手
2000: 九大, 医学(系)研究科, 助手
1999: Kyushu University, Graduate School of Medicine, Assistant, 大学院・医学系研究科, 助手
1998: 九州大学, 医学部, 助手
1993 – 1996: 九州大学, 医学部, 助手
1987: 九州大学, 医学部, 医員 Less
Review Section/Research Field
Principal Investigator
Human pathology / Human pathology / Experimental pathology / Respiratory organ internal medicine / Basic Section 49020:Human pathology-related / Basic Section 57020:Oral pathobiological science-related
Except Principal Investigator
Human pathology / Experimental pathology / Human pathology
Keywords
Principal Investigator
CC10 / SP-A / 肺腺癌 / beta-catenin / N-Nitrosodiethylamine (DEN) / Piperonylbutoxide (PIP) / Lung tumor / PCNA / RAT / proSP-C … More / p53 / クララ細胞 / SP-B / 発生母細胞 / 免疫組織化学 / 予後因子 / Lung / Cancer / Epithelium / Differentiation / Stem Cell / Sox2 / p63 / Sox9 / Notch / Stem cell / Airway epithelium / 肺癌 / 幹細胞 / Lgr6 / R-spondin / Wnt / N-nitrosodiethylamine / 肺腫瘍 / ラット / サーファクタント・アポ蛋白 / 異型腺腫様過形成(AAH) / Ki-67(MIB-1) / マイクロディセクション / レーザーマイクロディセクション / Lung Cancer / Atypical Adenomatous Hyperplasia (AAH) / Ki-67 (MIB-1) / Microdissection / PKM2 / TGIF2 / EMT / Warburg effect / 口腔上皮性異型性 / 口腔扁平上皮癌 / 口腔上皮性異形成 / Oral SCC / Oral cancer / Immunologic dormancy / Cancer stemness / IDO1 / Kynurenine … More
Except Principal Investigator
遺伝子治療 / 血管新生 / VEGF / 遺伝子導入 / p53 / 血管リモデリング / 血管内皮細胞 / Endothelial Cell / Gene Transfer / Angiogenesis / 肺腺がん / 動脈硬化 / NO / atherosclerosis / angiogenesis / Sev / FGF-2 / MCP-1 / 血栓症 / 転写因子 / Gene Therapy / Vascular Remodeling / HVJ-catinic liposome / HVJ-liposome / 血管 / 肝 / 導入効率 / EP-24.16 / 肺腺癌 / 肺扁平上皮癌 / エンドペプチダーゼ / 転移 / マイクロディセクション / 肺線がん / 肺異型腺腫様過形成 / PCR-SSCP / 末梢型肺腺がん / MMP / TIMP-2 / 浸潤能 / プロテオミクス / 基質膜抗原 / 病理標本 / プロテオーム解析 / 遺伝子解析 / 発癌 / 異型線腫様過形成 / II型肺胞上皮細胞 / 培養肺腫瘍細胞 / HVJ・liposome法 / アポトーシス / gene therapy / HVJ-lipsome method / apoptosis / 遺伝子導入ベクター / Sevベクター / PTCA / TGFβ^1 / 血管新生病 / デコイオリゴ / gene transfer vector / vascular remodeling / 一酸化窒素 / アンチセンス / リポソーム / デコイ / Antisense / Liposome / Transcription Factor / Decoy / シグナル伝達 / cross-talk sianal Less
  • Research Projects

    (19 results)
  • Research Products

    (17 results)
  • Co-Researchers

    (25 People)
  •  Clarification of the immune mechanism for the entry of oral carcinomas into dormancyPrincipal Investigator

    • Principal Investigator
      橋本 修一
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57020:Oral pathobiological science-related
    • Research Institution
      Fukuoka Dental College
  •  口腔悪性腫瘍におけるPKM2の機能および関連因子間制御機構の解明Principal Investigator

    • Principal Investigator
      橋本 修一
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      Fukuoka Dental College
  •  Expression and functional analyses of R-spondin-Lgr6 signaling pathway in lung cancerPrincipal Investigator

    • Principal Investigator
      Hashimoto Shuichi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      Fukuoka Dental College
  •  Analysis of beta-Catenin/Sox2/p63 Signal Pathway in Lung Epithelial Differentiation and TumorigenesisPrincipal Investigator

    • Principal Investigator
      HASHIMOTO Shuichi
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Kumamoto University
  •  肺癌におけるFGFs、FGFRsおよびSproutysの発現・機能解析Principal Investigator

    • Principal Investigator
      橋本 修一
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      Kyushu University
  •  病理標本におけるタンパク質発現動態からの分子病態解析の試み

    • Principal Investigator
      居石 克夫
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Human pathology
    • Research Institution
      Kyushu University
  •  Moleculo-Pathological studies on intracellular cross-talk signal in angiogenic process.

    • Principal Investigator
      NAKAGAWA Kazunori
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      KYUSHU UNIVERSITY
  •  ヒト肺腺癌と前癌病変(AAH)における発癌関与遺伝子のDNAマイクロアレイ解析Principal Investigator

    • Principal Investigator
      橋本 修一
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Human pathology
    • Research Institution
      Kyushu University
  •  ディファレンシャルディスプレイを利用した病理標本の分子病態学的研究

    • Principal Investigator
      居石 克夫
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Human pathology
    • Research Institution
      Kyushu University
  •  Patho-physiological studies on cellular interaction in vascular injury and vascular remodeling

    • Principal Investigator
      NAKAGAWA Kazunori
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      KYUSHU UNIVERSITY
  •  Trial research for practical use of the reagent for gene expression control by Decoy oligo nucleotide.

    • Principal Investigator
      NAKAGAWA Kazunori
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Experimental pathology
    • Research Institution
      KYUSHU UNIVERSITY
  •  腫瘍増殖におけるメタロエンドペプチダーゼEP-24.16の分子病態学的解析

    • Principal Investigator
      中川 和憲
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Human pathology
    • Research Institution
      Kyushu University
  •  Molecular pathobiological Study on Endothelial Function Ocurring during Vascular Remodeling

    • Principal Investigator
      SUEISHI Katsuo
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (A).
    • Research Field
      Human pathology
    • Research Institution
      KYUSHU UNIVERSITY
  •  Gene Abberation Analysis in Precancerous Lesion of the Lung Adenocarcinoma by Laser Microdissection SystemPrincipal Investigator

    • Principal Investigator
      HASHIMOTO Shuichi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      Kyushu University
  •  遺伝子導入ベクターの開発とin vivo応用

    • Principal Investigator
      SUEISHI Katsuo
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Human pathology
    • Research Institution
      Kyushu University
  •  Endothelial Modulation of Vascular Remodeling

    • Principal Investigator
      SUEISHI Katsuo
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Human pathology
    • Research Institution
      Kyushu University
  •  Histogenesis of Rat Lung Tumors induced by N-Nitrosodiethylamine (DEN)Principal Investigator

    • Principal Investigator
      HASHIMOTO Shuichi
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Kyushu University
  •  末梢性肺腺癌の発生病理ならびに組織亜型分類に関する分子病理学的研究Principal Investigator

    • Principal Investigator
      橋本 修一
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Human pathology
    • Research Institution
      Kyushu University
  •  肺癌発生における環境要因に関する日米中国の比較研究

    • Principal Investigator
      重松 信昭
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Overseas Scientific Research
    • Research Institution
      Kyushu University

All 2021 2020 2019 2018 2016 2013 2003

All Journal Article Presentation

  • [Journal Article] NFAT5 promotes oral squamous cell carcinoma progression in hyper-osmotic environment2021

    • Author(s)
      Yoshimoto Shohei、Morita Hiromitsu、Matsuda Miho、Katakura Yoshinori、Hirata Masato、Hashimoto Shuichi
    • Journal Title

      Laboratory Investigation

      Volume: 101 Pages: 38-50

    • DOI

      10.1038/s41374-020-00486-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07033, KAKENHI-PROJECT-20K18490, KAKENHI-PROJECT-20H03854, KAKENHI-PROJECT-17K11645, KAKENHI-PROJECT-17K19766, KAKENHI-PROJECT-17K18301
  • [Journal Article] Inhibition of Alk signaling promotes the induction of human salivary-gland-derived organoids2020

    • Author(s)
      Yoshimoto Shohei、Yoshizumi Junko、Anzai Hiromasa、Morishita Koichiro、Okamura Kazuhiko、Hiraki Akimitsu、Hashimoto Shuichi
    • Journal Title

      Disease Models & Mechanisms

      Volume: 13 Pages: 1-9

    • DOI

      10.1242/dmm.045054

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07033, KAKENHI-PROJECT-20K10129, KAKENHI-PROJECT-20K18490, KAKENHI-PROJECT-17K18301
  • [Journal Article] Hypoxia-induced HIF-1α and ZEB1 are critical for the malignant transformation of ameloblastoma via TGF-β-dependent EMT.2019

    • Author(s)
      Shohei Yoshimoto, Fumie Tanaka, Hiromitsu Morita, Akimitsu Hiraki, Shuichi Hashimoto
    • Journal Title

      Cancer Medicine

      Volume: 8 Pages: 7822-7832

    • DOI

      10.1002/cam4.2667

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07033, KAKENHI-PROJECT-17K18301, KAKENHI-PROJECT-16K11713
  • [Journal Article] Nuclear PKM2 promotes the progression of oral squamous cell carcinoma by inducing EMT and post-translationally repressing TGIF2.2018

    • Author(s)
      Tanaka Fumie、Yoshimoto Shohei、Okamura Kazuhiko、Ikebe Tetsuro、Hashimoto Shuichi
    • Journal Title

      oncotarget

      Volume: 9 Pages: 33745-33761

    • DOI

      10.18632/oncotarget.25850

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07033, KAKENHI-PROJECT-17K18301
  • [Journal Article] 免疫組織化学的染色法2013

    • Author(s)
      橋本 修一、中川 和憲、Barry R. Stripp
    • Journal Title

      呼吸

      Volume: 32 Pages: 1162-1175

    • Data Source
      KAKENHI-PROJECT-23590466
  • [Journal Article] 免疫組織化学的染色法;講座研究手法入門:生化学的・免疫学的実験法2013

    • Author(s)
      橋本修一、中川和憲、Barry R Stripp
    • Journal Title

      呼吸

      Volume: 32巻12号 Pages: 1162-1175

    • Data Source
      KAKENHI-PROJECT-23590466
  • [Journal Article] 発達肺および傷害再生肺における肺上皮分化制御機構-肺幹細胞生物学の進歩と肺再生医療への礎–日本肺サーファクタント2013

    • Author(s)
      橋本修一
    • Journal Title

      界面医学会雑誌

      Volume: 44巻 Pages: 2-15

    • Data Source
      KAKENHI-PROJECT-23590466
  • [Journal Article] 発達肺および傷害再生肺における肺上皮分化制御機構 - 肺幹細胞生物学の進歩と肺再生医療への礎 -2013

    • Author(s)
      橋本 修一
    • Journal Title

      日本肺サーファクタント・界面医学会雑誌

      Volume: 44 Pages: 2-15

    • Data Source
      KAKENHI-PROJECT-23590466
  • [Journal Article] Recombinant Sendai virus vectors for activated T lymphocytes.2003

    • Author(s)
      Okano S, Yonemitsu Y, Nagata S, Sata S, Onimaru M, Nakagawa K, Tomita Y, Kishihara K, Hashimoto S, Nakashima Y, Sugimachi K, Hasegawa M, Sueishi K
    • Journal Title

      Gene Ther 10(16)

      Pages: 1381-1391

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370078
  • [Presentation] NFAT5 enhances the oral squamous cell carcinoma progression in the hyper-osmotic condition through the EGFR activation2020

    • Author(s)
      Shohei Yoshimoto, Shuichi Hashimoto
    • Organizer
      第79回日本癌学会
    • Data Source
      KAKENHI-PROJECT-18K07033
  • [Presentation] HIF‐1α and ZEB1 are critical for the malignant transformation of ameloblastoma2020

    • Author(s)
      Shohei Yoshimoto, Fumie Tanaka, Hiromitsu Morita, Akimitsu Hiraki, Shuichi Hashimoto
    • Organizer
      第109回日本病理学会
    • Data Source
      KAKENHI-PROJECT-18K07033
  • [Presentation] IFN-γ-triggered triptophan-IDO1-kynurenine-AhR signal activation induces immunologic tumor dormancy in OSCC2020

    • Author(s)
      Hiromasa Anzai, Shohei Yoshimoto, Kenichiro Hashimoto, Akimitsu Hiraki, Shuichi Hashimoto
    • Organizer
      第79回日本癌学会
    • Data Source
      KAKENHI-PROJECT-18K07033
  • [Presentation] IFN-γ-triggered triptophan-IDO1-kynurenine-AhR signal activation induces immunologic tumor dormancy in human oral squamous cell carcinomas2020

    • Author(s)
      Hiromasa Anzai, Shohei Yoshimoto, Akimitsu Hiraki, Shuichi Hashimoto
    • Organizer
      第62回歯科基礎医学会学術大会
    • Data Source
      KAKENHI-PROJECT-18K07033
  • [Presentation] Nuclear PKM2 promotes the progression of oral squamous cell carcinoma by inducing EMT2019

    • Author(s)
      吉本尚平、田中文恵、岡村和彦、池邉哲郎、橋本修一
    • Organizer
      第108回 日本病理学会
    • Data Source
      KAKENHI-PROJECT-18K07033
  • [Presentation] Nuclear PKM2 promotes the progression of oral squamous cell carcinoma by inducing EMT2019

    • Author(s)
      Fumie Tanaka1, Shohei Yoshimoto, Kazuhiko Okamura, Tetsuro Ikebe, Shuichi Hashimoto
    • Organizer
      第108回日本病理学会
    • Data Source
      KAKENHI-PROJECT-18K07033
  • [Presentation] Hypoxia induced HIF-1α and ZEB1 are critical for the malignant transformation of ameloblastoma2019

    • Author(s)
      吉本尚平, 森田浩光, 橋本修一
    • Organizer
      第61回歯科基礎医学会
    • Data Source
      KAKENHI-PROJECT-18K07033
  • [Presentation] Stem Cell Marker Lgr6 Expression Analysis in Lung and Oral Cancers2016

    • Author(s)
      橋本修一, 白羽英則, 高山浩一, 中川和憲, 中西洋一
    • Organizer
      第23回日本歯科医学会総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2016-10-21
    • Data Source
      KAKENHI-PROJECT-26460436
  • 1.  SUEISHI Katsuo (70108710)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 1 results
  • 2.  NAKAGAWA Kazunori (50217668)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 2 results
  • 3.  NAKASHIMA Yutaka (50135349)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 1 results
  • 4.  KONO Shinji (20225379)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  TASHIRO Yoshihiko (10188237)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  YONEMITSU Yoshikazu (40315065)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 7.  ISHIBASHI Hiroaki (90254630)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  ITO Takaaki (70168392)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  NAKANISHI Yoichi (20172356)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 10.  TAKAYAMA Koichi (50274444)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 11.  SHIRAHA Hidenori (40379748)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 12.  HARA Nobuyuki (90038802)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  SAKAMOTO Taiji (10235179)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  重松 信昭 (40038683)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  信友 浩一 (90037424)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  光山 孝志 (00253419)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  矢川 克郎 (90183665)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  広畑 富雄 (50102075)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  STEVEN Piant
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  冨安 幸博
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  HIRAKI Akimitsu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  吉本 尚平
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 23.  平田 雅人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 24.  松田 美穂
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  森田 浩光
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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