GODA Nobuhito 合田亘人

… Alternative Names

合田亘人ゴウダノブヒト

合田宣人ゴウダノブヒト

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Researcher Number	00245549
Other IDs	https://orcid.org/0000-0003-0295-4257
Affiliation (Current)	2025: 早稲田大学, 理工学術院, 教授
Affiliation (based on the past Project Information) *help	2009 – 2023: 早稲田大学, 理工学術院, 教授 2004 – 2006: Keio University, School of Medicine, Associate Professor, 医学部, 講師 2002 – 2004: 慶應義塾大学, 医学部, 専任講師
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Pathological medical chemistry / Functional biochemistry Except Principal Investigator General surgery / Pathological medical chemistry / Biological Sciences / General anatomy (including histology/embryology) / Pediatrics / Biomedical engineering/Biological material science
Keywords	Principal Investigator 糖尿病 / ヘパトカイン / 肝臓 / ニューレグリン1 / HIF-1 / 糖代謝 / 低酸素応答 / 臓器間クロストーク / 血糖調節 / ErbB3受容体 … More / 代償性膵島肥大 / 2型糖尿病 / 分泌因子 / 膵B細胞 / 細胞分化 / 分化 / 膵b細胞 / colitis / hypoxic stress / acetaminophen / T lymphocytes / inflammation / cytokines / 転写発現制御 / リンパ球分化・発達 / 粘膜免疫 / 遺伝子改変 / 腸炎 / 低酸素ストレス / アセトアミノフェン / T細胞 / 炎症 / サイトカイン / 肝線維化 / lipin-1 / ペルオキシゾーム / 低酸素 / HIF / 脂肪肝 / 脂質代謝 … More Except Principal Investigator knockout mice / soluble guanylate cyclase / hypoxia / nitric oxide / heme oxygenase / ノックアウト動物 / 一酸化炭素 / 低酸素 / 低酸素応答 / hypoxia inducible factor-1 / cell cycle / cyclin / liver regeneration / ischemia / 部分肝切除術 / ノックアウトマウス / HIF-1 / 細胞周期 / サイクリン / 肝再生 / 虚血 / cystathionine β-synthase / carbon monoixde / cystathionine beta synthase / conditional knock out mice / carbon monoxide / heme oxgenase / microcirculation / 胆汁分泌 / cystathionine β synthase / アミノ酸置換体 / 硫化水素 / シスタチオニン合成酵素 / シスタチオニンベータシンターゼ / 遺伝子改変動物 / 一酸化窒素 / 可溶性グアニル酸シクラーゼ / ヘムオキシゲナーゼ / isolated lymphoid follicles / cryptopatch / secretory IgA antibody / intestinal T cells / γδ T cells / intestinal flora / immunology / dietary substances / Heme oxygenase / インターロイキン15 / 樹状細胞 / 腸管上皮細胞 / 腸内常在フローラ / 分泌型lgA抗体 / 腸管孤立リンパ小節 / トランスレーショナルリサーチ / 生体分子 / 腸管上皮細胞間T細胞 / 炎症性腸疾患 / 経口免疫寛容 / 孤立リンパ小節 / クリプトパッチ / 分泌型IgA抗体 / 腸管上皮細胞T細胞 / γδT細胞 / 腸内フローラ / 免疫学 / 食品 / 低酸素シグナル / ストレス / 内科 / HIF / 低酸素センサー / エネルギー / 線維化 / 炎症 / 心臓病 / 肝臓病 / 慢性腎臓病 / 生活習慣病 / ミトコンドリア / ミトコンドリア代謝 / 脂質代謝 / 糖代謝 / 巨核球 / 細胞分化 / 遺伝子発現 / 血管内皮細胞 / 酸化ストレス / 血管リモデリング / 未熟児 / 先天性心疾患 / 酸素化 / プロスタグランジン / 弾性線維 / 新生児 / 動脈管 / vascular remodeling / 熱傷 / 消化管穿孔性腹膜炎 / 交互積層膜 / ナノシート / バイオマテリアル / 医用材料 / 創傷被覆材 / 高分子超薄膜 Less

糖尿病における膵B細胞の分化変容に対する新規ヘパトカインの病態機能解析Principal Investigator
- Principal Investigator
  
  合田亘人
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Waseda University
Novel mechanism of blood glucose regulation based on inter-organ crosstalk mediated by liver-derived proteins.Principal Investigator
- Principal Investigator
  
  GODA NOBUHITO
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Waseda University
Research on pathological role of a novel hepatokine, neuregulin 1, in diabetes mellitusPrincipal Investigator
- Principal Investigator
  
  Goda Nobuhito
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Waseda University
;The roles of hypoxia signaling in the pathogenesis of lifestyle related diseases
- Principal Investigator
  
  Nangaku Masaomi
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
The regulation of in vitro megakaryocyte differentiation and platelet production by hypoxia
- Principal Investigator
  
  KANAI MAI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General anatomy (including histology/embryology)
- Research Institution
  Waseda University
Molecular mechanisms of ductus arteriosus closure
- Principal Investigator
  
  MINAMISAWA Susumu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
  Waseda University
Analysis of pathological roles of hypoxic responses in the regulation of organ metabolism in fatty liver diseasesPrincipal Investigator
- Principal Investigator
  
  GODA Nobuhito
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Waseda University
Development of functional polymer nanosheet for the treatment of burn injury and gastrointestinal tissue defects.
- Principal Investigator
  
  TAKEOKA Shinji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Waseda University
Role of HIF-1 in the regulation of inflammatory responses through sensing alterations in microenvironments of immune cellsPrincipal Investigator
- Principal Investigator
  
  GODA Nobuhito
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Keio University
Role of hypoxia inducible factor-1α in the regulation of hypoxic responses in liver.
- Principal Investigator
  
  SHIMAZU Motohide
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Keio University
Analysis of molecular mechanisms by which heme oxygenase-carbon monoxide pathway regulates cellular functions under physiological and pathophysiological conditions using newly developed gene targeting mice.
- Principal Investigator
  
  SUEMATSU Makoto
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Keio University
Investigation of immuno-regulatory competency of dietary substances and its application for our own beneficial ends
- Principal Investigator
  
  ISHIKAWA Hiromichi
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  Keio University

[Book] 細胞2013
- Author(s)
  合田　亘人
- Publisher
  ニュー・サイエンス社
- Data Source
  KAKENHI-PROJECT-23590370
[Book] 医学のあゆみ2013
- Author(s)
  合田　亘人、加藤　早由華
- Publisher
  医師薬出版株式会社
- Data Source
  KAKENHI-PROJECT-23590370
[Book] 医学のあゆみ244(4)2013
- Author(s)
  合田亘人, 加藤早由華
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-23590370
[Book] HIFを介した防御機構：低酸素ストレス下のエネルギー代謝制御2012
- Author(s)
  合田　亘人、加藤　早由華
- Publisher
  医歯薬出版株式会社医学のあゆみ
- Data Source
  KAKENHI-PROJECT-23590370
[Book] 低酸素シグナリング　-HIFシグナリング-2012
- Author(s)
  合田　亘人、金井　麻衣
- Publisher
  羊土社　イラストで徹底理解するシグナル伝達キーワード事典
- Data Source
  KAKENHI-PROJECT-23590370
[Book] HIFが制御するエネルギー代謝2012
- Author(s)
  合田　亘人、鈴木　智大、金井　麻衣
- Publisher
  羊土社　実験医学
- Data Source
  KAKENHI-PROJECT-23590370
[Book] 肝疾患とHIFを介した低酸素応答2012
- Author(s)
  合田　亘人、長内　康太
- Publisher
  メディカルレビュー社血管医学Vascular Biology & Medicine
- Data Source
  KAKENHI-PROJECT-23590370
[Book] 実験医学30(8)2012
- Author(s)
  合田亘人, 鈴木智大, 金井麻衣
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23590370
[Book] 人生化学84(11)2012
- Author(s)
  合田亘人
- Data Source
  KAKENHI-PROJECT-23590370
[Book] HIFによる肝臓内糖・脂質代謝制御機構2012
- Author(s)
  合田　亘人
- Publisher
  生化学
- Data Source
  KAKENHI-PROJECT-23590370
[Book] 血管医学Vascular Biology & Medicine 13(4)2012
- Author(s)
  合田亘人, 長内康太
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-23590370
[Book] 概論－多彩な生命現象に働く低酸素応答システム2012
- Author(s)
  中山　恒、合田　亘人
- Publisher
  羊土社　実験医学
- Data Source
  KAKENHI-PROJECT-23590370
[Book] 低酸素転写制御因子とSDB2012
- Author(s)
  合田　亘人、鈴木　智大
- Publisher
  ライフサイエンス出版呼吸器NEWS&VIEWS
- Data Source
  KAKENHI-PROJECT-23590370
[Book] アルコールと医学生物学　アルコール性脂肪肝における低酸素応答性転写制御因子HIF-1の機能解析2011
- Author(s)
  合田　亘人
- Publisher
  東洋書店
- Data Source
  KAKENHI-PROJECT-23590370
[Book] 実験医学29(13)2011
- Author(s)
  合田亘人, 金井麻衣
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23590370
[Book] アルコールと医学生物学302011
- Author(s)
  合田亘人
- Publisher
  東洋出版
- Data Source
  KAKENHI-PROJECT-23590370
[Book] 実験医学　肝細胞の不均一性と肝代謝制御2011
- Author(s)
  合田　亘人
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23590370
[Book] 肝・消化管と低酸素2005
- Author(s)
  合田亘人, 槌谷夏子, 山本雄大
- Total Pages
  7
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-17570119
[Book] 炎症と免疫2005
- Author(s)
  合田亘人, 槌谷夏子, 山本雄大
- Total Pages
  140
- Publisher
  先端医学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570119
[Journal Article] Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis2024
- Author(s)
  Watanuki S et al
- Journal Title
  
  eLife
  
  Volume: 12
- DOI
  10.7554/elife.87674
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18137, KAKENHI-PROJECT-23K06416, KAKENHI-PROJECT-21K06072, KAKENHI-PROJECT-21K08431, KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-22K16298, KAKENHI-PROJECT-21H02957, KAKENHI-PROJECT-23K23797
[Journal Article] Mesenchymal loss of p53 alters stem cell capacity and models human soft tissue sarcoma traits.2023
- Author(s)
  Sorimachi Y, Kobayashi H, Shiozawa Y, Koide S, Nakato R, Shimizu Y, Okamura T, Shirahige K, Iwama A, Goda N, Takubo K, Takubo K.
- Journal Title
  
  Stem Cell Reports
  
  Volume: S2213-6711(23) Issue: 5 Pages: 00097-8
- DOI
  10.1016/j.stemcr.2023.03.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-20H05940, KAKENHI-PROJECT-23K06416, KAKENHI-PROJECT-21K08431, KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-22K16298, KAKENHI-PROJECT-22KJ2948, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-20H05686, KAKENHI-PROJECT-21H02957
[Journal Article] Epithelial cells remove precancerous cells by cell competition via MHC class I?LILRB3 interaction2021
- Author(s)
  Ayukawa Shiyu、Kamoshita Nagisa、Nakayama Jun、Teramoto Ryohei、Pishesha Novalia、Ohba Kenji、Sato Nanami、Kozawa Kei、Abe Hikari、Semba Kentaro、Goda Nobuhito、Fujita Yasuyuki、Maruyama Takeshi
- Journal Title
  
  Nature Immunology
  
  Volume: 22 Issue: 11 Pages: 1391-1402
- DOI
  10.1038/s41590-021-01045-6
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07345, KAKENHI-PROJECT-21K07107, KAKENHI-PROJECT-21H02768
[Journal Article] p38α plays differential roles in hematopoietic stem cell activity dependent on aging contexts2021
- Author(s)
  Sorimachi Yuriko、Karigane Daiki、Ootomo Yukako、Kobayashi Hiroshi、Morikawa Takayuki、Otsu Kinya、Kubota Yoshiaki、Okamoto Shinichiro、Goda Nobuhito、Takubo Keiyo
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 296 Pages: 100563-100563
- DOI
  10.1016/j.jbc.2021.100563
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21621, KAKENHI-PROJECT-18K08379, KAKENHI-PROJECT-19K17847, KAKENHI-PROJECT-19K17877, KAKENHI-PROJECT-21K08383, KAKENHI-PROJECT-20K07345
[Journal Article] Sima, a Drosophila homolog of HIF-1α, in fat body tissue inhibits larval body growth by inducing Tribbles gene expression.2021
- Author(s)
  Noguchi Koji、Yokozeki Kyosuke、Tanaka Yuko、Suzuki Yasuhiro、Nakajima Kazuki、Nishimura Takashi、Goda Nobuhito
- Journal Title
  
  Genes to Cells
  
  Volume: 27 Issue: 2 Pages: 145-151
- DOI
  10.1111/gtc.12913
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07345
[Journal Article] In vivo O2 imaging in hepatic tissues by phosphorescence lifetime imaging microscopy using Ir(III) complexes as intracellular probes2020
- Author(s)
  Mizukami Kiichi、Katano Ayaka、Shiozaki Shuichi、Yoshihara Toshitada、Goda Nobuhito、Tobita Seiji
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 21053-21053
- DOI
  10.1038/s41598-020-76878-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03509, KAKENHI-PROJECT-19K22947, KAKENHI-PROJECT-20K07345
[Journal Article] Transcriptional profiles in the chicken ductus arteriosus during hatching2019
- Author(s)
  Akaike T, Shinjo S, Ohmori E, Kajimura I, Goda N, Minamisawa S
- Journal Title
  
  PLoS One
  
  Volume: 14 Issue: 3 Pages: e0214139-e0214139
- DOI
  10.1371/journal.pone.0214139
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-17H01529
[Journal Article] Loss of hypoxia inducible factor-1alpha; aggravates gamma,deltaT cell-mediated inflammation during acetaminophen-induced liver injury2018
- Author(s)
  Suzuki T, Minagawa S, Yamazaki T, Arai T, Kanai M, Shinjo S, Goda N
- Journal Title
  
  Hepatol Commun
  
  Volume: in press Issue: 5 Pages: 571-581
- DOI
  10.1002/hep4.1175
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-17K08674
[Journal Article] Pyruvate dehydrogenase activation precedes the down-regulation of fatty acid oxidation in monocrotaline-induced myocardial toxicity in mice2018
- Author(s)
  Nakai Gaku、Shimura Daisuke、Uesugi Ken、Kajimura Ichige、Jiao Qibin、Kusakari Yoichiro、Soga Tomoyoshi、Goda Nobuhito、Minamisawa Susumu
- Journal Title
  
  Heart and Vessels
  
  Volume: 34 Issue: 3 Pages: 545-555
- DOI
  10.1007/s00380-018-1293-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19435, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-17H01529, KAKENHI-PROJECT-16K15184
[Journal Article] HIF-1-dependent lipin1 induction prevents excessive lipid accumulation in choline-deficient diet-induced fatty liver2018
- Author(s)
  Arai Takatomo、Tanaka Masako、Goda Nobuhito
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 14230-14230
- DOI
  10.1038/s41598-018-32586-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15757, KAKENHI-PLANNED-26111003
[Journal Article] Effects of aging on serum levels of lipid molecular species as determined by lipidomics analysis in Japanese men and women2018
- Author(s)
  Kawanishi Noriaki、Kato Yuki、Yokozeki Kyosuke、Sawada Shuji、Sakurai Ryota、Fujiwara Yoshinori、Shinkai Shoji、Goda Nobuhito、Suzuki Katsuhiko
- Journal Title
  
  Lipids in Health and Disease
  
  Volume: 17 Issue: 1 Pages: 135-135
- DOI
  10.1186/s12944-018-0785-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-17H02157
[Journal Article] Differential expression of Lutheran/BCAM regulates biliary tissue remodeling in ductular reaction during liver regeneration2018
- Author(s)
  Miura Yasushi、Matsui Satoshi、Miyata Naoko、Harada Kenichi、Kikkawa Yamato、Ohmuraya Masaki、Araki Kimi、Tsurusaki Shinya、Okochi Hitoshi、Goda Nobuhito、Miyajima Atsushi、Tanaka Minoru
- Journal Title
  
  eLife
  
  Volume: 7 Pages: 36572-36572
- DOI
  10.7554/elife.36572
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07180, KAKENHI-PLANNED-26110003, KAKENHI-PLANNED-26110007, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-18H02801, KAKENHI-PROJECT-18H02873, KAKENHI-PROJECT-16K07093, KAKENHI-PROJECT-16K09398, KAKENHI-PROJECT-17K19703
[Journal Article] Type I neuregulin1α is a novel local mediator to suppress hepatic gluconeogenesis in mice.2017
- Author(s)
  Arai T, Ono Y, Arimura Y, Sayama K, Suzuki T, Shinjo S, Kanai M, Abe S, Semba K, Goda N.
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 42959-42959
- DOI
  10.1038/srep42959
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-15K07129
[Journal Article] Disruption of the mitochondria-associated ER membrane (MAM) plays a central role in palmitic acid?induced insulin resistance2017
- Author(s)
  Shinjo Satoko、Jiang Shuying、Nameta Masaaki、Suzuki Tomohiro、Kanai Mai、Nomura Yuta、Goda Nobuhito
- Journal Title
  
  Exp Cell Res
  
  Volume: 359 Issue: 1 Pages: 86-93
- DOI
  10.1016/j.yexcr.2017.08.006
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-17K08674
[Journal Article] Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles.2016
- Author(s)
  Yamano, E., Sugimoto, M., Hirayama, A., Kume, S., Yamato, M., Jin, G., Tajima, S., Goda, N., Iwai, K., Fukuda, S., Yamaguti, K., Kuratsune, H., Soga, T., Watanabe, Y., and Kataoka, Y.
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Issue: 1 Pages: 34990-34990
- DOI
  10.1038/srep34990
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H00905, KAKENHI-PLANNED-26111003
[Journal Article] Low Cardiac Output Leads Hepatic Fibrosis in Right Heart Failure Model Rats.2016
- Author(s)
  Fujimoto Y, Urashima T, Shimura D, Ito R, Kawachi S, Kajimura I, Akaike T, Kusakari Y, Fujiwara M, Ogawa K, Goda N, Ida H, Minamisawa S
- Journal Title
  
  PLoS One
  
  Volume: 11(2) Issue: 2 Pages: e0148666-e0148666
- DOI
  10.1371/journal.pone.0148666
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08190, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-13J05481, KAKENHI-PROJECT-16K15184
[Journal Article] HIF-1α-PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity.2016
- Author(s)
  Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins D, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, Soma K, Koyama K, Katoh M, Sayama K, Goda N, Johnson RS, Manabe I, Nagai R, Komuro I.
- Journal Title
  
  Nat commun.
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-26111003
[Journal Article] HIF-1α in myeloid cells promotes adipose tissue remodeling toward insulin resistance.2016
- Author(s)
  Takikawa A, Mahmood A , Nawaz A, Kado T, Okabe K, Yamamoto S, Arif A, Senda S, Tsuneyama K, Ikutani M, Watanabe Y, Igarashi Y, Nagai Y, Takatsu K, Koizumi K, Imura J, Goda N, Sasahara M, Matsumoto M, Saeki K, Nakagawa T, Fujisaka S, Usui I, Tobe K.
- Journal Title
  
  Diabetes
  
  Volume: 65 Pages: 3649-3659
- NAID
  40021380120
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-26111003
[Journal Article] HIF-1alpha-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity2016
- Author(s)
  Semba, H., Takeda, N., Isagawa, T., Sugiura, Y., Honda, K., Wake, M., Miyazawa, H., Yamaguchi, Y., Miura, M., Jenkins, DM., Choi, H., Kim, JW., Asagiri, M., Cowburn, AS., Abe, H., Soma, K., Koyama, K., Katoh, M., Sayama, K., Goda, N., Johnson, RS., Manabe, I., Nagai, R., Komuro, I.
- Journal Title
  
  Nature Communications
  
  Volume: 7 Issue: 1 Pages: 11635-11635
- DOI
  10.1038/ncomms11635
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26110005, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-15H04824, KAKENHI-PROJECT-16H06145, KAKENHI-PROJECT-15K19369, KAKENHI-PROJECT-15K19372
[Journal Article] Karigane D, Kobayashi H, Morikawa T, Ootomo Y, Sakai M, Nagamatsu G, Kubota Y, Goda N, Matsumoto M, Nishimura EK, Soga T, Otsu K, Suematsu M, Okamoto S, Suda T, Takubo K.2016
- Author(s)
  Karigane D, Kobayashi H, Morikawa T, Ootomo Y, Sakai M, Nagamatsu G, Kubota Y, Goda N, Matsumoto M, Nishimura EK, Soga T, Otsu K, Suematsu M, Okamoto S, Suda T, Takubo K.
- Journal Title
  
  Cell Stem Cell
  
  Volume: 19 Issue: 2 Pages: 192-204
- DOI
  10.1016/j.stem.2016.05.013
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111003, KAKENHI-PLANNED-26115003, KAKENHI-PLANNED-26115005, KAKENHI-PROJECT-26221303, KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-15H04851, KAKENHI-PROJECT-15H04861, KAKENHI-PROJECT-15K10315, KAKENHI-PROJECT-16K15507
[Journal Article] The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages.2016
- Author(s)
  R. Hachiya, T. Shiihashi, I. Shirakawa, Y. Iwasaki, Y. Matsumura, Y. Oishi, Y. Nakayama, Y. Miyamoto, I. Manabe, K. Ochi, M. Tanaka, N. Goda, J. Sakai, T. Suganami, Y. Ogawa.
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Issue: 1 Pages: 28845-28845
- DOI
  10.1038/srep28845
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01371, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-16H05171, KAKENHI-PROJECT-16KT0110, KAKENHI-PROJECT-15K09423, KAKENHI-PROJECT-16K07220, KAKENHI-PROJECT-16K15234, KAKENHI-PROJECT-16K19387, KAKENHI-PROJECT-16K19631, KAKENHI-PROJECT-16H06390
[Journal Article] Potential biomarkers of fatigue identified by plasma metabolome analysis in rats.2015
- Author(s)
  Kume, S., Yamato, M., Tamura, Y., Jin, G., Nakano, M., Miyashige, Y., Eguchi, A., Ogata, Y., Goda, N., Iwai, K., Yamano, E., Watanabe, Y., Soga, T., and Kataoka, Y.
- Journal Title
  
  PLOS ONE
  
  Volume: 10(3) Issue: 3 Pages: e0120106-e0120106
- DOI
  10.1371/journal.pone.0120106
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-25108515, KAKENHI-PROJECT-25460399, KAKENHI-PROJECT-25750169, KAKENHI-PROJECT-25882051, KAKENHI-PLANNED-26111003, KAKENHI-PUBLICLY-15H00905
[Journal Article] Heterozygous deletion of sarcolipin maintains normal cardiac function.2015
- Author(s)
  Shimura D, Kusakari Y, Sasano T, Nakashima Y, Nakai G, Jiao Q, Jin M, Yokota T, Ishikawa Y, Nakano A, Goda N, Minamisawa S.
- Journal Title
  
  Am J Physiol Heart Circ Physiol.
  
  Volume: 310(1) Issue: 1 Pages: 92-103
- DOI
  10.1152/ajpheart.00411.2015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08190, KAKENHI-PROJECT-15K18975, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-26893124, KAKENHI-PROJECT-25461045, KAKENHI-PROJECT-24390200, KAKENHI-PROJECT-16H05300, KAKENHI-PROJECT-16K15205, KAKENHI-PROJECT-16K15184
[Journal Article] nnate Response to Human Cancer Cells with or without IL-2 Receptor Common γ-Chain Function in NOD Background Mice Lacking Adaptive Immunity.2015
- Author(s)
  Nishime C, Kawai K, Yamamoto T, Katano I, Monnai M, Goda N, Mizushima T, Suemizu H, Nakamura M, Murata M, Suematsu M, Wakui M.
- Journal Title
  
  J Immunol
  
  Volume: 195 Issue: 4 Pages: 1883-1890
- DOI
  10.4049/jimmunol.1402103
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111003, KAKENHI-PUBLICLY-26117726, KAKENHI-PROJECT-23249030, KAKENHI-PROJECT-25250012, KAKENHI-PROJECT-15H04355, KAKENHI-PROJECT-25430139
[Journal Article] Hypoxia and fatty liver.2014
- Author(s)
  Suzuki T, Shinjo S, Arai T, Kanai M, Goda N.
- Journal Title
  
  World J Gastroenterol.
  
  Volume: 20 Issue: 41 Pages: 15087-15097
- DOI
  10.3748/wjg.v20.i41.15087
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-26111003
[Journal Article] Transcription profiles of the ductus arteriosus in Brown-Norway rat with irregular elastic fiber formation2014
- Author(s)
  Hsieh YT, Liu NM, Ohmori E, Y okota T, Kajimura I, Akaike T, Ohshima T, Goda N, Minamisawa S
- Journal Title
  
  Circ J
  
  Volume: 8(5) Pages: 1224-33
- NAID
  130003391069
- Data Source
  KAKENHI-PROJECT-23390277
[Journal Article] Transcription Profiles of the Ductus Arteriosus in Brown-Norway Rats With Irregular Elastic Fiber Formation2014
- Author(s)
  Hsieh YT, Liu NM, Ohmori E, Yokota T, Kajimura I, Akaike T, Ohshima T, Goda N, Minamisawa S.
- Journal Title
  
  Circ J
  
  Volume: 78 Issue: 5 Pages: 1224-1233
- DOI
  10.1253/circj.CJ-13-1029
- NAID
  130003391069
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25860885, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-26293249
[Journal Article] Metabolomic profiling analysis reveals chamber-dependent metabolite patterns in the mouse heart.2013
- Author(s)
  Shimura D, Nakai G, Jiao Q, Osanai K, Kashikura K, Endo K, Soga T, Goda N, Minamisawa S
- Journal Title
  
  American Journal of Physiology, Heart and Circul atory Physiology
  
  Volume: 305(4) Issue: 4 Pages: H494-H505
- DOI
  10.1152/ajpheart.00867.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J05481, KAKENHI-PROJECT-23390277, KAKENHI-PROJECT-23590370
[Journal Article] Hypoxia-inducible factor-1 is a determinant of lobular structure and oxygen consumption in the liver.2013
- Author(s)
  Tsukada K, Tajima T, Hori S, Matsuura T, Johnson RS, Goda N, Suematsu M.
- Journal Title
  
  Microcirculation
  
  Volume: in press Issue: 5 Pages: 385-393
- DOI
  10.1111/micc.12033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590370
[Journal Article] Adipose Tissue Hypoxia Induces Inflammatory M1 Polarity of Macrophages in HIF-1a-Dependent and HIF-1a-Independent Manners in Obese Mice.2013
- Author(s)
  Fujisaka S, Usui I, Ikutani M, Aminuddin A, Takikawa A, Tsuneyama K, Mahmood A, Goda N, Nagai Y, Takatsu K, Tobe K..
- Journal Title
  
  Diabetologia
  
  Volume: 56(6) Issue: 6 Pages: 1403-1412
- DOI
  10.1007/s00125-013-2885-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590370, KAKENHI-PUBLICLY-24117708, KAKENHI-PROJECT-24390119, KAKENHI-PROJECT-24390181, KAKENHI-PROJECT-24590577, KAKENHI-PUBLICLY-25126707, KAKENHI-PROJECT-25461333
[Journal Article] Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells.2013
- Author(s)
  Takubo K
- Journal Title
  
  Cell Stem Cell
  
  Volume: 12 Issue: 1 Pages: 49-61
- DOI
  10.1016/j.stem.2012.10.011
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001, KAKENHI-PROJECT-23249053, KAKENHI-PROJECT-23590370, KAKENHI-PROJECT-23618011, KAKENHI-PROJECT-23689049, KAKENHI-PROJECT-24240119, KAKENHI-PLANNED-22130004, KAKENHI-PLANNED-22134007, KAKENHI-PUBLICLY-23118527, KAKENHI-PUBLICLY-23130507, KAKENHI-PUBLICLY-24116522
[Journal Article] Heterofunctional nanosheet controlling cell adheasion properties by collagen coating2012
- Author(s)
  Niwa D, Fujie T, Lang T, Goda N, Takeoka S
- Journal Title
  
  J. Biomater. Appl.
  
  Volume: 27 Pages: 131-141
- Data Source
  KAKENHI-PROJECT-21300181
[Journal Article] Hypoxia-inducible factors and their roles in energy metabolism.2012
- Author(s)
  Goda N, Kanai M.
- Journal Title
  
  Int J Hematol
  
  Volume: 95 Issue: 5 Pages: 457-463
- DOI
  10.1007/s12185-012-1069-y
- NAID
  10030632790
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590370
[Journal Article] HIF-1 in T cells ameliorated dextran sodium sulfate-induced murine colitis.2012
- Author(s)
  Higashiyama M, Hokari R, Hozumi H, Kurihara C, Ueda T, Watanabe C, Tomita K, Nakamura M, Komoto S, Okada Y, Kawaguchi A, Nagao S, Suematsu M, Goda N, Miura S.
- Journal Title
  
  J Leukoc Biol
  
  Volume: 91(6) Issue: 6 Pages: 901-909
- DOI
  10.1189/jlb.1011518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590370
[Journal Article] HIF-1αinduction suppresses excessive lipid accumulation in alcoholic fatty liver in mice2012
- Author(s)
  Nishiyama Y, Goda N, 他9名
- Journal Title
  
  J Hepatol
  
  Volume: 56(2) Issue: 2 Pages: 441-447
- DOI
  10.1016/j.jhep.2011.07.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590370, KAKENHI-PROJECT-23657150
[Journal Article] Hypoxia biology in health and disease2012
- Author(s)
  Goda N
- Journal Title
  
  Int J Hematol
  
  Volume: 95 Issue: 5 Pages: 455-456
- DOI
  10.1007/s12185-012-1084-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590370
[Journal Article] Disruption of HIF-1α in Hepatocytes Impairs Glucose Metabolism in Diet-induced Obesity Mice2011
- Author(s)
  Ochiai, D.
- Journal Title
  
  Biochem.Biophys.Res.Commun
  
  Volume: 415 Issue: 3 Pages: 445-449
- DOI
  10.1016/j.bbrc.2011.10.089
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134007, KAKENHI-PROJECT-23590370, KAKENHI-PROJECT-23657150
[Journal Article] Heterofunctional nanosheet controlling cell adhesion properties by collagen coating2011
- Author(s)
  D.Niwa, N.Goda, S.Takeoka, ほか1名
- Journal Title
  
  J.Biomat.Appl.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300181
[Journal Article] Erythrocytes with T-state-stabilized hemoglobin as a therapeutic tool for postischemic liver dysfunction2006
- Author(s)
  Suganuma, K., Tsukada, K., Kashiba, M., Tsuneshige, A., Furukawa, T., Kubota, T., Goda, N., Kitajima, M., Yonetani, T., Suematsu, M.
- Journal Title
  
  Antioxid. Redox Signal. 8
  
  Pages: 18741-1855
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570119
[Journal Article] Carbon monoxide from heme oxygenase-2 is a tonic regulator against NO-dependent vasodilatation in the adult rat cerebral microcirculation2005
- Author(s)
  Ishikawa, M., Kajimura, M., Adachi, T., Maruyama, K., Makino, N., Goda, N., Yamaguchi, T., Sekizuka, E., Suematsu, M.
- Journal Title
  
  Circ.Res. 97
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570119
[Journal Article] Carbon monoxide as a guardian against hepatobiliary dysfunction2005
- Author(s)
  Suematsu, M., Tsukada, K., Tajima, T., Yamamoto, T., Ochiai, D., Watanabe, H., Yoshimura, Y., Goda.N.
- Journal Title
  
  Alcohol Clin. Exp. Res. 29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570119
[Journal Article] Hydrogen sulfide as an endogenous modulator of biliary bicarbonate excretion in the rat liver2005
- Author(s)
  Fujii, K., Sakuragawa, T., Kashiba, M., Sugiura, Y., Kondo, M., Maruyama, K., Goda, N., Nimura, Y., Suematsu, M.
- Journal Title
  
  Antioxid Redox Signal. 7
  
  Pages: 788-794
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570119
[Journal Article] Cadmium exposure alters metabolomics of sulfur-containing amino acids in rat testes2005
- Author(s)
  Sugiura, Y., Kashiba, M., Maruyama, K., Hoshikawa, K., Sasaki, R., Saito, K., Kimura, H., Goda, N., Suematsu, M.
- Journal Title
  
  Antioxid. Redox Signal. 7
  
  Pages: 781-787
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570119
[Journal Article] Organ design for generation and reception of CO : lessons from the liver.2002
- Author(s)
  Kajimura M, Goda N, Suematsu M.
- Journal Title
  
  Antioxid Redox Signal 4・4
  
  Pages: 633-637
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370063
[Journal Article] Stabilization of mast cells by heme oxygenase-1 : an anti-inflammatory role.2002
- Author(s)
  Takamiya R, Murakami M, Kajimura M, Goda N, Makino N, Takamiya Y, Yamaguchi T, Ishimura Y, Hozumi N, Suematsu M.
- Journal Title
  
  Am J Physiol Heart Circ Physiol 283・3
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370063
[Patent] ニューレグリン1a様活性を有するポリペプチド及び糖尿病治療用医薬組成物2017
- Inventor(s)
  合田　亘人、新井　理智、大野　友美絵
- Industrial Property Rights Holder
  合田　亘人、新井　理智、大野　友美絵
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-17K08674
[Presentation] 肝臓由来のニューレグリン 1 による代謝制御2023
- Author(s)
  合田　亘人
- Organizer
  第 32 回プロメテウスの会
- Data Source
  KAKENHI-PROJECT-23K06416
[Presentation] 肝臓の低酸素応答により稼働する臓器間クロストーク2023
- Author(s)
  合田　亘人
- Organizer
  第 96 回日本生化学会
- Data Source
  KAKENHI-PROJECT-23K06416
[Presentation] 代謝・炎症を司る低酸素応答と肝疾患2023
- Author(s)
  合田　亘人
- Organizer
  第 47 回日本鉄バイオサイエンス学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K06416
[Presentation] 代償性膵島肥大にかかわるヘパトカイン受容体の同定とその機能解析2022
- Author(s)
  合田　亘人
- Organizer
  第29回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-20K07345
[Presentation] 新規ヘパトカインによる代償性膵島肥大を介した血糖調節機構の解明2022
- Author(s)
  合田　亘人
- Organizer
  第95回日本生化学会
- Data Source
  KAKENHI-PROJECT-20K07345
[Presentation] 肝臓と膵臓を繋ぐ新規ヘパトカインの探索とその機能解析2021
- Author(s)
  合田亘人
- Organizer
  第7回肝臓と糖尿病・代謝研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07345
[Presentation] HIF-PHDを介した低酸素感知・応答システムの制御機構2020
- Author(s)
  合田亘人
- Organizer
  第63回日本腎臓学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07345
[Presentation] 2型糖尿病で肝臓から分泌される Hepatokine X は膵島肥大を誘導することで血糖調節にかかわっている2020
- Author(s)
  86.林絵莉子、新井理智、合田亘人
- Organizer
  第27回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-20K07345
[Presentation] 低酸素応答の疾患生物学2020
- Author(s)
  合田亘人
- Organizer
  第88回日本医科大学医学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07345
[Presentation] Pathological role of HIF-1 in the liver2018
- Author(s)
  Nobuhito Goda
- Organizer
  Hypoxia Research Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] 自然免疫様T細胞のHIF-1による急性炎症制御機構の解明2018
- Author(s)
  合田亘人
- Organizer
  第91回日本生化学会
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] 新しい糖新生調節因子の探索とその機能解析2018
- Author(s)
  合田亘人
- Organizer
  第5回肝臓と糖尿病・代謝研究会
- Invited
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] Pathological role of HIF-1 in the liver2018
- Author(s)
  合田亘人
- Organizer
  第6回低酸素研究会・酸素生物学領域国際シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] Gpnmbによる肝糖新生抑制機構の解明2017
- Author(s)
  大野友美絵、有村祐次郎、新井理智、合田亘人
- Organizer
  第24回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-17K08674
[Presentation] 肝臓による新しい生体内糖代謝調節機構2017
- Author(s)
  合田　亘人
- Organizer
  第24回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-17K08674
[Presentation] ニューレグリン1を介した肝糖新生調節機構の解明2017
- Author(s)
  合田　亘人、新井　理智、大野　友美絵
- Organizer
  第４回肝臓と糖尿病・代謝研究会
- Data Source
  KAKENHI-PROJECT-17K08674
[Presentation] 低酸素応答システムが拓く代謝性疾患の新しい病態理解2016
- Author(s)
  合田亘人
- Organizer
  第20回酸素ダイナミクス研究会
- Place of Presentation
  東京
- Year and Date
  2016-11-19
- Invited
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] Metabolic diseases and HIF-12016
- Author(s)
  Goda N.
- Organizer
  第89回生化学会大会
- Place of Presentation
  仙台国際センター
- Year and Date
  2016-09-26
- Invited
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] The regulation of in vitro megakaryocyte differentiation by hypoxia.2015
- Author(s)
  Kanai M, Houkuwa K, Goda N
- Organizer
  私立大学戦略的研究基盤形成支援事業「ストレス応答制御に基づく次世代健康寿命科学の研究拠点形成」第三回成果報告会
- Place of Presentation
  東京（早稲田大学）
- Year and Date
  2015-03-06
- Data Source
  KAKENHI-PROJECT-25860150
[Presentation] Pyruvate dehydrogenase activation precedes the down-regulation of fatty acid oxidation in monocrotaline-administrated mouse hearts.2014
- Author(s)
  Gaku Nakai, Ken Uesugi, Daisuke Shimura, Ichige Kajimura, Qibin Jiao, Yoichiro Kusakari, Kasumi Kashikura, Keiko Endo, Tomoyoshi Soga, Nobuhito Goda, Susumu Minamisawa.
- Organizer
  The 58th Annual Meeting of the Biophysical Society.
- Place of Presentation
  Moscone Center, San Franscisco, USA
- Data Source
  KAKENHI-PROJECT-23390277
[Presentation] ニワトリ胚動脈管リモデリングにおける弾性線維断片化・形成不全の確認2014
- Author(s)
  大森衣里子、赤池　徹、梶村市毛、合田亘人、南沢　享
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学　郡元キャンパス
- Data Source
  KAKENHI-PROJECT-23390277
[Presentation] 乳酸による心房の興奮収縮連関に対する阻害効果2014
- Author(s)
  志村大輔、草刈洋一郎、合田亘人、南沢　享
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学　郡元キャンパス
- Data Source
  KAKENHI-PROJECT-23390277
[Presentation] 低酸素応答システムによる代謝制御2013
- Author(s)
  合田亘人
- Organizer
  第50回日本臨床分子医学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590370
[Presentation] Role of HIF-1 in the regulation of hepatic lipid metabolism2012
- Author(s)
  Nobuhito Goda
- Organizer
  The 33^<rd> NAITO CONFERENCE ON OXYGEN BIOLOGY:HYPOXIA, OXIDATIVE STRESS AND DISEASES
- Place of Presentation
  SAPPPORO
- Data Source
  KAKENHI-PROJECT-23590370
[Presentation] 低酸素応答による肝代謝機能制御2012
- Author(s)
  合田亘人
- Organizer
  第19回肝細胞研究会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590370
[Presentation] HIF-1 Regulates Hepatic Lipid Metabolism in a Context-dependent Manner2012
- Author(s)
  Nobuhito Goda
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23590370
[Presentation] 抗生物質担持ポリ-L-乳酸ナノシートの薬物徐放能と抗菌能評価2011
- Author(s)
  小出真嗣, 丹羽大輔, 合田亘人, 武岡真司
- Organizer
  第60回高分子学会年次大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21300181
[Presentation] 抗生物質担持ボリ-L-乳酸ナノシートの薬物徐放能と抗菌能評価2011
- Author(s)
  小出真嗣、丹羽大輔、合田亘人、武岡真司
- Organizer
  第60回高分子学会年次大会
- Place of Presentation
  大阪
- Year and Date
  2011-05-25
- Data Source
  KAKENHI-PROJECT-21300181
[Presentation] 肝代謝制御における低酸素応答の機能解析2011
- Author(s)
  合田亘人
- Organizer
  第84回日本生化学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23590370
[Presentation] 肝臓切開に伴う多量出血部位におけるポリ-L-乳酸ナノシートの癒着防止能評価2011
- Author(s)
  小出真嗣, 丹羽大輔, 合田亘人, 武岡真司
- Organizer
  第33回日本バイオマテリアル学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21300181
[Presentation] Deletion of hepatic HIF-1a gene aggravated alcohol-induced steatosis in mice2011
- Author(s)
  Goda N
- Organizer
  International Symposium on ALPD and Cirrhosis
- Place of Presentation
  Fukuoka
- Data Source
  KAKENHI-PROJECT-23590370
[Presentation] Analysis of the interaction between cells and the different types of nanosheets2010
- Author(s)
  Niwa D, Fujie T, Lang T, Goda N, Takeoka S
- Organizer
  239th ACS National Meeting
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-21300181
[Presentation] 物性の異なる高分子超薄膜の構築と細胞との相互作用解析2009
- Author(s)
  丹羽大輔, 藤枝俊宣, 合田亘人, 武岡真司
- Organizer
  日本化学会第3回関東支部大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21300181
[Presentation] 心不全紀副腎におけるマクロファージの浸潤とアルドステロン異常産生
- Author(s)
  伊藤健太郎、佐野元昭、三谷芙美子、Yan Xiaoian、松橋智弘、勝俣良紀、安西淳、木内謙一郎、竹島亜希子、吉田尚弘、山本恒久、新村健、合田亘人、福田恵一
- Organizer
  第三回Molecular Cardiovascular ConferenceII
- Place of Presentation
  北海道余市郡
- Data Source
  KAKENHI-PROJECT-23590370
[Presentation] マウス脂肪前駆細胞由来巨核球における脂質代謝を介した分化制御機構の解明
- Author(s)
  法桑　かおり, 金井　麻衣, 合田　亘人
- Organizer
  第37回分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25860150
[Presentation] アルコール性脂肪肝の発症機構における低酸素応答の病態生理学的意義
- Author(s)
  合田　亘人
- Organizer
  第48回日本肝臓学会総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23590370
[Presentation] ショウジョウバエモデルを用いたSima/HIF-1aシグナルによる個体の発生と老化の制御機構の解析
- Author(s)
  平本美香子、大野貴久、合田亘人、松田七美
- Organizer
  第85回日本生化学会総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23590370
[Presentation] 低酸素応答による巨核球分化機構の解明
- Author(s)
  金井　麻衣, 法桑　かおり, 合田　亘人
- Organizer
  第37回分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25860150
[Presentation] コリン欠乏食誘導性NAFLDモデルにおけるHIF1の機能解析
- Author(s)
  新井理智、加藤祐樹、合田亘人
- Organizer
  第85回日本生化学会総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23590370
[Presentation] Pathological Mechanism of ALS2/Alsin in a Drosophila Familial Amyotrophic Lateral Sclerosis Model
- Author(s)
  府川直矢、堤香菜子、合田亘人、松田七美
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23590370
[Presentation] Hypoxic response and lipid metabolism
- Author(s)
  Nobuhito Goda
- Organizer
  International Symposium on Integration of Chemistry and Bioscience
- Place of Presentation
  Tokyo
- Invited
- Data Source
  KAKENHI-PROJECT-23590370
[Presentation] in vitroにおけるにおける巨核球分化誘導と代謝制御との関連性
- Author(s)
  金井　麻衣, 法桑　かおり, 松原　由美子, 池田　康夫, 合田　亘人
- Organizer
  私立大学戦略的研究基盤形成支援事業「ストレス応答制御に基づく次世代健康寿命科学の研究拠点形成」第二回成果報告会
- Place of Presentation
  早稲田大学
- Data Source
  KAKENHI-PROJECT-25860150
[Presentation] Functional analysis of Sima/HIF-1α signaling in Drosophila neurodegenerative disease models
- Author(s)
  大野貴久、合田亘人、松田七美
- Organizer
  第10回　日本ショウジョウバエ研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590370
[Presentation] Biological roles of HIFs in the maintenance of carbohydrate metabolism in liver
- Author(s)
  加藤早由華、合田亘人
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23590370
[Presentation] 低酸素応答による肝代謝機能制御
- Author(s)
  合田　亘人
- Organizer
  第19回肝細胞研究会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-23590370
[Presentation] 低酸素応答システムを介した非アルコール性脂肪性肝疾患の発症制御機構
- Author(s)
  合田　亘人、新井　理智、加藤　祐樹
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590370
[Presentation] 低酸素応答性転写制御因子HIF-1を介した非アルコール性脂肪肝抑制機構の解明
- Author(s)
  合田　亘人
- Organizer
  第49回日本肝臓学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590370
[Presentation] HIF-1 regulates lipid metabolism in the liver
- Author(s)
  Nobuhito Goda
- Organizer
  New Frontiers of Metabolism Research in Biomedical Sciences
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590370
[Presentation] Protective role of hepatic HIF-1 against liver steatosis in non-alcoholic fatty liver disease
- Author(s)
  Nobuhito Goda
- Organizer
  Keystone Symposia
- Place of Presentation
  Colorado
- Data Source
  KAKENHI-PROJECT-23590370
[Presentation] Hypoxic responses and alcoholic fatty liver
- Author(s)
  Nobuhito Goda
- Organizer
  16th Congress of International Society for Biomedical Research on Alcoholism
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590370
[Presentation] Relevance of metabolic systems to in vitro megakaryocyte differentiation.
- Author(s)
  Kanai M, Houkuwa K, Matsubara Y, Ikeda Y, Goda N.
- Organizer
  第36回分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-25860150
[Presentation] Role of HIF-1 in the regulation of hepatic lipid metabolism
- Author(s)
  Nobuhito Goda
- Organizer
  The 33rd NAITO CONFERENCE ON OXYGEN BIOLOGY: HYPOXIA, OXIDATIVE STRESS AND DISEASES
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590370
[Presentation] 低酸素応答システムによる代謝制御
- Author(s)
  合田　亘人
- Organizer
  第50回日本臨床分子医学会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23590370
[Presentation] Mechanism of in body size control via Sima/HIF-1α signaling in Drosophila
- Author(s)
  平本美香子、大野貴久、合田亘人、松田七美
- Organizer
  第１０回　日本ショウジョウバエ研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590370
[]

1. SUEMATSU Makoto (00206385)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. TAKEOKA Shinji (20222094)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. MINAMISAWA Susumu (40257332)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. YOKOYAMA Utako (70404994)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. ISHIKAWA Yoshihiro (40305470)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NAKAMURA Tomoyuki (20362527)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SUGIMOTO Yukihiko (80243038)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. AOKI Hiroki (60322244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TSUKADA Kosuke (00351883)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. KABE Yasuaki (20397037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KANAI MAI (30528526)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
12. MATHUBARA Yumiko (26461410)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. Nangaku Masaomi (90311620)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. ISHIKAWA Hiromichi (20051667)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KOYASU Shigeo (90153684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. OHTEKI Toshiaki (50233200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. WATANABE Mamoru (10175127)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. HACHIMURA Satoshi (40238019)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. ONISHI Yasuyuki (70201382)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. SHIMAZU Motohide (70124948)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 武田憲彦 (40422307)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. 日比紀文 (50129623)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 阿部啓子 (10151094)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 田之倉優 (60136786)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 清水誠 (30114507)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 江川毅 (10232935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. HOUKUWA Kaori

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
28. YAMAGUCHI Yoshifumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. TAKUBO Keiyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 片岡洋祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
31. 草刈洋一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
32. 土田英俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
33. 白髭克彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 田中昌子(橘昌子)

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 飛田成史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 吉川大和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 菅波孝祥

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

GODA Nobuhito 合田 亘人

合田 亘人 ゴウダ ノブヒト

合田 宣人 ゴウダ ノブヒト

Research Projects

Research Products

Co-Researchers

糖尿病における膵B細胞の分化変容に対する新規ヘパトカインの病態機能解析Principal Investigator

Principal Investigator

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Review Section

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Novel mechanism of blood glucose regulation based on inter-organ crosstalk mediated by liver-derived proteins.Principal Investigator

Principal Investigator

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Review Section

Research Institution

Research on pathological role of a novel hepatokine, neuregulin 1, in diabetes mellitusPrincipal Investigator

Principal Investigator

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Research Institution

;The roles of hypoxia signaling in the pathogenesis of lifestyle related diseases

Principal Investigator

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Review Section

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The regulation of in vitro megakaryocyte differentiation and platelet production by hypoxia

Principal Investigator

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Research Institution

Molecular mechanisms of ductus arteriosus closure

Principal Investigator

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Research Institution

Analysis of pathological roles of hypoxic responses in the regulation of organ metabolism in fatty liver diseasesPrincipal Investigator

Principal Investigator

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Development of functional polymer nanosheet for the treatment of burn injury and gastrointestinal tissue defects.

Principal Investigator

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Role of HIF-1 in the regulation of inflammatory responses through sensing alterations in microenvironments of immune cellsPrincipal Investigator

Principal Investigator

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Research Institution

Role of hypoxia inducible factor-1α in the regulation of hypoxic responses in liver.

Principal Investigator

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Analysis of molecular mechanisms by which heme oxygenase-carbon monoxide pathway regulates cellular functions under physiological and pathophysiological conditions using newly developed gene targeting mice.

Principal Investigator

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Investigation of immuno-regulatory competency of dietary substances and its application for our own beneficial ends

Principal Investigator

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[Book] 細胞2013

Author(s)

Publisher

GODA Nobuhito 合田亘人

合田亘人ゴウダノブヒト

合田宣人ゴウダノブヒト

[Book] 低酸素シグナリング　-HIFシグナリング-2012

[Book] アルコールと医学生物学　アルコール性脂肪肝における低酸素応答性転写制御因子HIF-1の機能解析2011

[Book] 実験医学　肝細胞の不均一性と肝代謝制御2011