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KAWANE Tetsuya  川根 徹也

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KAWANE Thtsuya  川根 徹也

川根 徹也  カワネ テツヤ

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Researcher Number 00265208
Other IDs
Affiliation (based on the past Project Information) *help 2023: 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員
2018: 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員
2014 – 2018: 長崎大学, 医歯薬学総合研究科(歯学系), 技術職員
2003 – 2006: 奥羽大学, 歯学部, 講師
1998 – 2001: 奥羽大学, 歯学部, 助手
1995: 奥羽大学, 歯学部, 助手
Review Section/Research Field
Principal Investigator
病態科学系歯学(含放射線系歯学) / Functional basic dentistry / Surgical dentistry
Except Principal Investigator
Morphological basic dentistry / Broad Section I / Functional basic dentistry / Functional basic dentistry
Keywords
Principal Investigator
osteoblast / PTHrP receptor / PTH / promoter / transcriptional factor / gel mobility shift assay / PTHrP / initiator / siRNA / oral cancer … More / 転写因子 / 骨代謝 / アイソフォーム / 骨・軟骨組織 / 骨・軟骨 / isoform / Runx2 / south western / PTHrP recetor / MAP kinase / 44MAP kinase / p42 / IGF-I / 甲状腺・副甲状腺摘出手術 / 絶食 / 転写制御 / 受容体 / 副甲状腺ホルモン … More
Except Principal Investigator
エンハンサー / Runx2 / 軟骨細胞 / 骨芽細胞 / 変形性関節症 / 歯学 / 発生・分化 / 細胞・組織 / 発現制御 / Mineralization / prenylation / BMP-2 / MC3T3-E1 cells / Statins / Hck / Antxr1 / オステオカルシン / ヘッジホッグ / Wnt / FGF / アポトーシス / 血管進入 / 分化転換 / 遺伝子 / 創薬 / 口腔解剖学 / 基礎歯学 / 転写活性 / 象牙芽細胞突起 / Map1B / 免疫組織化学 / 象牙芽細胞分化 / 遺伝子改変マウス / MAP1B / ネスチン / タウ蛋白質 / P13 kinase / Vascular endotherial growth factor (VEGF) / mineralization / hypoxia responsive elements (HRE) / vascular endothelial growth factor (VEGF) / statins / Prenylation / PI3 kinase / Vascular endotherial growth factor(VEGF) / Transcriptional regulation / Vitamin D receptor / 24-hydroxylase / 1a-hydroxylase / Glucocorticoid / Osteoporosis / 転写調節 / ビタミンD受容体 / 24-水酸化酵素 / 1α-水酸化酵素 / グルココルチコイド / 骨粗鬆症 / Cbfb / Galnt3 / 転写因子 Less
  • Research Projects

    (12 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (15 People)
  •  Elucidation of the mechanism in the regulation of chondrocyte-specific Runx2 enhancer and development of the drug for osteoarthritis

    • Principal Investigator
      Komori Toshihisa
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Review Section
      Broad Section I
    • Research Institution
      Nagasaki University
  •  Analysis of the function of microtubule-associated protein tau (Mapt) and nestin in the formation of odontoblast processes using the genetically modified mice

    • Principal Investigator
      MIYAZAKI Toshihiro
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Nagasaki University
  •  Studies for expression and function of Runx2 isoformsPrincipal Investigator

    • Principal Investigator
      KAWANE Tetsuya
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Nagasaki University
  •  Runx2遺伝子の軟骨細胞特異的エンハンサーの同定とその制御機構の解明

    • Principal Investigator
      KOMORI Toshihisa
    • Project Period (FY)
      2014
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Nagasaki University
  •  Elucidation of the transcriptional regulation of Runx2 and development of the drugs for osteoporosis and osteoarthritis

    • Principal Investigator
      KOMORI Toshihisa
    • Project Period (FY)
      2014 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Nagasaki University
  •  Analysis of transcription enhancing factor for PTH receptor that controls bone metabolismPrincipal Investigator

    • Principal Investigator
      KAWANE Tetsuya
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Ohu University
  •  Mechanism of osteoblast differantiation by statins via stimulation of VEGF gene transcription

    • Principal Investigator
      HORIUCHI Noboru
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Ohu University
  •  Identification of transcription enhancing fator for PTH receptor and analysis it's mechanism at jaw bone resorption site by oral cancerPrincipal Investigator

    • Principal Investigator
      KAWANE Tesuya
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Ohu University
  •  骨芽細胞におけるPTH/PTHrP受容体遺伝子発現調節に関する研究Principal Investigator

    • Principal Investigator
      川根 徹也
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      病態科学系歯学(含放射線系歯学)
    • Research Institution
      Ohu University
  •  骨芽細胞におけるIGF-IによるPTH受容体遺伝子発現抑制機構の解明Principal Investigator

    • Principal Investigator
      川根 徹也
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      病態科学系歯学(含放射線系歯学)
    • Research Institution
      Ohu University
  •  Disorder of vitamin D metabolism in steroid-induced osteoporosis

    • Principal Investigator
      HORIUCHI Noboru
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Functional basic dentistry
    • Research Institution
      Ohu University
  •  副甲状腺機能異常と副甲状腺ホルモン受容体遺伝子発現の関係Principal Investigator

    • Principal Investigator
      川根 徹也
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      病態科学系歯学(含放射線系歯学)
    • Research Institution
      Ohu University

All 2018 2017 2016 2015 2014 2005 2004 2003 Other

All Journal Article Presentation

  • [Journal Article] Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation by regulating Fgfr2 and Fgfr32018

    • Author(s)
      Kawane Tetsuya、Qin Xin、Jiang Qing、Miyazaki Toshihiro、Komori Hisato、Yoshida Carolina Andrea、Matsuura-Kawata Viviane Keiko dos Santos、Sakane Chiharu、Matsuo Yuki、Nagai Kazuhiro、Maeno Takafumi、Date Yuki、Nishimura Riko、Komori Toshihisa
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 13551-13551

    • DOI

      10.1038/s41598-018-31853-0

    • NAID

      120006987946

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19654, KAKENHI-PROJECT-16H06393, KAKENHI-PROJECT-18H05283, KAKENHI-PROJECT-17J04196, KAKENHI-PROJECT-17K17087, KAKENHI-PROJECT-17K17094
  • [Journal Article] 骨形成を制御する転写因子Runx2とOsterix2017

    • Author(s)
      川根徹也,小守壽文
    • Journal Title

      分子リウマチ治療

      Volume: 10 Pages: 28-32

    • Data Source
      KAKENHI-PROJECT-26221310
  • [Journal Article] 骨形成を制御する転写因子Runx2とOsterix2017

    • Author(s)
      川根徹也,小守壽文
    • Journal Title

      分子リウマチ治療

      Volume: 10 Pages: 28-32

    • Data Source
      KAKENHI-PROJECT-15K11048
  • [Journal Article] Cbfb2 Isoform Dominates More Potent Cbfb1 and Is Required for Skeletal Development.2016

    • Author(s)
      Jiang Q, Qin X, Kawane T, Komori H, Matsuo Y, Taniuchi I, Ito K, Izumi S, Komori T
    • Journal Title

      J Bone Miner Res

      Volume: 印刷中 Issue: 7 Pages: 1391-1404

    • DOI

      10.1002/jbmr.2814

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K11048, KAKENHI-PROJECT-26670811, KAKENHI-PROJECT-26293109, KAKENHI-PROJECT-26221310, KAKENHI-PROJECT-26290040, KAKENHI-PROJECT-16K15781, KAKENHI-PROJECT-16K20422
  • [Journal Article] Cbfb regulates bone development by stabilizing Runx family proteins.2015

    • Author(s)
      Qin X, Jiang Q, Matsuo Y, Kawane T, Komori H, Moriishi T, Taniuchi I, Ito K, Kawai Y, Rokutanda S, Izumi S, Komori T.
    • Journal Title

      Journal of bone and mineral research

      Volume: 30 Issue: 4 Pages: 706-714

    • DOI

      10.1002/jbmr.2379

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25861748, KAKENHI-PUBLICLY-26114720, KAKENHI-PROJECT-26253084, KAKENHI-PROJECT-26293109, KAKENHI-PROJECT-15K11016, KAKENHI-PROJECT-15K11048, KAKENHI-PROJECT-15K20364, KAKENHI-PROJECT-26670811, KAKENHI-PROJECT-26290040, KAKENHI-PROJECT-26221310
  • [Journal Article] Overexpression of Galnt3 in Chondrocytes Resulted in Dwarfism Due to the Increase of Mucin Type O-glycans and Reduction of Glycosaminoglycans.2014

    • Author(s)
      Yoshida CA, Kawane T, Moriishi T, Purushothaman A, Miyazaki T, Komori H, Mori M, Qin X, Hashimoto A, Sugahara K, Yamana K, Takada K, Komori T.
    • Journal Title

      The Journal of biological chemistry

      Volume: 289 Issue: 38 Pages: 26584-26596

    • DOI

      10.1074/jbc.m114.555987

    • NAID

      120005906910

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26670811, KAKENHI-PROJECT-26221310
  • [Journal Article] Dlx5 and Mef2 Regulate a Novel Runx2 Enhancer for Osteoblast-Specific Expression.2014

    • Author(s)
      Kawane T, Komori H, Liu W, Moriishi T, Miyazaki T, Mori M, Matsuo Y, Takada Y, Izumi S, Jiang Q, Nishimura R, Kawai Y, Komori T.
    • Journal Title

      Journal of bone and mineral research

      Volume: - Issue: 9 Pages: 1960-1969

    • DOI

      10.1002/jbmr.2240

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249062, KAKENHI-PROJECT-24659829, KAKENHI-PROJECT-25293378, KAKENHI-PROJECT-26253084, KAKENHI-PROJECT-26221310
  • [Journal Article] Identification of the promoter region of the parathyroid hormone receptor gene responsible for transcriptional suppression by insulin-like growth factor-I.2005

    • Author(s)
      Tetsuya Kawane
    • Journal Title

      Archives of Biochemistry and Biophysics 439

      Pages: 61-69

    • Data Source
      KAKENHI-PROJECT-17591948
  • [Journal Article] Identification of the promoter region of the parathyroid hormone receptor gene responsible for transcriptional suppression by insulin-like growth factor-I2005

    • Author(s)
      Tetsuya Kawane
    • Journal Title

      Archives of Biochemistry and Biophysics (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15592130
  • [Journal Article] Identification of the promoter region of the parathyroid Hormone receptor gene responsible for transcriptional suppression by insulin-like growth factor-I.2005

    • Author(s)
      Tetsuya Kawane, Junsei Mimura, Yoshiaki Fujii-Kuriyama, Noboru Horiuchi
    • Journal Title

      Archives of Biochemistry and Biophysics in press

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591976
  • [Journal Article] Identification of the promoter region of the parathyroid hormone receptor gene responsible for transcriptional suppression by insulin-like growth factor-I2005

    • Author(s)
      Tetsuya Kawane
    • Journal Title

      Archives of Biochemistry and Biophysics (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591976
  • [Journal Article] Identification of the promoter region of the parathyroid hormone receptor gene responsible for transcriptional suppression by insulin-like growth factor-I2005

    • Author(s)
      Tetsuya Kawane
    • Journal Title

      Archives of Biochemistry and Biophysics in press

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15592130
  • [Journal Article] Atorvastatin enhances bone density in ovariectomized rats given 17β-estradiol or human parathyroid hormone (1-34).2004

    • Author(s)
      Tetsuya Kawane
    • Journal Title

      Endocrine 24・2

      Pages: 121-129

    • Data Source
      KAKENHI-PROJECT-15591976
  • [Journal Article] Atorvastatin enhances hone density in ovariectomized rats given 17j3-estradiol or human parathyroid hormone (1-34).2004

    • Author(s)
      Tetsuya Kawane, Shinichi Terashima, Izuru Kurahashi, Toru Yanagawa, Hiroshi Yoshida, Noboru Horiuchi
    • Journal Title

      Endocrine 24-2

      Pages: 121-129

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591976
  • [Journal Article] Atorvastatin enhances bone density in ovariectomized rats given 17β-estradiol or human parathyroid hormone(1-34)2004

    • Author(s)
      Tetsuya Kawane
    • Journal Title

      Endocrine 24・2

      Pages: 121-129

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591976
  • [Journal Article] Effect of leptin on renal lα-chydroxylase expression in mice.2004

    • Author(s)
      Noboru Horiuchi, Ayako Matsunuma, Toyonobu Maeda, Masatoshi Abe, Testuya Kawane
    • Journal Title

      Proceedings of 12th International Congress of Endocrinology.

      Pages: 1153-1157

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591976
  • [Journal Article] Atorvastatin enhances bone density in ovariectomized rats given 17β- estradiol or human parathyroid hormone (1-34).2004

    • Author(s)
      Tetsuya Kawane
    • Journal Title

      Endocrine 24(2)

      Pages: 121-129

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15592130
  • [Journal Article] Atorvastatin enhances bone density in ovariectomizec rats given 17β-estradiol or human parathyroid hormone (1-34).2004

    • Author(s)
      Tetsuya Kawane
    • Journal Title

      Endocrine 24・2

      Pages: 121-129

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15592130
  • [Journal Article] Atorvastatin enhances bone density in ovariectomized rats given 17β-estradiol or human parathyroid hormone(1-34).2004

    • Author(s)
      Tetsuya Kawane
    • Journal Title

      Endocrine 24・2

      Pages: 121-129

    • Data Source
      KAKENHI-PROJECT-15592130
  • [Journal Article] Leptin corrects increased gene expression of renal 25-hydroxyvitamin D_3- lα-hydroxylase and -24-hydroxylase in leptin- deficient, ob/ob mice.2004

    • Author(s)
      Ayako Matsunuma, Tetsuya Kawane, Toyonobu Maeda, Setsuo Hamada, Noboru Horiuchi
    • Journal Title

      Endocrinology 145-3

      Pages: 1367-1375

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591976
  • [Journal Article] Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation.2003

    • Author(s)
      Toyonobu Maeda, Tetsuya Kawane, Noboru Horiuchi
    • Journal Title

      Endocrinology 144-2

      Pages: 681-692

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591976
  • [Journal Article] Effect of low calcium diet on parathyroid hormone receptor gene expression.2003

    • Author(s)
      Tetsuya Kawane
    • Journal Title

      Ohu University Dental Journal 30(2)

      Pages: 163-167

    • NAID

      110000994060

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15592130
  • [Journal Article] 副甲状腺ホルモン受容体遺伝子発現に対する低カルシウム食飼育の影響2003

    • Author(s)
      川根徹也
    • Journal Title

      奥羽大学歯学誌 30・2

      Pages: 163-167

    • NAID

      110000994060

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15592130
  • [Journal Article] Parathyroid hormone (PTH) down-regulates PTH/PTH-related protein reeptor gene expression in UMR-106 osteoblast-like cells via a 3', 5'-cyclic adenosine monophosphate- dependent, protein kinase A-independent pathway.2003

    • Author(s)
      Tetsuya Kawane, Junsei Mimura, Toru Yanagawa, Yoshiaki Fujii-Kuriyama, Noboru Horiuchi
    • Journal Title

      Journal of Endocrinology 178

      Pages: 247-256

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591976
  • [Presentation] Cbfb plays important roles in bone development through the stabilization of Run family proteins.2015

    • Author(s)
      Qin X,Jiang Q,Matsuo Y,Kawane T,Komori H,Moriishi T,Taniuchi I, Ito K,Kawai Y,Rokutanda S,Izumi S, Komori T.
    • Organizer
      The RUNXTranscription Factors in Development and Disease
    • Place of Presentation
      Weizmann Institude of Science,Rehovot,Israel
    • Year and Date
      2015-10-18
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26221310
  • [Presentation] 軟骨細胞におけるGlant3の過剰発現はムチン型O-グリカンを増加させグリコサミノグリカンを減少させることによってdwarfismを起こす2015

    • Author(s)
      川根徹也、森石武史、小守寿人、小守壽文
    • Organizer
      第33回日本骨代謝学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-07-23
    • Data Source
      KAKENHI-PROJECT-26221310
  • [Presentation] 軟骨細胞におけるGalnt3の過剰発現はムチン型O-グリカンを増加させグリコサミノグリカンを減少させることによってdwarfismを引き起こす2015

    • Author(s)
      川根徹也, 森石武史, 小守寿人, 小守壽文
    • Organizer
      日本骨代謝学会
    • Place of Presentation
      京王プラザホテル(東京都・新宿区)
    • Year and Date
      2015-07-23
    • Data Source
      KAKENHI-PROJECT-15K11048
  • [Presentation] Runx2遺伝子の骨芽細胞特異的発現制御機構2014

    • Author(s)
      小守 寿人、川根 哲也、森石 武史、高田 美生、小守 壽文
    • Organizer
      第32回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場、大阪府大阪市
    • Year and Date
      2014-07-24
    • Data Source
      KAKENHI-PROJECT-26221310
  • [Presentation] Runx2遺伝子の骨芽細胞特異的発現制御機構

    • Author(s)
      小守 寿人、川根 徹也、森石 武史、高田 美生、小守 壽文
    • Organizer
      第32回日本骨代謝学会学術集会
    • Place of Presentation
      大阪市 大阪国際会議場
    • Year and Date
      2014-07-24 – 2014-07-26
    • Data Source
      KAKENHI-PROJECT-26253084
  • 1.  KOMORI Toshihisa (00252677)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 11 results
  • 2.  MIYAZAKI Toshihiro (10174161)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 1 results
  • 3.  MORIISHI Takeshi (20380983)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 7 results
  • 4.  HORIUCHI Noboru (00107294)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 6 results
  • 5.  MATSUNUMA Ayako (30296040)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 6.  ABE Masatoshi (10254872)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 7.  増山 律子 (60297596)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  YANAGAWA Tohru (10312852)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  KURAHASHI Izuni (40337259)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  MAEDA Toyonobu (10382756)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  明野 ながこ (30231856)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  馬場 友巳 (60189727)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  姜 晴 (00790007)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  松尾 友紀 (40792601)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  ROKUTANDA Satoshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

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