HIGUCHI Toshihiro 樋口壽宏

Researcher Number	00283614
Other IDs
Affiliation *help	2016 – 2018 : 京都大学, 医学研究科, 非常勤講師 2005 – 2006 : 京都大学, 医学研究科, 講師 1997 – 2005 : 京都大学, 医学研究科, 助手
Review Section/Research Field	Principal Investigator Obstetrics and gynecology / Obstetrics and gynecology Except Principal Investigator Obstetrics and gynecology / Obstetrics and gynecology
Keywords	Principal Investigator 着床 / implantation / 浸潤 / ケモカイン / DPP-IV / Trophoblast / ephrin / 不妊症 / 胎盤形成 / 絨毛 … More Except Principal Investigator 着床 / 胚 / hCG / 子宮内膜 / 末梢血単核球 / embryo / Eph-ephrin / 妊娠 / DNA array / 不妊症 / 子宮内膜間質細胞 / 免疫細胞 / peripheral blood mononuclear cells / 子宮内膜症 / LIF / implantation failure / Endometrium / マウス / 婦人科癌 / 体外受精-胚移植法 / immune cells / implantation / 浸潤 / 子宮内膜上皮細胞 / 免疫療法 / 着床障害 / endometrial epithelial cells / 免疫担当細胞 / IL-8 / crosstalk / IL-2 / adhesion molecule / CD25^+CD4^+T細胞 / BDNF / 黄体 / Lukemia Inhibitory Factor / ES細胞 / 肥満細胞 / helper T細胞 / 腫瘍免疫 / Embryo / 制御性T細胞 / 免疫抑制 / テーラーメード医療 / ヒスタミン / LAK細胞 / 脱落膜化 / 低酸素 / 糖鎖 / 子宮内膜基底層 / CD25^+CD4^+制御性T細胞 / Peripheral blood mononuclear cell / Extravillous trophoblast / IVF-ET / 末梢血 / 感受性試験 / HB-EGF / HCG / Implantation window / Immune cells / Peripheral bllod / BeWo細胞 / Corpus luteum / 着床不全 / Corpus luteum of pregnancy / endometrial stromal cells / pregnancy / NK / leukemia inhibitory factor / 妊娠黄体 / サブトラクション法 / 接着分子 / BeWo cell / Membrane-bound peptidase / 免疫学的拒絶 / endometrium / 単クローン抗体 / splenocyte / Implantation / ケモカイン / 細胞培養 / 栄養膜幹細胞 / GITR / 増殖能 / 単クローン抗体法 / 培養液 / 末梢血免疫細胞 / 黄体機能不全 / エフェクターT細胞 / 抹消血 / 絨毛外栄養膜細胞 / 抹消血単核球 / 接着阻害分子 / 細胞膜結合型peptidase. / invasion / 胚盤胞 / リンパ球 / attachment inhibitory factors / モノクローナル抗体 / クロストーク / 細胞膜結合型peptidase / endometriosis / 浸潤機構 / 線維芽細胞 Less

着床期マウス子宮内膜に分布する肥満細胞の機能に関する検討
- Principal Investigator
  
  高倉賢二
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
Analyses of the influence of maternal stress on the implantation of mouse embryoPrincipal Investigator
- Principal Investigator
  
  HIGUCHI Toshihiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  KYOTO UNIVERSITY
患者個人の癌細胞を用いたテーラーメイド医療の確立のための基礎的検討
- Principal Investigator
  
  FUJII Shingo
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
HCGホルモンの糖鎖を利用した霊長類の生殖戦略の解析-レクチンによる末梢血免疫細胞の母体血管機能制御機構-
- Principal Investigator
  
  藤原浩
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
Molecular biological analysis of mechanisms for human embryo implantation and placentation-from the perspectrives of repulsive force, chemoattractants and membrane-bound peptidases
- Principal Investigator
  
  FUJIWARA Hiroshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  KYOTO UNIVERSITY
難治性婦人科悪性腫瘍に対する新しい免疫療法の開発を目指して
- Principal Investigator
  
  刈谷方俊
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
サル栄養膜幹細胞を用いた免疫寛容性生体膜の開発に関する基礎検討 -再生医学および細胞移植への臨床応用を目指して-
- Principal Investigator
  
  YOSHIOKA Shinya
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
Analysis and identifying adhesion molecules on endometrial epithelial cells that induce and activate embryo
- Principal Investigator
  
  KOSAKA Kenzo, 巽啓司
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  KYOTO UNIVERSITY
Analyses of regulation mechanisms which induce invasion of human extravillous troophoblasts toward maternal uterine spiral arteries.Principal Investigator
- Principal Investigator
  
  HIGUCHI Toshihiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  KYOTO UNIVERSITY
Analysis of crosstalk between embryo and mother through circulation system
- Principal Investigator
  
  FUJIWARA Hiroshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  KYOTO UNIVERSITY
Study on new therapy for infertile patients suffering from implantation failure
- Principal Investigator
  
  FUJIWARA Hiroshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
Study on the regulatory mechanism of differentiation and invasive ability of human endometrial stromal cells
- Principal Investigator
  
  TATSUMI Keiji
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  KYOTO UNIVERSITY
Role of molecules expressed in human extravillous trophoblasts on the regulatory mechanism of cancer invasionPrincipal Investigator
- Principal Investigator
  
  HIGUCHI Toshihiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
マウス着床モデルを用いた免疫系細胞による胚着床促進機構の解析
- Principal Investigator
  
  NAKAYAMA Takahiro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
ヒト子宮内膜間質細胞の浸潤モデルを用いた子宮内膜症の進展機序の解析
- Principal Investigator
  
  藤原浩
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
Analysis of differentiation mechanisms from human corpus luteum of menstrual cycle to corpus luteum of pregnancy - new differention mechanism through immune system -
- Principal Investigator
  
  FUJIWARA Hiroshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
Investigation of controlled human extravillous trophoblast invasionPrincipal Investigator
- Principal Investigator
  
  HIGUCHI Toshihiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  KYOTO UNIVERSITY (C)(2)
Approach to develop a new treatment for patients with implantationfailure using peripheral blood mononuclear cells
- Principal Investigator
  
  NAKAYAMA Takahiro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  KYOTO UNIVERSITY
Identification of uterine genes induced by embryo during mice implantation.Principal Investigator
- Principal Investigator
  
  HIGUCHI Toshihiro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  KYOTO UNIVERSITY

All 2004 2003

All Journal Article

[Journal Article] Human extravillous trophoblasts express laeverin, a novel protein that belongs to membrane-bound gluzincin metallopeptidases.2004
- Author(s)
  Fujiwara H, Higuchi T, Yamada S, Hirano T, Sato Y, Nishioka Y, Yoshioka S, Tatsumi K, Ueda M, Maeda M, Fujii S.
- Journal Title
  
  Biochem Biophys Res Commun. 23;313(4)
  
  Pages : 962-968
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591743
[Journal Article] Cyclic AMP enhances the expression of an extravillous trophoblast marker, melanoma cell adhesionmolecule, in choriocarcinoma cell JEG3 and human chorionic villous explant cultures.2003
- Author(s)
  Higuchi T et al.
- Journal Title
  
  Mol Hum Reprod 9(6)
  
  Pages : 359-366
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591744
[Journal Article] Cyclic AMP enhances the expression of an extravillous trophoblast marker, melanoma cell adhesion molecule, in choriocarcinoma cell JEG3 and human chorionic villous explant cultures.2003
- Author(s)
  Higuchi T, Fujiwara H, Egawa H, Sato Y, Yoshioka S, Tatsumi K, Itoh K, Maeda M, Fujita J, Fujii S.
- Journal Title
  
  Mol Hum Reprod. 9(6)
  
  Pages : 359-366
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591743
[Journal Article] Cyclic AMP enhances the expression of an extravillous trophoblast marker, Melanoma cell adhesion molecule, in choriocarcinoma cell JEG3 and human chorionic villous explant cultures2003
- Author(s)
  Higuchi, T
- Journal Title
  
  Molecular Human Reproduction 9(6)
  
  Pages : 359-366
- Data Source
  KAKENHI-PROJECT-15591743
[Journal Article] Cyclic AMP enhances the expression of an extravillous trophoblast marker, melanoma cell adhesion molecule, in choriocarcinoma cell JEG3 and human chorionic villous explant cultures2003
- Author(s)
  Higuchi, T.
- Journal Title
  
  Mol Hum Reprod. 9(6)
  
  Pages : 359-366
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591743
[Journal Article] Ephrin B1 is expressed on human luteinizing granulosa cells in corpora lutea of the early luteal phase : the possible involvement of the B class Eph-ephrin system during corpus luteum formation.2003
- Author(s)
  Egawa M, Yoshioka S, Higuchi T, Sato Y, Tatsumi K, Fujiwara H, Fujii S.
- Journal Title
  
  J Clin Endocrinol Metab. 88(9)
  
  Pages : 4384-4392
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591743
[Journal Article] Human peripheral blood mononuclear cells enhance cell-cell interaction between human endometrial epithelial cells and BeWo-cell spheroids.2003
- Author(s)
  Kosaka K, Fujiwara H, Tatsumi K, Yoshioka S, Higuchi T, Sato Y, Nakayama T, Fujii S
- Journal Title
  
  Hum Reprod. 18(1)
  
  Pages : 19-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591743
[Journal Article] Human blastocysts and endometrial epithelial cells express activated leukocyte cell adhesion molecule (ALCAM/CD166).2003
- Author(s)
  Fujiwara H, Tatsumi K, Kosaka K, Sato Y, Higuchi T, Yoshioka S, Maeda M, Ueda M, Fujii S.
- Journal Title
  
  J Clin Endocrinol Metab. 88(7)
  
  Pages : 3437-3443
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591743
[Journal Article] Cyclic AMP enhances the expression of an extravillous trophoblast marker, melanoma cell adhesion molecule, in choriocarcinoma cell JEG3 and human chorionic villous explant cultures.2003
- Author(s)
  Higuchi T
- Journal Title
  
  Mol Hum Reprod 9・(6)
  
  Pages : 359-366
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591744

1. FUJIWARA Toshihiro (30252456)

# of Collaborated Projects : 12results

# of Collaborated Products : 5results
2. YOSHIOKA Shinya (90333575)

# of Collaborated Projects : 7results

# of Collaborated Products : 5results
3. FUJITA Jun (50173430)

# of Collaborated Projects : 7results

# of Collaborated Products : 0results
4. FUJII Shingo (30135579)

# of Collaborated Projects : 6results

# of Collaborated Products : 0results
5. TAKAKURA Kenji (10221350)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
6. KOSAKA Kenzo (90359828)

# of Collaborated Projects : 3results

# of Collaborated Products : 2results
7. TATSUMI Keiji (10324633)

# of Collaborated Projects : 3results

# of Collaborated Products : 5results
8. NAKAYAMA Takahiro (70273448)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
9. FUKUHARA Ken (00362533)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
10. 刈谷方俊 (90243013)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
11. MAEDA Michiyuki (20027329)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
12. NAKATSUJI Norio (80237312)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. NISHI Eiichirou (30362528)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
14. 井上卓也 (90283598)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
15. 伊東宏晃 (70263085)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

HIGUCHI Toshihiro 樋口 壽宏

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Analyses of the influence of maternal stress on the implantation of mouse embryoPrincipal Investigator

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Analyses of regulation mechanisms which induce invasion of human extravillous troophoblasts toward maternal uterine spiral arteries.Principal Investigator

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Role of molecules expressed in human extravillous trophoblasts on the regulatory mechanism of cancer invasionPrincipal Investigator

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HIGUCHI Toshihiro 樋口壽宏