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TAKAHASHI MINORU  高橋 実

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TAKAHASHI Minoru  高橋 実

高橋 実  タカハシ ミノル

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Researcher Number 00285024
Other IDs
Affiliation (Current) 2025: 福島県立医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2014 – 2015: 福島県立医科大学, 医学部, 准教授
2012 – 2013: 福島県立医科大学, 医学部, 講師
2011: 福島県立医科大学, 医学部, 助教
2005 – 2006: 福島県立医科大学, 医学部, 助手
1999 – 2002: 福島県立医科大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Pathological medical chemistry / Pathological medical chemistry / General medical chemistry / Immunology
Except Principal Investigator
Biological Sciences / Collagenous pathology/Allergology / Immunology / General surgery
Keywords
Principal Investigator
MASP / 補体 / レクチン経路 / 自然免疫 / 3MC症候群 / 遺伝子改変マウス / トランスジェニック / ノックアウトマウス / MASP欠損マウス / バキュロウイルス / 生体防御 / 分子生物学 … More
Except Principal Investigator
… More MASP / 補体 / 自然免疫 / レクチン / レクチン経路 / Ficolin / 分子進化 / フィコリン / ジーンターゲッティング / MBL / MAp44 / MASP-1/3 / 第二経路 / Molecular Evolution / Lectin Pathway / Complement / Gene targeting / Lectin pathway / complement / Host defeuse / Lectin / 遺伝子改変マウス / 生体防御 / ficolin / セリンプロテアーゼ / デンマーク / 国際研究者交流 / ノックアウトマウス / MHCクラスI / アロ認識 / 移植免疫 / 腫瘍特異的ペプチド / テトラマー / CTL / MHC Less
  • Research Projects

    (11 results)
  • Research Products

    (36 results)
  • Co-Researchers

    (11 People)
  •  3MC症候群の病態への補体関連因子MASP-1/3の関与とその分子機構の研究Principal Investigator

    • Principal Investigator
      高橋 実
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Fukushima Medical University
  •  Development of complement component MASP-1/3 inhibitors for treatment of lupus animal models.

    • Principal Investigator
      SEKINE Hideharu
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Collagenous pathology/Allergology
    • Research Institution
      Fukushima Medical University
  •  Investigation for complement D factor activation by MASP-1/3Principal Investigator

    • Principal Investigator
      TAKAHASHI Minoru
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Fukushima Medical University
  •  MASP欠損マウスを用いた病原微生物に対する感受性の検討Principal Investigator

    • Principal Investigator
      高橋 実
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Immunology
    • Research Institution
      Fukushima Medical University
  •  補体レクチン経路の自然免疫における役割と活性化機構

    • Principal Investigator
      松下 操
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokai University
  •  補体レクチン経路の自然免疫における役割と活性化機構

    • Principal Investigator
      MATSUSHITA Misao
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Fukushima Medical University
  •  Masp1欠損マウスを用いたレクチン経路の解析と敗血症ショックの発症機構Principal Investigator

    • Principal Investigator
      高橋 実
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Fukushima Medical University
  •  Roles of host defense lectin.s in innate immunity

    • Principal Investigator
      FUJITA Teizo
    • Project Period (FY)
      2001 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      UNIVERCTTY
  •  MHCクラスIテトラマーを用いた同種移植における拒絶反応の解析

    • Principal Investigator
      FUJITA Teizo, 見城 明
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      General surgery
    • Research Institution
      Fukushima Medical University
  •  Molecular basis of complement activation by ficolins throu the lectin pathsay

    • Principal Investigator
      FUJITA Teizo
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Fukushima Medical University School of Medicine
  •  Masp欠損マウスを用いた生体防御における補体レクチン経路の役割Principal Investigator

    • Principal Investigator
      高橋 実
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Fukushima Medical University

All 2015 2014 2013 2012 2011 2006

All Journal Article Presentation

  • [Journal Article] C3 dysregulation due to factor H deficiency is mannan-binding lectin-associated serine proteases (MASP)-1, MASP-3 independent in vivo2014

    • Author(s)
      Ruseva M. M., Takahashi M., Fujita T., Pickering M. C.
    • Journal Title

      Clin Exp Immunol

      Volume: 176 Pages: 84-92

    • Data Source
      KAKENHI-PROJECT-23590342
  • [Journal Article] Essential role for the lectin pathway in collagen antibody-induced arthritis revealed through use of adenovirus programming complement inhibitor MAp44 expression.2014

    • Author(s)
      Banda NK1, Mehta G2, Kjaer TR3, Takahashi M4, Schaack J5, Morrison TE5, Thiel S3, Arend WP2, Holers VM1.
    • Journal Title

      J Immunol

      Volume: 193 Issue: 5 Pages: 2455-2468

    • DOI

      10.4049/jimmunol.1400752

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26460393
  • [Journal Article] Lessons learned from mice deficient in lectin complement pathway molecules.2014

    • Author(s)
      Genster N, Takahashi M, Sekine H, Endo Y, Garred P, Fujita T
    • Journal Title

      Mol Immunol

      Volume: 61 Issue: 2 Pages: 59-68

    • DOI

      10.1016/j.molimm.2014.07.007

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25460596, KAKENHI-PROJECT-26460393
  • [Journal Article] Comment on "the pro-factor D cleaving activity of MASP-1/-3 is not required for alternative pathway function".2014

    • Author(s)
      Takahashi M1, Sekine H2, Fujita T2
    • Journal Title

      J Immunol

      Volume: 192 Issue: 12 Pages: 5448-5449

    • DOI

      10.4049/jimmunol.1400766

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26460393
  • [Journal Article] The Role of MASP-1/3 in Complement Activation2013

    • Author(s)
      Sekine H., Takahashi M., Iwaki D., Fujita T.
    • Journal Title

      Adv Exp Med Biol

      Volume: 734 Pages: 41-53

    • Data Source
      KAKENHI-PROJECT-23590342
  • [Journal Article] C3 dysregulation due to factor H deficiency is mannan-binding lectin-associated serine proteases (MASP)-1 and MASP-3 independent in vivo.2013

    • Author(s)
      Ruseva MM, Takahashi M, Fujita T, Pickering MC.
    • Journal Title

      Clin Exp Immunol.

      Volume: 176 Issue: 1 Pages: 84-92

    • DOI

      10.1111/cei.12244

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23590342, KAKENHI-PROJECT-26460393
  • [Journal Article] The role of MASP-1/3 in complement activation.2013

    • Author(s)
      Sekine H, Takahashi M, Iwaki D, Fujita T.
    • Journal Title

      Adv Exp Med Biol

      Volume: 735 Pages: 41-53

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590342
  • [Journal Article] Role of complement in a murine model of peanut-induced anaphylaxis.2013

    • Author(s)
      Kodama T1, Sekine H, Takahashi M, Iwaki D, Machida T, Kanno K, Ishida Y, Endo Y, Fujita T.
    • Journal Title

      Immunobiology

      Volume: 218 Issue: 6 Pages: 844-850

    • DOI

      10.1016/j.imbio.2012.10.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590342, KAKENHI-PROJECT-23591442, KAKENHI-PROJECT-23790542
  • [Journal Article] Role of complement in a murine model of peanut-induced anaphylaxis2013

    • Author(s)
      Kodama T., Sekine H., Takahashi M., Iwaki D., Machida T., Kanno K., Ishida Y., Endo Y., Fujita T.
    • Journal Title

      Immunobiology

      Volume: 218 Pages: 844-850

    • Data Source
      KAKENHI-PROJECT-23590342
  • [Journal Article] Comment on "mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function"2013

    • Author(s)
      Takahashi M, Sekine H, Endo Y, Fujita T.
    • Journal Title

      J Immunol.

      Volume: 190 Issue: 6 Pages: 2477-2477

    • DOI

      10.4049/jimmunol.1390002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590342, KAKENHI-PROJECT-23591442, KAKENHI-PROJECT-25460596
  • [Journal Article] Comment on "Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function"2013

    • Author(s)
      Takahashi M., Sekine H., Endo Y., Fujita T.
    • Journal Title

      J Immunol

      Volume: 190 Pages: 2477-2477

    • Data Source
      KAKENHI-PROJECT-23590342
  • [Journal Article] Mouse ficolin B has an ability to form complexes with mannose-binding lectin-associated serine proteases and activate complement through the lectin pathway.2012

    • Author(s)
      Endo Y, Iwaki D, Ishida Y, Takahashi M, Matsushita M, Fujita T.
    • Journal Title

      J Biomed Biotech

      Volume: 2012 Pages: 105891-105891

    • DOI

      10.1155/2012/105891

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22570144, KAKENHI-PROJECT-23590342
  • [Journal Article] Mannose-binding lectin-associated serine protease-1 is a significant contributor to coagulation in a murine model of occlusive thrombosis2012

    • Author(s)
      La Bonte L. R., Pavlov V. I., Tan Y. S., Takahashi K., Takahashi M., Banda N. K., Zou C., Fujita T., Stahl G. L.
    • Journal Title

      J Immunol

      Volume: 188 Pages: 885-891

    • Data Source
      KAKENHI-PROJECT-23590342
  • [Journal Article] Mannose-binding lectin-associated serine protease-1 is a significant contributor to coagulation in a murine model of occlusive thrombosis2012

    • Author(s)
      La Bonte LR, et al
    • Journal Title

      J Immunol

      Volume: 188(2) Issue: 2 Pages: 885-91

    • DOI

      10.4049/jimmunol.1102916

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390086, KAKENHI-PROJECT-23590342
  • [Journal Article] Mouse ficolin B Has an ability to form complexes with mannose-binding lectin-associated serine proteases, activate complement through the lectin pathway2012

    • Author(s)
      Endo Y., Iwaki D., Ishida Y., Takahashi M., Matsushita M., Fujita T.
    • Journal Title

      Journal of biomedicine & biotechnology

      Volume: 2012 Pages: 105891-105891

    • Data Source
      KAKENHI-PROJECT-23590342
  • [Journal Article] 補体D因子の活性化とMASP-12011

    • Author(s)
      高橋 実
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 56 Pages: 78-83

    • NAID

      40018938414

    • Data Source
      KAKENHI-PROJECT-23590342
  • [Journal Article] Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation2011

    • Author(s)
      Takahashi, K. Chang, W. C. Takahashi, M. Pavlov, V. Ishida, Y. La Bonte, L. Shi, L. Fujita, T. Stahl, G. L. Van Cott, E. M.
    • Journal Title

      Immunobiology

      Volume: 216 Issue: 1-2 Pages: 96-102

    • DOI

      10.1016/j.imbio.2010.02.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590342
  • [Journal Article] 補体D因子の活性化とMASP-12011

    • Author(s)
      高橋実
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 56 Pages: 78-83

    • NAID

      40018938414

    • Data Source
      KAKENHI-PROJECT-23590342
  • [Journal Article] Mannose-binding lectin, its associated proteases (MASPs) mediate coagulation, its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation2011

    • Author(s)
      Takahashi K., Chang W. C., Takahashi M., Pavlov V., Ishida Y., La Bonte L., Shi L., Fujita T., Stahl G. L., Van Cott E. M.
    • Journal Title

      Immunobiology

      Volume: 216 Pages: 96-102

    • Data Source
      KAKENHI-PROJECT-23590342
  • [Journal Article] The Role of Mannose-Binding Lectin-Associated Serine Protease-3 in Activation of the Alternative Complement Pathway2011

    • Author(s)
      Iwaki D., Kanno K., Takahashi M., Endo Y., Matsushita M., Fujita T.
    • Journal Title

      The Journal of Immunology

      Volume: 187 Pages: 3751-3758

    • Data Source
      KAKENHI-PROJECT-23590342
  • [Journal Article] Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement2011

    • Author(s)
      Banda NK, et al
    • Journal Title

      Mol Immunol

      Volume: 49(1-2) Issue: 1-2 Pages: 281-9

    • DOI

      10.1016/j.molimm.2011.08.021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390086, KAKENHI-PROJECT-23590342
  • [Journal Article] Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement2011

    • Author(s)
      Banda N. K., Takahashi M., Takahashi K., Stahl G. L., Hyatt S., Glogowska M., Wiles T. A., Endo Y., Fujita T., Michael Holers V., Arend W. P.
    • Journal Title

      Mol Immunol

      Volume: 49 Pages: 281-289

    • Data Source
      KAKENHI-PROJECT-23590342
  • [Journal Article] Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial, gastrointestinal ischemia/reperfusion injury2011

    • Author(s)
      Schwaeble W. J., Lynch N. J., Clark J. E., Marber M., Samani N. J., Ali Y. M., Dudler T., Parent B., Lhotta K., Wallis R., Farrar C. A., Sacks S., Lee H., Zhang M., Iwaki D., Takahashi M., Fujita T., Tedford C. E., Stover C. M.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 108 Pages: 7523-7528

    • Data Source
      KAKENHI-PROJECT-23590342
  • [Journal Article] Cloning and characterization of mannose-binding lectin from lamprey(Agnathans).2006

    • Author(s)
      Takahashi, M. et al.
    • Journal Title

      J. Immunol. 176

      Pages: 4861-4868

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13143204
  • [Journal Article] Cloning and characterization of mannose-binding lectin from lamprey (Agnathans).2006

    • Author(s)
      Takahashi, M. et al.
    • Journal Title

      J. Immunol. 176

      Pages: 4861-4868

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13143204
  • [Journal Article] Cloning and Characterization of Mannose-Binding Lectin from Lamprey (Agnathans).2006

    • Author(s)
      Takahashi, M.et al.
    • Journal Title

      J Immunol. (in press)

    • Data Source
      KAKENHI-PROJECT-13143204
  • [Presentation] Upregulation of Complement C3 and Alpha-2-Macroglobulin in Cerebrospinal Fluid of Neuropsychiatric Systemic Lupus Erythematosus2015

    • Author(s)
      Tomoyuki Asano, Shuzo Sato, Hiroko Kobayashi, Yoshinobu Kariya, Hiromi Ito, Kyoka Hoshi, Akioh Yoshihara, Yoshikazu Ugawa, Minoru Takahashi, Hideharu Sekine, Shunsei Hirohata, Hiroshi Watanabe, Hiromasa Ohira and Yasuhiro Hashimoto
    • Organizer
      2015-Annual Scientific Meeting of the American College of Rheumatology
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2015-11-08
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670478
  • [Presentation] マウス型リコンビナントタンパクrmMAp44-PA, rmMAp44-Igの作製と補体レクチン経路の阻害作用2015

    • Author(s)
      高住美佳、高橋実、大森智子、町田豪、坂本夏美、石田由美、関根英治
    • Organizer
      日本補体学会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2015-08-21
    • Data Source
      KAKENHI-PROJECT-26670478
  • [Presentation] 補体因子MASP-1/3欠損のMRL/lprマウスでは補体第二経路の活性化が抑制され、糸球体腎炎が改善される2015

    • Author(s)
      坂本夏美、町田豪、高橋実、関根英治
    • Organizer
      Rheumatology Conference 2015
    • Place of Presentation
      東京都中央区
    • Year and Date
      2015-06-06
    • Data Source
      KAKENHI-PROJECT-26670478
  • [Presentation] MASP-1 および MASP-3 の機能-ヒトとマウスの違いについて2013

    • Author(s)
      高橋実、遠藤雄一、Alexandra Antonioli、V Michael Holers、 Wilhelm Schwaeble、 藤田禎三、関根英治
    • Organizer
      第50回補体シンポジウム
    • Place of Presentation
      旭川市
    • Data Source
      KAKENHI-PROJECT-23590342
  • [Presentation] MASP-1およびMASP-3の機能―ヒトとマウスの違いについて2013

    • Author(s)
      高橋実, 遠藤雄一, Alexandra Antonioli, Wilhelm Schwaeble, 藤田禎三, 関根英治
    • Organizer
      補体シンポジウム
    • Place of Presentation
      旭川市
    • Data Source
      KAKENHI-PROJECT-23590342
  • [Presentation] Developmental abnormalities in Masp1/3-deficient mice2012

    • Author(s)
      Minoru Takahashi, Yuichi Endo, Teizo Fujita
    • Organizer
      XXIV. International Complement Workshop
    • Place of Presentation
      Chania, Crete, Greece
    • Data Source
      KAKENHI-PROJECT-23590342
  • [Presentation] MASP1/3欠損マウスにおける形態異常・3MC症候群との関連2012

    • Author(s)
      高橋実, 関根英治, 遠藤雄一, 藤田禎三
    • Organizer
      補体シンポジウム
    • Place of Presentation
      大阪市
    • Data Source
      KAKENHI-PROJECT-23590342
  • [Presentation] Developmental abnormalities in Masp1/3-deficient mice2012

    • Author(s)
      Takahashi M., Yuichi E, Fujita T.
    • Organizer
      XXIV. International Complement Workshop
    • Place of Presentation
      Greece
    • Data Source
      KAKENHI-PROJECT-23590342
  • [Presentation] MASP1遺伝子産物の多様性について2011

    • Author(s)
      高橋実, 岩城大輔, 遠藤雄一, 藤田禎三
    • Organizer
      補体シンポジウム
    • Place of Presentation
      名古屋市
    • Invited
    • Data Source
      KAKENHI-PROJECT-23590342
  • [Presentation] MASP1 遺伝子産物の多機能性について2011

    • Author(s)
      高橋 実 、岩城大輔 、遠藤雄一 、藤田禎三
    • Organizer
      補体シンポジウム(招待講演)
    • Place of Presentation
      名古屋市
    • Data Source
      KAKENHI-PROJECT-23590342
  • 1.  FUJITA Teizo (20134223)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 1 results
  • 2.  MATSUSHITA Misao (00165812)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  ENDO Yuidii (20117427)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 4.  IWAKI Daisuke (10315492)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  NAKATA Munehiro (00266371)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  NAAKMURA Takanori (70183887)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  AZUMI Kaoru (90221720)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  SEKINE Hideharu (40363759)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 9.  MACHIDA TAKESHI (80583632)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 10.  見城 明 (40305355)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  水落 次男 (90133149)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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