Kusuhara Hiroyuki 楠原洋之

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KUSUHARA Hiroyuki 楠原洋之

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Researcher Number	00302612
Other IDs
Affiliation (Current)	2025: 東京大学, 大学院薬学系研究科(薬学部), 教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 東京大学, 大学院薬学系研究科(薬学部), 教授 2012 – 2016: 東京大学, 薬学研究科(研究院), 教授 2014: 東京大学, 大学院薬学系研究科, 教授 2011: The University of Tokyo, 薬学研究科(研究院), 准教授 2007 – 2011: The University of Tokyo, Graduate School of Pharmaceutical Sciences, Professor … More 2006: 東京大学, 大学院薬学系研究科, 助教授 2005: 東京大学, 大学院・薬学系研究科, 助教授 2003 – 2004: 東京大学, 大学院・薬学系研究科, 講師 1998 – 2002: 東京大学, 大学院・薬学系研究科, 助手 2001: 東京大学, 大学院・薬学研究科, 助手 Less
Review Section/Research Field	Principal Investigator Medical pharmacy / Biological Sciences / Basic Section 47060:Clinical pharmacy-related / Complex systems / 応用薬理学・医療系薬学 / Medium-sized Section 47:Pharmaceutical sciences and related fields / Applied pharmacology / Pharmaceutical Sciences and related fields / Science and Engineering Except Principal Investigator Basic Section 90110:Biomedical engineering-related … More / Medical pharmacy / Medium-sized Section 90:Biomedical engineering and related fields / 応用薬理学・医療系薬学 / Biological Sciences / Drug development chemistry / 医薬分子機能学 / Biological pharmacy / Complex systems / Science and Engineering Less
Keywords	Principal Investigator トランスポーター / 薬物動態 / 体内動態 / 薬物間相互作用 / 血液脳関門 / 薬物トランスポーター / 薬物輸送 / 内因性基質 / 代謝物 / 薬物動態学 … More / 腎尿細管分泌 / 尿細管分泌 / 排出輸送 / in vitroモデル / 薬物相互作用 / オミクスデータ / トランスクリプトームデータ / OLSA / プロファイリング / オーファントランスポーター / メタボロミクス解析 / 腎排泄 / 生理学的モデル / 薬剤反応性 / 薬学 / ABCトランスポーター / RST / ベクトル輸送 / 有機アニオントランスポーター / 有機アニオン / 血液脳脊髄液関門 / ヒトモデル / ADME / ヒト予測 / 初代培養細胞 / 薬物代謝 / ヒト由来初代培養細胞 / 代謝物プロファイル解析 / メタボロミクス / 内在性代謝物 / ヒト由来試料 / 初代培養上皮細胞 / 吸収・分泌 / オルガノイド / スフェロイド / 基質探索 / 基質同定 / 膜輸送 / プロファイルデータ解析法 / リート化合物最適化 / リード化合物の最適化 / 天然物 / プロファイルデータ解析 / 潜在的作用 / 構造類似体 / リード化合物最適化 / プロファイル解析 / 薬剤応答性 / ファーマコメタボロミクス / 内在性バイオマーカー / ファーマコメタボローム / 一塩基多型 / 個体間変動 / 内在性基質 / バイオマーカー / 二次元電気泳動 / プロファイル / 薬剤応答 / プロファイルデータ / トランスクリプトーム / 2次元電気泳動 / 併用効果 / 抗がん剤 / プロテオームデータ / レンチウィルス / ライブラリー / CRISPR Cas9システム / ほ乳類細胞 / 遺伝子ノックアウト / CRISPR-Cas9 / 発現抑制 / CRISPR-Cas9システム / sinusoidal efflux / intestine absorption / biliary excretion / tubular secretion / probe drug / drug dispostion / transporter / 肝シヌソイド側排出 / 消化管吸収 / 胆汁排泄 / プローブ薬 / カチオン性薬物 / デリバリー / 組織移行性 / 薬物 / メタボローム解析 / 有機カチオン / 遺伝子多型 / メタボローム / 個人間変動 / 再吸収 / 中枢移行性 / SLCトランスポーター / ＰＥＴ / 代謝酵素 / 階層構造 / スケーリングファクター / 肝異物解毒システム / トランスロケーションモデル / クラスターニュートン法 / cluster newton method / PET / 体内動態予測 / DNAメチル化 / エピジェネティクス / 肝細胞 / 異物解毒 / 分子イメージング / 脳・神経 / 複合体 / 蛋白 / 血液精巣液関門 / 蛋白間相互作用 / トランスポートソーム / 小腸上皮細胞 / 膜電位依存型輸送 / 腎臓 / Oatp1 / プロドラッグ / 薬物速度論 / 再呼吸 / 性差 / Oatp3 / Oat3 / シンクロナイゼーション / 寄与率 / β-lactam系抗生物質 / OAT3 / 脈絡叢 … More Except Principal Investigator トランスポーター / MRP2 / OATP / 薬物動態 / 有機アニオン / 胆汁排泄 / 電気化学 / transporter / OAT / 薬物間相互作用 / 抗がん剤 / 治療薬物モニタリング / 導電性ダイヤモンド電極 / 電気化学センサ / センサ / 癌 / ダイヤモンドセンサ / パゾパニブ / TDM / 分子標的薬 / ダイヤモンド電極 / Mrps / biliary excretion / pharmacophore / OCT / OATP2 / organic anion / MRP / 血液脳関門 / MRP3 / hepatobiliary transport / 肝胆系輸送 / CYP3A4 / 体内動態 / ヒト肝細胞 / 薬剤反応性 / 抗癌薬 / 薬効 / 薬物センサ / 免疫チェックポイント阻害薬 / 導電性ダイヤモンド / ドキソルビシン / 分子鋳型 / ボロンドープダイヤモンド電極 / 分子インプリンティング / 分子インプリント / 薬力学 / フリームービング / 自由行動下 / てんかん / 局所薬物動態 / 針状ダイヤモンドセンサ / 電気化学分析 / 電気化学測定 / イマチニブ / がん薬物療法 / 血中濃度 / ダイヤモンンド電極 / レンバチニブ / 経口分子標的薬 / POCT / バイオセンサ / drug-drue interaction / renal excretion / anti-HIV drugs / diuretics / transporters / metabolic enzymes / SULT / Mrp4 / Mrp3 / 小腸吸収 / 腎排泄 / HIV治療薬 / 利尿薬 / 代謝酵素 / chimeric mice / human hepatocyte / liver uptake / organic anions / liver transport / キメラマウス / 肝取り込み / 肝輸送 / substrate specificity / efflux transport / blood-brain barrier / 基質選択性 / ファーマコフォア / 排出輸送 / biguanides / cerivastatin / drug-drug interaction / OCT2 / OCT1 / ビグアニド系抗糖尿病薬 / セリバスタチン / CAMDAS / blood-CSF barrier / blood-brain barrer / MRP1 / OAT3 / Oatp14 / Oat3 / 排出ポンプ / 3次元構造活性相関 / 血液脳脊髄液関門 / Urinary excretion / Biliary excretion / Organic anion / Transporter / oat3 / oatp1 / 尿中排泄 / detoxification system / gene expression system / species difference / interindividual difference / drug disposition / 遺伝子クローニング / 異物解毒 / 異物解毒機構 / 遺伝子発現系 / 種差 / 個人差 / 生物学 / 生物物理 / 薬物動態学 / 代謝 / 全身循環 / 不整脈 / 心臓 / 生物物理学 / 生理学 / システム生物学 / MATE / 腎スライス / 薬剤感受性 / atorvastatin / 肝クリアランス / 律速段階 / MATEs / シメチジン / ヒト腎スライス / フェノタイピング / クリアランスの律速段階 / 薬物トランスポーター / プローブ薬 / プラバスタチン / オルメサルタン / 生理学的薬物速度論モデル / UGT / テルミサルタン / ゲノム / DNAメチル化 / 遺伝子多型 / 薬学 / 相互作用 / 基質認識 / 能動輸送 Less

Developing a Multimodal Simple Sensor System to Support Personalized Therapy
- Principal Investigator
  
  緒方元気
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Keio University
Development of a prototype of a wearable multimodal sensor subjected to personalized cancer therapy
- Principal Investigator
  
  日比野浩
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Osaka University
Construction of drug transport/metabolism research models by improving functions of human tissue-derived cellsPrincipal Investigator
- Principal Investigator
  
  楠原洋之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  The University of Tokyo
Development of a handy system for rapid drug monitoring from tiny amounts of blood
- Principal Investigator
  
  Ogata Genki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Keio University
Development of an implantable sensory system that can approach safe and effective therapeutic interventions for neuropsychiatric disorders
- Principal Investigator
  
  Hibino Hiroshi
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Osaka University
Pharmacokinetic study on transporters in the xenobiotic detoxification among the liver, small intestine and kidneyPrincipal Investigator
- Principal Investigator
  
  Kusuhara Hiroyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  The University of Tokyo
Development of lead optimization method using novel profile data analysis methodPrincipal Investigator
- Principal Investigator
  
  Kusuhara Hiroyuki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
Development of portable drug concentration measurement system for contributing to a personalized treatment.
- Principal Investigator
  
  OGATA GENKI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Niigata University
Development of deep phenotyping method that enables analysis and application of latent drug responsePrincipal Investigator
- Principal Investigator
  
  Kusuhara Hiroyuki
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Pharmaceutical Sciences and related fields
- Research Institution
  The University of Tokyo
Exploration study to identify pharmacokinetic biomarkers by pharmacometabolomic approachesPrincipal Investigator
- Principal Investigator
  
  Kusuhara Hiroyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  The University of Tokyo
Development of a comprehensive drug transporter identification method by gene knockoutPrincipal Investigator
- Principal Investigator
  
  Kusuhara Hiroyuki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Elucidation of the importance of novel transporters in the disposition of cationic drugsPrincipal Investigator
- Principal Investigator
  
  Kusuhara Hiroyuki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Comprehensive analysis of endogenous compounds applicable to in vivo evaluation of drugs transportersPrincipal Investigator
- Principal Investigator
  
  KUSUHARA Hiroyuki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Comprehensive analysis of the factors regulating the disposition of small molecules at organ and tissue levelsPrincipal Investigator
- Principal Investigator
  
  KUSUHARA Hiroyuki
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
肝異物解毒ネットワークにおける薬物排泄パスウェイの定量的予測方法の開発Principal Investigator
- Principal Investigator
  
  楠原洋之
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
Elucidation of the transporters, and integration research of their molecular entities and activities for the drug transport in the brain and kidneysPrincipal Investigator
- Principal Investigator
  
  KUSUHARA Hiroyuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Establishment of Integrative Multi-level Systems Biology and its Applications
- Principal Investigator
  
  KURACHI YOSHIHISA
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Osaka University
肝特異的トランスポーターの発現変動におけるエピジェネティック制御機構の解析Principal Investigator
- Principal Investigator
  
  楠原洋之
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
異物解毒システムの個人間変動要因に基づいた抗癌剤処方の最適化戦略の開発
- Principal Investigator
  
  杉山雄一
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
薬物動態・薬効の変動に関与する薬物トランスポーターの遺伝子多型の包括的実証研究
- Principal Investigator
  
  杉山雄一
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
薬剤応答性における薬物トランスポートソームの動的制御機構の解明Principal Investigator
- Principal Investigator
  
  楠原洋之
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Development of probe drugs for the evaluation of the functions of drug transporters in vivo in humans
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Development of quantitative evaluation method of the drug transport systems at the blood brain barrier which influences the CNS effect.Principal Investigator
- Principal Investigator
  
  KUSUHARA Hiroyuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
トランスポートソームの機能制御による医薬品体内動態の制御Principal Investigator
- Principal Investigator
  
  楠原洋之
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Establishment of drugs for probing in vivo activity of xenobiotic transporters in humansPrincipal Investigator
- Principal Investigator
  
  KUSUHARA Hiroyuki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Development of the quantitative prediction method of pharmacokinetics with considering the function of metabolic enzymes and transporters
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
抗癌剤のテーラーメード医療確立のための異物解毒システムにおける個人差の解明Principal Investigator
- Principal Investigator
  
  楠原洋之
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
New strategy for the drug development of CNS acting drugs by regulating drug transport across the blood-brain barrier
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Estimation of transport activities in human hepatocyte : analysis using mice with humanized liver
- Principal Investigator
  
  SUZUKI Hiroshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
トランスポーターを介した薬物輸送の予測法の確立:薬効・副作用に関わる組織送達性の定量的制御Principal Investigator
- Principal Investigator
  
  楠原洋之
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  The University of Tokyo
肝・腎トランスポーターによる機能分担と活性調節に関する分子シンクロナイゼーションPrincipal Investigator
- Principal Investigator
  
  楠原洋之
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Drug design based on the substrate specificity of the efflux transporters expressed in the blood-brain barrier
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokyo
Development of the system for prediction of drug-drug interactions in hepatobiliary transport process
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  The University of Tokyo
血液脳関門・血液脳脊髄液関門における能動的薬物排出トランスポータの機能解析:有機アニオントランスポーター(oatp及びoatファミリー)の役割Principal Investigator
- Principal Investigator
  
  楠原洋之
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  The University of Tokyo
肝細胞膜に発現するトランスポーターの分子機能におけるシンクロナイゼーション
- Principal Investigator
  
  KATO Yukio
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Analysis of the factors governing the elimination route of therapeutic agents
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Graduate School of Pharmaceutical Sciences, The University of Tokyo
Role of hepatic transporters in the detoxification
- Principal Investigator
  
  SUGIYAMA Yuichi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Biological pharmacy
- Research Institution
  Graduate School of Pharmaceutical Sciences, The University of Tokyo

[Book] Diamond electrodes : fundamentals and applications　Part 12. In vivo real time measurement of drugs.2022
- Author(s)
  Genki Ogata, Seishiro Sawamura, Kai Asai, Hiroyuki Kusuhara, Yasuaki Einaga, Hiroshi Hibino
- Total Pages
  10
- Publisher
  Springer
- ISBN
  9789811678332
- Data Source
  KAKENHI-PROJECT-21H03805
[Book] Diamond Electrodes2022
- Author(s)
  Genki Ogata, Seishiro Sawamura, Kai Asai, Hiroyuki Kusuhara, Yasuaki Einaga & Hiroshi Hibino
- Total Pages
  248
- Publisher
  Springer, Singapore
- Data Source
  KAKENHI-PROJECT-20K21883
[Book] 臨床薬物動態学（改訂第5版）2017
- Author(s)
  加藤　隆一、家入　一郎、楠原　洋之
- Total Pages
  400
- Publisher
  南江堂
- ISBN
  9784524257584
- Data Source
  KAKENHI-PROJECT-17H04100
[Book] 生物薬剤学 6章1　薬物動態に基づく薬物相互作用2015
- Author(s)
  楠原洋之
- Total Pages
  15
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-26293032
[Book] In vivo characterization of interactions on transporters. In:Transporters in Drug Development2013
- Author(s)
  Kusuhara H, Yoshida K, Sugiyama Y
- Publisher
  Springer
- Data Source
  KAKENHI-PLANNED-23136101
[Book] トランスホーターノックアウトマウスを用いた医薬品体内動態の解析"トランスボートソーム生体膜輸送機構の全体像に迫る"(編集金井好克)2011
- Author(s)
  楠原洋之
- Total Pages
  10
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-20390046
[Book] トランスポートソーム生体膜輸送機構の全体像に迫る(編集金井好克)(トランスポーターノックアウトマウスを用いた医薬品体内動態の解析)2011
- Author(s)
  楠原洋之
- Total Pages
  10
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-20390046
[Book] 薬物動態関連遺伝子多型による薬物動態の変動予測法の開発"創薬技術の革新マイクロドーズからPET分子イメージングへの新展開"(編集杉山雄一、山下伸二、栗原千絵子)2010
- Author(s)
  楠原洋之、前田和哉、杉山雄一
- Total Pages
  10
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-20390046
[Book] 創薬技術の革新マイクロドーズからPET分子イメージングへの新展開(編集杉山雄一、山下伸二、栗原千絵子)(薬物動態関連遺伝子多型による薬物動態の変動予測法の開発)2010
- Author(s)
  楠原洋之、前田和哉、杉山雄一
- Total Pages
  10
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-20390046
[Book] 遺伝子医学Mook12 最新トランスポーター研究2009(血液脳関門・腎尿細管分泌における薬物トランスポーターの役割)2009
- Author(s)
  楠原洋之
- Total Pages
  12
- Data Source
  KAKENHI-PROJECT-20390046
[Book] Drug-drug interactions involving the membrane transport process, Ed.by A.David Rodrigues In:Drug-drug interations 2nd2008
- Author(s)
  Kusuhara H. and Sugiyama Y
- Publisher
  Marcel Dekker
- Data Source
  KAKENHI-PROJECT-18390046
[Book] Drug-drug interactions involving the membrane transport process, Ed.by A.David Rodrigues In:Drug-drug interactions 2nd2008
- Author(s)
  楠原洋之
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-18390046
[Book] Drug-drug interactions involving the membrane transport process, Ed. by A. David Rodrigues In:Drug-drug interactions 2nd2008
- Author(s)
  Kusuhara H. and Sugiyama Y.
- Publisher
  Marcel Dekker
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390046
[Book] 最新創薬学2007 (分担執筆、腎臓における薬物輸送の機能評価)2007
- Author(s)
  楠原洋之
- Publisher
  メディカルドゥ
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390046
[Book] 最新創薬学2007(分担執筆:腎臟におれる薬物輸送の機能評価)2007
- Author(s)
  楠原洋之
- Total Pages
  6
- Publisher
  メディカル・ドゥ
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209005
[Book] 最新創薬学2007(分担執筆、腎臓における薬物輸送の機能評価)2007
- Author(s)
  楠原洋之
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-18390046
[Book] 最新創薬学2007 (分担執筆、腎臓における薬物輸送の機能評価)2007
- Author(s)
  楠原洋之
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-18059007
[Book] 最新創薬学2007(分担執筆:腎臓における薬物輸送の機能評価)2007
- Author(s)
  楠原洋之
- Publisher
  メディカル・ドゥ
- Data Source
  KAKENHI-PROJECT-17209005
[Journal Article] A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced twisted intramolecular charge transfer (sr-TICT)2024
- Author(s)
  Hanaoka Kenjiro、Ikeno Takayuki、Iwaki Shimpei、Deguchi Sayaka、Takayama Kazuo、Mizuguchi Hiroyuki、Tao Fumiya、Kojima Nobuhiko、Ohno Hisashi、Sasaki Eita、Komatsu Toru、Ueno Tasuku、Maeda Kazuya、Kusuhara Hiroyuki、Urano Yasuteru
- Journal Title
  
  Science Advances
  
  Volume: 10 Issue: 7
- DOI
  10.1126/sciadv.adi8847
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-21H05262, KAKENHI-PROJECT-19H05632, KAKENHI-PROJECT-23K23484, KAKENHI-PROJECT-23K27304, KAKENHI-PROJECT-23K27337
[Journal Article] A strategy for low-cost portable monitoring of plasma drug concentrations using a sustainable boron-doped-diamond chip2023
- Author(s)
  Takuro Saiki et al.
- Journal Title
  
  Heliyon
  
  Volume: 9 Issue: 5 Pages: e15963-e15963
- DOI
  10.1016/j.heliyon.2023.e15963
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06695, KAKENHI-PROJECT-21K06421, KAKENHI-PUBLICLY-23H04167, KAKENHI-PROJECT-21H02923, KAKENHI-PROJECT-21H03805
[Journal Article] Impact of Direction of Transport on the Evaluation of Substrate Recognition of Mouse Multidrug and Toxin Extrusion Protein 12023
- Author(s)
  Saito Asami、Kito Tomoko、Ishiguro Naoki、Takatani Masahito、Kudo Takashi、Bister Bojan、Kusuhara Hiroyuki
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 51 Issue: 5 Pages: 583-590
- DOI
  10.1124/dmd.122.001115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03401
[Journal Article] Usefulness of Human Jejunal Spheroid Derived Differentiated Intestinal Epithelial Cells for the Prediction of Intestinal Drug Absorption in Humans2022
- Author(s)
  Michiba Kazuyoshi、Maeda Kazuya、Shimomura Osamu、Miyazaki Yoshihiro、Hashimoto Shinji、Oda Tatsuya、Kusuhara Hiroyuki
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 50 Issue: 3 Pages: 204-213
- DOI
  10.1124/dmd.121.000796
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03401, KAKENHI-PROJECT-20H03402, KAKENHI-PROJECT-20K20467, KAKENHI-PROJECT-23K24172
[Journal Article] A rapid and simple electrochemical detection of the free drug concentration in human serum using boron-doped diamond electrodes2022
- Author(s)
  Moriyama Hideto、Ogata Genki、Nashimoto Haruma、Sawamura Seishiro、Furukawa Yoshiaki、Hibino Hiroshi、Kusuhara Hiroyuki、Einaga Yasuaki
- Journal Title
  
  The Analyst
  
  Volume: 147 Issue: 20 Pages: 4442-4449
- DOI
  10.1039/d2an01037b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19389, KAKENHI-PROJECT-21H03805, KAKENHI-PROJECT-20K16005, KAKENHI-PLANNED-19H05765
[Journal Article] Quantitative prediction of pharmacokinetic properties of drugs in humans: Recent advance in in vitro models to predict the impact of efflux transporters in the small intestine and blood brain barrier2022
- Author(s)
  Hashimoto Yoshiki、Michiba Kazuyoshi、Maeda Kazuya、Kusuhara Hiroyuki
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 148 Issue: 1 Pages: 142-151
- DOI
  10.1016/j.jphs.2021.10.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03401, KAKENHI-PROJECT-20H03402
[Journal Article] Prospect of in vitro Bile Fluids Collection in Improving Cell-Based Assay of Liver Function2021
- Author(s)
  Rizki-Safitri Astia、Tokito Fumiya、Nishikawa Masaki、Tanaka Minoru、Maeda Kazuya、Kusuhara Hiroyuki、Sakai Yasuyuki
- Journal Title
  
  Frontiers in Toxicology
  
  Volume: 3 Pages: 657432-657432
- DOI
  10.3389/ftox.2021.657432
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03401, KAKENHI-PLANNED-20H05745
[Journal Article] Current progress in identifying endogenous biomarker candidates for drug transporter phenotyping and their potential application to drug development2021
- Author(s)
  Mochizuki Tatsuki、Mizuno Tadahaya、Maeda Kazuya、Kusuhara Hiroyuki
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 37 Pages: 100358-100358
- DOI
  10.1016/j.dmpk.2020.09.003
- NAID
  210000177785
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03401, KAKENHI-PROJECT-20J14855
[Journal Article] Decomposition Profile Data Analysis for Deep Understanding of Multiple Effects of Natural Products2021
- Author(s)
  Nemoto Shumpei、Morita Katsuhisa、Mizuno Tadahaya、Kusuhara Hiroyuki
- Journal Title
  
  Journal of Natural Products
  
  Volume: 84 Issue: 4 Pages: 1283-1293
- DOI
  10.1021/acs.jnatprod.0c01381
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22485
[Journal Article] Alteration in the Plasma Concentrations of Endogenous Organic Anion-Transporting Polypeptide 1B Biomarkers in Patients With Non-Small Cell Lung Cancer Treated With Paclitaxel2020
- Author(s)
  Mori D, Ishida H, Mizuno T, Kusumoto S, Kondo Y, Izumi S, Nakata G, Nozaki Y, Maeda K, Sasaki Y, Fujita KI, Kusuhara H.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 48 Issue: 5 Pages: 387-394
- DOI
  10.1124/dmd.119.089474
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04100
[Journal Article] Identification of Appropriate Endogenous Biomarker for Risk Assessment of Multidrug and Toxin Extrusion Protein‐Mediated Drug‐Drug Interactions in Healthy Volunteers2020
- Author(s)
  Miyake Takeshi、Kimoto Emi、Luo Lina、Mathialagan Sumathy、Horlbogen Lauren M.、Ramanathan Ragu、Wood Linda S.、Johnson Jillian G.、Le Vu H.、Vourvahis Manoli、Rodrigues A. David、Muto Chieko、Furihata Kenichi、Sugiyama Yuichi、Kusuhara Hiroyuki
- Journal Title
  
  Clinical Pharmacology & Therapeutics
  
  Volume: 109 Issue: 2 Pages: 507-516
- DOI
  10.1002/cpt.2022
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03401
[Journal Article] Interesting Properties of Profile Data Analysis in the Understanding and Utilization of the Effects of Drugs2020
- Author(s)
  Mizuno Tadahaya、Morita Katsuhisa、Kusuhara Hiroyuki
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 43 Issue: 10 Pages: 1435-1442
- DOI
  10.1248/bpb.b20-00301
- NAID
  130007920894
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2020-10-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22485, KAKENHI-PROJECT-19K16407
[Journal Article] Dose-Dependent Inhibition of OATP1B by Rifampicin in Healthy Volunteers: Comprehensive Evaluation of Candidate Biomarkers and OATP1B Probe Drugs.2020
- Author(s)
  Mori D, Kimoto E, Rago B, Kondo Y, King-Ahmad A, Ramanathan R, Wood LS, Johnson JG, Le VH, Vourvahis M, David Rodrigues A, Muto C, Furihata K, Sugiyama Y, Kusuhara H
- Journal Title
  
  Clin Pharmacol Ther
  
  Volume: 107 Issue: 4 Pages: 1004-1013
- DOI
  10.1002/cpt.1695
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04100, KAKENHI-PROJECT-19H03392
[Journal Article] Decomposition Profile Data Analysis of Multiple Drug Effects Identifies Endoplasmic Reticulum Stress-Inducing Ability as an Unrecognized Factor2020
- Author(s)
  Katsuhisa Morita, Tadahaya Mizuno, Hiroyuki Kusuhara
- Journal Title
  
  Scientific Reports
  
  Volume: －
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22485
[Journal Article] Effect of Rifampicin on the Plasma Concentrations of Bile Acid-O-Sulfates in Monkeys and Human Liver-Transplanted Chimeric Mice With or Without Bile Flow Diversion2019
- Author(s)
  Issey Takehara, Nobuaki Watanabe, Daiki Mori, Osamu Ando, Hiroyuki Kusuhara
- Journal Title
  
  J Pharm Sci
  
  Volume: 108 Issue: 8 Pages: 2756-2764
- DOI
  10.1016/j.xphs.2019.03.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04100
[Journal Article] Estimation of changes in serum creatinine and creatinine clearance caused by renal transporter inhibition in healthy subjects2019
- Author(s)
  Nakada T, Kudo T, Kume T, Kusuhara H, Ito K
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 印刷中
- NAID
  50014558510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04100
[Journal Article] Development of Orthogonal Linear Separation Analysis (OLSA) to Decompose Drug Effects into Basic Components.2019
- Author(s)
  Mizuno T, Kinoshita S, Ito T, Maedera S, Kusuhara H.
- Journal Title
  
  Sci Rep
  
  Volume: 9 Issue: 1 Pages: 1824-1824
- DOI
  10.1038/s41598-019-38528-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19478
[Journal Article] Elucidation of N 1-methyladenosine as a Potential Surrogate Biomarker for Drug Interaction Studies Involving Renal Organic Cation Transporters2019
- Author(s)
  Miyake T, Mizuno T, Takehara I, Mochizuki T, Kimura M, Matsuki S, Irie S, Watanabe N, Kato Y, Ieiri I, Maeda K, Ando O, Kusuhara H.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 47 Issue: 11 Pages: 1270-1280
- DOI
  10.1124/dmd.119.087262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04100, KAKENHI-PROJECT-18J15304
[Journal Article] Development of <i>in vivo</i> drug sensing system with needle-type diamond microelectrode.2019
- Author(s)
  Ogata Genki、Asai Kai、Sano Yamato、Sawamura Seishirou、Takai Madoka、Kusuhara Hiroyuki、Einaga Yasuaki、Hibino Hiroshi
- Journal Title
  
  Proceedings for Annual Meeting of The Japanese Pharmacological Society
  
  Volume: 92 Issue: 0 Pages: 2-S14-4
- DOI
  10.1254/jpssuppl.92.0_2-S14-4
- NAID
  130007813110
- ISSN
  2435-4953
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-18H03513
[Journal Article] Development of in vivo drug sensing system with needle-type diamond microelectrode2019
- Author(s)
  Ogata Genki、Asai Kai、Sano Yamato、Sawamura Seishiro、Takai Madoka、Kusuhara Hiroyuki、Einaga Yasuaki、Hibino Hiroshi
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 153 Issue: 6 Pages: 273-277
- DOI
  10.1254/fpj.153.273
- NAID
  130007661321
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03513, KAKENHI-PROJECT-19F18411
[Journal Article] Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs, and their association in healthy volunteers.2019
- Author(s)
  Mori D, Kashihara Y, Yoshikado T, Kimura M, Hirota T, Matsuki S, Maeda K, Irie S, Ieiri I, Sugiyama Y, Kusuhara H.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 34 Issue: 1 Pages: 78-86
- DOI
  10.1016/j.dmpk.2018.09.003
- NAID
  50014558502
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04100, KAKENHI-PROJECT-17K15536
[Journal Article] PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3.2018
- Author(s)
  Yoshikado T., Toshimoto K., Maeda K., Kusuhara H., Kimoto E., Rodrigues AD., Chiba K., Sugiyama Y.
- Journal Title
  
  CPT Pharmacometrics Syst Pharmacol.
  
  Volume: 7 Issue: 11 Pages: 739-747
- DOI
  10.1002/psp4.12348
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08470, KAKENHI-PROJECT-17K15536, KAKENHI-PROJECT-17H04100
[Journal Article] Comparative study of the dose-dependence of OATP1B inhibition by rifampicin using probe drugs and endogenous substrates in healthy volunteers2018
- Author(s)
  Takehara I, Yoshikado T, Ishigame K, Mori D, Furihata K, Watanabe N, Ando O, Maeda K, Sugiyama Y, Kusuhara H
- Journal Title
  
  Pharmaceutical Research
  
  Volume: 2018 Pages: 2018-2018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04100
[Journal Article] Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug-Drug Interaction Evaluation: Perspectives From the International Transporter Consortium2018
- Author(s)
  Chu X, Liao M, Shen H, Yoshida K, Zur AA, Arya V, Galetin A, Giacomini KM, Hanna I, Kusuhara H, Lai Y, Rodrigues D, Sugiyama Y, Zamek-Gliszczynski MJ, Zhang L; International Transporter Consortium.
- Journal Title
  
  Clin Pharmacol Ther
  
  Volume: 104 Issue: 5 Pages: 836-864
- DOI
  10.1002/cpt.1216
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04100
[Journal Article] Endogenous Probes for Drug Transporters: Balancing Vision With Reality2017
- Author(s)
  Rodrigues AD、Taskar KS、Kusuhara H、Sugiyama Y
- Journal Title
  
  Clinical Pharmacology & Therapeutics
  
  Volume: 103 Issue: 3 Pages: 434-448
- DOI
  10.1002/cpt.749
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04100
[Journal Article] Involvement of Organic Cation Transporters in the Kinetics of Trimethylamine N-oxide2017
- Author(s)
  Miyake Takeshi、Mizuno Tadahaya、Mochizuki Tatsuki、Kimura Miyuki、Matsuki Shunji、Irie Shin、Ieiri Ichiro、Maeda Kazuya、Kusuhara Hiroyuki
- Journal Title
  
  Journal of Pharmaceutical Science
  
  Volume: 106 Issue: 9 Pages: 2542-2550
- DOI
  10.1016/j.xphs.2017.04.067
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04100
[Journal Article] Different involvement of OAT in renal disposition of oral anticoagulants rivaroxaban, dabigatran and apixaban2017
- Author(s)
  Tsuruya Y, Nakanishi T, Komori H, Wang X, Ishiguro N, Kito T, Ikukawa K, Kishimoto W, Ito S, Schaefer O, Ebner T, Yamamura N, Kusuhara H, Tamai I
- Journal Title
  
  J Pharm Sci
  
  Volume: 印刷中
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293032
[Journal Article] Investigation of the importance of multidrug resistance-associated protein 4 (Mrp4/Abcc4) in the active efflux of anionic drugs across the blood brain barrier2017
- Author(s)
  Kanamitsu K, Kusuhara H, Schuetz JD, Takeuchi K, Sugiyama Y
- Journal Title
  
  J Pharm Sci
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293032
[Journal Article] Pharmacokinetic Modeling and Monte Carlo Simulation to Predict Interindividual Variability in Human Exposure to Oseltamivir and Its Active Metabolite, Ro 64-0802.2017
- Author(s)
  Ito M, Kusuhara K, Ose A, Kondo T, Tanabe K, Nakayama H, Horita S, Fujita T, Sugiyama Y.
- Journal Title
  
  AAPS J
  
  Volume: 19 Issue: 1 Pages: 286-297
- DOI
  10.1208/s12248-016-9992-0
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-26293032, KAKENHI-PROJECT-26460210
[Journal Article] Involvement of Proton-Coupled Organic Cation Antiporter in Varenicline Transport at Blood-Brain Barrier of Rats and in Human Brain Capillary Endothelial Cells2017
- Author(s)
  Kurosawa T, Higuchi K, Okura T, Kobayashi K, Kusuhara H, Deguchi Y.
- Journal Title
  
  J Pharm Sci
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293032
[Journal Article] Involvement of Proton-Coupled Organic Cation Antiporter in Varenicline Transport at Blood-Brain Barrier of Rats and in Human Brain Capillary Endothelial Cells2017
- Author(s)
  Kurosawa T, Higuchi K, Okura T, Kobayashi K, Kusuhara H, Deguchi Y
- Journal Title
  
  J Pharm Sci
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293032
[Journal Article] Quantitative prediction of histamine H1 receptor occupancy by the sedative and non-sedative antagonists in the human central nervous system based on systemic exposure and preclinical data.2017
- Author(s)
  Kanamitsu K, Nozaki Y, Nagaya Y, Sugiyama Y, Kusuhara H.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 32 Issue: 2 Pages: 135-144
- DOI
  10.1016/j.dmpk.2016.11.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293032
[Journal Article] Investigation of utility of cerebrospinal fluid drug concentration as a surrogate for interstitial fluid concentration using microdialysis coupled with cisternal cerebrospinal fluid sampling in wild-type and Mdr1a(-/-) rats.2016
- Author(s)
  Nagaya Y, Nozaki Y, Takenaka O, Watari R, Kusano K, Yoshimura T, Kusuhara H
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 31 Issue: 1 Pages: 57-66
- DOI
  10.1016/j.dmpk.2015.10.003
- NAID
  50014431242
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293032
[Journal Article] Prediction of CNS occupancy of dopamine D2 receptor based on systemic exposure and in vitro experiments.2016
- Author(s)
  Kanamitsu K, Arakawa R, Sugiyama Y, Suhara T, Kusuhara H
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 31 Issue: 6 Pages: 395-404
- DOI
  10.1016/j.dmpk.2016.07.003
- NAID
  50014448705
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293032
[Journal Article] Investigation of Fluorescein Derivatives as Substrates of Organic Anion Transporting Polypeptide (OATP) 1B1 To Develop Sensitive Fluorescence-Based OATP1B1 Inhibition Assays.2016
- Author(s)
  Izumi S, Nozaki Y, Komori T, Takenaka O, Maeda K, Kusuhara H, Sugiyama Y
- Journal Title
  
  Mol Pharm
  
  Volume: なし
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293032
[Journal Article] Involvement of Organic Cation Transporters in the Clearance and Milk Secretion of Thiamine in Mice.2015
- Author(s)
  Kato K, Moriyama C, Ito N, Zhang X, Hachiuma K, Hagima N, Iwata K, Yamaguchi JI, Maeda K, Ito K, Suzuki H, Sugiyama Y, Kusuhara H.
- Journal Title
  
  Pharm Res
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23136101
[Journal Article] Involvement of Organic Cation Transporters in the Clearance and Milk Secretion of Thiamine in Mice.2015
- Author(s)
  Kato K, Moriyama C, Ito N, Zhang X, Hachiuma K, Hagima N, Iwata K, Yamaguchi JI, Maeda K, Ito K, Suzuki H, Sugiyama Y, Kusuhara H.
- Journal Title
  
  Pharm Res
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293032
[Journal Article] Solute Carrier Family of the Organic Anion-Transporting Polypeptides 1A2- Madin-Darby Canine Kidney II: A Promising In Vitro System to Understand the Role of Organic Anion-Transporting Polypeptide 1A2 in Blood-Brain Barrier Drug Penetration.2015
- Author(s)
  Liu H, Yu N, Lu S, Ito S, Zhang X, Prasad B, He E, Lu X, Li Y, Wang F, Xu H, An G, Unadkat JD, Kusuhara H, Sugiyama Y, Sahi J.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 43 Issue: 7 Pages: 1008-18
- DOI
  10.1124/dmd.115.064170
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293032, KAKENHI-PROJECT-24229002
[Journal Article] Investigation of endogenous compounds for assessing the drug interactions in the urinary excretion involving multidrug and toxin extrusion proteins2014
- Author(s)
  Kato K, Mori H, Kito T, Yokochi M, Ito S, Inoue K, Yonezawa A, Katsura T, Kumagai Y, Yuasa H, Moriyama Y, Inui K, Kusuhara H, Sugiyama Y
- Journal Title
  
  Pharm Res
  
  Volume: 31 Pages: 136-147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659071
[Journal Article] 6β-Hydroxycortisol is an endogenous probe for evaluation of drug-drug interactions involving a multispecific renal organic anion transporter, OAT3/SLC22A8, in healthy subjects2014
- Author(s)
  Imamura Y, Tsuruya Y, Damme K, Heer D, Kumagai Y, Maeda K, Murayama N, Okudaira N, Kurihara A, Izumi T, Sugiyama Y, Kusuhara H
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 42 Pages: 685-694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659071
[Journal Article] Quantitative Investigation of the Brain-to-Cerebrospinal Fluid Unbound Drug Concentration Ratio under Steady-State Conditions in Rats Using a Pharmacokinetic Model and Scaling Factors for Active Efflux Transporters.2014
- Author(s)
  Kodaira H, Kusuhara H, Fuse E, Ushiki J, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 42 Issue: 6 Pages: 983-989
- DOI
  10.1124/dmd.113.056606
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390034, KAKENHI-PROJECT-24229002
[Journal Article] Quantitative Investigation of the Brain-to-Cerebrospinal Fluid Unbound Drug Concentration Ratio under Steady-State Conditions in Rats Using a Pharmacokinetic Model and Scaling Factors for Active Efflux Transporters2014
- Author(s)
  Kodaira H, Kusuhara H, Fuse E, Ushiki J, Sugiyama Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 42 Pages: 983-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390034
[Journal Article] 6β-Hydroxycortisol is an endogenous probe for evaluation of drug-drug interactions involving a multispecific renal organic anion transporter, OAT3/SLC22A8, in healthy subjects.2014
- Author(s)
  Imamura Y, Tsuruya Y, Damme K, Heer D, Kumagai Y, Maeda K, Murayama N, Okudaira N, Kurihara A, Izumi T, Sugiyama Y, Kusuhara H.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 42 Issue: 4 Pages: 685-94
- DOI
  10.1124/dmd.113.055475
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-24659071
[Journal Article] DNA methylation and histone modification profiles of mouse organic anion transporting polypeptides2013
- Author(s)
  Imai S, Kikuchi R, Tsuruya Y, Naoi S, Nishida S, Kusuhara H, Sugiyama Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 41 Pages: 72-8
- NAID
  130004639789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390034
[Journal Article] Investigation of the effect of active efflux at the blood-brain barrier on the distribution of nonsteroidal aromatase inhibitors in the central nervous system.2013
- Author(s)
  Miyajima M, Kusuhara H, Takahashi K, Takashima T, Hosoya T, Watanabe Y, Sugiyama Y.
- Journal Title
  
  J Pharm Sci
  
  Volume: 102 Issue: 9 Pages: 3309-3319
- DOI
  10.1002/jps.23600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390034, KAKENHI-PROJECT-24229002
[Journal Article] Estimation of feasible solution space using Cluster Newton Method: application to pharmacokinetic analysis of irinotecan with physiologically- based pharmacokinetic models2013
- Author(s)
  Yoshida K, Maeda K, Kusuhara H, Konagaya A
- Journal Title
  
  BMC Systems Biology
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23136101
[Journal Article] Investigation of the role of transporters on the hepatic elimination of an LAT1 selective inhibitor JPH2032013
- Author(s)
  Toyoshima J, Kusuhara H, Wempe MF, Endou H, Sugiyama Y.
- Journal Title
  
  J Pharm Sci
  
  Volume: 102 Issue: 9 Pages: 3228-3238
- DOI
  10.1002/jps.23601
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23136101, KAKENHI-PROJECT-24229002
[Journal Article] Systems-based understanding of pharmacological responses with combinations of multidisciplinary methodologies2013
- Author(s)
  Yoshiaki Kariya, Masashi Honma, Hiroshi Suzuki
- Journal Title
  
  Biopharmaceutics & Drug Disposition
  
  Volume: 28(9) Issue: 9 Pages: 1936-1949
- DOI
  10.1002/jbmr.1941
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22136001, KAKENHI-PROJECT-24390349, KAKENHI-PROJECT-24890048, KAKENHI-PLANNED-22136015
[Journal Article] Evaluation of Oatp and Mrp2 activities in hepatobiliary excretion using newly developed positron emission tomography tracer [11C]dehydropravastatin in rats.2013
- Author(s)
  Shingaki T, Takashima T, Ijuin R, Zhang X, Onoue T, Katayama Y, Okauchi T, Hayashinaka E, Cui Y, Wada Y, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 347 Issue: 1 Pages: 193-202
- DOI
  10.1124/jpet.113.206425
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23136101, KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-24659574, KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
[Journal Article] Relationship between the urinary excretion mechanisms of drugs and their physicochemical properties2013
- Author(s)
  Ito S, Ando H, Ose A, Kitamura Y, Ando T, Kusuhara H, Sugiyama Y
- Journal Title
  
  J Pharm Sci
  
  Volume: 102 Pages: 3294-301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390034
[Journal Article] Effect of coadministration of single and multiple doses of rifampicin on the pharmacokinetics of fexofenadine enantiomers in healthy subjects.2013
- Author(s)
  Kusuhara H
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 41 Issue: 1 Pages: 206-13
- DOI
  10.1124/dmd.112.048330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390034, KAKENHI-PROJECT-24229002, KAKENHI-PLANNED-23136101
[Journal Article] Effect of coadministration of single and multiple doses of rifampicin on the pharmacokinetics of fexofenadine enantiomers in healthy subjects2013
- Author(s)
  Kusuhara H, Miura M, Yasui-Furukori N, Yoshida K, Akamine Y, Yokochi M, Fukizawa S, Ikejiri K, Kanamitsu K, Uno T, Sugiyama Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 41 Pages: 206-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390034
[Journal Article] Relationship between the urinary excretion mechanisms of drugs and their physicochemical properties.2013
- Author(s)
  Ito S, Ando H, Ose A, Kitamura Y, Ando T, Kusuhara H, Sugiyama Y.
- Journal Title
  
  J Pharm Sci
  
  Volume: 102 Issue: 9 Pages: 3294-3301
- DOI
  10.1002/jps.23599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390034, KAKENHI-PROJECT-24229002
[Journal Article] Drugs Interacting with organic anion transporter-1 affect uptake of Tc-99m-mercaptoacetyltriglycine (MAG3) in the human kidney : Therapeutic drug intereaction in Tc-99m-MAG3 diagnosis of renal function and possible application of Tc-99m-MAG3 for drug development2013
- Author(s)
  Takahara N, Saga T, Inubushi M, Kusuhara H, Seki C, Ito S, Oyama N, Yokoyama O, Sugiyama Y, Fujibayashi Y
- Journal Title
  
  Nucl Med Biol
  
  Volume: 40 Pages: 643-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390034
[Journal Article] Investigation of the effect of active efflux at the blood-brain barrier on the distribution of nonsteroidal aromatase inhibitors in the central nervous system2013
- Author(s)
  Miyajima M, Kusuhara H, Takahashi K, Takashima T, Hosoya T, Watanabe Y, Sugiyama Y
- Journal Title
  
  J Pharm Sci
  
  Volume: 102 Pages: 3309-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390034
[Journal Article] N-methylnicotinamide is an endogenous probe for evaluation of drug-drug interactions involving multidrug and toxin extrusions (MATE1 and MATE2-K)2012
- Author(s)
  Ito S, Kusuhara H, Kumagai Y, Moriyama Y, Inoue K, Kondo T, Nakayama H, Horita S, Tanabe K, Yuasa H, Sugiyama Y
- Journal Title
  
  Clin Pharmacol Ther
  
  Volume: 92 Pages: 635-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390034
[Journal Article] Regulation of Tissue-Specific Expression of Renal Organic Anion Transporters by Hepatocyte Nuclear Factor1 alpha/beta and DNA Methylation2012
- Author(s)
  Jin L、Kikuchi R、Saji T、Kusuhara H、Sugiyama Y
- Journal Title
  
  Pharmacol Exp Ther
  
  Volume: 340巻 Issue: 3 Pages: 648-655
- DOI
  10.1124/jpet.111.187161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Pharmacokinetic interaction study of sulfasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP2012
- Author(s)
  Kusuhara H, et al
- Journal Title
  
  Br J Pharmacol
  
  Volume: (In press) Issue: 6 Pages: 1793-1803
- DOI
  10.1111/j.1476-5381.2012.01887.x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23136101, KAKENHI-PROJECT-23590206, KAKENHI-PROJECT-24229002
[Journal Article] Competitive Inhibition of the Luminal Efflux by Multidrug and Toxin Extrusions, but Not Basolateral Uptake by Organic Cation Transporter 2, Is the Likely Mechanism Underlying the Pharmacokinetic Drug-Drug Interactions Caused by Cimetidine in the Kidney2012
- Author(s)
  Ito S、Kusuhara H、Yokochi M、ToyoshimaJ、Inoue K、Yuasa H、Sugiyama Y
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 340巻 Issue: 2 Pages: 393-403
- DOI
  10.1124/jpet.111.184986
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008, KAKENHI-PROJECT-24229002
[Journal Article] Regulation of tissue-specific expression of renal organic anion transporters by hepatocyte nuclear factor 1 α/β and DNA methylation2012
- Author(s)
  Jin L, Kikuchi R, Saji T, Kusuhara H, Sugiyama Y
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 340 Pages: 648-55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390034
[Journal Article] Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney2012
- Author(s)
  Ito S, Kusuhara H, Yokochi M, Toyoshima J, Inoue K, Yuasa H, Sugiyama Y
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 340 Pages: 393-403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390034
[Journal Article] Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving OAT3 in humans by in vitro uptake experiments.2011
- Author(s)
  Watanabe T, Kusuhara H, Watanabe T, Debori Y, Maeda K, Kondo T, Nakayama H, Horita S, Ogilvie BW, Parkinson A, Hu Z, Sugiyama Y
- Journal Title
  
  Drug Metab Dispos in press
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Prediction of fluoroquinolone-induced elevation in serum creatinine levels : a caseof drug-endogenous substance interaction involving the inhibition of renal secretion2011
- Author(s)
  Imamura Y、Murayama N、Okudaira N、Kurihara A、Okazaki O、Izumi T、Inoue K、Yuasa H、Kusuhara H、Sugiyama Y
- Journal Title
  
  Clin Pharmacol Ther
  
  Volume: 89巻 Issue: 1 Pages: 81-88
- DOI
  10.1038/clpt.2010.232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Prediction of the Overall Renal Tubular Secretion and Hepatic Clearance of Anionic Drugs and a Renal Drug-Drug Interaction Involving Organic Anion Transporter 3 in Humans byIn Vitro Uptake Experiments2011
- Author(s)
  Watanabe T、Kusuhara H、Watanabe T、Debori Y、Maeda K、Kondo T、NakayamaH、Horita S、Ogilvie BW、Parkinson A、Hu Z、Sugiyama Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 39巻 Issue: 6 Pages: 1031-1038
- DOI
  10.1124/dmd.110.036129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Quantitative evaluation of the impact of active efflux by p-glycoprotein and breast cancer resistance protein at the blood-brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as a surrogate2011
- Author(s)
  Kodaira H, Kusuhara H, Fujita T, Ushiki J, Fuse E, Sugiyama Y
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 339 Pages: 935-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390034
[Journal Article] Uptake of Transporter Substrates in Sandwich-Cultured Rat and Human Hepatocytes2011
- Author(s)
  Kotani N、Maeda K、Watanabe T、HiramatsuM、Gong L-K、Bi Y-A、Takezawa T、Kusuhara H、Sugiyama Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 39巻 Issue: 9 Pages: 1503-1510
- DOI
  10.1124/dmd.111.038968
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving OAT3 in humans by in vitro uptake experiments.2011
- Author(s)
  Watanabe T, Kusuhara H, Watanabe T, Debori Y, Maeda K, Kondo T, Nakayama H, Horita S, Ogilvie BW, Parkinson A, Hu Z, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: In press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Organic Anion Transporter 3 Mediates the Efflux Transport of an Amphipathic Organic Anion, Dehydroepiandrosterone Sulfate, across the Blood-Brain Barrier in Mice2011
- Author(s)
  Miyajima M、Kusuhara H、Fujishima M、Adachi Y、Sugiyama Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 39巻 Issue: 5 Pages: 814-819
- DOI
  10.1124/dmd.110.036863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Posttranslational negative regulation of glycosylated and non-glycosylated BCRP expression by Derlin-1.2011
- Author(s)
  Sugiyama T, Shuto T, Suzuki S, Sato T, Koga T, Suico MA, Kusuhara H, Sugiyama Y, Cyr DM, Kai H.
- Journal Title
  
  Biochem Biophys Res Commun. 404
  
  Pages: 853-858
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390046
[Journal Article] Organic anion transporter 3 mediates the efflux transport of an amphipathic organic anion, dehydroepi-androsterone sulfate, across the blood-brain barrier in mice.2011
- Author(s)
  Miyajima M, Kusuhara H, Fujishima M, Adachi Y, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos. 39
  
  Pages: 814-819
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390046
[Journal Article] Prediction of fluoroquinolone-induced elevation in serum creatinine levels : a case of drug-endogenous substance interaction involving the inhibition of renal secretion.2011
- Author(s)
  Imamura Y, Murayama N, Okudaira N, Kurihara A, Okazaki O, Izumi T, Inoue K, Yuasa H, Kusuhara H, Sugiyama Y.
- Journal Title
  
  Clin Pharmacol Ther
  
  Volume: 89 Pages: 81-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Quantitative evaluation of the impact of active efflux byp-glycoprotein and breast cancer resistance protein at the blood-brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as a surrogate2011
- Author(s)
  Kodaira H、Kusuhara H、Fujita T、Ushiki J、Fuse E、Sugiyama Y
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 339巻 Issue: 3 Pages: 935-944
- DOI
  10.1124/jpet.111.180398
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] The ATP-binding cassette transporter BCRP1/ABCG2 plays a pivotal role in cardiac repair after myocardial infarction via modulation of microvascular endothelial cell survival and function.2010
- Author(s)
  Higashikuni Y, Sainz J, Nakamura K, Takaoka M, Enomoto S, Iwata H, Sahara M, Tanaka K, Koibuchi N, Ito S, Kusuhara H, Sugiyama Y, Hirata Y, Nagai R, Sata M.
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 30
  
  Pages: 2128-2135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390046
[Journal Article] Kinetic Analysis of the Cooperation of P-glycoprotein(P-gp/Abcb1) and Breast Cancer Resistance Protein(Bcrp/Abcg2) in Limiting the Brainand Testis Penetration of Erlotinib, Flavopiridol, and Mitoxantrone2010
- Author(s)
  Kodaira H、Kusuhara H、Ushiki J、Fuse E、Sugiyama Y
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 333巻 Issue: 10 Pages: 788-796
- DOI
  10.1124/dmd.110.034652
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Direct and rapid genotyping of glutathione-S-transferase M1 and T1 from human blood specimens using the SmartAmp2 method.2010
- Author(s)
  Okada R, Ishizu Y, Endo R, Lezhava A, Ieiri I, Kusuhara H, Sugiyama Y, Hayashizaki Y.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 38 Pages: 1636-1639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Application of physiologically based pharmacokinetic modeling and clearance concept to drugs showing transporter-mediated distribution andclearance in humans2010
- Author(s)
  Watanabe T、Kusuhara H、Sugiyama Y
- Journal Title
  
  J Pharmacokinet Pharmacodyn
  
  Volume: 37巻 Issue: 6 Pages: 575-590
- DOI
  10.1007/s10928-010-9176-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] DNA Methylation Profiles of Organic Anion Transporting Polypeptide 1B3 in Cancer Cell Lines2010
- Author(s)
  Ichihara S, Kikuchi R, Kusuhara H, Imai S, Maeda K, Sugiyama Y.
- Journal Title
  
  Pharm Res 27(3)
  
  Pages: 510-516
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Kinetic Analysis of the Cooperation of P-glycoprotein (P-gp/Abcb1) and Breast Cancer Resistance Protein (Bcrp/Abcg2) in Limiting the Brain and Testis Penetration of Erlotinib, Flavopiridol, and Mitoxantrone2010
- Author(s)
  Hiroshi Kodaira, Hiroyuki Kusuhara, Junko Ushiki, Eiichi Fuse, Yuichi Sugiyama
- Journal Title
  
  J Pharmacol Exp Ther (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Positron emission tomography studies using (15R)-16-m-[11C]tolyl-17,18,19,20-tetra norisocarbacyclin methyl ester for the evaluation of hepatobiliary transport.2010
- Author(s)
  Takashima T, Nagata H, Nakae T, Cui Y, Wada Y, Kitamura S, Doi H, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
- Journal Title
  
  J Pharmacol Exp Ther 335
  
  Pages: 314-323
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Pharmacokinetic modeling of the hepatobiliary transport mediated by cooperation of uptake and efflux transporters2010
- Author(s)
  Kusuhara H、Sugiyama Y
- Journal Title
  
  Drug Metab Rev
  
  Volume: 42巻 Issue: 3 Pages: 539-550
- DOI
  10.1124/jpet.109.162321
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Basolateral Efflux Mediated by Multidrug Resistance-Associated Protein 3(Mrp3/Abcc3) Facilitates Intestinal Absorption of Folates in Mouse2010
- Author(s)
  Kitamura Y、Kusuhara H、Sugiyama Y
- Journal Title
  
  Pharm Res
  
  Volume: 27巻 Issue: 4 Pages: 665-672
- DOI
  10.1007/s11095-009-0047-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Application of physiologically based pharmacokinetic modeling and clearance concept to drugs showing transporter-mediated distribution and clearance in humans.2010
- Author(s)
  Watanabe T, Kusuhara H, Sugiyama Y.
- Journal Title
  
  J Pharmacokinet Pharmacodyn
  
  Volume: 37 Pages: 575-590
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Direct and rapid genotyping of glutathione-S-transferase M1 and T1 from human blood specimens using the SmartAmp2 method2010
- Author(s)
  Okada R、Ishizu Y、Endo R、Lezhava A、Ieiri I、Kusuhara H、Sugiyama Y、Hayashizaki Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 38巻 Issue: 2 Pages: 1636-1639
- DOI
  10.1124/jpet.110.170092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier2010
- Author(s)
  Ose A、Kusuhara H、Endo C、Tohyama K、Miyajima M、Kitamura S、Sugiyama Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 38巻 Issue: 2 Pages: 168-76
- DOI
  10.1124/jpet.109.156943
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier.2010
- Author(s)
  Ose A, Kusuhara H, Endo C, Tohyama K, Miyajima M, Kitamura S, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos 38
  
  Pages: 168-176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390046
[Journal Article] Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier.2010
- Author(s)
  Ose A, Kusuhara H, Endo C, Tohyama K, Miyajima M, Kitamura S, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos 38(1)
  
  Pages: 168-176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Positron emission tomography studies using (15R)-16-m-[11C]tolyl-17, 18, 19, 20-tetranorisocarbacyclin methyl ester for the evaluation of hepatobiliary transport.2010
- Author(s)
  Takashima T, Nagata H, Nakae T, Cui Y, Wada Y, Kitamura S, Doi H, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
- Journal Title
  
  J Pharmacol Exp Ther. 335
  
  Pages: 314-323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390046
[Journal Article] Application of physiologically based pharmacokinetic modeling and clearance concept to drugs showing transporter-mediated distribution and clearance in humans.2010
- Author(s)
  Watanabe T, Kusuhara H, Sugiyama Y.
- Journal Title
  
  J Pharmacokinet Pharmacodyn. 37
  
  Pages: 575-590
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390046
[Journal Article] Functional Characterization of Multidrug Resistance-Associated Protein 3(Mrp3/Abcc3) in the Basolateral Efflux of Glucuronide Conjugates in the Mouse Small Intestine2010
- Author(s)
  Kitamura Y、Kusuhara H、Sugiyama Y
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 332巻 Issue: 3 Pages: 659-666
- DOI
  10.1007/s11095-010-0064-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Pharmacokinetic modeling of the hepatobiliary transport mediated by cooperation of uptake and efflux transporters2010
- Author(s)
  Kusuhara H, et al
- Journal Title
  
  Drug Metab Rev (In press)
- Data Source
  KAKENHI-PROJECT-20056005
[Journal Article] Functional Characterization of Multidrug Resistance-Associated Proten 3 (Mrp3/Abcc3) in the Basolateral Efflux of Glucuronide Conjugates in the Mouse Small Intestine2010
- Author(s)
  Yoshiaki Kitamura, Hiroyuki Kusuhara, Yuichi Sugiyama
- Journal Title
  
  J Pharmacol Exp Ther 332
  
  Pages: 659-666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Positron emission tomography studies using(15R)-16-m-[11C]tolyl-17,18,19,20-tetranorisocarbacyclin methyl ester for the evaluation of hepatobiliary transport.2010
- Author(s)
  Takashima T, Nagata H, Nakae T, Cui Y, Wada Y, Kitamura S, Doi H, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 335 Pages: 314-323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Basolateral Efflux Mediated by Multidrug Resistance-Associated Protein 3 (Mrp3/Abcc3) Facilitates Intestinal Absorption of Folates in Mouse2010
- Author(s)
  Kitamura Y, Kusuhara H, Sugiyama Y.
- Journal Title
  
  Pharm Res 27(4)
  
  Pages: 665-672
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone.2010
- Author(s)
  Kodaira H, Kusuhara H, Ushiki J, Fuse E, Sugiyama Y.
- Journal Title
  
  J Pharmacol Exp Ther 333
  
  Pages: 788-796
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390046
[Journal Article] Pharmacokinetic modeling of the hepatobiliary transport mediated by cooperation of uptake and efflux transporters.2010
- Author(s)
  Kusuhara H, Sugiyama Y
- Journal Title
  
  Drug Metab Rev (In press)
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] 血液脳関門・腎尿細管分泌における薬物トランスポーターの役割2009
- Author(s)
  楠原洋之
- Journal Title
  
  遺伝子医学Mook12最新トランスポーター研究2009 12
  
  Pages: 128-139
- Data Source
  KAKENHI-PROJECT-20390046
[Journal Article] Construction of triple-transfected cells[ organic anion-transporting polypeptide(OATP) 1B1/multidrugresistance-associated protein(MRP) 2/MRP3 and OATP1B1/MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP42009
- Author(s)
  Hirouchi M、Kusuhara H、Onuki R、OgilvieBW、Parkinson A、Sugiyama Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 37巻 Issue: 1 Pages: 2103-2111
- DOI
  10.1124/dmd.109.029454
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] In vitro-in vivo extrapolation of transporter-mediated clearance in the liver and kidney2009
- Author(s)
  Kusuhara H, Sugiyama Y
- Journal Title
  
  Drug Metab Pharmacokinet 24
  
  Pages: 37-52
- NAID
  10025722604
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20056005
[Journal Article] The inhibition of human multidrug and toxin extrusion 1 is involved in the drug-drug interaction caused by cimetidine.2009
- Author(s)
  Matsushima S, Maeda K, Inoue K, Ohta KY, Yuasa H, Kondo T, Nakayama H, Horita S, Kusuhara H, Sugiyama Y
- Journal Title
  
  Drug Metab Dispos 37
  
  Pages: 555-559
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Physiologically Based Pharmacokinetic Modeling to Predict Transporter-mediated Clearance and Distribution of Pravastatin in Humans2009
- Author(s)
  Watanabe, T., Kusuhara, H., Maeda, K., Shitara, Y. and Sugiyama, Y.
- Journal Title
  
  J Pharmacol Exp Ther 328
  
  Pages: 652-662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20018006
[Journal Article] Construction of triple-transfected cells [organic anion-transporting polypeptide (OATP) 1B1/multidrug resistance-associated protein (MRP) 2/MRP3 and OATP1B1/MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP4.2009
- Author(s)
  Hirouchi M, Kusuhara H, Onuki R, Ogilvie BW, Parkinson A, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos 37(10)
  
  Pages: 2103-2111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] The inhibition of human multidrug and toxin extrusion 1 isinvolved in the drug-drug interaction causedby cimetidine2009
- Author(s)
  Matsushima S、Maeda K、Inoue K、Ohta KY、Yuasa H、Kondo T、Nakayama H、Horita S、Kusuhara H、Sugiyama Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 37巻 Issue: 3 Pages: 555-559
- DOI
  10.1124/dmd.108.023911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Limited brain distribution of [3R,4R,5S]-4?acetamido-5-amino 3-(1-ethylpropoxy)-1?cyclohexene-1-carboxylate phosphate (Ro64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic anion transporter 3 (Oat3/S1c22a8) and multidrug resi stance-associated protein 4 (Mrp4/Abcc4).2009
- Author(s)
  Ose A, Ito M, Kusuhara H, Yamatsugu K, Kanai M, Shibasaki M, Hosokawa M, Schuetz JD, Sugiyama Y
- Journal Title
  
  Drug Metab Dispos 37
  
  Pages: 315-321
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] Construction of triple-transfected cells [organic anion-transporting polypeptide (OATP) 1B1/multidrug resistance-associated protein (MRP) 2/MRP3 and OATPIBI/MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP4.2009
- Author(s)
  Hirouchi M, Kusuhara H, Onuki R, Ogilvie BW, Parkinson A, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos 37
  
  Pages: 2103-2111
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] In vitro-in vivo extrapolation of transporter- mediated clearance in the liver and kidney.2009
- Author(s)
  Kusuhara H, Sugiyama Y.
- Journal Title
  
  Drug Metab Pharmacokinet. 24
  
  Pages: 37-52
- NAID
  10025722604
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390046
[Journal Article] Limited brain distribution of[ 3R, 4R, 5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate(Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across theblood-brain barrier mediated by organic anion transporter 3(Oat3/Slc22a8) and multidrug resistance-associated protein 4(Mrp4/Abcc4)2009
- Author(s)
  Ose A、Ito M、Kusuhara H、Yamatsugu K、Kanai M、Shibasaki M、Hosokawa M、Schuetz JD、Sugiyama Y
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 37巻 Issue: 2 Pages: 315-321
- DOI
  10.1124/dmd.108.024018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249008
[Journal Article] In vitro-in vivo extrapolation of transporter-mediated clearance in the liver and kidney2009
- Author(s)
  Kusuhara H, Sugiyama Y
- Journal Title
  
  Drug Metab Pharmacokinet 24
  
  Pages: 37-52
- NAID
  10025722604
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390046
[Journal Article] Limited brain distribution of [3R, 4R, 5S]-4-acetamido -5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate (Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic anion transporter 3 (Oat3/Slc22a8) and multidrug resistance-associated protein 4 (Mrp4/Abcc4).2009
- Author(s)
  Ose A, Ito M, Kusuhara H, Yamatsugu K, Kanai M, Shibasaki M, Hosokawa M, Schuetz JD, Sugiyama Y.
- Journal Title
  
  Drug Metab Dispos 37
  
  Pages: 315-321
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390046
[Journal Article] Quantitative Investigation of the Role of Breast Cancer Resistance Protein (Bcrp/Abcg2) in Limiting Brain and Testis Penetration of Xenobiotic Compounds2008
- Author(s)
  Enokizono J, Kusuhara H, Ose A, Schinkel AH, Sugiyama Y
- Journal Title
  
  Drug Metab Dispos 36
  
  Pages: 995-1002
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390046
[Journal Article] Pharmacokinetic interaction between pravastatin and olmesartan in relation to SLCO1B1 polymorphism2008
- Author(s)
  Suwannakul S, Ieiri I, Kimura M, Kawabata K, Kusuhara H, Hirota T, Irie S, Sugiyama Y, Higuchi S
- Journal Title
  
  J Hum Genet 53
  
  Pages: 899-904
- NAID
  10022603002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20018006
[Journal Article] Involvement of MRP4 (ABCC4) in the luminal efflux of ceftizoxime and cefazolin in the kidney2007
- Author(s)
  Ci L, Kusuhara H, Adachi M, Schuetz JD, Sugiyama Y
- Journal Title
  
  Mol Pharmacol (in press)
- Data Source
  KAKENHI-PROJECT-17209005
[Journal Article] Sodium 4-phenylbutyrate induces functional cell surface expression of wild-type and PFIC2-type mutated BSEP2007
- Author(s)
  Hayashi H, Sugiyama Y
- Journal Title
  
  Hepatology (in press)
- Data Source
  KAKENHI-PROJECT-17209005
[Journal Article] Improvement of the oral drug absorption of topotecan through the inhibition of intestinal xenobiotic efflux transporter, breast cancer resistance protein, by excipients2007
- Author(s)
  Yamagata T, Kusuhara H, Morishita M, Takayama K, Benameur H, Sugiyama Y
- Journal Title
  
  Drug Metab Dispos 35
  
  Pages: 1142-1148
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390046
[Journal Article] Species difference in the inhibitory effect of nonsteroidal anti-inflammatory drugs on the uptake of methotrexate by human kidney slices2007
- Author(s)
  Nozaki Y, Kusuhara H, Kondo T, Iwaki M, Shiroyanagi Y, Nakayama H, Horita S, Nakazawa H, Okano T, Sugiyama Y
- Journal Title
  
  J Pharmacol Exp Ther 322
  
  Pages: 1162-1170
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390046
[Journal Article] ATP-binding cassette subfamily G (ABCG family)2007
- Author(s)
  Kusuhara H, et. al.
- Journal Title
  
  Pflugers Arch 453
  
  Pages: 735-744
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209005
[Journal Article] Effect of breast cancer resistance protein (Bcrp/Abcg2) on the disposition of2007
- Author(s)
  Enokizono J, Kusuhara H, Sugiyama Y
- Journal Title
  
  Mol Pharmacol 72
  
  Pages: 967-975
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390046
[Journal Article] ATP-binding cassette subfamily G (ABCG family)2007
- Author(s)
  Kusuhara H, Sugiyama Y
- Journal Title
  
  Pflugers Arch 453 (5)
  
  Pages: 735-44
- Data Source
  KAKENHI-PROJECT-17209005
[Journal Article] Functional involvement of multidrug resistance associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir2007
- Author(s)
  Imaoka T, Kusuhara H, Adachi M, Schuetz JD, Takeuchi K, Sugiyama Y
- Journal Title
  
  Mol Pharmacol 71 (2)
  
  Pages: 619-27
- Data Source
  KAKENHI-PROJECT-17209005
[Journal Article] Characterization of the uptake of organic anion transporter (OAT) 1 and OAT3 substrates by human kidney slices2007
- Author(s)
  Nozaki Y, Kusuhara H, Kondo T, Hasegawa M, Shiroyanagi Y, Nakazawa H, Okano T, Sugiyama Y
- Journal Title
  
  J Pharmacol Exp Ther 321
  
  Pages: 362-369
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390046
[Journal Article] Human Organic Anion Transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) Transport Edaravone (MCI-186; 3-methyl-l-phenyl-2-pyrazolin-5-one) and Its Sulfate Conjugate2007
- Author(s)
  Mizuno N, Takahashi T, Iwase Y, Kusuhara H, Niwa T, Sugiyama Y
- Journal Title
  
  Drug Metab Dispos 35
  
  Pages: 1429-1434
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390046
[Journal Article] Regional expression and activity of breast cancer resistance protein (ABCG2) in mouse intestine : overlapped distribution with sulfotransferases (SULTs)2007
- Author(s)
  Enokizono J, Kusuhara H, Sugiyama Y
- Journal Title
  
  Drug Metab Dispos (in press)
- Data Source
  KAKENHI-PROJECT-17209005
[Journal Article] Functional Analyses of Drug Transport in the Kidney2007
- Author(s)
  Kusuhara H
- Journal Title
  
  Novel Drug Development 2007 (Medical Do) 2007
  
  Pages: 149-154
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209005
[Journal Article] Involvement of Breast Cancer Resistance Protein (ABCG2) in the Biliary Excretion Mechanism of Fluoroquinolones2007
- Author(s)
  Ando T, Kusuhara H, Merino G, Alvarez AI, Schinkel AH, Sugiyama Y
- Journal Title
  
  Drug Metab dispos 35
  
  Pages: 1873-1879
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390046
[Journal Article] 4-phenylbutyrate enhances the cell surface expression and the transport capacity of wild-type and mutated bile salt export pumps2007
- Author(s)
  Hayashi H, et. al.
- Journal Title
  
  Hepatology 45
  
  Pages: 1506-1516
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209005
[Journal Article] Efflux mechanism of taurocholate across the rat intestinal basolateral membrane2006
- Author(s)
  Sakamoto S, Suzuki H, Kusuhara H, Sugiyama Y
- Journal Title
  
  Mol Pharm 3 (3)
  
  Pages: 275-81
- Data Source
  KAKENHI-PROJECT-17209005
[Journal Article] Efflux transport systems at the blood-brain barrier and blood-CSF barrier.2005
- Author(s)
  Kusuhara H, Sugiyama Y
- Journal Title
  
  the proceedings : Esteva Foundation Symposium X1 (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390035
[Journal Article] Active Efflux across the Blood-Brain Barrier : Role of the Solute Carrier Family.2005
- Author(s)
  Kusuhara H, Sugiyama Y
- Journal Title
  
  NeuroRx 2
  
  Pages: 73-85
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390035
[Journal Article] Efflux transport systems at the blood-brain barrier and blood-CSF barrier.2005
- Author(s)
  Kusuhara H, Sugiyama Y
- Journal Title
  
  Esteva Foundation Symposium X1 (in press)
- Data Source
  KAKENHI-PROJECT-15390035
[Journal Article] Efflux transport systems at the blood-brain barrier and blood-CSF barrier.2005
- Author(s)
  Kusuhara H, Sugiyama Y
- Journal Title
  
  Int Congr Ser 1277
  
  Pages: 111-122
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390035
[Patent] 生物応答の解析方法、解析プログラム、及び解析装置2018
- Inventor(s)
  楠原洋之,水野忠快, 木之下節夫,佐竹和子
- Industrial Property Rights Holder
  楠原洋之,水野忠快, 木之下節夫,佐竹和子
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-042467
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17K19478
[Presentation] Directional transport across a tight monolayer of intestinal epithelial cells at the ileum in dogs.2023
- Author(s)
  Hiroyuki Kusuhara, Yoshiko Nakajima, Yoshiki Hashimoto, Hiroki Takezaki, Kenpei Tai, Ikuko Kaisaki, Kazuya Maeda
- Organizer
  日本薬物動態学会第38回年会第23回シトクロムP450国際会議国際合同大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27337
[Presentation] Recent insights and advances in assessing drug interaction riskusing endogenous substrates of drug transporters2023
- Author(s)
  Hiroyuki Kusuhara
- Organizer
  日本薬物動態学会第38回年会第23回シトクロムP450国際会議国際合同大会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27337
[Presentation] Appropriate in vitro tool for the assessment of MATE-mediated DDI.2023
- Author(s)
  Asami Saito, Tomoko Kito, Masahito Takatani, Takashi Kudo, Bojan Bister, Naoki Ishiguro, Hiroyuki Kusuhara
- Organizer
  日本薬物動態学会第38回年会第23回シトクロムP450国際会議国際合同大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27337
[Presentation] Optimization of culture conditions to form a tight monolayer of intestinal epithelial cells at the duodenum, jejunum, and ileum in dogs2023
- Author(s)
  Hiroki Takezaki, Yoshiki Hashimoto, Akiko Moriyama, Kazuya Maeda, Hiroyuki Kusuhara
- Organizer
  日本薬物動態学会第38回年会第23回シトクロムP450国際会議国際合同大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27337
[Presentation] トランスポーター介在性薬物相互作用の定量的予測と臨床研究2023
- Author(s)
  楠原洋之
- Organizer
  第33回日本医療薬学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27337
[Presentation] Drug-drug interaction prediction using PBPK models2023
- Author(s)
  楠原洋之
- Organizer
  AP-ISSX2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] 薬物動態における肝・腎のトランスポーターの重要性と薬物相互作用2023
- Author(s)
  楠原洋之
- Organizer
  第7回日本臨床薬理学会九州・沖縄地方会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27337
[Presentation] Application of MPS to the ADME studies: in vitro model for the intestinal drug absorption2023
- Author(s)
  Hiroyuki Kusuhara
- Organizer
  MPS World Summit 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27337
[Presentation] 薬物トランスポーター介在性薬物相互作用を定量的に評価するためのバイオマーカーの探索と臨床研究2023
- Author(s)
  楠原洋之
- Organizer
  第35回バイオメディカル分析科学シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K27337
[Presentation] ヒトcryptスフェロイド由来分化小腸細胞における部位選択的なトランスポーター機能発現および発現誘導に関する検討2022
- Author(s)
  道場一祥、前田和哉、下村治、宮崎貴寛、橋本真治、大原佑介、榎本剛史、小田竜也、楠原洋之
- Organizer
  日本薬物動態学会第37年会
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] トランスポーター介在性薬物相互作用リスクの検出と予測のためのバイオマーカーの活用2022
- Author(s)
  楠原洋之
- Organizer
  日本動物実験代替法学会第35回大会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] 内因性基質を用いたトランスポーター介在性薬物相互作用の評価2022
- Author(s)
  楠原洋之
- Organizer
  題8回医薬品RSフォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] A Method Designed for Point-of-Care System Monitoring Plasma Concentration of an Anticancer Molecular Targeting Drug with Diamond Electrode2022
- Author(s)
  齋木琢郎，緒方元気，澤村晴志朗，ラズビナオリガ，渡邊航太，加藤里都，浅井開，松本吉史，森山雅人，楠原洋之，栄長泰明，西條康夫，日比野浩
- Organizer
  第 95 回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K21883
[Presentation] トランスポーター介在性薬物相互作用の定量的評価：臨床研究からモデル解析まで2022
- Author(s)
  楠原洋之
- Organizer
  薬物動態談話会第 45 年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] A Method Designed for Point-of-Care System Monitoring Plasma Concentration of an Anticancer Molecular Targeting Drug with Diamond Electrode2022
- Author(s)
  齋木琢郎，緒方元気，澤村晴志朗，ラズビナオリガ，渡邊航太，加藤里都，浅井開，松本吉史，森山雅人，楠原洋之，栄長泰明，西條康夫，日比野浩
- Organizer
  第 95 回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21H03805
[Presentation] Rapid Measurement of Drug Concentration of Pazopanib in Human Plasma with Diamond Sensor.2022
- Author(s)
  齋木琢郎，緒方元気，澤村晴志朗，ラズビナオリガ，渡邊航太，加藤里都，浅井開，松本吉史，森山雅人，楠原洋之，栄長泰明，西條康夫，日比野浩
- Organizer
  第19回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-20K21883
[Presentation] ヒト空腸スフェロイド由来小腸上皮細胞の薬物代謝酵素・トランスポーター基質薬物のヒト消化管吸収性予測における特性評価2022
- Author(s)
  道場一祥、前田和哉、下村治、宮崎貴寛、橋本真治、大原佑介、榎本剛史、小田竜也、楠原洋之
- Organizer
  医療薬学フォーラム2022
- Invited
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] Recent progress in in vitro models for drug transport study2022
- Author(s)
  楠原洋之
- Organizer
  The 5th transporter forum of Lanzhou
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] ヒトにおける新規化合物の薬物動態特性を評価するための in vitro モデルの開発2022
- Author(s)
  楠原洋之
- Organizer
  JPW2022
- Invited
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] MPSによるQuantitative Systems Pharmacologyの高度化への期待2022
- Author(s)
  楠原洋之
- Organizer
  細胞アッセイ研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] Rapid Measurement of Drug Concentration of Pazopanib in Human Plasma with Diamond Sensor2022
- Author(s)
  齋木琢郎，緒方元気，澤村晴志朗，ラズビナオリガ，渡邊航太，加藤里都，浅井開，松本吉史，森山雅人，楠原洋之，栄長泰明，西條康夫，日比野浩
- Organizer
  第19回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-21H03805
[Presentation] 新規化合物のヒト体内動態予測の現状と課題2022
- Author(s)
  楠原　洋之
- Organizer
  先端創薬科学講座セミナーコース2022
- Invited
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] ヒト初代培養細胞を用いたMPS開発と医薬品開発への展望2022
- Author(s)
  楠原　洋之
- Organizer
  レギュラトリーサイエンス学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] プロファイルデータ分離解析による天然物レシナミンの複合的作用の同定2021
- Author(s)
  根本駿平、森田勝久、水野忠快、楠原洋之
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K22485
[Presentation] 内在性代謝物を用いた薬物トラスポーターのフェノタイピングの現状と展望2021
- Author(s)
  楠原洋之
- Organizer
  第94回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] 血漿パゾパニブ濃度の迅速・簡便測定を目指した計測システムの構築2021
- Author(s)
  緒方元気、齋木琢郎、澤村晴志朗、ラズビナオリガ、渡邉航太、加藤理都、浅井開、花輪藍、松本吉史、森山雅人、西條康夫、楠原洋之、栄長泰明、日比野浩
- Organizer
  第60回日本生体医工学会大会
- Data Source
  KAKENHI-PROJECT-20K21883
[Presentation] 血漿パゾパニブ濃度の迅速・簡便測定を目指した計測システムの構築2021
- Author(s)
  緒方元気、齋木琢郎、澤村晴志朗、ラズビナオリガ、渡邉航太、加藤理都、浅井開、花輪藍、松本吉史、森山雅人、西條康夫、楠原洋之、栄長泰明、日比野浩
- Organizer
  第60回日本生体医工学会大会
- Data Source
  KAKENHI-PROJECT-21H03805
[Presentation] マウス消化管crypt由来分化細胞を活用した消化管吸収評価系の構築に向けた基礎検討2021
- Author(s)
  道場一祥、前田和哉、楠原洋之
- Organizer
  細胞アッセイ研究会「細胞アッセイ技術の現状と将来」
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] ダイヤモンド電極を用いた抗がん剤ドキソルビシンのヒト血清中遊離型測定2021
- Author(s)
  森山英人、緒方元気、梨本遥馬、古川良明、日比野浩、楠原洋之、栄長泰明
- Organizer
  2021年電気化学秋季大会
- Data Source
  KAKENHI-PROJECT-20K21883
[Presentation] rediction of transporter-mediated drug-drug interactions usingthe endogenous biomarkers2021
- Author(s)
  楠原洋之
- Organizer
  16th Korea-Japan Clinical Pharmacology Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] Analysis of hepatic uptake mechanism of daprodustat, a HIF-PH inhibitor using OATP1B-expression system2021
- Author(s)
  Nozomi Kubota, Tatsuki Mochizuki and Hiroyuki Kusuhara
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] Application of Transporter Biomarkers to DDI Risk Assessment2021
- Author(s)
  Hiroyuki Kusuhara
- Organizer
  An ISSX and IQ Consortium Virtual Workshop Event
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] 肝特異的トランスポーターSLC17A2の基質探索のための哺乳発現細胞の構築2021
- Author(s)
  梨本　遥馬、楠原洋之
- Organizer
  第28回HAB研究機構学術集会
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] プロファイルデータ分離解析による天然物誘導体シロシンゴピンのHDAC阻害作用の発見2021
- Author(s)
  森田勝久、水野忠快、楠原洋之
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K22485
[Presentation] Electrochemical detection of free drug fraction in human serum using boron-doped diamond electrodes.2021
- Author(s)
  Hideto Moriyama, Haruma Nashimoto, Genki Ogata, Yoshiaki Furukawa, Hiroshi Hibino, Hiroyuki Kusuhara, Yasuaki Einaga.
- Organizer
  The International Chemical Congress of Pacific Basin Societies 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21883
[Presentation] ダイヤモンド電極を用いた抗がん剤ドキソルビシンのヒト血清中遊離型測定2021
- Author(s)
  森山英人、緒方元気、梨本遥馬、古川良明、日比野浩、楠原洋之、栄長泰明
- Organizer
  2021電気化学秋季大会
- Data Source
  KAKENHI-PROJECT-21H03805
[Presentation] In vitro血液脳関門モデルを用いた薬物の方向性輸送に関わるトランスポーターの同定2021
- Author(s)
  楠原洋之
- Organizer
  日本薬剤学会第36年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] Electrochemical detection of free drug fraction in human serum using boron-doped diamond electrodes.2021
- Author(s)
  Hideto Moriyama, Haruma Nashimoto, Genki Ogata, Yoshiaki Furukawa, Hiroshi Hibino, Hiroyuki Kusuhara, Yasuaki Einaga.
- Organizer
  The International Chemical Congress of Pacific Basin Societies 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03805
[Presentation] 腎有機カチオントランスポーターOCT2の発現調節を担う遺伝子変異および転写因子の探索腎有機カチオントランスポーターOCT2の発現調節を担う遺伝子変異および転写因子の探索2020
- Author(s)
  三宅健之、水野忠快、楠原洋之
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] Plasma concentration changes of endogenous OATP1B1 substrates before and after paclitaxel administration in non-small cell lung cancer2020
- Author(s)
  Hiroyuki Kusuhara, Daiki Mori, Hiroo Ishida, Tadahaya Mizuno, Yusuke Kondo, Genki Nakada, Kazuya Maeda, Ken-Ichi Fujita
- Organizer
  PSWC2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] ダイヤモンドセンサを用いた電気化学測定による薬物血中濃度の迅速測定2020
- Author(s)
  齋木琢郎, 緒方元気, 澤村晴志朗, ラズビナオリガ, 渡邊航太, 加藤里都, 浅井開, 松本吉史, 森山雅人, 西條康夫, 楠原洋之, 栄長泰明, 日比野浩
- Organizer
  第 67 回中部日本生理学会
- Data Source
  KAKENHI-PROJECT-18H03513
[Presentation] マウス消化管crypt由来分化細胞培養系を活用した消化管における薬物輸送評価系の構築に向けた基礎検討2020
- Author(s)
  道場一祥、前田和哉、楠原洋之
- Organizer
  第5回トランスポーター研究会関東部会
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] MATE1介在性薬物相互作用を検出するための内因性バイオマーカーに関する探索的臨床研究2020
- Author(s)
  楠原洋之，三宅健之，木本絵美，Lina Luo，Lauren Horlbogen，Ragu Ramanathan，Vu H Le，Manoli Vourvahis，A. David Rodrigues，武藤智恵子，降旗謙一，杉山雄一
- Organizer
  第41回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] ダイヤモンドセンサを用いた電気化学測定に基づく、経口分子標的薬血漿中濃度の迅速・簡便な測定2020
- Author(s)
  齋木琢郎, 緒方元気, 澤村晴志朗, ラズビナオリガ, 渡邊航太, 加藤里都, 浅井開, 松本吉史, 森山雅人, 西條康夫, 楠原洋之, 栄長泰明, 日比野浩
- Organizer
  第 143 回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-18H03513
[Presentation] Rapid Measurement of Plasma Concentration of Pazopanib, a Multi-Kinase Inhibitor, with Diamond Sensor2020
- Author(s)
  齋木琢郎, 緒方元気, 澤村晴志朗, ラズビナオリガ, 渡邊航太, 加藤里都, 浅井開, 松本吉史, 森山雅人, 楠原洋之, 栄長泰明, 西條康夫, 日比野浩
- Organizer
  第18回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-18H03513
[Presentation] Investigation of intronic polymorphisms and transcription factors responsible for the OCT2 expression2020
- Author(s)
  Takeshi Miyake, Tadahaya Mizuno, Hiroyuki Kusuhara
- Organizer
  PSWC2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] 生体内の薬物動態とその作用をリアルタイム計測する局所薬物センサシステム2020
- Author(s)
  緒方元気、澤村晴志朗、浅井開、楠原洋之、栄長泰明、日比野浩
- Organizer
  生理学研究所研究会「細胞システム理解のためのシグナル応答原理解明の最前線」
- Data Source
  KAKENHI-PROJECT-18H03513
[Presentation] 腎有機カチオントランスポーターOCT2の発現調節を担う遺伝子変異および転写因子の探索2020
- Author(s)
  三宅健之、水野忠快、楠原洋之
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] A microsensing system for the in vivo real-time monitoring of local drug kinetics.2019
- Author(s)
  Genki Ogata, Kai Asai, Seishiro Sawamura, Hiroyuki Kusuhara, Yasuaki Einaga, Hiroshi Hibino
- Organizer
  International Symposium on Diamond Electrochemistry 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03513
[Presentation] Investigation of intronic polymorphisms and transcription factors that could be associated with interindividual difference in the OCT2 expression2019
- Author(s)
  Miyake T, Mizuno T, Ieiri I, Hirota G and Kusuhara H
- Organizer
  日本薬物動態学会第34回年会
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] A microsensing system for the in vivo real-time monitoring of local drug kinetics.2019
- Author(s)
  Genki Ogata, Kai, Asai, Yamato Sano, Seishiro Sawamura, Madoka Takai, Hiroyuki Kusuhara, Yasuaki Einaga, Hiroshi Hibino
- Organizer
  The 9th BRI International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03513
[Presentation] Comprehensive comparison of the effect of three doses of an OATP1B inhibitor, rifampicin, on the plasma concentrations of twenty-eight endogenous compounds in healthy volunteers2019
- Author(s)
  Hiroyuki Kusuhara,Daiki Mori, Emi Kimoto, Brian Rago, Yusuke Kondo, Amanda King-Ahmad, Ragu Ramanathan, Linda S. Wood, Jillian G. Johnson, Vu H. Le, Manoli Vourvahis, A. David Rodrigues, Chieko Muto, Kenichi Furihata, Yuichi Sugiyama
- Organizer
  日本薬物動態学会第34回年会
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] Clinical investigation of drug-transporter-mediated drug-drug interactions using endogenous substrates2019
- Author(s)
  Hiroyuki Kusuhara
- Organizer
  Biomedical Transporters 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] Evaluation of endogenous biomarkers of OATP1B activity in patients with non-small cell lung cancer who received paclitaxel2019
- Author(s)
  Hiroyuki Kusuhara, Daiki Mori, Hiroo Ishida, Tadahaya Mizuno, Ken-ichi Fujita, Sojiro Kusumoto, Kazuya Maeda, Yasutsuna Sasaki
- Organizer
  ISSX2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] Development of Orthogonal Linear Separation Analysis (OLSA) to Decompose Pharmacological Effect and Extract Elementary Ones2019
- Author(s)
  Hiroyuki Kusuhara
- Organizer
  第13回杉山特別研究室（理研）公開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K19478
[Presentation] 針状ダイヤモンド微小電極を駆使した生体内薬物センシングシステムの創出2019
- Author(s)
  緒方元気、浅井開、佐野大和、澤村晴志朗、高井まどか、楠原洋之、栄長泰明、日比野浩
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18H03513
[Presentation] A microsensing system for the in vivo real-time detection of local drug kinetics and local physiological activity.2019
- Author(s)
  Genki Ogata, Kai, Asai, Seishiro Sawamura, Madoka Takai, Hiroyuki Kusuhara, Yasuaki Einaga, Hiroshi Hibino
- Organizer
  The 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03513
[Presentation] ROLE OF DRUG TRANSPORTERS IN THE PHARMACOKINETICS OF DRUGS,AND THEIR ENDOGENOUS SUBSTRATES2019
- Author(s)
  Hiroyuki Kusuhara
- Organizer
  ICAPPS2019 AFPS2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] 内因性バイオマーカーを用いたトランスポーター介在性薬物相互作用の定量的評価2019
- Author(s)
  楠原洋之
- Organizer
  第23回薬物動態談話会セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] 針状ダイヤモンド電極による局所薬物動態の生体内実時間マイクロセンシングシステム2019
- Author(s)
  緒方元気，浅井開，澤村晴志朗，楠原洋之，栄長泰明，日比野浩
- Organizer
  NEURO2019
- Data Source
  KAKENHI-PROJECT-18H03513
[Presentation] 健康成人におけるリファンピシンによるOATP1B阻害の用量依存性に関する臨床研究2019
- Author(s)
  楠原洋之、森大輝、木本絵美、Brian Rago、近藤祐輔、Amanda King-Ahmad、Ragu Ramanathan、Manoli Vourvahis、A. David Rodriuges、武藤智恵子、降旗謙一、杉山雄一
- Organizer
  第40回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] 薬物トランスポーターの内在性基質を用いた薬物相互作用リスクの評価2019
- Author(s)
  楠原洋之
- Organizer
  Bioanalysis Form 2019
- Invited
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] Dose-dependent effect of probenecid on area under the plasma concentration time curves, and renal clearances of the endogenous OAT1/OAT3 biomarkers in healthy subjects2019
- Author(s)
  Yusuke Kondo, Tadahaya Mizuno, Kazuya Maeda, Hiroyuki Kusuhara
- Organizer
  日本薬物動態学会第34回年会
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] 腎トランスポーター介在性薬物相互作用を予測するための内因性バイオマーカー探索2019
- Author(s)
  楠原洋之
- Organizer
  第29回日本医療薬学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] 腎有機アニオントランスポーターOAT1, OAT3の機能バイオマーカー候補としての内因性基質探索2018
- Author(s)
  近藤祐輔、楠原洋之
- Organizer
  第4回　次世代を担う若手のためのレギュラトリーサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] てんかんのオーダメイド医療に資する埋込型薬物センサシステムの開発2018
- Author(s)
  緒方元気、浅井開、澤村晴志朗、楠原洋之、栄長泰明、日比野浩
- Organizer
  第69回日本薬理学会北部会
- Invited
- Data Source
  KAKENHI-PROJECT-18H03513
[Presentation] 肝・腎排泄におけるトランスポーターの役割2018
- Author(s)
  楠原洋之
- Organizer
  第３５回日本TDM学会・学術大会
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] Quantitative investigation of OATP1B-mediated drug-drug interactions using endogenous substrates2018
- Author(s)
  Hiroyuki Kusuhara
- Organizer
  22nd North American ISSX meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] 腎臓トランスポーター阻害による血清クレアチニン上昇機序の定量的考察2018
- Author(s)
  中田智久, 工藤敏之, 久米俊行, 楠原洋之, 伊藤清美
- Organizer
  医療薬学フォーラム2018
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] 臨床ステージで行う内在性バイオマーカーに基づくDDIリスク評価～腎トランスポーターを中心に～2018
- Author(s)
  楠原洋之
- Organizer
  第400回CBI学会講演会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] Investigation of endogenous biomarkers to assess the OATP activities in the body2018
- Author(s)
  Hiroyuki Kusuhara
- Organizer
  The 6th PROGRESS REPORT OF SUGIYAMA LABORATORY OPEN SYMPOSIUM
- Invited
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] Quantitative assessment of in vivo drug transporter activities using endogenous substrates2018
- Author(s)
  Hiroyuki Kusuhara
- Organizer
  APISSX2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] 内因性基質をプローブとしたパクリタキセルによるOATP1Bを介した薬物相互作用リスク評価2018
- Author(s)
  森大輝、石田博雄、水野忠快、藤田健一、楠本壮二郎、前田和哉、佐々木康綱、楠原洋之
- Organizer
  第13回トランスポーター研究会年会
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] INVESTIGATION OF DOSE DEPENDENT EFFECT OF RIFAMPICIN ON THE PLASMA CONCENTRATIONS OF ENDOGENOUS OATP1B SUBSTRATES IN HEALTHY VOLUNTEERS2018
- Author(s)
  Hiroyuki Kusuhara, Issey Takehara, Takashi Yoshikado, Keiko Ishigame, Daiki Mori, Ken-ichi Furihata, Nobuaki Watanabe, Osamu Ando, Kazuya Maeda, Yuichi Sugiyama
- Organizer
  APISSX2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] 腎有機カチオントランスポーターOCT2の機能プローブとしてのN1-methyladenosineの有用性の検討2018
- Author(s)
  三宅健之、水野忠快、望月達貴、木村美由紀、松木俊二、入江伸、家入一郎、前田和哉、楠原洋之
- Organizer
  第4回　次世代を担う若手のためのレギュラトリーサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] 生体内局所の薬物の濃度と作用の変動を同時計測するマイクロセンシングシステムの創出2018
- Author(s)
  緒方元気、浅井開、佐野大和、高井まどか、楠原洋之、栄長泰明、日比野浩
- Organizer
  第57回日本生体医工学会大会
- Data Source
  KAKENHI-PROJECT-18H03513
[Presentation] トランスポーター介在性薬物相互作用リスク評価への内在性バイオマーカーの適用2018
- Author(s)
  森大輝, 石田博雄, 水野忠快, 藤田健一, 楠本壮二郎, 前田和哉, 佐々木康綱, 楠原洋之
- Organizer
  第4回　次世代を担う若手のためのレギュラトリーサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] Investigation of endogenous substrates of OCT2 as surrogate biomarker for the prediction of transporter-mediated drug-drug interaction2018
- Author(s)
  Takeshi Miyake, Tadahaya Mizuno, Tatsuki Mochizuki, Miyuki Kimura, Shunji Matsuki, Shin Irie, Ichiro Ieiri, Kazuya Maeda, and Hiroyuki Kusuhara
- Organizer
  Globalization of Pharmaceutics Education Network (GPEN) Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs2018
- Author(s)
  Daiki Mori, Yushi Kashihara, Takashi Yoshikado, Miyuki Kimura, Takeshi Hirota, Shunji Matsuki, Kazuya Maeda, Shin Irie, Ichiro Ieiri, Yuichi Sugiyama, Hiroyuki Kusuhara
- Organizer
  日本薬物動態学会第33回年会/MDO 国際合同学会
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] Identification of N1-methyladenosine as a surrogate biomarker for drug interaction studies involving OCT22018
- Author(s)
  Takeshi Miyake, Tadahaya Mizuno, Tatsuki Mochizuki, Miyuki Kimura, Shunji Matsuki, Shin Irie, Ichiro Ieiri, Kazuya Maeda, and Hiroyuki Kusuhara
- Organizer
  日本薬物動態学会第33回年会/MDO 国際合同学会
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] Clinical Assessment of Renal Drug-drug Interactions using Endogenous substrate2018
- Author(s)
  Hiroyuki Kusuhara
- Organizer
  WCP2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] 腎有機カチオントランスポーターOCT2の機能バイオマーカー候補としての内因性基質探索2018
- Author(s)
  三宅健之、水野忠快、望月達貴、木村美由紀、松木俊二、入江伸、家入一郎、前田和哉、楠原洋之
- Organizer
  平成30年度生体コモンスペース研究会
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] Investigation of transporter mediated drug-drug interactions using endogenous biomarkers2017
- Author(s)
  Hiroyuki Kusuhara
- Organizer
  SSX2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] Investigation of endogenous substrates as surrogate biomarker for drug interaction studies involving OCT22017
- Author(s)
  Miyake T, Mizuno T, Mochizuki T, Kimura M, Matsuki S, Irie S, Ieiri I, Maeda K and Kusuhara H
- Organizer
  日本薬物動態学会第32回年会
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] OATP1Bプローブ薬と内在性基質のリファンピシン用量依存性の評価2017
- Author(s)
  楠原洋之、竹原一成、吉門崇、降旗謙一、渡邉伸明、安東治、前田和哉、杉山雄一
- Organizer
  第38回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] Assessment of drug-drug interaction potency against OATP1B with paclitaxel using an endogenous substrate as an alternative probe2017
- Author(s)
  Daiki Mori, Hiroo Ishida, Tadahaya Mizuno, Ken-ichi Fujita, Sojiro Kusumoto, Kazuya Maeda, Yasutsuna Sasaki, Hiroyuki Kusuhara
- Organizer
  日本薬物動態学会第32回年会
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] Investigation of endogenous probes for drug interaction studies involving OCT22017
- Author(s)
  Miyake T, Mizuno T, Kimura M, Matsuki S, Irie S, Ieiri I, Maeda K and Kusuhara H
- Organizer
  Biomedical Transporter
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] 内在性基質をプローブとした抗がん剤パクリタキセルによるOATP1B阻害の検出2017
- Author(s)
  森大輝、石田博雄、水野忠快、藤田健一、前田和哉、佐々木康綱、楠原洋之
- Organizer
  第38回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] Application of physiologically-based pharmacokinetic model to the drug-drug interaction assessment2017
- Author(s)
  Hiroyuki Kusuhara
- Organizer
  SOLVO’s Meet the Experts: Transporter Conference Tokyo 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] 腎有機カチオントランスポーターOCT2の機能低下を診断するバイオマーカーの探索2017
- Author(s)
  三宅健之、水野忠快、望月達貴、木村美由紀、松木俊二、入江伸、家入一郎、前田和哉、楠原洋之
- Organizer
  第38回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] Endogenous biomarkers for Renal Transporters2017
- Author(s)
  Kusuhara H
- Organizer
  International Transporter Consortium Workshop3
- Place of Presentation
  Omni Shoreham Hotel (Washington DC, USA)
- Year and Date
  2017-03-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293032
[Presentation] 分子論に基づいた体内動態予測と今後の展望2017
- Author(s)
  楠原洋之
- Organizer
  日本薬物動態学会第 31回ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] 薬物トランスポーターの内在性基質の探索と医薬品開発への利用2016
- Author(s)
  楠原洋之
- Organizer
  第１０回メタボロームシンポジウム
- Place of Presentation
  鶴岡メタボロームキャンパス (山形県鶴岡市)
- Year and Date
  2016-10-19
- Invited
- Data Source
  KAKENHI-PROJECT-26293032
[Presentation] Identification of endogenous biomarkers by metabolomics for clinical pharmacokinetic DDI study2016
- Author(s)
  Kusuhara H
- Organizer
  8th 杉山特別研究室（理研）公開シンポジウム
- Place of Presentation
  理化学研究所横浜事業所交流棟ホール(神奈川県鶴見市）
- Year and Date
  2016-10-16
- Data Source
  KAKENHI-PROJECT-26293032
[Presentation] Investigation of substrate specificity of mouse and human SLC35F2 in HEK293 cells2016
- Author(s)
  Mochizuki T, Mizuno T, Kusuhara H
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26293032
[Presentation] 脳におけるフリー薬物濃度を、in vitro試験、in silico試験より予測するための方法論の提案2016
- Author(s)
  楠原洋之
- Organizer
  第373回CBI学会講演会
- Place of Presentation
  東京大学山上会館（東京都文京区）
- Year and Date
  2016-06-02
- Invited
- Data Source
  KAKENHI-PROJECT-26293032
[Presentation] in vitroデータを基にした中枢での受容体占有率の予測2016
- Author(s)
  楠原洋之
- Organizer
  第378回CBI学会講演会
- Place of Presentation
  東京大学山上会館（東京都文京区）
- Year and Date
  2016-12-08
- Invited
- Data Source
  KAKENHI-PROJECT-26293032
[Presentation] Novel technologies to investigate the drug transporters in human body2016
- Author(s)
  Kusuhara H
- Organizer
  30th Anniversary Symposium of The Nagai Foundation Tokyo
- Place of Presentation
  帝国ホテル　（東京中央区）
- Year and Date
  2016-07-07
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293032
[Presentation] トランスポーターを介した薬物間相互作用予測のためのバイオマーカー2016
- Author(s)
  楠原洋之
- Organizer
  第29回日本動物実験代替法学会
- Place of Presentation
  九州大学医学部百年講堂(福岡県福岡市）
- Year and Date
  2016-11-16
- Invited
- Data Source
  KAKENHI-PROJECT-26293032
[Presentation] Investigation of substrate specificity of mouse and human SLC35F2 in HEK293 cells2016
- Author(s)
  Mochizuki T, Mizuno T, Kusuhara H
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K14998
[Presentation] 腎有機アニオントランスポーターの内在性基質の探索2015
- Author(s)
  鶴谷有理、楠原洋之
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎、長崎県
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26293032
[Presentation] 内在性化合物を用いた薬物相互作用の定量的評価2015
- Author(s)
  楠原洋之
- Organizer
  第36回日本臨床薬学会学術総会
- Place of Presentation
  新宿、東京
- Year and Date
  2015-12-09
- Invited
- Data Source
  KAKENHI-PROJECT-26293032
[Presentation] トリメチルアミンN-オキシドの腎取り込みおよび排泄に関わる輸送担体の解明2015
- Author(s)
  三宅健之、楠原洋之
- Organizer
  日本薬物動態学会第30回年会
- Place of Presentation
  船堀、東京
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-26293032
[Presentation] Integration of in vitro and animal data in modeling and simulation of D2 and H1 receptor occupancy by drugs in humans2015
- Author(s)
  Hiroyuki Kusuhara
- Organizer
  Barcelona BioMed Conference:Blood Brain Barrier
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2015-11-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293032
[Presentation] Is mild serum creatinine elevation a sign of transporter-mediated drug interactions?2015
- Author(s)
  楠原洋之
- Organizer
  日本薬物動態学会　第30回年会
- Place of Presentation
  船堀、東京
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-26293032
[Presentation] Investigation of endogenous compounds for quantitative evaluation of drug interactions involving renal organic anion transporters2015
- Author(s)
  Yamato Sano, Yuri Tsuruya, Kazuya Maeda, and Hiroyuki Kusuhara
- Organizer
  日本薬物動態学会第30回年会
- Place of Presentation
  船堀、東京
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-26293032
[Presentation] Organic Cation Transporter 2 (OCT2) is responsible for the renal influx of trimethylamine N-oxide (TMAO)2015
- Author(s)
  三宅健之、楠原洋之
- Organizer
  第21回創剤フォーラム若手研究会
- Place of Presentation
  本郷、東京
- Year and Date
  2015-11-28
- Data Source
  KAKENHI-PROJECT-26293032
[Presentation] Prediction of drug interactions using endogenous compounds; importance ofpharmacokinetic model2015
- Author(s)
  Hiroyuki Kusuhara
- Organizer
  6th Sugiyama Laboratory Open Symposium
- Place of Presentation
  横浜、神奈川
- Year and Date
  2015-08-27
- Invited
- Data Source
  KAKENHI-PROJECT-26293032
[Presentation] チアミンの組織移行および尿排泄における有機カチオントランスポーターＯＣＴ１、ＯＣＴ２およびＭＡＴＥの関与2014
- Author(s)
  楠原洋之、加藤幸司、山口順一、伊藤直樹、鈴木洋史、杉山雄一
- Organizer
  肝病態生理研究会
- Place of Presentation
  東京
- Year and Date
  2014-05-31
- Data Source
  KAKENHI-PROJECT-26293032
[Presentation] 前臨床試験に基づいた脳受容体占有率時間推移の予測2014
- Author(s)
  楠原洋之
- Organizer
  第４回　杉山特別研究室（理研）公開シンポジウム
- Place of Presentation
  東京
- Year and Date
  2014-09-25
- Invited
- Data Source
  KAKENHI-PROJECT-26293032
[Presentation] 前臨床試験に基づいた脳受容体占有率時間推移の予測2014
- Author(s)
  楠原洋之
- Organizer
  第4回杉山特別研究室（理研）公開シンポジウム
- Place of Presentation
  東京
- Year and Date
  2014-09-25
- Invited
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] In vivo evaluation of transporter activities using positron emission tomography (PET)2014
- Author(s)
  Kusuhara H
- Organizer
  5th FEBS Special Meeting ATP-Binding Cassette (ABC) proteins
- Place of Presentation
  Innsbruck, Austria
- Invited
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] 肝異物排泄におけるトランスポーターの重要性2014
- Author(s)
  楠原洋之、前田和哉
- Organizer
  第３回日本くすりと糖尿病学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2014-11-03
- Invited
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] 薬物トランスポーターの生理学的基質の探索2014
- Author(s)
  楠原洋之
- Organizer
  日本薬学会134年会
- Place of Presentation
  熊本
- Invited
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] ヒト薬物動態を予測するためのin vitroシステム2014
- Author(s)
  楠原洋之
- Organizer
  日本組織培養学会第８７回大会
- Place of Presentation
  東京
- Year and Date
  2014-05-30
- Invited
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] 肝異物排泄におけるトランスポーターの個人間変動とＰＥＴを用いたin vivo輸送能力の評価2014
- Author(s)
  楠原洋之、前田和哉
- Organizer
  第３５回日本臨床薬理学会学術集会
- Place of Presentation
  松山
- Year and Date
  2014-12-05
- Invited
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] Application of a Novel Computational Method to Estimate Feasible Solution Spaces for Determining Multiple Parameters in Physiologically-based Pharmacokinetic (PBPK) Model2013
- Author(s)
  Maeda K, Yoshida K, Kusuhara H, Konagaya A, Sugiyama Y
- Organizer
  10th International ISSX Meeting
- Place of Presentation
  Ontario, Canada
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] 血液脳関門を介した薬物輸送：脳内受容体占有率の予測法2013
- Author(s)
  楠原洋之
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-27
- Invited
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] Quantitative prediction of the effect of multiple pharmacokinetic interactions using physiologically-based pharmacokinetic (PBPK) models through the analyses with Cluster Newton Method2013
- Author(s)
  Yoshida K, Maeda K, Kusuhara H, Konagaya A, Sugiyama Y
- Organizer
  28th JSSX Annual Meeting
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] Identification of major substrates of efflux transporters in vivo by metabolomics analysis2013
- Author(s)
  楠原洋之
- Organizer
  Gordon Research Conference Multi-Drug Efflux Systems
- Place of Presentation
  Ventura、USA
- Data Source
  KAKENHI-PROJECT-24659071
[Presentation] Precise estimation of the contribution of CYP enzymes to overall metabolism from in vivo information: application of Cluster Newton Method2013
- Author(s)
  Yoshida K, Maeda K, Kusuhara H, Sugiyama Y, Konagaya A
- Organizer
  CBI学会2013年大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] INVESTIGATION OF THE IMPORATANCE OF MULTIDRUG AND TOXIC COMPOUND EXTRUSION IN THE URINARY EXCRETION OF CATIONIC DRUGS IN MOUSE2013
- Author(s)
  Kusuhara H, Ito S, Inoue K, Yuasa H, Moriyama Y, Sugiyama Y.
- Organizer
  10th International ISSX Meeting
- Place of Presentation
  Ontario, Canada
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] Quantitative prediction of drug-drug interactions involving repaglinide, gemfibrozil, and itraconazole using a new computational method to estimate feasible solution spaces2013
- Author(s)
  Yoshida K, Maeda K, Kusuhara H, Konagaya A, Sugiyama Y
- Organizer
  2nd HD physiology International Symposium
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] 薬物トランスポーターの発現・機能変動に伴い血漿中濃度・尿中排泄が変動する代謝物の探索2013
- Author(s)
  楠原洋之
- Organizer
  第８６回日本生化学会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-24659071
[Presentation] 薬物トランスポーターの発現・機能変動に伴い血漿中濃度・尿中排泄が変動する代謝物の探索2013
- Author(s)
  楠原洋之
- Organizer
  第86回日本生化学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24659071
[Presentation] The role of transporters in absorption and the relevance of drug-drug interactions2013
- Author(s)
  Kusuhara H
- Organizer
  5th World Conference on Drug Absorption, Transport and Delivery (WCDATD):responding to challenging situations
- Place of Presentation
  Uppsala, Sweden
- Invited
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] Identification of major substrates of efflux transporters in vivo by metabolomic analysis2013
- Author(s)
  楠原　洋之
- Organizer
  Gordon Research Conference Multi-Drug Efflux Systems
- Place of Presentation
  Ventura, USA
- Invited
- Data Source
  KAKENHI-PROJECT-24659071
[Presentation] 薬物トランスポーターによる細胞内からの排出輸送過程における薬物間相互作用の評価2013
- Author(s)
  楠原洋之
- Organizer
  第４０回日本毒性学会学術年会
- Place of Presentation
  千葉
- Invited
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] ROLE OF ABC TRANSPORTERS IN THE DRUG DISPOSITION:INTERPLAY BETWEEN UPTAKE AND EFFLUX TRANSPORTERS2012
- Author(s)
  楠原　洋之
- Organizer
  18th North American Regional Meeting
- Place of Presentation
  Dallas, USA
- Invited
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] Drug-transport interactions : kinetic concepts and clinical studies to demonstrate relevance of in vitro mode predictions2012
- Author(s)
  楠原洋之
- Organizer
  GPEN2012
- Place of Presentation
  Melbourne, Australia
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] Use of microdosing PET studies in new drug discovery and development: Development of PET probes for drug transporters2012
- Author(s)
  楠原洋之
- Organizer
  Symposium on Functional and Molecular Imaging in Drug Discovery and Development
- Place of Presentation
  Soul, Korea
- Year and Date
  2012-11-02
- Invited
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] 腎臓での薬物間相互作用の予測2012
- Author(s)
  楠原洋之
- Organizer
  第332回CBI学会研究講演会
- Place of Presentation
  東京
- Year and Date
  2012-12-04
- Invited
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] Drug Transporters: clinical relevance and prediction from preclinical animal model and in vitro model2012
- Author(s)
  楠原　洋之
- Organizer
  APA2012
- Place of Presentation
  Baltimore, USA
- Invited
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] Role of organic ion transporters in the renal elimination of drugs : clinical investigation using in vivo inhibitors2012
- Author(s)
  楠原洋之, 他
- Organizer
  2nd Annual Clinical Relevant Drug Transporters
- Place of Presentation
  Berlin, Germany
- Year and Date
  2012-04-12
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] Drug Transporters : clinical relevance and prediction from preclinical animal model and in vitro model2012
- Author(s)
  楠原洋之
- Organizer
  APA2012
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] Recent Developments in Drug-Transporter Research2012
- Author(s)
  楠原洋之
- Organizer
  2012 AAPS Annual Meeting and Exposition
- Place of Presentation
  Chicago、USA
- Data Source
  KAKENHI-PROJECT-24659071
[Presentation] メタボローム解析に基づいた薬物間相互作用研究2012
- Author(s)
  楠原洋之, 他
- Organizer
  日本薬学会132年会
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] Recent Developments in Drug-Transporter Research2012
- Author(s)
  楠原　洋之
- Organizer
  2012 AAPS Annual Meeting and Exposition
- Place of Presentation
  Chicago, USA
- Invited
- Data Source
  KAKENHI-PROJECT-24659071
[Presentation] Use of microdosing PET studies in new drug discovery and development : Development of PET probes for drug transporters2012
- Author(s)
  楠原洋之
- Organizer
  Symposium on Functional and Molecular Imaging in Drug Discovery and Development
- Place of Presentation
  Soul, Korea
- Year and Date
  2012-11-02
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] マイクロドーズ試験に基づいた体内動態特性の評価と薬剤応答性の予測2012
- Author(s)
  楠原洋之
- Organizer
  日本動物実験代替法学会第26回大会開催
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] 腎臓での薬物間相互作用の予測2012
- Author(s)
  楠原洋之
- Organizer
  第332回CBI 学科い研究講演会
- Place of Presentation
  東京
- Year and Date
  2012-12-14
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] Quantitative Investigation of Drug Transport across the BBB2012
- Author(s)
  楠原洋之
- Organizer
  CPSA Shanghai 2012
- Place of Presentation
  Shanghai, China
- Year and Date
  2012-04-26
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] Role of ABC transporters in the drug disposition : interplay between uptake and efflux transporters2012
- Author(s)
  楠原洋之
- Organizer
  18th North American Regional Meeting
- Place of Presentation
  Dallas, USA
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] Drug-transport interactions: kinetic concepts and clinical studies to demonstrate relevance of in vitro model predictions2012
- Author(s)
  楠原　洋之
- Organizer
  GPEN2012
- Place of Presentation
  Melbourne,　Australia
- Invited
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] Quantitative evaluation of the impact of active efflux by P-gp and Bcrp at the BBB on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as surrogate2011
- Author(s)
  楠原洋之
- Organizer
  Biomedical Transporters
- Place of Presentation
  グリンデルワルト、スイス(招待講演)
- Year and Date
  2011-08-11
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] Quantitative evaluation of the impact of active efflux by P-gp and Bcrp at the BBB on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as surrogate2011
- Author(s)
  楠原洋之
- Organizer
  Biomedical Transporters
- Place of Presentation
  Grindelwald, Switzerland
- Year and Date
  2011-08-11
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] Investigation of in vivo drug-drug interactions involving renal organic cation transporters using endogenous substrate2011
- Author(s)
  楠原洋之, 他
- Organizer
  第5回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] Role of organic ion transporters in the renal elimination of drugs : clinical investigation using in vivo inhibitors2011
- Author(s)
  楠原洋之
- Organizer
  2^<nd> Annual Clinically Relevant Drug Transporters
- Place of Presentation
  ベルリン、ドイツ(招待講演)
- Year and Date
  2011-04-12
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] Investigation of the drug-drug interaction mechanism of cimetidine in the renal elimination process2011
- Author(s)
  楠原洋之, 他
- Organizer
  26th JSSX meeting
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] Importance of drug transport in clinical PK or target effects2011
- Author(s)
  楠原洋之
- Organizer
  Gordon Research Conference
- Place of Presentation
  ニューハンプシャー州、アメリカ(招待講演)
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] Importance of drug transport in clinical PK or target effects2011
- Author(s)
  楠原洋之
- Organizer
  Gordon Research Conference
- Place of Presentation
  New Hampshire, USA
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] IVIVE for hepatic and renal transporters2010
- Author(s)
  楠原洋之
- Organizer
  FIP Pharmaceutical Sciences 2010 World Congress/AAPS Annual Meeting and Exposition
- Place of Presentation
  New Orleans, USA(招待講演)
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] Modulation of drug response by transporter-mediated membrane transport2010
- Author(s)
  Hiroyuki Kusuhara
- Organizer
  New Horizons in Toxicity Prediction, The 2^nd International Lhasa symposium
- Place of Presentation
  Leeds, UK
- Year and Date
  2010-09-16
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] マイクロドーズ臨床試験による医薬品体内動態特性評2010
- Author(s)
  楠原洋之
- Organizer
  第35回医用マススペクトル学会年会
- Place of Presentation
  名古屋
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] 血液脳関門・血液脳脊髄液関門の能動的関門機構としてのABCトランスボーターMRP4の重要性2010
- Author(s)
  楠原洋之, 他
- Organizer
  第4回トランスポーター研究会九州部会
- Place of Presentation
  長崎
- Year and Date
  2010-09-12
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] Role of Transport in Drug Disposition2010
- Author(s)
  Hiroyuki Kusuhara
- Organizer
  GPEN 2010
- Place of Presentation
  North Carolina, USA
- Year and Date
  2010-11-11
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Role of drug transporters in the blood-brain barrier2010
- Author(s)
  Hiroyuki Kusuhara
- Organizer
  4^th international symposium on drug transporters、
- Place of Presentation
  Seoul, Korea
- Year and Date
  2010-05-26
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Modulation of Drug Response by Transporter-Mediated Membrane Transport2010
- Author(s)
  Hiroyuki Kusuhara
- Organizer
  New Horizons in Toxicity Prediction The 2^<nd> Inter national Lhasa Symposium
- Place of Presentation
  Leeds, UK
- Year and Date
  2010-09-16
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] マイクロドーズ臨床試験による医薬品体内動態特性評価2010
- Author(s)
  楠原洋之
- Organizer
  第35回医用マススペクトル学会年会(招待講演)
- Place of Presentation
  名古屋
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] 医薬品体内動態における薬物トランスポーターの役割:機能変動が薬剤応答性に与える影響2010
- Author(s)
  楠原洋之
- Organizer
  日本毒性病理学会第11会教育セミナー
- Place of Presentation
  大阪
- Year and Date
  2010-11-06
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] Role of Drug Transporters in Modulation of Drug Response by Transporter-Mediated Membrane Transport2010
- Author(s)
  楠原洋之
- Organizer
  New Horizons in Toxicity Prediction The 2nd International Lhasa Symposium(招待講演)
- Place of Presentation
  Leeds, UK
- Year and Date
  2010-09-16
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] Modulation of Drug Response by Transporter-Mediated Membrane Transport2010
- Author(s)
  Hiroyuki Kusuhara
- Organizer
  GPEN2010
- Place of Presentation
  North Carolina, USA
- Year and Date
  2010-11-12
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] 葉酸吸収におけるMRP3/ABCC3の役割2010
- Author(s)
  楠原洋之, 他
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-20014005
[Presentation] Role of drug transporters in the blood-brain barrier2010
- Author(s)
  Hiroyuki Kusuhara
- Organizer
  4^<th> international symposium on drug transporters
- Place of Presentation
  Seoul, Korea
- Year and Date
  2010-05-26
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] IVIVE for hepatic and renal transporters2010
- Author(s)
  Hiroyuki Kusuhara, Yuichi Sugiyama
- Organizer
  2010 FIP PSWC/RAPS annual meeting and exposition
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Role of Drug Transporters in the Blood-Brain Barrier2010
- Author(s)
  Hiroyuki Kusuhara
- Organizer
  4th International Symposium Rational Integration of Transport Metabolism and Drug Delivery
- Place of Presentation
  Soul, Korea
- Year and Date
  2010-05-26
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] Modulation of drug response by transporter-mediated membrane transport2010
- Author(s)
  Hiroyuki Kusuhara
- Organizer
  New Horizons in Toxicity Prediction, The 2^<nd> International Lhasa symposium
- Place of Presentation
  Leeds, UK
- Year and Date
  2010-09-16
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] 血液脳関門・血液脳脊髄液関門の能動的関門機構としての有機アニオントランスポーターOAT3の重要性2010
- Author(s)
  楠原洋之、小平浩史、宮島真理、杉山雄一
- Organizer
  第4回トランスボーター研究会九州部会
- Place of Presentation
  長崎
- Year and Date
  2010-09-12
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] 医薬体内動態における薬物トランスポーターの重要性2010
- Author(s)
  楠原洋之
- Organizer
  第13回日本医薬品情報学会
- Place of Presentation
  浜松
- Year and Date
  2010-07-24
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] 血液脳関門・血液脳脊髄液関門の能動的関門機構としての有機アニオントランスポーターOAT3の重要性2010
- Author(s)
  楠原洋之, 他
- Organizer
  第4回トランスポーター研究会九州部会
- Place of Presentation
  長崎
- Year and Date
  2010-09-12
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] IVIVE for hepatic and renal transporters2010
- Author(s)
  Hiroyuki Kusuhara
- Organizer
  FIP Pharmaceutical Sciences 2010 World Congress/AAPS Annual Meeting and Exposition
- Place of Presentation
  New Orleans, USA
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] トランスポーターを介した薬物間相互作用の予測2010
- Author(s)
  楠原洋之
- Organizer
  医療薬学フォーラム2010
- Place of Presentation
  広島
- Year and Date
  2010-07-11
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] Modulation of Drug Response by Transporter .Mediated Membrane Transport2010
- Author(s)
  楠原洋之
- Organizer
  GPEN2010
- Place of Presentation
  North Carolina, USA(招待講演)
- Year and Date
  2010-11-12
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] 血液脳関門・血液脳脊髄液関門の能動的関門機構としてのABCトランスポーターMRP4の重要性2010
- Author(s)
  楠原洋之, 他
- Organizer
  第4回トランスポーター研究会九州部会
- Place of Presentation
  長崎
- Year and Date
  2010-09-12
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] 医薬品体内動態における薬物トランスポーターの役割:機能変動が薬剤応答性に与える影響2010
- Author(s)
  楠原洋之
- Organizer
  日本毒性病理学会第11会教育セミナー(招待講演)
- Place of Presentation
  大阪
- Year and Date
  2010-11-06
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] IVIVE for hepatic and renal transporters2010
- Author(s)
  Hiroyuki Kusuhara, Yuichi Sugiyama
- Organizer
  2010 FIP PSWC/AAPS annual meeting and exposition
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Role of Drug Transporters in the Blood-Brain Barrier2010
- Author(s)
  楠原洋之
- Organizer
  4th International Symposium Rational Integration of Transport Metabolism and Drug Delivery(招待講演)
- Place of Presentation
  Soul, Korea
- Year and Date
  2010-05-26
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] トランスポーターを介した薬物間相互作用の予測2010
- Author(s)
  楠原洋之
- Organizer
  医療薬学フォーラム2010(招待講演)
- Place of Presentation
  広島
- Year and Date
  2010-07-11
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] トランスポーターノックアウトマウス、in vitro系を用いた医薬品体内動態の解析:腎臓、脳に焦点をあてて2009
- Author(s)
  楠原洋之
- Organizer
  第2回Biomonthly Symposiumトランスポーターシンポジウム:トランスポーター研究の新たな展開
- Place of Presentation
  神戸
- Year and Date
  2009-06-02
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] MULTIPLICITY IN THE EFFLUX TRANSPORT SYSTEM FOR ORGANIC ANIONS AT THE BLOOD-BRAIN BARRIER2009
- Author(s)
  Kusuhara H, et al
- Organizer
  第31回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2009-12-01
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] Investigation of the efflux mechanisms of oseltamivir and its active form RO64-0802 across the blood-brain barrier2009
- Author(s)
  楠原洋之
- Organizer
  8th Cerebral Vascular Biology International Conference(招待講演)
- Place of Presentation
  仙台
- Year and Date
  2009-06-28
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] 抗インフルエンザ薬OSELTAMIVIRおよびその活性体RO64-0802の脳内濃度の個体間変動の解析2009
- Author(s)
  楠原洋之, 他
- Organizer
  第25回日本DDS学会
- Place of Presentation
  東京
- Year and Date
  2009-07-03
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] Role of Multidrug Resistance Associated Protein 3(MRP3/ABCC3)in the intestinal absorption of folic acid2009
- Author(s)
  楠原洋之, 他
- Organizer
  第5回武田科学振興財団薬科学シンポジウム"Bioactive Lipid Molecules and Transporters"
- Place of Presentation
  東京
- Year and Date
  2009-05-25
- Data Source
  KAKENHI-PROJECT-20014005
[Presentation] 医薬品の中枢応答性と血液脳関門における異物排泄2009
- Author(s)
  楠原洋之、杉山雄一
- Organizer
  日本薬学会
- Place of Presentation
  京都
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] トランスポーターノックアウトマウス、in vitro系を用いた医薬品体内動態の解析:腎臓、脳に焦点をあてて2009
- Author(s)
  楠原洋之
- Organizer
  第2回Biomonthly Symposiumトランスポーターシンポジウム:トランスポーター研究の新たな展開(招待講演)
- Place of Presentation
  神戸
- Year and Date
  2009-06-02
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] 肝・腎特異的な有機アニオントランスポーターの発現制御機構の解析2009
- Author(s)
  楠原洋之
- Organizer
  博多シンポジウム「内・外環境と生物応答」
- Place of Presentation
  福岡
- Year and Date
  2009-10-09
- Data Source
  KAKENHI-PROJECT-21659037
[Presentation] Multiplicity in the efflux transport system for organic anions at the blood-brain barrier2009
- Author(s)
  楠原洋之, 他
- Organizer
  第31回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2009-12-01
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] INVESTIGATION OF THE EFFLUX MECHANISMS OF OSELTAMIVIR AND ITS ACTIVE FORM RO64-0802 ACROSS THE BLOOD-BRAIN BARRIER2009
- Author(s)
  Kusuhara H
- Organizer
  8th Cerebral Vascular Biology International Conference
- Place of Presentation
  仙台
- Year and Date
  2009-06-28
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] SEARCH AND VALIDATION OF IN VIVO PROBE DRUGS FOR FUNCTIONAL ANALYSIS OF OAT1 AND OAT3 IN HUMANS2008
- Author(s)
  Tian Y, Maeda K, Kumagai Y, Kondo T, Kusuhara H and Sugiyama Y
- Organizer
  日本薬物動態学会第23回年会
- Place of Presentation
  熊本
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-20249008
[Presentation] Which determines the drug exposures in the plasma and liver? Uptake/efflux transporters or enzymes?2008
- Author(s)
  Sugiyama Y and Kusuhara H
- Organizer
  17th International Symposium on Microsomes and Drug Oxidations
- Place of Presentation
  Saratoga Springs, NY, USA
- Year and Date
  2008-07-06
- Data Source
  KAKENHI-PROJECT-20056005
[Presentation] ABCトランスポーターのノックアウトマウスを用いた医薬品体内動態の解析2008
- Author(s)
  楠原洋之
- Organizer
  トランスポーターワークショップ
- Place of Presentation
  山形
- Year and Date
  2008-11-15
- Data Source
  KAKENHI-PROJECT-20056005
[Presentation] Role of ABC transporters in Drug Absorption and Elimination2008
- Author(s)
  Kusuhara H.
- Organizer
  第4回日米合同薬学会議
- Place of Presentation
  名古屋
- Year and Date
  2008-02-22
- Data Source
  KAKENHI-PROJECT-18059007
[Presentation] 抗インフルエンザ薬oseltamivirおよびその活性代謝物Ro64-0802の血液脳関門を介Lた排出メカニズムの解析2008
- Author(s)
  楠原洋之他
- Organizer
  第29回日本臨床薬理学会年会
- Place of Presentation
  東京
- Year and Date
  2008-12-04
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] Role of Bcrp, Mrp3 and Mrp4 in drug disposition2008
- Author(s)
  Sugiyama Y., Kusuhara H
- Organizer
  FEBS-ABC2008、 March 4th
- Place of Presentation
  Innsbruck, Austria
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390046
[Presentation] 抗インフルエンザ薬oseltamivirおよびその活性代謝物Ro64-0802の血液脳関門を介した排出メカニズムの解析2008
- Author(s)
  楠原洋之, 他
- Organizer
  第29回日本臨床薬理学会年会
- Place of Presentation
  東京
- Year and Date
  2008-12-04
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] トランスポーターの発現による薬剤感受性の変動2008
- Author(s)
  楠原洋之
- Organizer
  日本薬物動態学会第22回ワークショップ
- Place of Presentation
  東京
- Year and Date
  2008-04-19
- Data Source
  KAKENHI-PROJECT-20056005
[Presentation] Role of Bcrp, Mrp3 and Mrp4 in drug disposition2008
- Author(s)
  Sugiyama Y. and Kusuhara H
- Organizer
  FEBS-ABC2008
- Place of Presentation
  Innsbruck, Austria
- Year and Date
  2008-03-04
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390046
[Presentation] Role of Bcrp,Mrp3 and Mrp4 indrug disposition2008
- Author(s)
  Sugiyama Y. and Kusuhara H
- Organizer
  FEBS-ABC2008
- Place of Presentation
  Innsbruck,Austria
- Year and Date
  2008-03-04
- Data Source
  KAKENHI-PROJECT-18390046
[Presentation] 医薬品の腎尿細管分泌機構と薬物トランスポーターを介した薬物間相互作用2008
- Author(s)
  楠原洋之
- Organizer
  第23回日本薬物動態学会年会
- Place of Presentation
  熊本
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-20056005
[Presentation] Role of Bcrp, Mrp3 and Mrp4 in drug disposition2008
- Author(s)
  Sugiyama Y. and Kusuhara H
- Organizer
  FEBS-ABC2008
- Place of Presentation
  Innsbruck, Austria
- Year and Date
  2008-03-04
- Data Source
  KAKENHI-PROJECT-18059007
[Presentation] Role of ABC transporters in Drug Absorption and Elimination2008
- Author(s)
  Kusuhara H.
- Organizer
  Pan-Pacific International Partnership Conference on Pharmaceutical and Life Sciences, February 22nd
- Place of Presentation
  Nagoya, Aichi, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390046
[Presentation] トランスポーターを利用した医薬品の中枢へのデリバリー2008
- Author(s)
  楠原洋之
- Organizer
  第24回日本DDS学会学術集会
- Place of Presentation
  東京
- Year and Date
  2008-06-29
- Data Source
  KAKENHI-PROJECT-20390046
[Presentation] Role of ABC transporters in Drug Absorption and Elimination2008
- Author(s)
  Kusuhara H.
- Organizer
  第4回日米合同薬学会議
- Place of Presentation
  名古屋
- Year and Date
  2008-02-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390046
[Presentation] 生体防御機構におけるABCトランスポーター(BCRPとMRP4)の機能解析2006
- Author(s)
  楠原洋之ほか
- Organizer
  第21回日本薬物動態学会年会
- Place of Presentation
  東京
- Year and Date
  2006-12-01
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209005
[Presentation] Species difference in the transport function of bile salt export pump (BSEP) between humans and rats2006
- Author(s)
  Hayashi H, et. al.
- Organizer
  The 14th Japanese Study Group for the Pathophysiology of the liver
- Place of Presentation
  Kyoto
- Year and Date
  2006-05-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209005
[Presentation] Functional Analyses of ABC transporters (BCRP and MRP4) in the detoxification of xenobiotics2006
- Author(s)
  Kusuhara H, et. al.
- Organizer
  The 21st JSSX Annual Meeting
- Place of Presentation
  Tokyo
- Year and Date
  2006-12-01
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209005
[Presentation] 肝臓のトランスポーターについて
- Author(s)
  楠原洋之、前田和哉
- Organizer
  第３１回日本TDM学会・学術大会
- Place of Presentation
  東京
- Year and Date
  2014-05-31 – 2014-06-01
- Invited
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] Quantitative Investigation of Drug Transport across the BBB
- Author(s)
  楠原　洋之
- Organizer
  CPSA Shanghai 2012
- Place of Presentation
  Shanghai, China
- Invited
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] トリメトプリムによる腎尿細管分泌における薬物間相互作用の解析
- Author(s)
  楠原洋之、鬼頭朋子、伊藤澄人
- Organizer
  日本薬剤学会第29年会
- Place of Presentation
  埼玉県大宮市
- Year and Date
  2014-05-20 – 2014-05-22
- Data Source
  KAKENHI-PROJECT-26293032
[Presentation] Impact of drug transporters on the interindividual difference in the pharmacokinetics/ pharmacodynamics of drugs; implication for predicting exposure of chemicals, and its effect
- Author(s)
  楠原洋之
- Organizer
  2014 ICCA-LRI & JRC Workshop
- Place of Presentation
  Lugano, Switzerland
- Year and Date
  2014-06-18 – 2014-06-19
- Invited
- Data Source
  KAKENHI-PROJECT-26293032
[Presentation] チアミンの体内動態におけるOCT1/2 および MATE の役割
- Author(s)
  加藤幸司、森山知洋、伊藤直樹、八馬賢次、萩間奈緒子、岩田勝也、山口順一、鈴木洋史、杉山雄一、楠原洋之
- Organizer
  日本薬剤学会第29年会
- Place of Presentation
  埼玉県大宮市
- Year and Date
  2014-05-20 – 2014-05-22
- Data Source
  KAKENHI-PROJECT-26293032
[Presentation] トランスポーターが関与する薬物間相互作用のパラメータ許容解分布推定法による解析
- Author(s)
  吉田健太、前田和哉、楠原洋之、小長谷明彦、杉山雄一
- Organizer
  第21回肝病態生理研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PLANNED-23136101
[Presentation] メタボロームによる薬物動態バイオマーカーの探索と薬物間相互作用の定量的解析への適用
- Author(s)
  楠原洋之
- Organizer
  第５回杉山特別研究室（理研）公開シンポジウム
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2015-02-09 – 2015-02-10
- Invited
- Data Source
  KAKENHI-PROJECT-26293032
[Presentation] Use of microdosing PET studies in new drug discovery and development: Development of PET probes for drug transporters
- Author(s)
  楠原　洋之
- Organizer
  Symposium on Functional and Molecular Imaging in Drug Discovery and Development
- Place of Presentation
  Soul, Korea
- Invited
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] 医薬品の体内動態特性を決定する生体膜輸送機構の解明
- Author(s)
  楠原洋之
- Organizer
  第57回日本薬学会関東支部大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] 薬物トランスポーターの種差と遺伝子多型による医薬品体内動態の個人間変動
- Author(s)
  楠原洋之
- Organizer
  第５４回日本先天異常学会学術集会
- Place of Presentation
  神奈川県相模原市
- Year and Date
  2014-07-26 – 2014-07-27
- Invited
- Data Source
  KAKENHI-PROJECT-26293032
[Presentation] 薬物トランスポーター機能解析に活かすＰＥＴイメージング：創薬への応用
- Author(s)
  楠原洋之
- Organizer
  第６回名古屋分子標的イメージングセミナー
- Place of Presentation
  名古屋
- Invited
- Data Source
  KAKENHI-PROJECT-23390034
[Presentation] Endogenous Probes for Evaluation of Drug- Drug Interactions Involving Renal Transporter
- Author(s)
  楠原洋之
- Organizer
  Experimental Biology 2015
- Place of Presentation
  Boston, USA
- Year and Date
  2015-03-28 – 2015-04-01
- Invited
- Data Source
  KAKENHI-PROJECT-26293032
[Presentation] 腎臓での薬物間相互作用の予測
- Author(s)
  楠原　洋之
- Organizer
  第332回CBI学会研究講演会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23390034
[]

1. SUGIYAMA Yuichi (80090471)

# of Collaborated Projects: 12 results

# of Collaborated Products: 52 results
2. SUZUKI Hiroshi (80206523)

# of Collaborated Projects: 9 results

# of Collaborated Products: 1 results
3. MAEDA Kazuya (00345258)

# of Collaborated Projects: 8 results

# of Collaborated Products: 34 results
4. HAYASHI Hisamitsu (10451858)

# of Collaborated Projects: 5 results

# of Collaborated Products: 5 results
5. Hibino Hiroshi (70314317)

# of Collaborated Projects: 5 results

# of Collaborated Products: 23 results
6. OGATA GENKI (80452829)

# of Collaborated Projects: 4 results

# of Collaborated Products: 23 results
7. 栄長泰明 (00322066)

# of Collaborated Projects: 4 results

# of Collaborated Products: 17 results
8. KATO Yukio (30251440)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. ONUKI Reko (70361607)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. 水野忠快 (90736050)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
11. HIRONO Shuichi (30146328)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. TAKIKAWA Hajime (70197226)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 椎木弘 (70335769)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. KUMAGAI Yuji (40215017)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. SUWA Toshio (20383664)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. WATANABE Yasuyosi (40144399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. KURACHI YOSHIHISA (30142011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. INOUE Ryuji (30232573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. YAMASHITA Fumiyoshi (30243041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. KITANO Hiroaki (80500256)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. OHTSUKI Sumio (60323036)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. AMANO Akira (60252491)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. KINOSHITA Kengo (60332293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. HARI Yoshiyuki (50347423)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. MAKITA Naomasa (00312356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. ISHIKAWA Yoshihiro (40305470)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. HONJO Haruo (70262912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. NAKAZAWA Kazuo (50198058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. OKUNO Yasushi (20283666)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. KAGECHIKA Hiroyuki (20177348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. HISAKA Akihiro (80420206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. ITO Kiyomi (60232435)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. NAGANO Tetsuo (20111552)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. SUGAWARA Yasuhiko (90313155)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. YOSHIZATO Katsutoshi (20095516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. SHITARA Yoshihisa (00306656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 家入一郎 (60253473)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
38. 藤田健一 (60281820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
39. 齋木琢郎 (90865057)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
40. 高井まどか (40287975)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. 稲生大輔 (40721981)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. 中村和昭 (80392356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. Kinoshita Setsuo

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
44. MULLER Micha

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. MELER J Pete

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
46. 千葉康司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. 花岡健二郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
48. 古川良明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. 伊藤澄人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kusuhara Hiroyuki 楠原 洋之

KUSUHARA Hiroyuki 楠原 洋之

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Construction of drug transport/metabolism research models by improving functions of human tissue-derived cellsPrincipal Investigator

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Pharmacokinetic study on transporters in the xenobiotic detoxification among the liver, small intestine and kidneyPrincipal Investigator

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Development of lead optimization method using novel profile data analysis methodPrincipal Investigator

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Development of deep phenotyping method that enables analysis and application of latent drug responsePrincipal Investigator

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Exploration study to identify pharmacokinetic biomarkers by pharmacometabolomic approachesPrincipal Investigator

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Development of a comprehensive drug transporter identification method by gene knockoutPrincipal Investigator

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Elucidation of the importance of novel transporters in the disposition of cationic drugsPrincipal Investigator

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Comprehensive analysis of endogenous compounds applicable to in vivo evaluation of drugs transportersPrincipal Investigator

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Comprehensive analysis of the factors regulating the disposition of small molecules at organ and tissue levelsPrincipal Investigator

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Kusuhara Hiroyuki 楠原洋之

KUSUHARA Hiroyuki 楠原洋之