Sakurai Hiroaki 櫻井宏明

… Alternative Names

SAKURAI Hiroaki 櫻井宏明

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Researcher Number	00345571
Other IDs
Affiliation (Current)	2023: 富山大学, 学術研究部薬学・和漢系, 教授
Affiliation (based on the past Project Information) *help	2019 – 2022: 富山大学, 学術研究部薬学・和漢系, 教授 2011 – 2018: 富山大学, 大学院医学薬学研究部(薬学), 教授 2012: 富山大学, 和漢医薬学総合研究所, 准教授 2011: 富山大学, 大学院・医学薬学研究部(薬学), 教授 2007 – 2010: University of Toyama, Institute of Natural Medicine, Associate Professor … More 2006: 富山大学, 助教授 2005 – 2006: 富山大学, 和漢医薬学総合研究所, 助教授 2003 – 2004: 富山医科薬科大学, 和漢薬研究所, 助教授 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Biological Sciences / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Drug development chemistry / Tumor biology Except Principal Investigator Biological Sciences / Clinical oncology / Radiation science / General internal medicine (including Psychosomatic medicine) / Applied biochemistry
Keywords	Principal Investigator TAK1 / がん / リン酸化 / EGFR / TNF-α / シグナル伝達 / NF-κB / キナーゼ / 受容体 / EphA2 … More / MAPK / TAB1 / TAB2 / IKK / TNF / 炎症 / チロシンキナーゼ / がん転移 / TRAIL / 増殖因子 / 細胞 / 癌 / metastasis / ストレスシグナル / p65 / Ser-536 / SerpinE2 / EGF / p38 / ERK / ERbB3 / クロストーク / 漢方薬 / 生薬 / Kinome / ケミカルバイオロジー / 細胞内情報伝達 / ライブラリー / スクリーニング / ErbB / チロシンキナーゼ型受容体 / RSK / Helicobacter pylori / 肺がん / がん微小環境 / アポトーシス / IL-2 / T細胞 / apoptosis / 小胞輸送 / 代謝 / グルコース / Nrf2 / 糖 / 細胞遊走 / 病態 / 治療 … More Except Principal Investigator ケモカイン / chronic hypoperfusion / cognitive deficit / Kampo Medicine / chotosan / endogenous factor(s) / cholinergic system / gene expression / experimental ischemia / atrophy / neuron / skeletal muscle / 肺がん / リンパ節転移 / ドラッグデリバリー / がん細胞 / 遊走 / 方向性 / がん / ＴＡＫ１ / 放射線 / 温熱 / 細胞死 / アポトーシス / TAK1 / macrophage colony刺激因子 / gene analysis / saikokeishito / special cognitive deficit / glycerophosphodiester / glycerophosphoinositol / skeleatal muscle / outgrowth / 筋萎縮 / グリセロホスホジエステル / GDE / insulin resistance / glyceronhosphodiester / glvcerophosphoinositol Less

Cancer pathophysiology and treatment from the perspective of dual-mode control of EGFRPrincipal Investigator
- Principal Investigator
  
  櫻井宏明
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  University of Toyama
Alternative activation mechanisms of receptor tyrosine kinases in inflammation-induced cancer progressionPrincipal Investigator
- Principal Investigator
  
  SAKURAI Hiroaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  University of Toyama
Noncanonical activation of receptor tyrosine kinases: next target mechanisms for cancer progressionPrincipal Investigator
- Principal Investigator
  
  Hiroaki Sakurai
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  University of Toyama
Functional interactions between inflammatory signal and growth singaling in the Warburg effect in cancer cellsPrincipal Investigator
- Principal Investigator
  
  Hiroaki Sakurai
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Toyama
Effects of a TAK1 inhibitor on radiation-and heat-induced cell killing
- Principal Investigator
  
  KONDO Takashi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  University of Toyama
炎症シグナルによるＥｒｂＢチロシンキナーゼのＳｅｒ／Ｔｈｒリン酸化とがん悪性化Principal Investigator
- Principal Investigator
  
  櫻井宏明
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Toyama
Role of TNF-TAK1 signaling pathway in tumor microenvironments of metastasisPrincipal Investigator
- Principal Investigator
  
  SAKURAI Hiroaki
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Toyama
Development of DDS which accumulate cancer cell by chemokines function in peritoneal carcinomatosis therapy
- Principal Investigator
  
  KOIZUMI Keiichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  University of Toyama
Kampo-Kinome解析によるケミカルバイオロジーの展開Principal Investigator
- Principal Investigator
  
  櫻井宏明
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  University of Toyama
ROLE OF TAK1 IN CROSS INTERFERENCE BETWEEN TNF-α AND EGF SIGNALING PATHWAYSPrincipal Investigator
- Principal Investigator
  
  SAKURAI Hiroaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Toyama
Isolation and characterization of mammalian glycerophosphodiester phosphodiesterases
- Principal Investigator
  
  YANAKA Noriyuki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied biochemistry
- Research Institution
  Hiroshima University
Search, identification, and functional analysis of target molecules for cerebrovascular dementia treatment using bioactivities of Kampo medicines
- Principal Investigator
  
  MATSUMOTO Kinzo
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  University of Toyama
Molecular mechanism of metastasis promoting activity of stress response kinase TAK1Principal Investigator
- Principal Investigator
  
  SAKURAI Hiroaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Toyama
NF-κB活性化シグナルにおけるp65リン酸化の果たす役割Principal Investigator
- Principal Investigator
  
  櫻井宏明
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Toyama Medical and Pharmaceutical University
がん細胞のリンパ節転移に関与するケモカイン及び受容体の探索と分子標的治療への応用
- Principal Investigator
  
  SAIKI Ikuo
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Toyama Medical and Pharmaceutical University
ストレスシグナル伝達分子TAK1の病態制御分子としての役割Principal Investigator
- Principal Investigator
  
  櫻井宏明
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Toyama Medical and Pharmaceutical University

[Book] 酸化ストレスの医学, 改訂第２版2014
- Author(s)
  近藤　隆, 櫻井宏明, 田渕圭章
- Total Pages
  8
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-26670551
[Book] Therapeutics target of CXCR4 and its downstream in peritoneal carcinomatosis of gastric cancer2012
- Author(s)
  Koizumi K., Kato S., Sakurai H., Hashimoto I., Yasumoto K., and Saiki I
- Publisher
  Front Biosci (Schol Ed)
- Data Source
  KAKENHI-PROJECT-22501042
[Journal Article] New trend in ligand-induced EGFR trafficking: A dual-mode clathrin-mediated endocytosis model2022
- Author(s)
  Zhou Yue、Sakurai Hiroaki
- Journal Title
  
  Journal of Proteomics
  
  Volume: 255 Pages: 104503-104503
- DOI
  10.1016/j.jprot.2022.104503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03368
[Journal Article] RSK-Mediated Non-canonical Activation of EphA2 by Tamoxifen2022
- Author(s)
  Yonehara Keisuke、Zhou Yue、Takahashi Jun-ichiro、Yokoyama Satoru、Tomihara Kei、Noguchi Makoto、Sakurai Hiroaki
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 45 Issue: 2 Pages: 162-168
- DOI
  10.1248/bpb.b21-00567
- NAID
  130008150238
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03368
[Journal Article] Mechanism of p38 MAPK-induced EGFR endocytosis and its crosstalk with ligand-induced pathways2021
- Author(s)
  Perez Verdaguer Mireia、Zhang Tian、Paulo Joao A.、Gygi Steven、Watkins Simon C.、Sakurai Hiroaki、Sorkin Alexander
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 220
- DOI
  10.1083/jcb.202102005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03368
[Journal Article] Temozolomide Induces Endocytosis of EGFRvIII <i>via</i> p38-Mediated Non-canonical Phosphorylation in Glioblastoma Cells2021
- Author(s)
  Haryuni Ratna Dini、Tanaka Tomohiro、Takahashi Jun-ichiro、Onuma Iimi、Zhou Yue、Yokoyama Satoru、Sakurai Hiroaki
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 44 Issue: 11 Pages: 1681-1687
- DOI
  10.1248/bpb.b21-00371
- NAID
  130008110308
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03368
[Journal Article] A new mechanism of EGFR activation identified by Phos-tag band shift analysis2020
- Author(s)
  Tanaka Tomohiro、Zhou Yue、Sakurai Hiroaki
- Journal Title
  
  Electrophoresis Letters
  
  Volume: 64 Issue: 1 Pages: 45-48
- DOI
  10.2198/electroph.64.45
- NAID
  130007871301
- ISSN
  2189-2628, 2189-2636
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03368
[Journal Article] Rational combination therapy for melanoma with dinaciclib by targeting BAK-dependent cell death.2020
- Author(s)
  Xu Xiaoou、Eshima Shizuka、Kato Shinichiro、Fisher David E.、Sakurai Hiroaki、Hayakawa Yoshihiro、Yokoyama Satoru
- Journal Title
  
  Mol. Cancer Ther.
  
  Volume: 19 Pages: 627-636
- DOI
  10.1158/1535-7163.mct-19-0451
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07227, KAKENHI-PLANNED-17H06398, KAKENHI-PROJECT-19H03368
[Journal Article] ERK?mediated negative feedback regulation of oncogenic EGFRvIII in glioblastoma cells2020
- Author(s)
  Haryuni Ratna、Tanaka Tomohiro、Zhou Yue、Yokoyama Satoru、Sakurai Hiroaki
- Journal Title
  
  Oncology Letters
  
  Volume: 20 Pages: 2477-2482
- DOI
  10.3892/ol.2020.11760
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03368, KAKENHI-PROJECT-18K07227
[Journal Article] Activation of receptor tyrosine kinases from inside of the cell2020
- Author(s)
  周越、櫻井宏明
- Journal Title
  
  生化学
  
  Volume: 92 Issue: 3 Pages: 420-430
- DOI
  10.14952/SEIKAGAKU.2020.920420
- NAID
  40022295378
- ISSN
  0037-1017
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03368, KAKENHI-PROJECT-19K23795
[Journal Article] Negative feedback regulation of ErbB4 tyrosine kinase activity by ERK-mediated non-canonical phosphorylation2019
- Author(s)
  Haryuni R.D., Watabe S., Yamaguchi A., Fukushi Y., Tanaka T., Kawasaki Y., Zhou Y., Yokoyama S., and Sakurai H.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04694
[Journal Article] Cisplatin-induced non-canonical endocytosis of EGFR via p38 phosphorylation of the C-terminal region containing Ser-1015 in non-small cell lung cancer cells2018
- Author(s)
  Tanaka T, Ozawa T, Oga E, Muraguchi A, Sakurai H.
- Journal Title
  
  Oncol. Lett.
  
  Volume: 15 Pages: 9251-9256
- DOI
  10.3892/ol.2018.8485
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04694
[Journal Article] Ligand-activated epidermal growth factor receptor (EGFR) signaling governs endocytic trafficking of unliganded receptor monomers by non-canonical phosphorylation2018
- Author(s)
  Tanaka T, Zhou Y, Ozawa T, Okizono R, Banba A, Yamamura T, Oga E, Muraguchi A, Sakurai H.
- Journal Title
  
  J Biol Chem
  
  Volume: 293 Pages: 2288-2301
- DOI
  10.1074/jbc.m117.811299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04694, KAKENHI-PROJECT-15K09522
[Journal Article] Non-canonical Activation of Receptor Tyrosine Kinases in Cancer Progression2017
- Author(s)
  櫻井宏明
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 137 Issue: 2 Pages: 141-144
- DOI
  10.1248/yakushi.16-00229-4
- NAID
  130005305795
- ISSN
  0031-6903, 1347-5231
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04694
[Journal Article] Two different mechanisms for chemotherapeutic agent-induced inactivation of ErbB2 and ErbB3 via ERK and p38 pathways in breast cancer cells.2017
- Author(s)
  Park C.M., Kawasaki Y., Refaat A., and Sakurai H.
- Journal Title
  
  Oncology Letters
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H04694
[Journal Article] Bardoxolone-methyl inhibits migration and metabolism in MCF7 cells.2017
- Author(s)
  Refaat A., Pararasa C., Arif M., Brown J.E.P., Carmichael A., Ali S.S., Sakurai H., Griffiths H.R.
- Journal Title
  
  Free Radic Res
  
  Volume: 51 Pages: 211-221
- DOI
  10.1080/10715762.2017.1295452
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04694, KAKENHI-PROJECT-16K15117
[Journal Article] Emerging and Diverse Functions of the EphA2 Noncanonical Pathway in Cancer Progression2017
- Author(s)
  Zhou Y, Sakurai H.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 40 Issue: 10 Pages: 1616-1624
- DOI
  10.1248/bpb.b17-00446
- NAID
  130006110586
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04694
[Journal Article] P38 pathway as a key downstream signal of connective tissue growth factor to regulate metastatic potential in non-small-cell lung cancer.2016
- Author(s)
  Kato S., Yokoyama S., Hayakawa Y., Luhui L., Iwakami Y., Sakurai H., and Saiki I.
- Journal Title
  
  Cancer Sci.
  
  Volume: 107 Pages: 1416-1421
- DOI
  10.1111/cas.13009
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04694, KAKENHI-PROJECT-15K08902, KAKENHI-PROJECT-16K18413
[Journal Article] Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain.2016
- Author(s)
  Kawasaki Y, Sakimura A, Park CM, Tomaru R, Tanaka T, Ozawa T, Zhou Y, Narita K, Kishi H, Muraguchi A, Sakurai H
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Pages: 31502-31502
- DOI
  10.1038/srep31502
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06499, KAKENHI-PROJECT-16H04694, KAKENHI-PROJECT-15K09522, KAKENHI-PROJECT-16K08366
[Journal Article] Helicobacter pylori Induces Serine Phosphorylation of EGFR via Novel TAK1-p38 Activation Pathway in an HB-EGF-Independent Manner.2015
- Author(s)
  Zaidi S.F., Refaat A., Zhou Y., Muhammad J.S., Shin M.S., Saiki I., Sakurai H., and Sugiyama T.
- Journal Title
  
  Helicobacter
  
  Volume: 印刷中 Pages: 381-389
- DOI
  10.1111/hel.12215
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23590071, KAKENHI-PROJECT-15K08902
[Journal Article] Role of tyrosine kinase-independent phosphorylation of EGFR with activating mutation in cisplatin-treated lung cancer cells.2015
- Author(s)
  Refaat A., Aminullah, Zhou Y., Kawanishi M., Tomaru R., Abdelhamed S., Shin M.S., Koizumi K., Yokoyama S., Saiki I., and Sakurai H.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 458 Pages: 856-861
- DOI
  10.1016/j.bbrc.2015.02.044
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23590071, KAKENHI-PROJECT-24659348, KAKENHI-PROJECT-24700971
[Journal Article] p38-mediated phosphorylation of Eps15 endocytic adaptor protein2014
- Author(s)
  Zhou Y., Tanaka T., Sugiyama N., Yokoyama S., Kawasaki Y., Sakuma T., Ishihama Y., Saiki I., and Sakurai H.
- Journal Title
  
  FEBS Lett
  
  Volume: 588 Pages: 131-137
- DOI
  10.1016/j.febslet.2013.11.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590071, KAKENHI-PROJECT-23590172, KAKENHI-PUBLICLY-24116513, KAKENHI-PROJECT-24241062, KAKENHI-PROJECT-24659017, KAKENHI-PROJECT-24659348, KAKENHI-PROJECT-24700971
[Journal Article] Mesenchymal-transitioned cancer cells instigate epithelial cancer cells to metastasis through secretion of WNT3 and WNT5B.2014
- Author(s)
  Kato S, Hayakawa Y, Sakurai H, Saiki I, Yokoyama S
- Journal Title
  
  Cancer Sci.
  
  Volume: 105 Pages: 281-289
- DOI
  10.1111/cas.12336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J10159, KAKENHI-PROJECT-23590071, KAKENHI-PROJECT-24659348, KAKENHI-PROJECT-24700971
[Journal Article] Chemokine CXCL16 suppresses liver metastasis of colorectal cancer via augmentation of tumor-infiltrating NKT cells in a murine model2013
- Author(s)
  Ji-Ye Kee, Aya Ito, Shozo Hojo, Isaya Hashimoto, Yoshiko Igarashi, Kazuhiro Tsukada, Tatsuro Irimura, Naotoshi Shibahara, Takashi Nakayama, Osamu Yoshie, Hiroaki Sakurai, Ikuo Saiki and Keiichi Koizumi
- Journal Title
  
  Oncol.Rep
  
  Volume: 29 Pages: 975-82
- Data Source
  KAKENHI-PROJECT-22501042
[Journal Article] Inverse correlation between Thr-669 and constitutive tyrosine phosphorylation in the asymmetric epidermal growth factor receptor dimer conformation.2013
- Author(s)
  Sato K., Shin M.S., Sakimura A., Zhou Y., Tanaka T., Kawanishi M., Kawasaki Y., Yokoyama S., Koizumi K., Saiki I., and Sakurai H.
- Journal Title
  
  Cancer Sci.
  
  Volume: 104 Pages: 1315-1322
- DOI
  10.1111/cas.12225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590071, KAKENHI-PROJECT-24659348, KAKENHI-PROJECT-24700971
[Journal Article] チロシンキナーゼ型受容体のセリン／トレオニンリン酸化制御2013
- Author(s)
  周越、田中智大、櫻井宏明
- Journal Title
  
  日本生化学会誌「生化学」
  
  Volume: 85 Pages: 462-468
- NAID
  10031184267
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590071
[Journal Article] Tuning of protein kinase circuitry by p38α is vital for epithelial tissue homeostasis.2013
- Author(s)
  Caballero-Franco C., Choo M.K., Sano Y., Ritprajak P., Shim J.H., Sakurai H., Otsu K., Glimcher L.H., Mizoguchi A., and Park J.M.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 288 Pages: 23788-23797
- DOI
  10.1074/jbc.m113.452029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590071
[Journal Article] Targeting of TAK1 in inflammatory disorders and cancer.2012
- Author(s)
  Sakurai H.
- Journal Title
  
  Trends Pharmacol. Sci.
  
  Volume: 35 Pages: 522-530
- DOI
  10.1016/j.tips.2012.06.007
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23117516
[Journal Article] Anti-tumor immune activity by chemokine CX3CL1 in an orthotopic implantation of lung cancer model in vivo2012
- Author(s)
  Kee J-Y,Arita Y, Shinohara K,Ohasgi Y, Sakurai H, Saiki I, Koizumi K
- Journal Title
  
  Mol. Clin. Oncol
- Data Source
  KAKENHI-PROJECT-22501042
[Journal Article] Calpain 1 and -2 play opposite roles in cord formation of lymphatic endotherial cells via eNOS regulation2012
- Author(s)
  Prangsaengtong O, Senda K, Doki Y, Park J-Y, Jo M, Sakurai H, Shibahara N, Saiki I, and Koizumi K
- Journal Title
  
  Human Cell
  
  Volume: 25 Pages: 36-44
- Data Source
  KAKENHI-PROJECT-22501042
[Journal Article] Gomisin A Enhances Tumor Necrosis Factor-α-Induced G1 Cell Cycle Arrest <i>via</i> Signal Transducer and Activator of Transcription 1-Mediated Phosphorylation of Retinoblastoma Protein2012
- Author(s)
  Waiwut P., Shin M.S., Yokoyama S., Saiki I., and Sakurai H.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 35 Issue: 11 Pages: 1997-2003
- DOI
  10.1248/bpb.b12-00450
- NAID
  130001872260
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590071
[Journal Article] TGF-beta-activated kinase 1 promotes cell cycle arrest and cell survival of X-ray-irradiated HeLa cells dependent on p21 induction but independent of NF-κB, p38 MAPK and ERK phosphorylations.2012
- Author(s)
  Furusawa Y., Wei Z.L., Sakurai H., Tabuchi Y., Li P., Zhao Q.L., Nomura T., Saiki I., and Kondo T.
- Journal Title
  
  Radiat. Res.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590071
[Journal Article] Distinct Roles of Transforming Growth Factor-{beta}-activated Kinase 1 (TAK1)-c-Rel and Interferon Eegulatory Factor 4 (IRF4) Pathways in Human T Cell Lymphotropic Virus 1-transformed T helper 17 Cells Producing Interleukin-92011
- Author(s)
  Refaat A., Zhou Y., Suzuki S., Takasaki I., Koizumi K., Yamaoka S., Tabuchi Y., Saiki I., Sakurai H.
- Journal Title
  
  J Biol Chem.
  
  Volume: 286 Pages: 21092-21099
- DOI
  10.1074/jbc.m110.200907
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23117516, KAKENHI-PROJECT-23390386
[Journal Article] Identification and functional characterization of a novel phosphorylation sites in TAK1-binding protein (TAB) 1.2011
- Author(s)
  Wolf A., Beuerlein K., Eckart C., Weiser H., Dickkopf B., Müller H., Sakurai H., and Kracht M.
- Journal Title
  
  PLoS ONE
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590071
[Journal Article] eNOS and Hsp90 interaction directly correlates with the cord formation in human lymphatic endothelial cells2011
- Author(s)
  Prangsaengtong O., Koizumi K., Senda K., Sakurai H., and Saiki I.
- Journal Title
  
  Lymphat. Res. Biol
  
  Volume: 9 Pages: 53-59
- Data Source
  KAKENHI-PROJECT-22501042
[Journal Article] Distinct roles of TAK1-c-Rel and IRF4 pathways in HTLV-1-transformed Th17 cells producing IL-9.J2011
- Author(s)
  Refaat A., Zhou Y., Suzuki S., Takasaki I., Koizumi K., Yamaoka S., Tabuchi Y., Saiki I., and Sakurai H
- Journal Title
  
  Biol. Chem
  
  Volume: 286 Pages: 21092-21099
- Data Source
  KAKENHI-PROJECT-22501042
[Journal Article] Activation of NF-κB is a novel target of KRAS-induced endometrial carcinogenesis2011
- Author(s)
  Mizumoto Y, Kyo S, Kiyono T, Takakura M, Nakamura M, Maida Y, Nori N, Bono Y, Sakurai H, Inoue M
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 17(6) Pages: 1341-1350
- DOI
  10.1158/1078-0432.ccr-10-2291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791520, KAKENHI-PUBLICLY-23117516, KAKENHI-PROJECT-23701097
[Journal Article] Human T cell lymphotropic virus 1 manipulates interferon regulatory signals by controlling the TAK1-IRF3 and IRF4 pathways.J2010
- Author(s)
  Suzuki S., Zhou Y., Refaat A., Takasaki I., Koizumi K., Yamaoka S., Tabuchi Y., Saiki I., and Sakurai H
- Journal Title
  
  Biol. Chem
  
  Volume: 285 Pages: 4441-4446
- Data Source
  KAKENHI-PROJECT-22501042
[Journal Article] An F-box protein FBXW5 negatively regulates TAK1 MAPKKK in the IL-1β signaling pathway2009
- Author(s)
  Minoda Y., Sakurai H., Kobayashi T., Yoshimura A., and Takaesu G.
- Journal Title
  
  Biochem. Biophys. Res. Commun 381
  
  Pages: 412-417
- Data Source
  KAKENHI-PROJECT-19590063
[Journal Article] Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells2008
- Author(s)
  Ueno Y., Sakurai H., Tsunoda S., Matsuo M., Choo M.K., Koizumi K., and Saiki I.
- Journal Title
  
  Int. J. Cancer 123
  
  Pages: 340-347
- Data Source
  KAKENHI-PROJECT-19590063
[Journal Article] Epoxyquinol B, a naturally occurring pentaketide dimer, inhibits NF--B signaling by crosslinking TAK12008
- Author(s)
  Kamiyama H., Usui T., Sakurai H., Shoji M., Hayashi Y., Kakeya H., and Osada H.
- Journal Title
  
  Biosci. Biotechnol. Biochem 72
  
  Pages: 1894-1900
- Data Source
  KAKENHI-PROJECT-19590063
[Journal Article] Transient suppression of ligand-mediated activation of epidermal growth factor receptor by TNF-αthrough the TAK1-p38 signaling pathway2007
- Author(s)
  Singhirunnusorn P., Ueno Y., Matsuo M., Suzuki S., Saiki I., and Sakurai H.
- Journal Title
  
  J. Biol. Chem 282
  
  Pages: 12698-12706
- Data Source
  KAKENHI-PROJECT-19590063
[Journal Article] Constitutive activation of TAK1 by HTLV-1 Tax-dependent overexpression of TAB2 induces activation of JNK-ATF22007
- Author(s)
  Suzuki S., Singhirunnusorn P., Mori A., Yamaoka S., Kitajima I., Saiki I., and Sakurai H.
- Journal Title
  
  but not IKK-NF-κB. J. Biol. Chem 282
  
  Pages: 25177-25181
- Data Source
  KAKENHI-PROJECT-19590063
[Journal Article] TAK1-mediated transcriptional activation of CD28-responsive element and AP-1 site within the IL-2 promoter in Jurkat T cells.2005
- Author(s)
  Sakurai H. et al.
- Journal Title
  
  FEBS Lett. 579 (29)
  
  Pages: 6641-6646
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590055
[Journal Article] TAK1-mediated transcriptional activation of CD28-responsive element and AP-1 site within the IL-2 promoter in Jurkat T cells.2005
- Author(s)
  Sakurai et al.
- Journal Title
  
  FEBS Lett. 579(29)
  
  Pages: 6641-6646
- Data Source
  KAKENHI-PROJECT-17590055
[Journal Article] TAK1-mediated transcriptional activation of CD28-responsive element and AP-1 site within the IL-2 promoter in Jurkat T cells.2005
- Author(s)
  Sakurai H. et al.
- Journal Title
  
  FEBS Lett. 579(29)
  
  Pages: 6641-6646
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590055
[Journal Article] Cross interference with TNF-α-induced TAK1 activation via EGFR mediated p38 phosphorylation of TAK1-binding protein 1
- Author(s)
  Shin M.S., Singhirunnusorn P., Sugishima Y., Nishimura M., Suzuki S., Koizumi K., Saiki I., and Sakurai H.
- Journal Title
  
  Biochim. Biophys (Acta in press)
- Data Source
  KAKENHI-PROJECT-19590063
[Journal Article] Suppression of cell invasiveness by periostin via TAB1/TAK1
- Author(s)
  Isono T., Kim C.J., Ando Y., Sakurai H., Okada Y., Inoue H.
- Journal Title
  
  Int. J. Oncol (in press)
- Data Source
  KAKENHI-PROJECT-19590063
[Patent] 3.抗体のエンドサイトーシスを促進するための方策2022
- Inventor(s)
  櫻井宏明
- Industrial Property Rights Holder
  櫻井宏明
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-028554
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-19H03368
[Patent] 抗体のエンドサイトーシスを促進するための方策2021
- Inventor(s)
  櫻井宏明
- Industrial Property Rights Holder
  櫻井宏明
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-030391
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] MK2を介した非定型的RSK-EphA2経路の制御機構2022
- Author(s)
  周越、大木良太、田中章裕、横山悟、櫻井宏明
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] Efficient endocytosis of the cetuximab EGFR complex via p38-mediated non-canonical phosphorylation2021
- Author(s)
  高橋隼一郎, 周越, 横山悟, 櫻井宏明
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] ストレス応答キナーゼp38とMK2を介したRSK-EphA2経路の活性化2021
- Author(s)
  周越、大木良太、田中章裕、横山悟、櫻井宏明
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] p38 を介した Cetuximab-EGFR 複合体の効率的なエンドサイトーシス2021
- Author(s)
  高橋隼一郎，中村施央里，周　越，横山　悟，櫻井宏明
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] ストレス応答キナーゼp38を介したEphA2リン酸化制御2021
- Author(s)
  田中章裕、大木良太、周越、横山悟、櫻井宏明
- Organizer
  第21回 Pharmaco-Hematologyシンポジウム
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] RSK-EphA2経路の活性化におけるストレスキナーゼp38とMK2の役割2021
- Author(s)
  周越、横山悟、矢野聖二、櫻井宏明
- Organizer
  第25回日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] 酸化ストレスによるTAB1チロシンリン酸化の分子機構2021
- Author(s)
  大沼逸美，岩田悠輔，岩原宏幸，中田真衣，名取香奈子，周越，横山悟，櫻井宏明
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] ストレス応答キナーゼp38とMK2はRSK-EphA2経路の活性化を誘導することで細胞遊走を促進する2021
- Author(s)
  周越、大木良太、田中章裕、横山悟、矢野聖二、櫻井宏明
- Organizer
  第30回日本がん転移学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] 細胞内ストレスによる p38-MK2-RSK 経路を介した EphA2 リン酸化2021
- Author(s)
  田中章裕、大木良太、周越、横山悟、櫻井宏明
- Organizer
  日本生化学会北陸支部第39回大会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] p38-MK2-RSKを介したEphA2の非定型的活性化制御2021
- Author(s)
  周越，大木良太，田中章裕，山畑伊織，横山悟，櫻井宏明
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] 大気汚染物質9,10-phenanthrenequinoneによるチロシンキナーゼ型受容体の非定型的リン酸化2021
- Author(s)
  山岸奈央、高橋隼一郎、周越、横山悟、櫻井宏明
- Organizer
  フォーラム2021 衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] 大気汚染物質9,10-PQによるチロシンキナーゼ型受容体の非定型的リン酸化2021
- Author(s)
  山岸奈央，高橋隼一郎，周越，横山悟，櫻井宏明
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] 悪性黒色腫におけるSOX10を介したPD-L1発現制御機構2021
- Author(s)
  高橋篤司，早川芳弘，櫻井宏明，横山悟
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] Cetuximab-EGFR複合体の効率的なエンドサイトーシスの解析2021
- Author(s)
  高橋隼一郎、櫻井宏明、周越、横山悟
- Organizer
  第25回日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] Non-canonical phosphorylation of EphA2 via the stress-induced p38-MK2 pathway2021
- Author(s)
  田中章裕、周越、横山悟、櫻井宏明
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] PTEN欠損によるBRAFV600E変異依存的な細胞運動亢進2021
- Author(s)
  安田裕敬，周越，櫻井宏明，横山悟
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] SOX10 negatively regulates PD-L1 expression in melanoma2020
- Author(s)
  Satoru Yokoyama, Atsushi Takahashi, Yue Zhou, Yoshihiro Hayakawa, Hiroaki Sakurai
- Organizer
  第79回　日本癌学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] Non-canonical activation of EphA2 induces cell migration via Rab11 and Rab11-FIP1.2020
- Author(s)
  周越、山畑伊織、山村朋弘、横山悟、櫻井宏明
- Organizer
  第29回日本がん転移学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] Regulation of cancer cell malignancy via MK2-RSK-EphA2 axis.2020
- Author(s)
  Yue Zhou, Ryota Oki, Iori Yamahata, Satoru Yokoyama, Sakurai Hiroaki
- Organizer
  第79回　日本癌学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] SrcによるTAB1リン酸化: 酸化ストレスの新しいシグナル経路2020
- Author(s)
  岩原宏幸、岩田悠輔、名取香奈子、小澤龍彦、周越、定清直、横山悟、櫻井宏明
- Organizer
  フォーラム2020　衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] ストレス応答キナーゼp38によるRSK-EphA2経路の制御機構2020
- Author(s)
  周越、横山悟、櫻井宏明
- Organizer
  第24回日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] 悪性黒色腫におけるSOX10を介したPD-L1の発現制御機構2020
- Author(s)
  高橋篤司、横山悟、早川芳弘、櫻井宏明
- Organizer
  第24回日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] Regulation of cancer cell motility via p38-MK2-RSK-EphA2 axis．2020
- Author(s)
  周越、大木良太、田中章裕、山畑伊織、、横山悟、櫻井宏明
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] 悪性黒色腫におけるSOX10を介したPD-L1発現制御機構2020
- Author(s)
  高橋篤司、早川芳弘、櫻井宏明、横山悟
- Organizer
  第19回次世代を担う若手のためのファーマ・バイオフォーラム2020
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] ErbB2/3ヘテロダイマーにおける新たな非定型的リン酸化部位の同定2019
- Author(s)
  地子愛佳里，池ヶ谷真吾，馬場絢子，河崎優希，周越，櫻井宏明
- Organizer
  日本薬学会北陸支部第131回例会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] がん悪性化におけるセリン/スレオニンキナーゼによるチロシンキナーゼ型受容体の活性化2019
- Author(s)
  櫻井宏明
- Organizer
  日本薬学会第139年会
- Invited
- Data Source
  KAKENHI-PROJECT-16H04694
[Presentation] STAMBPは、SLUGタンパク質の安定性を調節し、悪性黒色腫の転移を制御する2019
- Author(s)
  横山悟，岩上雄亮，櫻井宏明，早川芳弘
- Organizer
  第28回日本がん転移学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] RSK-EphA2経路によって誘導される細胞遊走はRab11とRab11-FIP1に依存する2019
- Author(s)
  周越，山畑伊織，山村朋弘，横山悟，櫻井宏明
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] CDK2/9阻害剤DinaciclibによるBAKを介した抗悪性黒色腫効果と新規併用療法の提案2019
- Author(s)
  横山悟，早川芳弘，櫻井宏明
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] 白斑誘導物質ロドデノールによる抗悪性黒色腫効果の検討2019
- Author(s)
  横山悟，早川芳弘，櫻井宏明
- Organizer
  フォーラム2019 衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] Phos-tag解析から見えてきた新しいEGFR活性化機構2019
- Author(s)
  櫻井宏明
- Organizer
  日本プロテオーム学会2019年大会・第70回日本電気泳動学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] GIST細胞におけるRSK阻害剤BI-D1870のKIT発現抑制による細胞増殖抑制効果2019
- Author(s)
  石田勝也，福司弥生，周越，横山悟，櫻井宏明
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] 悪性黒色腫におけるSOX10を介したPD-L1の発現制御機構2019
- Author(s)
  佐藤弘樹，高橋篤司，横山悟，櫻井宏明
- Organizer
  日本薬学会北陸支部第131回例会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] 非定型的活性型EphA2による細胞遊走促進は小胞遊走関連タンパクRab11に依存する2019
- Author(s)
  周越，山畑伊織，山村朋弘，横山悟，櫻井宏明
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] 消化管間質腫瘍細胞におけるRSK阻害剤BI-D1870のKIT発現抑制による細胞増殖抑制効果2019
- Author(s)
  石田勝也，福司弥生，周越，横山悟，櫻井宏明
- Organizer
  日本薬学会北陸支部第131回例会
- Data Source
  KAKENHI-PROJECT-19H03368
[Presentation] 上皮間葉転換に伴うEphA2の発現および局在化機構2018
- Author(s)
  山村朋弘, 山畑伊織，田中智大，周越，櫻井宏明
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H04694
[Presentation] 大腸がんにおけるMEK/ERK経路を介したKITの発現制御機構2018
- Author(s)
  福司弥生，齋藤正英，櫻井宏明
- Organizer
  第22回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16H04694
[Presentation] がんの悪性化進展におけるチロシンキナーゼ型受容体の非触媒機能2018
- Author(s)
  櫻井宏明
- Organizer
  第5回富山・バーゼル医薬品研究開発シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04694
[Presentation] ErbB2/ErbB3ヘテロ二量体におけるERKを介した新規ErbB2リン酸化部位の探索2018
- Author(s)
  河崎優希, 池ヶ谷真吾, 馬場絢子, 地子愛佳理, 櫻井宏明
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H04694
[Presentation] 小胞関連タンパク質Rab11によるEphA2局在化を介した細胞遊走機構2018
- Author(s)
  山畑伊織，櫻井宏明
- Organizer
  第27回日本がん転移学会学術集会
- Data Source
  KAKENHI-PROJECT-16H04694
[Presentation] がん細胞の遊走における小胞輸送関連タンパク質Rab11によるEphA2局在化の役割2018
- Author(s)
  山畑伊織，山村朋弘，周越，櫻井宏明
- Organizer
  第17回次世代を担う若手ファーマ・バイオフォーラム2018
- Data Source
  KAKENHI-PROJECT-16H04694
[Presentation] Emerging roles of the EphA2 noncanonical pathway in cancer progression2018
- Author(s)
  櫻井宏明
- Organizer
  2018 Humanitas International Cancer Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04694
[Presentation] ストレス応答シグナルによるp38を介したRSK-EphA2経路の活性化2018
- Author(s)
  大木良太，山畑伊織，周越，櫻井宏明
- Organizer
  日本薬学会北陸支部第130回例会
- Data Source
  KAKENHI-PROJECT-16H04694
[Presentation] 大腸がんにおけるEps15およびclathrin heavy chainを介したKITの発現制御機構2017
- Author(s)
  齋藤正英，櫻井宏明．
- Organizer
  第21回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16H04694
[Presentation] チロシンキナーゼ非依存的なリン酸化によるErbB4のフィードバック阻害機構2017
- Author(s)
  山口麻子，渡部聡子，福司弥生，田中智大，河崎優希，櫻井宏明
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H04694
[Presentation] アファチニブ耐性肺がん細胞におけるFGFRシグナルによるEphA2活性化機構2017
- Author(s)
  渡邉啓，櫻井宏明
- Organizer
  第26回日本がん転移学会学術集会
- Data Source
  KAKENHI-PROJECT-16H04694
[Presentation] がん細胞におけるErbBファミリーの膜近傍領域スレオニンリン酸化による活性調節機構2017
- Author(s)
  河崎優希, 櫻井宏明
- Organizer
  フォーラム2017 衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-16H04694
[Presentation] p38活性化はEGFR Ser-1015リン酸化を介したエンドサイトーシスを誘導する2017
- Author(s)
  大賀英司，田中智大，小澤龍彦，村口篤，櫻井宏明
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16H04694
[Presentation] チロシン脱リン酸化酵素を介した受容体型チロシンキナーゼErbBファミリーフィードバックの制御2017
- Author(s)
  河崎優希, 櫻井宏明
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16H04694
[Presentation] EGFシグナルにおけるp38によるリガンド非結合型EGFRの非定型的輸送制御．2016
- Author(s)
  田中智大，周越，櫻井宏明
- Organizer
  第76回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H04694
[Presentation] リガンド刺激時にリガンドが結合しなかったEGFRはMAPKを介して細胞内から制御される．2016
- Author(s)
  田中智大，周越，櫻井宏明．
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16H04694
[Presentation] ERKを介したErbB2非定型的リン酸化によるフィードバック阻害機構．2016
- Author(s)
  櫻井宏明，河崎優希．
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Place of Presentation
  別府
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-16H04694
[Presentation] ErbB2/ErbB3ヘテロ二量体におけるERKを介したErbB2 Thr-677リン酸化によるフィードバック制御.2016
- Author(s)
  河崎優希, 﨑村綾香, 朴哲珉, 周越, 都丸里佳, 成田香織, 小澤龍彦, 村口篤, 櫻井宏明.
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16H04694
[Presentation] EphA2チロシンキナーゼ型受容体の非定型的活性化による細胞運動能の制御．2016
- Author(s)
  櫻井宏明，横山悟，早川芳弘，矢野聖二，小泉桂一，済木育夫．
- Organizer
  第25回がん転移学会学術集会
- Place of Presentation
  米子
- Year and Date
  2016-06-21
- Data Source
  KAKENHI-PROJECT-16H04694
[Presentation] チロシンキナーゼ非依存的なErbB4リン酸化の役割．2016
- Author(s)
  渡部聡子，山口麻子，福司弥生，田中智大，河崎優希，櫻井宏明．
- Organizer
  第76回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H04694
[Presentation] Crucial roles of RSK in cell motility by catalyzing Ser-897 phosphorylation of EphA2.2016
- Author(s)
  Zhou Y, Yamada N, Tanaka T, Hori T, Yokoyama S, Hayakawa Y, Yano S, Fukuoka J, Koizumi K, Saiki I, Sakurai H．
- Organizer
  The 16th Biennial Congress of the Metastasis Research Society
- Place of Presentation
  China
- Year and Date
  2016-09-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04694
[Presentation] リガンド非依存的なKITのリン酸化制御機構．2016
- Author(s)
  木村美乃里，齊藤正英，櫻井宏明．
- Organizer
  第76回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H04694
[Presentation] TNF-αによるEps15のリン酸化制御2013
- Author(s)
  周越、田中智大、河崎優希、佐久間勉、櫻井宏明
- Organizer
  第12回次世代を担う若手ファーマ・バイオフォーラム2013
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590071
[Presentation] 炎症シグナルによるチロシンキナーゼ型受容体の活性調節機構2013
- Author(s)
  櫻井宏明
- Organizer
  大阪大学蛋白質研究所セミナー「シグナル伝達と解析技術のあらたな潮流」
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-23590071
[Presentation] Molecular mechanism of phosphorylation of EphA2 induced by inflammatory signal.2013
- Author(s)
  Zhou Y, Tanaka T, Kawasaki Y, Sakuma T and Sakurai H
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590071
[Presentation] 炎症シグナルを介したEphA2のリン酸化制御2013
- Author(s)
  山田直樹，周越，田中智大，河崎優希，佐久間勉，櫻井宏明
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590071
[Presentation] セリン/スレオニン残基のリン酸によるEGF受容体の活性化制御2013
- Author(s)
  田中智大、櫻井宏明
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23590071
[Presentation] リガンドによるEGFR 活性化制御におけるセリン/スレオニンリン酸化の役割2013
- Author(s)
  田中智大、周越、河崎優希、佐久間勉、櫻井宏明
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590071
[Presentation] IRF8 を介したTNF-α誘導性のアポトーシスによるCXCL16 高発現大腸がんの肝転移抑制2012
- Author(s)
  奇知芸, 伊東彩, 櫻井宏明, 入村達郎, 済木育夫, 小泉桂一
- Organizer
  第21回がん転移学会総会・学術集会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-22501042
[Presentation] リガンド濃度に依存したEGF受容体の多次元的リン酸化制御2012
- Author(s)
  田中智大, 周越, 申明淑, 河崎優希, 佐久間勉, 済木育夫, 櫻井宏明
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590071
[Presentation] ケモカインCXCL16 による大腸がんの肝臓および肺への相反する制御2012
- Author(s)
  奇知芸, 櫻井宏明, 入村達郎, 小泉桂一, 済木育夫
- Organizer
  第16回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22501042
[Presentation] 活性変異型EGFRを発現するヒト非小細胞肺がん細胞におけるEGFR セリン・スレオニン残基のリン酸化機構2012
- Author(s)
  河西美保, 小泉桂一, 済木育夫, 櫻井宏明
- Organizer
  第16回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22501042
[Presentation] TAK1を標的としたがん治療法の確立に向けて2012
- Author(s)
  櫻井宏明
- Organizer
  第16回日本がん分子標的治療学会学術集会
- Place of Presentation
  広島
- Year and Date
  2012-07-12
- Invited
- Data Source
  KAKENHI-PUBLICLY-23117516
[Presentation] モカインCXCL16による大腸がんの肝臓および肺への相反する制御2011
- Author(s)
  奇知芸, 櫻井宏明, 入村達郎, 小泉桂一, 済木育夫
- Organizer
  第15回日本がん分子標的治療学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22501042
[Presentation] EGF受容体のスレオニンリン酸化によるチロシンキナーゼ活性の抑制機構2011
- Author(s)
  佐藤佳奈絵, 申明淑, 河西美保, 済木育夫, 櫻井宏明
- Organizer
  日本生化学会北陸支部第29回大会
- Place of Presentation
  金沢大学
- Year and Date
  2011-05-28
- Data Source
  KAKENHI-PUBLICLY-23117516
[Presentation] TAK1-mediated serine/threonine phosphorylation of EGFR via p38/ERK : NF-κB-independent survival pathways in TNF-α signaling2011
- Author(s)
  Shin M.S., Nishimura M., Singhirunnusorn P., Suzuki S., Kawanishi M, Koizumi K, Saiki I., Sakurai H.
- Organizer
  13th International TNF Conference
- Place of Presentation
  淡路夢舞台国際会議場
- Data Source
  KAKENHI-PUBLICLY-23117516
[Presentation] 活性変異型EGFRを発現するヒト非小細胞肺がん細胞におけるEGFRセリン・スレオニン残基のリン酸化機構2011
- Author(s)
  河西美保, 小泉桂一, 済木育夫, 櫻井宏明
- Organizer
  第15回日本がん分子標的治療学会学術集会
- Place of Presentation
  ホテル日航東京
- Data Source
  KAKENHI-PROJECT-23590071
[Presentation] 活性変異型EGFRを発現するヒト非小細胞肺がん細胞におけるEGFRセリン・スレオニン残基のリン酸化機構2011
- Author(s)
  河西美保, 申明淑, 佐藤佳奈絵, 小泉桂一, 済木育夫, 櫻井宏明
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PUBLICLY-23117516
[Presentation] 活性変異型EGFRを発現するヒト非小細胞肺がん細胞におけるEGFRセリン・スレオニン残基のリン酸化機構2011
- Author(s)
  河西美保, 申明淑, 佐藤佳奈絵, 小泉桂一, 済木育夫, 櫻井宏明
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-23590071
[Presentation] Chemokine CXCL16 oppositely modulates liver and lung metastasis of colon cancer cells2011
- Author(s)
  奇知芸, 伊東彩, 櫻井宏明, 入村達郎, 済木育夫, 小泉桂一
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22501042
[Presentation] TAK1-mediated serine/threonine phosphorylation of EGFR via p38/ERK: NF-κB-independent survival pathways in TNF-α signaling.2011
- Author(s)
  Shin M.S., Nishimura M., Singhirunnusorn P., Suzuki S., Kawanishi M, Koizumi K., Saiki I., and Sakurai H.
- Organizer
  13th International TNF Conference
- Place of Presentation
  淡路夢舞台国際会議場
- Data Source
  KAKENHI-PROJECT-23590071
[Presentation] 活性変異型EGFRを発現するヒト非小細胞肺がん細胞におけるEGFR セリン・スレオニン残基のリン酸化機構2011
- Author(s)
  河西美保, 小泉桂一, 済木育夫, 櫻井宏明
- Organizer
  第15回日本がん分子標的治療学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22501042
[Presentation] ERK-mediated Thr-669 phosphorylation of EGFR down-regulates its constitutive tyrosine phosphorylation in human breast cancer cells.2011
- Author(s)
  Shin M-S., Sato K., Sakimura A., Koizumi K., Saiki I., and Sakurai H.
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23590071
[Presentation] 大腸がん細胞に発現するケモカインCXCL16 は臓器特異的な免疫系を介して肝および肺への転移挙動を相反させる2011
- Author(s)
  伊東彩、櫻井宏明、入村達郎、済木育夫、小泉桂一
- Organizer
  第20回日本がん転移学会学術集会・総会
- Place of Presentation
  浜松
- Year and Date
  2011-07-01
- Data Source
  KAKENHI-PROJECT-22501042
[Presentation] 炎症カスケードと治療標的分子2011
- Author(s)
  櫻井宏明
- Organizer
  フォーラム富山「創薬」第33回研究会
- Place of Presentation
  富山国際会議場(招待講演)
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PUBLICLY-23117516
[Presentation] リンパ管新生に対するeNOSおよびHsp90の影響2010
- Author(s)
  小泉桂一,仙田一貴,櫻井宏明,済木育夫
- Organizer
  第19回日本がん転移学会学術集会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-22501042
[Presentation] Kampo-Kinome解析:十全大補湯構成生薬のプロテインキナーゼ阻害活性2010
- Author(s)
  櫻井宏明
- Organizer
  第27回和漢医薬学会学術大会
- Place of Presentation
  京都薬科大学
- Year and Date
  2010-08-28
- Data Source
  KAKENHI-PROJECT-21659025
[Presentation] The role of eNOS-Hsp90 interaction and Calpain 1 involvement in lymphangiogenesis in vitro2010
- Author(s)
  Prangsaengtong O., Koizumi K., Sakurai H., and Saiki I
- Organizer
  The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  Kyoto.
- Data Source
  KAKENHI-PROJECT-22501042
[Presentation] 和漢薬ライブラリーの構築とその応用2010
- Author(s)
  櫻井宏明
- Organizer
  富山大学生命融合科学教育部シンポジウム「富山発医療・創薬イノベーションに向けて」
- Place of Presentation
  高志会館(富山市)
- Year and Date
  2010-03-08
- Data Source
  KAKENHI-PROJECT-21659025
[Presentation] 和漢薬データベースによる天然薬物研究の活性化2010
- Author(s)
  櫻井宏明
- Organizer
  第13回天然薬物研究方法論アカデミーシンポジウム
- Place of Presentation
  名古屋市ルブラ王山
- Year and Date
  2010-08-20
- Data Source
  KAKENHI-PROJECT-21659025
[Presentation] TNF-αによるEGFRのSer/Thrリン酸化に対する抗EGFR薬の効果2010
- Author(s)
  櫻井宏明,小泉桂一,済木育夫
- Organizer
  第19回日本がん転移学会学術集会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-22501042
[Presentation] 非小細胞肺がん細胞におけるEGFRのSer/Thrリン酸化の解析2010
- Author(s)
  櫻井宏明,小泉桂一,済木育夫
- Organizer
  第14回がん分子標的治療研究会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22501042
[Presentation] 肺がん細胞におけるEGFRのSer/Thrリン酸化の制御機構の解析2010
- Author(s)
  河西美保,申明淑,西村美紀,小泉桂一,済木育夫,櫻井宏明
- Organizer
  第28回日本生化学会北陸支部大会
- Place of Presentation
  福井
- Year and Date
  2010-05-29
- Data Source
  KAKENHI-PROJECT-22501042
[Presentation] Kampo-Kinome解析に基づく和漢薬の生物活性情報2009
- Author(s)
  櫻井宏明
- Organizer
  第30回富山大学和漢医薬学総合研究所特別セミナー「和漢薬とバイオインフォマティクス」
- Place of Presentation
  富山県民会館
- Year and Date
  2009-10-09
- Data Source
  KAKENHI-PROJECT-21659025
[Presentation] Periostin associates with TAB1 to activate TAK1 and suppresses cell invasiveness2008
- Author(s)
  Isono T., Kim C-J., Sakurai H., Okada Y., Inoue H.
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19590063
[Presentation] HTLV-1 Taxによる恒常的TAK1活性化と細胞内シグナル伝達における役割2008
- Author(s)
  櫻井宏明, 小泉桂一, 済木育夫
- Organizer
  第12回がん分子標的治療研究会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590063
[Presentation] Physiologieal functions of constiultive TAK1 activation in Tax-positive HTLV-I-infected cells2008
- Author(s)
  櫻井宏明
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-19590063
[Presentation] Cross interference with TNF-α-Induced TAK1 activation via EGFR-mediated p38 phosphorylation of TAK1-binding protein 12008
- Author(s)
  Nishimura M., Shin M-S., Singhirunnu- sorn P., Sugishima Y., Suzuki S., Koizumi K., Saiki I., Sakurai H.
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19590063
[Presentation] Physiological functions of constitutive TAK1 activation in Tax-positive HTLV-I-infected cells. JCA-AACR Joint Symposium "NF-κB is a Novel Molecular Target of Cancer/Leukemia"2008
- Author(s)
  Sakurai H.
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19590063
[Presentation] p38αを介するEGFシグナルとTNF-αシグナルの交差干渉とその分子機構2008
- Author(s)
  申明淑, Pattama Singhirunnusorn, 杉嶋祐巳子, 西村美紀, 鈴木俊輔, 小泉桂一, 済木育夫, 櫻井宏明
- Organizer
  第26回日本生化学会北陸支部会
- Place of Presentation
  金沢
- Year and Date
  2008-05-30
- Data Source
  KAKENHI-PROJECT-19590063
[Presentation] Tax陽性HTLV-1感染細胞における恒常的TAK1活性化の生理機能解析2008
- Author(s)
  鈴木俊輔, 周越, 高崎一朗, Pattama Singhirunnusorn, 田渕圭章, 山岡昇司, 小泉桂一, 済木育夫, 櫻井宏明
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会・合同大会(BMB2008)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19590063
[Presentation] TAK1ストレス応答シグナルによるがん悪性化の分子機構2008
- Author(s)
  櫻井宏明
- Organizer
  第11回癌と骨病変研究会
- Place of Presentation
  東京
- Year and Date
  2008-11-28
- Data Source
  KAKENHI-PROJECT-19590063
[Presentation] Site-specific Lys-63-linked polyubiquitination of TAK1 plays a critical role in inducing the TRAF6-MEKK3-TAK1 complex formation to activate TAK12008
- Author(s)
  Yamazaki K., Gohda J., Kanayama A., Sakurai H., Inoue J.
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19590063
[Presentation] TAK1シグナルによるがん悪性化の分子機構, 支部奨励賞受賞講演2007
- Author(s)
  櫻井宏明
- Organizer
  第25回日本生化学会北陸支部会
- Place of Presentation
  金沢
- Year and Date
  2007-05-26
- Data Source
  KAKENHI-PROJECT-19590063
[Presentation] Role of TAK1 in cytokine signaling and cancer progression2007
- Author(s)
  Sakurai H.
- Organizer
  International Symposium on NanoBio- Sciences
- Place of Presentation
  Seoul
- Year and Date
  2007-08-20
- Data Source
  KAKENHI-PROJECT-19590063
[Presentation] p38α を介するEGFシグナルとTNF-αシグナルの交差干渉とその分子機構2007
- Author(s)
  申明淑, Singhirunnusorn Pattama, 杉島祐巳子, 鈴木俊輔, 済木育夫, 櫻井宏明
- Organizer
  第30回日本分子生物学年会・第80回日本生化学会大会・合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590063
[Presentation] Epoxyquinol B inhibits activation of transcription factor NF-κB signaling through the inhibition of TAK1 activity2007
- Author(s)
  Kamiyama H., Kakeya H., Usui T., Sakurai H., Shoji M., Hayashi Y. and Osada H.
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590063
[Presentation] Periostin activates TAK1 and suppresses cell invasiveness2007
- Author(s)
  Isono T., Kim C-J., Sakurai H., Okada Y. and Inoue H.
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590063
[Presentation] Heregulin-induced activation of ErbB3 and EGFR promotes tumor growth and metastasis in B16-BL6 melanoma cells2007
- Author(s)
  Ueno Y., Sakurai H., Tsunoda S., Choo M-K., Matsuo M., Koizumi K. and Saiki I.
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590063
[Presentation] HTLV-1 Taxによる恒常的TAK1活性化とその細胞内シグナル機構における役割2007
- Author(s)
  鈴木俊輔, Pattama Singhirunnusorn, 森昭憲, 山岡昇司, 北島勲, 済木育夫, 櫻井宏明
- Organizer
  第30回日本分子生物学年会・第80回日本生化学会大会・合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590063
[Presentation] TNF-αによるリガンド依存性EGFR活性化の抑制とその分子機序2007
- Author(s)
  櫻井宏明, 済木育夫
- Organizer
  第11回がん分子標的治療研究会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19590063
[Presentation] Constitutive activation of TAK1 by HTLV-1 Tax-dependent overexpression of TAB2 induces activation of JNK-ATF22007
- Author(s)
  Suzuki S., Singhirunnusorn P., Mori A., Yamaoka S., Kitajima I., Saiki I. and Sakurai H.
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590063
[Presentation] HUVECの管腔形成におけるTAK1ストレス応答シグナルの役割2007
- Author(s)
  Min-Kyung Choo, 櫻井宏明, 小泉桂一, 済木育夫
- Organizer
  第16回がん転移学会学術総会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-19590063
[Presentation] B16-BL6メラノーマ細胞におけるEGFR/ErbB3活性化を介した転移能の亢進2007
- Author(s)
  上野陽子, 櫻井宏明, Min-Kyung Choo, 小泉桂一, 済木育夫
- Organizer
  第16回がん転移学会学術総会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-19590063
[Presentation] Transient suppression of ligand- mediated activation of EGFR by TNF-α through the TAK1-p38 signaling pathway2007
- Author(s)
  Singhirunnusorn P., Ueno Y., Matsuo M., Suzuki S., Saiki I. and Sakurai H.
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590063
[Presentation] RSK-EphA2シグナルを介したがん細胞運動の制御機構
- Author(s)
  周越，山田直樹，田中智大，櫻井宏明
- Organizer
  第23回日本がん転移学会学術集会
- Place of Presentation
  金沢
- Year and Date
  2014-07-14 – 2014-07-15
- Data Source
  KAKENHI-PROJECT-23590071
[Presentation] 炎症シグナルにおけるEphA受容体のリン酸化制御
- Author(s)
  山田直樹，周越，河崎優希，櫻井宏明
- Organizer
  第13回次世代を担う若手ファーマ・バイオフォーラム2014
- Place of Presentation
  富山
- Year and Date
  2014-09-20 – 2014-09-21
- Data Source
  KAKENHI-PROJECT-23590071
[Presentation] RSK-EphA2シグナルを介したがん細胞運動の制御機構
- Author(s)
  周越，山田直樹，田中智大，櫻井宏明
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-23590071

1. SAIKI Ikuo (80133776)

# of Collaborated Projects: 5 results

# of Collaborated Products: 48 results
2. KOIZUMI Keiichi (10334715)

# of Collaborated Projects: 3 results

# of Collaborated Products: 19 results
3. 横山悟 (90613498)

# of Collaborated Projects: 2 results

# of Collaborated Products: 41 results
4. FUKUOKA Junya (00324575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KONDO Takashi (40143937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. ZHAO Qing-Li (90313593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MATSUMOTO Kinzo (10114654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TOHDA Michihisa (20207525)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MURAKAME Yukihisa (00377269)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YANAKA Noriyuki (70346526)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KATO Norihisa (20144892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Yuki Kawasaki (30432107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
13. 義江修 (10166910)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 稗島州男 (10322570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 中山隆志 (60319663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 田中謙 (60418689)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 小澤龍彦 (10432105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
18. 周越 (10733339)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. 林龍二 (60345585)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. ISHIHAMA YASUSHI

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. SUGIYAMA Naoyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. MIZUMOTO Yasunari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 田渕圭章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 早川芳弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 佐久間勉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 岸裕幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 森紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakurai Hiroaki 櫻井 宏明

SAKURAI Hiroaki 櫻井 宏明

Research Projects

Research Products

Co-Researchers

Cancer pathophysiology and treatment from the perspective of dual-mode control of EGFRPrincipal Investigator

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Alternative activation mechanisms of receptor tyrosine kinases in inflammation-induced cancer progressionPrincipal Investigator

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Noncanonical activation of receptor tyrosine kinases: next target mechanisms for cancer progressionPrincipal Investigator

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Functional interactions between inflammatory signal and growth singaling in the Warburg effect in cancer cellsPrincipal Investigator

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Effects of a TAK1 inhibitor on radiation-and heat-induced cell killing

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炎症シグナルによるＥｒｂＢチロシンキナーゼのＳｅｒ／Ｔｈｒリン酸化とがん悪性化Principal Investigator

Principal Investigator

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Role of TNF-TAK1 signaling pathway in tumor microenvironments of metastasisPrincipal Investigator

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Development of DDS which accumulate cancer cell by chemokines function in peritoneal carcinomatosis therapy

Principal Investigator

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Kampo-Kinome解析によるケミカルバイオロジーの展開Principal Investigator

Principal Investigator

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ROLE OF TAK1 IN CROSS INTERFERENCE BETWEEN TNF-α AND EGF SIGNALING PATHWAYSPrincipal Investigator

Principal Investigator

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Isolation and characterization of mammalian glycerophosphodiester phosphodiesterases

Principal Investigator

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Search, identification, and functional analysis of target molecules for cerebrovascular dementia treatment using bioactivities of Kampo medicines

Principal Investigator

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Molecular mechanism of metastasis promoting activity of stress response kinase TAK1Principal Investigator

Principal Investigator

Project Period (FY)

Sakurai Hiroaki 櫻井宏明

SAKURAI Hiroaki 櫻井宏明