NARUISHI Koji 成石浩司

Researcher Number	00346446
Affiliation *help	2016 – 2018 : 徳島大学, 病院, 講師 2015 : 徳島大学, 大学病院, 講師 2010 – 2012 : 岩手医科大学, 歯学部, 准教授 2012 : 岩手医科大学, 歯学部, 歯学部 2010 : 岡山大学, 岡山大学病院, 講師 … More
Review Section/Research Field	Principal Investigator Periodontal dentistry / Periodontology Except Principal Investigator Periodontology / Conservative dentistry / Periodontal dentistry / Respiratory organ internal medicine / Periodontal dentistry
Keywords	Principal Investigator 歯肉線維芽細胞 / 歯周病悪化メカニズム / 糖尿病 / マクロファージ / MMP-3 / インターロイキン6 / カルプロテクチン / IL-6 / 糖尿病関連歯周炎 / 糖尿病性歯周炎 … More Except Principal Investigator 歯周病 / 遺伝子導入 / 慢性感染 / MAPK / 口腔管理 / TNF-αパスウェイ / バイオマーカー / 歯根膜 / 白血球数 / インターロイキン1a / IL-1 / oral infection control / オーラルケア / マルチセンター式研究 / 慢性閉塞性肺疾患 / 口腔感染症 / 歯周疾患 / 歯周病原細菌に対する血漿IgG抗体価 / 遺伝子発現 / 転写因子結合部位 / RhoA / 糖尿病関連歯周炎 / 糖尿病 / がん転移 / rat wounded pulp / Rho-kinase / 易感染性宿主 / プロモーター活性 / 骨芽細胞 / ストレスファイバー / Y-27632 / バイオフィルム / 歯周病菌に対するIgG抗体価 / 感染症 / 細菌検査 / 根尖病巣 / 宿主免疫 / PBSCT / Rho / ROCK / TNF-α signaling / COPD増悪 / 指尖採血 / 人工細胞 / インフラマソーム / 無細胞蛋白合成 / ラミニン / 保存修復学 / リポソーム / RhoA-ROCKシグナル / TNF-αシグナル / dentin-pulp complex / 感染 / bacterial detection / 慢性歯周炎 / periodontal desease / 細胞分化 / 根尖性歯周炎 / インターロイキン1α / leukocyte / 最終糖化産物 / cell death / transcription factor-binding site / 診断デバイス / 歯周炎 / 象牙質・歯髄複合体 / 歯周病診断 / over-expression / ラット創傷歯髄 / 気道炎症 / compromised host / 癌転移 / 病巣治癒 / 細胞死 / インプラント粘膜炎・周囲炎 / 末梢血幹細胞移植 / 冶癒 / 口腔ケア / 細胞増殖活性 / promoter activity / 疾患診断 / インプラント周囲溝液 / 慢性炎症 / 細胞接着活性 Less

人工細胞を用いたオーラルケアシステムの基礎研究Ongoing
- Principal Investigator
  
  木戸淳一
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Periodontology
- Research Institution
  The University of Tokushima
糖尿病関連歯周炎のIL-6動態に着目したマクロファージ・線維芽細胞クロストークPrincipal InvestigatorOngoing
- Principal Investigator
  
  成石浩司
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontology
- Research Institution
  The University of Tokushima
最終糖化産物とインフラマソームの関連から探る糖尿病関連歯周炎の病態Ongoing
- Principal Investigator
  
  板東美香
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontology
- Research Institution
  The University of Tokushima
細胞性バイオマーカーを用いたインプラント疾患の診断とデバイス開発Ongoing
- Principal Investigator
  
  木戸淳一
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Periodontology
- Research Institution
  The University of Tokushima
最終糖化産物AGEsによる糖尿病関連歯周炎の重症化機序の解明と診断システムの構築Ongoing
- Principal Investigator
  
  永田俊彦
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Periodontology
- Research Institution
  The University of Tokushima
ＡＰ－１によるカテプシン産生制御に着目した歯肉増殖症・歯周病診断の新機軸Principal Investigator
- Principal Investigator
  
  成石浩司
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Periodontal dentistry
- Research Institution
  Iwate Medical University
How periodontitis can affect prostate cancer metastasis?
- Principal Investigator
  
  TANIMOTO Ichiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Okayama University
Chronic infection and immune response in COPD patients
- Principal Investigator
  
  MURO Shigeo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kyoto University
Healing mechanism of rat experimental periapical lesions targeting laminin γ2 expression
- Principal Investigator
  
  HATANAKA Kazu
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Okayama University
Possible Mechanisms of Progression of Periodontits by MMP-3 in Diabetic PatientsPrincipal Investigator
- Principal Investigator
  
  NARUISHI Koji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Okayama University
Investigation of the mechanisms of osteogenic differentiation by RhoA in periodontal ligament cells for cell transplantation
- Principal Investigator
  
  YAMAMOTO Tadashi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Okayama University
New bactericide delivery system for oral care
- Principal Investigator
  
  TANIMOTO Ichiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Okayama University
Mail Medicine using Fingertip Plasma for Screening and Monitoring Periodontitis
- Principal Investigator
  
  TAKASHIBA Shogo
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Okayama University
糖尿病患者の歯周病悪化を誘発する新規因子の網羅的な解析および同定Principal Investigator
- Principal Investigator
  
  成石浩司
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Okayama University
The effect on dentin-pulp complex by FIP-2 isolated from rat wounded pulp
- Principal Investigator
  
  ARAI Hideo
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Okayama University
Study for oral infectious control during peripheral blood stem cell transplantation
- Principal Investigator
  
  TANIMOTO Ichiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Okayama University

All 2017 2016 2015 2013 2011 2007 2006

All Journal Article Presentation

[Journal Article] Clinical Significance of GCF sIL-6R and Calprotectin to Evaluate the Periodontal Inflammation2017
- Author(s)
  Kajiura Y, Lew JH, Ikuta T, Nishikawa Y, Kido JI, Nagata T, Naruishi K
- Journal Title
  
  Ann Clin Biochem
  
  Volume : 印刷中
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11832
[Journal Article] Calprotectin Induces IL-6 and MCP-1 Production via Toll-Like Receptor 4 Signaling in Human Gingival Fibroblasts.2017
- Author(s)
  2.Nishikawa Y, Kajiura Y, Lew JH, Kido JI, Nagata T, Naruishi K.
- Journal Title
  
  J Cell Physiol
  
  Volume : 232 Pages : 1862-1871
- Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05054
[Journal Article] Calprotectin induces IL-6 and MCP-1 production via Toll-like receptor 4 signaling in human gingival fibroblasts2017
- Author(s)
  Nishikawa Y, Kajiura Y, Lew JH, Kido J, Nagata T, Naruishi K.
- Journal Title
  
  J Cell Physiol
  
  Volume : 印刷中 Pages : 1862-1871
- DOI
  10.1002/jcp.25724
- Peer Reviewed / Int'l Joint Research / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25253104, KAKENHI-PROJECT-15K15701, KAKENHI-PROJECT-16K11832
[Journal Article] Association between periodontal condition and kidney dysfunction in japanese aduls: A cross-sectional study2016
- Author(s)
  1.Naruishi K, Oishi K, Inagaki Y, Horibe M, Bando M, Ninomiya M, Kawahara K, Minakuchi J, Kawashima S, Shima K, Kido J, Nagata T.
- Journal Title
  
  Clinical and Experimental Dental Research
  
  Volume : 2 Pages : 1-8
- DOI
  10.1002/cre2.39
- Peer Reviewed / Int'l Joint Research / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H05054, KAKENHI-PROJECT-26463135
[Journal Article] 肥満糖尿病ラット歯周炎の歯肉組織におけるオステオポンチンの局在2015
- Author(s)
  稲垣裕司、中島由紀子、堀部ますみ、生田貴久、梶浦由加里、成石浩司、木戸淳一、永田俊彦
- Journal Title
  
  日本歯周病学会会誌
  
  Volume : 57 Pages : 149-158
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05054
[Journal Article] YKL-40 level in gingival crevicular fluid from patients with periodontitis and type 2 diabetes2015
- Author(s)
  Kido J, Bando Y, Bando M, Kajiura Y, Hiroshima Y, Inagaki Y, Murata H, Ikuta T, Kido R, Naruishi K, Funaki M, Nagata T.
- Journal Title
  
  Oral Diseases
  
  Volume : 21 Pages : 667-673
- DOI
  10.1111/odi.12334
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253104, KAKENHI-PROJECT-15H05054
[Journal Article] Secreted caveolin-1 enhances periodontal inflammation by targeting gingival fibroblasts2013
- Author(s)
  Takizawa N, Sawada S, Chosa N, Ishisaki A, Naruishi K
- Journal Title
  
  Biomed Res
  
  Volume : 34(1) Pages : 1-11
- Data Source
  KAKENHI-PROJECT-22592312
[Journal Article] Naruishi K, Omori K, Maeda H, Sonoi N, Funakoshi K, Hirai K, Ishii M, Kubo K, Kobayashi H, Tomiyama T, Yamamoto D, Tanimoto I,Kunimatsu K, and Takashiba S2011
- Author(s)
  Naruishi K, Omori K, Maeda H, Sonoi N, Funakoshi K, Hirai K, Ishii M, Kubo K, Kobayashi H, Tomiyama T, Yamamoto D, Tanimoto I,Kunimatsu K, and Takashiba S
- Journal Title
  
  J Biol Regul Homeost Agents
  
  Volume : 25(2) Pages : 195-202
- Data Source
  KAKENHI-PROJECT-22592312
[Journal Article] Immune responses to porphyromonas gingivalis infection suppress systemic inflammatory response in experimental murine model2011
- Author(s)
  Naruishi, Koji
- Journal Title
  
  Journal of biological regulators and homeostatic agents
  
  Volume : 25 Pages : 195-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592312
[Journal Article] cAMP-response element binding protein(CREB) regulates cyclosporine-A-mediated down-regulation of cathepsin B and L synthesis2007
- Author(s)
  Omori, K, et. al.
- Journal Title
  
  Cell Tissue Research 330
  
  Pages : 75-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791592
[Journal Article] 高血糖状態で培養したヒト歯肉線維芽細胞の網羅的な遺伝子解析2006
- Author(s)
  成石浩司ら
- Journal Title
  
  第20回日本顎頭蓋機能学会記念学術大会抄録集 20巻・1号
  
  Pages : 19-19
- Data Source
  KAKENHI-PROJECT-18791592
[Presentation] AGE and Porphyromonas gingivalis-LPS Increase Sclerostin Expression in Osteocytes2017
- Author(s)
  2.Sakamoto E, Takagi R, Inagaki Y, Naruishi K, Kido J, Nagata T
- Organizer
  95th International Association for Dental Research, General Session & Exhibition
- Place of Presentation
  San Francisco, USA
- Year and Date
  2017-03-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05054
[Presentation] Advanced Glycation End-Products Increase Calprotectin in Human Gingival Epithelial Cells2017
- Author(s)
  1.Hiroshima Y, Sakamoto E, Abe K, Yoshida K, Naruishi K, Nagata T, Shinohara Y, Geczy CL, Kido J
- Organizer
  95th International Association for Dental Research, General Session & Exhibition
- Place of Presentation
  San Francisco, USA
- Year and Date
  2017-03-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05054
[Presentation] カルプロテクチンはヒト歯肉線維芽細胞のTLR4を介して炎症性関連因子の発現を亢進する2016
- Author(s)
  西川泰史，成石浩司，梶浦由加里，Lew Jung Hwan，木戸淳一，永田俊彦
- Organizer
  第144回日本歯科保存学会春期学術大会
- Place of Presentation
  栃木県総合文化センター「栃木県宇都宮市」
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-16K11832
[Presentation] Periodontal evaluation using sIL-6R/calprotectin in GCF during SPT phase2016
- Author(s)
  3.Lew JH, Naruishi K, Kajiura Y, Ikuta T, Nishikawa Y, Kido J, Nagata T
- Organizer
  The 102nd Annual Meeting of the American Academy of Periodontology
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-09-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05054
[Presentation] High Glucose Enhances P. gingivalis-induced Cytokine Production in THP-1 Monocytes2016
- Author(s)
  4.Kajiura Y, Naruishi K, Nakajima Y, Nishikawa Y, Lew JH, Kido J, Nagata T
- Organizer
  94th International Association for Dental Research, General Session & Exhibition
- Place of Presentation
  Seoul, Korea
- Year and Date
  2016-06-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05054
[Presentation] High Glucose Enhances IL-6-induced Protease Productions in Gingival Fibroblasts2016
- Author(s)
  5.Lew JH, Naruishi K, Kajiura Y, Nishikawa Y, Kido J, Nagata T
- Organizer
  94th International Association for Dental Research, General Session & Exhibition
- Place of Presentation
  Seoul, Korea
- Year and Date
  2016-06-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05054
[Presentation] High glucose enhances P. gingivalis-induced ctokine production in THP-1 monocytes2016
- Author(s)
  Kajiura Y, Naruishi K, Nakajima Y, Nishikawa Y, Lwe JH, Kido J, Nagata T
- Organizer
  94th General Session of the IADR
- Place of Presentation
  Seoul (Korea)
- Year and Date
  2016-06-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05054
[Presentation] カロテノイドは高グルコース下で培養したヒト歯肉線維芽細胞のIL-6誘導性蛋白分解酵素産生を抑制する2016
- Author(s)
  Lew Jung-Hwan，成石浩司，梶浦由加里，西川泰史，木戸淳一，永田俊彦
- Organizer
  第59回春季日本歯周病学会
- Place of Presentation
  かごしま県民交流センター（鹿児島県鹿児島市）
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-15H05054
[Presentation] カルプロテクチンはヒト歯肉線維芽細胞のTLR4を介して炎症性関連因子の発現を亢進する2016
- Author(s)
  9.西川泰史，成石浩司，梶浦由加里，Lew Jung Hwan，木戸淳一，永田俊彦
- Organizer
  第144回日本歯科保存学会春期学術大会
- Place of Presentation
  栃木県総合文化センター、栃木県宇都宮市
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-15H05054
[Presentation] 最終糖化産物はヒト歯肉線維芽細胞におけるIL-6およびICAM1の発現を増加する2016
- Author(s)
  8.板東美香，梶浦由加里，野中康平，坂本英次郎，成石浩司，木戸淳一，永田俊彦
- Organizer
  第60回日本歯周病学会秋期学術大会
- Place of Presentation
  朱鷺メッセ、新潟県新潟市
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-15H05054
[Presentation] マウス骨細胞株MLO-Y4-A2のスクレロスチン発現における最終糖化産物およびLPSの影響2016
- Author(s)
  7.坂本英次郎，稲垣裕司，木戸淳一，高木亮輔，生田貴久，成石浩司，永田俊彦
- Organizer
  第145回日本歯科保存学会春期学術大会
- Place of Presentation
  キッセイ文化ホール、長野県松本市
- Year and Date
  2016-10-27
- Data Source
  KAKENHI-PROJECT-15H05054
[Presentation] Calprotectin Induces the Expression of Inflammation-related Molecules in Gingival Fibroblasts2016
- Author(s)
  6.Nishikawa Y, Naruishi K, Kajiura Y, Lew JH, Kido J, Nagata T
- Organizer
  94th International Association for Dental Research, General Session & Exhibition
- Place of Presentation
  Seoul, Korea
- Year and Date
  2016-06-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05054
[Presentation] カロテノイドは高グルコース下で培養したヒト歯肉線維芽細胞のIL-6誘導性蛋白分解酵素産生を抑制する2016
- Author(s)
  10.Lew Jung Hwan，成石浩司，梶浦由加里，西川泰史，木戸淳一，永田俊彦
- Organizer
  第59回日本歯周病学会春期学術大会
- Place of Presentation
  かごしま県民交流センター、鹿児島県鹿児島市
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-15H05054
[Presentation] 最終糖化産物は口腔上皮細胞の遺伝子発現を調節する2015
- Author(s)
  坂本英次郎、木戸淳一、梶浦由加里、板東美香、稲垣裕司、成石浩司、生田貴久、永田俊彦
- Organizer
  第58回秋季日本歯周病学会
- Place of Presentation
  アクトシティ浜松（静岡県浜松市）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15H05054

1. TAKASHIBA Shogo (50226768)

# of Collaborated Projects : 8results

# of Collaborated Products : 1results
2. TANIMOTO Ichiro (00280686)

# of Collaborated Projects : 4results

# of Collaborated Products : 1results
3. 木戸淳一 (10195315)

# of Collaborated Projects : 4results

# of Collaborated Products : 4results
4. NAGATA Toshihiko (10127847)

# of Collaborated Projects : 3results

# of Collaborated Products : 18results
5. SHIOMI Nobuyuki (90432632)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
6. MAEDA Hiroshi (00274001)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
7. MINESHIBA Junji (00509383)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
8. HATANAKA Kazu (50362992)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
9. YAMAMOTO Tadashi (50432662)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
10. OMORI Kazuhiro (20549860)

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# of Collaborated Products : 1results
11. ARAI Hideo (70222718)

# of Collaborated Projects : 2results

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12. 板東美香 (10510000)

# of Collaborated Projects : 2results

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13. 吉田賀弥 (60363157)

# of Collaborated Projects : 2results

# of Collaborated Products : 1results
14. ABIKO Nobumitu (70050086)

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15. YAMAZAKI Kazuhisa (00182478)

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16. NAGASAWA Tosiyuki (90262203)

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# of Collaborated Products : 0results
17. HINO Takamune (20274102)

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18. YOSHIMURA Atsutoshi (70253680)

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19. SHIMAUCHI Hidetoshi (70187425)

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20. OGATA Yorimasa (90204065)

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21. NUMABE Yukihiro (90198557)

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22. NOGUCHI Toshihide (50014262)

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23. MURAKAMI Shinya (70239490)

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24. SHIMOE Masayuki (60580264)

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25. YAMAGUCHI Tomoko (90580267)

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26. KAKO Aya (60448230)

# of Collaborated Projects : 1results

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27. YAMASHIRO Keisuke (30581087)

# of Collaborated Projects : 1results

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28. SONOYAMA Wataru (40325121)

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29. MURO Shigeo (60344454)

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30. ITO Isao (40447959)

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31. SATO Susumu (40378691)

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32. MISHIMA Michiaki (60190625)

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33. WATANABE Masami (70444677)

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34. MYOKAI Fumio (50263588)

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35. MINESHIBA Fumi (90346461)

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36. NISHIMURA Fusanori (80208222)

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37. 黄瀬大輔 (50572418)

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38. 星野勇馬 (00378746)

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39. 小川恵美子 (00378671)

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40. 武田泰典 (60137536)

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44. 篠原康雄 (60226157)

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45. 廣島佑香 (60545143)

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46. 稲垣裕司 (50380019)

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47. 梶浦由加里 (40758869)

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48. 二宮雅美

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NARUISHI Koji 成石 浩司

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人工細胞を用いたオーラルケアシステムの基礎研究Ongoing

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糖尿病関連歯周炎のIL-6動態に着目したマクロファージ・線維芽細胞クロストークPrincipal InvestigatorOngoing

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最終糖化産物とインフラマソームの関連から探る糖尿病関連歯周炎の病態Ongoing

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細胞性バイオマーカーを用いたインプラント疾患の診断とデバイス開発Ongoing

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最終糖化産物AGEsによる糖尿病関連歯周炎の重症化機序の解明と診断システムの構築Ongoing

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ＡＰ－１によるカテプシン産生制御に着目した歯肉増殖症・歯周病診断の新機軸Principal Investigator

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Possible Mechanisms of Progression of Periodontits by MMP-3 in Diabetic PatientsPrincipal Investigator

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糖尿病患者の歯周病悪化を誘発する新規因子の網羅的な解析および同定Principal Investigator

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NARUISHI Koji 成石浩司