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YAMAMOTO Tadashi  山本 直史

Researcher Number 50432662
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-7180-1567
External Links
Affiliation (Current) 2022: 岡山大学, 大学病院, 教授
Affiliation (based on the past Project Information) *help 2021 – 2022: 岡山大学, 医歯薬学域, 准教授
2018 – 2020: 岡山大学, 医歯薬学総合研究科, 准教授
2011 – 2018: 岡山大学, 大学病院, 講師
2010 – 2011: 岡山大学, 病院, 講師
2010: Okayama University, 岡山大学病院, 講師 … More
2009: Okayama University, 大学病院, 講師
2008: Okayama University, 医学部・歯学部附属病院, 講師
2007: Okayama University, 医学部歯学部・附属病院, 助教
2006: 岡山大学, 医学部・歯学部附属病院, 助手 Less
Review Section/Research Field
Principal Investigator
Periodontal dentistry / Basic Section 57030:Conservative dentistry-related / Conservative dentistry / Periodontology
Except Principal Investigator
Periodontal dentistry / Periodontology / Basic Section 57030:Conservative dentistry-related / Conservative dentistry
Keywords
Principal Investigator
歯周組織 / 遺伝子導入 / 歯根膜 / インテグリン / 歯髄 / 炎症・再生 / RNA干渉 / 炎症性シグナル分子 / 細胞死 / 歯髄炎症 … More / 炎症性サイトカイン / siRNA / 細胞分化 / RhoA-ROCKシグナル / Y-27632 / 遺伝子発現 / RhoA / ROCK / Rho / Rho-kinase / ストレスファイバー / 細胞周期 / 細胞増殖・分化 / 細胞遊走 / 再生医学 / 細胞外基質 / 増殖因子 / 微小環境 / 幹細胞 / 歯周組織再生 / 細胞外小胞 / 侵襲性歯周炎 / マイクロRNA / プロテオーム … More
Except Principal Investigator
歯肉上皮細胞 / 歯周病 / 歯周炎 / 根尖性歯周炎 / 骨芽細胞 / IL-1 / ラミニン / 病巣治癒 / インターロイキン1α / 根尖病巣 / 冶癒 / MAPK / インターロイキン1a / 細胞増殖活性 / 細胞接着活性 / TGF-β / インテグリン / 細胞外基質 / Smad2 / Aggregatibacter actinomycetemcomitans / 細胞接着因子 / 細胞外マトリックス / Aggregatibacter ac / フィブロネクチン / Actinobacillus actinomycetemcomitans / 細胞接着 / E-cadherin / 細胞増殖 / 感染 / 顎骨壊死 / BP製剤 / 口内炎 / 唾液腺 / activin / follistatin / 炎症 / サイトカイン / HMGB1 / マクロファージ / 好中球 / 炎症性サイトカイン / 抗体療法 / 歯学 / 免疫学 / 遺伝子 / 炎症性老化 / サルコペニア / 慢性炎症 / IL-6 / 糖尿病 / 歯周組織再生 / 線維芽細胞増殖因子 / コラーゲン結合型タンパク / 水平性骨吸収 / 塩基性線維芽細胞増殖因子 / コラーゲン結合タンパク質 / 非臨床試験 / コラーゲン結合FGF-2 / 増殖因子 / ドラッグデリバリーシステム Less
  • Research Projects

    (13 results)
  • Research Products

    (25 results)
  • Co-Researchers

    (26 People)
  •  細胞外小胞の口腔トロピズムを基軸とする侵襲性歯周炎の病態解明と診断への応用展開Principal Investigator

    • Principal Investigator
      山本 直史
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57030:Conservative dentistry-related
    • Research Institution
      Okayama University
  •  Development of periodontal tissue regeneration therapy for horizontal alveolar bone resorption with collagen-binding FGF-2

    • Principal Investigator
      高柴 正悟
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57030:Conservative dentistry-related
    • Research Institution
      Okayama University
  •  Investigation of integrin peptide therapy regulating stem cell niche for periodontal regenerationPrincipal Investigator

    • Principal Investigator
      Yamamoto Tadashi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57030:Conservative dentistry-related
    • Research Institution
      Okayama University
  •  Elucidation of pathology of periodontal disease, sarcopenia, and diabetes centered on inflammation-aging

    • Principal Investigator
      Kobayashi Hiroya
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57030:Conservative dentistry-related
    • Research Institution
      Okayama University
  •  Functional analysis of HMGB1 as an inflammatory mediator in periodontitis

    • Principal Investigator
      YAMASHIRO KEISUKE
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Periodontology
    • Research Institution
      Okayama University
  •  Induction of Migration of Periodontal Ligament Cells by Selective Regulation of Integrin ExpressionPrincipal Investigator

    • Principal Investigator
      Yamamoto Tadashi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Periodontology
    • Research Institution
      Okayama University
  •  唾液腺体性幹細胞とiPS細胞を用いた唾液腺機能再生に関する研究

    • Principal Investigator
      峯柴 淳二
    • Project Period (FY)
      2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Periodontology
    • Research Institution
      Okayama University
  •  Construction of the prevention system of a Bisphosphonate-Related Osteonecrosis of the Jaw judging from an intraoral infection degree

    • Principal Investigator
      HATANAKA KAZU
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Periodontal dentistry
    • Research Institution
      Okayama University
  •  Cell cycle atlas of periodontiumPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Tadashi
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Periodontal dentistry
    • Research Institution
      Okayama University
  •  The molecular biological analysis of the mechanism for cell adhesion mediated by growth factor in human gingival epithelial cells

    • Principal Investigator
      YAMASHIRO Keisuke
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Periodontal dentistry
    • Research Institution
      Okayama University
  •  Healing mechanism of rat experimental periapical lesions targeting laminin γ2 expression

    • Principal Investigator
      HATANAKA Kazu
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Conservative dentistry
    • Research Institution
      Okayama University
  •  Investigation of the mechanisms of osteogenic differentiation by RhoA in periodontal ligament cells for cell transplantationPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Tadashi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Periodontal dentistry
    • Research Institution
      Okayama University
  •  創傷歯髄から単離した新規遺伝子FIP-2による歯髄炎症のコントロール法の探索Principal Investigator

    • Principal Investigator
      山本 直史
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Conservative dentistry
    • Research Institution
      Okayama University

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2010 2009

All Journal Article Presentation

  • [Journal Article] Analysis of subgingival microbiota in monozygotic twins with different severity and progression risk of periodontitis2022

    • Author(s)
      Yamamoto Tadashi、Taniguchi Makoto、Matsunaga Kazuyuki、Kawata Yusuke、Kawamura Mari、Okubo Keisuke、Yamashiro Keisuke、Omori Kazuhiro、Takashiba Shogo
    • Journal Title

      Clinical Case Reports

      Volume: 10

    • DOI

      10.1002/ccr3.5725

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H03119
  • [Journal Article] コラーゲン結合型塩基性線維芽細胞増殖因子を用いた水平性骨吸収に対する歯周組織再生療法の開発2021

    • Author(s)
      中村心,伊東孝,岡本憲太郎,美間健彦,内田健太郎,山本直史,松下治,高柴正悟
    • Journal Title

      日本歯科医学会会誌

      Volume: 40 Pages: 78-78

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03831
  • [Journal Article] Anti-HMGB1 neutralizing antibody attenuates periodontal inflammation and bone resorption in a murine periodontitis model.2018

    • Author(s)
      Yoshihara-Hirata Chiaki、Yamashiro Keisuke、Yamamoto Tadashi、Aoyagi Hiroaki、Ideguchi Hidetaka、Kawamura Mari、Suzuki Risa、Ono Mitsuaki、Wake Hidenori、Nishibori Masahiro、Takashiba Shogo
    • Journal Title

      Infect Immun.

      Volume: 86

    • DOI

      10.1128/iai.00111-18

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H06994, KAKENHI-PROJECT-16K20670, KAKENHI-PROJECT-18K17050, KAKENHI-PROJECT-16K11624
  • [Journal Article] HMGB1-induced inflammatory response promotes bone healing in murine tooth extraction socket.2018

    • Author(s)
      Aoyagi Hiroaki、Yamashiro Keisuke、Hirata-Yoshihara Chiaki、Ideguchi Hidetaka、Yamasaki Mutsuyo、Kawamura Mari、Yamamoto Tadashi、Kochi Shinsuke、Wake Hidenori、Nishibori Masahiro、Takashiba Shogo
    • Journal Title

      Journal of Cellular Biochemistry

      Volume: - Pages: 5481-5490

    • DOI

      10.1002/jcb.26710

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H06994, KAKENHI-PROJECT-16K20670, KAKENHI-PROJECT-18K17050
  • [Journal Article] Overexpression of Smad2 Inhibits Proliferation of Gingival Epithelial Cells2014

    • Author(s)
      Shimoe M, Yamamoto T, Shiomi N, Tomikawa K, Hongo S, Yamashiro K, Yamaguchi T, Maeda H, Takashiba S
    • Journal Title

      J Periodontal Res

      Volume: 49(3) Pages: 290-8

    • DOI

      10.1111/jre.12106

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659977
  • [Presentation] 侵襲性歯周炎の血液診断マーカー候補となる細胞外小胞由来マイクロRNAとその炎症誘導機構.2021

    • Author(s)
      森彩乃,山本直史,井手口英隆,河村麻理,河本美奈,伊東昌洋,小野喜章,中山真彰,山城圭介,大森一弘,高柴正悟.
    • Organizer
      第42回 日本炎症・再生医学会
    • Data Source
      KAKENHI-PROJECT-21H03119
  • [Presentation] インテグリンα3の選択的阻害による微小環境の構築と歯槽骨再生2020

    • Author(s)
      森彩乃,山本直史,河村麻理,井手口英隆,青柳浩明,中村心,岡本憲太郎,平井杏奈,山城圭介,大森一弘,高柴正悟
    • Organizer
      日本歯科保存学会
    • Data Source
      KAKENHI-PROJECT-18K09576
  • [Presentation] Collagen-binding basic fibroblast growth factor regenerates horizontal alveolar bone defect2019

    • Author(s)
      Nakamura S, Ito T, Okamoto K, Mima T, Uchida K, Siddiqui YD, Ito M, Tai M, Okubo K, Yamashiro K, Omori K, Yamamoto T, Matsushita O, Takashiba S
    • Organizer
      97th International Association of Dental Research, General Session & Exhibition
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03831
  • [Presentation] コラーゲン結合型塩基性線維芽細胞成長因子はコラーゲン基剤からの徐放によって歯周組織再生を促進する2019

    • Author(s)
      岡本憲太郎,中村心,伊東孝,Yasir Dilshad Siddiqui,美間健彦,内田健太郎,大森一弘,山本直史,松下治,高柴正悟
    • Organizer
      第150回日本歯科保存学会2019年度春季学術大会
    • Data Source
      KAKENHI-PROJECT-19H03831
  • [Presentation] Role of Integrin Isoforms during Migration of Periodontal Ligament Cells2017

    • Author(s)
      Kawamura M, Yamamoto T, Yamashiro K, Shimoe M., Yoshihara C, Ideguchi H, Aoyagi H, Omori K, Takashiba S
    • Organizer
      95th International Association for Dental Research
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2017-03-22
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26463134
  • [Presentation] 炎症性メディエーターHMGB1が歯槽骨治癒における血管新生の遺伝子発現を促進する2017

    • Author(s)
      青柳浩明,山城圭介,吉原千暁,井手口英隆,山本直史,河村麻理,下江正幸,本郷昌一,劉克約,西堀正洋,高柴正悟
    • Organizer
      第38回炎症再生医学会
    • Data Source
      KAKENHI-PROJECT-16K20670
  • [Presentation] インテグリンサブユニットの選択的制御による歯根膜細胞の遊走促進2017

    • Author(s)
      河村麻理,山本直史,山城圭介,平田千暁,青柳浩明,井手口英隆,大森一弘,高柴正悟
    • Organizer
      第146回日本歯科保存学会秋季大会
    • Place of Presentation
      青森
    • Year and Date
      2017-06-08
    • Data Source
      KAKENHI-PROJECT-26463134
  • [Presentation] HMGB1が歯槽骨治癒に及ぼす影響2017

    • Author(s)
      青柳浩明,山城圭介,吉原千暁,井手口英隆,山本直史,河村麻理,下江正幸,高柴正悟
    • Organizer
      第60回日本歯周病学会
    • Data Source
      KAKENHI-PROJECT-16K20670
  • [Presentation] 実験的歯周炎モデルマウスにおける抗HMGB1抗体の歯周炎抑制効果2016

    • Author(s)
      吉原千暁,山城圭介,山本直史,井手口英隆,青柳浩明,下江正幸,本郷昌一,河村麻理,高柴正悟
    • Organizer
      第59回春季日本歯周病学会
    • Place of Presentation
      かごしま県民交流センター,鹿児島市
    • Year and Date
      2016-05-21
    • Data Source
      KAKENHI-PROJECT-16K20670
  • [Presentation] Osteogenic Differentiation Regulated by Rho-kinase in Periodontal Ligament Cells2016

    • Author(s)
      山本直史
    • Organizer
      第37回岡山歯学会学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2016-10-16
    • Invited
    • Data Source
      KAKENHI-PROJECT-26463134
  • [Presentation] インテグリン発現による歯根膜細胞の遊走制御2016

    • Author(s)
      河村麻理,山本直史,山城圭介,吉原千暁,本郷昌一,下江正幸,大森一弘,高柴正悟
    • Organizer
      第59回春季日本歯周病学会学術大会
    • Place of Presentation
      鹿児島
    • Year and Date
      2016-05-20
    • Data Source
      KAKENHI-PROJECT-26463134
  • [Presentation] Anti-HMGB1 neutralizing antibody attenuates cytokine secretion and progression of periodontitis2016

    • Author(s)
      C. YOSHIHARA,K. YAMASHIRO,T. YAMAMOTO,H. IDEGUCHI,H. AOYAGI,M. SHIMOE,S. HONGO,M. KAWAMURA,K. Liu,M. NISHIBORI,S. TAKASHIBA,
    • Organizer
      IADR/APR General Session & Exhibition
    • Place of Presentation
      COEX Convention Center, Korea, Seoul
    • Year and Date
      2016-06-22
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K20670
  • [Presentation] ROCK阻害剤は歯根膜細胞の遊走を促進する2015

    • Author(s)
      河村麻理,山本直史,吉原千暁,松永一幸,井手口英隆,本郷昌一,下江正幸,大森一弘,高柴正悟
    • Organizer
      第142回日本歯科保存学会春季大会
    • Place of Presentation
      北九州
    • Year and Date
      2015-06-25
    • Data Source
      KAKENHI-PROJECT-26463134
  • [Presentation] Smad2 and ROCK signaling as Potential Therapeutic Targets for Periodontal Regeneration2015

    • Author(s)
      Tadashi Yamamoto
    • Organizer
      63rd Japanese Association for Dental Research
    • Place of Presentation
      福岡
    • Year and Date
      2015-10-30
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26463134
  • [Presentation] グリチルリチン酸 経口投与によるin vivo 歯周組織治癒効果2014

    • Author(s)
      井手口英隆,山城圭介,山本直史,本郷昌,下江正幸,高知信介,青柳浩明,吉原千暁,河村麻里,前田博史,高柴正悟
    • Organizer
      第57回日本歯周病学会春季学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2014-05-23
    • Data Source
      KAKENHI-PROJECT-23659977
  • [Presentation] グリチルリチン酸 経口投与によるin vivo歯周組織治癒効果2014

    • Author(s)
      井手口英隆,山城圭介,山本直史,本郷昌一,下江正幸,高知信介,青柳浩明,吉原千暁,河村麻里,前田博史,高柴正悟
    • Organizer
      第57回日本歯周病学会春季学術大会
    • Place of Presentation
      岐阜
    • Data Source
      KAKENHI-PROJECT-23659977
  • [Presentation] Osteogenic differentiation regulated by Rho kinase in periodontal ligament cells2010

    • Author(s)
      Yamamoto T
    • Organizer
      88th General Session of the International Association for Dental Research
    • Place of Presentation
      Spain, Barcelona
    • Year and Date
      2010-07-15
    • Data Source
      KAKENHI-PROJECT-20592429
  • [Presentation] Osteogenic differentiation regulated by Rho kinase in periodontal ligament cells.2010

    • Author(s)
      山本直史
    • Organizer
      88th General Session of the International Association for Dental Research
    • Place of Presentation
      Spain、 Barcelona
    • Year and Date
      2010-07-15
    • Data Source
      KAKENHI-PROJECT-20592429
  • [Presentation] Rho kinasesによる?歯根膜細胞の分化制御2009

    • Author(s)
      山本直史
    • Organizer
      第130回日本歯科保存学会春季大会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2009-06-11
    • Data Source
      KAKENHI-PROJECT-20592429
  • [Presentation] Rho kinasesによる歯根膜細胞の分化制御2009

    • Author(s)
      山本直史
    • Organizer
      第130回日本歯科保存学会春季大会
    • Place of Presentation
      札幌
    • Year and Date
      2009-06-11
    • Data Source
      KAKENHI-PROJECT-20592429
  • 1.  TAKASHIBA Shougo (50226768)
    # of Collaborated Projects: 12 results
    # of Collaborated Products: 19 results
  • 2.  YAMASHIRO Keisuke (30581087)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 10 results
  • 3.  HATANAKA Kazu (50362992)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  SHIMOE Masayuki (60580264)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 5.  YAMAGUCHI Tomoko (90580267)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 6.  NARUISHI Koji (00346446)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  MINESHIBA Junji (00509383)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  Kobayashi Hiroya (20710651)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  IDEGUCHI Hidetaka (80779421)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 10.  KAKO Aya (60448230)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  SHIOMI Nobuyuki (90432632)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  SONOYAMA Wataru (40325121)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  AOYAGI Hiroaki (10814501)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 14.  KOCHI Shinsuke (70803138)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 15.  WAKE Hidenori (60570520)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 16.  NISHIBORI Masahiro (50135943)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 17.  大森 一弘 (20549860)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  松下 治 (00209537)
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  • 19.  伊東 孝 (30636238)
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  • 20.  平山 晴子 (40635257)
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  • 21.  美間 健彦 (80596437)
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  • 22.  江口 傑徳 (20457229)
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  • 23.  宮地 孝明 (40550314)
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  • 24.  江國 大輔 (70346443)
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  • 25.  KIMURA Aya
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  • 26.  大野 充昭
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