Matsushita Osamu 松下治

… Alternative Names

Researcher Number	00209537
Other IDs
Affiliation (Current)	2019: 岡山大学, 医歯薬学総合研究科, 教授
Affiliation (based on the past Project Information) *help	2016 – 2019: 岡山大学, 医歯薬学総合研究科, 教授 2016: 岡山大学, 大学院医歯薬学総合研究科, 教授 2012 – 2016: 岡山大学, 医歯(薬)学総合研究科, 教授 2007 – 2012: Kitasato University School of Medicine, Department of Microbiology & Parasitology, Professor 2003 – 2006: Kagawa University(Faculty of Medicine), Molecular Microbiology, Assistant Professor, 医学部, 助教授 … More
Review Section/Research Field	Principal Investigator Bacteriology (including Mycology) / Bacteriology (including Mycology) / Bacteriology (including mycology) / Basic Section 49050:Bacteriology-related Except Principal Investigator Bacteriology (including Mycology) / Orthopaedic surgery / Bacteriology (including Mycology) / Biomedical engineering/Biological material science / Plastic surgery / 細菌学 … More
Keywords	Principal Investigator コラーゲン結合ドメイン / 骨新生 / 再生医療 / collagen-binding domain / 細菌性コラゲナーゼ / Clostridium perfringens / コラゲナーゼ / 細菌毒素 / 細胞外マトリックス / collagenase … More Except Principal Investigator Clostridium perfringens / ウェルシュ菌 / ウエルシュ菌 / ホスホリパーゼC / 転写調節 / phospholipase C / phased A-tracts / bent DNA / ε毒素 / Receptor / Epsilon-toxin / フェレドキシン / バイオリアクター / ベントDNA / 融合タンパク / コラーゲン / コラーゲン結合型成長因子 / 間葉系幹細胞 / 細菌 / α毒素 / DNA結合蛋白 / 遺伝子発現 / RNAポリメラーゼ / RNA polymerase / Epsilon-Toxin / CaM kinase II / LTP / NMDA / Lipid rafts / Nephrotoxicity / MDCK cell / Histopathology / 脂質ラフト / イプシロン毒素 / Bent DNA / LrpC / 成長因子 / 水素ガス / ガス産生 / ヒドロゲナーゼ / 酪酸 / 遺伝子投与 / pyruvate:ferredoxin酸化還元酵素 / Clostridium perfringerns / クロストリジウム / 発現ベクター / シアリダーゼ / コラゲナーゼ / Ferredoxin gene / Expression vector / Sialidase / Collagenase / Transcriptional fusion / Phased A-tracts / Curved DNA / 材料工学・処理 / 組織移植 / 関節機能再建術 / 金属表面加工 / 副甲状腺ホルモン / 繊維芽細胞成長因子 / 細胞・組織工学 / 積層型高密度培養 / コラーゲン細線維 / 血管再生 / PK15細胞 / ePTFE人工血管 / INTERGARD人工血管 / PLAシート / 人工血管 / CBD-cytokine / PEAC細胞 / HepG2細胞 / アルブミン / 免疫不全マウス / 人工骨膜 / 細胞積層技術 / 人工骨膜組織 / 機能性人工骨膜 / 運動器再生医療 / 細菌コラゲナーゼ / 塩基性線維芽細胞増殖因子 / コラーゲン結合ドメイン / 運動器再生 / 再生医学 / コラーゲン材料 / リンパ管新生 / リンパ浮腫 / リンパ管再生 / VEGF-C / 融合蛋白 / マイコプラズマ肺炎 / Mycoplasma pneumoniae / 間接螢光抗体法 / ラテックス凝集法 / DNAプロ-ブ法 / 咽頭スワブ / 臨床検査診断 / 間接蛍光抗体法 / ラテックス凝集反応 / DNA-プロ-ブ / Mycoplasma pheumoniae / DNAプロ-ブ / Mycoplasma pneumonia / Mycoplasmal Pneumonia / Indirect Immunofluorescence Test / Latex Agglutination Test / DNA-probe Test / Respiratory Exudates / Laboratory Diagnosis / Throat Swabs / 折れ曲がりDNA / Clostridium / C.peerfringens / alpha-toxin / DNA binding protein / gene regulation / DNA結合タンパク / 遺伝子クローニング / 細菌毒素 / 分子生物学 / 細菌の遺伝子発現 / DNA-binding protein / Gene cloning / Phospholipase C / Bacterial toxin / Molecular biology / UPエレメント / transcriptional regulation / レセプター / 毒素複合体 / シナプトソーム / 免疫染色 / 膜可溶化 / Toxin complex / Synaptosome / Immunostaining / Membrane solubilization / Calbrain / 脳 / S-100 / 低体温 / アルコール依存症 / カルシウム結合蛋白質 / 記憶 / Ca^<2+> / calmodulin-dependent protein kinase II / calcineurin / NMR / calbrain / S100 / brain / hypothermia / alcoholism / Histoparhology / Immunohistochemistry / 構造解析 / 腸性毒素血症 / モノクローナル抗体 / 膜孔形成型毒素 / Immunohistochemsitry / 血小板凝集 / シグナル伝達 / ガングリオシド / スフィンゴミエリン / 血小板 / 脂質クラフト / スフィンゴ糖脂質 / セラミド / Alpha-toxin / Lipid raft / Platelet aggregation / Signal transduction / Ganglioside / Sphingomyelin / αサブユニット / 共結晶化 / 共結晶 / regulation of transcription / α subunit / co-crystallization / イブシロン毒素 / Transcriptional factor / Gene expression / ボツリヌス神経毒素 / 神経障害性疼痛 / 疼痛抑制 / SNAP-25 / 同種骨軟骨移植 / 成長因子固相化技術 / 成長因子固相化 / 組織保存 / 同種移植 / 骨軟骨移植 / 同種骨軟骨組織移植 / コラーゲン結合蛋白 / 細胞シート / 骨形成タンパク / 後側方固定術 / 移植・再生医療 / 細胞・組織 / 歯周組織再生 / コラーゲン結合FGF-2 / 水平性骨吸収 / 増殖因子 / ドラッグデリバリーシステム / ヘリコバクター・ピロリ / 若年者 / 除菌 / 腸内細菌叢 / 胃炎 / 脱細胞化 / アンカリング / 小腸 / 心筋 / decellularization / recellularization / collagen-binding domain / scaffold / 局所硬化ゲル Less

Development of periodontal tissue regeneration therapy for horizontal alveolar bone resorption with collagen-binding FGF-2Ongoing
- Principal Investigator
  
  高柴正悟
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Okayama University
ピロリ菌除菌療法における腸内エコシステム破綻のメカニズムと制御Ongoing
- Principal Investigator
  
  岡田裕之
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Okayama University
Elucidation of substrate recognition mechanism of bacterial collagenases to develop angiogenic drug seedsPrincipal InvestigatorOngoing
- Principal Investigator
  
  松下治
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Okayama University
腸管スキャフォールドとコラーゲン結合型成長因子を用いた拍動性グラフトの創成Ongoing
- Principal Investigator
  
  笠原真悟
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Okayama University
注入型局所硬化ゲルを用いた幹細胞・成長因子送達による新規難治性骨折治療法の開発Ongoing
- Principal Investigator
  
  内田健太郎
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kitasato University
高齢者脊椎固定術において確実な骨癒合を実現する機能性間葉系幹細胞シートの創生Ongoing
- Principal Investigator
  
  井上玄
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kitasato University
Musculoskeletal regeneration using Growth factor-anchored materials
- Principal Investigator
  
  Masashi Takaso
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kitasato University
Structure-function analysis of bacterial toxins in tissue destruction to apply their functional domains to regenerative medicinePrincipal Investigator
- Principal Investigator
  
  MATSUSHITA Osamu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Okayama University
Development of collagen binding VEGF-C for lymphangiogenesis
- Principal Investigator
  
  Matsumoto Hiroshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Plastic surgery
- Research Institution
  Okayama University
Clarification of molecular mechanisms underlying the analgesic effect of botulinum toxin and applied study
- Principal Investigator
  
  YAMAMOTO YUMIKO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Okayama University
Establishment of novel osteochondral allografting combined with growth factor- collagen-binding domain fusion technology
- Principal Investigator
  
  Onuma Kenji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kitasato University
Development of novel fracture healing methods using artificical perioteum and collagen-binding growth factor containing a collagen-binding domain from Clostridium histolyticum collagenase
- Principal Investigator
  
  TAKASO Masashi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kitasato University
Preclinical study to elucidate molecular mechanism of matrix anchoring using bacterial proteinsPrincipal Investigator
- Principal Investigator
  
  MATSUSHITA Osamu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Okayama University
  Kitasato University
Generating artificial parenchymal and hollow organs fabricated with collagen fibrils,various cells, and cytokines using a bioreactor that we have developed
- Principal Investigator
  
  ADACHI Eijiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kitasato University
Basic science technology study of new revision total hip arthroplasty using a fusion protein and the nanowire processing
- Principal Investigator
  
  NARUSE Kouji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kitasato University
Translational research on a drug delivery system using substrate binding domain derived from bacterial collagenasesPrincipal Investigator
- Principal Investigator
  
  MATSUSHITA Osamu
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kitasato University
A study on a mechanism for the transcriptional regulation of an epsilon-toxin gene by a novel type of bent DNA
- Principal Investigator
  
  OKABE Akinobu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kagawa University
Interdisciplinary study on the calcium-dependent conformational change of collagen-binding domain from clostridial collagenasesPrincipal Investigator
- Principal Investigator
  
  MATSUSHITA Osamu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kitasato University
  Kagawa University
A study on the molecular mechanism of substrate recognition by Clostridial collagenasesPrincipal Investigator
- Principal Investigator
  
  MATSUSHITA Osamu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  KAGAWA UNIVERSITY
A study on the mechanism underlying the action of Clostridium perfringens alpha- and epsilon-toxins to membrane lipid rafts
- Principal Investigator
  
  OKABE Akinobu
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  KAGAWA UNIVERSITY
  香川大学(医学部)
Studies on the law temperature-dependent enhancement of transcription by a bent DNA
- Principal Investigator
  
  KATAYAMA Seiichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Faculty of Science, Okayama University of Science
特殊ベント・プロモーターを利用した新規高発現ベクターの構築
- Principal Investigator
  
  岡部昭延
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  香川大学(医学部)
Basic research on the development of novel vaccines with collagen-anchoring potency.Principal Investigator
- Principal Investigator
  
  MATSUSHITA Osamu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kagawa University(Faculty of Medicine)
Study on structure biology and molecular pathology of Clostridium perfringens epsilon-toxin
- Principal Investigator
  
  OKABE akinobu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kagawa Medical University
水素ガス産生用ウエルシュ菌バイオリアクター開発のための基礎研究
- Principal Investigator
  
  OKABE Akinobu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  香川医科大学
Drug design based on the three-dimensional structure of collagen-binding domain, and its applicationPrincipal Investigator
- Principal Investigator
  
  MATSUSHITA Osamu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  香川医科大学
Studies on neurotropism of Clostridium perfringens epsilon-toxin and molecular mechanism of its toxicity toward neuronal cells
- Principal Investigator
  
  OKABE Akinobu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kagawa Medical University
Neuron specific calcium-binding Protein, calbrain, is involved in memory formation.
- Principal Investigator
  
  TOKUDA Masaaki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  KAGAWA MEDICAL UNIVERSITY
Function of promoter upstream bent DNA of the Clostridium perfringens phospholipase C gene
- Principal Investigator
  
  KATAYAMA Seiichi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kagawa Medical University
コラーゲン結合ドメインによるガス壊疸の発症予防Principal Investigator
- Principal Investigator
  
  松下治
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  香川医科大学
Analysis of the activation and mode of action of Clostridium perfringens ε-toxinPrincipal Investigator
- Principal Investigator
  
  MATSUSHITA Osamu, 南純三朗
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kagawa Medical University
ウェルシュ菌MSCLチャンネルによる病原遺伝子発現制御に関する研究Principal Investigator
- Principal Investigator
  
  松下治
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  香川医科大学
Study on function of phospholipase C gene binding protein from Clostridium perfringens
- Principal Investigator
  
  OKABE Akinobu
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kagawa Medical University
ガス壊疽菌コラゲナーゼの反応機構の解析Principal Investigator
- Principal Investigator
  
  松下治
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  香川医科大学
Function of protein (s) which can bind to an alpha-toxin gene of Clostridium perfringens
- Principal Investigator
  
  OKABE Akinobu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kagawa Medical School
Developmental Studies on the Laboratory diagnosis at an early stage of Mycoplasam pneumoniae-infection (mycoplasmal pneumonia)
- Principal Investigator
  
  KANEMASA Yasuhiro
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  細菌学
- Research Institution
  Okayama University

[Journal Article] Acceleration of bone regeneration of horizontal bone defect in rats using collagen-binding basic fibroblast growth factor combined with collagen scaffolds.2019
- Author(s)
  Nakamura Shin、Ito Takashi、Okamoto Kentaro、Mima Takehiko、Uchida Kentaro、Siddiqui Yasir D.、Ito Masahiro、Tai Masako、Okubo Keisuke、Yamashiro Keisuke、Omori Kazuhiro、Yamamoto Tadashi、Matsushita Osamu、Takashiba Shogo
- Journal Title
  
  J. Periodontol.
  
  Volume: - Pages: 1-10
- DOI
  10.1002/jper.18-0674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08830, KAKENHI-PROJECT-18K07111
[Journal Article] Basic Fibroblast Growth Factor-Anchored Multilayered Mesenchymal Cell Sheets Accelerate Periosteal Bone Formation.2018
- Author(s)
  Uchida K, Inoue G, Matsushita O, Horikawa K, Sekiguchi H, Saito W, Takano S, Fujimaki H, Miyagi M, Takaso M.
- Journal Title
  
  BioMed Research International
  
  Volume: 4371460 Pages: 1-8
- DOI
  10.1155/2017/4371460
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10982, KAKENHI-PROJECT-17K10983, KAKENHI-PROJECT-17K16701, KAKENHI-PROJECT-15K20015
[Journal Article] Ca2+-induced orientation of tandem collagen binding domains from clostridial collagenase ColG permits two opposing functions of collagen fibril formation and retardation.2018
- Author(s)
  Caviness P, Bauer R, Tanaka K, Janowska K, Roeser JR, Harter D, Sanders J, Ruth C, Matsushita O, Sakon J.
- Journal Title
  
  FEBS J.
  
  Volume: 285 Pages: 3254-3269
- DOI
  10.1111/febs.14611
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07111
[Journal Article] Oriented collagen tubes combined with basic fibroblast growth factor promote peripheral nerve regeneration in a 15 mm sciatic nerve defect rat model.2017
- Author(s)
  Fujimaki H, Uchida K, Inoue G, Miyagi M, Nemoto N, Saku T, Isobe Y, Inage K, Matsushita O, Yagishita S, Sato J, Takano S, Sakuma Y, Ohtori S, Takahashi K, Takaso M.
- Journal Title
  
  J Biomed Mater Res A.
  
  Volume: 105 Pages: 8-14
- DOI
  10.1002/jbm.a.35866
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293341, KAKENHI-PROJECT-26460527, KAKENHI-PROJECT-15K20015
[Journal Article] Effect of Freeze-Dried Allograft Bone With Human Basic Fibroblast Growth Factor Containing a Collagen-Binding Domain From Clostridium histolyticum Collagenase on Bone Formation After Lumbar Posterolateral Fusion Surgery in Rats2017
- Author(s)
  Inoue G, Uchida K, Matsushita O, Fujimaki H, Saito W, Miyagi M, Sekiguchi H, Nishi N, Ohtori S, Yogoro M, Takaso M.
- Journal Title
  
  Spine (Phila Pa 1976)
  
  Volume: 印刷中 Pages: 995-1001
- DOI
  10.1097/brs.0000000000002074
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293341, KAKENHI-PROJECT-26460527, KAKENHI-PROJECT-26861209, KAKENHI-PROJECT-15K20015, KAKENHI-PROJECT-17K10982, KAKENHI-PROJECT-17K16701
[Journal Article] Acceleration of bone formation during fracture healing by poly(Pro-Hyp-Gly)10 and basic fibroblast growth factor containing polycystic kidney disease and collagen-binding domains from Clostridium histolyticum collagenase.2016
- Author(s)
  Sekiguchi H, Uchida K, Inoue G, Matsushita O, Saito W, Aikawa J, Tanaka K, Fujimaki H, Miyagi M, Takaso M.
- Journal Title
  
  J Biomed Mater Res A.
  
  Volume: 104 Pages: 1372-1378
- DOI
  10.1002/jbm.a.35670
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K20015, KAKENHI-PROJECT-26861209, KAKENHI-PROJECT-26861210, KAKENHI-PROJECT-26293341, KAKENHI-PROJECT-26460527
[Journal Article] Acceleration of callus formation during fracture healing using basic fibroblast growth factor-kidney disease domain-collagen binding domain fusion protein combined with allogenic demineralized bone powder.2015
- Author(s)
  Saito W, Uchida K, Matsushita O, Inoue G, Sekiguchi H, Aikawa J, Fujimaki H, Takaso M.
- Journal Title
  
  J Orthop Surg Res
  
  Volume: -
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293341
[Journal Article] Cross-excitation in peripheral sensory ganglia is associated with pain transmission2015
- Author(s)
  Omoto K, Maruhama K, Terayama R, Yamamoto Y, Matsushita O, Sugimoto T, Oguma K, Matsuka Y
- Journal Title
  
  Toxins
  
  Volume: 7 Pages: 2906-2917
- DOI
  10.3390/toxins7082906
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26350499, KAKENHI-PROJECT-26293412
[Journal Article] Structures of three polycystic kidney disease-like domains from Clostridium histolyticum collagenases ColG and ColH.2015
- Author(s)
  Bauer R, Janowska K, Taylor K, Jordan B, Gann S, Janowski T, Latimer EC, Matsushita O, Sakon J.
- Journal Title
  
  Acta Crystallogr D Biol Crystallogr.
  
  Volume: 71 Pages: 565-577
- DOI
  10.1107/s1399004714027722
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460527
[Journal Article] Enhancement of periosteal bone formation by basic fibroblast-derived growth factor containing polycystic kidney disease and collagen-binding domains from Clostridium histolyticum collagenase．2015
- Author(s)
  Uchida K, Matsushita O, Nishi N, Inoue G, Horikawa K, Takaso M. ．
- Journal Title
  
  J Tissue Eng Regen Med
  
  Volume: in press
- DOI
  10.1002/term.2019
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24791560, KAKENHI-PROJECT-25670659, KAKENHI-PROJECT-26293341
[Journal Article] Acceleration of callus formation during fracture healing using basic fibroblast growth factor-kidney disease domain-collagen-binding domain fusion protein combined with allogenic demineralized bone powder.2015
- Author(s)
  Saito W, Uchida K, Matsushita O, Inoue G, Sekiguchi H, Aikawa J, Fujimaki H, Takaso M.
- Journal Title
  
  J Orthop Surg Res
  
  Volume: 10 Pages: 59-59
- DOI
  10.1186/s13018-015-0201-0
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460527, KAKENHI-PROJECT-26861210
[Journal Article] Acceleration of callus formation during fracture healing using basic fibroblast growth factor-kidney disease domain-collagen binding domain fusion protein combined with allogenic demineralized bone powder.2015
- Author(s)
  Saito W, Uchida K, Matsushita O, Inoue G, Sekiguchi H, Aikawa J, Fujimaki H, Takaso M.
- Journal Title
  
  J Orthop Surg Res
  
  Volume: -
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25670659
[Journal Article] Direct cytocidal effect of galectin-9 localized on collagen matrices on human immune cell lines.2014
- Author(s)
  Fukata Y, Itoh A, Nonaka Y, Ogawa T, Nakamura T, MatsushitaO, Nishi N
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1840(6) Pages: 1892-1901
- DOI
  10.1016/j.bbagen.2014.01.019
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23590516, KAKENHI-PROJECT-26460527
[Journal Article] Treatment and prevention of chemotherapy-induced alopecia with PTH-CBD, a collagen-targeted parathyroid hormone analog, in a non-depilated mouse model2014
- Author(s)
  Katikaneni R, Ponnapakkam T, MatsushitaO, Sakon J, Gensure R
- Journal Title
  
  Anticancer Drugs
  
  Volume: 25(1) Pages: 30-38
- DOI
  10.1097/cad.0b013e3283650bff
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590516
[Journal Article] Acceleration of periosteal bone formation by human basic fibroblast growth factor containing a collagen-binding domain from Clostridium histolyticum collagenase2014
- Author(s)
  Uchida K, Matsushita O, Naruse K, Mima T, Nishi N, Hattori S, Ogura T, Inoue G, Tanaka K, Takaso M.
- Journal Title
  
  Journal of biomedical materials research Part A
  
  Volume: 102 Pages: 1737-1743
- DOI
  10.1002/jbm.a.34841
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23590516, KAKENHI-PROJECT-23790483, KAKENHI-PROJECT-24791560, KAKENHI-PROJECT-25670659, KAKENHI-PROJECT-26460527, KAKENHI-PROJECT-26861210
[Journal Article] Acceleration of bone union after structural bone grafts with collagen-binding basic fibroblast growth factor anchored-collagen sheet for critical-size bone defects.2014
- Author(s)
  Ueno M, Uchida K, Saito W, Matsushita O, Yogoro M, Nishi N, Ogura T, Hattori S, Inoue G, Tanaka K, Takahira N, Takaso M.
- Journal Title
  
  Biomed Mater.
  
  Volume: 9 Pages: 035014-035014
- DOI
  10.1088/1748-6041/9/3/035014
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460527, KAKENHI-PROJECT-26861210
[Journal Article] Acceleration of bone formation during fracture healing by injectable collagen powder and human basic fibroblast growth factor containing a collagen-binding domain from Clostridium histolyticum collagenase.2014
- Author(s)
  Saito W, Uchida K, Ueno M, MatsushitaO, Inoue G, Nishi N, Ogura T, Hattori S, Fujimaki H, Tanaka K, Takaso M
- Journal Title
  
  J Biomed Mater Res A.
  
  Volume: in press Pages: 3049-3055
- DOI
  10.1002/jbm.a.34974
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23590516, KAKENHI-PROJECT-24791560, KAKENHI-PROJECT-25670659, KAKENHI-PROJECT-26460527, KAKENHI-PROJECT-26861210
[Journal Article] Structural comparison of ColH and ColG collagen-binding domains from Clostridium histolyticum2013
- Author(s)
  Bauer R, Wilson JJ, Philominathan ST, Davis D, Matsushita O, Sakon J.
- Journal Title
  
  J Bacteriol
  
  Volume: 195 Pages: 318-327
- DOI
  10.1128/jb.00010-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590516
[Journal Article] Effects of CB-VEGF-A injection in rat flap models for improved survival2013
- Author(s)
  Akimoto M, Takeda A, Matsushita O, Inoue J, Sakamoto K, Hattori M, Kounoike N, Uchinuma E.
- Journal Title
  
  Plast Reconstr Surg
  
  Volume: 131 Pages: 717-725
- DOI
  10.1097/prs.0b013e3182818b34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590516
[Journal Article] A single injection of the anabolic bone agent, parathyroid hormone-collagen binding domain (PTH-CBD), results in sustained increases in bone mineral density for up to 12 months in normal female mice2012
- Author(s)
  Ponnapakkam T, Katikaneni R, Suda H, Miyata S, Matsushita O, Sakon J, Gensure RC.
- Journal Title
  
  Calcified tissue international
  
  Volume: 91 Pages: 196-203
- DOI
  10.1007/s00223-012-9626-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590516, KAKENHI-PROJECT-24590538
[Journal Article] Bacterial collagen-binding domain targets undertwisted regions of collagen2012
- Author(s)
  Philominathan ST, Koide T, Matsushita O, Sakon J.
- Journal Title
  
  Protein Sci
  
  Volume: 21 Pages: 1554-1565
- DOI
  10.1002/pro.2145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590516
[Journal Article] Treatment for chemotherapy-induced alopecia in mice using parathyroid hormone agonists and antagonists linked to a collagen binding domain2012
- Author(s)
  Katikaneni R, Ponnapakkam T, Suda H, Miyata S, Sakon J, MatsushitaO, Gensure RC
- Journal Title
  
  Int J Cancer
  
  Volume: 131(5)
- DOI
  10.1002/ijc.27379
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590516
[Journal Article] Probing the 3-D structure, dynamics, and stability of bacterial collagenase collagen binding domain (apo- versus holo-) by limited proteolysis MALDI-TOF MS.2012
- Author(s)
  Sides CR, Liyanage R, Lay JO Jr, Philominathan ST, Matsushita O, Sakon J
- Journal Title
  
  J. Am. Soc. Mass. Spectrom.
  
  Volume: 23(3) Pages: 505-519
- DOI
  10.1007/s13361-011-0309-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590516
[Journal Article] Prevention of chemotherapy-induced osteoporosis by cyclophosphamide with a long-acting form of parathyroid hormone.2011
- Author(s)
  Ponnapakkam T, Katikaneni R, Nichols T, Tobin G, Sakon J, Matsushita O, Gensure RC.
- Journal Title
  
  J. Endocrinol. Invest.
  
  Volume: 34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590516
[Journal Article] Monthly administration of a novel PTH-vollagen binding domain fusion protein is anabolic in mice. Calcif.2011
- Author(s)
  Ponnapakkam T., Katikaneni, R., Miller, E., Ponnapakkam, A., Suda, H., Miyata, S., Suva, L.J., JSakon, J., Matsushita, O., Gensure, R.C.
- Journal Title
  
  Tissue Int. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590452
[Journal Article] Monthly administration of a novel PTH-collagen binding domain fusion protein is anabolic in mice.2011
- Author(s)
  Ponnapakkam Tulasi, 他9名
- Journal Title
  
  Calcif. Tissue. Int.
  
  Volume: 88 Pages: 511-520
- DOI
  10.1007/s00223-011-9485-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300167, KAKENHI-PROJECT-23590516
[Journal Article] Prevention of chemotherapy-induced osteoporosis by cyclophosphamide with a long-acting form of parathyroid hormone2011
- Author(s)
  Ponnapakkam T, Katikaneni R, Nichols T, Tobin G, Sakon J, Matsushita O, Gensure RC
- Journal Title
  
  J Endocrinol Invest
  
  Volume: 34(11)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590516
[Journal Article] Unidirectional binding of clostridial collagenase to triple helical substrates.2009
- Author(s)
  Philominathan, S.T., Koide, T., Hamada, K., Yasui, H., Seifert, S., Matsushita, O., Sakon, J.
- Journal Title
  
  J.Biol.Chem. 284
  
  Pages: 10868-10876
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590452
[Journal Article] Development of a high-throughput screening system for the compounds that inhibit collagen-protein interactions.2009
- Author(s)
  Okano-Kosugi H, Matsushita O, Asada S, Herr AB, Kitagawa K, Koide T.
- Journal Title
  
  Anal.Biochem. 394
  
  Pages: 125-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590452
[Journal Article] Unidirectional binding of clostridial collagenase to triple helical substrates.2009
- Author(s)
  Philominathan ST, Koide T, Hamada K, Yasui H, Seifert S, Matsushita O, Sakon J.
- Journal Title
  
  J.Biol.Chem. 284
  
  Pages: 10868-10876
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590452
[Journal Article] Ca^<2+>-induced linker transformation leads to a compact and rigid collagen-binding domain of Clostridium histolyticum collagenase.2009
- Author(s)
  Philominathan ST, Matsushita O, Gensure R, Sakon J.
- Journal Title
  
  FEBS J. 276
  
  Pages: 3589-3601
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590452
[Journal Article] Development of a high-throughput screening system for the compounds that inhibit collagen-protein interactions.2009
- Author(s)
  Okano-Kosugi, H., Matsushita, O., Asada, S., Herr, A.B., Kitagawa, K., Koide, T.
- Journal Title
  
  Anal.Biochem. 394
  
  Pages: 125-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590452
[Journal Article] Ca2^+-induced linker transformation leads to a compact and rigid collagen-binding domain of Clostridium histolyticum collagenase.2009
- Author(s)
  Philominathan, S.T., Matsushita, O., Gensure, R., Sakon, J.
- Journal Title
  
  FEBS J. 276
  
  Pages: 3589-3601
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590452
[Journal Article] High-level expression of his-tagged clostridial collagenase in Clostridium perfringens.2008
- Author(s)
  Tamai, E., Miyata, S., Tanaka, H., Nariya, H., Suzuki, M., Matsushita, O., Hatano, N., Okabe, A.
- Journal Title
  
  Appl. Microbiol. Biotechnol. 80
  
  Pages: 627-635
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590452
[Journal Article] High-level expression of his-tagged clostridial collagenase in Clostridium perfringens.2008
- Author(s)
  Tamai, E., Miyata, S., Tanaka, H., Nariya, H., Suzuki,M., Matsushita, O., Hatano, N., Okabe, A.
- Journal Title
  
  Appl.Microbiol.Biotechnol. 80
  
  Pages: 627-635
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590452
[Journal Article] ^1H,^<13>C and ^<15>N resonace assignments of Ca^<2+> bound collagen-binding domain derived from a clostridial collagenase2008
- Author(s)
  Philominathan, S. T. L., Matsushita, O., Jordan, J. B., Sakon, J.
- Journal Title
  
  Biomol. NMR Assign. 2
  
  Pages: 127-129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590452
[Journal Article] 1H, 13C and 15N resonace assignments of Ca2^+-bound collagen-binding domain derived from a clostridial collagenase.2008
- Author(s)
  Philominathan, S.T.L., Matsushita, O., Jordan, J.B., Sakon, J.
- Journal Title
  
  Biomol.NMR Assign. 2
  
  Pages: 127-129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590452
[Journal Article] Changens in ganglioside content affect the binding of Clostridium perfringens epsilon-toxin to detergent-resistant membranes of Madin-Darby canine kidney cells.2005
- Author(s)
  Shimamoto S, Tamai E, Matsushita O, Minami J, Okabe A, Miyata S.
- Journal Title
  
  Microbiology and Immunology 49(3)
  
  Pages: 245-253
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390144
[Presentation] コラーゲン結合型塩基性線維芽細胞成長因子とコラーゲン基剤を用いた複合剤の歯周組織再生への応用2018
- Author(s)
  中村心、伊東孝、松下治、岡本憲太郎、美間健彦、内田健太郎、高柴正悟、他７名
- Organizer
  第61回秋季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-18K07111
[Presentation] Structural analysis of a matrix anchor in bacterial collagenase to develop a therapeutic to induce osteogenesis.2017
- Author(s)
  Osamu Matsushita, Kentaro Uchida, Hiroyuki Sekiguchi, Takehiko Mima, Kazuyoshi Goto, Yumiko Yamamoto, Kenji Yokota, Masashi Takaso, Ryan Bauer, Joshua Sakon
- Organizer
  第90回日本細菌学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-26460527
[Presentation] 新規コラーゲン結合型線維芽細胞増殖因子による骨形成促進法の開発2016
- Author(s)
  関口裕之、内田健太郎、井上玄、相川淳、斉藤亘、宮城正行、松下治、藤巻寿子、高野昇太郎、名倉直重、高相晶士.
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26293341
[Presentation] 合成コラーゲン様基剤とコラーゲン結合型線維芽細胞増殖因子を用いた複合剤による骨形成促進法の開発2016
- Author(s)
  濱本奈々，内田健太郎，関口裕之，美間健彦，後藤和義，山本由弥子，横田健治，高相晶士，松下　治
- Organizer
  第89回日本細菌学会総会
- Place of Presentation
  大阪府大阪市
- Year and Date
  2016-03-23
- Data Source
  KAKENHI-PROJECT-26460527
[Presentation] 細菌分子によるマトリックスアンカーリング機構を応用した骨形成促進法の開発2015
- Author(s)
  内田健太郎、松下　治、齋藤　亘、井上　玄、高相晶士
- Organizer
  第18回北里微生物アカデミー研究集会
- Place of Presentation
  北里大学（神奈川県相模原市）
- Year and Date
  2015-08-06
- Data Source
  KAKENHI-PROJECT-26293341
[Presentation] 細菌毒素の機能性ドメインを用いた新規再生医療用複合材料2015
- Author(s)
  松下　治，内田健太郎，西　望，小出隆規，Joshua Sakon
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  徳島県徳島市
- Year and Date
  2015-06-24
- Invited
- Data Source
  KAKENHI-PROJECT-26460527
[Presentation] Bone powder とコラーゲン結合型線維芽細胞増殖因子による骨折後の骨形成促進効果の検討.2014
- Author(s)
  斎藤　亘、内田健太郎、井上　玄、松下　治、大貫裕子、藤巻寿子、関口裕之、相川　淳、高平尚伸、高相晶士.
- Organizer
  第33回日本運動器移植・再生医学研究会
- Place of Presentation
  第一ホテル両国（東京都墨田区）
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-26293341
[Presentation] Drug delivery based on clostridial collagenase showed therapeutic effects in orthopedic surgery2014
- Author(s)
  松下治、美間健彦、山本由弥子、鈴木智典、横田憲二
- Organizer
  第87回日本細菌学会
- Place of Presentation
  東京都江戸川区船堀
- Data Source
  KAKENHI-PROJECT-23590516
[Presentation] Drug delivery based on clostridial collagenase showed therapeutic effects in orthopedic surgery2014
- Author(s)
  松下　治、美間健彦、山本由弥子、鈴木智典、横田憲治
- Organizer
  第87回日本細菌学会総会
- Place of Presentation
  東京都江戸川区船堀
- Data Source
  KAKENHI-PROJECT-23590516
[Presentation] Structural comparison od collagen- binding domains derived from Clostridium histolyticum collagenases2013
- Author(s)
  松下治、美間健彦、山本由弥子、鈴木智典、横田憲二
- Organizer
  第86回日本細菌学会
- Place of Presentation
  千葉県千葉市
- Data Source
  KAKENHI-PROJECT-23590516
[Presentation] ガス壊疽菌群コラゲナーゼの基質認識機構の解明と臨床応用2012
- Author(s)
  松下治、美間健彦、鈴木智典、山本由弥子、横田憲治、小出隆規、安達栄治郎、玉井栄治、宮田茂、南純三朗、岡部昭延
- Organizer
  第65回日本細菌学会中国・四国支部総会
- Place of Presentation
  徳島県徳島市
- Data Source
  KAKENHI-PROJECT-23590516
[Presentation] コラーゲン結合ドメインを持つヒトEGFが三次元培養皮膚モデルの表皮重層化に及ぼす影響2012
- Author(s)
  笠原薫、松下治、安達栄治郎、西山敏夫他1名
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22300167
[Presentation] Bacterial collagen-binding domains - Molecular basics and clinical applications2012
- Author(s)
  Osamu Matsushita, Takehiko Mima, Eijiro Adachi, Joshua Sakon, Nozomu Nishi, Takenori Miyashita, Nozomu Mori, Joe Inou1, Masakazu Hattori, Minekatsu Akimoto, Akira Takeda, Eiju Uchinuma
- Organizer
  第85回　日本細菌学会総会
- Place of Presentation
  長崎県長崎市
- Data Source
  KAKENHI-PROJECT-23590516
[Presentation] 細菌性コラゲナーゼの基質認識と臨床応用2012
- Author(s)
  松下治
- Organizer
  第三回愛媛微生物学ネットワークフォーラム
- Place of Presentation
  愛媛県松山市
- Year and Date
  2012-11-10
- Invited
- Data Source
  KAKENHI-PROJECT-23590516
[Presentation] Bacterial collagen-binding domains - Molecular basics and clinical applications2012
- Author(s)
  Osamu Matsushita, Takehiko Mima, Eijiro Adachi, Joshua Sakon, Nozomu Nishi, Takenori Miyashita, NozomuMori, JoeInoue, Masakazu Hattori, Minekatsu Akimoto, Akira Takeda, Eiju Uchinuma
- Organizer
  第85回日本細菌学会総会
- Place of Presentation
  長崎県長崎市
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-23590516
[Presentation] Bacterial collagen-binding domains-Molecular basis and clinical applications2012
- Author(s)
  松下治, 他3名
- Organizer
  第85回日本細菌学会総会
- Place of Presentation
  長崎新聞文化ホール(長崎県)
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-22300167
[Presentation] Medial application of clostridial toxins ; 2) Collagenases2011
- Author(s)
  松下治, 他10名
- Organizer
  第84回日本細菌学会総会
- Place of Presentation
  札幌コンベンションセンター(北海道)
- Data Source
  KAKENHI-PROJECT-22300167
[Presentation] ガス壊疽菌群コラゲナーゼの基質結合ドメインと再生医療への応用2010
- Author(s)
  松下治、西望、小杉日登美、小出隆規、安達栄治郎、坂本恵子、服部雅一
- Organizer
  第57回トキシンシンポジウム
- Place of Presentation
  滋賀県長浜市
- Year and Date
  2010-07-16
- Data Source
  KAKENHI-PROJECT-20590452
[Presentation] Collagen anchoring : From bacterial toxin to drug2010
- Author(s)
  Osamu Matsushita
- Organizer
  11th Joint Symposium Robert Koch Institute and The Kitasato Institute Kitasato University
- Place of Presentation
  北里大学薬学部コンベンションホール(東京都)
- Year and Date
  2010-10-26
- Data Source
  KAKENHI-PROJECT-20590452
[Presentation] コラーゲン結合ドメインの構造解析と薬物送達システムへの応用2010
- Author(s)
  松下治、宮田茂
- Organizer
  第83回日本細菌学会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2010-03-27
- Data Source
  KAKENHI-PROJECT-20590452
[Presentation] From bacterial toxin to drug.2010
- Author(s)
  Matsushita O., Collagen anchoring
- Organizer
  11th Joint Symposium Robert Koch Institute and The Kitasato Institute Kitasato University
- Place of Presentation
  東京都港区
- Year and Date
  2010-10-26
- Data Source
  KAKENHI-PROJECT-20590452
[Presentation] Substrate recognition of collagen-binding domains derived from bacterial collagenases2009
- Author(s)
  Matsushita O, Nishi N, Koide T, Philominathan STL, Sakon J Gensure RC, Iwashiro H, Adachi E
- Organizer
  8th Pan-pacific connective tissue societies symposium, 41st Annual meeting of the Japanese society of connective tissue research, 56th Annual meeting of the Japan matrix club
- Place of Presentation
  神奈川県逗子市
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-20590452
[Presentation] ガス壊疽菌群コラゲナーゼの基質結合様式と積層型人工組織作製への応用2009
- Author(s)
  松下治
- Organizer
  第56回トキキンシンポジウム
- Place of Presentation
  岐阜県岐阜市
- Year and Date
  2009-08-27
- Data Source
  KAKENHI-PROJECT-20590452
[Presentation] ガス壊疽菌群コラゲナーゼの基質認識機構と再生医学への応用2009
- Author(s)
  松下治、小出隆規、安達栄治郎
- Organizer
  第82回日本細菌学会総会
- Place of Presentation
  愛知県名古屋市
- Year and Date
  2009-03-12
- Data Source
  KAKENHI-PROJECT-20590452
[Presentation] Substrate recognition of collagen-binding domains derived from bacterial collagenases.2009
- Author(s)
  Matsushita O., Nishi N., Koide T., Philominathan S.T.L., Sakon J., Gensure R.C., Iwashiro H., Adachi E.
- Organizer
  8th Pan-pacific connective tissue societies symposium, 41st Annual meeting of the Japanese society of connective tissue research, 56th Annual meeting of the Japan matrix club
- Place of Presentation
  神奈川県逗子市
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-20590452
[Presentation] ガス壊疽菌群コラゲナーゼの基質認識機構と骨粗鬆症治療への応用2008
- Author(s)
  松下治
- Organizer
  第81回日本細菌学会総会
- Place of Presentation
  京都府京都市
- Year and Date
  2008-03-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590429
[Presentation] Collagen binding mechanism of a novel osteoporosis drug.2008
- Author(s)
  PST Leena, O Matsushita, R Gensure, J Sakon
- Organizer
  51st Annunal Meeting of Biophysical Society
- Place of Presentation
  Baltjmore,Maryland,USA
- Year and Date
  2008-03-05
- Data Source
  KAKENHI-PROJECT-18590429
[Presentation] Collagen binding mechanism of a novel osteoporosis drug2008
- Author(s)
  PST Leena, O Matsushita, R Ge nsure, J Sakon
- Organizer
  51st Annunal Meeting of Biophysical Society
- Place of Presentation
  Baltimore,Maryland,USA
- Year and Date
  2008-03-05
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590429
[Presentation] Vector construction for production and purification of clostridial collagenases. (in Japanese)2008
- Author(s)
  Y, Tanaka, E, Tamai, S, Miyata, A, Okabe, H, Hohchi, O, Matsushita
- Organizer
  81st Annual Meeting of Japanese Society for Bacteriology
- Place of Presentation
  Kyoto, Kyoto
- Year and Date
  2008-03-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590429
[Presentation] Substrate recognition mechanism of clostridial collagenases and its application to the treatment of osteoporosis. (in Japanese)2008
- Author(s)
  O, Matsushita
- Organizer
  81st Annual Meeting of Japanese Society for Bacteriology
- Place of Presentation
  Kyoto, Kyoto
- Year and Date
  2008-03-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590429
[Presentation] ガス壊疽菌群コラゲナーゼのセグメント2の構造解析2008
- Author(s)
  松下治
- Organizer
  第91回日本細菌学会関東支部総会
- Place of Presentation
  千葉県長生郡長塚町
- Year and Date
  2008-10-23
- Data Source
  KAKENHI-PROJECT-20590452
[Presentation] Collagen binding mechanism of a novel osteoporosis drug2008
- Author(s)
  PST, Leena, O, Matsushita, R, Gensure, J, Sakon
- Organizer
  51st Annunal Meeting of Biophysical Society
- Place of Presentation
  Baltimore, Maryland, USA
- Year and Date
  2008-03-05
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590429
[Presentation] A novel drug delivery system based on the substrate recognition mechanism of clostridial collagenases. (in Japanese)2008
- Author(s)
  O, Matsushita
- Organizer
  90th Annual Meeting of Kanto branch, Japanese Society for Bacteriology
- Place of Presentation
  Shinjuku, Tokyo
- Year and Date
  2008-10-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590429
[Presentation] クロストリジウム菌コラゲナーゼの産生と精製用のベクターの構築2008
- Author(s)
  田中裕章、玉井栄治、宮田茂、岡部昭延、芳地一、松下治
- Organizer
  第81回日本細菌学会総会
- Place of Presentation
  京都府京都市
- Year and Date
  2008-03-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590429
[Presentation] Weekly administration of a novel parathyroid hormone-Collagen-binding domain fusion protein increases bone mineral density by more than 15 percent in normal mouse.2007
- Author(s)
  T Ponnapakkam, O Matsushita, J Sakon, RC Censure
- Organizer
  The American Society for Bone and Mineral Research
- Place of Presentation
  Honolulu,Hawaii,USA
- Year and Date
  2007-09-19
- Data Source
  KAKENHI-PROJECT-18590429
[Presentation] Vibzlo alginolyticusのコラーゲン分解レギュロンの発現調節について2007
- Author(s)
  松下治、宮田茂、玉井栄治、岡部昭延
- Organizer
  第80回日本細菌学会総会
- Place of Presentation
  大阪府大阪市
- Year and Date
  2007-03-26
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590429
[Presentation] Expression regulation of collagenolytic regulon in Vibrio altinolyticus. (in Japanese)2007
- Author(s)
  O, Matsushita, S, Miyata, E, Tamai, A, Okabe
- Organizer
  80th Annual Meeting of Japanese Society for Bacteriology
- Place of Presentation
  Osaka, Osaka
- Year and Date
  2007-03-26
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590429
[Presentation] Weekly administration of a novel parathyroid hormone - Collagen-binding domain fusion protein increases bone mineral density by more than 15 percent in normal mouse2007
- Author(s)
  T Ponnapakkam, O Matsushita, J Sakon, RC Gensure
- Organizer
  The American Society for Bone and Mineral Research
- Place of Presentation
  Honolulu,Hawaii,USA
- Year and Date
  2007-09-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590429
[Presentation] ガス壊疽菌群コラゲナーゼの基質認識機構と薬物送達システムへの応用2007
- Author(s)
  松下治
- Organizer
  第90回日本細菌学会関東支部総会
- Place of Presentation
  東京都新宿区
- Year and Date
  2007-10-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590429
[Presentation] Weekly administration of a novel parathyroid hormone-Collagen-binding domain fusion protein increases bone mineral density by more than 15 percent in normal mouse2007
- Author(s)
  T, Ponnapakkam, O, Matsushita, J, Sakon, RC, Gensure
- Organizer
  The American Society for Bone and Mineral Research
- Place of Presentation
  Honolulu, Hawaii, USA
- Year and Date
  2007-09-17
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590429
[Presentation] Collagen binding characteristics of collagen-binding domain from Clostri dium histolyticum class I collagenase2007
- Author(s)
  J Sakon, PST Leena, O Matsushita
- Organizer
  The American Society for Bone and Mineral Research
- Place of Presentation
  Honolulu,Hawaii,USA
- Year and Date
  2007-09-17
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590429
[Presentation] Collagen binding charactehstics of collagen-binding dolmain from Clostridium histolvticum class I collagenase.2007
- Author(s)
  J Sakon, PST Leena, O Matsushita
- Organizer
  The American Society for Bone and Mineral Research
- Place of Presentation
  Honolulu,Hawau,USA
- Year and Date
  2007-09-17
- Data Source
  KAKENHI-PROJECT-18590429
[Presentation] Collagen binding characteristics of collagen-binding domain from Clostridium histolyticum class I collagenase2007
- Author(s)
  J, Sakon, PST, Leena, O, Matsushita
- Organizer
  The American Society for Bone and Mineral Research
- Place of Presentation
  Honolulu, Hawaii, USA
- Year and Date
  2007-09-17
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590429
[Presentation] Vibrio alginolyticusコラゲナーゼの性状と発現調節2006
- Author(s)
  松下治、谷口有紀、宮田茂、玉井栄治、田中裕章、岡部昭延
- Organizer
  第59回日本細菌学会中国、四国支部総会
- Place of Presentation
  山口県宇部市
- Year and Date
  2006-10-18
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590429
[Presentation] Characterization of Vibrio alginolyticus collagenase and its expression regulation. (in Japanese)2006
- Author(s)
  O, Matsushita, Y, Taniguchi, S, Miyata, E, Tamai, Y, Tanaka, A, Okabe
- Organizer
  59th Annual Meeting of Chugoku-Shikoku branch, Japanese Society for Bacteriology
- Place of Presentation
  Ube, Yamaguchi
- Year and Date
  2006-10-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590429
[Presentation] Acceleration of periosteal bone formation by human basic fibroblast growth factor containing a collagen-binding domain from Clostridium histolyticum collagenase
- Author(s)
  Uchida K, Matsushita O, Naruse K, Inoue G, Takaso M.
- Organizer
  World Congress on Controversies, Debates & Consensus in Bone, Muscle & Joint Diseases
- Place of Presentation
  Brussels
- Data Source
  KAKENHI-PROJECT-25670659
[Presentation] コラーゲン結合性線維芽細胞増殖因子（bFGF-CBD）とコラーゲンシートの併用による同種骨移植後の骨癒合促進
- Author(s)
  上野正喜、内田健太郎、斉藤　亘、余頃瑞希、井上玄、松下治、高平尚伸、高相晶士.
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  幕張
- Data Source
  KAKENHI-PROJECT-25670659
[Presentation] 脊椎手術におけるコラーゲン結合ドメインを融合した塩基性線維芽細胞増殖因子の骨形成に与える影響
- Author(s)
  井上玄、内田健太郎、上野正喜、斉藤亘、中澤俊之、井村貴之、松下治、高平尚伸、高相晶士.
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  幕張
- Data Source
  KAKENHI-PROJECT-25670659
[Presentation] Injectable コラーゲンパウダーとコラーゲン結合型線維芽細胞増殖因子による骨折後の骨形成促進効果の検討
- Author(s)
  斉藤　亘、内田健太郎、上野正喜、井上　玄、大貫裕子、松下治、高相晶士.
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  幕張
- Data Source
  KAKENHI-PROJECT-25670659
[Presentation] 線維芽細胞増殖因子アンカーリング間葉系細胞積層シートの骨形成能の検討
- Author(s)
  内田健太郎、堀川恭佑、井上玄、松下　治、斎藤亘、成瀬康治、藤巻寿子、占部憲、高相晶士.
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  城山観光ホテル（鹿児島県鹿児島市）
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-25670659
[Presentation] ガス壊疽菌コラゲナーゼの基質結合ドメインと再生医療への応用（第２報）
- Author(s)
  松下　治、美間健彦、山本由弥子、後藤和義、西　望、小出隆規、内田健太郎、高相晶士、他５名
- Organizer
  第61回トキシンシンポジウム
- Place of Presentation
  徳島県鳴門市
- Year and Date
  2014-09-03 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-26460527
[Presentation] Acceleration of bone formation during fracture healing by injectable collagen powder and human basic fibroblast growth factor containing a collagen-binding domain from Clostridium histolyticum collagenase
- Author(s)
  Saito W, Uchida K, Ueno M, Matsushita O, Inoue G, Nishi N, Ogura T, Hattori S, Fujimaki H, Tanaka K, Takaso M.
- Organizer
  APASTB/JSTT Combined Scientific Meeting 2014
- Place of Presentation
  長良川国際会議場（岐阜県岐阜市）
- Year and Date
  2014-08-27 – 2014-08-29
- Data Source
  KAKENHI-PROJECT-26293341
[Presentation] ボツリヌス毒素を利用した神経障害性疼痛治療
- Author(s)
  松香芳三，丸濱功太郎，山本由弥子，小熊惠二，松下治
- Organizer
  第88回日本細菌学会総会
- Place of Presentation
  岐阜
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26350499
[Presentation] 三叉神経におけるA型ボツリヌス神経毒素の局在と軸索輸送
- Author(s)
  山本由弥子，丸濱功太郎，松香芳三，美間健彦，後藤和義，横田憲治，松下治，小熊惠二
- Organizer
  第67回日本細菌学会中国・四国支部総会
- Place of Presentation
  徳島
- Year and Date
  2014-10-04 – 2014-10-05
- Data Source
  KAKENHI-PROJECT-26350499
[Presentation] Growth factor delivery based on substrate-binding domains derived from a clostridial collagenase.
- Author(s)
  松下　治、美間健彦、後藤和義、山本由弥子、横田憲治、内田健太郎
- Organizer
  第88回日本細菌学会総会
- Place of Presentation
  岐阜県岐阜市
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460527

1. OKABE Akinobu (20093677)

# of Collaborated Projects: 11 results

# of Collaborated Products: 1 results
2. MIYATA Shigeru (90314913)

# of Collaborated Projects: 8 results

# of Collaborated Products: 12 results
3. KATAYAMA Seiichi (70169473)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
4. UCHIDA Kentaro (50547578)

# of Collaborated Projects: 8 results

# of Collaborated Products: 27 results
5. MIMA Takehiko (80596437)

# of Collaborated Projects: 6 results

# of Collaborated Products: 13 results
6. MIMAMI Junzaburo (40157566)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
7. TAMAI Eiji (40333512)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
8. TOKUDA Masaaki (10163974)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
9. INOUE Gen (80594209)

# of Collaborated Projects: 4 results

# of Collaborated Products: 20 results
10. KOBAYASHI Ryoji (00020917)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
11. KOIDE Takaki (70322253)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
12. MABUCHI Yo (50424172)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
13. TAKASO Masashi (90439117)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
14. URABE Ken (90284489)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. ADACHI Eijiro (30110430)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
16. TOKUMITSU hiroshi (20237077)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. NARUSE Kouji (60276087)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. ITOMAN Moritoshi (70104528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. AKAIKE Toshihiro (30101207)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. TAGAWA Youichi (70262079)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. NISHIYAMA Toshio (60372455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. HATTORI Masakazu (40211479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. INOUE Jo (00433714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
24. MORI Nozomu (90124883)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
25. MIYASHITA Takenori (60363214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
26. Matsumoto Hiroshi (20423329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. KANEMASA Yasuhiro (80033059)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. FUJII Mari (40212485)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. KOTANI Nobuyuki (80231314)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. KUNITOMI Taiji (10033292)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. HIRAI Yoshikazu (00127581)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. SUGIMOTO Katsuyoshi (80322270)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. TAKEUCHI Yoshiki (20116619)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. NISHI Nozomu (10145047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. NARIYA Hirofumi (30452668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. YAMAMOTO YUMIKO (20403496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
37. Onuma Kenji (80348557)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 大鳥精司 (40361430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
39. 杉山成史 (80379776)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 山口文徳 (40271085)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. 松香芳三 (90243477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
42. 丸濱功太郎 (60712792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
43. 齋藤亘 (60439099)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
44. 宮城正行 (90627556)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
45. 高柴正悟 (50226768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
46. 平山晴子 (40635257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
47. 山本直史 (50432662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
48. 岡田裕之 (60263563)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
49. 後藤和義 (20626593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
50. 横田憲治 (00243460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
51. 田中健大 (70549857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
52. 笠原真悟 (90233692)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
53. 王英正 (50372579)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
54. OGUMA Keiji

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
55. SAKON Joshua

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

Matsushita Osamu 松下 治

MATSUSHITA Osamu 松下 治

Research Projects

Research Products

Co-Researchers

Development of periodontal tissue regeneration therapy for horizontal alveolar bone resorption with collagen-binding FGF-2Ongoing

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ピロリ菌除菌療法における腸内エコシステム破綻のメカニズムと制御Ongoing

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Elucidation of substrate recognition mechanism of bacterial collagenases to develop angiogenic drug seedsPrincipal InvestigatorOngoing

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腸管スキャフォールドとコラーゲン結合型成長因子を用いた拍動性グラフトの創成Ongoing

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注入型局所硬化ゲルを用いた幹細胞・成長因子送達による新規難治性骨折治療法の開発Ongoing

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高齢者脊椎固定術において確実な骨癒合を実現する機能性間葉系幹細胞シートの創生Ongoing

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Structure-function analysis of bacterial toxins in tissue destruction to apply their functional domains to regenerative medicinePrincipal Investigator

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Preclinical study to elucidate molecular mechanism of matrix anchoring using bacterial proteinsPrincipal Investigator

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Matsushita Osamu 松下治

MATSUSHITA Osamu 松下治