OKABE Akinobu 岡部昭延

Researcher Number	20093677
Other IDs
Affiliation *help	2014 : 中国学園大学, 公私立大学の部局等, 教授 2011 – 2014 : 中国学園大学, 現代生活学部, 教授 2009 – 2010 : Kagawa University, 医学部, 教授 2006 – 2007 : 香川大学, 医学部, 教授 2004 : Kagawa University, Molecular Microbiology, Professor, 医学部, 教授 … More
Review Section/Research Field	Principal Investigator Bacteriology (including Mycology) / Bacteriology (including Mycology) / 細菌学 / Bacteriology (including mycology) Except Principal Investigator Bacteriology (including Mycology) / Bacteriology (including Mycology) / Neurochemistry/Neuropharmacology / 細菌学 / Pathological medical chemistry
Keywords	Principal Investigator Clostridium perfringens / ウエルシュ菌 / ウェルシュ菌 / α毒素 / phospholipase C / 遺伝子発現 / ε毒素 / Bent DNA / Receptor / Clostridium … More Except Principal Investigator Clostridium perfringens / CaM kinase II / NMDA / LTP / phased A-tracts / 海馬 / calmodulin-dependent protein kinase II / brain / coli / パーフリンゲンス / 易熱性腸管毒素 / alcoholism / 細胞毒性 / ε毒素 / カルシウム結合蛋白質 / 糖鎖分解酵素 / epsilon-toxin / 細胞外マトリックス蛋白質 / calcineurin / ベントDNA / 36kDaMAGP / フォスフォリパーゼC(α毒素) / blood vessel / Perfringolysin / perfringens / 病原性 / phospholipase C / ε-毒素 / K.oxytoca / elasith / プラスミド / C / hippocampus / transcriptional regulation / K / ウエルシュ菌 / Ca^<2+> / マウス致死活性 / Ca^<2+> binding protein / microfibril / コンテロトキシン / トリプシン / アルコール依存症 / UPエレメント / ミクロフィブリル / 細胞付着性因子 / RNAポリメラーゼ / hypothermia / ウェルシュ菌 / hyaluronidase / 細胞毒素 / 転写調節 / lambda-toxin / 病原性大腸菌 / mouse lethality / カルシウムイオン / 病原性因子の遺伝子クローニング / ホスホリパーゼC / EF hand protein / クレブシラ・オキシトーカ / クレブシェラ / extracellular matrix protein / 組換え毒素 / Calbrain / クロストリディウム・パーフリンゲンス / 細菌病原性因子 / 染色体異常 / tox遺伝子 / クロストリジウム / oxytoca / NMR / 細胞接着 / 下痢原性大腸菌 / Cell adherence factor / inhibitor / オキシトーカ / ミクロフィブリン / Cytotoxin / Smith-Magenis syndrome / 脳 / Diarrheagenic E / Smith-Magenis症候群 / 低体温 / 発現系 / S100 / 36kDa MAGP / 細菌の細胞付着性 / trypsin / calbrain / RGD蛋白質 / エラスチン / 溶血毒(A毒素) / S-100 / λ-毒素 / 記憶 / gene cloning / RNA polymerase Less

バイオガス生産に向けたウェルシュ菌の遺伝子改変に関する研究Principal Investigator
- Principal Investigator
  
  岡部昭延
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Chugoku Gakuen University
Functional and pathogenic analysis of carbohydrate-active enzymes from Clostridium perfirngens
- Principal Investigator
  
  MIYATA Shigeru
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Chubu University
A mechanism for regulation of clostripain activity and modification of inflammatory response by the enzyme.Principal Investigator
- Principal Investigator
  
  OKABE Akinobu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Chugoku Gakuen University
  Kagawa University
A study on a mechanism for the transcriptional regulation of an epsilon-toxin gene by a novel type of bent DNAPrincipal Investigator
- Principal Investigator
  
  OKABE Akinobu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kagawa University
A study on the mechanism underlying the action of Clostridium perfringens alpha- and epsilon-toxins to membrane lipid raftsPrincipal Investigator
- Principal Investigator
  
  OKABE Akinobu
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  KAGAWA UNIVERSITY
  香川大学(医学部)
特殊ベント・プロモーターを利用した新規高発現ベクターの構築Principal Investigator
- Principal Investigator
  
  岡部昭延
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  香川大学(医学部)
Study on structure biology and molecular pathology of Clostridium perfringens epsilon-toxinPrincipal Investigator
- Principal Investigator
  
  OKABE akinobu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kagawa Medical University
水素ガス産生用ウエルシュ菌バイオリアクター開発のための基礎研究Principal Investigator
- Principal Investigator
  
  岡部昭延
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  香川医科大学
Studies on neurotropism of Clostridium perfringens epsilon-toxin and molecular mechanism of its toxicity toward neuronal cellsPrincipal Investigator
- Principal Investigator
  
  OKABE Akinobu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kagawa Medical University
Neuron specific calcium-binding Protein, calbrain, is involved in memory formation.
- Principal Investigator
  
  TOKUDA Masaaki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  KAGAWA MEDICAL UNIVERSITY
Function of promoter upstream bent DNA of the Clostridium perfringens phospholipase C gene
- Principal Investigator
  
  KATAYAMA Seiichi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kagawa Medical University
Pathobiological role of 36 kDa microfibril-associated glycoprotein in Smith-Magenis syndrome.
- Principal Investigator
  
  KOBAYASHI Ryoji
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kagawa Medical University
Analysis of the activation and mode of action of Clostridium perfringens ε-toxin
- Principal Investigator
  
  MATSUSHITA Osamu, 南純三朗
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kagawa Medical University
Study on function of phospholipase C gene binding protein from Clostridium perfringensPrincipal Investigator
- Principal Investigator
  
  OKABE Akinobu
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kagawa Medical University
Function of protein (s) which can bind to an alpha-toxin gene of Clostridium perfringensPrincipal Investigator
- Principal Investigator
  
  OKABE Akinobu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kagawa Medical School
Roles of the alpha-,theta-,and k-toxins in histotoxicity of Clostridium perfringensPrincipal Investigator
- Principal Investigator
  
  OKABE Akinobu
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  細菌学
- Research Institution
  Kagawa Medical School
Analysis of the Alpha-Toxin Gene of Clostridium PerfringensPrincipal Investigator
- Principal Investigator
  
  OKABE Akinobu
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  細菌学
- Research Institution
  Kagawa Medical School
Pathogenic factors of cell adherent Escherichia coli
- Principal Investigator
  
  HAYASHI Hideo
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  細菌学
- Research Institution
  Kagawa Medical School
Factors of Lactobacillus casei which inhibit plasmid replicationPrincipal Investigator
- Principal Investigator
  
  OKABE Akinobu
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  細菌学
- Research Institution
  Kagawa Medical School

All 2014 2012 2011 2010 2008 2007 2005 Other

All Journal Article Presentation Book

[Book] 最新細菌・カビ・酵母図鑑2007
- Author(s)
  岡部昭延
- Total Pages
  228
- Publisher
  技術情報協会
- Data Source
  KAKENHI-PROJECT-18590428
[Book] 最新細菌・カビ・酵母図鑑2007
- Author(s)
  岡部昭延
- Total Pages
  228
- Publisher
  技術情報協会
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590428
[Journal Article] X-ray structure of a novel endolysin encoded by episomal phage phiSM101 of Clostridium perfringens2014
- Author(s)
  Eiji Tamai, Hiromi Yoshida, Hiroshi Sekiya, Hirofumi Nariya, Shigeru Miyata, Akinobu Okabe, Tomomi Kuwahara, Jun Maki, and Shigehiro Kamitori
- Journal Title
  
  Molecular Microbiology
  
  Volume : 92 Pages : 326-337
- Data Source
  KAKENHI-PROJECT-24590538
[Journal Article] ウェルシュ菌の自己凝集性に関する研究2012
- Author(s)
  坂本知世、杉井美香、平田知之(担当教員岡部昭延)
- Journal Title
  
  平成23年度卒業研究中国学園大学現代生活学部人間栄養学科7期生
  
  Pages : 68-72
- Data Source
  KAKENHI-PROJECT-21590483
[Journal Article] Identification and characterization of a putative endolysin encoded by episomal phage phiSM101 of Clostridium perfringens2011
- Author(s)
  Hirofumi Nariya, Shigeru Miyata, Eiji Tamai, Hiroshi Sekiya, Jun Maki, and Akinobu Okabe
- Journal Title
  
  Applied Microbiology and Biotechnology
  
  Volume : 90-6 Pages : 1973-1979
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590483
[Journal Article] Development and characterization of a xylose-inducible gene expression system for Clostridium perfringens2011
- Author(s)
  Hirofumi Nariya, Shigeru Miyata, Tomomi Kuwahara, and Akinobu Okabe
- Journal Title
  
  Applied and Environmental Microbiology
  
  Volume : 77-23 Pages : 8439-8441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590483
[Journal Article] High-level production and purification of clostripain expressed in a virulence-attenuated strain of Clostridium perfringens2011
- Author(s)
  Hiroaki Tanaka, Hirofumi Nariya, Motoo Suzuki, Hitoshi Houchi, Eiji Tamai, Shigeru Miyata, and Akinobu Okabe
- Journal Title
  
  Protein Expression and Purification
  
  Volume : 76-1 Pages : 83-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590483
[Journal Article] Development and application of a method for counterselectable in-frame deletion in Clostridium perfringens2011
- Author(s)
  Hirofumi Nariya, Shigeru Miyata, Motoo Suzuki, Eiji Tamai, and Akinobu Okabe
- Journal Title
  
  Applied and Environmental Microbiology
  
  Volume : 77-4 Pages : 1375-1382
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590483
[Journal Article] Development and characterization of a xylose-inducible gene expression system for Clostridium perfringens2011
- Author(s)
  Hirofumi Nariya, Akinobu Okabe
- Journal Title
  
  Applied and Enviromental Microbiology
  
  Volume : 77 Pages : 8439-8441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590483
[Journal Article] Identification and characterization of a putative endolysin encoded by episomal phage phiSM101 of Clostridium perfringens2011
- Author(s)
  Hirofumi Nariya, Akinobu Okabe
- Journal Title
  
  Applied Microbiology and Biotechnology
  
  Volume : 90 Pages : 1973-1979
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590483
[Journal Article] Purification and characterization of a clostripain-like protease from a recombinant Clostridium perfringens culture2010
- Author(s)
  Sadao Manabe, Hirofumi Nariya, Shigeru Miyata, Hiroaki Tanaka, Junzaburo Minami, Motoo Suzuki, Yuki Taniguchi, and Akinobu Okabe
- Journal Title
  
  Microbiology
  
  Volume : 156-2 Pages : 561-569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590483
[Journal Article] ウェルシュ菌のClostripain-like proteaseの病原的意義についての研究2010
- Author(s)
  岡部昭延
- Journal Title
  
  乳酸菌研究会に関する報告書
  
  Pages : 300-303
- Data Source
  KAKENHI-PROJECT-21590483
[Journal Article] Purification and characterization of a clostripain-like protease from a recombinant Clostridium perfringens culture2010
- Author(s)
  Akinobu Okabe
- Journal Title
  
  Microbiology 156
  
  Pages : 561-569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590483
[Journal Article] Construction and characterization of a clostripain-like protease-deficient mutant of Clostridium perfringens as a strain for clostridial gene expression2008
- Author(s)
  Tanaka H, Tamai E, Miyata S, Taniguchi Y, Nariya H, Hatano N, Houchi H, Okabe A.
- Journal Title
  
  Applied Microbiology and Biotechnology 77
  
  Pages : 1063-1071
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590428
[Journal Article] ウエルシュ菌のプロテアーゼ・ノックアウト株の構築と利用について2007
- Author(s)
  岡部昭延, 田中裕章, 宮田茂, 玉井栄治
- Journal Title
  
  乳酸菌研究会に関する報告書 18年度版
  
  Pages : 437-443
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590428
[Journal Article] Construction of a clostripain-like protease mutant and its application2007
- Author(s)
  Okabe, A., Tanaka, H., Miyata, S., Tamai, E
- Journal Title
  
  Annual Report of Studies on Lactic Acid Bacteria
  
  Pages : 437-443
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590428
[Journal Article] Changens in ganglioside content affect the binding of Clostridium perfringens epsilon-toxin to detergent-resistant membranes of Madin-Darby canine kidney cells.2005
- Author(s)
  Shimamoto S, Tamai E, Matsushita O, Minami J, Okabe A, Miyata S.
- Journal Title
  
  Microbiology and Immunology 49(3)
  
  Pages : 245-253
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390144
[Journal Article] Construction and characterization of a clostripain-like protease-deficient mutant of Clostridium perfringens as a strain for clostridial gene expression
- Author(s)
  Tanaka, H., Tamai, E., Miyata, S., Taniguchi, Y., Nariya, H., Hatano, N., Houchi H, Okabe, A
- Journal Title
  
  Applied Microbiology and Biotechnology 77(5)
  
  Pages : 1063-1071
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590428
[Presentation] Development and characterization of a xylose-inducible gene expression system for Clostridium perfringens2011
- Author(s)
  Hirofumi Nariya, Shigeru Miyata, and Akinobu Okabe
- Organizer
  XIII International Congress of Bacteriology and Applied Microbiology, International Union of Microbiological Societies Congresses 2011
- Place of Presentation
  Sapporo, Japan
- Data Source
  KAKENHI-PROJECT-21590483
[Presentation] High-level production and purification of clostripain expressed in a virulence-attenuated strain of Clostridium perfringens2011
- Author(s)
  Hiroaki Tanaka, Hirofumi Nariya, Motoo Suzuki, Shigeru Miyata, Eiji Tamai, Shinji Kosaka, Noriyasu Fukuoka, Hitoshi Houchi, and Akinobu Okabe
- Organizer
  XIII International Congress of Bacteriology and Applied Microbiology, International Union of Microbiological Societies Congresses 2011
- Place of Presentation
  Sapporo, Japan
- Data Source
  KAKENHI-PROJECT-21590483
[Presentation] Clostridium perfringensの菌体表面のglyceraldehyde-3-phosphate dehydro-genaseの研究2011
- Author(s)
  岡部昭延、宮田茂、成谷宏文
- Organizer
  全国乳酸菌研究会中国四国支部会
- Place of Presentation
  岡山ホテルグランヴィア
- Year and Date
  2011-06-17
- Data Source
  KAKENHI-PROJECT-21590483
[Presentation] ウェルシュ菌のglyceraldehyde-3-phosphate dehydrogenaseの性状解析2010
- Author(s)
  田中裕章, 成谷宏文, 鈴木基生, 谷口有紀, 芳地一, 宮田茂, 岡部昭延
- Organizer
  第63回日本細菌学会中国・四国支部総会
- Place of Presentation
  松山
- Year and Date
  2010-10-16
- Data Source
  KAKENHI-PROJECT-21590483
[Presentation] Clostridium 属のクロストリパインの量産と精製および性状解析について2010
- Author(s)
  岡部昭延
- Organizer
  第82回日本細菌学会総会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2010-03-27
- Data Source
  KAKENHI-PROJECT-21590483

1. MATSUSHITA Osamu (00209537)

# of Collaborated Projects : 12results

# of Collaborated Products : 1results
2. KATAYAMA Sei-ichi (70169473)

# of Collaborated Projects : 8results

# of Collaborated Products : 0results
3. MIYATA Shigeru (90314913)

# of Collaborated Projects : 8results

# of Collaborated Products : 15results
4. MINAMI Junzaburo (40157566)

# of Collaborated Projects : 7results

# of Collaborated Products : 0results
5. KOBAYASHI Ryoji (00020917)

# of Collaborated Projects : 5results

# of Collaborated Products : 0results
6. TOKUDA Masaaki (10163974)

# of Collaborated Projects : 4results

# of Collaborated Products : 0results
7. TAMAI Eiji (40333512)

# of Collaborated Projects : 3results

# of Collaborated Products : 5results
8. NARIYA Hirofumi (30452668)

# of Collaborated Projects : 3results

# of Collaborated Products : 14results
9. TOKUMITSU hiroshi (20237077)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
10. HAYASHI Hideo (40033203)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
11. SUZUKI Motoo (80457340)

# of Collaborated Projects : 1results

# of Collaborated Products : 5results
12. MORIYAMA Ryuichi (60191061)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. YOSHIDA Hiromi (10313305)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
14. NAKAKITA Shinichi (40314356)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
15. SATO Chubun (20032815)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
16. SUGANUMA Tatsuo (60115350)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
17. MAETA Hajime (00075508)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
18. SUGIMOTO Katsuyoshi (80322270)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
19. TAKEUCHI Yoshiki (20116619)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
20. ITANO Toshifumi (60145042)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
21. 山口文徳 (40271085)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

OKABE Akinobu 岡部 昭延

Research Projects

Research Products

Co-Researchers

バイオガス生産に向けたウェルシュ菌の遺伝子改変に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional and pathogenic analysis of carbohydrate-active enzymes from Clostridium perfirngens

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A mechanism for regulation of clostripain activity and modification of inflammatory response by the enzyme.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study on a mechanism for the transcriptional regulation of an epsilon-toxin gene by a novel type of bent DNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study on the mechanism underlying the action of Clostridium perfringens alpha- and epsilon-toxins to membrane lipid raftsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

特殊ベント・プロモーターを利用した新規高発現ベクターの構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on structure biology and molecular pathology of Clostridium perfringens epsilon-toxinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

水素ガス産生用ウエルシュ菌バイオリアクター開発のための基礎研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on neurotropism of Clostridium perfringens epsilon-toxin and molecular mechanism of its toxicity toward neuronal cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Neuron specific calcium-binding Protein, calbrain, is involved in memory formation.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Function of promoter upstream bent DNA of the Clostridium perfringens phospholipase C gene

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathobiological role of 36 kDa microfibril-associated glycoprotein in Smith-Magenis syndrome.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the activation and mode of action of Clostridium perfringens ε-toxin

Principal Investigator

Project Period (FY)

Research Category

OKABE Akinobu 岡部昭延