Ideguchi Hidetaka 井手口英隆

… Alternative Names

井手口英隆イデグチヒデタカ

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Researcher Number	80779421
Other IDs
Affiliation (Current)	2023: 岡山大学, 歯学部, 博士研究員
Affiliation (based on the past Project Information) *help	2021 – 2022: 岡山大学, 医歯薬学域, 助教 2020: 岡山大学, 医歯薬学総合研究科, 助教 2016 – 2017: 岡山大学, 医歯薬学総合研究科, 助教
Review Section/Research Field	Principal Investigator Periodontology / 0907:Oral science and related fields / Basic Section 57020:Oral pathobiological science-related Except Principal Investigator Periodontology / Basic Section 57030:Conservative dentistry-related
Keywords	Principal Investigator 歯周炎 / HMGB1 / Th17細胞 / 歯周病 / 分子標的薬 / ドラッグデリバリーシステム / HighMobilityGroupBox 1 / 分子イメージング / HighMobilityGroupBox1 / ナノDDS … More / 抗炎症作用 / 歯周病治療薬 / 歯学 / 歯周病治療 / 炎症性疾患 / M1マクロファージ / マクロファージ / T細胞 / 補体経路 … More Except Principal Investigator 炎症 / 歯周病 / サイトカイン / HMGB1 / マクロファージ / 歯肉上皮細胞 / 好中球 / 歯周炎 / 炎症性サイトカイン / 抗体療法 / 歯学 / 免疫学 / 遺伝子 / 細胞外小胞 / 侵襲性歯周炎 / マイクロRNA / プロテオーム Less

補体とTh17細胞のクロストークから導く歯周病態の解明と新規治療コンセプトの検討Principal Investigator
- Principal Investigator
  
  井手口英隆
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Okayama University
細胞外小胞の口腔トロピズムを基軸とする侵襲性歯周炎の病態解明と診断への応用展開
- Principal Investigator
  
  山本直史
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Okayama University
HMGB1が歯周病に及ぼす免疫学的影響の解明とその制御による新規歯周病治療の検討Principal Investigator
- Principal Investigator
  
  井手口英隆
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0907:Oral science and related fields
- Research Institution
  Okayama University
Control of periodontal inflammation by anti-inflammatory molecular targeting drug applied with nano drug delivery systemPrincipal Investigator
- Principal Investigator
  
  Ideguchi Hidetaka
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Periodontology
- Research Institution
  Okayama University
Functional analysis of HMGB1 as an inflammatory mediator in periodontitis
- Principal Investigator
  
  YAMASHIRO KEISUKE
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Periodontology
- Research Institution
  Okayama University

All 2021 2020 2018 2017 2016

All Journal Article Presentation

[Journal Article] High Mobility Group Box 1 Expression in Oral Inflammation and Regeneration2020
- Author(s)
  Keisuke Yamashiro, Hidetaka Ideguchi, Hiroaki Aoyagi, Chiaki Yoshihara-Hirata, Anna Hirai, Risa Suzuki-Kyoshima, Yao Zhang, Hidenori Wake, Masahiro Nishibori, Tadashi Yamamoto, ShogoTakashiba
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 11 Pages: 1461-1461
- DOI
  10.3389/fimmu.2020.01461
- NAID
  120006880201
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10128, KAKENHI-PROJECT-20K23054
[Journal Article] HMGB1-induced inflammatory response promotes bone healing in murine tooth extraction socket.2018
- Author(s)
  Aoyagi Hiroaki、Yamashiro Keisuke、Hirata-Yoshihara Chiaki、Ideguchi Hidetaka、Yamasaki Mutsuyo、Kawamura Mari、Yamamoto Tadashi、Kochi Shinsuke、Wake Hidenori、Nishibori Masahiro、Takashiba Shogo
- Journal Title
  
  Journal of Cellular Biochemistry
  
  Volume: - Pages: 5481-5490
- DOI
  10.1002/jcb.26710
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06994, KAKENHI-PROJECT-16K20670, KAKENHI-PROJECT-18K17050
[Journal Article] Anti-HMGB1 neutralizing antibody attenuates periodontal inflammation and bone resorption in a murine periodontitis model.2018
- Author(s)
  Yoshihara-Hirata Chiaki、Yamashiro Keisuke、Yamamoto Tadashi、Aoyagi Hiroaki、Ideguchi Hidetaka、Kawamura Mari、Suzuki Risa、Ono Mitsuaki、Wake Hidenori、Nishibori Masahiro、Takashiba Shogo
- Journal Title
  
  Infect Immun.
  
  Volume: 86
- DOI
  10.1128/iai.00111-18
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06994, KAKENHI-PROJECT-16K20670, KAKENHI-PROJECT-18K17050, KAKENHI-PROJECT-16K11624
[Journal Article] Modulation of microenvironment for controlling the fate of periodontal ligament cells: the role of Rho/ROCK signaling and cytoskeletal dynamics2017
- Author(s)
  Yamamoto Tadashi、Ugawa Yuki、Kawamura Mari、Yamashiro Keisuke、Kochi Shinsuke、Ideguchi Hidetaka、Takashiba Shogo
- Journal Title
  
  Journal of Cell Communication and Signaling
  
  Volume: 12 Pages: 369-378
- DOI
  10.1007/s12079-017-0425-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06994
[Journal Article] Aggregatibacter actinomycetemcomitans regulates the expression of integrins and reduces cell adhesion via integrin α5 in human gingival epithelial cells2017
- Author(s)
  Kochi Shinsuke、Yamashiro Keisuke、Hongo Shoichi、Yamamoto Tadashi、Ugawa Yuki、Shimoe Masayuki、Kawamura Mari、Hirata-Yoshihara Chiaki、Ideguchi Hidetaka、Maeda Hiroshi、Takashiba Shogo
- Journal Title
  
  Molecular and Cellular Biochemistry
  
  Volume: 436 Pages: 39-48
- DOI
  10.1007/s11010-017-3076-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06994
[Presentation] 侵襲性歯周炎の血液診断マーカー候補となる細胞外小胞由来マイクロRNAとその炎症誘導機構．2021
- Author(s)
  森彩乃，山本直史，井手口英隆，河村麻理，河本美奈，伊東昌洋，小野喜章，中山真彰，山城圭介，大森一弘，高柴正悟．
- Organizer
  第42回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-21H03119
[Presentation] HMGB1 Promotes Periodontitis by Regulating Macrophage to M1 Polarization2020
- Author(s)
  A. HIRAI, H. IDEGUCHI, K. YAMASHIRO, Z. YAO, C. YOSHIHARA-HIRATA, H. AOYAGI, T. YAMAMOTO, M. NISHIBORI ，S. TAKASHIBA
- Organizer
  第64回秋季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-20K23054
[Presentation] High Mobility Group Box 1（HMGB1）はマクロファージからのCCL2分泌を制御して抜歯窩の歯周組織再生を促進する2020
- Author(s)
  井手口英隆，平井杏奈，山城圭介，京嶌里沙，青柳浩明，山本直史，高柴正悟
- Organizer
  第63回秋季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-20K23054
[Presentation] 炎症性メディエーターHMGB1が歯槽骨治癒における血管新生の遺伝子発現を促進する2017
- Author(s)
  青柳浩明，山城圭介，吉原千暁，井手口英隆，山本直史，河村麻理，下江正幸，本郷昌一，劉克約，西堀正洋，高柴正悟
- Organizer
  第38回炎症再生医学会
- Data Source
  KAKENHI-PROJECT-16K20670
[Presentation] HMGB1が歯槽骨治癒に及ぼす影響2017
- Author(s)
  青柳浩明, 山城圭介, 井手口英隆, 平田千暁, 下江正幸, 河村麻理, 山本直史, 高柴正悟
- Organizer
  日本歯周病学会
- Data Source
  KAKENHI-PROJECT-16H06994
[Presentation] HMGB1が歯槽骨治癒に及ぼす影響2017
- Author(s)
  青柳浩明，山城圭介，吉原千暁，井手口英隆，山本直史，河村麻理，下江正幸，高柴正悟
- Organizer
  第60回日本歯周病学会
- Data Source
  KAKENHI-PROJECT-16K20670
[Presentation] 炎症性メディエーターHMGB1が歯槽骨治癒における血管新生の遺伝子発現を促進する2017
- Author(s)
  青柳浩明, 山城圭介, 井手口英隆, 平田千暁, 河村麻理, ,山崎睦代, 山本直史, 和氣秀徳, 西堀正洋, 高柴正悟
- Organizer
  日本炎症再生医学会
- Data Source
  KAKENHI-PROJECT-16H06994
[Presentation] 炎症マーカーを標的とした分子イメージングによる歯周組織の新規検査法の確立に向けた臨床的／基礎的研究2016
- Author(s)
  井手口英隆、山城圭介、山本直史、下江正幸、高柴正悟
- Organizer
  第9回日本口腔検査学会学術大会
- Place of Presentation
  奥羽大学（福島県・郡山市）
- Year and Date
  2016-10-01
- Data Source
  KAKENHI-PROJECT-16H06994
[Presentation] Anti-HMGB1 neutralizing antibody attenuates cytokine secretion and progression of periodontitis2016
- Author(s)
  C. YOSHIHARA，K. YAMASHIRO，T. YAMAMOTO，H. IDEGUCHI，H. AOYAGI，M. SHIMOE，S. HONGO，M. KAWAMURA，K. Liu，M. NISHIBORI，S. TAKASHIBA，
- Organizer
  IADR/APR General Session & Exhibition
- Place of Presentation
  COEX Convention Center, Korea, Seoul
- Year and Date
  2016-06-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20670
[Presentation] 実験的歯周炎モデルマウスにおける抗HMGB1抗体の歯周炎抑制効果2016
- Author(s)
  吉原千暁，山城圭介，山本直史，井手口英隆，青柳浩明，下江正幸，本郷昌一，河村麻理，高柴正悟
- Organizer
  第59回春季日本歯周病学会
- Place of Presentation
  かごしま県民交流センター，鹿児島市
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PROJECT-16K20670

1. YAMAMOTO Tadashi (50432662)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. TAKASHIBA Shogo (50226768)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. YAMASHIRO KEISUKE (30581087)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
4. AOYAGI Hiroaki (10814501)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
5. KOCHI Shinsuke (70803138)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. WAKE Hidenori (60570520)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. NISHIBORI Masahiro (50135943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. 江口傑徳 (20457229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 宮地孝明 (40550314)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 江國大輔 (70346443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KIMURA Aya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 大野充昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ideguchi Hidetaka 井手口 英隆

井手口 英隆 イデグチ ヒデタカ

Research Projects

Research Products

Co-Researchers

補体とTh17細胞のクロストークから導く歯周病態の解明と新規治療コンセプトの検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細胞外小胞の口腔トロピズムを基軸とする侵襲性歯周炎の病態解明と診断への応用展開

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

HMGB1が歯周病に及ぼす免疫学的影響の解明とその制御による新規歯周病治療の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Control of periodontal inflammation by anti-inflammatory molecular targeting drug applied with nano drug delivery systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of HMGB1 as an inflammatory mediator in periodontitis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] High Mobility Group Box 1 Expression in Oral Inflammation and Regeneration2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] HMGB1-induced inflammatory response promotes bone healing in murine tooth extraction socket.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-HMGB1 neutralizing antibody attenuates periodontal inflammation and bone resorption in a murine periodontitis model.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Modulation of microenvironment for controlling the fate of periodontal ligament cells: the role of Rho/ROCK signaling and cytoskeletal dynamics2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aggregatibacter actinomycetemcomitans regulates the expression of integrins and reduces cell adhesion via integrin α5 in human gingival epithelial cells2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] 侵襲性歯周炎の血液診断マーカー候補となる細胞外小胞由来マイクロRNAとその炎症誘導機構．2021

Author(s)

Organizer

Data Source

[Presentation] HMGB1 Promotes Periodontitis by Regulating Macrophage to M1 Polarization2020

Author(s)

Organizer

Data Source

[Presentation] High Mobility Group Box 1（HMGB1）は マクロファージからのCCL2分泌を制御して抜歯窩の歯周組織再生を促進する2020

Author(s)

Organizer

Data Source

[Presentation] 炎症性メディエーターHMGB1が歯槽骨治癒における血管新生の遺伝子発現を促進する2017

Author(s)

Organizer

Data Source

[Presentation] HMGB1が歯槽骨治癒に及ぼす影響2017

Author(s)

Organizer

Ideguchi Hidetaka 井手口英隆

井手口英隆イデグチヒデタカ

[Presentation] High Mobility Group Box 1（HMGB1）はマクロファージからのCCL2分泌を制御して抜歯窩の歯周組織再生を促進する2020

[Presentation] 炎症性メディエーターHMGB1が歯槽骨治癒における血管新生の遺伝子発現を促進する2017