MATSUBARA Hirochika 松原寛知

… Alternative Names

HIROCHIKA Matsubar 松原寛知

松原寛知マツバラヒロチカ

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Researcher Number	00374166
Other IDs
Affiliation (Current)	2025: 山梨大学, 大学院総合研究部, 准教授
Affiliation (based on the past Project Information) *help	2017: 山梨大学, 医学部, 講師 2013: 山梨大学, 医学部, 講師 2011: 山梨大学, 医学部・附属病院, 助教 2010: 山梨大学, 医学部・附属病院, 助手 2008: University of Yamanashi, 医学部・附属病院, 助教 … More 2007 – 2008: University of Yamanashi, 医学部附属病院, 助教 2007: University of Yamanashi, Faculty of Medicine, Assistant Professor 2006: 山梨大学, 医学部附属病院, 助手 2004: 山梨大学, 医学部附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Thoracic surgery Except Principal Investigator Human pathology / General surgery
Keywords	Principal Investigator 肺癌 / 肺癌の分子標的治療 / siRNA / mTOR / 原発性肺癌 / Na-Pheophorbide a / 光線力学療法 Except Principal Investigator Akt / 遺伝子増幅 / 肺癌 … More / 骨軟部肉腫 / EGFR / c-Myc / autocrine motility factor / microRNA / 遺伝子多型 / Pirh2 / シグナル伝達 / 骨軟部腫瘍 / mTOR / 遺伝子変異 / ubiquitin ligase / 細胞周期制御因子 / Ubiquitin ligase / MLPA / p27 / gastric carcinomas / bone and soft tissue sarcomas / lung carcinomas / gene amplification / HER-2 / Topoisomerase IIα / autocrine motihty factor / 胃癌 / microarray / AKT / メビオールジェル / 人工血管 / 分子標的療法 / リンパ節転移 / ポリソミー / S6 kinase / 縦隔 / 呼吸器 Less

Involvement of Akt/mTOR in lung cancer and design of novel therapy targeting them
- Principal Investigator
  
  DOBASHI Yoh
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Jichi Medical University
Aberrant activations of cellular kinases and exploration of novel targeted therapy in human solid cancers
- Principal Investigator
  
  DOBASHI Yoh
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Jichi Medical University
Development of artificial vessels by Mebiolgel and nanosheets prepared by laser supersonic multi-drawing
- Principal Investigator
  
  SHINDO Shunya
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  University of Yamanashi
Activation of signal transduction pathway by aberration of oncogenes : comprehensive analysis and application for multi-molecular targeting therapy
- Principal Investigator
  
  DOBASHI Yoh
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Jichi Medical University
Molecular targeting therapy as novel non-small cell lung carcinoma treatment(siRNA(mTOR))Principal Investigator
- Principal Investigator
  
  HIROCHIKA Matsubar
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  University of Yamanashi
Aberrant activation of signal transduction pathways regulating cell proliieration in human slid tumors. Molecular-pathological analysis and clinical application of molecular targeting therapy.
- Principal Investigator
  
  DOBASHI Yoh
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Jichi Medical University
光感受性物質フェオフォーバイドaを用いた光線力学療法の動物実験研究Principal Investigator
- Principal Investigator
  
  松原寛知
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Thoracic surgery
- Research Institution
  University of Yamanashi

All 2017 2016 2015 2012 2011 2010 2009 2008 2007 2006 2004

All Journal Article Presentation

[Journal Article] Loss of YAP1 defines neuroendocrine differentiation of lung tumors.2016
- Author(s)
  Ito T, Matsubara D, Tanaka I, Makiya K, Tanei ZI, Kumagai Y, Shiu SJ, Nakaoka HJ, Ishikawa S, Isagawa T, Morikawa T, Shinozaki-Ushiku A, Goto Y, Nakano T, Tsuchiya T, Tsubochi H, Komura D, Aburatani H, Dobashi Y, Nakajima J, Endo S, Fukayama M, Sekido Y, Niki T, Murakami Y.
- Journal Title
  
  Cancer Science
  
  Volume: 107 Issue: 10 Pages: 1527-1538
- DOI
  10.1111/cas.13013
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293080, KAKENHI-PROJECT-25460432, KAKENHI-PROJECT-16K08672, KAKENHI-PROJECT-26460438
[Journal Article] Diverse involvement of isoforms and gene aberrations of Akt in human lung carcinomas2015
- Author(s)
  Dobashi Y, Tsubochi H, Matsubara H, Inoue J, Inazawa J, Endo S, Ooi A
- Journal Title
  
  Cancer Sci
  
  Volume: - Issue: 6 Pages: 772-781
- DOI
  10.1111/cas.12669
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22134002, KAKENHI-PROJECT-25250019, KAKENHI-PROJECT-15K10270, KAKENHI-PROJECT-26460438, KAKENHI-PLANNED-15H05908, KAKENHI-PROJECT-25460452
[Journal Article] Non-small cell lung carcinoma therapy using mTOR-siRNA2012
- Author(s)
  Matsubara, H., Sakakibara, K., Kunimitsu, K., Matsuoka, H., Kato, K., Oyachi, N., Dobashi, Y., Matsumoto, M.
- Journal Title
  
  Int J Clin Exp Pathol
  
  Volume: 5(2) Pages: 119-125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590409
[Journal Article] Non-small cell lung carcinoma therapy using mTOR-siRNA.2012
- Author(s)
  Matsubara, H., Sakakibara, K., Kunimitsu, K., Matsuoka, H., Kato, K., Oyachi, N., Dobashi, Y., Matsumoto, M.
- Journal Title
  
  Int J Clin Exp Pathol.
  
  Volume: 5(2) Pages: 119-125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590409
[Journal Article] Genomic copy-number alterations of MYC and FHIT genes are associated with survival in esophageal squamous-cell carcinoma2012
- Author(s)
  Miyawaki Y, Kawachi H, Ooi A, Eishi Y, Kawano T, Inazawa J, Imoto I
- Journal Title
  
  Cancer Sci
  
  Volume: 103 Issue: 12 Pages: 1558-66
- DOI
  10.1016/j.humpath.2012.03.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240090, KAKENHI-PROJECT-22590310, KAKENHI-PROJECT-23590409, KAKENHI-PLANNED-22134002
[Journal Article] Molecular alterations in AKT and its protein activation in human lung carcinomas2012
- Author(s)
  Dobashi, Y., Kimura, M., Matsubara, H., Endo, S., Inazawa, J., Ooi, A.
- Journal Title
  
  Human Pathol
  
  Volume: 43(12) Pages: 2229-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590409
[Journal Article] Paradigm of kinase-driven pathway downstream of EGFR/Akt in human lung carcinomas2011
- Author(s)
  Dobashi, Y., Suzuki, S., Kimura, M., Matsubara, H., Tsubochi, H., Imoto, I.,Ooi, A.
- Journal Title
  
  Hum. Pathol
  
  Volume: 42(2) Pages: 214-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590409
[Journal Article] Paradigm of kinase-driven pathway downstream of EGFR/Akt in human lung carcinomas.2011
- Author(s)
  Dobashi, Y., Suzuki, S., Kimura, M., Matsubara, H., Tsubochi, H., Imoto, I., Ooi, A.
- Journal Title
  
  Hum. Pathol. 42(2)
  
  Pages: 214-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590351
[Journal Article] Critical and diverse involvement of the Akt/mTOR signaling in human lung carcinomas.2009
- Author(s)
  Dobashi, Y., Suzuki, S., Matsubara, H., Kimura, M., Endo, S., Ooi, A.
- Journal Title
  
  Cancer 115(1)
  
  Pages: 107-118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590351
[Journal Article] Recurrent mediastinal liposarcoma twenty years after the itialoperation:case report2007
- Author(s)
  Matsubara, H.
- Journal Title
  
  Ann Thorac Cardiovasc Surg 13(6)
  
  Pages: 407-409
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590327
[Journal Article] Recurrent mediastinal liposarcoma twenty years after the initial operation:case report2007
- Author(s)
  Matsubara, H.
- Journal Title
  
  Ann Thorac Cardiovasc Surg 13(6)
  
  Pages: 407-409
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590327
[Journal Article] Recurrent mediastinal liposarcoma twenty years after the initial operation : case report2007
- Author(s)
  Matsubara, H
- Journal Title
  
  Ann Thorac Cardiovasc Surg 13(6)
  
  Pages: 407-409
- NAID
  10024306695
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590327
[Journal Article] 再発胸腺癌に対してカルボプラチン+パクリタキセル併用化学療法が奏功した1例2006
- Author(s)
  松原寛知
- Journal Title
  
  山梨肺癌研究会会誌 19(4)
  
  Pages: 35-39
- Data Source
  KAKENHI-PROJECT-18590327
[Journal Article] 術前診断に難渋した乳癌肺転移の1例2006
- Author(s)
  松原寛知
- Journal Title
  
  山梨医学 34(10)
  
  Pages: 59-62
- Data Source
  KAKENHI-PROJECT-18590327
[Journal Article] ヒト肺癌転移リンパ節に対する研究用動物モデルの作製2004
- Author(s)
  水谷栄基, 井上秀範, 松原寛知他
- Journal Title
  
  肺癌 44
  
  Pages: 767-771
- NAID
  110003141149
- Data Source
  KAKENHI-PROJECT-16659366
[Presentation] 肺癌でAKT 遺伝子増幅に伴い変動するmicroRNA とそのターゲット2017
- Author(s)
  土橋洋、後藤明輝、松原大祐、椙村春彦、大井章史
- Organizer
  第106回日本病理学会総会
- Place of Presentation
  東京
- Year and Date
  2017-04-27
- Data Source
  KAKENHI-PROJECT-26460438
[Presentation] 肺癌におけるYAP1欠如と神経内分泌分化について2015
- Author(s)
  松原大祐、伊東剛、田中一大、石川俊平、後藤悌、中野智之、土橋洋、中島淳、遠藤俊輔、深山正久、関戸好孝、仁木利郎、村上善則.
- Organizer
  第74回日本癌学会総会
- Place of Presentation
  名古屋名古屋
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-26460438
[Presentation] CO2レーザー超音速マルチ延伸法で作製したPLLAナノファイバーシートでの細胞培養II2010
- Author(s)
  吉岡祐樹、榊原賢士、松原寛知、進藤俊哉、松本雅彦、窪田健司、鈴木章泰
- Organizer
  第19回ポリマー材料フォーラム
- Place of Presentation
  東京
- Year and Date
  2010-12-03
- Data Source
  KAKENHI-PROJECT-21591632
[Presentation] メビオールジェルを用いた血管平滑筋細胞の3次元培養の試み2009
- Author(s)
  榊原賢士、進藤俊哉、蓮田憲夫、松原寛知、加賀重亜喜、井上秀範、緒方孝治、鈴木章司、松本雅彦、窪田健司
- Organizer
  山梨医学会
- Place of Presentation
  甲府
- Year and Date
  2009-03-09
- Data Source
  KAKENHI-PROJECT-21591632
[Presentation] RNA干渉を用いたmTORの抑制による非小細胞肺癌細胞の細胞成長阻害の検討2008
- Author(s)
  松原寛知
- Organizer
  日本外科学会
- Place of Presentation
  長崎
- Year and Date
  2008-05-15
- Data Source
  KAKENHI-PROJECT-19790966
[Presentation] RNA干渉を用いたmTORの抑制による非小細胞肺癌細胞の細胞成長の阻害の研究2008
- Author(s)
  松原寛知
- Organizer
  日本外科学会
- Place of Presentation
  長崎
- Year and Date
  2008-05-15
- Data Source
  KAKENHI-PROJECT-19790966

1. DOBASHI Yoh (90231456)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
2. YANAGAWA Takashi (50294971)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. OOI Akishi (50160411)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
4. ENDO Syunsuke (10245037)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. HARUHIKO Sugimura (00196742)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. YANAGAWA Takashi (40400725)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. SATO Eiiti (80293455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SHINDO Shunya (50206322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. SAKAKIBARA Kenji (40419338)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. WATANABE Hideomi (40231724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 井上秀範 (80377556)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 坪地宏嘉 (50406055)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 後藤明輝 (90317090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. MATSYBARA Daisuk

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 仁木利郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 井上純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 稲澤譲治

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 橘逸勢

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MATSUBARA Hirochika 松原 寛知

HIROCHIKA Matsubar 松原 寛知

松原 寛知 マツバラ ヒロチカ

Research Projects

Research Products

Co-Researchers

Involvement of Akt/mTOR in lung cancer and design of novel therapy targeting them

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Aberrant activations of cellular kinases and exploration of novel targeted therapy in human solid cancers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of artificial vessels by Mebiolgel and nanosheets prepared by laser supersonic multi-drawing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Activation of signal transduction pathway by aberration of oncogenes : comprehensive analysis and application for multi-molecular targeting therapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular targeting therapy as novel non-small cell lung carcinoma treatment(siRNA(mTOR))Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Aberrant activation of signal transduction pathways regulating cell proliieration in human slid tumors. Molecular-pathological analysis and clinical application of molecular targeting therapy.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

光感受性物質フェオフォーバイドaを用いた光線力学療法の動物実験研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Loss of YAP1 defines neuroendocrine differentiation of lung tumors.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Diverse involvement of isoforms and gene aberrations of Akt in human lung carcinomas2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Non-small cell lung carcinoma therapy using mTOR-siRNA2012

Author(s)

Journal Title

Data Source

[Journal Article] Non-small cell lung carcinoma therapy using mTOR-siRNA.2012

Author(s)

Journal Title

Data Source

[Journal Article] Genomic copy-number alterations of MYC and FHIT genes are associated with survival in esophageal squamous-cell carcinoma2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular alterations in AKT and its protein activation in human lung carcinomas2012

Author(s)

Journal Title

Data Source

[Journal Article] Paradigm of kinase-driven pathway downstream of EGFR/Akt in human lung carcinomas2011

Author(s)

Journal Title

Data Source

[Journal Article] Paradigm of kinase-driven pathway downstream of EGFR/Akt in human lung carcinomas.2011

MATSUBARA Hirochika 松原寛知

HIROCHIKA Matsubar 松原寛知

松原寛知マツバラヒロチカ