Izumi Hironori 和泉宏謙

Researcher Number	00377342
Other IDs
Affiliation (Current)	2025: 富山大学, 医学部, 技術専門職員
Affiliation (based on the past Project Information) *help	2019 – 2024: 富山大学, 医学部, 技術専門職員
Review Section/Research Field	Principal Investigator Basic Section 58020:Hygiene and public health-related: including laboratory approach Except Principal Investigator Basic Section 46020:Anatomy and histopathology of nervous system-related / Medium-sized Section 45:Biology at organismal to population levels and anthropology, and related fields / Basic Section 51010:Basic brain sciences-related
Keywords	Principal Investigator 発達神経毒性 / 農薬曝露 / 神経発達障害 / グルホシネート / シナプス調節 / 神経毒性 / ピレスロイド系農薬 / 有機リン系農薬 / 神経シナプス形成 Except Principal Investigator スプライシング … More / マイクロエクソン / シナプス形成 / シナプスオーガナイザー / シナプス / ヒト脳 / シナプス誘導タンパク質 / 標的選別 / 神経発達障害 / ルシフェラーゼ / 生体イメージング / 脳 / BCAS1 / オリゴデンドロサイト / BAC / トランスジェニックマウス / ミエリン Less

シナプスの形成と再編を司るシナプス誘導遺伝子マイクロエクソン選択の分子細胞基盤
- Principal Investigator
  
  吉田知之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  University of Toyama
ヒトとマウスのシナプス誘導因子の動作原理の違いから紐解くヒトの脳機能進化
- Principal Investigator
  
  吉田知之
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 45:Biology at organismal to population levels and anthropology, and related fields
- Research Institution
  University of Toyama
Investigation of molecular basis of developmental synapse pathology by glufosinate exposurePrincipal Investigator
- Principal Investigator
  
  和泉宏謙
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  University of Toyama
Testing the Adult Myelination Hypothesis by Luminescence Observation and Manipulation of Myelin Formation
- Principal Investigator
  
  Ishimoto Tetsuya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51010:Basic brain sciences-related
- Research Institution
  University of Toyama
Molecular mechanisms for spatiotemporal and target specific regulation of neuronal synapse formation
- Principal Investigator
  
  Yoshida Tomoyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  University of Toyama
Effects of pesticide exposure on central synapse formationPrincipal Investigator
- Principal Investigator
  
  Izumi Hironori
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  University of Toyama

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Cancer‐associated point mutations within the extracellular domain of PTPRD affect protein stability and HSPG interaction2024
- Author(s)
  Matsui Yu、Imai Ayako、Izumi Hironori、Yasumura Misato、Makino Teruhiko、Shimizu Tadamichi、Sato Makoto、Mori Hisashi、Yoshida Tomoyuki
- Journal Title
  
  The FASEB Journal
  
  Volume: 38 Issue: 7
- DOI
  10.1096/fj.202302279rr
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K09644
[Journal Article] Differential contribution of canonical and noncanonical NLGN3 pathways to early social development and memory performance2024
- Author(s)
  Li LY, Imai A, Izumi H, Inoue R, Koshidaka Y, Takao K, Mori H, Yoshida T.
- Journal Title
  
  Mol Brain
  
  Volume: 17 Issue: 1 Pages: 16-16
- DOI
  10.1186/s13041-024-01087-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18151, KAKENHI-PROJECT-23K09644, KAKENHI-PROJECT-23K27276
[Journal Article] 老化促進モデルマウス（SAM）におけるゲノム編集2024
- Author(s)
  和泉　宏謙、吉田　知之、今井　彩子、黒澤　信幸、磯部　正治、森　寿
- Journal Title
  
  生理学技術研究会報告・生物学技術研究会報告合同技術研究会報告
  
  Volume: 46
- Data Source
  KAKENHI-PROJECT-23K09644
[Journal Article] Developmental synapse pathology triggered by maternal exposure to the herbicide glufosinate ammonium2023
- Author(s)
  Izumi H, Demura M, Imai A, Ogawa R, Fukuchi M, Okubo T, Tabata T, Mori H, Yoshida T.
- Journal Title
  
  Front Mol Neurosci
  
  Volume: 16 Pages: 1298238-1298238
- DOI
  10.3389/fnmol.2023.1298238
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18151, KAKENHI-PROJECT-22K07319, KAKENHI-PROJECT-23K09644, KAKENHI-PROJECT-23K27276
[Journal Article] グルホシネートの発達神経毒性のリスク評価2022
- Author(s)
  和泉宏謙, 出村舞奈, 今井彩子, 吉田知之, 小川良平, 森寿
- Journal Title
  
  生理学技術研究会報告
  
  Volume: 44
- Data Source
  KAKENHI-PROJECT-19K19407
[Journal Article] Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice2021
- Author(s)
  Yoshida T, Yamagata A, Imai A, Kim J, Izumi H, Nakashima S, Shiroshima T, Maeda A, Iwasawa-Okamoto S, Azechi K, Osaka F, Saitoh T, Maenaka K, Shimada T, Fukata Y, Fukata M, Matsumoto J, Nishijo H, Takao K, Tanaka S, Okabe S, Tabuchi K, Uemura T, Mishina M, Mori H & Fukai S
- Journal Title
  
  Nature Communications
  
  Volume: 12(1) Issue: 1 Pages: 1848-1848
- DOI
  10.1038/s41467-021-22059-6
- NAID
  120006996978
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06716, KAKENHI-PROJECT-19K22439, KAKENHI-PROJECT-19K22548, KAKENHI-PROJECT-20K21444, KAKENHI-PROJECT-18H05213, KAKENHI-PUBLICLY-19H04744, KAKENHI-PUBLICLY-19H04974, KAKENHI-PUBLICLY-19H05010, KAKENHI-PUBLICLY-20H04915, KAKENHI-ORGANIZER-20H05894, KAKENHI-PROJECT-18H03983, KAKENHI-PROJECT-20H00459, KAKENHI-PROJECT-19H03331, KAKENHI-PROJECT-19H03538, KAKENHI-PROJECT-19J10216, KAKENHI-PROJECT-18K06888, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K19407, KAKENHI-PROJECT-20H03350, KAKENHI-PLANNED-20H05895, KAKENHI-PROJECT-20H00481, KAKENHI-PROJECT-19H03162, KAKENHI-PROJECT-19H03544, KAKENHI-ORGANIZER-17H06413
[Journal Article] Generation and characterization of a Meflin-CreERT2 transgenic line for lineage tracing in white adipose tissue2021
- Author(s)
  Kuwano Takahide, Izumi Hironori, Aslam Muhammad Rahil, Igarashi Yoshiko, Bilal Muhammad, Nishimura Ayumi, Watanabe Yoshiyuki, Nawaz Allah, Kado Tomonobu, Ikuta Koichi, Yamamoto Seiji, Sasahara Masakiyo, Fujisaka Shiho, Yagi Kunimasa, Mori Hisashi, Tobe Kazuyuki
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 3 Pages: e0248267-e0248267
- DOI
  10.1371/journal.pone.0248267
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10204, KAKENHI-PROJECT-18K06888, KAKENHI-PROJECT-18K08505, KAKENHI-PROJECT-19K19407, KAKENHI-PROJECT-20K22733, KAKENHI-PROJECT-20H03730, KAKENHI-PROJECT-21H02713, KAKENHI-PROJECT-21K10300
[Journal Article] CRISPR/Cas9 システムを用いたノックインマウスの作製2021
- Author(s)
  和泉宏謙、吉田知之、森寿
- Journal Title
  
  生理学技術研究会報告
  
  Volume: 43
- Data Source
  KAKENHI-PROJECT-19K19407
[Journal Article] BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities.2021
- Author(s)
  Yaku K, Palikhe S, Izumi H, Yoshida T, Hikosaka K, Hayat F, Karim M, Iqbal T, Nitta Y, Sato A, Migaud ME, Ishihara K, Mori H, Nakagawa T
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 6767-6767
- DOI
  10.1038/s41467-021-27080-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21444, KAKENHI-PROJECT-19K19407, KAKENHI-PUBLICLY-21H00190, KAKENHI-PROJECT-20H03350, KAKENHI-PROJECT-21K11593, KAKENHI-PROJECT-20K20655
[Journal Article] TBX5 R264K acts as a modifier to develop dilated cardiomyopathy in mice independently of T-box pathway2020
- Author(s)
  Miyao N., Hata Y., Izumi H., Nagaoka R., Oku Y., Takasaki I., Ishikawa T., Takarada S., Okabe M., Nakaoka H., Ibuki K., Ozawa S., Yoshida T., Hasegawa H., Makita N., Nishida N., Mori H., Ichida F., Hirono K.
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 4 Pages: 0227393-0227393
- DOI
  10.1371/journal.pone.0227393
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19550, KAKENHI-PROJECT-18KK0245, KAKENHI-PUBLICLY-19H04744, KAKENHI-PROJECT-18K07785, KAKENHI-PROJECT-19K08295, KAKENHI-PROJECT-18H02808, KAKENHI-PROJECT-18K15894, KAKENHI-PROJECT-18K07365, KAKENHI-PROJECT-20H03350
[Presentation] 老化促進モデルマウス（SAM）におけるゲノム編集2024
- Author(s)
  和泉　宏謙
- Organizer
  第46回生理学技術研究会
- Data Source
  KAKENHI-PROJECT-23K09644
[Presentation] 母体へのグルホシネート曝露による発達期シナプス病態の解析2024
- Author(s)
  和泉　宏謙、出村　舞奈、今井　彩子、小川　良平、福地　守、大久保　泰策、田端　俊英、森　寿、吉田　知之
- Organizer
  第23回分子予防環境医学研究会
- Data Source
  KAKENHI-PROJECT-23K09644
[Presentation] グルホシネート曝露による発達期シナプス病態の解析2023
- Author(s)
  和泉宏謙、出村舞奈、今井彩子、小川良平、大久保泰策、吉田知之、森寿
- Organizer
  第50回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-23K18151
[Presentation] Ptprd遺伝子マイクロエクソンスプライシングの時空間的制御と行動発達における役割2023
- Author(s)
  今井彩子、和泉宏謙、川瀬修平、北嶋悠希、深井周也、高雄啓三、森寿、吉田知之
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-23K18151
[Presentation] 自閉症関連タンパク質NLGN3による早期社会性発達及び記憶の調節機構2023
- Author(s)
  李林煜、今井彩子、和泉宏謙、井上蘭、高雄啓三、森寿、吉田知之
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K18151
[Presentation] Ptprd遺伝子マイクロエクソンスプライシングの時空間的制御と行動発達における役割2023
- Author(s)
  今井彩子、和泉宏謙、川瀬修平、北嶋悠希、深井周也、高雄啓三、森寿、吉田知之
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-23K27276
[Presentation] PTPRDの細胞外領域におけるがん関連点突然変異の機能的特性評価2023
- Author(s)
  松井悠、今井彩子、和泉宏謙、牧野輝彦、清水忠道、吉田知之、森寿
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K27276
[Presentation] Developmental synapse pathology by exposure to herbicide glufosinate ammonium2023
- Author(s)
  Hironori Izumi, Maina Demura, Ayako Imai, Ryohei Ogawa, Taisaku Okubo, Tomoyuki Yoshida, Hisahi Mori
- Organizer
  第50回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-23K09644
[Presentation] PTPRDの細胞外領域におけるがん関連点突然変異の機能的特性評価2023
- Author(s)
  松井悠、今井彩子、和泉宏謙、牧野輝彦、清水忠道、吉田知之、森寿
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K18151
[Presentation] グルホシネート曝露による発達期シナプス病態の解析2023
- Author(s)
  和泉宏謙、出村舞奈、今井彩子、小川良平、大久保泰策、吉田知之、森寿
- Organizer
  第50回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-23K27276
[Presentation] 自閉症関連タンパク質NLGN3による早期社会性発達及び記憶の調節機構2023
- Author(s)
  李林煜、今井彩子、和泉宏謙、井上蘭、高雄啓三、森寿、吉田知之
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K27276
[Presentation] PTPδ遺伝子のマイクロエクソン選択機構の解明2022
- Author(s)
  赤羽絢夏、今井彩子、和泉宏謙、北嶋悠希、川瀬修平、森寿、吉田知之
- Organizer
  第40回日本生化学会北陸支部大会
- Data Source
  KAKENHI-PROJECT-20H03350
[Presentation] グルホシネートの発達神経毒性のリスク評価2022
- Author(s)
  和泉宏謙, 出村舞奈, 今井彩子, 吉田知之, 小川良平, 森寿
- Organizer
  第44回生理学技術研究会
- Data Source
  KAKENHI-PROJECT-19K19407
[Presentation] Distinct roles of canonical and non-canonical neuroligin 3 pathways in behavioral regulation2022
- Author(s)
  Ayako Imai, Hironori Izumi, Yumie Koshidaka, Keizo Takao, Hisashi Mori, Tomoyuki Yoshida
- Organizer
  NEURO2022
- Data Source
  KAKENHI-PROJECT-20H03350
[Presentation] Effect of the herbicide glufosinate-ammonium exposure on neural synapse formation2021
- Author(s)
  Izumi Hironori, Maina Demura, Ayako Imai, Tomoyuki Yoshida, Ryohei Ogawa, Hisashi Mori
- Organizer
  第4回医薬品毒性機序研究会
- Data Source
  KAKENHI-PROJECT-19K19407
[Presentation] シナプス形成を指標としたグルホシネート曝露による中枢神経系への影響評価2021
- Author(s)
  和泉宏謙、出村舞奈、今井彩子、吉田知之、小川良平、森寿
- Organizer
  第55回日本実験動物技術者協会総会
- Data Source
  KAKENHI-PROJECT-19K19407
[Presentation] シナプス形成を指標としたグルホシネート曝露による中枢神経系への影響評価2021
- Author(s)
  和泉宏謙, 出村舞奈, 今井彩子, 吉田知之, 小川良平, 森寿
- Organizer
  第55回日本実験動物技術者協会総会
- Data Source
  KAKENHI-PROJECT-20H03350
[Presentation] Effect of the herbicide glufosinate-ammonium exposure on neural synapse formation2021
- Author(s)
  Izumi Hironori，Maina Demura，Ayako Imai, Tomoyuki Yoshida, Ryohei Ogawa, Hisashi Mori
- Organizer
  第4回医薬品毒性機序研究会
- Data Source
  KAKENHI-PROJECT-20H03350
[Presentation] 新規ルシフェラーゼ基質アカルミネ塩酸塩「TokeOni」を利用した生体マウス脳内における神経活動依存的なBDNF遺伝子発現誘導の可視化2021
- Author(s)
  福地守, 齊藤亮平, 齊藤亮平, 牧昌次郎, 萩原なみ, 中島夢奈, 和泉宏謙, 三反崎聖, 森寿
- Organizer
  第141回日本薬学会
- Data Source
  KAKENHI-PROJECT-19K19407
[Presentation] CRISPR/Cas9 システムを用いたノックインマウスの作製2021
- Author(s)
  和泉宏謙
- Organizer
  第43回生理学技術研究会
- Data Source
  KAKENHI-PROJECT-19K19407
[Presentation] グルホシネートばく露に伴う中枢神経系への影響評価2020
- Author(s)
  和泉宏謙、出村舞奈、今井彩子、吉田知之、小川良平、森寿
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K19407
[Presentation] Microexon splicing of Ptprd gene controls locomotor activity and social behavior2020
- Author(s)
  Ayako Tabata-Imai, Mizuki Sendo, Hironori Izumi, Keizo Takao, Hisashi Mori, Tomoyuki Yoshida
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-20H03350

1. Yoshida Tomoyuki (90372367)

# of Collaborated Projects: 4 results

# of Collaborated Products: 20 results
2. Ishimoto Tetsuya (40397170)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. YAGI Kunimasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 蒔田直昌

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 金主賢

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Izumi Hironori 和泉 宏謙

Research Projects

Research Products

Co-Researchers

シナプスの形成と再編を司るシナプス誘導遺伝子マイクロエクソン選択の分子細胞基盤

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒトとマウスのシナプス誘導因子の動作原理の違いから紐解くヒトの脳機能進化

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of molecular basis of developmental synapse pathology by glufosinate exposurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Testing the Adult Myelination Hypothesis by Luminescence Observation and Manipulation of Myelin Formation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms for spatiotemporal and target specific regulation of neuronal synapse formation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effects of pesticide exposure on central synapse formationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Cancer‐associated point mutations within the extracellular domain of PTPRD affect protein stability and HSPG interaction2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differential contribution of canonical and noncanonical NLGN3 pathways to early social development and memory performance2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 老化促進モデルマウス（SAM）におけるゲノム編集2024

Author(s)

Journal Title

Data Source

[Journal Article] Developmental synapse pathology triggered by maternal exposure to the herbicide glufosinate ammonium2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] グルホシネートの発達神経毒性のリスク評価2022

Author(s)

Journal Title

Data Source

[Journal Article] Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Generation and characterization of a Meflin-CreERT2 transgenic line for lineage tracing in white adipose tissue2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CRISPR/Cas9 システムを用いたノックインマウスの作製2021

Author(s)

Journal Title

Data Source

[Journal Article] BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities.2021

Author(s)

Izumi Hironori 和泉宏謙