ASAI Tomohiro 浅井知浩

Researcher Number	00381731
Other IDs
Affiliation (Current)	2022: 静岡県立大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2022: 静岡県立大学, 薬学部, 教授 2012 – 2017: 静岡県立大学, 薬学部, 准教授 2012: 静岡県立大学, 大学院・薬学研究科, 准教授 2004 – 2012: 静岡県立大学, 薬学部, 講師 2009: University of Shizuoka, 大学院・薬学研究科, 講師
Review Section/Research Field	Principal Investigator Physical pharmacy / Medical pharmacy / Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related Except Principal Investigator Physical pharmacy / Biological Sciences / Medical pharmacy / Cardiovascular medicine / Gastroenterology / Veterinary medical science / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Basic Section 90110:Biomedical engineering-related / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
Keywords	Principal Investigator RNA干渉 / siRNA / がん / DDS / drug delivery system / ドラッグデリバリー / リポソーム / 脂質ナノ粒子 / マイクロディスク / 好中球 … More / 炎症 / 脳梗塞 / 腫瘍新生血管傷害療法 / 膵がん治療 / 同所移植モデル / 標的化リポソーム / 抗がん剤 / ペプチド / mTOR / リボソーム / ドラッグデリバリーシステム / small interfering RNA / がん治療 / ＲＮＡ干渉 / ｓｉＲＮＡ / ＤＤＳ / 合成致死性 / siRNA送達 / PARP1 / PTEN / 合成致死 / オートファジー / verteporfin / 薬学 / superoxide dismutase / mRNA / 抗原提示細胞 / ワクチン … More Except Principal Investigator リポソーム / DDS / 薬物送達システム / がん治療 / ナノ粒子 / 血管新生 / 標的化 / ドラッグデリバリー / 逆標的化 / 薬物送達 / 腫瘍新生血管傷害療法 / 新生血管 / ターゲティング / アレルギー / 虚血性疾患 / 脳梗塞 / アクティブターゲティング / 自己免疫疾患 / 膵がんモデル / 2D-DIGE / 複標的化 / 花粉症 / 免疫疾患 / ABC現象 / Cryj1 / Cryj 1 / Cryjl / タムスロシン / 細胞保護効果 / ナノ粒 / 脳虚血再灌流障害 / アシアロエリスロポエチン / 薬学 / 長期血中滞留性 / ファージディスプレイペプチドライブラリー / バイオパニング / ＤＤＳ / 核酸医薬品 / RNA干渉 / ポリカチオンリポソーム / マイクロRNA / 血管正常化 / TEPA-PCL / miR499 / miR-499 / 腫瘍血管新生 / 併用療法 / ドキソルビシン / 新生血管標的化 / 腫瘍 / Antineovascular Therapy / Cancer / Drug Delivery System (DDS) / Liposome / Targeting / Active Targeting / Angiogenesis / Photodynamic Therapy / 減感作 / リボソーム / reverse targeting / active targeting / drug delivery system / liposome / desensitization / allergy / autoimmune disease / HB-EGF抗体 / HB-EGF抗体結合ベクター / 不安定プラーク / 循環器・高血圧 / HB-EGF / バイオテクノロジー / 炎症性腸疾患 / エピゲノム / マクロファージ / クロマチン構造 / HDAC阻害剤 / 腸管マクロファージ / FAIRE / ノンインプリント人工抗体 / プラスチック抗体 / 敗血症 / ヒストン / 毒素の中和 / 膜流動性 / ポリマー粒子 / ポリマーリガンド / 毒素 / 中和活性 / 人工抗体 / 解毒 / scFv / 狂犬病 / 経鼻接種 / 治療 / 狂犬病ウイルス / intrabody / ピンポイントDDS / 小型抗体 / 脳梗塞治療 / ファスジル / 組織プラスミノーゲン活性化因子 / 脳血管疾患 / 脳血管障害 / 治療可能時間 / 血栓溶解剤 / ＰＤＧＦ / 脳出血抑制 / ＭＭＰ / 自己免疫疾患治療 / ドラッグデリバリーシステム / 自己抗原修飾リポソーム / 多発性硬化症 / 実験的自己免疫性脳脊髄炎 / 脾臓 / 抗原特異的T細胞 / 標的化DDS / T細胞 / 再発寛解型 / フィンゴリモド / 神経免疫疾患 / 合成高分子 / 糖尿病 / 腎疾患 / 分子認識 / 多価効果 / 潰瘍性大腸炎 / 体内動態 / 経口投与 / N-Isopropylacrylamide / 腎不全 / 抗体 / タイトジャンクション / クローディン / 肺がん / 機能性食品 / 短鎖ペプチド Less

抗原提示細胞を標的としたmRNA/LNP製剤の開発と個別化がん免疫療法への応用Principal Investigator
- Principal Investigator
  
  浅井知浩
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  University of Shizuoka
好中球を担体とした独創的DDSの開発と炎症性疾患治療への応用Principal Investigator
- Principal Investigator
  
  浅井知浩
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  University of Shizuoka
Design and construction of neutrophil-mediated drug delivery systemPrincipal Investigator
- Principal Investigator
  
  Asai Tomohiro
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  University of Shizuoka
Development of plastic antibodies that inhibit intestinal absorption of target molecules
- Principal Investigator
  
  Koide Hiroyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  University of Shizuoka
Clarification of the molecular mechanism and establishment of the basis for drug development toward epithelial cancer barrier
- Principal Investigator
  
  五十里彰
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Gifu Pharmaceutical University
Innovative DDS medicine for the complete recovery from autoimmune diseases
- Principal Investigator
  
  Shimizu Kosuke
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Hamamatsu University School of Medicine
Development of functional lipid nanoparticles for RNA interference-based therapyPrincipal Investigator
- Principal Investigator
  
  Tomohiro Asai
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka
Development of liposomal plastic antibody for novelDDS and applicaion for sepsis treatment
- Principal Investigator
  
  Oku Naoto
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka
Development of treatment of rabies using drug delivery system to virus-infected cells
- Principal Investigator
  
  Kaku Yoshihiro
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Veterinary medical science
- Research Institution
  National Institute of Infectious Diseases
Development of FA-Snap, a smart DDS drug, for proposing an innovative therapeutic modality of ischemic stroke.
- Principal Investigator
  
  OKU Naoto
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Teikyo University
  University of Shizuoka
Development of antibody-drug conjugate to diagnose and treat vulnerable plaque
- Principal Investigator
  
  MINAMINO TETSUO
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kagawa University
  Osaka University
Novel strategy of tumor treatiment via the normalization of tumor vasculature by microRNA
- Principal Investigator
  
  Oku Naoto
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka
Delivery of siRNA for synthetic lethality-based cancer therapyPrincipal Investigator
- Principal Investigator
  
  Tomohiro Asai
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka
Epigenetic regulation of macrophage function in inflammatory bowel disease
- Principal Investigator
  
  Kobayashi Taku
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kitasato University
Innovation of a novel technology for supporting the development of DDS drugs and protein medicines by controling their pharmacokinetics.
- Principal Investigator
  
  OKU NAOTO
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka
Development of novel nanoparticles for DDS, and establishment of Therapeutic modality for brain ischemia by use of these nanoparticles.
- Principal Investigator
  
  OKU Naoto
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka
Systemic delivery system of siRNAfor cancertreatmentPrincipal Investigator
- Principal Investigator
  
  ASAI Tomohiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka
難治がんの克服を目標した発展型腫瘍新生血管標的化DDSに関する研究
- Principal Investigator
  
  奥直人
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Shizuoka
A novel targeting DDS for the treatment of autoimmune diseases and allergy
- Principal Investigator
  
  OKU Naoto
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka
Development of systemic delivery system for RNAi-based therapiesPrincipal Investigator
- Principal Investigator
  
  ASAI Tomohiro
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Shizuoka
Development of Radical Treatment Modality for Curing Allergies and Immune Diseases by a Novel Consept, RTDDS
- Principal Investigator
  
  OKU Naoto
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Shizuoka
難治がんの克服を目標とした腫瘍新生血管標的化DDSに関する包括的研究
- Principal Investigator
  
  OKU Naoto
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Shizuoka
腫瘍新生血管傷害療法を応用した膵がんに対する新規アプローチPrincipal Investigator
- Principal Investigator
  
  浅井知浩
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Shizuoka
Establishment of Antineovascular Therapy by use of Structure-recognizing targeting probes
- Principal Investigator
  
  OKU Naoto
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  UNIVERSITY OF SHIZUOKA

[Book] Design and Delivery of siRNA Therapeutics. Methods in Molecular Biology.2020
- Author(s)
  Koide H, Yonezawa S, Asai T
- Total Pages
  9
- Publisher
  Springer Nature
- ISBN
  9781071612989
- Data Source
  KAKENHI-PROJECT-20K21905
[Book] DDS先端技術の製剤への応用開発　第3節　脂質ナノ粒子を用いた核酸医薬デリバリー2017
- Author(s)
  岡本彩香, 浅井知浩, 奥直人
- Total Pages
  8
- Publisher
  株式会社　技術情報協会
- Data Source
  KAKENHI-PROJECT-16K08201
[Book] DDSキャリア作成プロトコル集2015
- Author(s)
  浅井知浩, 奥直人
- Total Pages
  6
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-25460041
[Book] Polymeric Biomaterials2013
- Author(s)
  Koide H, Asai T, Shimizu K, Oku N
- Total Pages
  28
- Publisher
  CRC Press
- Data Source
  KAKENHI-PROJECT-25460041
[Book] DDS技術の実用化手法2013
- Author(s)
  浅井知浩, 奥直人
- Total Pages
  6
- Publisher
  株式会社　技術情報協会
- Data Source
  KAKENHI-PROJECT-25460041
[Book] 非経口投与製剤の開発と応用―次世代型医薬品の新規投与形態の開拓を目指して―2013
- Author(s)
  浅井知浩, 奥直人
- Total Pages
  6
- Publisher
  株式会社　シーエムシー出版
- Data Source
  KAKENHI-PROJECT-25460041
[Book] Drug carrier systems for anticancer agents.2013
- Author(s)
  H. Koide, T. Asai, K. Shimizu, N. Oku
- Publisher
  CRC Press
- Data Source
  KAKENHI-PROJECT-22790045
[Book] Polyamine-lipid conjugates as effective gene carriers: chemical structure, morphology, and gene transfer activity.2011
- Author(s)
  T. Dewa, T. Asai, N. Oku, M. Nango
- Publisher
  In Tech
- Data Source
  KAKENHI-PROJECT-22790045
[Book] Angiogenic Vessel-Targeting DDS by Liposomalized Oligopeptides. Methods in Molecular Biology, chapter 232010
- Author(s)
  Asai, T., Oku, N.
- Publisher
  Humana Press
- Data Source
  KAKENHI-PROJECT-19790131
[Book] リポソーム応用の新展開2005
- Author(s)
  浅井知浩ら(秋吉一成/辻井薫編)
- Total Pages
  28
- Publisher
  NTS
- Data Source
  KAKENHI-PROJECT-17790128
[Book] Methods Enzymol.2005
- Author(s)
  Asai, T.et al.(Nejat Duzgunes編)
- Total Pages
  14
- Publisher
  ELSEVIER
- Data Source
  KAKENHI-PROJECT-17790128
[Journal Article] Cytosolic protein delivery using pH-responsive, charge-reversible lipid nanoparticles2021
- Author(s)
  Hirai Yusuke、Hirose Hisaaki、Imanishi Miki、Asai Tomohiro、Futaki Shiroh
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Pages: 19896-19896
- DOI
  10.1038/s41598-021-99180-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21905, KAKENHI-PROJECT-20J23340
[Journal Article] Synthetic hydrogel nanoparticles for sepsis therapy2021
- Author(s)
  Koide Hiroyuki、Okishima Anna、Hoshino Yu、Kamon Yuri、Yoshimatsu Keiichi、Saito Kazuhiro、Yamauchi Ikumi、Ariizumi Saki、Zhou Yuqi、Xiao Ting-Hui、Goda Keisuke、Oku Naoto、Asai Tomohiro、Shea Kenneth J.
- Journal Title
  
  Nature Communications
  
  Volume: 12 Pages: 5552-5552
- DOI
  10.1038/s41467-021-25847-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21905, KAKENHI-PROJECT-19H04450
[Journal Article] Enhancement of target toxin neutralization effect in vivo by PEGylation of multifunctionalized lipid nanoparticles2021
- Author(s)
  Koide Hiroyuki、Suzuki Hikaru、Ochiai Hiroki、Egami Hiromichi、Hamashima Yoshitaka、Oku Naoto、Asai Tomohiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 555 Pages: 32-39
- DOI
  10.1016/j.bbrc.2021.03.073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21905, KAKENHI-PROJECT-19H04450
[Journal Article] New strategy for MS treatment with autoantigen-modified liposomes and their therapeutic effect2021
- Author(s)
  Shimizu Kosuke、Agata Kazuki、Takasugi Shohei、Goto Shungo、Narita Yudai、Asai Tomohiro、Magata Yasuhiro、Oku Naoto
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 335 Pages: 389-397
- DOI
  10.1016/j.jconrel.2021.05.027
- NAID
  120007159864
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06593, KAKENHI-PROJECT-20K21905, KAKENHI-PROJECT-21H02614
[Journal Article] siRNA Vehicles for High Endosomal Escapability2021
- Author(s)
  Koide Hiroyuki、Yonezawa Sei、Asai Tomohiro
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 2282 Pages: 171-179
- DOI
  10.1007/978-1-0716-1298-9_11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21905, KAKENHI-PROJECT-19H04450
[Journal Article] Upregulation of Chemoresistance by Mg2+ Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells2021
- Author(s)
  Onuma Saki、Manabe Aya、Yoshino Yuta、Matsunaga Toshiyuki、Asai Tomohiro、Ikari Akira
- Journal Title
  
  Cells
  
  Volume: 10 Pages: 1179-1179
- DOI
  10.3390/cells10051179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21905
[Journal Article] Design of abiotic polymer ligand-decorated lipid nanoparticles for effective neutralization of target toxins in the blood2021
- Author(s)
  Koide Hiroyuki、Yamauchi Ikumi、Hoshino Yu、Yasuno Go、Okamoto Takumi、Akashi Sotaro、Saito Kazuhiro、Oku Naoto、Asai Tomohiro
- Journal Title
  
  Biomaterials Science
  
  Volume: 9 Pages: 5588-5598
- DOI
  10.1039/d1bm00515d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21905, KAKENHI-PROJECT-19H04450
[Journal Article] Design of synthetic polymer nanoparticles that inhibit glucose absorption from the intestine2021
- Author(s)
  Koide Hiroyuki、Hayashi Naoki、Yasuno Go、Okishima Anna、Hoshino Yu、Egami Hiromichi、Hamashima Yoshitaka、Oku Naoto、Asai Tomohiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 561 Pages: 1-6
- DOI
  10.1016/j.bbrc.2021.05.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21905, KAKENHI-PROJECT-19H04450
[Journal Article] Influence of Purification Process on the Function of Synthetic Polymer Nanoparticles2021
- Author(s)
  Yasuno Go、Koide Hiroyuki、Oku Naoto、Asai Tomohiro
- Journal Title
  
  CHEMICAL & PHARMACEUTICAL BULLETIN
  
  Volume: 69 Issue: 8 Pages: 773-780
- DOI
  10.1248/cpb.c21-00273
- NAID
  130008070212
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21905, KAKENHI-PROJECT-19H04450
[Journal Article] Claudin-2 binding peptides, VPDSM and DSMKF, down-regulate claudin-2 expression and anticancer resistance in human lung adenocarcinoma A549 cells2020
- Author(s)
  Nasako H, Akizuki R, Takashina Y, Ishikawa Y, Shinoda T, Shirouzu M, Asai T, Matsunaga T, Endo S, Ikari A.
- Journal Title
  
  Biochemica et Biophysica Acta
  
  Volume: 1867 Pages: 118642-118642
- DOI
  10.1016/j.bbamcr.2019.118642
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07315, KAKENHI-PROJECT-19K07792, KAKENHI-PROJECT-20K21905, KAKENHI-PROJECT-19H03373
[Journal Article] Engineering of Lipid Nanoparticles by the Multifunctionalization of the Surface with Amino Acid Derivatives for the Neutralization of a Target Toxic Peptide2020
- Author(s)
  Koide H, Hirano S, Ide T, Saito K, Suzuki H, Yasuno G, Hamashima Y, Yonezawa S, Oku N, Asai T
- Journal Title
  
  Advanced Functional Materials
  
  Volume: 31 Pages: 2005641-2005641
- DOI
  10.1002/adfm.202005641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21905, KAKENHI-PROJECT-19H04450
[Journal Article] Charge-reversible lipid derivative: A novel type of pH-responsive lipid for nanoparticle-mediated siRNA delivery2020
- Author(s)
  Hirai Y, Saeki R, Song F, Koide H, Fukata N, Tomita K, Maeda N, Oku N, Asai T
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 585 Pages: 119479-119479
- DOI
  10.1016/j.ijpharm.2020.119479
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21905, KAKENHI-PROJECT-20K16082
[Journal Article] Recent advances in siRNA delivery mediated by lipid-based nanoparticles.2020
- Author(s)
  Yonezawa S, Koide H, Asai T
- Journal Title
  
  Adv Drug Deliv Rev.
  
  Volume: 154-155 Pages: 64-78
- DOI
  10.1016/j.addr.2020.07.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21905
[Journal Article] Release rate is a key variable affecting the therapeutic effectiveness of liposomal fasudil for the treatment of cerebral ischemia/reperfusion injury.2020
- Author(s)
  Yanagida Y, Namba M, Fukuta T, Yamamoto H, Yanagida M, Honda M, Oku N, Asai T
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 531 Pages: 622-627
- DOI
  10.1016/j.bbrc.2020.07.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21905
[Journal Article] Challenge for oral delivery of middle-molecular drugs: Use of osmolarity-sensitive liposome as a drug carrier in the GI tract.2020
- Author(s)
  Minami K, Takazawa A, Taniguchi Y, Higashino H, Kataoka M, Asai T, Oku N, Yamashita S
- Journal Title
  
  J Drug Deliv Sci Technol.
  
  Volume: 56 Pages: 101041-101041
- DOI
  10.1016/j.jddst.2019.04.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21905
[Journal Article] Applications of Liposomal Drug Delivery Systems to Develop Neuroprotective Agents for the Treatment of Ischemic Stroke2019
- Author(s)
  Fukuta T, Ishii T, Asai T, Oku N.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 42 Issue: 3 Pages: 319-326
- DOI
  10.1248/bpb.b18-00683
- NAID
  130007606450
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05081, KAKENHI-PROJECT-17H06906, KAKENHI-PROJECT-16K08201, KAKENHI-PROJECT-15H02569
[Journal Article] Rigorous control of vesicle-forming lipid pKa by fluorine-conjugated bioisosteres for gene-silencing with siRNA2019
- Author(s)
  Okamoto A, Koide H, Morita N, Hirai Y, Kawato Y, Egami H, Hamashima Y, Asai T, Dewa T, Oku N.
- Journal Title
  
  J. Control. Release
  
  Volume: 295 Pages: 87-92
- DOI
  10.1016/j.jconrel.2018.12.044
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08201, KAKENHI-PROJECT-17K14519, KAKENHI-PROJECT-19H03353
[Journal Article] Engineering the Binding Kinetics of Synthetic Polymer Nanoparticles for siRNA Delivery2019
- Author(s)
  Hiroyuki Koide, Tatsuya Fukuta, Anna Okishima, Saki Ariizumi, Chiaki Kiyokawa, Hiroki Tsuchida, Masahiko Nakamoto, Keiichi Yoshimatsu, Hidenori Ando, Takehisa Dewa, Tomohiro Asai, Naoto Oku, Yu Hoshino, Kenneth J. Shea
- Journal Title
  
  Biomacromolecules
  
  Volume: 20 Pages: 3648-3657
- DOI
  10.1021/acs.biomac.9b00611
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04450
[Journal Article] Shea KJ. Sequestering and inhibiting a vascular endothelial growth factor in vivo by systemic administration of a synthetic polymer nanoparticle.2019
- Author(s)
  Koide H, Yoshimatsu K, Hoshino Y, Ariizumi S, Okishima A, Ide T, Egami H, Hamashima Y, Nishimura Y, Kanazawa H, Miura Y, Asai T, Oku N,
- Journal Title
  
  J. Control. Release.
  
  Volume: 295 Pages: 13-20
- DOI
  10.1016/j.jconrel.2018.12.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08201
[Journal Article] Co-administration of liposomal fasudil and tissue plasminogen activator ameliorated ischemic brain damage in occlusion model rats prepared by photochemically induced thrombosis.2018
- Author(s)
  Fukuta T, Yanagida Y, Asai T, Oku N
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 495 Pages: 873-877
- DOI
  10.1016/j.bbrc.2017.11.107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08201, KAKENHI-PROJECT-16H05081
[Journal Article] Anticancer Efficacy of the Combination of Berberine and PEGylated Liposomal Doxorubicin in Meth A Sarcoma-Bearing Mice2018
- Author(s)
  Yahuafai J, Asai T, Oku N,
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 41 Issue: 7 Pages: 1103-1106
- DOI
  10.1248/bpb.b17-00989
- NAID
  130007387182
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08201
[Journal Article] Systemic Administration of siRNA with Anti-HB-EGF Antibody-Modified Lipid Nanoparticles for the Treatment of Triple-Negative Breast Cancer.2018
- Author(s)
  Okamoto A, Asai T, Hirai Y, Shimizu K, Koide H, Minamino T, Oku N
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 15 Pages: 1495-1504
- DOI
  10.1021/acs.molpharmaceut.7b01055
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08201, KAKENHI-PROJECT-17K14519, KAKENHI-PROJECT-15H04821, KAKENHI-PROJECT-15J11660
[Journal Article] A novel therapy for acute autoimmune myocarditis with nano-sized liposomal FK5062017
- Author(s)
  Okuda K, Fu HY, Matsuzaki T, Araki R, Tsuchida S, Thanikachalam PV, Fukuta T, Asai T, Yamato M, Sanada S, Asanuma H, Asano Y, Asakura M, Hanawa H, Hao H, Oku N, Takashima S, Kitakaze M, Sakata Y, Minamino T.
- Journal Title
  
  PLoS One
  
  Volume: 11
- DOI
  10.1371/journal.pone.0160944
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-15H04821, KAKENHI-PROJECT-14J10730, KAKENHI-PROJECT-26461134, KAKENHI-PROJECT-16K08201, KAKENHI-PROJECT-15K12542
[Journal Article] Process optimization by use of design of experiments: Application for liposomalization of FK506.2017
- Author(s)
  Toyota H, Asai T, Oku N
- Journal Title
  
  Eur J Pharm Sci.
  
  Volume: 102 Pages: 196-202
- DOI
  10.1016/j.ejps.2017.03.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08201, KAKENHI-PROJECT-16H05081
[Journal Article] 浸透圧感受性リポソームを用いた生理活性ペプチドの経口デリバリーシステムの構築.2017
- Author(s)
  南景子, 上原司, 高澤明日香, 東野晴輝, 片岡誠, 浅井知浩, 奥直人, 山下伸二
- Journal Title
  
  Progr. Drug Delivery Syst.
  
  Volume: 26 Pages: 33-35
- Data Source
  KAKENHI-PROJECT-16K08201
[Journal Article] Targeted delivery of anticancer drugs to tumor vessels by use of liposomes modified with a peptide identified by phage biopanning with human endothelial progenitor cells2017
- Author(s)
  Fukuta T, Asai T, Kiyokawa Y, Nakada T, Bessyo-Hirashima K, Fukaya N, Hyodo K, Takase K, Kikuchi H, Oku N.
- Journal Title
  
  Int. J. Pharm.
  
  Volume: 524 Pages: 364-372
- DOI
  10.1016/j.ijpharm.2017.03.059
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-14J10730, KAKENHI-PROJECT-16K08201, KAKENHI-PROJECT-15H02569
[Journal Article] Combination therapy with liposomal neuroprotectants and tissue plasminogen activator for treatment of ischemic stroke2017
- Author(s)
  Fukuta T, Asai T, Yanagida Y, Namba M, Koide H, Shimizu K, Oku N.
- Journal Title
  
  FASEB J.
  
  Volume: 印刷中 Pages: 1879-1890
- DOI
  10.1096/fj.201601209r
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02569, KAKENHI-PROJECT-14J10730, KAKENHI-PROJECT-16K08201, KAKENHI-PROJECT-16H05081
[Journal Article] 脳梗塞治療におけるリポソームDDS製剤の有用性2017
- Author(s)
  福田達也、浅井知浩、奥直人
- Journal Title
  
  オレオサイエンス
  
  Volume: 17 Pages: 15-22
- NAID
  130007687705
- Data Source
  KAKENHI-PROJECT-16H05081
[Journal Article] Rational designing of an antidote nanoparticle decorated with abiotic polymer ligands for capturing and neutralizing target toxins.2017
- Author(s)
  Koide H, Tsuchida H, Nakamoto M, Okishima A, Ariizumi S, Kiyokawa C, Asai T, Hoshino Y, Oku N
- Journal Title
  
  J Control Release.
  
  Volume: 68 Pages: 335-342
- DOI
  10.1016/j.jconrel.2017.10.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08201, KAKENHI-PROJECT-16K15111
[Journal Article] 脳梗塞治療におけるリポソームDDS製剤の有用性2017
- Author(s)
  福田達也, 浅井知浩, 奥直人
- Journal Title
  
  オレオサイエンス
  
  Volume: 17 Pages: 359-366
- NAID
  130007687705
- Data Source
  KAKENHI-PROJECT-16K08201
[Journal Article] リポソームDDS 製剤と血栓溶解剤併用による新規脳梗塞治療法の開発.2017
- Author(s)
  福田達也, 浅井知浩, 奥直人
- Journal Title
  
  Progr. Drug Delivery Syst.
  
  Volume: 26 Pages: 21-26
- Data Source
  KAKENHI-PROJECT-16K08201
[Journal Article] RNA干渉の増強とPlk1を標的としたsiRNAによるがん併用療法2016
- Author(s)
  橋本正寛、浅井知浩、奥直人
- Journal Title
  
  PROGRESS IN DRUG DELIVERY SYSTEM
  
  Volume: XXV Pages: 55-60
- Data Source
  KAKENHI-PROJECT-16K08201
[Journal Article] Non-invasive evaluation of neuroprotective drug candidates for cerebral infarction by PET imaging of mitochondrial complex-I activity2016
- Author(s)
  Tatsuya Fukuta, Tomohiro Asai, Takayuki Ishii, Hiroyuki Koide, Chiaki Kiyokawa, Masahiro Hashimoto, Takashi Kikuchi, Kosuke Shimizu, Norihiro Harada, Hideo Tsukada, Naoto Oku
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Pages: 30127-30127
- DOI
  10.1038/srep30127
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H02569, KAKENHI-PROJECT-14J10730, KAKENHI-PROJECT-16K08201, KAKENHI-PROJECT-16H05081
[Journal Article] Neuroprotection against cerebral ischemia/reperfusion injury by intravenous administration of liposomal fasudil2016
- Author(s)
  Fukuta T, Asai T, Sato A, Namba M, Yanagida Y, Kikuchi T, Koide H, Shimizu K, Oku N.
- Journal Title
  
  Int J Pharm.
  
  Volume: 506 Pages: 129-137
- DOI
  10.1016/j.ijpharm.2016.04.046
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-14J10730, KAKENHI-PROJECT-25460041, KAKENHI-PROJECT-15H02569, KAKENHI-PROJECT-16H05081
[Journal Article] Enhanced efficacy of doxorubicin by microRNA-499-mediated improvement of tumor blood flow2016
- Author(s)
  Okamoto A, Asai T, Ryu S, Ando H, Maeda N, Dewa T, Oku N.
- Journal Title
  
  J. Clin. Med.
  
  Volume: 5 Pages: 10-10
- DOI
  10.3390/jcm5010010
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15J11660, KAKENHI-PROJECT-25460041, KAKENHI-PROJECT-26670018
[Journal Article] One-step encapsulation of siRNA between lipid-layers of multi-layer polycation liposomes by lipoplex freeze-thawing2016
- Author(s)
  Koide H, Okamoto A, Tsuchida H, Ando H, Ariizumi S, Kiyokawa C, Hashimoto M, Asai T, Dewa T, Oku N.
- Journal Title
  
  J. Control. Release
  
  Volume: 228 Pages: 1-8
- DOI
  10.1016/j.jconrel.2016.01.032
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15J11660, KAKENHI-PROJECT-25460041
[Journal Article] Specific delivery of an immunosuppressive drug to splenic B cells by antigen-modified liposomes and its anti-allergic effect2016
- Author(s)
  Shimizu K, Miyauchi H, Urakami T, Yamamura-Ichikawa K, Yonezawa S, Asai T, Oku N
- Journal Title
  
  J Drug Target
  
  Volume: - Pages: 1-29
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460041
[Journal Article] 脂質ナノ粒子を用いたsiRNAデリバリー技術の開発とがん治療への応用2016
- Author(s)
  浅井知浩、出羽毅久、奥直人
- Journal Title
  
  オレオサイエンス
  
  Volume: 16 Pages: 271-278
- NAID
  130007586963
- Data Source
  KAKENHI-PROJECT-16K08201
[Journal Article] 脂質ナノ粒子を用いた核酸医薬デリバリー2016
- Author(s)
  岡本彩香、浅井知浩、奥直人
- Journal Title
  
  Drug Delivery System
  
  Volume: 31 Pages: 54-61
- NAID
  130005147216
- Data Source
  KAKENHI-PROJECT-16K08201
[Journal Article] Susceptibility of PTEN-positive metastatic tumors to small interfering RNA targeting the mammalian target of rapamycin2015
- Author(s)
  Hiroyuki Koide, Tomohiro Asai, Hiroki Kato, Norihito Yonenaga, Masafumi Yokota, Hidenori Ando, Takehisa Dewa, Mamoru Nango, Noriyuki Maeda, Naoto Oku
- Journal Title
  
  Nanomedicine
  
  Volume: 11 Pages: 185-194
- DOI
  10.1016/j.nano.2014.09.003
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26888014, KAKENHI-PROJECT-25460041
[Journal Article] Treatment of stroke with liposomal neuroprotective agents under cerebral ischemia conditions2015
- Author(s)
  Fukuta T, Ishii T, Asai T, Sato A, Kikuchi T, Shimizu K, Minamino T, Oku N.
- Journal Title
  
  Eur J Pharm Biopharm.
  
  Volume: 97 (Pt A) Pages: 1-7
- DOI
  10.1016/j.ejpb.2015.09.020
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-14J10730, KAKENHI-PROJECT-25460041
[Journal Article] Cell-penetrating peptide-conjugated lipid nanoparticles for siRNA delivery.2014
- Author(s)
  Asai T, Tsuzuku T, Takahashi S, Okamoto A, Dewa T, Nango M, Hyodo K, Ishihara H, Kikuchi H, Oku N
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 444 Pages: 599-604
- DOI
  10.1016/j.bbrc.2014.01.107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460041
[Journal Article] Antibody-modified lipid nanoparticles for selective delivery of siRNA to tumors expressing membrane-anchored form of HB-EGF.2014
- Author(s)
  Okamoto A, Asai T, Kato H, Shimizu K, Ando H, Minamino T, Mekada E, Oku N
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 449 Pages: 460-465
- DOI
  10.1016/j.bbrc.2014.05.043
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460041, KAKENHI-PROJECT-26250033
[Journal Article] Advanced cancer therapy by integrative antitumor actions via systemic administration of miR-499.2014
- Author(s)
  Ando H, Asai T, Koide H, Okamoto A, Maeda N, Tomita K, Dewa T, Minamino T, Oku N
- Journal Title
  
  J. Control. Release
  
  Volume: 181 Pages: 32-39
- DOI
  10.1016/j.jconrel.2014.02.019
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460041
[Journal Article] Neuroprotective effect of nobiletin on cerebral ischemia–reperfusion injury in transient middle cerebral artery-occluded rats2014
- Author(s)
  Yasuda N, Ishii T, Oyama D, Fukuta T, Agato Y, Sato A, Shimizu K, Asai T, Asakawa T, Kan T, Yamada S, Ohizumi Y, Oku N.
- Journal Title
  
  Brain Res.
  
  Volume: 1559 Pages: 46-54
- DOI
  10.1016/j.brainres.2014.02.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23249005, KAKENHI-PROJECT-25460041, KAKENHI-PUBLICLY-26102736
[Journal Article] Suppression in mice of immunosurveillance against PEGylated liposomes by encapsulated doxorubicin.2014
- Author(s)
  Yahuafai J, Asai T, Nakamura G, Fukuta T, Siripong P, Hyodo K, Ishihara H, Kikuchi H, Oku N
- Journal Title
  
  J Control. Release
  
  Volume: 192 Pages: 167-173
- DOI
  10.1016/j.jconrel.2014.07.010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-14J10730, KAKENHI-PROJECT-25460041
[Journal Article] Real-time trafficking of PEGylated liposomes in the rodent focal brain ischemia analyzed by positron emission tomography.2014
- Author(s)
  Fukuta T, Ishii T, Asai T, Nakamura G, Takeuchi Y, Sato A, Agato Y, Shimizu K, Asai S, Fukumoto D, Harada N, Tsukada H, Kawaguchi AT, Oku N
- Journal Title
  
  Allergol Int
  
  Volume: 38 Pages: 37-47
- DOI
  10.1111/aor.12350
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14J10730, KAKENHI-PROJECT-23249005, KAKENHI-PROJECT-24659049, KAKENHI-PROJECT-25460041, KAKENHI-PROJECT-25461167
[Journal Article] Use of positron emission tomography for real-time imaging of biodistribution of green tea catechin.2014
- Author(s)
  Kosuke Shimizu, Tomohiro Asakawa, Norihiro Harada, Dai Fukumoto, Hideo Tsukada, Tomohiro Asai, Shizuo Yamada, Toshiyuki Kan, and Naoto Oku
- Journal Title
  
  PLoS One.
  
  Volume: 9
- DOI
  10.1371/journal.pone.0085520
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390007, KAKENHI-PUBLICLY-24102525, KAKENHI-PROJECT-24790017, KAKENHI-PROJECT-25460041, KAKENHI-PUBLICLY-26102736
[Journal Article] Enhanced active targeting via cooperative binding of ligands on liposomes to target receptors.2013
- Author(s)
  Sugiyama T, Asai T, Nedachi YM, Katanasaka Y, Shimizu K, Maeda N, Oku N.
- Journal Title
  
  PLoS One.
  
  Volume: 8
- DOI
  10.1371/journal.pone.0067550
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659021, KAKENHI-PROJECT-25460041
[Journal Article] Suppression of immune response by antigen-modified liposomes encapsulating model agents: A novel strategy for the treatment of allergy2013
- Author(s)
  Ichikawa K, Asai T, Shimizu K, Yonezavva S, Urakami T, Miyauchi H, Kawashima H, Ishida T, Kiwada H, and Oku N
- Journal Title
  
  J. Control. Release
  
  Volume: Vol. 167 Pages: 284-289
- DOI
  10.1016/j.jconrel.2013.02.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390018, KAKENHI-PROJECT-24790047, KAKENHI-PROJECT-25460041
[Journal Article] Treatment of cerebral ischemia-reperfusion injury with PEGylated liposomes encapsulating FK5062013
- Author(s)
  Ishii T, Asai T, Oyama D, Agato Y, Yasuda N, Fukuta T, Shimizu K, Minamino T, Oku N.
- Journal Title
  
  FASEB Journal.
  
  Volume: 27 Pages: 1362-1370
- DOI
  10.1096/fj.12-221325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249005, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24790047, KAKENHI-PROJECT-25460041
[Journal Article] Liposomes and nanotechnology in drug development: focus on ocular targets.2013
- Author(s)
  M. Honda, T. Asai, N. Oku, Y. Araki, M. Tanaka, N. Ebihara
- Journal Title
  
  inetrnational journal of nanomedicine
  
  Volume: 8 Pages: 495-503
- DOI
  10.2147/ijn.s30725
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790045, KAKENHI-PROJECT-24592679
[Journal Article] Enhanced active targeting via cooperative binding of ligands on liposomes to target receptors2013
- Author(s)
  Sugiyama T, Asai T, Nedachi YM, Katanasaka Y, Shimizu K, Maeda N, Oku N
- Journal Title
  
  PLoS One
  
  Volume: 8
- Data Source
  KAKENHI-PROJECT-24659021
[Journal Article] Systemic delivery of small interfering RNA by use of targeted polycation liposomes for cancer therapy.2013
- Author(s)
  Kenjo E, Asai T, Yonenaga N, Ando H, Ishii T, Hatanaka K, Shimizu K, Urita Y, Dewa T, Nango M, Tsukada H, Oku N.
- Journal Title
  
  Biol Pharm Bull.
  
  Volume: 36 Pages: 287-291
- NAID
  130003361373
- Data Source
  KAKENHI-PROJECT-24659021
[Journal Article] Nanoparticles accumulate in ischemic core and penumbra region even when cerebral perfusion is reduced2013
- Author(s)
  Ishii T, Fukuta T, Agato Y, Oyama D, Yasuda N, Shimizu K, Kawaguchi AT, Asai T, Oku N.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 430 Pages: 1201-1205
- DOI
  10.1016/j.bbrc.2012.12.080
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249005, KAKENHI-PROJECT-24249086, KAKENHI-PROJECT-24790047, KAKENHI-PROJECT-25460041
[Journal Article] Liposomal Amiodarone Augments Anti-arrhythmic Effects and Reduces Hemodynamic Adverse Effects in an Ischemia/Reperfusion Rat Model2013
- Author(s)
  Takahama H, Shigematsu H, Asai T, Matsuzaki T, Sanada S, Fu HY, Okuda K, Yamato M, Asanuma H, Asano Y, Asakura M, Oku N, Komuro I, Kitakaze M, Minamino T.
- Journal Title
  
  Cardiovasc. Drugs Ther.
  
  Volume: 27 Pages: 125-132
- DOI
  10.1007/s10557-012-6437-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591093, KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24591097, KAKENHI-PROJECT-25460041
[Journal Article] Systemic delivery of small interfering RNA by use of targeted polycation liposomes for cancer therapy.2013
- Author(s)
  Kenjo E, Asai T, Yonenaga N, Ando H, Ishii T, Hatanaka K, Shimizu K, Urita U, Dewa T, Nango M, Tsukada H, Oku N
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 36 Pages: 287-291
- NAID
  130003361373
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460041
[Journal Article] Polycation liposomes as a vector for potential intracellular delivery of microRNA.2013
- Author(s)
  Ando H, Okamoto A, Yokota M, Asai T, Dewa T, Oku N
- Journal Title
  
  J. Gene Med.
  
  Volume: 15 Pages: 375-383
- DOI
  10.1002/jgm.2744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460041
[Journal Article] Development of a miR-92a delivery system for anti-angiogenesis-based cancer therapy2013
- Author(s)
  H. Ando, A. Okamoto, M. Yokota, K. Shimizu, T. Asai, T. Dewa, N. Oku
- Journal Title
  
  J. Gene Med.
  
  Volume: 15 Pages: 20-27
- DOI
  10.1002/jgm.2690
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790045, KAKENHI-PROJECT-24790047, KAKENHI-PROJECT-25460041, KAKENHI-PUBLICLY-23107713
[Journal Article] Amelioration of cerebral ischemia-reperfusion injurybased on liposomal drug delivery system with asialo-erythropoietin.2012
- Author(s)
  T.Ishii, T.Asai, D.Oyama, T.Fukuta, N.Yasuda, K.Shimizu, T.Minamino, N.Oku
- Journal Title
  
  J Control Release
  
  Volume: (In press) Pages: 81-7
- DOI
  10.1016/j.jconrel.2012.02.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J55523, KAKENHI-PROJECT-22790045, KAKENHI-PROJECT-23249005, KAKENHI-PROJECT-23659416, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24790047
[Journal Article] Design and synthesis of high-avidity tetravalent glycoclusters as probes for sambucus sieboldiana agglutinin and characterization of their binding properties.2012
- Author(s)
  Ogata, M., Yano, M., Umemura, S., Murata, T., Park, E.Y., Kobayashi, Y., Asai, T., Oku, N., Nakamura, N., Matsuo, I., Usui, T.
- Journal Title
  
  Bioconjug.Chem.
  
  Volume: 23 Pages: 97-105
- DOI
  10.1021/bc200440e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22780101, KAKENHI-PROJECT-22790045, KAKENHI-PROJECT-24780111
[Journal Article] siRNAデリバリーシステムのPET解析と核酸医薬品開発への応用2012
- Author(s)
  浅井知浩
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 132 Pages: 1159-1163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790045
[Journal Article] Ability of fibrinogen γ-derived dodecapeptides with different sequences to bind to rat platelets.2012
- Author(s)
  K. Tokutomi, T. Tagawa, M. Korenaga, M. Chiba, T. Asai, N. Watanabe, S. Takeoka, M. Handa, Y. Ikeda, N. Oku
- Journal Title
  
  Int J Pharm.
  
  Volume: 438 Pages: 296-301
- DOI
  10.1016/j.ijpharm.2012.09.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790045
[Journal Article] RGD-based active targeting of novel polycation liposomes bearing siRNA for cancer treatment2012
- Author(s)
  Yonenaga N, Kenjo E, Asai T,Tsuruta A, Shimizu K, Dewa T, Nango M, Oku N:
- Journal Title
  
  J. Cont. Release
  
  Volume: 160 Pages: 177-181
- DOI
  10.1016/j.jconrel.2011.10.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790045, KAKENHI-PROJECT-24790047, KAKENHI-PUBLICLY-23107713
[Journal Article] A single injection of liposomal asialo-erythropoietin improves motor function deficit caused by cerebral ischemia/reperfusion2012
- Author(s)
  T. Ishii, T. Asai, T. Fukuta, D. Oyama, N. Yasuda, Y. Agato, K. Shimizu, T. Minamino, N. Oku
- Journal Title
  
  Int J Pharm.
  
  Volume: 439 Pages: 269-274
- DOI
  10.1016/j.ijpharm.2012.09.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790045, KAKENHI-PROJECT-23249005, KAKENHI-PROJECT-24790047
[Journal Article] Nanoparticle-mediated delivery of anticancer agents to tumor angiogenic vessels.2012
- Author(s)
  Asai T
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 35 Pages: 1855-1861
- NAID
  130001872277
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790045
[Journal Article] Development of anti-HB-EGF immunoliposomes for the treatment of breast cancer2012
- Author(s)
  K. Nishikawa, T. Asai, H. Shigematsu, K. Shimizu, H. Kato, Y. Asano, S. Takashima, E. Mekada, N. Oku, T. Minamino
- Journal Title
  
  J Control Release
  
  Volume: 160 Pages: 274-280
- DOI
  10.1016/j.jconrel.2011.10.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790045, KAKENHI-PROJECT-22890104, KAKENHI-PROJECT-23240126, KAKENHI-PROJECT-23659416, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24790047
[Journal Article] Size-dependent induction of accelerated blood clearance phenomenon by repeated injections of polymeric micelles.2012
- Author(s)
  H. Koide, T. Asai, H. Ando, K. Shiraishi,M. Yokoyama, and N. Oku
- Journal Title
  
  Int J Pharm.
  
  Volume: 432 Pages: 75-79
- DOI
  10.1016/j.ijpharm.2012.04.049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300170, KAKENHI-PROJECT-22790045, KAKENHI-PROJECT-24659021
[Journal Article] Size-dependent induction of accelerated blood clearance phenomenon by repeated injections of polymeric micelles2012
- Author(s)
  Koide H, Asai T, Kato H, Ando H, Shiraishi K,Yokoyama M, Oku N
- Journal Title
  
  Int J Pharm
  
  Volume: 432 Pages: 75-79
- Data Source
  KAKENHI-PROJECT-24659021
[Journal Article] Dicetyl phosphate-tetraethylenepentamine-based liposomes for systemic siRNA delivery.2011
- Author(s)
  T. Asai, S. Matsushita, E. Kenjo, T. Tsuzuku, N. Yonenaga, H. Koide, K. Hatanaka, T. Dewa, M. Nango, N. Maeda, H. Kikuchi, N. Oku
- Journal Title
  
  Bioconjug. Chem.
  
  Volume: 22 Pages: 429-435
- DOI
  10.1021/bc1004697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790045
[Journal Article] Dicetyl phosphate-tetraetylenepentamine-based liposomes for systemic siRNA Delivery2011
- Author(s)
  Tomohiro Asai, et al
- Journal Title
  
  Bioconjug.Chem.
  
  Volume: 22 Pages: 429-435
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659010
[Journal Article] Dicetyl phosphate -tetraethylenepentamine -based liposomes for systemic siRNA delivery2011
- Author(s)
  Asai, T., et al.
- Journal Title
  
  Bioconjug.Chem.
  
  Volume: 22 Pages: 429-435
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790045
[Journal Article] T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes.2010
- Author(s)
  Koide, H., Asai, T., Hatanaka, K., et al.
- Journal Title
  
  Int. J. Pharm. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790131
[Journal Article] Development of double-stranded siRNA labeling method using positron emitter and its in vivo trafficking analyzed by positron emission tomography.2010
- Author(s)
  Hatanaka, K., Asai, T., Koide, H., et al.
- Journal Title
  
  Bioconjug. Chem. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790131
[Journal Article] T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes.2010
- Author(s)
  Hiroyuki Koide, Tomohiro Asai, Kentaro Hatanaka, Shuji Akai, Takayuki Ishii, Eriya Kenjo, Tatsuhiro Ishida, Hiroshi Kiwada, Hideo Tsukada, Naoto Oku
- Journal Title
  
  Int.J. of Pharmaceutics 392
  
  Pages: 218-223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390014
[Journal Article] PET imaging of brain cancer with positron emitter-labeled liposomes2010
- Author(s)
  Naoto Oku, Mina Yamashita, Yurie Katayama, Takeo Urakami, Kentaro Hatanaka, Kosuke Shimizu, Tomohiro Asai, Hideo Tsukada, Shuji Akai, Hiroaki Kanazawa
- Journal Title
  
  Int. J. Pharm
  
  Volume: 403 Pages: 170-177
- Data Source
  KAKENHI-PROJECT-22659010
[Journal Article] Accumulation of macromolecules in brain parenchyma in acute phase of cerebral infarction/reperfusion.2010
- Author(s)
  Ishii, T., Asai, T., Urakami, T., et al.
- Journal Title
  
  Brain Res. 1321(in press)
  
  Pages: 164-168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790131
[Journal Article] Accumulation of macromolecules in brain parenchyma in acute phase of cerebral infarction/reperfusion2010
- Author(s)
  Takayuki Ishii, Tomohiro Asai, Takeo Urakami, Naoto Oku
- Journal Title
  
  Brain Res
  
  Volume: 1321 Pages: 164-168
- Data Source
  KAKENHI-PROJECT-22659010
[Journal Article] novel DDS strategy, "dual-targeting", and its application for antineovascular therapy.2010
- Author(s)
  Murase, Y., Asai, T., Katanasaka, Y., et al.
- Journal Title
  
  Cancer Lett. 287
  
  Pages: 165-171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790131
[Journal Article] In vivo distribution of liposome-encapsulated hemoglobin determined by positron emission tomography.2009
- Author(s)
  Urakami, T., Kawaguchi, A.T., Akai, S., (3), Asai, T., (4)
- Journal Title
  
  Artif. Organs 33
  
  Pages: 164-168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790131
[Journal Article] PEG化ナノキャリア頻回投与によるaccelerated blood clearance現象の機構解明2009
- Author(s)
  小出裕之、浅井知浩、畑中剣太朗、清水広介、横山昌幸、石田竜弘、際田弘志、奥直人
- Journal Title
  
  YAKUGAKU ZASSHI 129
  
  Pages: 1445-1451
- NAID
  130000136135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390014
[Journal Article] Evaluation of O-[(18)F] fluoromethyl-D-tyrosine as a radiotracer for tumor imaging with positron emission tomography.2009
- Author(s)
  Urakami, T., Sakai, K., Asai, T., et al.
- Journal Title
  
  Nucl. Med. Biol. 36
  
  Pages: 295-303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790131
[Journal Article] Prolonged targeting of ischemic/reperfused myocardium by liposomal adenosine augments cardioprotection in rats.2009
- Author(s)
  Takahama, H., Minamino, T., Asanuma, H., (1), Asai, T., (12)
- Journal Title
  
  J. Am. Coll. Cardiol. 53
  
  Pages: 709-717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790131
[Journal Article] Antineovascular therapy with angiogenic vessel-targeted polyethyleneglycol-shielded liposomal DPP-CNDAC.2008
- Author(s)
  Asai, T., Miyazawa, S., Maeda, N., et al.
- Journal Title
  
  Cancer Sci. 99
  
  Pages: 1029-1033
- NAID
  10024006453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790131
[Journal Article] Disappearance of the angiogenic potential of endothelial cells caused by Argonaute2 knockdown2008
- Author(s)
  Asai, T., et. al.
- Journal Title
  
  Biochem.Biophys.Res.Commun 368
  
  Pages: 243-248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790131
[Journal Article] Disappearance of the angiogenic potential of endothelial cells caused by Argonaute2 knockdown.2008
- Author(s)
  Asai, T., Suzuki, Y., Matsushita, S., et al.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 368
  
  Pages: 243-248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790131
[Journal Article] Particle size-dependent triggering of accelerated blood clearance phenomenon.2008
- Author(s)
  Hiroyuki Koide, Tomohiro Asai, Kentaro Hatanaka, Takeo Urakami, Takayuki Ishii, Eriya Kenjo, Masamichi Nishihara, Masayuki Yokoyama, Tatsuhiro Ishida, Hiroshi Kiwada, Naoto Oku
- Journal Title
  
  Int.J.Pharm 362
  
  Pages: 197-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390014
[Journal Article] Antineovascular therapy with angiogenic vessel-targeted polyethyleneglycol-shielded Aliposomal DPP-CNDAC2008
- Author(s)
  Asai, T., et. al.
- Journal Title
  
  Cancer Sci 99
  
  Pages: 1029-1033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790131
[Journal Article] Particle size-dependent triggering of accelerated blood clearance phenomenon.2008
- Author(s)
  Koide, H., Asai, T., Hatanaka, K., et al.
- Journal Title
  
  Int. J. Pharm. 362
  
  Pages: 197-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790131
[Journal Article] Disappearance of the angiogenic potential of endothelial cells caused by Argonaute2 knockdown2008
- Author(s)
  Asai, T
- Journal Title
  
  Biochem. Biophys. Res. Commun 368
  
  Pages: 243-248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015039
[Journal Article] Disappearance of the angiogenic potential of endothelial cells caused by Argonaute2 knockdown.2008
- Author(s)
  Asai, T.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 368
  
  Pages: 243-248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390014
[Journal Article] Antineovascular therapy with angiogenic vesseltargeted polyethyleneglycol shielded linosomal DPPCNDAC2008
- Author(s)
  Asai, T
- Journal Title
  
  Cancer Sci 99
  
  Pages: 1029-1033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015039
[Journal Article] Effective tumor regression by antineovascular therapy in hypovascular orthotopic pancreatic tumor model2007
- Author(s)
  S. Yonezawa, T. Asai, N. Oku
- Journal Title
  
  J. Control 118Release
  
  Pages: 303-309
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390052
[Journal Article] 腫瘍新生血管標的化リボソーム2007
- Author(s)
  浅井知浩, ら
- Journal Title
  
  Mebio Oncology 4
  
  Pages: 48-57
- Data Source
  KAKENHI-PROJECT-19790131
[Journal Article] リポソーム応用の新展開.2006
- Author(s)
  浅井知浩ら
- Journal Title
  
  最新医学 61
  
  Pages: 1084-1091
- Data Source
  KAKENHI-PROJECT-17790128
[Journal Article] Antineovasucular therapy, a novel antiangiogenic approach.2005
- Author(s)
  K.Shimizu, T.Asai, N.Oku
- Journal Title
  
  Expert Opin.Ther.Targets 9
  
  Pages: 63-76
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390050
[Journal Article] Applicability of anti-neovascular therapy to drug-resistant tumor : Suppression of drug-resistant P388 tumor growth with neovessel-targeted liposomal adriamycin.2005
- Author(s)
  K.Shimizu, T.Asai, N.Oku, et al.
- Journal Title
  
  Int.J.Pharm. 296
  
  Pages: 133-141
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390050
[Journal Article] 腫瘍新生血管標的化リポソームの新展開2005
- Author(s)
  浅井知浩
- Journal Title
  
  薬剤学 65
  
  Pages: 169-174
- NAID
  10016674615
- Data Source
  KAKENHI-PROJECT-17790128
[Journal Article] Anti- neovasucular therapy by liposomal drug targeted to membrane type-1 matrix metalloproteinase.2004
- Author(s)
  M.Kondo, T.Asai, N.Oku, et al.
- Journal Title
  
  Int. J. Cancer 108
  
  Pages: 301-306
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390050
[Presentation] ピペラジン骨格を有する新規機能性脂質の開発2022
- Author(s)
  朝山紗衣、横内綾乃、井上雄希、冨田康治、前田典之、奥直人、浅井知浩
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] セラミド骨格を有する新規チャージリバーシブル脂質の開発2022
- Author(s)
  横内綾乃、朝山紗衣、井上雄希、冨田康治、前田典之、奥直人、浅井知浩
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] ピペラジン骨格を有する新規機能性脂質の開発2021
- Author(s)
  横内綾乃、冨田康治、井上雄希、前田典之、奥　直人、浅井知浩
- Organizer
  日本核酸医薬学会第6回年会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] 生体内で標的毒素を中和するポリマー結合PEG修飾リポソームの開発2021
- Author(s)
  岡本卓巳、小出裕之、山内郁実、星野　友、奥　直人、浅井知浩
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 自己抗原修飾リポソームによる自己抗原認識免疫細胞への標的化と自己免疫疾患治療2021
- Author(s)
  清水広介、高杉昇平、阿形寿規、成田雄大、浅井知浩、奥直人、間賀田泰寛
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] 生体内で標的毒素を中和するポリマー結合PEG修飾リポソームの開発2021
- Author(s)
  岡本卓巳、小出裕之、山内郁実、星野　友、奥　直人、浅井知浩
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] タンパク質の細胞内送達に向けたDDS技術の開発2021
- Author(s)
  平田真也、小出裕之、落合広樹、鈴木ひかる、出羽毅久、奥　直人、浅井知浩
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] 温度に応答して標的ペプチドを吸着・放出する合成高分子ナノ粒子の開発とがん治療応用2021
- Author(s)
  小出裕之、齋藤和弘、星野友、Shea Kenneth、奥直人、浅井知浩
- Organizer
  第70回高分子討論会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] 多官能性ポリマーナノ粒子の敗血症治療への応用2021
- Author(s)
  小出裕之、星野　友、奥　直人、シェアケネス、浅井知浩
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] Design of synthetic polymer nanoparticle for sepsis therapy2021
- Author(s)
  Hiroyuki Koide, Yu Hoshino, Naoto Oku, Tomohiro Asai, Kenneth J,Shea
- Organizer
  Serendipity Symposium 2020
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] リポソーム製剤からの難溶性ペプチドの経口吸収挙動の解析2021
- Author(s)
  北村優花、南　景子、片岡　誠、高木敏英、浅井知浩、奥　直人、山下伸二
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] 凍結融解技術を駆使したリポソームによるタンパク質の細胞内送達2021
- Author(s)
  平田真也、小出裕之、落合広樹、鈴木ひかる、出羽毅久、奥　直人、浅井知浩
- Organizer
  第67回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] Synthetic polymer nanoparticles that release toxic peptides below lower critical solution temperature for cancer therapy2021
- Author(s)
  Hiroyuki Koide, Kazuhiro Saito, Keiichi Yoshimatsu, Yu Hoshino, Naoto Oku, Kenneth J. Shea, Tomohiro Asai
- Organizer
  Pacifichem 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] 生体内で標的毒素を中和するポリマーリガンド修飾リポソームの開発2021
- Author(s)
  山内郁実、小出裕之、星野友、奥直人、浅井知浩
- Organizer
  第65回高分子討論会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] ynthetic polymer nanoparticles that release toxic peptides below lower critical solution temperature for cancer therapy2021
- Author(s)
  Hiroyuki Koide, Kazuhiro Saito, Keiichi Yoshimatsu, Yu Hoshino, Naoto Oku, Kenneth J. Shea, Tomohiro Asai
- Organizer
  Pacifichem
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 合成高分子ナノ粒子の精製方法がその機能に及ぼす影響2021
- Author(s)
  安野豪、小出裕之、米澤正、浅井知浩
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] 温度に応答して標的分子を吸着・放出するナノゲル粒子の開発とがん治療応用2021
- Author(s)
  安野　豪、小出裕之、齊藤和弘、星野　友、シアケネス、奥　直人、米澤　正、浅井知浩
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] 温度に応答して標的分子を吸着・放出するナノゲル粒子の開発とがん治療応用2021
- Author(s)
  安野　豪、小出裕之、齊藤和弘、星野　友、シアケネス、奥　直人、米澤　正、浅井知浩
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 標的分子を吸着し中和する多官能性リポソームの開発2021
- Author(s)
  鈴木ひかる、小出裕之、平野覚士、井出貴文、濱島義隆、奥直人、浅井知浩
- Organizer
  第65回高分子討論会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 核酸デリバリー用新規pH応答性脂質誘導体の開発2021
- Author(s)
  冨田康治、横内綾乃、井上雄希、前田典之、奥　直人、浅井知浩
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] 糖尿病モデルラットを用いた尿細管指向性を有するペプチドの探索2021
- Author(s)
  林　純衣、米澤　正、小出裕之、浅井知浩
- Organizer
  第67回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] 凍結融解技術を駆使したリポソームによるタンパク質の細胞内送達2021
- Author(s)
  平田真也、小出裕之、落合広樹、鈴木ひかる、出羽毅久、奥　直人、浅井知浩
- Organizer
  第67回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] 核酸デリバリー用新規pH応答性脂質誘導体の開発2021
- Author(s)
  冨田康治、横内綾乃、井上雄希、前田典之、奥　直人、浅井知浩
- Organizer
  日本核酸医薬学会第6回年会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] 糖尿病モデルラット腎尿細管・間質領域に対する薬物送達システムの構築2021
- Author(s)
  米澤正、林純衣、小出裕之、川崎靖、杉山晶規、浅井知浩
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] 血栓標的化２剤内封リポソームの開発とがん治療応用2021
- Author(s)
  宋　復燃、森本誠士郎、山本裕和、小出裕之、米澤　正、浅井知浩
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] Design of a synthetic polymer nanoparticle that captures and neutralizes target molecules in the body2021
- Author(s)
  Hiroyuki Koide, Hoshino Yu, Oku Naoto, Shea Kenneth, Asai Tomohiro
- Organizer
  第65回高分子討論会日韓ジョイントシンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 温度に応答して標的分子を吸着・放出するナノゲル粒子を用いたがん治療研究2021
- Author(s)
  齋藤和弘、小出裕之、星野友、奥直人、浅井知浩
- Organizer
  第65回高分子討論会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] ピペラジン骨格を有する新規機能性脂質の開発2021
- Author(s)
  横内綾乃、冨田康治、井上雄希、前田典之、奥　直人、浅井知浩
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] 多官能性ポリマーナノ粒子の敗血症治療への応用2021
- Author(s)
  小出裕之、星野　友、奥　直人、シェアケネス、浅井知浩
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] 温度に応答して標的ペプチドを吸着・放出する合成高分子ナノ粒子の開発とがん治療応用2021
- Author(s)
  小出裕之、齋藤和弘、星野友、Shea Kenneth、奥直人、浅井知浩
- Organizer
  第70回高分子討論会
- Invited
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 自己抗原修飾リポソームによる自己抗原認識免疫細胞への標的化と自己免疫疾患治療2021
- Author(s)
  清水広介，高杉昇平，阿形寿規，成田雄大，浅井知浩，奥直人，間賀田泰寛
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06593
[Presentation] 凍結融解技術を用いたタンパク質内封リポソームの調製と細胞内送達2021
- Author(s)
  落合広樹、小出裕之、鈴木ひかる、出羽毅久、奥直人、浅井知浩
- Organizer
  第36回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 生体内で標的毒素を中和する多官能性リポソームの開発2021
- Author(s)
  丸橋春日、小出裕之、平野覚士、鈴木ひかる、落合広樹、江上寛道、濱島義隆、浅井知浩
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] 脂質パッケージングによる負電荷タンパク質の細胞内送達2021
- Author(s)
  平井勇祐、広瀬久昭、今西未来、浅井知浩、二木史朗
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] 腎疾患治療開発に向けた尿細管指向性薬物送達ツールの開発2021
- Author(s)
  林　純衣、米澤　正、小出裕之、浅井知浩
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] charge-reversible脂質を用いたsiRNA内封型脂質ナノ粒子の開発及び有用性評価2021
- Author(s)
  萩原佑哉、高井彩花、橋本正寛、宋復燃、米澤正、冨田康治、前田典之、浅井知浩
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] 標的分子を吸着してその機能を中和する合成高分子ナノ粒子「プラスチック抗体」開発2021
- Author(s)
  小出裕之、星野友、三浦佳子、シェアケネス、奥直人、浅井知浩
- Organizer
  日本薬剤学会第35年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 生体内で標的毒素を中和するポリマーリガンド修飾リポソームの開発2020
- Author(s)
  山内郁実、小出裕之、星野友、奥直人、浅井知浩
- Organizer
  第65回高分子討論会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] 凍結融解技術を用いたタンパク質内封リポソームの調製と細胞内送達2020
- Author(s)
  落合広樹、小出裕之、鈴木ひかる、出羽毅久、奥直人、浅井知浩
- Organizer
  第36回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] 標的分子を吸着し中和する多官能性リポソームの開発2020
- Author(s)
  鈴木ひかる、小出裕之、平野覚士、井出貴文、濱島義隆、奥直人、浅井知浩
- Organizer
  第65回高分子討論会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] ピペラジン骨格を有する新規機能性脂質の開発2020
- Author(s)
  冨田康治、井上雄希、深田尚文、前田典之、奥直人、浅井知浩
- Organizer
  第36回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] 血栓集積性リポソームを用いた脳梗塞セラノスティクス製剤の開発2020
- Author(s)
  柳田洋翼、山本裕和、小出裕之、米澤正、浅井知浩
- Organizer
  第36回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] 温度に応答して標的分子を吸着・放出するナノゲル粒子を用いたがん治療研究2020
- Author(s)
  齋藤和弘、小出裕之、星野友、奥直人、浅井知浩
- Organizer
  第65回高分子討論会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] Design of synthetic polymer nanoparticle for sepsis therapy2020
- Author(s)
  Hiroyuki Koide, Yu Hoshino, Naoto Oku, Tomohiro Asai, Kenneth J,Shea
- Organizer
  Serendipity Symposium 2020
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] 自己抗原認識免疫細胞を標的とする多発性硬化症治療薬の開発2020
- Author(s)
  清水広介，高杉昇平，阿形寿規，成田雄大，浅井知浩，奥直人，間賀田泰寛
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-18K06593
[Presentation] 標的分子を吸着してその機能を中和する合成高分子ナノ粒子「プラスチック抗体」開発2020
- Author(s)
  小出裕之、星野友、三浦佳子、シェアケネス、奥直人、浅井知浩
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] 多発性硬化症治療に向けた自己抗原修飾リポソーム製剤の開発2020
- Author(s)
  清水広介，高杉昇平，阿形寿規，成田雄大，浅井知浩，奥直人，間賀田泰寛
- Organizer
  第32回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06593
[Presentation] Design of a synthetic polymer nanoparticle that captures and neutralizes target molecules in the body2020
- Author(s)
  Hiroyuki Koide, Hoshino Yu, Oku Naoto, Shea Kenneth, Asai Tomohiro
- Organizer
  第65回高分子討論会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] 難溶性薬物の消化管吸収改善を目指したリポソーム製剤の検討2020
- Author(s)
  吉川叶恵、南景子、東野晴輝、片岡誠、浅井知浩、奥直人、山下伸二
- Organizer
  第36回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-20K21905
[Presentation] Development of polymer nanoparticles adsorbing α-glucosidase for diabetes treatment2019
- Author(s)
  Ayaka Masuda, Hiroyuki Koide, Hiromichi Egami,Yoshitaka Hamashima, Naoto Oku, Tomohiro asai
- Organizer
  ACS meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 敗血症治療に向けた多官能性ポリマーナノ粒子の開発2019
- Author(s)
  小出裕之、星野友、 Shea Kenneth J.、奥直人、浅井知浩
- Organizer
  第29回バイオ・高分子シンポジウム
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 自己抗原修飾リポソームを用いた自己免疫疾患治療の機構解析2019
- Author(s)
  髙杉昇平、清水広介、阿形寿規、成田雄大、間賀田泰寛、奥直人、浅井知浩
- Organizer
  第35回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06593
[Presentation] Development of a plastic antibody that captures vascular endothelial growth factor (VEGF) for anticancer therapy2019
- Author(s)
  Hiroyuki Koide, Yu Hoshino, Yuri Noshimura, Yoshiko Miura, Naoto Oku, and Kenneth J Shea, Tomohiro Asai
- Organizer
  ACS meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 自己抗原修飾リポソームを用いた実験的自己免疫性脳脊髄炎治療2019
- Author(s)
  髙杉昇平、清水広介、阿形寿規、成田雄大、奥直人、浅井知浩
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K06593
[Presentation] Design of multi-functionalized liposome for adsorbing and neutralizing target molecules in vivo2019
- Author(s)
  Satoshi Hirano, Hiroyuki Koide, Takahumi Ide, Yoshitaka Hamashima, Naoto Oku, Tomohiro Asai
- Organizer
  ACS meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] ペプチドを可逆的に吸着・放出する温度応答性ナノゲル粒子の生体内応用2019
- Author(s)
  齋藤和弘、小出裕之、星野友、奥直人、浅井知浩
- Organizer
  第29回バイオ・高分子シンポジウム
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 自己抗原修飾リポソームを用いた標的化DDSによる自己免疫疾患治療2019
- Author(s)
  清水広介、高杉昇平、阿形寿規、成田雄大、浅井知浩、奥直人、間賀田泰寛
- Organizer
  第35回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06593
[Presentation] タンパク質の細胞内送達を可能にする多官能性リポソームの開発2019
- Author(s)
  鈴木ひかる、小出裕之、菱木麻美、江上寛通、橋本博、濱島　義隆、出羽毅久、奥直人、浅井知浩
- Organizer
  日本薬剤学会第34年会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 温度に応答してペプチドを吸着・放出するナノゲル粒子の生体内利用に向けた検討2019
- Author(s)
  齋藤和弘、小出裕之、星野友、Shea Kenneth J.、奥直人、浅井知浩
- Organizer
  第35回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 自己抗原認識免疫細胞への標的化DDSと多発性硬化症治療応用2019
- Author(s)
  清水広介、高杉昇平、阿形寿規、成田雄大、浅井知浩、奥直人、間賀田泰寛
- Organizer
  第31回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06593
[Presentation] Autoantigen-modified liposomes as an immune cell-targetable drug carrier for the treatment of multiple sclerosis2019
- Author(s)
  Shohei Takasugi, Kazuki Agata, Naoto Oku, Tomohiro Asai, Kosuke Shimizu
- Organizer
  Liposome Research Days 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06593
[Presentation] 敗血症治療に向けた合成高分子ナノ粒子の開発2019
- Author(s)
  小出裕之、星野友、奥直人、浅井知浩
- Organizer
  第 65 回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 生体内で標的毒素を中和するポリマー修飾リポソームの開発2019
- Author(s)
  山内郁実、小出裕之、星野友、奥直人、浅井知浩
- Organizer
  日本薬剤学会第34年会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] Development of autoantigen-modified liposomes for the treatment of autoimmune diseases2019
- Author(s)
  Shohei Takasugi, Kazuki Agata, Yudai Narita, Naoto Oku, Tomohiro Asai, Kosuke Shimizu
- Organizer
  CRS2019 Annual Meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06593
[Presentation] マイクロ流路を用いたcharge-reversible脂質ナノ粒子調製法の構築2018
- Author(s)
  佐伯椋子、平井勇祐、豊田敬康、小出裕之、奥　直人、深田尚文、富田康治、前田典之、浅井知浩
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] Charge-reversible 脂質ナノ粒子を用いたin vivo における遺伝子サイレンシング2018
- Author(s)
  平井勇祐、佐伯椋子、岡本彩香、奥直人、深田尚文、冨田康治、前田典之、浅井知浩
- Organizer
  第34回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] Charge-reversible脂質を用いたsiRNAデリバリーシステムの開発と有用性評価2018
- Author(s)
  平井勇祐、佐伯椋子、岡本彩香、浅井知浩、深田尚文、冨田康治、前田典之、奥　直人
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] 実験計画法を用いたcharge-reversible脂質ナノ粒子調製法の構築2018
- Author(s)
  佐伯椋子、平井勇介、豊田敬康、小出裕之、奥直人、深田尚文、冨田康治、前田典之、浅井知浩
- Organizer
  日本核酸医薬学会第4回年会
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] フッ素導入によるポリアミンリポソームの精密なpKa制御とsiRNA送達効率に与える影響評価2018
- Author(s)
  岡本彩香、小出裕之、森田直樹、濱島義隆、浅井知浩、奥　直人
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] Establishment of a preparation method for charge-reversible LNP by use of “Design of Experiment”2018
- Author(s)
  Ryoko Saeki, Yusuke Hirai, Hiroyasu Toyota, Hiroyuki Koide, Naoto Oku, Naofumi Fukata, Koji Tomita, Noriyuki Maeda, Tomohiro Asai
- Organizer
  NANODDS 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] DOP-DETA-based novel polycation liposomes for systemic delivery of siRNA2018
- Author(s)
  Furan Song, Hiroyuki Koide, Naoto Oku, Takehisa Dewa, Tomohiro Asai
- Organizer
  NANODDS 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] 脳梗塞モデルラットを用いた血栓溶解療法におけるFasudil-Lipの脳保護効果の解析2018
- Author(s)
  山本裕和、柳田洋翼、奥　直人、浅井知浩
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] マイクロ流路を用いたcharge-reversible脂質ナノ粒子調製法の構築2018
- Author(s)
  佐伯椋子、平井勇祐、浅井知浩、深田尚文、冨田康治、前田典之、奥　直人
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] charge-reversible 脂質を用いた siRNA 内封型脂質ナノ粒子の開発2018
- Author(s)
  平井勇祐、小出裕之、奥直人、深田尚文、冨田康治、前田典之、浅井知浩
- Organizer
  第40回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] Charge-reversible脂質を用いたsiRNA内封型脂質ナノ粒子の調製とRNA干渉誘導能評価2018
- Author(s)
  平井勇祐、佐伯椋子、岡本彩香、奥　直人、深田尚文、冨田康治、前田典之、浅井知浩
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] Controlling the particle size of charge-reversible LNP using“Design of Experiment”2018
- Author(s)
  Ryoko Saeki, Yusuke Hirai, Hiroyasu Toyota, Hiroyuki Koide, Naoto Oku, Naofumi Fukata, Koji Tomita, Noriyuki Maeda and Tomohiro Asai
- Organizer
  Vancouver Nanomedicine Day 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] リポソームDDSを用いた新規がん化学療法の開発2018
- Author(s)
  浅井知浩
- Organizer
  日本薬学会東海支部合同学術大会2018
- Invited
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] リポソーム製剤の薬効における薬物放出性の影響2018
- Author(s)
  浅井知浩、奥直人
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] 脳虚血再灌流障害治療へ向けた HMGB-1 結合ポリマーナノ粒子の設計2018
- Author(s)
  沖嶋杏奈，小出裕之，清川千秋，星野友，三浦佳子，Kenneth J. SHEA，奥直人，浅井知浩
- Organizer
  日本薬学会東海支部合同学術大会2018
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] 新規ポリカチオンリポソームを用いたRNA干渉誘導の機構解明2017
- Author(s)
  迫真理子、浅井知浩、出羽毅久、奥直人
- Organizer
  第39回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] 核酸デリバリーを目的とした脂質ナノ粒子の設計戦略2017
- Author(s)
  浅井知浩、奥直人
- Organizer
  日本核酸医薬学会第3回年会
- Invited
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] ヒト乳がん移植モデルにおける抗体修飾脂質ナノ粒子を用いたsiRNA送達の有用性評価2017
- Author(s)
  岡本彩香、平井勇祐、浅井知浩、南野哲男、奥直人
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] Treatment of ischemic stroke by combination therapy with liposomal neuroprotectants plus tissue plasminogen activator2017
- Author(s)
  Tatsuya Fukuta, Yosuke Yanagida, Tomohiro Asai, Naoto Oku
- Organizer
  The 12th China-Japan Symposium on Health Sciences
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] 凍結融解技術を利用した新規siRNA封入方法の開発2017
- Author(s)
  清水晃介、小出裕之、岡本彩香、出羽毅久、浅井知浩、奥直人
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] Treatment of ischemic stroke by combination therapy with liposomal neuroprotectants plus tissue plasminogen activator2017
- Author(s)
  Tatsuya Fukuta, Yosuke Yanagida, Tomohiro Asai, Naoto Oku:
- Organizer
  The 12th China-Japan Symposium on Health Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] RNA干渉のがん治療応用を目指したsiRNA封入脂質ナノ粒子の有効性検討2017
- Author(s)
  岡本彩香、浅井知浩、奥直人
- Organizer
  日本薬剤学会第32年会
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] フッ素導入ポリアミン脂質を用いたリポソームの精密なpKa制御とRNA干渉効果への影響2017
- Author(s)
  岡本彩香、小出裕之、浅井知浩、森田直樹、濱島義隆、奥直人
- Organizer
  日本核酸医薬学会第3回年会
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] Combination therapy of cancer with possible RNAi enhancer and siRNA targeting polo-like kinase12017
- Author(s)
  Masahiro Hashimoto, Tomohiro Asai, Naoto Oku, Takehisa Dewa
- Organizer
  The 19th Takeda Science Foundation Symposium on Bioscience
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] リポソームDDS製剤と血栓融解剤併用による新規脳梗塞治療法の開発2017
- Author(s)
  福田達也、浅井知浩、奥直人
- Organizer
  第26回DDSカンファランス
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] Elucidation of the mechanism for highly efficient RNAi with low concentration of siRNA using novel polycation liposomes2017
- Author(s)
  Mariko Sako, Tomohiro Asai, Takehisa Dewa, Naoto Oku
- Organizer
  ILS and LRD Combined Conference 2017
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] Usefulness of liposomal neuro-protectants for the treatment of ischemic stroke2017
- Author(s)
  Naoto Oku, Tatsuya Fukuta, Hiroyuki Koide, Kosuke Shimizu, Tomohiro Asai
- Organizer
  Liposome Advances Progress in Drug and Vaccine Delivery
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] リポソーム化脳保護薬と血栓溶解剤の併用による脳梗塞治療2017
- Author(s)
  福田達也、柳田洋翼、浅井知浩、奥直人
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] Systemic delivery of siRNA for cancer treatment with anti-HB-EGF antibody-modified lipid nanoparticles2017
- Author(s)
  Ayaka Okamoto, Tomohiro Asai, Yusuke Hirai, Tetsuo Minamino, Naoto Oku
- Organizer
  ILS and LRD Combined Conference 2017
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] Combination therapy with liposomal fasudil and tissue plasminogen activator for ischemic stroke treatment2017
- Author(s)
  Yosuke Yanagida, Tatsuya Fukuta, Tomohiro Asai, Kosuke Shimizu, Hiroyuki Koide, Naoto Oku:
- Organizer
  Liposomes Advances Progress in Drug and Vaccine Delivery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] Development of antibody-modified lipid nanoparticles encapsulating siRNA for the treatment of cancer2017
- Author(s)
  Ayaka Okamoto, Tomohiro Asai, Tetsuo Minamino, Naoto Oku
- Organizer
  The 12th China-Japan Symposium on Health Sciences
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] siRNAの全身送達を目的としたDOP-DETA脂質ナノ粒子の開発2017
- Author(s)
  宋復燃、李嬌、浅井知浩、出羽毅久、奥直人
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] Combination treatment of cancer cells with verteporfin and siRNA targeting polo-like kinase 12017
- Author(s)
  Masahiko Hashimoto, Tomohiro Asai, Naoto Oku
- Organizer
  The 12th China-Japan Symposium on Health Sciences
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] Combination treatment of human breast cancer cells with a possible RNAi enhancer and siRNA targeting polo-like kinase12017
- Author(s)
  Naoyuki Sakurai, Masahiro Hashimoto, Tomohiro Asai, Dewa Takehisa, Naoto Oku
- Organizer
  ILS and LRD Combined Conference 2017
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] Charge-reversible脂質を用いたsiRNAデリバリーシステムの開発2017
- Author(s)
  平井勇祐、浅井知浩、岡本彩香、深田尚文、冨田康治、前田典之、奥直人
- Organizer
  日本核酸医薬学会第3回年会
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] 新規ポリカチオンリポソームを用いた低濃度siRNAによるRNA干渉の機構解明2017
- Author(s)
  迫真理子、浅井知浩、出羽毅久、奥直人
- Organizer
  日本核酸医薬学会第3回年会
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] リポソーム化脳保護薬と血栓溶解剤の併用による脳梗塞治療2017
- Author(s)
  福田達也、柳田洋翼、浅井知浩、奥直人
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] Development of DOP-DETA-based lipid nanoparticles for systemic delivery of siRNA2017
- Author(s)
  Furan Song, Tomohiro Asai, Takehisa Dewa, Naoto Oku
- Organizer
  ILS and LRD Combined Conference 2017
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] 脳保護薬内封リポソームと血栓溶解剤併用による脳梗塞治療2016
- Author(s)
  福田達也、柳田洋翼、浅井知浩、奥直人
- Organizer
  日本薬剤学会第31年会
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] Multifunctional polymer-modified liposomes that capture and neutralize toxic protein, histones.2016
- Author(s)
  48.Hiroki Tsuchida, Hiroyuki Koide, Masahiko Nakamoto, Anna Okishima, Saki Ariizumi, Chiaki Kiyokawa, Tomohiro Asai, Yu Hoshino, Naoto Oku
- Organizer
  International Conference on Nanomedicine and Nanobiotechnoloty
- Place of Presentation
  Paris, France
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-16K15111
[Presentation] RNA干渉の増強とPIK1を標的としたsiRNAによるがん併用療法2016
- Author(s)
  橋本正寛、浅井知浩、奥直人
- Organizer
  第25回DDSカンファランス
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] Combination therapy with liposomal neuroprotective agents plus tissue plasminogen activator for the treatment of ischemic stroke.2016
- Author(s)
  Tatsuya Fukuta, Yosuke Yanagida, Tomohiro Asai, Naoto Oku
- Organizer
  2016 AAPS Annual Meeting and Exposition
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] PTEN変異に基づく合成致死性を利用したRNA干渉療法2016
- Author(s)
  櫻井尚之、磯村秀樹、横田将史、小出裕之、浅井知浩、出羽毅久、奥直人
- Organizer
  第80回日本生化学会中部支部例会・シンポジウム
- Place of Presentation
  三重
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] in vivoイメージングによるナノDDS製剤の評価2016
- Author(s)
  浅井知浩、奥直人
- Organizer
  第25回日本バイオイメージング学会
- Place of Presentation
  名古屋
- Invited
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] A novel liposome vector for cancer treatment with RNA interference2016
- Author(s)
  Furan Song, Jiao Li, Tomohiro Asai, Takehisa Dewa, Naoto Oku
- Organizer
  第21回静岡健康・長寿学術フォーラム
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] PCL/siRNA複合体の凍結融解による簡便なsiRNAの内封方法の開発2016
- Author(s)
  小出裕之、岡本彩香、出羽毅久、浅井知浩、奥直人
- Organizer
  第80回日本生化学会中部支部例会・シンポジウム
- Place of Presentation
  三重
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] Simple and efficient approach for siRNA encapsulation into PCLs by freeze-thawing method.2016
- Author(s)
  Ayaka Okamoto, Hiroyuki Koide, Hiroki Tsuchida, Hidenori Ando, Saki Ariizumi, Chiaki Kiyokawa, Masahiro Hashimoto, Tomohiro Asai, Takehisa Dewa, Naoto Oku
- Organizer
  International Conference on Nanomedicine and Nanobiotechnology
- Place of Presentation
  Paris, France
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] Excellent gene silencing with DOP-DETA-based lipid nanoparticles loaded with siRNA2016
- Author(s)
  Ayaka Okamoto, Mariko Sako, Jiao Li, Tomohiro Asai, Takehisa Dewa, Naoto Oku
- Organizer
  The 1st Workshop for Japan-Korea Yong Scientists on Pharmaceutics
- Place of Presentation
  京都
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] Combination treatment of human breast cancer cells with possible RNAi enhancer and siRNA targeting polo-like kinase 12016
- Author(s)
  Masahiro Hashimoto, Tomohiro Asai, Naoto Oku
- Organizer
  2016 AAPS Annual Meeting and Exposition
- Place of Presentation
  Denver, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] Efficient gene silencing with siRNA formulated in DOP-DETA-based lipid nanoparticles.2016
- Author(s)
  Tomohiro Asai, Mariko Sako, Jiao Li, Ayaka Okamoto, Takehisa Dewa, Naoto Oku
- Organizer
  International Conference on Nanomedicine and Nanobiotechnology
- Place of Presentation
  Paris, France
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08201
[Presentation] Mitochondrial Complex-1活性のPET解析によるDDS製剤の脳保護効果評価2016
- Author(s)
  福田達也、浅井知浩、原田典弘、塚田秀夫、奥直人
- Organizer
  第16回放射性医薬品・画像診断薬研究会
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] 生体内で標的毒素を中和するポリマーリガンド修飾脂質ナノ粒子の開発2016
- Author(s)
  59.土田大貴、小出裕之、仲本正彦、沖嶋杏奈、有泉早紀、清川千秋、浅井知浩、星野友、奥直人
- Organizer
  第38回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-16K15111
[Presentation] 脳虚血再灌流障害モデルにおけるリポソーム化Fasudilの脳内挙動解析と治療効果2016
- Author(s)
  柳田洋翼、福田達也、南場美緒、浅井知浩、奥直人
- Organizer
  日本薬剤学会第31年会
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] Synthetic lethality-based therapy for PTEN-deficient cancer by silencing of PARP1 gene2015
- Author(s)
  Hideki Isomura, Yokota Masafumi, Tomohiro Asai, Kosuke Shimizu, Takehisa Dewa, Naoto Oku
- Organizer
  13th US-Japan Symposium on Drug Delivery Systems
- Place of Presentation
  Maui, USA
- Year and Date
  2015-12-18
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] 新規ポリアミン脂質誘導体を用いたsiRNAベクターの開発2015
- Author(s)
  浅井知浩、岡本彩香、李嬌、宋復燃、出羽毅久、奥直人
- Organizer
  第37回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  熊本
- Year and Date
  2015-11-20
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] miR-499血管正常化作用による抗がん剤の薬効増強2015
- Author(s)
  58.Sho Ryu, Hidenori Ando,劉暁、安藤英紀、前田典之、浅井知浩、出羽毅久、奥直人
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-26670018
[Presentation] siRNA内封脂質ナノ粒子を用いたPLK1ノックダウンによるがん治療法の開発2015
- Author(s)
  岡本彩香、岡田憲明、浅井知浩、南野哲男、目加田英輔、奥直人
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] リポソームDDSを用いた脳梗塞治療法の開発2015
- Author(s)
  浅井知浩、福田達也、奥直人
- Organizer
  第31回日本DDS学会学術集会
- Place of Presentation
  東京
- Year and Date
  2015-07-03
- Invited
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] 抗体修飾脂質ナノ粒子を用いた腫瘍選択的siRNA送達技術の開発2015
- Author(s)
  岡本彩香、岡田憲明、浅井知浩、清水広介、南野哲男、目加田英輔、奥直人
- Organizer
  第15回遺伝子・デリバリー研究会シンポジウム
- Place of Presentation
  京都
- Year and Date
  2015-05-01
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] PTEN変異に基づく合成致死性を利用したがん治療法の開発2015
- Author(s)
  磯村秀樹、横田将史、浅井知浩、清水広介、出羽毅久、奥直人
- Organizer
  第15回遺伝子・デリバリー研究会シンポジウム
- Place of Presentation
  京都
- Year and Date
  2015-05-01
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] 脂質ナノ粒子を用いた小分子RNAデリバリー技術の開発とがん治療への応用2015
- Author(s)
  浅井知浩、出羽毅久、奥直人
- Organizer
  日本油化学会第54回年会
- Place of Presentation
  名古屋
- Year and Date
  2015-09-10
- Invited
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] Highly efficient RNAi with low concentration of siRNA using novel polycation liposome2015
- Author(s)
  Jiao Li, Sho Ryu, Ayaka Okamoto, Tomohiro Asai, Takehisa Dewa, Naoto Oku
- Organizer
  第61回日本薬学会東海支部総会・大会
- Place of Presentation
  名古屋
- Year and Date
  2015-07-04
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] PLK1 knockdown with lipid nanoparticles encapsulating siRNA for the treatment of cancer2015
- Author(s)
  Ayaka Okamoto, Noriaki Okada, Tomohiro Asai, Tetsuo Minamino, Eisuke Mekada, Naoto Oku
- Organizer
  2015 AAPS Annual Meeting and Exposition
- Place of Presentation
  Orland, USA
- Year and Date
  2015-10-27
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] microRNA全身送達による新規がん治療戦略2015
- Author(s)
  安藤英紀、浅井知浩、奥直人
- Organizer
  第24回DDSカンファランス
- Place of Presentation
  静岡
- Year and Date
  2015-09-04
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] Combination effects of siRNA and Verteporfin in the treatment of breast cancer cells2015
- Author(s)
  Masahiro Hashimoto, Tomohiro Asai, Naoto Oku
- Organizer
  13th US-Japan Symposium on Drug Delivery Systems
- Place of Presentation
  Maui, USA
- Year and Date
  2015-12-18
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] 新規リポソームベクターを用いたsiRNAデリバリー2015
- Author(s)
  宋復燃、岡本彩香、李嬌、小出裕之、浅井知浩、出羽毅久、奥直人
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2015
- Place of Presentation
  名古屋
- Year and Date
  2015-11-01
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] 核酸医薬DDS技術開発におけるデリバリー担体の評価技術2015
- Author(s)
  奥直人、浅井知浩
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎
- Year and Date
  2015-05-22
- Invited
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] RNA干渉治療に向けた新規脂質ナノ粒子の開発2015
- Author(s)
  浅井知浩、奥直人
- Organizer
  第4回創剤カンファレンス静岡
- Place of Presentation
  静岡
- Year and Date
  2015-12-11
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] 腫瘍選択的siRNA送達を目指した機能性ナノキャリアの有用性評価2014
- Author(s)
  岡本彩香、加藤寛己、浅井知浩、清水広介、南野哲男、目加田英輔、奥直人
- Organizer
  日本薬剤学会第29年会
- Place of Presentation
  大宮
- Year and Date
  2014-05-20
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] リポソームを用いた核酸デリバリーシステムに関する研究2014
- Author(s)
  浅井知浩
- Organizer
  日本薬剤学会第29年会
- Place of Presentation
  大宮
- Year and Date
  2014-05-21
- Invited
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] Advanced cancer therapy by systemic administration of miR-499.2014
- Author(s)
  Sho Ryu, Hidenori Ando, Tomohiro Asai, Takehisa Dewa, Tetsuo Minamino, Naoto Oku
- Organizer
  Liposome Research Days 2014
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2014-08-06
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] PARP1ノックダウンによる合成致死誘導に基づくがん治療法2014
- Author(s)
  横田将史、磯村秀樹、浅井知浩、清水広介、出羽毅久、奥　直人
- Organizer
  日本薬剤学会第29年会
- Place of Presentation
  大宮
- Year and Date
  2014-05-20
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] Antibody-modified lipid nanoparticles for tumor-targeted siRNA delivery.2014
- Author(s)
  Ayaka Okamoto, Tomohiro Asai, Hiroki Kato, Kosuke Shimizu, Tetsuo Minamino, Eisuke Mekada, Naoto Oku
- Organizer
  Liposome Research Days 2014
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2014-08-04
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] The design of a liposomal delivery system for the treatment of ischemic stroke.2014
- Author(s)
  Tomohiro Asai, Tatsuya Fukuta, Takayuki Ishii, Akihiko Sato, Takashi Kikuchi, Kosuke Shimizu, Hideo Tsukada, Naoto Oku
- Organizer
  Liposome Research Days 2014
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2014-08-06
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] Cancer therapy with systemic administration of liposomal microRNA-499.2014
- Author(s)
  Sho Ryu, Hidenori Ando, Tomohiro Asai, Takehisa Dewa, Tetsuo Minamino, Naoto Oku
- Organizer
  The 19th Shizuoka Forum on Health and Longevity
- Place of Presentation
  Numazu, Japan
- Year and Date
  2014-11-07
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] Evaluation of antibody-modified lipid nanoparticles for tumor-targeted delivery of siRNA.2014
- Author(s)
  Ayaka Okamoto, Noriaki Okada, Tomohiro Asai, Hiroki Kato, Tetsuo Minamino, Eisuke Mekada, Naoto Oku
- Organizer
  The 2nd International Conference on Pharma and Food
- Place of Presentation
  Shizuoka, Japan
- Year and Date
  2014-11-05
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] 核酸医薬品の開発を目的としたsiPARP1デリバリーと合成致死誘導の検討2014
- Author(s)
  横田将史、磯村秀樹、浅井知浩、清水広介、出羽毅久、奥直人
- Organizer
  第36回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2014-11-21
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] Induction of synthetic lethality by PARP1 knockdown for cancer treatment.2014
- Author(s)
  Masafumi Yokota, Hideki Isomura, Tomohiro Asai, Kosuke Shimizu, Takehisa Dewa, Naoto Oku
- Organizer
  Liposome Research Days 2014
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2014-08-06
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] PARP1ノックダウンによるPTEN欠損ヒト乳がん細胞における合成致死性の誘導2014
- Author(s)
  磯村秀樹、横田将史、清水広介、浅井知浩、出羽毅久、奥　直人
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] Tumor-targeted delivery of siRNA using antibody-modified lipid nanoparticles.2014
- Author(s)
  Ayaka Okamaoto, Tomohiro Asai, Hiroki Kato, Kosuke Shimizu, Tetsuo Minamino, Eisuke Mekada, Naoto Oku
- Organizer
  The 19th Shizuoka Forum on Health and Longevity
- Place of Presentation
  Numazu, Japan
- Year and Date
  2014-11-07
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] Advanced cancer therapy by systemic administration of miR-499.2014
- Author(s)
  39.Sho Ryu, Hidenori Ando, Tomohiro Asai, Takehisa Dewa, Tetsuo Minamino, Naoto Oku
- Organizer
  Liposome Research Days 2014
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2014-08-06
- Data Source
  KAKENHI-PROJECT-26670018
[Presentation] RNA干渉効率の向上を目指した抗体修飾脂質ナノ粒子の開発2014
- Author(s)
  岡田憲明、岡本彩香、清水広介、浅井知浩、南野哲男、目加田英輔、奥直人
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2014
- Place of Presentation
  静岡
- Year and Date
  2014-11-09
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] miR-499全身送達による腫瘍増殖抑制効果2013
- Author(s)
  安藤英紀、浅井知浩、出羽毅久、南野哲男、奥直人
- Organizer
  第23回アンチセンスシンポジウム
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] Enhanced circulation of secondly injected PEGylated liposomes after injection of doxorubicin-encapsulatd PEGylated liposomes2013
- Author(s)
  Jantana Yahuafai, Yuri Kiyokawa, Yoshito Takeuchi, Daiki Saito, Kosuke Shimizu, Tomohiro Asai, Pongpun Siripong, Kenji Hyodo, Hiroshi Ishihara, Hiroshi Kikuchi, Naoto Oku
- Organizer
  The 5 th Conference
- Place of Presentation
  名古屋
- Year and Date
  2013-08-05
- Data Source
  KAKENHI-PROJECT-24659021
[Presentation] 抗体修飾脂質ナノ粒子を用いた腫瘍選択的siRNAデリバリー2013
- Author(s)
  岡本彩香、加藤寛己、都竹拓磨、清水広介、浅井知浩、南野哲男、目加田英輔、奥直人
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] 統合的抗血管新生治療のためのmiR-499細胞内送達技術の構築2013
- Author(s)
  安藤英紀、岡本彩香、横田将史、浅井知浩、出羽毅久、南野哲男、奥直人
- Organizer
  第13回遺伝子･デリバリー研究会シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] Novel cancer therapy by systemic treatment with miR-499.2013
- Author(s)
  Hidenori Ando, Tomohiro Asai, Takehisa Dewa, Tetsuo Minamino, Naoto Oku
- Organizer
  The 18th Shizuoka Forum on Health and Longevity
- Place of Presentation
  Shizuoka, Japan
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] Treatment of PTEN-positive tumors with small interfering RNA targeting the mammalian target of rapamycin.2013
- Author(s)
  Tomohiro Asai, Naoto Oku
- Organizer
  2nd International Conference and Exhibition on Cell & Gene Therapy
- Place of Presentation
  Orlando, USA
- Invited
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] Functional cytoplasmic delivery of microRNA by use of polycation liposomes.2013
- Author(s)
  Hidenori Ando, Ayaka Okamoto, Masafumi Yokota, Tomohiro Asai, Takehisa Dewa, Naoto Oku
- Organizer
  The 5th Asian Arden Conference
- Place of Presentation
  Nagoya, Japan
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] mTORノックダウンによるがん治療を目指した脂質ナノ粒子の有用性検討2013
- Author(s)
  岡本彩香、加藤寛己、都竹拓磨、清水広介、浅井知浩、南野哲男、目加田英輔、奥直人
- Organizer
  第29回日本DDS学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] mi-R499全身送達による新規がん治療戦略2013
- Author(s)
  安藤英紀、浅井知浩、出羽毅久、南野哲男、奥直人
- Organizer
  第29回日本DDS学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] 脂質ナノ粒子を用いた腫瘍新生血管への核酸・薬物デリバリー2013
- Author(s)
  浅井知浩
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-30
- Data Source
  KAKENHI-PROJECT-22790045
[Presentation] miR-499送達による統合的抗血管新生療法2013
- Author(s)
  安藤英紀、浅井知浩、出羽毅久、南野哲男、奥直人
- Organizer
  日本がん分子標的治療学会　第17回学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] Targeted delivery of siRNA to tumors using antibody- modified lipid nanoparticle.2013
- Author(s)
  Ayaka Okamoto, Hidenori Ando, Hiroki Kato, Takuma Tsuzuku, Kosuke Shimizu, Tomohiro Asai, Tetsuo Minamino, Eisuke Mekada, Naoto Oku
- Organizer
  40th Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Honolulu, USA
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] miR-499全身送達による腫瘍新生血管の正常化とがん治療2013
- Author(s)
  安藤英紀、浅井知浩、出羽毅久、南野哲男、奥直人
- Organizer
  第22回DDSカンファランス
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] Tumor-targeted delivery of miR-499 via systemic administration for advanced cancer therapy by vascular normalization.2013
- Author(s)
  Hidenori Ando, Tomohiro Asai, Takehisa Dewa, Tetsuo Minamino, Naoto Oku
- Organizer
  The 40th International Symposium on Nucleic Acids Chemistry 2013
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] ファージライブラリーを用いた長期血中滞留性ペプチドの探索2013
- Author(s)
  清河友理、中田貴志、古屋恵一、清水広介、浅井知浩、奥直人
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-24659021
[Presentation] Increased Half-life of secondly injected PEGylated liposomes in mice pretreated with doxorubicin-encapsulated PEGylated liposome2013
- Author(s)
  Jantana Yahuafai, Tomohiro Asai, Genki Nakamura, Yuri Kiyokawa, Yoshihito Takeuchi, Kosuke Shimizu, Pongpun Siripong, Kenji Hyodo, Hiroshi Ishihara, Hiroshi Kikuchi, Naoto Oku
- Organizer
  International Liposome Society 2013 Meeting Liposome Advances : Progress in Drug and Vaccine Delivery
- Place of Presentation
  London, UK
- Year and Date
  2013-12-14
- Data Source
  KAKENHI-PROJECT-24659021
[Presentation] Cytoplasmic delivery of microRNA by using polycation liposomes.2013
- Author(s)
  Hidenori Ando, Ayaka Okamoto, Masafumi Yokota, Kosuke Shimizu, Tomohiro Asai, Takehisa Dewa, Naoto Oku
- Organizer
  40th Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Honolulu, USA
- Data Source
  KAKENHI-PROJECT-25460041
[Presentation] Identification of a novel peptide targeting to human tumor vasculature for drug delivery2012
- Author(s)
  Takashi Nakada, Koji Hirashima, Yuri Kiyokawa, Kentaro Hatanaka, Kosuke Shimizu, Tomohiro Asai, Nanoto Oku
- Organizer
  Liposome Research Days
- Place of Presentation
  Hangzou, China
- Year and Date
  2012-10-09
- Data Source
  KAKENHI-PROJECT-24659021
[Presentation] 脂質ナノ粒子を用いたsmall RNAデリバリー2012
- Author(s)
  浅井知浩、奥直人
- Organizer
  創剤カンファレンス静岡
- Place of Presentation
  静岡
- Year and Date
  2012-12-14
- Data Source
  KAKENHI-PROJECT-22790045
[Presentation] リポソームDDS技術を応用した脳虚血/再灌流障害治療法の開発2012
- Author(s)
  石井貴之、浅井知浩、尾山大、福田達也、安田和、上戸由里佳、清水広介、南野哲男、奥直人
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-22659010
[Presentation] リポソームDDSを応用した脳虚血時における新規脳保護戦略の構築2012
- Author(s)
  福田達也、石井貴之、尾山大、安田和、上戸由里佳、浅井知浩、清水広介、南野哲男、奥直人
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-22659010
[Presentation] Targeted delivery of small interfering RNA with RGD-decorated polycation liposomes for cancer therapy.2012
- Author(s)
  Tomohiro Asai, Naoto Oku
- Organizer
  Oligonucleotide Delivery: Biology, Engineering and Development
- Place of Presentation
  Hernstein, Austria
- Year and Date
  2012-10-09
- Data Source
  KAKENHI-PROJECT-22790045
[Presentation] 脳虚血再灌流モデルラットにおけるFK506封入PEG修飾リポソームの薬理効果及び脳内挙動の解析2012
- Author(s)
  上戸由里佳、石井貴之、尾山大、安田和、福田達也、浅井知浩、清水広介、南野哲男、奥直人
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-22659010
[Presentation] siRNAイメージング技術の開発とデリバリーシステム研究への応用2012
- Author(s)
  浅井知浩
- Organizer
  第58回日本薬学会東海支部総会・大会
- Place of Presentation
  静岡
- Year and Date
  2012-07-07
- Data Source
  KAKENHI-PROJECT-22790045
[Presentation] Identification of a novel peptide targeting to human tumor vasculature for drug delivery2012
- Author(s)
  T Nakada, K Hirashima, Y Kiyokawa, K Hatanaka, K Shimizu, T Asai, N Oku
- Organizer
  Liposome Research Days 2012
- Place of Presentation
  Hangzhou, China
- Data Source
  KAKENHI-PROJECT-24659021
[Presentation] Treatment of Cerebral Ischemia-Reperfusion Injury with Liposomal Asialo-Erythropoietin2011
- Author(s)
  Dai Oyama, Takayuki Ishii, Tomohiro Asai, Tatsuya Fukuta, Nodoka Yasuda, Kosuke Shimizu, Tetsuo Minamino, Naoto Oku
- Organizer
  Liposomes Jerusalem 2011
- Place of Presentation
  Jerusalem Israel
- Year and Date
  2011-05-15
- Data Source
  KAKENHI-PROJECT-22659010
[Presentation] リポソームDDSによる腫瘍新生血管傷害療法2011
- Author(s)
  浅井知浩
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-22790045
[Presentation] 脳虚血再灌流障害治療に向けたFK506封入PEG修飾リポソームの応用2011
- Author(s)
  安田和、石井貴之、尾山大、上戸由里佳、福田達也、浅井知浩、清水広介、南野哲男、奥直人
- Organizer
  第33回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  岡山
- Year and Date
  2011-11-24
- Data Source
  KAKENHI-PROJECT-22659010
[Presentation] Application of liposomal DDS for the treatment of ischemia/reperfusion injury2011
- Author(s)
  Naoto Oku, Takayuki Ishii, Dai Oyama, Tatsuya Fukuta, Nodoka Yasuda, Kosuke Shimizu, Tomohiro Asai, Tetsuo Minamino
- Organizer
  International Liposome Society 2011 Meeting
- Place of Presentation
  London, UK
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-22659010
[Presentation] リポソームDDSによるAsialo-erythropoietinの脳虚血再灌流障害抑制効果の増強2011
- Author(s)
  石井貴之、浅井知浩、福田達也、尾山大、安田和、清水広介、南野哲男、奥直人
- Organizer
  第27回日本DDS学会
- Place of Presentation
  東京
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-22659010
[Presentation] Liposomal Drug Delivery System as a Potential Strategy for the Treatment of Cerebral Ischemia-Reperfusion Injury2011
- Author(s)
  Takayuki Ishii, Tomohiro Asai, Dai Oyama, Tatsuya Fukuta, Nodoka Yasuda, Kosuke Shimizu, Tetsuo Minamino, Naoto Oku
- Organizer
  Liposomes Jerusalem 2011
- Place of Presentation
  Jerusalem Israel
- Year and Date
  2011-05-15
- Data Source
  KAKENHI-PROJECT-22659010
[Presentation] RNA創薬に向けたsiRNA体内動態のPETイメージング2010
- Author(s)
  浅井知浩, ら
- Organizer
  第56回日本薬学会東海支部総会・大会
- Place of Presentation
  岐阜
- Year and Date
  2010-07-03
- Data Source
  KAKENHI-PROJECT-22790045
[Presentation] Treatment of cerebral ischemia-reperfusion injury by liposomal drug delivery system2010
- Author(s)
  Takayuki Ishii, Dai Oyama, Tomohiro Asai, Kosuke Shimizu, Tetsuo Minamino, Naoto Oku
- Organizer
  LRD/LLMB 2010 Conference
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2010-08-04
- Data Source
  KAKENHI-PROJECT-22659010
[Presentation] リポソームを用いた全身投与型siRNAデリバリーシステムの開発2010
- Author(s)
  浅井知浩
- Organizer
  第28回製剤設計研究会
- Place of Presentation
  東京
- Year and Date
  2010-10-23
- Data Source
  KAKENHI-PROJECT-22790045
[Presentation] Pharmacokinetic PET studies of liposomal siRNA2010
- Author(s)
  Tomohiro Asai, et al.
- Organizer
  LRD/LLMB 2010 Conference
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2010-08-04
- Data Source
  KAKENHI-PROJECT-22790045
[Presentation] Development of PET technology to determine pharmacokinetics of siRNA medicine.2009
- Author(s)
  Tomohiro Asai
- Organizer
  APSTJ Global Education Seminar East 2009-03
- Place of Presentation
  東京
- Year and Date
  2009-10-05
- Data Source
  KAKENHI-PROJECT-19790131
[Presentation] PET technology to determine pharmacokinetics of liposomal siRNA.2009
- Author(s)
  Asai, T., et al.
- Organizer
  4th International Liposome Society Conference
- Place of Presentation
  London, UK
- Year and Date
  2009-12-14
- Data Source
  KAKENHI-PROJECT-19790131
[Presentation] siRNA体内動態のPET解析と新規ベクターの開発2009
- Author(s)
  浅井知浩, ら
- Organizer
  第25回日本DDS学会
- Place of Presentation
  東京
- Year and Date
  2009-07-03
- Data Source
  KAKENHI-PROJECT-19790131
[Presentation] PET technology to determine pharmacokinetics of liposomal siRNA2009
- Author(s)
  Tomohiro Asai, et al
- Organizer
  4th International Liposome Society Conference
- Place of Presentation
  London, UK
- Year and Date
  2009-12-14
- Data Source
  KAKENHI-PROJECT-19790131
[Presentation] Angiogenic vessel-targeted liposomes for in vivo delivery of siRNA2008
- Author(s)
  Asai, T., et.al.
- Organizer
  Japan Society of Gene Therapy. The 14th Annual Meeting 2008
- Place of Presentation
  札幌
- Year and Date
  2008-06-14
- Data Source
  KAKENHI-PROJECT-19790131
[Presentation] Angiogenic vessel-targeted liposomal DDS for cancer treatment2008
- Author(s)
  Asai, T., et.al.
- Organizer
  11th Liposome Research Days Conference
- Place of Presentation
  横浜
- Year and Date
  2008-08-20
- Data Source
  KAKENHI-PROJECT-19790131
[Presentation] Angiogenic vessel-targeted liposomal DDS for cancer treatment.2008
- Author(s)
  Asai, T., et al.
- Organizer
  11th Liposome Research Days Conference
- Place of Presentation
  横浜
- Year and Date
  2008-07-20
- Data Source
  KAKENHI-PROJECT-19790131
[Presentation] Angiogenic vessel-targeted liposomes for in vivo delivery of siRNA.2008
- Author(s)
  Asai, T., et al.
- Organizer
  Japan Society of Gene Therapy. The 14th Annual Meeting
- Place of Presentation
  札幌
- Year and Date
  2008-06-14
- Data Source
  KAKENHI-PROJECT-19790131
[Presentation] Development of Antineovascular RNAi Cancer Therapy Targeting to Argonaute22007
- Author(s)
  Tomohiro Asai, et. al.
- Organizer
  American Society of Gene Therapy 10th Annual Meeting
- Place of Presentation
  Seattle,WA,USA
- Year and Date
  2007-05-31
- Data Source
  KAKENHI-PROJECT-19790131
[Presentation] Increased Half-life of secondly injected PEGylated liposomes in mice pretreated with doxorubicin-encapsulated PEGylated liposomes
- Author(s)
  Jantana Yafuafai, Tomohiro Asai, Genki Nakamura, Yuri Kiyokawa, Yoshihito Takeuchi, Kosuke Shimizu, Pongpun Siripong, Kenji Hyodo, Hiroshi Ishihara, Hiroshi Kikuchi, Naoto Oku
- Organizer
  International Liposome Society 2013 Meeting
- Place of Presentation
  London UK
- Data Source
  KAKENHI-PROJECT-24659021
[Presentation] Enhanced circulation of secondly injected PEGylated liposomes after injection of doxorubicin-encapsulatd PEGylated liposomes
- Author(s)
  Jantana Yahuafai, Yuri Kiyokawa, Yoshito Takeuchi, Daiki Saito, Kosuke Shimizu, Tomohiro Asai, Pongpun Siripong, Kenji Hyodo, Hiroshi Ishihara, Hiroshi Kikuchi, Naoto Oku
- Organizer
  The 5th Asian Arden Conference
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24659021
[Presentation] siRNAイメージング技術の開発とデリバリーシステム研究への応用
- Author(s)
  浅井知浩
- Organizer
  第58回日本薬学会東海支部総会･大会
- Place of Presentation
  静岡
- Invited
- Data Source
  KAKENHI-PROJECT-22790045
[Presentation] Targeted delivery of small interfering RNA with RGD-decorated polycation liposomes for cancer therapy
- Author(s)
  Tomohiro Asai et al
- Organizer
  Oligonucleotide Delivery
- Place of Presentation
  Hernstein, Austria
- Invited
- Data Source
  KAKENHI-PROJECT-22790045
[Presentation] 脂質ナノ粒子を用いた腫瘍新生血管への核酸・薬物デリバリー
- Author(s)
  浅井知浩ら
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-22790045
[Presentation] 脂質ナノ粒子を用いたsmall RNAデリバリー
- Author(s)
  浅井知浩ら
- Organizer
  創剤カンファレンス静岡
- Place of Presentation
  静岡
- Invited
- Data Source
  KAKENHI-PROJECT-22790045

1. OKU Naoto (10167322)

# of Collaborated Projects: 11 results

# of Collaborated Products: 93 results
2. SHIMIZU Kosuke (30423841)

# of Collaborated Projects: 9 results

# of Collaborated Products: 46 results
3. Koide Hiroyuki (60729177)

# of Collaborated Projects: 4 results

# of Collaborated Products: 42 results
4. MINAMINO TETSUO (30379234)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. Kobayashi Taku (10424144)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NAKANO Masaru (50265807)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Kaku Yoshihiro (70392321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 池本守 (90311331)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 松崎高志 (90456939)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 村上和司 (60575207)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 野間貴久 (20363202)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 富海英 (70754646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 羽尾裕之 (40393243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 馬渡健一 (70190577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 星野友 (40554689)

# of Collaborated Projects: 1 results

# of Collaborated Products: 20 results
16. 五十里彰 (50315850)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 横山英志 (70433208)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 米澤正 (50469988)

# of Collaborated Projects: 1 results

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19. 池田潔 (40168125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. TAKASHIMA Seiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. ASANO Yoshihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
22. ASAKURA Masanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
23. OGATA Makoto

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. KATO Hisakazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. HARADA Norihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. ASAKAWA Tomohiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. MIN Kyung-Duk

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. SANADA Shoji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 石川吉伸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 北風政史

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# of Collaborated Products: 2 results
31. 浅沼博司

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# of Collaborated Products: 2 results
32. 福田達也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 目加田英輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
34. 宋復燃

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 川島博人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 本田美樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 荒木慶彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 菅敏幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
39. 間賀田泰寛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 肥後修一朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 川口章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 横山昌幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 白石貢一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 赤井周司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
45. 濱島義隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ASAI Tomohiro 浅井 知浩

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抗原提示細胞を標的としたmRNA/LNP製剤の開発と個別化がん免疫療法への応用Principal Investigator

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好中球を担体とした独創的DDSの開発と炎症性疾患治療への応用Principal Investigator

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Design and construction of neutrophil-mediated drug delivery systemPrincipal Investigator

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Development of functional lipid nanoparticles for RNA interference-based therapyPrincipal Investigator

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Delivery of siRNA for synthetic lethality-based cancer therapyPrincipal Investigator

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ASAI Tomohiro 浅井知浩