Koide Hiroyuki 小出裕之

… Alternative Names

KOIDE Hiroyuki 小出裕之

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Researcher Number	60729177
Other IDs
Affiliation (Current)	2025: 静岡県立大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2025: 静岡県立大学, 薬学部, 准教授 2018 – 2021: 静岡県立大学, 薬学部, 講師 2016 – 2017: 静岡県立大学, 薬学部, 助教 2014: 静岡県立大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Transformative Research Areas, Section (II) / Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 90120:Biomaterials-related / Medium-sized Section 47:Pharmaceutical sciences and related fields / Basic Section 90110:Biomedical engineering-related / Bio-related chemistry / Polymer chemistry Except Principal Investigator Transformative Research Areas, Section (II) / Physical pharmacy / Medium-sized Section 90:Biomedical engineering and related fields … More / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Basic Section 47060:Clinical pharmacy-related / Basic Section 35010:Polymer chemistry-related / General pharmacology Less
Keywords	Principal Investigator ナノ粒子 / がん / 抗体 / 分子認識 / 高分子 / 精密高分子 / 経口投与 / 脂質ナノ粒子 / 吸着剤 / 解毒剤 … More / アミノ酸 / 毒素 / ペプチド / 精密高分子医薬 / プラスチック抗体 / 均一オリゴマー / 解毒 / リポソーム / 敗血症 / オリゴマー / 脂質二重膜小胞 / mRNA / 取り込み / 細胞外小胞 / 薬物送達 / エクソソーム / 腎不全 / N-Isopropylacrylamide / 体内動態 / 潰瘍性大腸炎 / 多価効果 / 腎疾患 / 糖尿病 / 合成高分子 / ナノ材料 / 腎臓病 / 慢性腎臓病 / ポリマーナノ粒子 / 尿毒症 / インドール / 低分子 / 糖 / 血管新生 / VEGF … More Except Principal Investigator リポソーム / 制御ラジカル重合 / 精密高分子 / プラスチック抗体 / 高分子進化 / 分子進化工学 / ナノ粒子 / 薬物送達 / 進化工学 / データ科学 / PEG / ビメンチン / 抗体 / 循環がん細胞 / drug delivery system / ワクチン / 抗原提示細胞 / mRNA / 脂質ナノ粒子 / ラジカル重合 / アプタマー / 高分子合成 / 創薬 / 均一高分子 / 結合性評価 / ポリクローナル抗体 / 膜タンパク抗体 / 抗血清 / エキソソーム / 膜タンパク / 抗体誘導 / 脾臓免疫 / エクソソーム / プラスチックアプタマー / ブロック重合 / 量体分離 / 均一オリゴマー / ブロック共重合 / アフィニティー精製 / 分子認識 / 癌幹細胞 / 癌 / エンドサイトーシス / リポプレックス / 前立腺がん / 異種移植 / マウス / ゼブラフィッシュ / ペプチド修飾 / ＭＭＰ / 脳出血抑制 / ＰＤＧＦ / アクティブターゲティング / 血栓溶解剤 / 脳梗塞 / 治療可能時間 / 脳血管障害 / DDS / 脳血管疾患 / 虚血性疾患 / 組織プラスミノーゲン活性化因子 / ファスジル / 薬物送達システム / 脳梗塞治療 / 解毒 / 人工抗体 / 中和活性 / 毒素 / ポリマーリガンド / ポリマー粒子 / 膜流動性 / 毒素の中和 / ヒストン / 敗血症 / ノンインプリント人工抗体 Less

Drug development through data-driven evolutionary engineering of precision polymers
- Principal Investigator
  
  星野友
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Kyushu University
がん治療を可能とする精密高分子医薬の開発Principal Investigator
- Principal Investigator
  
  小出裕之
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  University of Shizuoka
高機能細胞外小胞の生物学的機能解析とがん治療法の開発Principal Investigator
- Principal Investigator
  
  小出裕之
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  University of Shizuoka
警告を受けた循環がん細胞を強制退場させるレフェリーナノ粒子の創製
- Principal Investigator
  
  清水広介
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Hamamatsu University School of Medicine
Exploration of highly functional exosomes using a continuous media recovery system and its application to drug deliveryPrincipal Investigator
- Principal Investigator
  
  Koide Hiroyuki
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  University of Shizuoka
Development of next-generation pharmaceuticals through evolutionary engineering of p recision polymers
- Principal Investigator
  
  星野友
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Kyushu University
Polymer evolution for medical applicationPrincipal Investigator
- Principal Investigator
  
  小出裕之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  University of Shizuoka
抗原提示細胞を標的としたmRNA/LNP製剤の開発と個別化がん免疫療法への応用
- Principal Investigator
  
  浅井知浩
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  University of Shizuoka
Development of biomimetic nano-antibody that neutralizes target molecules in blood for cancer therapyPrincipal Investigator
- Principal Investigator
  
  小出裕之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  University of Shizuoka
Establishment of a spleen immunization technology platform using exosomes to induce antibodies that can recognize the membrane proteins of host cells.
- Principal Investigator
  
  ANDO Hidenori
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  The University of Tokushima
Development of plastic antibodies based on homogenous oligomer libraries
- Principal Investigator
  
  Hoshino Yu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 35010:Polymer chemistry-related
- Research Institution
  Kyushu University
Development of plastic antibodies that inhibit intestinal absorption of target moleculesPrincipal Investigator
- Principal Investigator
  
  Koide Hiroyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  University of Shizuoka
Design of Synthetic Polymer Nanoparticles Specifically Capturing Indole for improvement of uremia symptomPrincipal Investigator
- Principal Investigator
  
  Koide Hiroyuki
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bio-related chemistry
- Research Institution
  University of Shizuoka
Endocytosis-independent membrane fusion peptides for cancer stem cell drug delivery
- Principal Investigator
  
  Shimada Yasuhito
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Mie University
Development of liposomal plastic antibody for novelDDS and applicaion for sepsis treatment
- Principal Investigator
  
  Oku Naoto
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka
Development of FA-Snap, a smart DDS drug, for proposing an innovative therapeutic modality of ischemic stroke.
- Principal Investigator
  
  OKU Naoto
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Teikyo University
  University of Shizuoka
Development of a novel plastic nanomedicine for anti-angiogenic cancer therapy.Principal Investigator
- Principal Investigator
  
  KOIDE Hiroyuki
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Polymer chemistry
- Research Institution
  University of Shizuoka

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014

All Journal Article Presentation Book Patent

[Book] 医学のあゆみ2022
- Author(s)
  小出裕之、星野友
- Total Pages
  4
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-ORGANIZER-22H05047
[Book] 生体内で標的高分子を吸着してその機能を中和するプラスチック抗体2018
- Author(s)
  小出裕之、奥直人、星野友、三浦佳子
- Publisher
  月刊プラスチック
- Data Source
  KAKENHI-PROJECT-17K14519
[Book] 標的分子を吸着してその機能を無毒化するプラスチック抗体開発2018
- Author(s)
  小出裕之
- Publisher
  化学工業
- Data Source
  KAKENHI-PROJECT-17K14519
[Journal Article] Cooling-induced, localized release of cytotoxic peptides from engineered polymer nanoparticles in living mice for cancer therapy2023
- Author(s)
  Koide Hiroyuki、Saito Kazuhiro、Yoshimatsu Keiichi、Chou Beverly、Hoshino Yu、Yonezawa Sei、Oku Naoto、Asai Tomohiro、Shea Kenneth J.
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 355 Pages: 745-759
- DOI
  10.1016/j.jconrel.2023.02.020
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19384, KAKENHI-ORGANIZER-22H05047, KAKENHI-PLANNED-22H05048, KAKENHI-PROJECT-22K19940, KAKENHI-PLANNED-22H05051, KAKENHI-PROJECT-23K25211
[Journal Article] Design of an Anti-HMGB1 Synthetic Antibody for <i>In Vivo</i> Ischemic/Reperfusion Injury Therapy2023
- Author(s)
  Koide Hiroyuki、Kiyokawa Chiaki、Okishima Anna、Saito Kaito、Yoshimatsu Keiichi、Fukuta Tatsuya、Hoshino Yu、Asai Tomohiro、Nishimura Yuri、Miura Yoshiko、Oku Naoto、Shea Kenneth J.
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 145 Issue: 42 Pages: 23143-23151
- DOI
  10.1021/jacs.3c06799
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19940, KAKENHI-ORGANIZER-22H05047, KAKENHI-PLANNED-22H05048, KAKENHI-PLANNED-22H05051
[Journal Article] Engineering Temperature-Responsive Polymer Nanoparticles that Load and Release Paclitaxel, a Low-Molecular-Weight Anticancer Drug2023
- Author(s)
  Koide Hiroyuki、Yamaguchi Kazuma、Sato Keijiro、Aoshima Maki、Kanata Shoko、Yonezawa Sei、Asai Tomohiro
- Journal Title
  
  ACS Omega
  
  Volume: 9 Issue: 1 Pages: 1011-1019
- DOI
  10.1021/acsomega.3c07226
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22H05051, KAKENHI-PROJECT-23K25211
[Journal Article] Treatment of PTEN-Null Breast Cancer by a Synthetic Lethal Approach Involving PARP1 Gene Silencing2023
- Author(s)
  Asai Tomohiro、Yokota Masafumi、Isomura Hideki、Koide Hiroyuki、Sakurai Naoyuki、Okamoto Ayaka、Ando Hidenori、Dewa Takehisa、Oku Naoto
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: - Issue: 7 Pages: 1908-1914
- DOI
  10.1016/j.xphs.2023.02.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19384, KAKENHI-PROJECT-23K25211, KAKENHI-PROJECT-22K19940, KAKENHI-PROJECT-23K24016
[Journal Article] Increasing the siRNA knockdown efficiency of lipid nanoparticles by morphological transformation with the use of dihydrosphingomyelin as a helper lipid2023
- Author(s)
  Hashimoto Masahiro、Yonezawa Sei、Furan Song、Nitta Chiori、Maeda Noriyuki、Tomita Koji、Yokouchi Ayano、Koide Hiroyuki、Asai Tomohiro
- Journal Title
  
  Biomaterials Science
  
  Volume: - Issue: 9 Pages: 3269-3277
- DOI
  10.1039/d3bm00068k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19384, KAKENHI-PROJECT-23K25211, KAKENHI-PROJECT-22K19940, KAKENHI-PROJECT-23K24016
[Journal Article] Easy preparation of a liposome-mediated protein delivery system by freeze-thawing a liposome-protein complex.2022
- Author(s)
  Koide H, Ochiai H, Suzuki H, Hirata S, Watanabe M, Yonezawa S, Dewa T, Oku N, Asai T.
- Journal Title
  
  J Mater Chem B
  
  Volume: 10 Issue: 35 Pages: 6768-6776
- DOI
  10.1039/d2tb00271j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19940, KAKENHI-PROJECT-21KK0088, KAKENHI-PUBLICLY-22H05416, KAKENHI-PROJECT-23K24016
[Journal Article] 敗血症治療のセレンディピティ2022
- Author(s)
  1)小出裕之、星野友
- Journal Title
  
  医学のあゆみ
  
  Volume: 282 Pages: 809-812
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22H05051
[Journal Article] Design of Functional Nanoparticles for Intractable Disease Therapy2021
- Author(s)
  Koide Hiroyuki
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 44 Issue: 1 Pages: 1-6
- DOI
  10.1248/bpb.b20-00699
- NAID
  130007965325
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2021-01-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H04450
[Journal Article] Enhancement of target toxin neutralization effect in?vivo by PEGylation of multifunctionalized lipid nanoparticles2021
- Author(s)
  Koide Hiroyuki、Suzuki Hikaru、Ochiai Hiroki、Egami Hiromichi、Hamashima Yoshitaka、Oku Naoto、Asai Tomohiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 555 Pages: 32-39
- DOI
  10.1016/j.bbrc.2021.03.073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21905, KAKENHI-PROJECT-19H04450
[Journal Article] Synthetic hydrogel nanoparticles for sepsis therapy2021
- Author(s)
  Koide Hiroyuki、Okishima Anna、Hoshino Yu、Kamon Yuri、Yoshimatsu Keiichi、Saito Kazuhiro、Yamauchi Ikumi、Ariizumi Saki、Zhou Yuqi、Xiao Ting-Hui、Goda Keisuke、Oku Naoto、Asai Tomohiro、Shea Kenneth J.
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 5552-5552
- DOI
  10.1038/s41467-021-25847-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21905, KAKENHI-PROJECT-19H04450, KAKENHI-PROJECT-21J10990
[Journal Article] Influence of Purification Process on the Function of Synthetic Polymer Nanoparticles2021
- Author(s)
  Yasuno Go、Koide Hiroyuki、Oku Naoto、Asai Tomohiro
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 69 Issue: 8 Pages: 773-780
- DOI
  10.1248/cpb.c21-00273
- NAID
  130008070212
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2021-08-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21905, KAKENHI-PROJECT-19H04450
[Journal Article] siRNA Vehicles for High Endosomal Escapability2021
- Author(s)
  Koide Hiroyuki、Yonezawa Sei、Asai Tomohiro
- Journal Title
  
  Methods Mol Biol
  
  Volume: 2282 Pages: 171-179
- DOI
  10.1007/978-1-0716-1298-9_11
- ISBN
  9781071612972, 9781071612989
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21905, KAKENHI-PROJECT-19H04450
[Journal Article] Design of Synthetic Polymer Nanoparticles That Capture and Neutralize Target Molecules2021
- Author(s)
  Koide Hiroyuki
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 141 Issue: 9 Pages: 1079-1086
- DOI
  10.1248/yakushi.21-00125
- NAID
  130008081768
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2021-09-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H04450
[Journal Article] Design of abiotic polymer ligand-decorated lipid nanoparticles for effective neutralization of target toxins in the blood2021
- Author(s)
  Koide Hiroyuki、Yamauchi Ikumi、Hoshino Yu、Yasuno Go、Okamoto Takumi、Akashi Sotaro、Saito Kazuhiro、Oku Naoto、Asai Tomohiro
- Journal Title
  
  Biomaterials Science
  
  Volume: 9 Issue: 16 Pages: 5588-5598
- DOI
  10.1039/d1bm00515d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21905, KAKENHI-PROJECT-19H04450
[Journal Article] Design of synthetic polymer nanoparticles that inhibit glucose absorption from the intestine2021
- Author(s)
  Koide Hiroyuki、Hayashi Naoki、Yasuno Go、Okishima Anna、Hoshino Yu、Egami Hiromichi、Hamashima Yoshitaka、Oku Naoto、Asai Tomohiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 561 Pages: 1-6
- DOI
  10.1016/j.bbrc.2021.05.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21905, KAKENHI-PROJECT-19H04450
[Journal Article] Engineering of lipid nanoparticles by the multifunctionalization of the surface with amino acid derivatives for the neutralization of a target toxic peptide.2020
- Author(s)
  Koide H, Hirano S, Ide T, Saito K, Suzuki H, Yasuno G, Hamashima Y, Yonezawa S, Oku N, Asai T
- Journal Title
  
  Adv Funct Mater.
  
  Volume: 31 Issue: 3 Pages: 2005641-2005641
- DOI
  10.1002/adfm.202005641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21905, KAKENHI-PROJECT-19H04450
[Journal Article] Rigorous control of vesicle-forming lipid pKa by fluorine-conjugated bioisosteres for gene-silencing with siRNA.2019
- Author(s)
  Okamoto A, Koide H, Morita N, Hirai Y, Kawato Y, Egami H, Hamashima Y, Asai T, Dewa T, Oku N.
- Journal Title
  
  J. Control. Release.
  
  Volume: 295 Pages: 87-92
- DOI
  10.1016/j.jconrel.2018.12.044
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08201, KAKENHI-PROJECT-17K14519, KAKENHI-PROJECT-19H03353
[Journal Article] Engineering the Binding Kinetics of Synthetic Polymer Nanoparticles for siRNA Delivery2019
- Author(s)
  Hiroyuki Koide, Tatsuya Fukuta, Anna Okishima, Saki Ariizumi, Chiaki Kiyokawa, Hiroki Tsuchida, Masahiko Nakamoto, Keiichi Yoshimatsu, Hidenori Ando, Takehisa Dewa, Tomohiro Asai, Naoto Oku, Yu Hoshino, Kenneth J. Shea
- Journal Title
  
  Biomacromolecules
  
  Volume: 20 Issue: 10 Pages: 3648-3657
- DOI
  10.1021/acs.biomac.9b00611
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04450
[Journal Article] Design of Synthetic Polymer Nanoparticles Specifically Capturing Indole, a Small Toxic Molecule.2019
- Author(s)
  Okishima A, Koide H, Hoshino Y, Egami H, Hamashima Y, Oku N, Asai T.
- Journal Title
  
  Biomacromolecules
  
  Volume: 20 Issue: 4 Pages: 1644-1654
- DOI
  10.1021/acs.biomac.8b01820
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14519
[Journal Article] Systemic administration of siRNA with anti-HB-EGF antibody-modified lipid nanoparticles for the treatment of triple-negative breast cancer.2018
- Author(s)
  Okamoto A, Asai T, Hirai Y, Shimizu K, Koide H, Minamino T, Oku N
- Journal Title
  
  Mol Pharm.
  
  Volume: 15 Issue: 4 Pages: 1495-1504
- DOI
  10.1021/acs.molpharmaceut.7b01055
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08201, KAKENHI-PROJECT-17K14519, KAKENHI-PROJECT-15H04821, KAKENHI-PROJECT-15J11660
[Journal Article] Rational designing of an antidote nanoparticle decorated with abiotic polymer ligands for capturing and neutralizing target toxins.2017
- Author(s)
  Koide H, Tsuchida H, Nakamoto M, Okishima A, Ariizumi S, Kiyokawa C, Asai T, Hoshino Y, Oku N.
- Journal Title
  
  J Control Release
  
  Volume: 268 Pages: 335-342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K14519
[Journal Article] Combination therapy with liposomal neuroprotectants and tissue plasminogen activator for treatment of ischemic stroke.2017
- Author(s)
  Fukuta T, Asai T, Yanagida Y, Namba M, Koide H, Shimizu K, Oku N.
- Journal Title
  
  The FASEB Journal
  
  Volume: 印刷中 Issue: 5 Pages: 1879-1890
- DOI
  10.1096/fj.201601209r
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02569, KAKENHI-PROJECT-14J10730, KAKENHI-PROJECT-16K08201, KAKENHI-PROJECT-16H05081
[Journal Article] A polymer nanoparticle with engineered affinity for a vascular endothelial growth factor (VEGF165)2017
- Author(s)
  Hiroyuki Koide,Keiichi Yoshimatsu,Yu Hoshino,Shih-Hui Lee,Ai Okajima,Saki Ariizumi, Yudai Narita,Yusuke Yonamine,Adam C. Weisman,Yuri Nishimura,Naoto Oku,Yoshiko Miura,Kenneth J. Shea
- Journal Title
  
  Nature Chemistry
  
  Volume: 9 Issue: 7 Pages: 715-722
- DOI
  10.1038/nchem.2749
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03818, KAKENHI-PROJECT-16K14007, KAKENHI-PROJECT-17K14519, KAKENHI-PROJECT-16K15111
[Journal Article] Rational designing of an antidote nanoparticle decorated with abiotic polymer ligands for capturing and neutralizing target toxins.2017
- Author(s)
  Koide H, Tsuchida H, Nakamoto M, Okishima A, Ariizumi S, Kiyokawa C, Asai T, Hoshino Y, Oku N
- Journal Title
  
  J. Control. Release.
  
  Volume: 68 Pages: 335-342
- DOI
  10.1016/j.jconrel.2017.10.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08201, KAKENHI-PROJECT-16K15111
[Journal Article] Non-invasive evaluation of neuroprotective drug candidates for cerebral infarction by PET imaging of mitochondrial complex-1 activity2016
- Author(s)
  Tatsuya Fukuta, Tomohiro Asai, Takayuki Ishii, Hiroyuki Koide, Chiaki Kiyokawa, Masahiro Hashimoto, Takashi Kikuchi, Kosuke Shimizu, Norihiro Harada, Hideo Tsukada, Naoto Oku
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 30127-30127
- DOI
  10.1038/srep30127
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H02569, KAKENHI-PROJECT-14J10730, KAKENHI-PROJECT-16K08201, KAKENHI-PROJECT-16H05081
[Journal Article] Neuroprotection against cerebral ischemia/reperfusion injury by intravenous administration of liposomal fasudil2016
- Author(s)
  Fukuta T, Asai T, Sato A, Namba M, Yanagida Y, Kikuchi T, Koide H, Shimizu K, Oku N.
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 506 Issue: 1-2 Pages: 129-137
- DOI
  10.1016/j.ijpharm.2016.04.046
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-14J10730, KAKENHI-PROJECT-25460041, KAKENHI-PROJECT-15H02569, KAKENHI-PROJECT-16H05081
[Journal Article] Susceptibility of PTEN-positive metastatic tumors to small interfering RNA targeting the mammalian target of rapamycin.2015
- Author(s)
  Hiroyuki Koide, Tomohiro Asai, Hiroki Kato, Norihito Yonenaga, Masafumi Yokota, Hidenori Ando, Takehisa Dewa, Mamoru Nango, Noriyuki Maeda, Naoto Oku
- Journal Title
  
  Nanomedicine
  
  Volume: 11 Issue: 1 Pages: 185-194
- DOI
  10.1016/j.nano.2014.09.003
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26888014, KAKENHI-PROJECT-25460041
[Journal Article] Preparation of abiotic polymer nanoparticles for sequestration and neutralization of a target peptide toxin2015
- Author(s)
  Keiichi Yoshimatsu, Hiroyuki Koide, Yu Hoshino, Kenneth J Shea
- Journal Title
  
  Nature Protocols
  
  Volume: 10 Issue: 4 Pages: 595-604
- DOI
  10.1038/nprot.2015.032
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26888014
[Patent] インドール及びその誘導体吸着材2018
- Inventor(s)
  小出裕之、星野友、沖嶋杏奈、奥直人
- Industrial Property Rights Holder
  小出裕之、星野友、沖嶋杏奈、奥直人
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17K14519
[Patent] インドール及びその誘導体吸着剤2018
- Inventor(s)
  小出裕之、沖嶋杏奈、星野　友、奥　直人
- Industrial Property Rights Holder
  小出裕之、沖嶋杏奈、星野　友、奥　直人
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17K14519
[Presentation] Synthetic hydrogel nanoparticles that capture histones in the bloodstream of living mice for sepsis therapy2023
- Author(s)
  Hiroyuki Koide, Yu Hoshino, Naoto Oku, Kenneth J. Shea, Tomohiro Asai
- Organizer
  2023 Nanomedicine and Drug Delivery Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05051
[Presentation] タンパク質の細胞内送達を目的とした多官能性リポソームの開発2023
- Author(s)
  平田真也、小出裕之、渡邉翠、江上寛通、濱島義隆、出羽毅久、奥直人、浅井知浩
- Organizer
  第38回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24016
[Presentation] 消化管で標的分子を吸着するナノ掃除機の開発2023
- Author(s)
  小出裕之
- Organizer
  第６回BVA創薬研究会
- Invited
- Data Source
  KAKENHI-ORGANIZER-22H05047
[Presentation] 精密高分子医用応用2023
- Author(s)
  小出裕之
- Organizer
  第13回CSJ化学フェスタ
- Data Source
  KAKENHI-PLANNED-22H05051
[Presentation] タンパク質の細胞内送達を可能とする多官能性リポソームの開発2023
- Author(s)
  渡邉翠、小出裕之、平田真也、落合広樹、出羽毅久、奥直人、浅井知浩
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会 2023
- Data Source
  KAKENHI-PROJECT-23K24016
[Presentation] ポリマーナノ粒子の細胞への取り込み量と排泄量の関係2023
- Author(s)
  佐藤慶次朗、小出裕之、山口和馬、浅井知浩
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-ORGANIZER-22H05047
[Presentation] 標的毒素に結合してその毒性を中和する生分解性解毒剤の開発2023
- Author(s)
  山田遥香、小出裕之、齋藤海斗、丸橋春日、浅井知浩
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会
- Data Source
  KAKENHI-PROJECT-23K25211
[Presentation] Development of multi-functionalized liposomes with high affinity for target proteins for intracellular protein delivery2023
- Author(s)
  Shinya Hirata, Hiroyuki Koide, Midori Watanabe, Hiromichi Egami, Yoshitaka Hamashima, Takehisa Dewa, Naoto Oku, Tomohiro Asai
- Organizer
  2023 Nanomedicine and Drug Delivery Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24016
[Presentation] 標的毒素に結合してその毒性を中和可能な生分解性解毒剤開発2023
- Author(s)
  齋藤海斗、小出裕之、丸橋春日、山田遥香、浅井知浩
- Organizer
  第44回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-23K25211
[Presentation] 血液中で標的分子を吸着する均一オリゴマー修飾リポソームの開発2023
- Author(s)
  岡本卓巳、小出裕之、星野友、奥直人、浅井知浩
- Organizer
  第38回日本DDS学会学術集会
- Data Source
  KAKENHI-PLANNED-22H05051
[Presentation] 血液中で標的分子を吸着・中和するナノ粒子開発と疾患治療への応用2023
- Author(s)
  小出裕之
- Organizer
  インタラクティブフォーラム（ABC-InFO）
- Invited
- Data Source
  KAKENHI-ORGANIZER-22H05047
[Presentation] 経口投与されたポリマーナノ粒子の体内動態に影響する因子の模索2023
- Author(s)
  安野豪、小出裕之、米澤正、浅井知浩
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-ORGANIZER-22H05047
[Presentation] 血液中で標的分子を吸着する均一オリゴマー修飾リポソームの開発2023
- Author(s)
  岡本卓巳、小出裕之、星野友、奥直人、浅井知浩
- Organizer
  第38回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24016
[Presentation] 経口投与されたポリマーナノ粒子の体内動態に影響を与える因子の模索2022
- Author(s)
  安野豪、小出裕之、米澤正、浅井知浩
- Organizer
  第71回高分子討論会
- Data Source
  KAKENHI-ORGANIZER-22H05047
[Presentation] 凍結融解による簡便なタンパク質内封リポソームの調製とタンパク質の細胞内送達への応用2022
- Author(s)
  平田真也、小出裕之、落合広樹、鈴木ひかる、出羽毅久、奥直人、浅井知浩
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-22K19384
[Presentation] 敗血症治療を可能とする合成高分子ナノ粒子開発2022
- Author(s)
  小出裕之
- Organizer
  第17回ナノ・バイオメディカル学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K25211
[Presentation] 生体内で標的分子を吸着する多官能性ナノ粒子製剤の開発と疾患治療への応用2022
- Author(s)
  小出裕之
- Organizer
  日本薬剤学会第37年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K25211
[Presentation] 消化管で標的分子を吸着する機能性ナノ粒子開発2022
- Author(s)
  小出裕之
- Organizer
  第27回創剤フォーラム若手研究会
- Invited
- Data Source
  KAKENHI-PROJECT-23K25211
[Presentation] 敗血症治療を可能とする合成高分子ナノ粒子開発2022
- Author(s)
  小出裕之
- Organizer
  第17回ナノ・バイオメディカル学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19384
[Presentation] 血液中で標的分子を中和するポリマーリガンド修飾リポソームの開発2022
- Author(s)
  小出裕之、星野友、奥直人、浅井知浩
- Organizer
  第71回高分子討論会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19384
[Presentation] 経口投与されたポリマーナノ粒子の体内動態に影響を与える因子の模索2022
- Author(s)
  安野豪、小出裕之、米澤正、浅井知浩
- Organizer
  第71回高分子討論会
- Data Source
  KAKENHI-PLANNED-22H05051
[Presentation] 生体内で標的分子を吸着する多官能性ナノ粒子製剤の開発と疾患治療への応用2022
- Author(s)
  小出裕之
- Organizer
  日本薬剤学会第37年会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19384
[Presentation] 血液中で標的分子を中和するポリマーリガンド修飾リポソームの開発2022
- Author(s)
  小出裕之、星野友、奥直人、浅井知浩
- Organizer
  第71回高分子討論会
- Invited
- Data Source
  KAKENHI-PROJECT-23K25211
[Presentation] 消化管で標的分子を吸着する機能性ナノ粒子開発2022
- Author(s)
  小出裕之
- Organizer
  第27回創剤フォーラム若手研究会
- Invited
- Data Source
  KAKENHI-PLANNED-22H05051
[Presentation] 消化管で標的分子を吸着するナノ掃除機の開発2022
- Author(s)
  小出裕之
- Organizer
  第2回BVAバイオインターフェース
- Invited
- Data Source
  KAKENHI-PROJECT-23K25211
[Presentation] 消化管で標的分子を吸着する機能性ナノ粒子開発2022
- Author(s)
  小出裕之
- Organizer
  第27回創剤フォーラム若手研究会
- Invited
- Data Source
  KAKENHI-ORGANIZER-22H05047
[Presentation] 血液中で標的分子を中和するポリマーリガンド修飾リポソームの開発2022
- Author(s)
  小出裕之、星野友、奥直人、浅井知浩
- Organizer
  第71回高分子討論会
- Invited
- Data Source
  KAKENHI-ORGANIZER-22H05047
[Presentation] ポリマーナノ粒子の細胞への取り込み量と排泄量の関係2022
- Author(s)
  佐藤慶次朗、小出裕之、山口和馬、浅井知浩
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-23K25211
[Presentation] 経口投与されたポリマーナノ粒子の体内動態に影響を与える因子の模索2022
- Author(s)
  安野豪、小出裕之、米澤正、浅井知浩
- Organizer
  第71回高分子討論会
- Data Source
  KAKENHI-PROJECT-23K25211
[Presentation] 血液中で標的分子を中和するポリマーリガンド修飾リポソームの開発2022
- Author(s)
  小出裕之、星野友、奥直人、浅井知浩
- Organizer
  第71回高分子討論会
- Invited
- Data Source
  KAKENHI-PLANNED-22H05051
[Presentation] 血液中で標的分子を吸着・中和するナノ粒子開発と疾患治療への応用2022
- Author(s)
  小出裕之
- Organizer
  生体適合化学の進歩インタラクティブフォーラム（ABC-InFO）
- Invited
- Data Source
  KAKENHI-PLANNED-22H05051
[Presentation] 生体内で標的分子を吸着する多官能性ナノ粒子製剤の開発と疾患治療への応用2022
- Author(s)
  小出裕之
- Organizer
  日本薬剤学会第37年会
- Invited
- Data Source
  KAKENHI-PLANNED-22H05051
[Presentation] 経口投与されたポリマーナノ粒子の体内動態に影響する因子の模索2022
- Author(s)
  安野豪、小出裕之、米澤正、浅井知浩
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PLANNED-22H05051
[Presentation] 温度に応答して標的分子を吸着・放出する多官能性ナノ粒子の開発とがん治療への応用2022
- Author(s)
  山口和馬、小出裕之、齊藤和弘、星野友、奥直人、浅井知浩
- Organizer
  遺伝子・デリバリー研究会第20回夏期セミナー
- Data Source
  KAKENHI-PROJECT-23K25211
[Presentation] 脂凍結融解技術を駆使した核酸・タンパク質送達方法の開発2022
- Author(s)
  小出裕之、米澤正、出羽毅久、奥直人、浅井知浩
- Organizer
  第38回日本DDS学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19384
[Presentation] 消化管で標的分子を吸着するナノ掃除機の開発2022
- Author(s)
  小出裕之
- Organizer
  第2回BVAバイオインターフェース
- Invited
- Data Source
  KAKENHI-PROJECT-22K19384
[Presentation] 生体内で標的分子を吸着する多官能性ナノ粒子製剤の開発と疾患治療への応用2022
- Author(s)
  小出裕之
- Organizer
  日本薬剤学会第37年会
- Invited
- Data Source
  KAKENHI-ORGANIZER-22H05047
[Presentation] 経口投与されたポリマーナノ粒子の体内動態に影響を与える因子の模索2022
- Author(s)
  安野豪、小出裕之、米澤正、浅井知浩
- Organizer
  第71回高分子討論会
- Data Source
  KAKENHI-PROJECT-22K19384
[Presentation] 温度に応答して標的分子を吸着・放出する多官能性ナノ粒子の開発とがん治療への応用2022
- Author(s)
  山口和馬、小出裕之、齊藤和弘、星野友、奥直人、浅井知浩
- Organizer
  遺伝子・デリバリー研究会第20回夏期セミナー
- Data Source
  KAKENHI-PROJECT-22K19384
[Presentation] 凍結融解技術を駆使した核酸・タンパク質送達方法の開発2022
- Author(s)
  小出裕之、米澤正、出羽毅久、奥直人、浅井知浩
- Organizer
  第38回日本DDS学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K25211
[Presentation] 消化管で標的分子を吸着するナノ掃除機の開発2022
- Author(s)
  小出裕之
- Organizer
  第2回BVAバイオインターフェース
- Invited
- Data Source
  KAKENHI-ORGANIZER-22H05047
[Presentation] ポリマーナノ粒子の細胞への取り込み量と排泄量の関係2022
- Author(s)
  佐藤慶次朗、小出裕之、山口和馬、浅井知浩
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PLANNED-22H05051
[Presentation] 標的毒素を中和する生分解性の解毒剤開発2022
- Author(s)
  齋藤海斗、小出裕之、丸橋春日、浅井知浩
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-23K25211
[Presentation] 消化管で標的分子を吸着する機能性ナノ粒子開発2022
- Author(s)
  小出裕之
- Organizer
  第27回創剤フォーラム若手研究会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19384
[Presentation] 敗血症治療を可能とする合成高分子ナノ粒子開発2022
- Author(s)
  小出裕之
- Organizer
  第17回ナノ・バイオメディカル学会大会
- Invited
- Data Source
  KAKENHI-ORGANIZER-22H05047
[Presentation] 経口投与されたポリマーナノ粒子の体内動態に影響する因子の模索2022
- Author(s)
  安野豪、小出裕之、米澤正、浅井知浩
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-23K25211
[Presentation] 温度に応答して標的分子を吸着・放出する多官能性ナノ粒子の開発とがん治療への応用2022
- Author(s)
  山口和馬、小出裕之、齊藤和弘、星野友、奥直人、浅井知浩
- Organizer
  遺伝子・デリバリー研究会第20回夏期セミナー
- Data Source
  KAKENHI-PLANNED-22H05051
[Presentation] 温度に応答して標的分子を吸着・放出する多官能性ナノ粒子の開発とがん治療への応用2022
- Author(s)
  山口和馬、小出裕之、齊藤和弘、星野友、奥直人、浅井知浩
- Organizer
  遺伝子・デリバリー研究会第20回夏期セミナー
- Data Source
  KAKENHI-ORGANIZER-22H05047
[Presentation] 消化管で標的分子を吸着するナノ掃除機の開発2022
- Author(s)
  小出裕之
- Organizer
  第2回BVAバイオインターフェース
- Invited
- Data Source
  KAKENHI-PLANNED-22H05051
[Presentation] 敗血症治療を可能とする合成高分子ナノ粒子開発2022
- Author(s)
  小出裕之
- Organizer
  第17回ナノ・バイオメディカル学会大会
- Invited
- Data Source
  KAKENHI-PLANNED-22H05051
[Presentation] 多官能性ポリマーナノ粒子の敗血症治療への応用2021
- Author(s)
  小出裕之、星野　友、奥　直人、シェアケネス、浅井知浩
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] Design of synthetic polymer nanoparticle for sepsis therapy2021
- Author(s)
  Hiroyuki Koide, Yu Hoshino, Naoto Oku, Tomohiro Asai, Kenneth J,Shea
- Organizer
  Serendipity Symposium 2020
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 凍結融解技術を駆使したリポソームによるタンパク質の細胞内送達2021
- Author(s)
  平田真也、小出裕之、落合広樹、鈴木ひかる、出羽毅久、奥　直人、浅井知浩
- Organizer
  第67回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 生体内で標的毒素を中和するポリマーリガンド修飾リポソームの開発2021
- Author(s)
  山内郁実、小出裕之、星野友、奥直人、浅井知浩
- Organizer
  第65回高分子討論会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] ynthetic polymer nanoparticles that release toxic peptides below lower critical solution temperature for cancer therapy2021
- Author(s)
  Hiroyuki Koide, Kazuhiro Saito, Keiichi Yoshimatsu, Yu Hoshino, Naoto Oku, Kenneth J. Shea, Tomohiro Asai
- Organizer
  Pacifichem
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 温度に応答して標的分子を吸着・放出するナノゲル粒子の開発とがん治療応用2021
- Author(s)
  安野　豪、小出裕之、齊藤和弘、星野　友、シアケネス、奥　直人、米澤　正、浅井知浩
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 標的分子を吸着し中和する多官能性リポソームの開発2021
- Author(s)
  鈴木ひかる、小出裕之、平野覚士、井出貴文、濱島義隆、奥直人、浅井知浩
- Organizer
  第65回高分子討論会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 生体内で標的毒素を中和するポリマー結合PEG修飾リポソームの開発2021
- Author(s)
  岡本卓巳、小出裕之、山内郁実、星野　友、奥　直人、浅井知浩
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] Design of a synthetic polymer nanoparticle that captures and neutralizes target molecules in the body2021
- Author(s)
  Hiroyuki Koide, Hoshino Yu, Oku Naoto, Shea Kenneth, Asai Tomohiro
- Organizer
  第65回高分子討論会日韓ジョイントシンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 温度に応答して標的分子を吸着・放出するナノゲル粒子を用いたがん治療研究2021
- Author(s)
  齋藤和弘、小出裕之、星野友、奥直人、浅井知浩
- Organizer
  第65回高分子討論会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 血液中で標的分子を吸着して中和する多官能性リポソームの開発2021
- Author(s)
  小出裕之
- Organizer
  第29回日本血液代替物学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 温度に応答して標的ペプチドを吸着・放出する合成高分子ナノ粒子の開発とがん治療応用2021
- Author(s)
  小出裕之、齋藤和弘、星野友、Shea Kenneth、奥直人、浅井知浩
- Organizer
  第70回高分子討論会
- Invited
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 凍結融解技術を用いたタンパク質内封リポソームの調製と細胞内送達2021
- Author(s)
  落合広樹、小出裕之、鈴木ひかる、出羽毅久、奥直人、浅井知浩
- Organizer
  第36回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 標的分子を吸着してその機能を中和する合成高分子ナノ粒子「プラスチック抗体」開発2021
- Author(s)
  小出裕之、星野友、三浦佳子、シェアケネス、奥直人、浅井知浩
- Organizer
  日本薬剤学会第35年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] Development of polymer nanoparticles adsorbing α-glucosidase for diabetes treatment2019
- Author(s)
  Ayaka Masuda, Hiroyuki Koide, Hiromichi Egami,Yoshitaka Hamashima, Naoto Oku, Tomohiro asai
- Organizer
  ACS meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 敗血症治療に向けた多官能性ポリマーナノ粒子の開発2019
- Author(s)
  小出裕之、星野友、 Shea Kenneth J.、奥直人、浅井知浩
- Organizer
  第29回バイオ・高分子シンポジウム
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] Development of a plastic antibody that captures vascular endothelial growth factor (VEGF) for anticancer therapy2019
- Author(s)
  Hiroyuki Koide, Yu Hoshino, Yuri Noshimura, Yoshiko Miura, Naoto Oku, and Kenneth J Shea, Tomohiro Asai
- Organizer
  ACS meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] Design of multi-functionalized liposome for adsorbing and neutralizing target molecules in vivo2019
- Author(s)
  Satoshi Hirano, Hiroyuki Koide, Takahumi Ide, Yoshitaka Hamashima, Naoto Oku, Tomohiro Asai
- Organizer
  ACS meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] ペプチドを可逆的に吸着・放出する温度応答性ナノゲル粒子の生体内応用2019
- Author(s)
  齋藤和弘、小出裕之、星野友、奥直人、浅井知浩
- Organizer
  第29回バイオ・高分子シンポジウム
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] タンパク質の細胞内送達を可能にする多官能性リポソームの開発2019
- Author(s)
  鈴木ひかる、小出裕之、菱木麻美、江上寛通、橋本博、濱島　義隆、出羽毅久、奥直人、浅井知浩
- Organizer
  日本薬剤学会第34年会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 温度に応答してペプチドを吸着・放出するナノゲル粒子の生体内利用に向けた検討2019
- Author(s)
  齋藤和弘、小出裕之、星野友、Shea Kenneth J.、奥直人、浅井知浩
- Organizer
  第35回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 敗血症治療に向けた合成高分子ナノ粒子の開発2019
- Author(s)
  小出裕之、星野友、奥直人、浅井知浩
- Organizer
  第 65 回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 生体内で標的毒素を中和するポリマー修飾リポソームの開発2019
- Author(s)
  山内郁実、小出裕之、星野友、奥直人、浅井知浩
- Organizer
  日本薬剤学会第34年会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 慢性腎臓病の進行抑制を指向したインドール吸着ポリマーナノ粒子の創製2018
- Author(s)
  沖嶋杏奈、小出裕之、星野友、江上寛通、濱島義隆、浅井知浩、奥直人
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K14519
[Presentation] 生体内で標的毒素を中和するリポソーム人工抗体の開発2018
- Author(s)
  小出裕之、土田大貴、仲本正彦、沖嶋杏奈、星野友、奥直人、浅井知浩
- Organizer
  日本生化学会中部支部第82回例会・シンポジウム
- Data Source
  KAKENHI-PROJECT-17K14519
[Presentation] 敗血症治療に向けた多官能性ポリマーナノ粒子の開発2018
- Author(s)
  小出裕之、星野友、SHEA Kenneth J、奥直人
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K14519
[Presentation] 慢性腎臓病の進行抑制に向けたインドール吸着ポリマーナノ粒子の創製2018
- Author(s)
  沖嶋杏奈、小出裕之、星野　友、江上寛通、濱島義隆、奥　直人、浅井知浩
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-17K14519
[Presentation] 脳虚血再灌流障害治療へ向けた HMGB-1 結合ポリマーナノ粒子の設計2018
- Author(s)
  沖嶋杏奈，小出裕之，清川千秋，星野友，三浦佳子，Kenneth J. SHEA，奥直人，浅井知浩
- Organizer
  日本薬学会東海支部合同学術大会2018
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] Rational design of synthetic polymer nanoparticles that specifically adsorb a toxic molecule2018
- Author(s)
  Anna Okishima, Hiroyuki Koide, Yu Hoshino, Naoto Oku, Tomohiro Asai
- Organizer
  NANODDS 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14519
[Presentation] 生体内で標的生体高分子を吸着するPEG修飾ポリマーナノ粒子の設計2017
- Author(s)
  林直希、小出裕之、有泉早紀、清川千秋、土田大貴、沖嶋杏奈、香門悠里、星野友、Kenneth J. Shea、奥直人
- Organizer
  第33回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-16K15111
[Presentation] 消化管内でインドールを吸着するポリマーナノ粒子の開発2017
- Author(s)
  沖島杏奈、小出裕之、星野友、江上寛通、濱島義隆、奥直人
- Organizer
  第66回高分子討論会
- Data Source
  KAKENHI-PROJECT-17K14519
[Presentation] 敗血症治療に向けたPEG含有ポリマーナノ粒子の開発2017
- Author(s)
  林直希、小出裕之、沖島杏奈、星野友、シェアケネスジェイ、奥直人
- Organizer
  第66回高分子討論会
- Data Source
  KAKENHI-PROJECT-16K15111
[Presentation] Development of polymer nanoparticles with affinity to a vascular endothlial growth factor for cancer therapy2017
- Author(s)
  H. Koide, S. Ariizumi, Y. Hoshino, Y. Miura, S.J. Kenneth, N. Oku
- Organizer
  American Association of Pharmaceutical Scientists Meeting and Exposition
- Data Source
  KAKENHI-PROJECT-16K15111
[Presentation] Development of long-circulating polymer nanoparticles for sepsis treatment.2017
- Author(s)
  N. Hayashi, H. Koide, A. Okishima, Y. Kamon, Y. Hoshino, K.J. Shea, N. Oku
- Organizer
  American Association of Pharmaceutical Scientists Meeting and Exposition
- Data Source
  KAKENHI-PROJECT-16K15111
[Presentation] VEGFを吸着し中和する多官能性合成ポリマーナノ粒子を用いたがん治療2017
- Author(s)
  小出裕之、有泉早紀、沖嶋杏奈、星野友、三浦佳子、Kenneth J. Shea、奥直人
- Organizer
  第33回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-16K15111
[Presentation] がん治療に向けたプラスチック人工抗体の開発2017
- Author(s)
  小出裕之、有泉早紀、星野友、三浦佳子、Kenneth J. Shea、奥直人：
- Organizer
  第81回日本生化学会中部支部例会・シンポジウム
- Data Source
  KAKENHI-PROJECT-16K15111
[Presentation] Usefulness of liposomal neuro-protectants for the treatment of ischemic stroke2017
- Author(s)
  Naoto Oku, Tatsuya Fukuta, Hiroyuki Koide, Kosuke Shimizu, Tomohiro Asai
- Organizer
  Liposome Advances Progress in Drug and Vaccine Delivery
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] Combination therapy with liposomal fasudil and tissue plasminogen activator for ischemic stroke treatment2017
- Author(s)
  Yosuke Yanagida, Tatsuya Fukuta, Tomohiro Asai, Kosuke Shimizu, Hiroyuki Koide, Naoto Oku:
- Organizer
  Liposomes Advances Progress in Drug and Vaccine Delivery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] VEGFと結合して中和する多官能性ポリマーナノ粒子の開発とがん治療へ応用2017
- Author(s)
  小出裕之、有泉早紀、星野友、三浦佳子、シェアケネス、奥直人
- Organizer
  第66回高分子討論会
- Data Source
  KAKENHI-PROJECT-16K15111
[Presentation] 標的高分子を吸着しその機能を中和する合成ポリマーナノ粒子の開発と難治性疾患治療への応用2017
- Author(s)
  小出裕之
- Organizer
  第11回QCM研究会
- Data Source
  KAKENHI-PROJECT-16K15111
[Presentation] Multifunctional polymer-modified liposomes that capture and neutralize toxic protein, histones.2016
- Author(s)
  48.Hiroki Tsuchida, Hiroyuki Koide, Masahiko Nakamoto, Anna Okishima, Saki Ariizumi, Chiaki Kiyokawa, Tomohiro Asai, Yu Hoshino, Naoto Oku
- Organizer
  International Conference on Nanomedicine and Nanobiotechnoloty
- Place of Presentation
  Paris, France
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-16K15111
[Presentation] 生体内で標的毒素を中和する“リポソーム解毒剤”の開発2016
- Author(s)
  43.土田大貴、小出裕之、仲本正彦、沖嶋杏奈、有泉早紀、清川千秋、星野友、奥直人
- Organizer
  第10回QCM研究会
- Place of Presentation
  東京
- Year and Date
  2016-08-26
- Data Source
  KAKENHI-PROJECT-16K15111
[Presentation] 生体内で標的毒素を中和する脂質ナノ粒子解毒剤“Nano-dotes”の開発2016
- Author(s)
  45.土田大貴、小出裕之、仲本正彦、沖嶋杏奈、有泉早紀、清川千秋、星野友、奥直人
- Organizer
  第25回DDSカンファランス
- Place of Presentation
  静岡
- Year and Date
  2016-09-02
- Data Source
  KAKENHI-PROJECT-16K15111
[Presentation] 生体内で標的毒素を中和するポリマーリガンド修飾脂質ナノ粒子の開発2016
- Author(s)
  59.土田大貴、小出裕之、仲本正彦、沖嶋杏奈、有泉早紀、清川千秋、浅井知浩、星野友、奥直人
- Organizer
  第38回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-16K15111
[Presentation] VEGF結合ポリマーナノ粒子の抗腫瘍新生血管療法への応用2015
- Author(s)
  有泉早紀, 小出裕之, 星野友, 西村優里, 三浦佳子, Kenneth SHEA, 奥直人
- Organizer
  日本薬学会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26
- Data Source
  KAKENHI-PROJECT-26888014
[Presentation] VEGF結合特性を有する多官能性ポリマーナノ粒子の開発とがん治療への応用2014
- Author(s)
  小出裕之
- Organizer
  第3回創剤カンファレンス静岡
- Place of Presentation
  静岡
- Year and Date
  2014-12-12
- Data Source
  KAKENHI-PROJECT-26888014

1. Oku Naoto (10167322)

# of Collaborated Projects: 5 results

# of Collaborated Products: 48 results
2. Hoshino Yu (40554689)

# of Collaborated Projects: 5 results

# of Collaborated Products: 23 results
3. 浅井知浩 (00381731)

# of Collaborated Projects: 4 results

# of Collaborated Products: 43 results
4. 清水広介 (30423841)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. 澤田敏樹 (20581078)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 吉本敬太郎 (60392172)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. Shimada Yasuhito (40378427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ANDO Hidenori (00735524)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 馬渡健一 (70190577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 市原佐保子 (20378326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 三浦佳子 (00335069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 清水太郎 (30749388)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 石田竜弘 (50325271)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 疋田智也 (20600935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 池田潔 (40168125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 米澤正 (50469988)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 水野初 (30457288)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 長尾匡憲 (40904008)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 新井宗仁 (90302801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 寺岡文照 (10389108)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 浅井章良 (60381737)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 紅林佑希 (90751983)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 福田達也 (90805160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Koide Hiroyuki 小出 裕之

KOIDE Hiroyuki 小出 裕之

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がん治療を可能とする精密高分子医薬の開発Principal Investigator

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高機能細胞外小胞の生物学的機能解析とがん治療法の開発Principal Investigator

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Exploration of highly functional exosomes using a continuous media recovery system and its application to drug deliveryPrincipal Investigator

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Polymer evolution for medical applicationPrincipal Investigator

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Development of biomimetic nano-antibody that neutralizes target molecules in blood for cancer therapyPrincipal Investigator

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Development of plastic antibodies that inhibit intestinal absorption of target moleculesPrincipal Investigator

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Design of Synthetic Polymer Nanoparticles Specifically Capturing Indole for improvement of uremia symptomPrincipal Investigator

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Koide Hiroyuki 小出裕之

KOIDE Hiroyuki 小出裕之