Miyake Noriko 三宅紀子

… Alternative Names

MIYAKE NORIKO 三宅紀子

MIYAKE Noriko 三宅紀子

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Researcher Number	00421206
Other IDs
Affiliation (Current)	2025: 日本医科大学, 医学部, テクニカル・スタッフ
Affiliation (based on the past Project Information) *help	2018 – 2024: 日本医科大学, 医学部, テクニカルスタッフ 2017: 日本医科大学, 医学部, その他 2016: 日本医科大学, 医学部, テクニカルスタッフ 2012 – 2015: 日本医科大学, 医学部, その他 2010: Nippon Medical School, 医学部, テクニカルサポートスタッフ 2008 – 2009: Nippon Medical School, 医学部, 研究生 2006 – 2007: 日本医科大学, 医学部, 技術主査補
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics / Human genetics
Keywords	Principal Investigator 異染性白質ジストロフィー / ライソゾーム病 / アデノ随伴ウイルス / 遺伝子治療 / リソゾーム病 / 遺伝子細胞治療 / ゲノミクス / マイクログリア / AAV vector / 中枢神経病変 … More / 血液脳関門 / 異染性白質ジストロフィ－ / アデノ随伴ウイルスベクター / 脳神経病変 / 新生児治療 / レトロウイルスベクター / 脳神経細胞 / 骨髄移植 / HoxB4 / 先天異常学 / 遺伝 / 脳神経疾患 / 遺伝子 / 新生時 / 神経変性 / AAVベクター Less

異染性白質ジストロフィーにおけるマイクログリアの機能解明に基づく治療法開発Principal Investigator
- Principal Investigator
  
  三宅紀子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Nippon Medical School
異染性白質ジストロフィーの病態と治療におけるマイクログリアの機能解析Principal Investigator
- Principal Investigator
  
  三宅紀子
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Nippon Medical School
Development of a novel therapy (gene therapy) for metachromatic leukodystrophyPrincipal Investigator
- Principal Investigator
  
  Miyake Noriko
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Nippon Medical School
Development a novel gene therapy for Lysosomal disease with neurological disordersPrincipal Investigator
- Principal Investigator
  
  MIYAKE NORIKO
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nippon Medical School
Development of novel gene therapy for CNS disorders of lysosomal diseasesPrincipal Investigator
- Principal Investigator
  
  MIYAKE NORIKO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nippon Medical School
Development of novel bone marrow transplantation for treatment of CNS disorders in lysosomal disease.Principal Investigator
- Principal Investigator
  
  MIYAKE Noriko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nippon Medical School
リソゾーム病の神経病変を標的とした新規遺伝子治療の開発Principal Investigator
- Principal Investigator
  
  三宅紀子
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human genetics
- Research Institution
  Nippon Medical School

[Book] Neonatal Gene Therapy for Inherited Disorders. Selected Topics in Neonatal Care.2018
- Author(s)
  Miyake K, Miyake N, Shimada T.
- Total Pages
  9
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-15K09604
[Book] Neonatal Gene Therapy for Inherited Disorders. Selected Topics in Neonatal Care.2018
- Author(s)
  Miyake K, Miyake N, Shimada T.
- Total Pages
  9
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-18K07859
[Book] Gene Therapy - Principles and Challenges2015
- Author(s)
  Koichi Miyake, Noriko Miyake and Takashi Shimada
- Total Pages
  208
- Publisher
  INTEC
- Data Source
  KAKENHI-PROJECT-15K09604
[Book] Novel gene therapy approaches2013
- Author(s)
  Miyake K, Shimada T.
- Total Pages
  440
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-24591529
[Book] 医歯2011
- Author(s)
  三宅紀子
- Publisher
  薬出版株式会社
- Data Source
  KAKENHI-PROJECT-20591234
[Book] 医学のあゆみ2011
- Author(s)
  三宅紀子, 他
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-20591234
[Journal Article] 異染性白質ジストロフィー（MLD）に対する遺伝子治療2023
- Author(s)
  三宅　紀子
- Journal Title
  
  日医大医会誌
  
  Volume: 19 Pages: 224-228
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07781
[Journal Article] 2.Treatment of adult metachromatic leukodystrophy model mice using intrathecal administration of type 9 AAV vector encoding arylsulfatase A.2021
- Author(s)
  Miyake N, Miyake K, Sakai A, Yamamoto M, Suzuki H, Shimada T.
- Journal Title
  
  Sci Rep.
  
  Volume: 11 Issue: 1
- DOI
  10.1038/s41598-021-99979-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07859, KAKENHI-PROJECT-21K07781
[Journal Article] A new method for in vivo targeted gene transfer into oligodendrocytes using adenoviral and HIV vectors.2021
- Author(s)
  1.Miyake K, Miyake N and Shimada T.
- Journal Title
  
  Biomedical J. of Sci. & Tec. Res.
  
  Volume: 3 Issue: 3 Pages: 31379-31385
- DOI
  10.26717/bjstr.2021.39.006306
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07859
[Journal Article] 1.Treatment with bone maturation and average lifespan of HPP model mice by AAV8-mediated neonatal gene therapy via single muscle injection.2021
- Author(s)
  Matsumoto T, Miyake K, Miyake N, Iijima O, Adachi K, Narisawa S, Millan JL, Orimo H, Shimada T.
- Journal Title
  
  Mol Ther Methods Clin Dev.
  
  Volume: 22 Pages: 330-337
- DOI
  10.1016/j.omtm.2021.06.006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07859
[Journal Article] 1.TERT and TERC mutations detected in cryptic dyskeratosis congenita suppress telomerase activity.2020
- Author(s)
  Terada K, Miyake K, Yamaguchi H, Miyake N, Yamanaka K, Kojima S, Ito E, Inokuchi K, Okada T.
- Journal Title
  
  Int J Lab Hematol.
  
  Volume: - Issue: 3 Pages: 316-321
- DOI
  10.1111/ijlh.13176
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07859
[Journal Article] 2.Tbx6 induces cardiomyocyte proliferation in postnatal and adult mouse hearts.2019
- Author(s)
  Haginiwa S, Sadahiro T, Kojima H, Isomi M, Tamura F, Kurotsu S, Tani H, Muraoka N, Miyake N, Miyake K, Fukuda K, Ieda M.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 513 Issue: 4 Pages: 1041-1047
- DOI
  10.1016/j.bbrc.2019.04.087
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07859, KAKENHI-PROJECT-18K08114, KAKENHI-PROJECT-19K22613, KAKENHI-PROJECT-18J21479, KAKENHI-PROJECT-17K19678, KAKENHI-PROJECT-18K15861, KAKENHI-PROJECT-17H04179
[Journal Article] MicroRNA cluster miR-17-92 regulates multiple functionally related voltage-gated potassium channels in chronic neuropathic pain2017
- Author(s)
  Sakai Atsushi、Saitow Fumihito、Maruyama Motoyo、Miyake Noriko、Miyake Koichi、Shimada Takashi、Okada Takashi、Suzuki Hidenori
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1 Pages: 16079-16079
- DOI
  10.1038/ncomms16079
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09604, KAKENHI-PROJECT-16K10986, KAKENHI-PROJECT-16K15340, KAKENHI-PROJECT-17K16758, KAKENHI-PROJECT-26293328, KAKENHI-PROJECT-16H05461, KAKENHI-PROJECT-26461596
[Journal Article] Improved Intravitreal AAV-Mediated Inner Retinal Gene Transduction after Surgical Internal Limiting Membrane Peeling in Cynomolgus Monkeys.2017
- Author(s)
  Takahashi K, Igarashi T, Miyake K, Kobayashi M, Yaguchi C, Iijima O, Yamazaki Y, Katakai Y, Miyake N, Kameya S, Shimada T, Takahashi H, Okada T.
- Journal Title
  
  Mol Ther.
  
  Volume: 4；25 Issue: 1 Pages: 296-302
- DOI
  10.1016/j.ymthe.2016.10.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293328, KAKENHI-PROJECT-15K09604, KAKENHI-PROJECT-26461596
[Journal Article] D816V mutation in the KIT gene activation loop has greater cell-proliferative and anti-apoptotic ability than N822K mutation in core-binding factor acute myeloid leukemia2017
- Author(s)
  Omori Ikuko、Yamaguchi Hiroki、Miyake Koichi、Miyake Noriko、Kitano Tomoaki、Inokuchi Koiti
- Journal Title
  
  Experimental Hematology
  
  Volume: 52 Pages: 56-64.e4
- DOI
  10.1016/j.exphem.2017.05.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09604, KAKENHI-PROJECT-17K09942, KAKENHI-PROJECT-26461596
[Journal Article] Tyrosine triple mutated AAV2-BDNF gene therapy in a rat model of transient IOP elevation2016
- Author(s)
  Igarashi T, Miyake K, Kobayashi M, Kameya S, Fujimoto C, Nakamoto K, Takahashi H, Igarashi T, Miyake N, Iijima O, Hirai Y, Shimada T, Okada T, Takahashi H.
- Journal Title
  
  Mol Vis.
  
  Volume: 16 Pages: 816-826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09604
[Journal Article] Enzyme replacement in the CSF to treat metachromatic leukodystrophy in mouse model using single intracerebroventricular injection of self-complementary AAV1 vector.2015
- Author(s)
  Hironaka K, Yamazaki Y, Hirai Y, Yamamoto M, Miyake N, Miyake K, Okada T, Morita A, Shimada T.
- Journal Title
  
  Sci Rep.
  
  Volume: 18 Issue: 1 Pages: 1-12
- DOI
  10.1038/srep13104
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09604, KAKENHI-PROJECT-26461596, KAKENHI-PROJECT-25460407, KAKENHI-PROJECT-26293328
[Journal Article] Prevention of Lethal Murine Hypophosphatasia by Neonatal Ex Vivo Gene Therapy Using Lentivirally Transduced Bone Marrow Cells.2015
- Author(s)
  Iijima O, Miyake K, Watanabe A, Miyake N, Igarashi T, Kanokoda C, Nakamura-Takahashi A, Kinoshita H, Noguchi T, Abe S, Narisawa S, Millán JL, Okada T, Shimada T.
- Journal Title
  
  Hum Gene Ther.
  
  Volume: 26 Issue: 12 Pages: 801-12
- DOI
  10.1089/hum.2015.078
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09604, KAKENHI-PROJECT-26461596, KAKENHI-PROJECT-25461564
[Journal Article] Mutant ataxin-3 with an abnormally expanded polyglutamine chain disrupts dendritic development and metabotropic glutamate receptor signaling in mouse cerebellar purkinje cells2014
- Author(s)
  Konno A, Shuvaev AN, Miyake N, Miyake K, Iizuka A, Matsuura S, Huda F, Nakamura K, Yanagi S, Shimada T, Hirai H.
- Journal Title
  
  Cerebellum
  
  Volume: 13 Issue: 1 Pages: 29-41
- DOI
  10.1007/s12311-013-0516-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591554, KAKENHI-PUBLICLY-24111545, KAKENHI-PROJECT-24590407, KAKENHI-PROJECT-24591529, KAKENHI-PROJECT-24700394, KAKENHI-PROJECT-24800008, KAKENHI-PROJECT-25640040
[Journal Article] Cyclical mechanical stretch enhances degranulation and IL-4 secretion in RBL-2H3 mast cells2014
- Author(s)
  Komiyama H, Miyake K, Asai K, Mizuno K, Shimada T.
- Journal Title
  
  Cell Biochem Funct.
  
  Volume: 32 Issue: 1 Pages: 70-76
- DOI
  10.1002/cbf.2973
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591554, KAKENHI-PROJECT-24591529
[Journal Article] siRNA Knockdown of Tissue Inhibitor of Metalloproteinase-1 in Keloid Fibroblasts Leads to Degradation of Collagen Type I2014
- Author(s)
  Aoki M, Miyake K, Ogawa R, Dohi T, Akaishi S, Hyakusoku H, Shimada T.
- Journal Title
  
  J Invest Dermatol.
  
  Volume: 134 Issue: 3 Pages: 818-826
- DOI
  10.1038/jid.2013.396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591554, KAKENHI-PROJECT-24591529
[Journal Article] Long-term correction of biochemical and neurological abnormalities in MLD mice model by neonatal systemic injection of an AAV serotype 9 vector.2014
- Author(s)
  Miyake N, Miyake K, Asakawa N, Yamamoto M, Shimada T.
- Journal Title
  
  Gene Ther.
  
  Volume: 印刷中 Issue: 4 Pages: 427-433
- DOI
  10.1038/gt.2014.17
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591529, KAKENHI-PROJECT-26461596
[Journal Article] nhibition of S100A6 induces graft versus leukemia effects in MLL/AF4-positive ALL in human PBMC-SCID mice.2014
- Author(s)
  Tamai.H, Miyake K, Yamaguchi H, Shimada T, Dan K, Inokuchi K.
- Journal Title
  
  Bone Marrow Transplantation
  
  Volume: 49(5) Issue: 5 Pages: 699-703
- DOI
  10.1038/bmt.2014.18
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591412, KAKENHI-PROJECT-24591529, KAKENHI-PROJECT-26461434, KAKENHI-PROJECT-26461596
[Journal Article] Direct comparison of administration routes for AAV8-mediated ocular gene therapy2013
- Author(s)
  Igarashi T, Miyake K, Asakawa N, Miyake N, Shimada T, Takahashi H.
- Journal Title
  
  Curr Eye Res.
  
  Volume: 38 Issue: 5 Pages: 569-577
- DOI
  10.3109/02713683.2013.779720
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591554, KAKENHI-PROJECT-24591529
[Journal Article] miR-7a alleviates the maintenance of neuropathic pain through regulation of neuronal excitability2013
- Author(s)
  Sakai A, Saitow F, Miyake N, Miyake K, Shimada T, Suzuki H.
- Journal Title
  
  Brain
  
  Volume: 136 Issue: 9 Pages: 2738-2750
- DOI
  10.1093/brain/awt191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591554, KAKENHI-PROJECT-24591529, KAKENHI-PROJECT-25460345
[Journal Article] Serotype-independent method of recombinant adeno-associated virus (AAV) vector production and purification.2012
- Author(s)
  Miyake K, Miyake N, Yamazaki Y, Shimada T, Hirai Y.
- Journal Title
  
  J Nippon Med Sch.
  
  Volume: 79 Pages: 394-402
- NAID
  130004057397
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591529
[Journal Article] Global gene transfer into the CNS across the BBB after neonatal systemic delivery of single-stranded AAV vectors.2011
- Author(s)
  Miyake N, Miyake K, Yamamoto M, Hirai Y, Shimada T
- Journal Title
  
  Brain Res. 1389
  
  Pages: 19-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591234
[Journal Article] Global gene transfer into the CNS across the BBB after neonatal systemic delivery of single-stranded AAV vectors.2011
- Author(s)
  Noriko Miyake
- Journal Title
  
  Brain Research
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591234
[Journal Article] Successful treatment of metachromatic leukodystrophy using bone marrow tnsplantation of HoxB4 oerexpressing clls.2010
- Author(s)
  Miyake N, Miyake K, Karlsson S, Shimada T
- Journal Title
  
  Mol. Ther. 18
  
  Pages: 1373-1378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591234
[Journal Article] Successful treatment of metachromatic leukodystrophy using bone marrow transplantation of HoxB4 overexpressing cells.2010
- Author(s)
  Noriko Miyake
- Journal Title
  
  Molecular Therapy
  
  Volume: 18 Pages: 1373-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591234
[Journal Article] Global diffuse distribution in the brain and efficient gene delivery to the dorsal root ganglia by intrathecal injection of adeno-associated viral vector serotype 1.2009
- Author(s)
  Iwamoto N, Watanabe A, Yamamoto M, Miyake N, Kurai T, Teramoto A, Shimada T
- Journal Title
  
  J Gene Med. 11
  
  Pages: 498-505
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591234
[Journal Article] Development of targeted gene transfer into human primary T lymphocytes and macrophages using high-titer recombinant HIV vectors2007
- Author(s)
  Miyake K
- Journal Title
  
  J Biotechnol. 129
  
  Pages: 532-538
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790235
[Journal Article] HIV vector mediated targeted suicide gene therapy for adult T-cell leukemia2007
- Author(s)
  Miyake K
- Journal Title
  
  Gene Ther. 14
  
  Pages: 1662-1667
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790235
[Presentation] 異染性白質ジストロフィーの遺伝子治療2022
- Author(s)
  三宅紀子, 三宅弘一, 酒井真志人, 島田隆
- Organizer
  The 28th Annual Meeting of Japan Society of Gene Therapy
- Invited
- Data Source
  KAKENHI-PROJECT-18K07859
[Presentation] Intravitreal injection of AAV vector in cynomolgus monkeys affects neutralizing antibody titer against AAV in the serum2018
- Author(s)
  Tsutomu Igarashi, Kazuhisa Takahashi, Koichi Miyake, Maika Kobayashi, Chiemi Yaguchi, Noriko Miyake, Shuhei Kameya, Hiroshi Takahashi, Takashi Okada
- Organizer
  The 24th Annual Meeting of Japan Society of Gene Therapy
- Data Source
  KAKENHI-PROJECT-15K09604
[Presentation] Direct comparison between single-stranded and self-complementary type 9 AAV vector to treat adult MLD model mice by intravenous injection2018
- Author(s)
  Noriko Miyake, Koichi Miyake, Motoko Yamamoto, Takashi Shimada, Takashi Okada
- Organizer
  The 2４th Annual Meeting of Japan Society of Gene Therapy
- Data Source
  KAKENHI-PROJECT-18K07859
[Presentation] Direct comparison between single-stranded and self-complementary type 9 AAV vector to treat adult MLD model mice by intravenous injection2018
- Author(s)
  Noriko Miyake, Koichi Miyake, Motoko Yamamoto, Takashi Shimada, Takashi Okada
- Organizer
  The 24th Annual Meeting of Japan Society of Gene Therapy
- Data Source
  KAKENHI-PROJECT-15K09604
[Presentation] Intravitreal injection of AAV vector in cynomolgus monkeys affects neutralizing antibody titer against AAV in the serum2018
- Author(s)
  Tsutomu Igarashi, Kazuhisa Takahashi, Koichi Miyake, Maika Kobayashi, Chiemi Yaguchi, Noriko Miyake, Shuhei Kameya, Hiroshi Takahashi, Takashi Okada
- Organizer
  The 2４th Annual Meeting of Japan Society of Gene Therapy
- Data Source
  KAKENHI-PROJECT-18K07859
[Presentation] Why are scAAV9 vectors able to pass through the BBB but not ssAAV9? ; The difference between the ssAAV9 and scAAV9 vector in transduction of CNS by intravenous injection.2017
- Author(s)
  Noriko Miyake, Koichi Miyake, Motoko Yamamoto, Takashi Shimada, Takashi Okada
- Organizer
  20th Annual Meeting of the American Society of Gene & Cell Therapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09604
[Presentation] Why are scAAV9 vectors able to transduce the CNS but not ssAAV9? ; The difference between the ssAAV9 and scAAV9 vector in transduction of CNS by intravenous injection.2017
- Author(s)
  Noriko Miyake, Koichi Miyake, Motoko Yamamoto, Takashi Shimada, Takashi Okada
- Organizer
  The 23th Annual Meeting of Japan Society of Gene Therapy
- Data Source
  KAKENHI-PROJECT-15K09604
[Presentation] ssAAV vectors are able to pass through the BBB as same as dsAAV2016
- Author(s)
  Noriko Miyake, Koichi Miyake, Motoko Yamamoto, Takashi Shimada, Takashi Okada
- Organizer
  The 22th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  東京
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-15K09604
[Presentation] Successful treatment of neonatal metachromatic leukodystrophy model mice by low dose of self-complementary AAV type 9 vector expressing ASA2016
- Author(s)
  Miyake N, Miyake K, Yamamoto M, Shimada T, Okada T
- Organizer
  19th Annual Meeting of the American Society of Gene & Cell Therapy
- Place of Presentation
  Washington DC)
- Year and Date
  2016-05-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09604
[Presentation] 異染性白質ジストロフィー(MLD)の遺伝子治療基盤研究2015
- Author(s)
  三宅　紀子、三宅　弘一、山本　基子、島田　隆、岡田　尚巳
- Organizer
  第20 回日本ライソゾーム病研究会
- Place of Presentation
  東京(慈恵医科大学）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-15K09604
[Presentation] Successful treatment of neonatal metachromatic leukodystrophy model mice by　 intravenous injection of self-complementary AAV type 9 vector expressing ASA2015
- Author(s)
  Noriko Miyake, Koichi Miyake, Motoko Yamamoto, Takashi Shimada, Takashi Okada
- Organizer
  The 21th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  大阪（国際会議場）
- Year and Date
  2015-07-24
- Data Source
  KAKENHI-PROJECT-15K09604
[Presentation] アデノ随伴ウイルスベクターの脳室内注入による異染性白色ジストロフィーモデルマウスの遺伝子治療2015
- Author(s)
  廣中浩平,山崎吉之,平井幸彦, 山本基子, 三宅紀子, 三宅弘一, 森田明夫, 島田隆, 岡田尚巳
- Organizer
  第20 回日本ライソゾーム病研究会
- Place of Presentation
  東京(慈恵医科大学）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-15K09604
[Presentation] Minimally invasive gene therapy of MLD model mice by intrathecal and intravenous injection of AAV9 vector.2014
- Author(s)
  Noriko Miyake, Koichi Miyake, and Takashi Shimada
- Organizer
  10th WORLDSymposium™ 2014
- Place of Presentation
  San Diego,CA
- Data Source
  KAKENHI-PROJECT-24591529
[Presentation] miR-7aは電位依存性ナトリウムチャネルβ2サブユニットの発現調節により慢性期神経障害性疼痛を緩和する2013
- Author(s)
  坂井　敦、齋藤文仁、三宅紀子、三宅弘一、島田　隆、鈴木秀典
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24591529
[Presentation] Disruption of metabotropic glutamate receptor signaling and rescue through intravascular administration of AAV9 in a mouse model of spinocerebellar ataxia type 3.2013
- Author(s)
  Konno A, Shuavaev AN, Miyake N, Miyake K, Yanagi S, Shimada T, Hirai H.
- Organizer
  The 19th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  Okayama
- Data Source
  KAKENHI-PROJECT-24591529
[Presentation] Long−Term Secretion of Arylsulfatase A without Antibody Formation after AAV Mediated Neonatal Gene Transfer into MLD Model Mice.2013
- Author(s)
  Miyake N, Miyake K, Yamamoto M and Shimada T.
- Organizer
  16th Annual Meeting of the American Society of Gene & Cell Therapy.
- Place of Presentation
  Salt Lake City, Utah
- Data Source
  KAKENHI-PROJECT-24591529
[Presentation] Adeno−Associated Vector (Type 8)−Mediated Expression of siRNA Targeting Vascular Endothelial Growth Factor Efficiently Inhibits Neovascularization in a Murine Choroidal Neovascularization Model.2013
- Author(s)
  Igarashi T, Miyake K, Miyake N, Iijima O, Yaguchi C, Shimada T and Takahashi H.
- Organizer
  16th Annual Meeting of the American Society of Gene & Cell Therapy.
- Place of Presentation
  Salt Lake City, Utah
- Data Source
  KAKENHI-PROJECT-24591529
[Presentation] Robust and cell type-specific transgene expression by applying tetracycline-controlled system to AAV9.2013
- Author(s)
  Yamaguchi T, Konno A, Miyake N, Miyake K, Shimada T, Hirai H.
- Organizer
  The 19th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  Okayama
- Data Source
  KAKENHI-PROJECT-24591529
[Presentation] Tolerance induction to arylsulfatase A by AAV mediated neonatal gene transfer into MLD model mice.2013
- Author(s)
  Miyake N, Miyake K, Yamamoto M and Shimada T.
- Organizer
  The 19th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  Okayama
- Data Source
  KAKENHI-PROJECT-24591529
[Presentation] siRNA Targeting Vascular Endothelial Growth Factor by adeno-associated vector (type 8) efficiently inhibits Neovascularization in a Murine Choroidal Neovascularization Model.2013
- Author(s)
  Igarashi T, Miyake N, Iijima O, Yaguchi C, Shimada T, Takahashi H and Miyake K.
- Organizer
  The 19th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  Okayama
- Data Source
  KAKENHI-PROJECT-24591529
[Presentation] DRG神経におけるmiR-7a過剰発現は神経障害性疼痛を特異的に抑制する2012
- Author(s)
  坂井敦、齋藤文仁、三宅紀子、三宅弘一、島田隆、鈴木秀典
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-24591529
[Presentation] Gene therapy of adult MLD model mice by intrathecal administration of type 9 AAV vector2012
- Author(s)
  Noriko Miyake, Koichi Miyake, Atsushi Sakai, Motoko Yamamoto, Ayumi Endo, Hidenori Suzuki, Takashi Shimada
- Organizer
  15th Annual Meeting of the American Society of Gene & Cell Therapy
- Place of Presentation
  Philadelphia, Pennsylvania
- Data Source
  KAKENHI-PROJECT-24591529
[Presentation] AAV9 mediated gene therapy of MLD model mice2012
- Author(s)
  Noriko Miyake, Koichi Miyake, Atsushi Sakai, Motoko Yamamoto, Ayumi Endo, Hidenori Suzuki, Takashi Shimada
- Organizer
  20th Annual Meeting of the European Society of Gene & Cell Therapy
- Place of Presentation
  Versailles, France
- Data Source
  KAKENHI-PROJECT-24591529
[Presentation] Successful treatment of adult MLD model mice by intrathecal administration of AAV9 vector2012
- Author(s)
  Noriko Miyake, Koichi Miyake, Atsushi Sakai, Motoko Yamamoto, Ayumi Endo, Hidenori Suzuki, Takashi Shimada
- Organizer
  The 18th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  Kumamoto
- Data Source
  KAKENHI-PROJECT-24591529
[Presentation] Gene therapy of adult MLD model mice by intrathecal administration of type 9 AAV vector2012
- Author(s)
  Noriko Miyake, Koichi Miyake, Atsushi Sakai, Motoko Yamamoto, Ayumi Endo, Hidenori Suzuki, Takashi Shimada
- Organizer
  第4回国際ライソゾーム病フォーラム・第17回日本ライソゾーム病研究会
- Place of Presentation
  東京プリンスホテル
- Data Source
  KAKENHI-PROJECT-24591529
[Presentation] Long term correction of biochemical and neurological abnormalities of MLD model mice by systemic neonatal injection of serotype 92010
- Author(s)
  三宅紀子
- Organizer
  American Society of Gene Therapy
- Place of Presentation
  米国・ワシントンDC
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-20591234
[Presentation] Global gene transfer in the CNS and phenotypic correction of MLD model mice by systemic neonatal injection of serotype 9 AAV vector.2010
- Author(s)
  Miyake N, et al
- Organizer
  European Human Genetics Conference
- Place of Presentation
  Gothenburg, Sweden
- Year and Date
  2010-06-14
- Data Source
  KAKENHI-PROJECT-20591234
[Presentation] WIDESPREAD TRANSDUCTIONIN THE CNS AND PHENOTYPIC CORRECTION OF MLD MODEL MICE BY SYSTEMIC NEONATAL INJECTION OF SEROTYPE g AAV VECTOR2010
- Author(s)
  三宅紀子
- Organizer
  The 16th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  栃木
- Year and Date
  2010-07-03
- Data Source
  KAKENHI-PROJECT-20591234
[Presentation] Long term correction of biochemical and neurological abnormalities of MLD model mice by systemic neonatal injection of serotype 9.2010
- Author(s)
  Miyake N, et al
- Organizer
  13th Annual Meeting of the American Society of Gene & Cell Therapy
- Place of Presentation
  Washington, DC
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-20591234
[Presentation] Widespread transduction in the CNS and phenotypic correction of MLD model mice by systemic neonatal injection of serotype9 AAV vector.2010
- Author(s)
  Miyake N, et al
- Organizer
  The 16th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  Tochigi
- Year and Date
  2010-07-03
- Data Source
  KAKENHI-PROJECT-20591234
[Presentation] Global gene transfer in the CNS and phenotypic correction of MLD model mice by systemic neonatal injection of serotype 9 AAV vector2010
- Author(s)
  三宅紀子
- Organizer
  European Human Genetics Conference
- Place of Presentation
  Sweden, Gothenburg
- Year and Date
  2010-06-14
- Data Source
  KAKENHI-PROJECT-20591234
[Presentation] Direct comparison of adeno-associated virus serotypes for global gene transfer into the CNS across the BBB after neonatal systemic delivery2009
- Author(s)
  三宅紀子、三宅弘一, 他3名
- Organizer
  The 15th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  大阪
- Year and Date
  2009-07-09
- Data Source
  KAKENHI-PROJECT-20591234
[Presentation] Adeno associated virus (AAV)-mediated neonatal gene therapy of metachromatic leukodystrophy.2009
- Author(s)
  Miyake N, et al
- Organizer
  59th Annual Meeting of the American Society of Human genetics
- Place of Presentation
  Hawaii
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20591234
[Presentation] Efficient correction of cardiac abnormalities in Fabry mice by AAV type8 mediated systemic gene transfer2009
- Author(s)
  三宅弘一、三宅紀子, 他5名
- Organizer
  The 15th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  大阪
- Year and Date
  2009-07-09
- Data Source
  KAKENHI-PROJECT-20591234
[Presentation] Direct comparison of adeno-associated virus serotypes for global gene transfer into the CNS across the BBB after neonatal systemic delivery2009
- Author(s)
  Miyake N, et al
- Organizer
  The 15th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  Osaka
- Year and Date
  2009-07-09
- Data Source
  KAKENHI-PROJECT-20591234
[Presentation] Adeno-associated virus (AAV) type8 mediated systemic neonatal gene therapy for hypophosphatasia2009
- Author(s)
  松本多絵、三宅紀子, 他5名
- Organizer
  59th Annual Meeting of the American Society of Human genetics
- Place of Presentation
  Hawaii
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20591234
[Presentation] Direct comparison of adeno-associated virus serotypes for global gene transfer into the CNS across the BBB after neonatal systemic delivery2009
- Author(s)
  Miyake N, et al
- Organizer
  The 12th Annual Meeting of American ety of Gene Therapy
- Place of Presentation
  San Diego
- Year and Date
  2009-05-30
- Data Source
  KAKENHI-PROJECT-20591234
[Presentation] Adeno-associated virus (AAV) type-8 mediated systemic neonatal gene therapy for hypophosphatasia2009
- Author(s)
  松本多絵、三宅紀子, 他4名
- Organizer
  The 15th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  大阪
- Year and Date
  2009-07-11
- Data Source
  KAKENHI-PROJECT-20591234
[Presentation] Adeno-associated virus (AAV) mediated neonatal gene therapy of metachromatic leukodystrophy2009
- Author(s)
  三宅紀子、三宅弘一, 他2名
- Organizer
  The 3rd International Symposium of Lysosomal Storage Diseases
- Place of Presentation
  名古屋
- Year and Date
  2009-09-26
- Data Source
  KAKENHI-PROJECT-20591234
[Presentation] Direct comparison of adeno-associated virus serotypes for global gene transfer into the CNS across the BBB after neonatal systemic delivery2009
- Author(s)
  三宅紀子、三宅弘一, 他3名
- Organizer
  12th Annual Meeting of the American Society of Gene & Cell Therapy
- Place of Presentation
  San Diego
- Year and Date
  2009-05-30
- Data Source
  KAKENHI-PROJECT-20591234
[Presentation] Establishment and characterization of a new mouse leukemia model induced by MLL/AF4 fusion protein2009
- Author(s)
  玉井勇人、三宅紀子, 他5名
- Organizer
  51th American Society of Hematology Annual Meeting
- Place of Presentation
  New Orleans
- Year and Date
  2009-12-07
- Data Source
  KAKENHI-PROJECT-20591234
[Presentation] Adeno-associated virus (AAV) mediated neonatal gene therapy of metachromatic leukodystrophy.2009
- Author(s)
  Miyake N, et al
- Organizer
  The 3rd International Symposium of Lysosomal Storage Diseases
- Place of Presentation
  Nagoya
- Year and Date
  2009-09-26
- Data Source
  KAKENHI-PROJECT-20591234
[Presentation] Direct comparison of adeno-associated virus serotypes for global gene transfer into the CNS across the BBB after neonatal systemic delivery2009
- Author(s)
  三宅紀子、三宅弘一, 他3名
- Organizer
  59th Annual Meeting of the American Society of Human genetics
- Place of Presentation
  Hawaii
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20591234
[Presentation] Induction of immunotolerance and sustained expression of ASA by single intra venous injection of AAV vector in neonatal immunocompetent mice.2008
- Author(s)
  三宅紀子
- Organizer
  American Society of Gene Therapy
- Place of Presentation
  米国・ボストン
- Data Source
  KAKENHI-PROJECT-20591234
[Presentation] Therapeutic effects of bone marrow transplantation for metachromatic leukodystrophy using HoxB4 over-expressing cells2007
- Author(s)
  Miyake N
- Organizer
  The 13th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  Nagoya, Japan
- Year and Date
  2007-06-30
- Data Source
  KAKENHI-PROJECT-18790235
[Presentation] Successful Treatment of Adult MLD Model Mice By Intravenous Injection of Self-Complementary Type 9 AAV Vector Expressing ASA
- Author(s)
  Miyake N, Miyake K, Yamamoto M, Shimada T.
- Organizer
  17th Annual Meeting of the American Society of Gene & Cell Therapy
- Place of Presentation
  Washington DC
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-24591529
[Presentation] Trans-BBB gene therapy for metachromatic leukodystrophy using self-complementary type 9 AAV vector
- Author(s)
  Miyake N, Miyake K, Yamamoto M, Okada T, Shimada T.
- Organizer
  The 20th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  東京
- Year and Date
  2014-08-06 – 2014-08-08
- Data Source
  KAKENHI-PROJECT-24591529
[]

1. MIYAKE Koichi (90267211)

# of Collaborated Projects: 4 results

# of Collaborated Products: 74 results
2. 酒井真志人 (40643490)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 岡田尚已

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 岡田浩典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 山口博樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Miyake Noriko 三宅 紀子

MIYAKE NORIKO 三宅 紀子

MIYAKE Noriko 三宅 紀子

Research Projects

Research Products

Co-Researchers

異染性白質ジストロフィーにおけるマイクログリアの機能解明に基づく治療法開発Principal Investigator

Principal Investigator

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異染性白質ジストロフィーの病態と治療におけるマイクログリアの機能解析Principal Investigator

Principal Investigator

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Review Section

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Development of a novel therapy (gene therapy) for metachromatic leukodystrophyPrincipal Investigator

Principal Investigator

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Review Section

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Development a novel gene therapy for Lysosomal disease with neurological disordersPrincipal Investigator

Principal Investigator

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Development of novel gene therapy for CNS disorders of lysosomal diseasesPrincipal Investigator

Principal Investigator

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Development of novel bone marrow transplantation for treatment of CNS disorders in lysosomal disease.Principal Investigator

Principal Investigator

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リソゾーム病の神経病変を標的とした新規遺伝子治療の開発Principal Investigator

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Research Institution

[Book] Neonatal Gene Therapy for Inherited Disorders. Selected Topics in Neonatal Care.2018

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[Book] Neonatal Gene Therapy for Inherited Disorders. Selected Topics in Neonatal Care.2018

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[Book] Gene Therapy - Principles and Challenges2015

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[Book] Novel gene therapy approaches2013

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[Book] 医歯2011

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[Book] 医学のあゆみ2011

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[Journal Article] 異染性白質ジストロフィー（MLD）に対する遺伝子治療2023

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Miyake Noriko 三宅紀子

MIYAKE NORIKO 三宅紀子

MIYAKE Noriko 三宅紀子