KODAMA Tetsuya 兒玉哲也

… Alternative Names

兒玉哲也コダマテツヤ

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Researcher Number	00432443
Other IDs
Affiliation (Current)	2025: 名古屋大学, 創薬科学研究科, 准教授
Affiliation (based on the past Project Information) *help	2012 – 2019: 名古屋大学, 創薬科学研究科, 准教授 2015: 名古屋大学, 大学院創薬科学研究科, 准教授 2014: 大阪大学, 大学院薬学研究科, 助教 2011: 大阪大学, 大学院・薬学研究科, 助教 2007 – 2011: 大阪大学, 薬学研究科, 助教 2008: 大阪大学, 大学院・薬学研究科, 助教 2006: 大阪大学, 薬学研究科, 助手
Review Section/Research Field	Principal Investigator Drug development chemistry / Chemical pharmacy / System genome science Except Principal Investigator Chemistry related to living body / Drug development chemistry / Complex systems
Keywords	Principal Investigator 人工核酸 / 核酸 / 創薬化学 / ヌクレオシド / 有機合成化学 / 核酸医薬 / オリゴヌクレオチド / 有機化学 / 分子認識 / 可視化 … More / 医薬分子設計 / ヌクレオチド / 医薬化学 / 核酸創薬 / 分子設計 / 核酸化学 / 構造制御 / 創薬科学 / 薬学 / アルキル化 / 三重鎖形成核酸 / 複合体化 / メチル化 / 8-OxoG / 機能性核酸 / 三重鎖 / 酸化損傷塩基 / 生体関連物質 / ストレス … More Except Principal Investigator 人工核酸 / 有機化学 / ゲノム創薬 / アンチセンス医薬 / バイオコンジュゲート / アンチセンス核酸 / 核酸医薬 / 有機合成化学 / 発現制御 / 遺伝子 / 転写制御 / 分子認識 / 4重鎖 / 三重鎖 / 核酸 / 遺伝子制御 / 遣伝子制御 / 機能性RNA / レドックス / 光感受性 / 分子スイッチ / DNA / 遺伝子診断 / 遺伝子検出 Less

Study on design of Artificial oligonucleotides based on structural control of sugar and phosphate moieties aiming at biostability and toxicity reductionPrincipal Investigator
- Principal Investigator
  
  Kodama Tetsuya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nagoya University
Scientific research on triplex-forming oligonucleotides aiming at to develop next-generation of medicinesPrincipal Investigator
- Principal Investigator
  
  Kodama Tetsuya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nagoya University
Development of platform technologies for antisense oligonucleotide-based therapeutics by a combination of nucleic acids chemistry and information sciences
- Principal Investigator
  
  Satoshi Obika
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  Osaka University
Study on artificial nucleic acids design based on the glycosidic bond angle controlPrincipal Investigator
- Principal Investigator
  
  KODAMA Tetsuya
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nagoya University
Development of synthetic methodology to supply materials for understanding of physiological system
- Principal Investigator
  
  HARI Yoshiyuki
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Osaka University
Study in chemical methylation of cytosine basePrincipal Investigator
- Principal Investigator
  
  KODAMA Tetsuya
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  System genome science
- Research Institution
  Osaka University
Development of oligonucleotide-based artificial transcription factor based on the higher-order structure of nucleic acids
- Principal Investigator
  
  OBIKA Satoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Osaka University
遺伝子発現の時空間制御を目的とした外部刺激応答性スイッチの開発
- Principal Investigator
  
  OBIKA Satoshi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Chemistry related to living body
- Research Institution
  Osaka University
Development of a Sequence-specific detection probe of damaged nucleobase for noninvasive DNA damage imaging.Principal Investigator
- Principal Investigator
  
  KODAMA Tetsuya
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University
Development of artificial nucleic acid conjugates as base materials for genome-based drug discovery and DNA-based diagnostics
- Principal Investigator
  
  IMANISHI Takeshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Osaka University
DNA配列特異的な8-ヒドロキシグアニンの認識;生きたDNA酸化損傷情報の視覚化Principal Investigator
- Principal Investigator
  
  兒玉哲也
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University

[Book] Therapeutic Oligonucleotides : Methods and Protocols2011
- Author(s)
  Y.Hari, T.Kodama, T.Imanishi, S.Obika
- Publisher
  Humana Press
- Data Source
  KAKENHI-PROJECT-22651076
[Book] Therapeutic Oligonucleotides : Methods and Protocols2011
- Author(s)
  Y.Hari, T.Kodama, T.Imanishi, S.Obika
- Publisher
  Humana Press
- Data Source
  KAKENHI-PLANNED-22136006
[Book] Therapeutic Oligonucleotides : Methods and Protocols2011
- Author(s)
  Y.Hari, T.Kodama, T.Imanishi, S.Obika
- Publisher
  Humana Press
- Data Source
  KAKENHI-PROJECT-21350094
[Journal Article] Recent developments of artificial functional oligo nucleic acids2020
- Author(s)
  Moai Yoshihiro、Kodama Tetsuya
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 61 Issue: 14 Pages: 151708-151708
- DOI
  10.1016/j.tetlet.2020.151708
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08364
[Journal Article] Synthesis of selenomethylene-locked nucleic acids (SeLNA) nucleoside unit bearing an adenine base2019
- Author(s)
  Moai Yoshihiro、Hiroaki Hidekazu、Obika Saoshi、Kodama Tetsuya
- Journal Title
  
  Nucleosides, Nucleotides & Nucleic Acids
  
  Volume: 39 Issue: 1-3 Pages: 131-140
- DOI
  10.1080/15257770.2019.1675169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08364
[Journal Article] Synthesis and Properties of 7-Deazapurine- and 8-Aza-7-deazapurine-Locked Nucleic Acid Analogues: Effect of the Glycosidic Torsion Angle2017
- Author(s)
  Takashi Hara, Tetsuya Kodama, Yumi Takegaki, Kunihiko Morihiro, Kosuke Ramon Ito, and Satoshi Obika
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 82 Issue: 1 Pages: 25-36
- DOI
  10.1021/acs.joc.6b02525
- NAID
  120006220429
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460144
[Journal Article] Wavelength-selective light-triggered strand exchange reaction2016
- Author(s)
  Morihiro K., Kodama T., Mori S., Obika S.
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 14 Issue: 5 Pages: 1555-1558
- DOI
  10.1039/c5ob02369f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249007
[Journal Article] Synthesis and hybridization property of a boat-shaped pyranosyl nucleic acid containing an exocyclic methylene group in the sugar moiety2015
- Author(s)
  Kazuto Mori, Tetsuya Kodama, Satoshi Obika
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 23 Issue: 1 Pages: 33-37
- DOI
  10.1016/j.bmc.2014.11.030
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-12J00514, KAKENHI-PROJECT-24249007
[Journal Article] Photoinduced Changes in Hydrogen Bonding Patterns of 8-Thiopurine Nucleobase Analogues in a DNA Strand.2014
- Author(s)
  K. Morihiro, T. Kodama, S. Mori, S. Obika
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 12 Issue: 15 Pages: 2468-2473
- DOI
  10.1039/c3ob42427h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249007, KAKENHI-PROJECT-24790110
[Journal Article] Quantitative Evaluation of the Improvement in the Pharmacokinetics of a Nucleic Acid Drug Delivery System by Dynamic PET Imaging with 18F-incorporated Oligodeoxynucleotides2014
- Author(s)
  H. Mukai, D. Ozaki, Y. Cui, T. Kuboyama, H. Yamato-Nagata, K. Onoe, M. Takahashi, Y. Wada, T. Imanishi, T. Kodama, S. Obika,* M Suzuki, H. Doi, Y. Watanabe
- Journal Title
  
  J. Controlled Release
  
  Volume: 180 Pages: 92-99
- DOI
  10.1016/j.jconrel.2014.02.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249007, KAKENHI-PROJECT-25242070
[Journal Article] Light-triggered Strand Exchange Reaction Using the Change in the Hydrogen Bonding Pattern of the Nucleobase Analog2014
- Author(s)
  K. Morihiro, T. Kodama, R. Waki, S. Obika
- Journal Title
  
  Chem. Sci.
  
  Volume: 5 Issue: 2 Pages: 744-750
- DOI
  10.1039/c3sc51987b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249007, KAKENHI-PROJECT-24790110
[Journal Article] Selenomethylene Locked Nucleic Acid Enables Reversible Hybridization in Response to Redox Changes2013
- Author(s)
  Kunihiko Morihiro
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 52 Issue: 19 Pages: 5074-5078
- DOI
  10.1002/anie.201300555
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J03275, KAKENHI-PROJECT-24249007, KAKENHI-PROJECT-24790110
[Journal Article] Synthesis and evaluation of novel caged DNA alkylating agents bearing 3, 4-epoxypiperidine structure2012
- Author(s)
  Yuji Kawada, Tetsuya Kodama, Kazuyuki Miyashita, Takeshi Imanishi, Satoshi Obika
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: (in press) Issue: 26 Pages: 5102-5102
- DOI
  10.1039/c2ob25366f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350094
[Journal Article] Synthesis of Selenomethylene-locked Nucleic Acid (SeLNA)-modified Oligonucleotides by Polymerases2012
- Author(s)
  Megan Wheeler
- Journal Title
  
  Chemical Communications
  
  Volume: 48 Issue: 89 Pages: 11020-11022
- DOI
  10.1039/c2cc36464f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J03275, KAKENHI-PROJECT-24249007, KAKENHI-PROJECT-24790110
[Journal Article] Hybridizing ability and nuclease resistance profile of backbone modified cationic phosphorothioate oligonucleotides2012
- Author(s)
  S. M. Abdur Rahman, Takeshi Baba, Tetsuya Kodama, Md. Ariful Islam, Satoshi Obika
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: (in press) Issue: 13 Pages: 4098-4102
- DOI
  10.1016/j.bmc.2012.05.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350094
[Journal Article] Amido-Bridged Nucleic Acids (AmNAs): Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro Antisense Potency2012
- Author(s)
  Aiko Yahara, Ajaya Ram Shrestha, Tsuyoshi Yamamoto, Yoshiyuki Hari, Takashi Osawa, Masaki Yamaguchi, Masaru Nishida, Tetsuya Kodama, Satoshi Obika
- Journal Title
  
  ChemBioChem
  
  Volume: vol.13 Issue: 17 Pages: 2513-2516
- DOI
  10.1002/cbic.201200506
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J00549, KAKENHI-PROJECT-24249007, KAKENHI-PROJECT-24790110
[Journal Article] Benzylidene acetal-type bridged nucleic acids : changes in properties upon cleavage of the bridge triggered by external stimuli2011
- Author(s)
  K. Morihiro, T. Kodama, S. Obika
- Journal Title
  
  Chemistry-A European Journal
  
  Volume: 17 Pages: 7918-7926
- Data Source
  KAKENHI-PROJECT-21350094
[Journal Article] Bridged nucleic acid conjugates at 6'-thiol : synthesis, hybridization properties and nuclease resistances2011
- Author(s)
  Kazuto Mori, Tetsuya Kodama, Takeshi Baba, Satoshi Obika
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 9 Pages: 5272-5279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350094
[Journal Article] Design, synthesis and properties of boat-shaped glucopyranosyl nucleic acid2011
- Author(s)
  Kazuto Mori, Tetsuya Kodama, Satoshi Obika
- Journal Title
  
  Organic Letters
  
  Volume: 13 Pages: 6050-6053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22651076
[Journal Article] Design, synthesis and properties of boat-shaped glucopyranosyl nucleic acid2011
- Author(s)
  Kazuto Mori, Tetsuya Kodama, Satoshi Obika
- Journal Title
  
  Organic Letters
  
  Volume: 13 Pages: 6050-6053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350094
[Journal Article] Cleavage of oligonucleotides containing a P3'→N5' phosphoramidite linkage mediated by single-stranded oligonucleotide templates2011
- Author(s)
  Kosuke R. Ito, Tetsuya Kodama, Futaba Makimura, Noritsugu Hosoki, Tomohisa Osaki, Ayao Orita, Takeshi Imanishi, Satoshi Obika
- Journal Title
  
  Molecules
  
  Volume: 16 Pages: 10695-10708
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350094
[Journal Article] Design, synthesis and properties of boat-shaped glucopyranosyl nucleic acid2011
- Author(s)
  K.Mori, T.Kodama, S.Obika
- Journal Title
  
  Org.Lett.
  
  Volume: 13 Issue: 22 Pages: 6050-6053
- DOI
  10.1021/ol2025229
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22136006
[Journal Article] Bridged nucleic acid conjugates at 6'-thiol : synthesis, hybridization properties and nuclease resistances2011
- Author(s)
  K.Mori, T.Kodama, T.Baba, S.Obika
- Journal Title
  
  Org.Biomol.Chem.
  
  Volume: 9 Issue: 14 Pages: 5272-5279
- DOI
  10.1039/c1ob05469d
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22136006
[Journal Article] Bridged nucleic acid conjugates at 6'-thiol : synthesis, hybridization properties and nuclease resistances2011
- Author(s)
  Kazuto Mori, Tetsuya Kodama, Takeshi Baba, Satoshi Obika
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 9 Pages: 5272-5279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22651076
[Journal Article] A novel bridged nucleoside bearing a conformationally switchable sugar moiety in response to redox changes2010
- Author(s)
  Takeshi Baba, Tetsuya Kodama Kazuto Mori, Takeshi Imanishi, Satoshi Obika
- Journal Title
  
  Chemical Communications
  
  Volume: 46 Pages: 8058-8060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350094
[Journal Article] A novel bridged nucleoside bearing a conformationally switchable sugar moiety in response to redox changes2010
- Author(s)
  Takeshi Baba, Tetsuya Kodama Kazuto Mori, Takeshi Imanishi, Satoshi Obika
- Journal Title
  
  Chemical Communications
  
  Volume: 46 Pages: 8058-8060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22651076
[Journal Article] A novel bridged nucleoside bearing a conformationally switchable sugar moiety in response to redox changes.2010
- Author(s)
  Takeshi Baba, Tetsuya Kodama, 他3名
- Journal Title
  
  Chem.Commun.
  
  Volume: 46 Pages: 8058-8060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22651076
[Journal Article] Design, synthesis, and evaluation of a novel bridgednucleic acid, 2′, 5′ -BNA^ON, with S-type sugarconformation fixed by N-O linkage.2009
- Author(s)
  Te tsuya Kodama
- Journal Title
  
  Tetrahedron 65
  
  Pages: 2116-2123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390030
[Journal Article] Design, Synthesis, and Evaluation of a Novel Bridged Nucleic Acid, 2',5'-BNA ^<ON> with S-type Sugar Conformation Fixed by N-O Linkage2009
- Author(s)
  Tetsuya Kodama, Chieko Matsuo, Hidetsugu Ori, Tetsuya Miyoshi, Satoshi Obika, Kazuyuki Miyashita, Takeshi Imanishi
- Journal Title
  
  Tetrahedron 65
  
  Pages: 2116-2123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390030
[Journal Article] Synthesis of a novel trans-3', 4'-BNA monomer bearing a 4,8-dioxa-5-azabicyclo[5.3.0]decane skeleton2009
- Author(s)
  Tetsuya Kodama
- Journal Title
  
  Heterocycles 79(印刷中)
- NAID
  40016543114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790010
[Journal Article] A Bridged Nucleic Acid, 2',4'-BNA^<COC> : Synthesis of Fully Modified Oligonucleotides Bearing Thymine, 5-Methylcytosine, Adenine and Guanine 2',4'-BNA^<COC> Monomers, and RNA-selective Nucleic Acid Recognition2009
- Author(s)
  Yasunori Mitsuoka, Tetsuya Kodama, Ryo Ohnishi, Yoshiyuki Hari, Takeshi Imanishi and Satoshi Obika
- Journal Title
  
  Nucleic Acids Res 37
  
  Pages: 1225-1238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390030
[Journal Article] Design, Synthesis, and Evaluation of a Novel Bridged Nucleic Acid, 2', 5'-BNAON, with S-type Sugar Conformation Fixed by N-O Linkage.2009
- Author(s)
  Tetsuya Kodama, Chieko Matsuo, Hidetsugu Ori, Tetsuya Miyoshi, Satoshi Obika, Kazuyuki Miyashita, Takeshi Imanishi
- Journal Title
  
  Tetrahedron 65
  
  Pages: 2116-2123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790010
[Journal Article] Synthesis of a Novel trans-3', 4'-BNA Monomer Bearing a 4, 8-Dioxa-5-azabicyclo [5. 3. 0] decane Skeleton.2009
- Author(s)
  Tetsuya Kodama, Kensaku Sugaya, Takeshi Baba, Takeshi Imanishi, Satoshi Obika
- Journal Title
  
  Heterocycles 79
  
  Pages: 873-882
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790010
[Journal Article] Synthesis of Light-responsive Bridged Nucleic Acid and Changes in Affinity with Complementary ssRNA.2009
- Author(s)
  Kunihiko Morihiro, Tetsuya Kodama, Masaru Nishida, Takeshi Imanishi, Satoshi Obika
- Journal Title
  
  ChemBioChem 10
  
  Pages: 1784-1788
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790010
[Journal Article] Design, synthesis, and evaluation of a novel bridged nucleic acid, 2',5'- BNA^<0N>, with S-type sugar conformation fixed by N-O linkage2009
- Author(s)
  Tetsuya Kodama
- Journal Title
  
  Tetrahedron 65
  
  Pages: 2116-2123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790010
[Journal Article] Synthesis and properties of 2 ' -deoxy-trans-3', 4' -BNA with S-type sugar puckering.2009
- Author(s)
  Tetsuya Kodama
- Journal Title
  
  Heterocycles 77
  
  Pages: 1209-1217
- NAID
  40016454354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390030
[Journal Article] Synthesis of a novel trans-3', 4' -BNA monomer bearinga 4, 8-dioxa-5-azabicyclo[5. 3. 0]decane skeleton.2009
- Author(s)
  Tetsuya Kodama
- Journal Title
  
  Heterocycles 79(印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390030
[Journal Article] Synthesis of a Novel trans-3',4'-BNA Monomer Bearing a 4,8-Dioxa-5-azabicyclo-[5.3.0]decane Skeleton2009
- Author(s)
  Tetsuya Kodama, Kensaku Sugaya, Takeshi Baba, Takeshi Imanishi, Satoshi Obika
- Journal Title
  
  Heterocycles 79
  
  Pages: 873-882
- NAID
  40016543114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390030
[Journal Article] Design and chemical synthesis of a 2', 4'-BNA probe for 7,8-dihydro-8-oxoguanine-containing double stranded DNA2008
- Author(s)
  Tetsuya Miyoshi (Tetsuya Kodama)
- Journal Title
  
  Nucleic Acids Symp. Ser 52
  
  Pages: 305-306
- Data Source
  KAKENHI-PROJECT-20790010
[Journal Article] Design and Chemical Synthesis of a 2', 4'-BNA Probe for 7, 8-Dihydro-8-oxoguanine-containing Double Stranded DNA.2008
- Author(s)
  Tetsuya Miyoshi, Tetsuya Kodama, Satoshi Obika, Takeshi Imanishi
- Journal Title
  
  Nucleic Acids Symp. Ser. 52
  
  Pages: 305-306
- Data Source
  KAKENHI-PROJECT-20790010
[Presentation] 修飾アロース骨格を糖部に有する3',6'-結合核酸の合成研究2020
- Author(s)
  石倉大輔, 廣明秀一, 兒玉哲也
- Organizer
  日本薬学会第140回年会
- Data Source
  KAKENHI-PROJECT-17K08364
[Presentation] N4'→P6'ホスホロアミダート結合ヘキシトール核酸の開発研究2019
- Author(s)
  大石和馬、廣明秀一、兒玉哲也
- Organizer
  第6回将来を見据えた生体分子の構造・機能解析から分子設計に関する研究会
- Data Source
  KAKENHI-PROJECT-17K08364
[Presentation] N型に糖部立体配座を制御した2',5'-結合核酸の合成と機能性評価に関する研究2019
- Author(s)
  中野篤志、牧野亜衣、廣明秀一、兒玉哲也
- Organizer
  第6回将来を見据えた生体分子の構造・機能解析から分子設計に関する研究会
- Data Source
  KAKENHI-PROJECT-17K08364
[Presentation] N型立体配座に制御した2'5'-結合核酸の合成と特性評価に関する研究2019
- Author(s)
  中野篤志、牧野亜衣、廣明秀一、兒玉哲也
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K08364
[Presentation] ピラノシド核酸の高機能化によるDNAアナログの創製研究2019
- Author(s)
  石倉大輔、廣明秀一、兒玉哲也
- Organizer
  第6回将来を見据えた生体分子の構造・機能解析から分子設計に関する研究会
- Data Source
  KAKENHI-PROJECT-17K08364
[Presentation] 糖部構造を刷新した人工核酸の設計と合成2019
- Author(s)
  兒玉哲也
- Organizer
  第2回 BINDS 合成勉強会
- Data Source
  KAKENHI-PROJECT-17K08364
[Presentation] 歪んだトランス縮環骨格を糖部骨格とするヌクレオシド類の合成2018
- Author(s)
  兒玉哲也、牧野亜衣、近田達哉、中野篤志、大石和馬、廣明秀一
- Organizer
  第113回有機合成シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08364
[Presentation] Synthetic study of an N3'->P5' phosphoramidate-type nucleic acid2017
- Author(s)
  近田達哉，廣明秀一，兒玉哲也
- Organizer
  第44回国際核酸化学シンポジウム/日本核酸化学会第1回年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08364
[Presentation] オリゴ核酸の創薬研究:化学者の立場からみる問題点とその解決に向けた試み2016
- Author(s)
  兒玉哲也
- Organizer
  第 2 回名古屋大学-ラクオリア創薬シンポジウム
- Place of Presentation
  愛知県名古屋市
- Year and Date
  2016-01-26
- Data Source
  KAKENHI-PROJECT-26460144
[Presentation] 二面角ガンマを固定した2'-5'連結型核酸分子含有オリゴ核酸の合成とその二重鎖、三重鎖核酸の安定性2016
- Author(s)
  牧野亜衣、廣明秀一、兒玉哲也
- Organizer
  日本核酸医薬学会第２回年会
- Place of Presentation
  東京都
- Year and Date
  2016-11-15
- Data Source
  KAKENHI-PROJECT-26460144
[Presentation] Synthesis and hybridization property of a boat-shaped pyranosyl nucleic acid analogue whose nucleobase orientation is similar to that of natural RNA2015
- Author(s)
  Kanagawa T., Mori K., Kodama T., Obika S.
- Organizer
  PACIFICHEM 2015
- Place of Presentation
  米国・ハワイ・ホノルル
- Year and Date
  2015-12-15
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] Synthetic study of 2’,5’-linked oligonucleotides containing the dihedral-angle-γ-locked ribosyl thymine2015
- Author(s)
  牧野亜衣、廣明秀一、兒玉哲也
- Organizer
  The 42nd International Symosium on Nucleic Acids Chemistry
- Place of Presentation
  兵庫県姫路市
- Year and Date
  2015-09-23
- Data Source
  KAKENHI-PROJECT-26460144
[Presentation] 赤血球ヘモグロビンによる薬物送達を目的とした薬物コンジュゲートの開発研究2015
- Author(s)
  近田達哉、廣明秀一、兒玉哲也
- Organizer
  第61回日本薬学会東海支部大会
- Place of Presentation
  名古屋市
- Year and Date
  2015-07-04
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] 赤血球によるオリゴ核酸送達を期待したヘモグロビン親和性化合物結合型オリゴ核酸の合成と評価2015
- Author(s)
  近田達哉、廣明秀一、兒玉哲也
- Organizer
  日本核酸医薬学会第1回年会
- Place of Presentation
  京都市
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] セレノメチレン架橋型ピリミジンヌクレオシドで修飾したアンチセンス分子2015
- Author(s)
  兒玉哲也，百相義大，森廣邦彦，廣明秀一，小比賀聡
- Organizer
  日本核酸医薬学会第1回年会
- Place of Presentation
  京都市
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] 舟形固定した L-リキソースを糖部に有する人工核酸の相補鎖結合親和性 ―塩基の回転角が核酸二重鎖安定性に及ぼす影響―2015
- Author(s)
  金川峻幸、森和土、兒玉哲也、小比賀聡
- Organizer
  第65回日本薬学会近畿支部大会
- Place of Presentation
  大阪府富田林市（大阪大谷大学）
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] Erythrocyte uptake of oligonucleotides conjugated to a hemoglobin-binding compound2015
- Author(s)
  Konda T., Hiroaki H., Kodama T.
- Organizer
  The 42nd International Symosium on Nucleic Acids Chemistry
- Place of Presentation
  姫路市
- Year and Date
  2015-09-23
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] Synthesis and evaluation of Base locked Nucleic Acid (BlNA): the effect of fixing glycosidic torsion angle.2014
- Author(s)
  Hara Takashi, Kodama Tetsuya, Mori Kazuto, Obika Satoshi
- Organizer
  The 41st International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  北九州
- Year and Date
  2014-11-05
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] 3H2型シクロヘキセニル核酸の設計と合成、及び機能性評価2014
- Author(s)
  百相義大、武田修一、松本友治、廣明秀一、小比賀聡、兒玉哲也
- Organizer
  第60回日本薬学会東海支部大会
- Place of Presentation
  鈴鹿
- Year and Date
  2014-07-05
- Data Source
  KAKENHI-PROJECT-26460144
[Presentation] ヌクレオシド・ヌクレオチドならびにオリゴヌクレオチドのメディシナルケミストリー2014
- Author(s)
  兒玉哲也
- Organizer
  中部地区医療・バイオ系シーズ発表会
- Place of Presentation
  ウインクあいち(愛知)
- Year and Date
  2014-12-12
- Data Source
  KAKENHI-PROJECT-24790110
[Presentation] 3H2型シクロヘキセニル核酸の設計と合成、及び機能性評価2014
- Author(s)
  百相義大、武田修一、松本友治、廣明秀一、小比賀聡、兒玉哲也
- Organizer
  第60回日本薬学会東海支部大会
- Place of Presentation
  鈴鹿
- Year and Date
  2014-07-05
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] 架橋型人工核酸(BNA)の核酸医薬への応用2014
- Author(s)
  兒玉哲也
- Organizer
  名古屋大学予防早期医療創成センター第4回ワークショップ
- Place of Presentation
  名古屋大学(愛知)
- Year and Date
  2014-01-29
- Data Source
  KAKENHI-PROJECT-24790110
[Presentation] 架橋型シクロヘキセニル核酸の合成と評価2013
- Author(s)
  百相義大、廣明秀一、小比賀聡、兒玉哲也
- Organizer
  第23回アンチセンスシンポジウム
- Place of Presentation
  徳島大学(徳島)
- Data Source
  KAKENHI-PROJECT-24790110
[Presentation] Selenomethylene Locked Nucleic Acid (SeLNA) Bearing a Purine Base2013
- Author(s)
  Yoshihiro Moai, Tetsuya Kodama, Kunihiko Morihiro, Hidekazu Hiroaki, Satoshi Obika
- Organizer
  The 40th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-24790110
[Presentation] Selenomethylene locked nucleic acid (SeLNA) bearing a purine base2013
- Author(s)
  Yoshihiro Moai, Tetsuya Kodama, Kunihiko Morihiro, Hidekazu Hiroaki, Satoshi Obika
- Organizer
  The 40^<th> international symposium on nucleic acids chemistry
- Place of Presentation
  神奈川大学(神奈川)
- Data Source
  KAKENHI-PROJECT-24790110
[Presentation] Syntheses and properties of nucleic acids having constrained pyranose as the sugar moiety2013
- Author(s)
  Kazuto Mori, Tetsuya Kodama, Satoshi Obika
- Organizer
  The 40^<th> international symposium on nucleic acids chemistry
- Place of Presentation
  神奈川大学(神奈川)
- Data Source
  KAKENHI-PROJECT-24790110
[Presentation] セレノメチレン架橋型人工核酸の開発と酸化還元スイッチへの応用2013
- Author(s)
  森廣邦彦, 兒玉哲也, 肯特夫, 百相義大, Veedu Rakesh.N, 小比賀聡
- Organizer
  日本薬学会　第133年会
- Place of Presentation
  神奈川県横浜市
- Data Source
  KAKENHI-PROJECT-24790110
[Presentation] 架橋型シクロヘキセニル核酸の合成と評価2013
- Author(s)
  百相義大、廣明秀一、小比賀聡、兒玉哲也
- Organizer
  第２３回アンチセンスシンポジウム
- Place of Presentation
  徳島大学（徳島）
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] Syntheses and properties of nucleic acids having constrained pyranose as the sugar moiety2013
- Author(s)
  Kazuto Mori, Tetsuya Kodama, Satoshi Obika
- Organizer
  The 40th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-24790110
[Presentation] Syntheses and properties of nucleic acids having constrained pyranose as the sugar moiety2013
- Author(s)
  Kazuto Mori, Tetsuya Kodama, Satoshi Obika
- Organizer
  The 40th International Symposium on Nucleic Acids Chemistry 2013
- Place of Presentation
  神奈川大学（神奈川）
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] 舟形ピラノース核酸類の合成とその標的結合能2013
- Author(s)
  森和土、兒玉哲也、小比賀聡
- Organizer
  第39回反応と合成の進歩シンポジウム
- Place of Presentation
  九州大学(福岡)
- Year and Date
  2013-11-06
- Data Source
  KAKENHI-PROJECT-24790110
[Presentation] 架橋型シクロヘキセニル核酸の合成と評価2013
- Author(s)
  百相義大、廣明秀一、小比賀聡、兒玉哲也
- Organizer
  第23回アンチセンスシンポジウム
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-24790110
[Presentation] 核酸化学: 核酸医薬創出に向けた新たなコンホメーション固定型人工核酸の開発2013
- Author(s)
  兒玉哲也
- Organizer
  第2回岐阜構造生物学・医学・論理的創薬研究会シンポジウム
- Place of Presentation
  岐阜県岐阜市
- Invited
- Data Source
  KAKENHI-PROJECT-24790110
[Presentation] Selenomethylene Locked Nucleic Acid (SeLNA) Bearing a Purine Base2013
- Author(s)
  Yoshihiro Moai, Tetsuya Kodama, Kunihiko Morihiro, Hidekazu Hiroaki, Satoshi Obika
- Organizer
  The 40th International Symposium on Nucleic Acids Chemistry 2013
- Place of Presentation
  神奈川大学（神奈川）
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] 2',4'-BNA/LNA-プリン塩基類縁体の二重鎖形成能に及ぼす二面角χの影響2013
- Author(s)
  原孝志, 兒玉哲也, 竹垣裕美, 森廣邦彦, 伊藤浩介, 小比賀聡
- Organizer
  日本薬学会　第133年会
- Place of Presentation
  神奈川県横浜市
- Data Source
  KAKENHI-PROJECT-24790110
[Presentation] Synthesis and properties of a nucleic acid bearing boat-shaped pyranose sugar2012
- Author(s)
  Kazuto Mori, Tetsuya Kodama, Satoshi Obika
- Organizer
  13th Tetrahedron Symposium - Asia Edition
- Place of Presentation
  台湾、台北市
- Data Source
  KAKENHI-PROJECT-24790110
[Presentation] Investigation of the factor affecting the duplex-forming ability of boat-shaped glucopyranosyl nucleic acid2012
- Author(s)
  Kazuto Mori, Tetsuya Kodama, Satoshi Obika
- Organizer
  XX International Round Table on Nucleosides, Nucleotides and Nucleic Acids
- Place of Presentation
  カナダ、モントリオール
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] Torsion angle around glycosidic bond on BNA/LNA-purine strongly affects duplex stability2012
- Author(s)
  Tetsuya Kodama, Takashi Hara, Yumi Takegaki, Kunihiko Morihiro, Kosuke Ramon Ito, Obika Satoshi
- Organizer
  The 39th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  愛知県名古屋市
- Data Source
  KAKENHI-PROJECT-24790110
[Presentation] 糖部構造を固定化したグルコピラノシル核酸の合成と構造に関する研究2012
- Author(s)
  兒玉哲也, 森和土, 小比賀聡
- Organizer
  第58回日本薬学会東海支部大会
- Place of Presentation
  静岡県静岡市
- Data Source
  KAKENHI-PROJECT-24790110
[Presentation] Synthesis and hybridization property of oligonucleotides containing 2’,4’-BNA-7-deazaguanine analog.2012
- Author(s)
  Takashi Hara, Yumi Takegaki, Kunihiko Morihiro, Kosuke Ramon Ito, Tetsuya Kodama, Satoshi Obika
- Organizer
  XX International Round Table on Nucleosides, Nucleotides and Nucleic Acids
- Place of Presentation
  カナダ、モントリオール市
- Data Source
  KAKENHI-PROJECT-24790110
[Presentation] Synthesis and properties of a nucleic acid bearing boat-shaped pyranose sugar2012
- Author(s)
  Kazuto Mori, Tetsuya Kodama, Satoshi Obika
- Organizer
  13th Tetrahedron Symposium - Asia Edition
- Place of Presentation
  台湾、台北
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] 光刺激により糖部架橋構築が誘起される人工核酸の開発2012
- Author(s)
  肯特夫, 森廣邦彦, 兒玉哲也, 小比賀聡
- Organizer
  第132回日本薬学会年会
- Place of Presentation
  北海道大学高等教育振興機構(札幌)
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] チミン塩基をもつセレノメチレン架橋型人工核酸の合成と基本的性質2012
- Author(s)
  兒玉哲也, 森廣邦彦, 肯特夫, 百相義大, Veedu Rakesh.N, 小比賀聡
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム 2012
- Place of Presentation
  宮城県仙台市
- Data Source
  KAKENHI-PROJECT-24790110
[Presentation] 光刺激により糖部架橋構築が誘起される人工核酸の開発2012
- Author(s)
  肯特夫, 森廣邦彦, 兒玉哲也, 小比賀聡
- Organizer
  第132回日本薬学会年会
- Place of Presentation
  北海道大学(札幌)
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-21350094
[Presentation] 光刺激により認識塩基が変化するシン配向型非天然核酸塩基の開発2012
- Author(s)
  森廣邦彦, 兒玉哲也, 小比賀聡
- Organizer
  日本化学会第92春季年会
- Place of Presentation
  慶応大学(横浜)
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-21350094
[Presentation] Investigation of the factor affecting the duplex-forming ability of boat-shaped glucopyranosyl nucleic acid2012
- Author(s)
  Kazuto Mori, Tetsuya Kodama, Satoshi Obika
- Organizer
  XX International Round Table on Nucleosides, Nucleotides and Nucleic Acids
- Place of Presentation
  カナダ、モントリオール市
- Data Source
  KAKENHI-PROJECT-24790110
[Presentation] A new entry of thiol-containing nucleic acid monomer for conjugation chemistry2011
- Author(s)
  Tetsuya Kodama, Kazuto Mori, Takeshi Baba, Satoshi Obika
- Organizer
  6th Cambridge Symposium on Nucleic Acids Chemistry and Biology
- Place of Presentation
  Queens' College Cambridge, UK
- Data Source
  KAKENHI-PROJECT-22651076
[Presentation] Cleavage of Oligonucleotides Containing a P3'→N5' Phosphoramidate Linkage Triggered by Duplex Formation2011
- Author(s)
  K.R.Ito, T.Kodama, F.Makimura, N.Hosoki, T.Osaki, A.Orita, T.Imanishi, S.Obika.
- Organizer
  The 38th International Symposium on Nucleic Acid Chemistry (2011ISNAC)
- Place of Presentation
  北海道大学(札幌)
- Data Source
  KAKENHI-PROJECT-21350094
[Presentation] 3,4-エポキシピペリジン骨格を有する配列選択的DNAアルキル化分子の開発2011
- Author(s)
  河田裕治, 兒玉哲也, 宮下和之, 小比賀聡
- Organizer
  第131回日本薬学会年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] Cleavage of Oligonucleotides Containing a P3'→N5' Phosphoramidate Linkage Triggered by Duplex Formation2011
- Author(s)
  Kosuke. R. Ito, Tetsuya Kodama, Futaba Makimura, Noritsugu Hosoki, Tomohisa Osaki, Ayako Orita, Takeshi Imanishi, Satoshi Obika
- Organizer
  The 38th International Symposium on Nucleic Acid Chemistry(2011ISNAC)
- Place of Presentation
  北海道大学(札幌)
- Data Source
  KAKENHI-PROJECT-21350094
[Presentation] A new entry of thiol-containing nucleic acid monomer for conjugation chemistry2011
- Author(s)
  Tetsuya Kodama, Kazuto Mori, Takeshi Baba, Satoshi Obika
- Organizer
  6th Cambridge Symposium on Nucleic Acids Chemistry and Biology
- Place of Presentation
  Queens' College Cambridge, UK
- Data Source
  KAKENHI-PROJECT-21350094
[Presentation] Synthesis and Evaluation of External Stimuli-responsive Bridged Nucleic Acids2011
- Author(s)
  K.Morihiro, T.Kodama, S.Obika
- Organizer
  The 38th International Symposium on Nucleic Acid Chemistry (2011ISNAC)
- Place of Presentation
  北海道大学(札幌)
- Data Source
  KAKENHI-PROJECT-21350094
[Presentation] 光刺激により5-ホルミルピリミジンへと変換される新規人工ヌクレオシドの合成2011
- Author(s)
  浅田安紀子, 兒玉哲也, 小比賀聡
- Organizer
  第131回日本薬学会年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] シアノ基が有する官能基変換の多様性と簡便さに着目したBNA-C-グリコシド類の新たな合成法の開発2011
- Author(s)
  上松由昌, 兒玉哲也, 小比賀聡
- Organizer
  第131回日本薬学会年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] Synthesis and Evaluation of External Stimuli-responsive Bridged Nucleic Acids2011
- Author(s)
  Kunihiko Morihiro, Tetsuya Kodama, Satoshi Obika
- Organizer
  The 38th International Symposium on Nucleic Acid Chemistry(2011ISNAC)
- Place of Presentation
  北海道大学(札幌)
- Data Source
  KAKENHI-PROJECT-21350094
[Presentation] A Novel Bridged Nucleic Acid Containing a Thiol Group in the Bridged Structure : Synthesis, Conjugation with Functional Molecules and Hybridization Properties2010
- Author(s)
  K.Mori, T.Kodama, T.Baba, S.Obika
- Organizer
  第37回国際核酸化学シンポジウム
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] Synthesis and Properties of a Novel Nucleic Acid that Alters Hybridizing Ability Depending on Redox Conditions2010
- Author(s)
  T.Baba, T.Kodama, K.Mori, T.Imanishi, S.Obika
- Organizer
  The International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
- Place of Presentation
  Honolulu, USA
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] 架橋部位にチオール基を有する新規人工核酸の合成とコンジュゲート化への応脚用2010
- Author(s)
  森和土, 兒玉哲也, 馬場武, 小比賀聡
- Organizer
  第60回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] A Novel Bridged Nucleic Acid Containing a Thiol Group in the Bridged Structure : Synthesis, Conjugation with Functional Molecules and Hybridization Properties2010
- Author(s)
  Kazuto Mori, Tetsuya Kodama, Takeshi Baba, Satoshi Obika
- Organizer
  The 37th International Symposium on Nucleic Acid Chemistry
- Place of Presentation
  神奈川・はまぎんホールヴィアマーレ
- Data Source
  KAKENHI-PROJECT-22651076
[Presentation] 外部刺激応答性架橋型人工核酸スイッチの開発2010
- Author(s)
  兒玉哲也, 森廣邦彦, 馬場武, 今西武, 小比賀聡
- Organizer
  第60回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] Synthesis and properties of 2',4'-BNA with 8-aza-7-deazaguanine2010
- Author(s)
  Y.Takegaki, K.Morihiro, T.Kodama, M.Nakatani, S.Obika
- Organizer
  The International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
- Place of Presentation
  Honolulu, USA
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] 架橋部位にチオール基を有する新規人工核酸の合成及びその評価2010
- Author(s)
  森和土, 兒玉哲也, 馬場武, 小比賀聡
- Organizer
  第20回アンチセンスシンポジウム
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] Synthesis and properties of 2', 4'-BNA with 8-aza-7-deazaguanine2010
- Author(s)
  Yumi Takegaki, Kunihiko Morihiro, Tetsuya Kodama, Moeka Nakatani and Satoshi Obika
- Organizer
  The International Chemical Congress of Pacific Basin Societies(PACIFICHEM 2010)
- Place of Presentation
  Honolulu, Hawaii(USA)
- Data Source
  KAKENHI-PROJECT-21350094
[Presentation] 架橋部位にチオール基を有する新規人工核酸の合成とコンジュゲート化への応用2010
- Author(s)
  森和土、兒玉哲也、馬場武、小比賀聡
- Organizer
  第60回日本薬学会近畿支部大会
- Place of Presentation
  大阪・摂南大学
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-22651076
[Presentation] 架橋部位にチオール基を有する新規人工核酸の合成及びその評価2010
- Author(s)
  森和土、兒玉哲也、馬場武、小比賀聡
- Organizer
  第20回アンチセンスシンポジウム
- Place of Presentation
  兵庫・甲南大学
- Data Source
  KAKENHI-PROJECT-22651076
[Presentation] 3-オキサ-4-アザペンチレン架橋構造を有する新しいtrans-3', 4'-BNAの設計と合成2009
- Author(s)
  兒玉哲也、菅谷建作、馬場武、今西武、小比賀聡
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20790010
[Presentation] 次世代核酸系機能素材の創製を目指した高度機能化人工核酸の設計と合成2009
- Author(s)
  兒玉哲也
- Organizer
  第33回大学分析者の会
- Place of Presentation
  大阪
- Year and Date
  2009-07-29
- Data Source
  KAKENHI-PROJECT-20790010
[Presentation] 遺伝子発現の時空間制御を目指した外部刺激応答型人工核酸スイッチの設計と合成2009
- Author(s)
  兒玉哲也
- Organizer
  第59回日本薬学会近畿支部大会
- Place of Presentation
  大阪
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-20655038
[Presentation] 三重鎖形成を基盤とした迅速かつ簡便なSNP分析法2009
- Author(s)
  伊藤浩介、戸水真治、根来佳憲、折田文子、兒玉哲也、今西武、小比賀聡
- Organizer
  遺伝子・デリバリー研究会第9回シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2009-07-11
- Data Source
  KAKENHI-PROJECT-20790010
[Presentation] DNA配列選択的な8-ヒドロキジグアニン検出プローブの創製研究2008
- Author(s)
  兒玉哲也
- Organizer
  第6回次世代を担う有機化学シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20790010
[Presentation] 8-OxoGの配列特異的認識能を有する三重鎖形成人工核酸の開発(2)2008
- Author(s)
  兒玉哲也, 三好哲也, 小比賀聡, 今西武
- Organizer
  第58回日本薬学会近畿支部大会
- Place of Presentation
  兵庫
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-20790010
[Presentation] 8-OxoGの配列特異的認識能を有する三重鎖形成人工核酸の開発(1)2008
- Author(s)
  三好哲也, 兒玉哲也, 小比賀聡, 今西武
- Organizer
  第58回日本薬学会近畿支部大会
- Place of Presentation
  兵庫
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-20790010
[Presentation] Design and Chemical Synthesis of a 2', 4'-BNA Probe for 7, 8-Dihydro-8-oxoguanine-containing Double Stranded DNA2008
- Author(s)
  三好哲也(兒玉哲也)
- Organizer
  Joint symposium of 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and 35th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20790010
[Presentation] DNA配列選択的な8-ヒドロキシグアニン検出プローブの創製研究2008
- Author(s)
  兒玉哲也、三好哲也、小比賀聡、今西武
- Organizer
  第6回次世代を担う有機化学シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20790010
[Presentation] 2,2'一ビスベンズイミダゾール骨格を有した新規蛍光分子の開発とオリゴヌクレオチドラベル化に関する研究2008
- Author(s)
  松山憲司、渡部徹也、兒玉哲也、小比賀聡、宮下和之、今西武
- Organizer
  第三回バイオ関連化学合同シンポジウム2008
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-19390030
[Presentation] 二重鎖DNA中の8-オキソグアニン塩基を選択的に認識する人工核酸プローブ2008
- Author(s)
  兒玉哲也
- Organizer
  第11回生命化学研究会
- Place of Presentation
  群馬
- Data Source
  KAKENHI-PROJECT-20790010
[Presentation] Design and Chemical Synthesis of a 2', 4'-BNA Probe for 7, 8-Dihydro-8-oxoguanine-containing Double Stranded DNA, Joint symposium of 18th International Roundtable on Nucleosides2008
- Author(s)
  Tetsuya Miyoshi, Tetsuya Kodama, Satoshi Obika, Takeshi Imanishi
- Organizer
  Nucleotides and Nucleic Acids and 35th International Symposium on Nucleic Acids Chelistry
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20790010
[Presentation] Synthesis and evaluation of a novel 2', 5'-bridged nucleic acid whose sugar conformation was fixed to S-type by N-O linkage2007
- Author(s)
  兒玉哲也
- Organizer
  第5回国際核酸化学シンポジウム
- Place of Presentation
  東京大学安田講堂
- Data Source
  KAKENHI-PROJECT-18890097
[Presentation] Synthesis andproperties of a 2'-deoxy analogue of trans-3',4'-BNA having an S-type sugar conformation2007
- Author(s)
  兒玉哲也、松尾智恵子、小里英嗣、小比賀聡、宮下和之、今西武
- Organizer
  5th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-19390030
[Presentation] セレノメチレン架橋型人工核酸の開発と酸化還元スイッチへの応用
- Author(s)
  森廣邦彦，兒玉哲也，肯特夫，百相義大，Veedu Rakesh.N，小比賀聡
- Organizer
  日本薬学会　第133年会
- Place of Presentation
  神奈川県横浜市
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] 6,2’‐エタノ架橋型チミジンの合成とその特性評価
- Author(s)
  守屋彩子、廣明秀一、兒玉哲也
- Organizer
  第135回日本薬学会年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460144
[Presentation] 3',5'位間に架橋構造を導入した2'-5'結合人工核酸の合成研究
- Author(s)
  牧野亜衣、廣明秀一、兒玉哲也
- Organizer
  第135回日本薬学会年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460144
[Presentation] 架橋型人工核酸（BNA）の核酸医薬への応用
- Author(s)
  兒玉哲也
- Organizer
  名古屋大学予防早期医療創成センター第４回ワークショップ
- Place of Presentation
  名古屋大学（愛知）
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] Synthesis and properties of oligonucleotides containing 2’,4’-BNA/LNA-deazapurine analogues.
- Author(s)
  Hara Takashi, Kodama Tetsuya, Takegaki Yumi, Morihiro Kunihiko, Ito Kousuke R, Obika Satoshi
- Organizer
  10th Annual Meeting of the Oligonucleotide Therapeutics Society
- Place of Presentation
  San Diego, USA
- Year and Date
  2014-10-12 – 2014-10-14
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] 架橋型シクロヘキセニル核酸の機能性評価及び構造解析
- Author(s)
  百相義大、武田修一、松本友治、廣明秀一、小比賀聡、兒玉哲也
- Organizer
  第135回日本薬学会年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] ヌクレオシド・ヌクレオチドならびにオリゴヌクレオチドのメディシナルケミストリー
- Author(s)
  兒玉哲也
- Organizer
  中部地区医療・バイオ系シーズ発表会
- Place of Presentation
  愛知
- Data Source
  KAKENHI-PROJECT-24790110
[Presentation] 架橋型人工核酸（BNA）の核酸医薬への応用
- Author(s)
  兒玉哲也
- Organizer
  名古屋大学予防早期医療創成センター第４回ワークショップ
- Place of Presentation
  愛知
- Data Source
  KAKENHI-PROJECT-24790110
[Presentation] 架橋型シクロヘキセニル核酸の構造解析及び機能性評価
- Author(s)
  百相義大、武田修一、松本友治、廣明秀一、小比賀聡、兒玉哲也
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム2014
- Place of Presentation
  東京
- Year and Date
  2014-09-08 – 2014-09-09
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] 舟型ピラノース核酸類の合成とその標的結合能
- Author(s)
  森和土、兒玉哲也、小比賀聡
- Organizer
  第39回反応と合成の進歩シンポジウム
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24790110
[Presentation] チミン塩基をもつセレノメチレン架橋型人工核酸の合成と基本的性質
- Author(s)
  兒玉哲也，森廣邦彦，肯特夫，百相義大，VeeduR.N，小比賀聡
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム 2012
- Place of Presentation
  宮城県仙台市
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] 舟型ピラノース核酸類の合成とその標的結合能
- Author(s)
  森和土、兒玉哲也、小比賀聡
- Organizer
  第39回反応と合成の進歩シンポジウム
- Place of Presentation
  九州大学（福岡）
- Data Source
  KAKENHI-PROJECT-24249007
[Presentation] 架橋型シクロヘキセニル核酸の機能性評価及び構造解析
- Author(s)
  百相義大、武田修一、松本友治、廣明秀一、小比賀聡、兒玉哲也
- Organizer
  第135回日本薬学会年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460144
[Presentation] 核酸塩基の回転を制限したチミジン誘導体の合成研究
- Author(s)
  兒玉哲也、守屋彩子、廣明秀一
- Organizer
  第44回複素環化学討論会
- Place of Presentation
  札幌
- Year and Date
  2014-09-10 – 2014-09-12
- Data Source
  KAKENHI-PROJECT-26460144

1. OBIKA Satoshi (80243252)

# of Collaborated Projects: 3 results

# of Collaborated Products: 36 results
2. IMANISHI Takeshi (40028866)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. DOI Takefumi (00211409)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. HARI Yoshiyuki (50347423)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. YOSHIMITSU Takehiko (30301576)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KOJIMA Naoto (90420413)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TAKAGI Tatsuya (80144517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MORIHIRO Kunihiko (70713890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
9. KAWASHITA Norihito (00423111)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MAKINO Ai

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. HARA Takashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. KONDA Tatsuya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KODAMA Tetsuya 兒玉 哲也

兒玉 哲也 コダマ テツヤ

Research Projects

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Study on design of Artificial oligonucleotides based on structural control of sugar and phosphate moieties aiming at biostability and toxicity reductionPrincipal Investigator

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Scientific research on triplex-forming oligonucleotides aiming at to develop next-generation of medicinesPrincipal Investigator

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Development of platform technologies for antisense oligonucleotide-based therapeutics by a combination of nucleic acids chemistry and information sciences

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Study on artificial nucleic acids design based on the glycosidic bond angle controlPrincipal Investigator

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Development of synthetic methodology to supply materials for understanding of physiological system

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Study in chemical methylation of cytosine basePrincipal Investigator

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Development of oligonucleotide-based artificial transcription factor based on the higher-order structure of nucleic acids

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遺伝子発現の時空間制御を目的とした外部刺激応答性スイッチの開発

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Development of a Sequence-specific detection probe of damaged nucleobase for noninvasive DNA damage imaging.Principal Investigator

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Development of artificial nucleic acid conjugates as base materials for genome-based drug discovery and DNA-based diagnostics

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DNA配列特異的な8-ヒドロキシグアニンの認識;生きたDNA酸化損傷情報の視覚化Principal Investigator

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[Book] Therapeutic Oligonucleotides : Methods and Protocols2011

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[Book] Therapeutic Oligonucleotides : Methods and Protocols2011

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[Book] Therapeutic Oligonucleotides : Methods and Protocols2011

KODAMA Tetsuya 兒玉哲也

兒玉哲也コダマテツヤ