Shiroguchi Katsuyuki 城口克之

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SHIROGUCHI Katsuyuki 城口克之

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Researcher Number	00454059
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命機能科学研究センター, チームディレクター
Affiliation (based on the past Project Information) *help	2018 – 2024: 国立研究開発法人理化学研究所, 生命機能科学研究センター, チームリーダー 2018: 国立研究開発法人理化学研究所, 生命機能科学研究センター, ユニットリーダー 2016 – 2017: 国立研究開発法人理化学研究所, 生命システム研究センター, ユニットリーダー 2015: 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 上級研究員 2014: 独立行政法人理化学研究所, 統合生命医科学研究センター, 上級研究員 2007 – 2008: Waseda University, 理工学術院, 講師
Review Section/Research Field	Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Genome biology / Basic Section 43040:Biophysics-related / Genome biology / Complex systems / Molecular and Genome biology and related fields / Biological Sciences / Biophysics Except Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Basic Section 49060:Virology-related / Medium-sized Section 50:Oncology and related fields / Immunology / Animal production science
Keywords	Principal Investigator シークエンシング / 機械学習 / イメージング / １細胞解析 / 1細胞解析 / RNAシークエンシング / バイオイメージング / 遺伝子発現解析 / 細胞操作 / AI … More / Ｔ細胞 / シークエンサ / バーコード / 情報科学 / 網羅的計測 / 運命予測 / 細胞解析 / microscopy / cell-cell interaction / sequencing / T cell / TCR / 細胞相互作用 / ピッキング / 次世代シークエンサ / 遺伝子発現 / 自動化 / １細胞操作 / 免疫細胞 / 血液細胞 / 深層学習 / 一細胞解析 / 画像解析 / 細胞分取 / 網羅的遺伝子発現解析 / 免疫 / 受容体配列 / リンパ球 / 受容体 / 抗原 / 定量計測 / ネットワーク / 菌叢 / 腸内細菌 / 定量解析 / 細菌叢 / シークエンス / デジタル計測 / ゲノムワイド / バーコーディング / デジタル定量 / 高精度定量 / ハイスループット / 単一細胞解析 / 1分子生理学 / 角度計測 / 1分子計測 / エネルギー / アクチン / 運動 / Caged ATP / 一分子観察 / モーター蛋白質 / ミオシン / ATP / 構造変化 / 顕微鏡 / 分子モーター / 蛋白質 … More Except Principal Investigator 一細胞オミクス / 蛍光顕微鏡 / 1細胞オミクス / バイオイメージング / HIV / ウイルス感染症 / エイズウイルス / ウイルス感染 / マルチオミクス / システムウイルス学 / ウイルス学 / 固形腫瘍 / 免疫 / 腫瘍血管 / 代謝 / mitochondria / respiratory chain / interferon-gamma / mTORC1 / p62 / Nrf2 / がん細胞 / IFNg / 腫瘍浸潤CD8T細胞 / IFNγ / Glut-1 / NRF2 / CD8TIL / 活性酸素 / ミトコンドリア / 酸化的リン酸化 / 解糖系 / インターフェロンγ / CD8T細胞 / 腫瘍微小環境 / 免疫学 / 腸管免疫 / 腸管免疫系 / TCRレパトア解析 / シングルセル解析 / 大腸炎 / 繁殖 / 卵巣 / エクソソーム Less

多細胞システムの運命を左右する稀少細胞の検出とオミクス解析
- Principal Investigator
  
  市村垂生
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Osaka University
予測科学・網羅的解析の統合と細胞の未来決定機構の解明Principal Investigator
- Principal Investigator
  
  城口克之
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Institute of Physical and Chemical Research
The development of real-time transcriptome measurementPrincipal Investigator
- Principal Investigator
  
  城口克之
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Institute of Physical and Chemical Research
Development of highthrouput antigen determination methodPrincipal Investigator
- Principal Investigator
  
  Shiroguchi Katsuyuki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Institute of Physical and Chemical Research
Metabolism-based dissection of tumor microenvironment infiltrated by immune cells
- Principal Investigator
  
  UDONO Heiichiro
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Okayama University
Investigation of virus infection dynamics through comprehensive multi-omics approach
- Principal Investigator
  
  Sato Kei
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  The University of Tokyo
Single cell manipulation and gene expression analysis for "Singularity Biology"Principal Investigator
- Principal Investigator
  
  Shiroguchi Katsuyuki
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Institute of Physical and Chemical Research
Identification of microbiome network and "Master" bacteriaPrincipal Investigator
- Principal Investigator
  
  Shiroguchi Katsuyuki
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Molecular and Genome biology and related fields
- Research Institution
  Institute of Physical and Chemical Research
The study of the regulation of ovarian development and function by follicular exosome.
- Principal Investigator
  
  Sugiura Koji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Animal production science
- Research Institution
  The University of Tokyo
Development of a new high-throughput TCR-antigen pair identification method toward cancer immune therapyPrincipal Investigator
- Principal Investigator
  
  城口克之
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Genome biology
- Research Institution
  Institute of Physical and Chemical Research
Single cell analysis of T lymphocytes in the intestinal immune system
- Principal Investigator
  
  HASE Koji
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  Keio University
Development of genome-wide digital quantification method for non-coding RNAs which has single-base identification and single-molecule level quantificationPrincipal Investigator
- Principal Investigator
  
  SHIROGUCHI KATSUYUKI
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Genome biology
- Research Institution
  Institute of Physical and Chemical Research
細胞集団中のマイノリティのジェノタイプを一細胞レベルで同定する方法の開発Principal Investigator
- Principal Investigator
  
  城口克之
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Institute of Physical and Chemical Research
Standardization of genome-wide absolute and accurate counting of RNA moleculesPrincipal Investigator
- Principal Investigator
  
  SHIROGUCHI Katsuyuki
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Genome biology
- Research Institution
  The Institute of Physical and Chemical Research
Walking mechanism of myosin V : how 'ankle' action is regulatedPrincipal Investigator
- Principal Investigator
  
  SHIROGUCHI Katsuyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Waseda University

[Book] DNA分子バーコード法とその新機能バイオイノベーションに向けて　～バイテクノロジーの新技術からの新しい視点～2019
- Author(s)
  城口克之、小川泰策
- Total Pages
  255
- Publisher
  シーエムシー出版
- ISBN
  9784781314112
- Data Source
  KAKENHI-PLANNED-18H05411
[Book] 1細胞，1分子における核酸配列決定・定量技術の現状と展望2018
- Author(s)
  城口克之
- Total Pages
  108
- Publisher
  科学評論社
- Data Source
  KAKENHI-PLANNED-18H05411
[Book] JSI Newsletter2016
- Author(s)
  城口克之
- Total Pages
  1
- Publisher
  日本免疫学会
- Data Source
  KAKENHI-PROJECT-15K14425
[Book] ミオシンVは梃子 (てこ) の動作とブラウン運動により歩く2008
- Author(s)
  城口克之
- Total Pages
  17
- Publisher
  Japanese Scientists in Science
- Data Source
  KAKENHI-PROJECT-19579004
[Book] A rod probe reveals gait of myosin V Physics of Self-Organization Systems, edited by S. Ishiwata and Y. Matsunaga2008
- Author(s)
  K. Shiroguchi
- Publisher
  World Scientific
- Data Source
  KAKENHI-PROJECT-19579004
[Journal Article] High-throughput identification and quantification of single bacterial cells in the microbiota2022
- Author(s)
  Jin, J., Yamamoto, R., Takeuchi, T., Cui, G., Miyauchi, E., Hojo, N., Ikuta, K., Ohno, H., and Shiroguchi, K.
- Journal Title
  
  Nat. Commun.
  
  Volume: 13 Issue: 1 Pages: 863-863
- DOI
  10.1038/s41467-022-28426-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21525, KAKENHI-PLANNED-18H05411, KAKENHI-PROJECT-19H01030, KAKENHI-PROJECT-19K05907, KAKENHI-PROJECT-20H03501
[Journal Article] Robotic data acquisition with deep learning enables cell image-based prediction of transcriptomic phenotypes2022
- Author(s)
  Jin J., Ogawa T., Hojo N., Kryukov K., Shimizu K, Ikawa T., Imanishi T., Okazaki T., Shiroguchi K
- Journal Title
  
  Proc. Natl. Acad. Sci. USA.
  
  Volume: 120
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05411
[Journal Article] A circulating subset of iNKT cells mediates antitumor and antiviral immunity2022
- Author(s)
  Cui G,,, Shiroguchi K., Ikuta K.
- Journal Title
  
  Sci. Immunol.
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05411
[Journal Article] Different cell imaging methods did not significantly improve immune cell image classification performance2022
- Author(s)
  Ogawa T, Ochian K, Iwata T, Ikawa T, Tsuzuki T, Shiroguchi K and Takahashi K.
- Journal Title
  
  Plos One
  
  Volume: 17 Issue: 1 Pages: e0262397-e0262397
- DOI
  10.1371/journal.pone.0262397
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0222, KAKENHI-PLANNED-18H05411
[Journal Article] B cell-derived GABA elicits IL-10+ macrophages to?limit anti-tumour immunity2021
- Author(s)
  Zhang B,Vogelzang A,Miyajima M,Sugiura Y,Wu Y,Chamoto K,Nakano R,Hatae R,Menzies RJ,Sonomura K,Hojo N,Ogawa T,Kobayashi W,Tsutsui Y,Yamamoto S,Maruya M,Narushima S,Suzuki K,Sugiya H,Murakami K,Hashimoto M,Ueno H,Kobayashi T,Ito K,Hirano T,Shiroguchi K,Matsuda F,Suematsu M,Honjo T,Fagarasan S
- Journal Title
  
  Nature
  
  Volume: 599 Issue: 7885 Pages: 471-476
- DOI
  10.1038/s41586-021-04082-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14594, KAKENHI-PLANNED-18H05411, KAKENHI-PROJECT-21K19392
[Journal Article] Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes2021
- Author(s)
  Nishida Mikako、Yamashita Nahoko、Ogawa Taisaku、Koseki Keita、Warabi Eiji、Ohue Tomoyuki、Komatsu Masaaki、Matsushita Hirokazu、Kakimi Kazuhiro、Kawakami Eiryo、Shiroguchi Katsuyuki、Udono Heiichiro
- Journal Title
  
  Journal for ImmunoTherapy of Cancer
  
  Volume: 9 Issue: 9 Pages: e002954-e002954
- DOI
  10.1136/jitc-2021-002954
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05411, KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-18H04033, KAKENHI-PROJECT-21H04771, KAKENHI-PROJECT-19H03528, KAKENHI-PROJECT-21K15505, KAKENHI-PROJECT-16H06276
[Journal Article] HaloTag-based conjugation of proteins to barcoding-oligonucleotides2020
- Author(s)
  3.Yazaki J*, Kawashima Y, Ogawa T, Kobayashi A, Okoshi M, Watanabe T, Yoshida S, Kii I, Egami S, Amagai M, Hosoya T, Shiroguchi K, Ohara O
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 48 Issue: 2 Pages: e8-e8
- DOI
  10.1093/nar/gkz1086
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05411, KAKENHI-PROJECT-19K05745, KAKENHI-PROJECT-19H02856
[Journal Article] Osteoprotegerin-dependent Mcell self-regulation balances gut infection and immunity.2020
- Author(s)
  Kimura S, Nakamura Y, Kobayashi N, Shiroguchi K, KawakamiE, Mutoh M, Takahashi-Iwanaga H, Yamada T, Hisamoto M, Nakamura M, Udagawa N, Sato S, KaishoT, Iwanaga T, Hase K.
- Journal Title
  
  Nat Commun
  
  Volume: 11 Issue: 1 Pages: 234-234
- DOI
  10.1038/s41467-019-13883-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08504, KAKENHI-PROJECT-19K07239, KAKENHI-PROJECT-19K10395, KAKENHI-PROJECT-19K22532, KAKENHI-PROJECT-19K21170, KAKENHI-PUBLICLY-18H04680, KAKENHI-PLANNED-18H05411, KAKENHI-PUBLICLY-19H04813, KAKENHI-PROJECT-17H04088, KAKENHI-PROJECT-17H04089, KAKENHI-PROJECT-19H03702, KAKENHI-PROJECT-17KT0055, KAKENHI-PROJECT-17K19776, KAKENHI-PROJECT-20K21689
[Journal Article] Multiomics Investigation Revealing the Characteristics of HIV-1-Infected Cells In?Vivo2020
- Author(s)
  Aso Hirofumi、Nagaoka Shumpei、Kawakami Eiryo、Ito Jumpei、Islam Saiful、Tan Benjy Jek Yang、Nakaoka Shinji、Ashizaki Koichi、Shiroguchi Katsuyuki、Suzuki Yutaka、Satou Yorifumi、Koyanagi Yoshio、Sato Kei
- Journal Title
  
  Cell Reports
  
  Volume: 32 Issue: 2 Pages: 107887-107887
- DOI
  10.1016/j.celrep.2020.107887
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15767, KAKENHI-PROJECT-18KK0447, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-PLANNED-18H05411, KAKENHI-PUBLICLY-19H04826, KAKENHI-PROJECT-18H02662, KAKENHI-PROJECT-20H03724, KAKENHI-PROJECT-19J01713, KAKENHI-PROJECT-19J22802, KAKENHI-PROJECT-20J23299, KAKENHI-PROJECT-18KK0230, KAKENHI-PROJECT-16H06279, KAKENHI-ORGANIZER-16H06429
[Journal Article] Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation2019
- Author(s)
  Miyamoto Chizuko、Kojo Satoshi、Yamashita Motoi、Moro Kazuyo、Lacaud Georges、Shiroguchi Katsuyuki、Taniuchi Ichiro、Ebihara Takashi
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 447-447
- DOI
  10.1038/s41467-019-08365-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05805, KAKENHI-PROJECT-18H02647, KAKENHI-PUBLICLY-19H04820, KAKENHI-PLANNED-19H05747, KAKENHI-PROJECT-17H04090, KAKENHI-PLANNED-18H05411, KAKENHI-PROJECT-18H02620
[Journal Article] 次世代シークエンサーを用いたDNA, RNAの網羅的デジタル計測2016
- Author(s)
  城口克之
- Journal Title
  
  現代化学
  
  Volume: 546 Pages: 47-50
- Data Source
  KAKENHI-PROJECT-15K14425
[Journal Article] デジタルRNAシークエンシング：ゲノムワイドな１分子定量法2016
- Author(s)
  城口克之
- Journal Title
  
  生物と化学
  
  Volume: 印刷中
- NAID
  130006176426
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-26115719
[Journal Article] デジタルRNAシークエンシング　ゲノムワイドな１分子定量法2016
- Author(s)
  城口克之
- Journal Title
  
  生物と化学（日本農芸化学会）
  
  Volume: 54 Pages: 787-788
- NAID
  130006176426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K14425
[Journal Article] 2本足モーター, ミオシンVの脚の動きを見る2009
- Author(s)
  城口克之
- Journal Title
  
  生物物理 49
  
  Pages: 27-29
- NAID
  110007044733
- Data Source
  KAKENHI-PROJECT-19579004
[Journal Article] 2本足モーター、ミオシンVの脚の動きを見る2009
- Author(s)
  城口克之
- Journal Title
  
  生物物理 49(1)
  
  Pages: 27-29
- NAID
  110007044733
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19579004
[Journal Article] ミオシンVは梃子(てこ)の動作とブラウン運動により歩く2008
- Author(s)
  城口克之
- Journal Title
  
  Japanese Scientists in Science
  
  Pages: 17-17
- Data Source
  KAKENHI-PROJECT-19579004
[Journal Article] Myosin V walks by lever action and Brownian motion2007
- Author(s)
  Katsuyuki Shiroguchi and Kazuhiko Kinosita, Jr.
- Journal Title
  
  Science 316
  
  Pages: 1208-1212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19579004
[Patent] 核酸増幅に関する技術（仮）2022
- Inventor(s)
  城口克之、他
- Industrial Property Rights Holder
  理化学研究所、他
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-004729
- Filing Date
  2022
- Data Source
  KAKENHI-PLANNED-18H05411
[Patent] 細胞操作に関する技術（仮）2020
- Inventor(s)
  城口克之、他
- Industrial Property Rights Holder
  理化学研究所、他
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PLANNED-18H05411
[Patent] 細胞搬送システム2018
- Inventor(s)
  城口克之、他
- Industrial Property Rights Holder
  理化学研究所、他
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Acquisition Date
  2022
- Data Source
  KAKENHI-PLANNED-18H05411
[Patent] 細胞搬送システム2018
- Inventor(s)
  城口克之、小川泰策、平藤衛
- Industrial Property Rights Holder
  理化学研究所、ヨダカ技研（株）
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-203728
- Filing Date
  2018
- Data Source
  KAKENHI-PLANNED-18H05411
[Patent] 光学顕微鏡の長焦点深度観察方法と光学顕微鏡2008
- Inventor(s)
  城口克之, 木下一彦
- Industrial Property Rights Holder
  早稲田大学, メイジテクノ株式会社
- Industrial Property Number
  2008-023166
- Filing Date
  2008-02-01
- Data Source
  KAKENHI-PROJECT-19579004
[Presentation] 細胞死の不可逆性の理解に向けた、一細胞遺伝子発現解析と細胞の運命予測の統合2023
- Author(s)
  岡庭有明、城口克之
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K18118
[Presentation] 細胞死の不可逆性の理解に向けた、一細胞遺伝子発現解析と機械学習による細胞の運命予測の統合2023
- Author(s)
  岡庭有明、城口克之
- Organizer
  第61回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-23K18118
[Presentation] Developing live-image based transcriptomic state prediction for studying dynamics of the metastasis model EMT2023
- Author(s)
  Tobias Frick、城口克之
- Organizer
  第４６回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K23855
[Presentation] Predicting cell fates by image-based machine learning for comprehensive and quantitative understanding of cell death and survival2022
- Author(s)
  Tomoaki Okaniwa, Katsuyuki Shiroguchi
- Organizer
  第60回日本生物物理学会年会
- Data Source
  KAKENHI-PLANNED-18H05411
[Presentation] Live prediction with image-based deep learning accesses temporal variability of single-cell transcriptomic states2022
- Author(s)
  Tobias Frick, Katsuyuki Shiroguchi
- Organizer
  日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-23K23855
[Presentation] バイオDXの効果？　細胞の”顔つき”から種類・状態を捉える2022
- Author(s)
  城口克之
- Organizer
  第433回CBI学会講演会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05411
[Presentation] 実験自動化ロボットの開発と統合データ解析による１細胞decoding2021
- Author(s)
  城口克之
- Organizer
  バイオＤＸの最前線　CRESTバイオＤＸキックオフシンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-18H05411
[Presentation] An automated microscopy-based picking system for single cells which links dynamic behavior with whole gene expression2021
- Author(s)
  Katsuyuki Shiroguchi
- Organizer
  Pacifichem2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05411
[Presentation] バイオイメージングとRNAシークエンシング（と機械学習）の融合による１細胞動態解析2020
- Author(s)
  城口克之
- Organizer
  九州大学先導物質化学研究所　非常勤講師セミナー
- Invited
- Data Source
  KAKENHI-PLANNED-18H05411
[Presentation] 細胞動態観察・オミックス解析・機械学習を融合した新規 1 細胞解析法の開発と免疫研究への応用2020
- Author(s)
  城口克之
- Organizer
  東京理科大学　総合研究院合成生物学研究部門シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-18H05411
[Presentation] １細胞統合解析：　ライブイメージングと網羅的遺伝子発現解析の融合2020
- Author(s)
  城口克之
- Organizer
  広島県立大学　生命システム科学特別講義
- Invited
- Data Source
  KAKENHI-PLANNED-18H05411
[Presentation] １細胞を観て採る自動システム2020
- Author(s)
  城口克之
- Organizer
  Laboratory Automation Developers Conference 2020
- Invited
- Data Source
  KAKENHI-PLANNED-18H05411
[Presentation] Development of an automated system to take datasets of images and sequences for the same single cells2020
- Author(s)
  Taisaku Ogawa, Katsuyuki Shiroguchi
- Organizer
  AGBT2020
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05411
[Presentation] Linking cell dynamics and gene expression by integration of live imaging and RNA sequencing2019
- Author(s)
  城口　克之
- Organizer
  LSBM　Symposium 2019
- Invited
- Data Source
  KAKENHI-PLANNED-18H05411
[Presentation] 細胞動態と遺伝子発現状態を繋ぐ：顕微鏡ライブイメージングと１細胞RNAシークエンシングの融合と自動化2019
- Author(s)
  城口　克之
- Organizer
  第57回日本生物物理学会年会バイオフィジックスセミナー
- Invited
- Data Source
  KAKENHI-PLANNED-18H05411
[Presentation] Probing Taxa-Specific Bacterial Coordinational Distribution in Intestinal Microbiota by Super-accurate Method BarBIQ2019
- Author(s)
  J. Jin, R. Yamamoto, T. Takeuchi, E. Miyauchi, H. Ohno, K. Shiroguchi
- Organizer
  EMBL Symposia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17F17389
[Presentation] Automation of live imaging, single cell picking, and sequencing system2019
- Author(s)
  Katsuyuki Shiroguchi
- Organizer
  ICSB2019
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05411
[Presentation] 顕微鏡ライブイメージングと1細胞RNA-seqを組み合わせた自動化システムの開発とシンギュラリティ生物学への応用2019
- Author(s)
  小川　泰策、城口　克之
- Organizer
  第57回日本生物物理学会年会
- Data Source
  KAKENHI-PLANNED-18H05411
[Presentation] 新規手法開発により生命システムの理解へ迫る：①核酸・細胞の“デジタル”定量法の開発 ②シークエンシングとライブイメージング法の融合2019
- Author(s)
  城口　克之
- Organizer
  京都大学ウイルス・再生医科学研究所　セミナー
- Invited
- Data Source
  KAKENHI-PLANNED-18H05411
[Presentation] 細胞動態と遺伝子発現を結ぶイメージングとシークエンシングの統合解析2019
- Author(s)
  城口　克之
- Organizer
  第19回日本蛋白質科学会年会・第71回日本細胞生物学会大会
- Data Source
  KAKENHI-PLANNED-18H05411
[Presentation] 細胞の網羅的遺伝子発現の経時”計測”と未来予測に向けて2018
- Author(s)
  城口　克之
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-18H05411
[Presentation] An applicational study of a novel developed method BarBIQ: analysis of microbiota in different locations of a murine cecum & colon2018
- Author(s)
  Janshi Jin, Reiko Yamamoto, Tadashi Takeuchi, Eiji Miyauchi, Hiroshi Ohno, Katsuyuki Shiroguchi
- Organizer
  The 47th Annual Meeting of The Japanese society of Immunology
- Data Source
  KAKENHI-PROJECT-17F17389
[Presentation] A novel quantification method for bacterial microbiota analysis with high dynamic range cell barcording2018
- Author(s)
  Katsuyuki Shiroguchi
- Organizer
  IFPT’10＆IWSC'11
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19364
[Presentation] A novel method for the high throughout analysis of bacterial microbiota: bacteria identification with the single-base accuracy and bacteria quantification at the single-cell level2018
- Author(s)
  Katsuyuki Shiroguchi
- Organizer
  BIT's 8th Annual Congress of Molecular & Cell Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19364
[Presentation] An automated system of single cell picking and sequencing for dynamic observation of living cells2018
- Author(s)
  城口　克之
- Organizer
  日本生物物理学会第56回年会
- Data Source
  KAKENHI-PLANNED-18H05411
[Presentation] A novel high-throughput method for quantification of microbiota distribution at the single cell level using high dynamic range DNA barcofing2018
- Author(s)
  Katsuyuki Shiroguchi, Janshi Jin,Tadashi Takeuchi,Eiji Miyauchi, Hiroshi Ohno
- Organizer
  IMMUNOLOGY　(USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19364
[Presentation] A robotic system for combining single-cell RNA-seq with live cell imaging2018
- Author(s)
  小川　泰策, 伊川　友活, 城口　克之
- Organizer
  日本生物物理学会第56回年会
- Data Source
  KAKENHI-PLANNED-18H05411
[Presentation] 次世代細菌叢解析:高いダイナミックレンジをもつDNAバーコードを用いて2017
- Author(s)
  城口克之
- Organizer
  2017年度生命科学系学会合同年次大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K19364
[Presentation] １細胞レベル・塩基分解能でのハイスープット菌叢解析2017
- Author(s)
  城口克之、Jianshi Jin
- Organizer
  第11回日本ゲノム微生物学会年会
- Place of Presentation
  慶應義塾大学（神奈川県、藤沢市）
- Year and Date
  2017-03-02
- Data Source
  KAKENHI-PROJECT-15K14425
[Presentation] A novel high-throughput method for quantification of microbiota distribution at the single cell level2017
- Author(s)
  Jianshi Jin, Tadashi Takeuchi, Eiji Miyauchi, Hiroshi Ohno, Katsuyuki Shiroguchi
- Organizer
  CSH Asia on “Tumor Immunology & Immunotherapy”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17F17389
[Presentation] DNA分子バーコード法の新機能と新規細菌叢解析への展開2017
- Author(s)
  城口克之
- Organizer
  AMED成果報告会学東海大学医学部生命科学
- Invited
- Data Source
  KAKENHI-PROJECT-17K19364
[Presentation] A novel high-throughput method for bacteria counting and de-novo 16S rRNA sequence identification with single-base resolution2017
- Author(s)
  Jianshi Jin1, Kaori Fukuhara, Tadashi Takeuchi, Eiji Miyauchi, Hiroshi Ohno, Katsuyuki Shiroguchi
- Organizer
  The 46th Annual Meeting of The Japanese society of Immunology
- Data Source
  KAKENHI-PROJECT-17F17389
[Presentation] Finding genomic minority cells by sequencing2016
- Author(s)
  城口克之
- Organizer
  第54回日本生物物理学会年会
- Place of Presentation
  つくば国際会議場（茨城県、つくば市）
- Year and Date
  2016-11-25
- Invited
- Data Source
  KAKENHI-PROJECT-15K14425
[Presentation] High Throughput Single Cell Analysis for Target Genomic Sequences2016
- Author(s)
  城口克之
- Organizer
  International conference on Single Cell Research 2016
- Place of Presentation
  東京大学（東京都、文京区）
- Year and Date
  2016-11-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14425
[Presentation] A Novel Method for High Throughput Single Cell Identification and Counting by Target Gene Sequencing2016
- Author(s)
  城口克之
- Organizer
  QBiC Symposium 2016
- Place of Presentation
  千里ライフサイエンスセンター（大阪府、豊中市）
- Year and Date
  2016-09-06
- Invited
- Data Source
  KAKENHI-PROJECT-15K14425
[Presentation] 細胞集団中のマイノリティのジェノタイプを一細胞レベルで同定する方法の開発2015
- Author(s)
  城口克之
- Organizer
  日本生物物理学会年会
- Place of Presentation
  金沢大学（石川県金沢市）
- Year and Date
  2015-09-14
- Invited
- Data Source
  KAKENHI-PUBLICLY-26115719
[Presentation] Genome-wide Digital mRNA Counting Using "Molecular Barcoding" and Its Application for Differentiation Study2015
- Author(s)
  Katsuyuki Shiroguchi
- Organizer
  BIT’s 5th Annual World Congress of Molecular & Cell Biology-2015
- Place of Presentation
  Nanjing, China
- Year and Date
  2015-04-26
- Invited
- Data Source
  KAKENHI-PROJECT-26640119
[Presentation] Genome-wide Digital mRNA Counting Using "Molecular Barcoding" and Its Application for Differentiation Study2015
- Author(s)
  Katsuyuki Shiroguchi
- Organizer
  BIT’s 5th Annual World Congress of Molecular & Cell Biology -2015
- Place of Presentation
  Nangjing (China)
- Year and Date
  2015-04-26
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14425
[Presentation] RNA分子数の絶対定量により状態変化を捉える：分子バーコーディング法によるRNAゲノムワイドデジタル計測法の開発とその応用2014
- Author(s)
  城口克之
- Organizer
  日本細胞生物学会
- Place of Presentation
  奈良県新公会堂（奈良県・奈良市）
- Year and Date
  2014-06-11
- Data Source
  KAKENHI-PROJECT-26640119
[Presentation] Towards next generation system-wide measurements: Highly accurate and absolute quantification of RNA molecules from small amounts of sample by "molecular barcoding"2014
- Author(s)
  城口克之
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-11-26
- Invited
- Data Source
  KAKENHI-PROJECT-26640119
[Presentation] Accurate system-wide gene expression analysis with single molecule resolution by using molecular barcoding2014
- Author(s)
  Katsuyuki Shiroguchi
- Organizer
  MicroRNAs & Single Molecule Biology/Genome Editing Europe Symposia-2014
- Place of Presentation
  Cambridge, UK
- Year and Date
  2014-11-03
- Invited
- Data Source
  KAKENHI-PROJECT-26640119
[Presentation] Absolute genome-wide quantification of gene expression with single molecule resolution using molecular barcoding2014
- Author(s)
  城口克之
- Organizer
  日本生物物理学会
- Place of Presentation
  札幌コンベンションセンター（北海道・札幌市）
- Year and Date
  2014-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-26640119
[Presentation] 100 cell transcriptome analysis: highly accurate absolute digital quantification with single molecule resolution using molecular barcoding2014
- Author(s)
  城口克之
- Organizer
  日本免疫学会
- Place of Presentation
  国立京都国際会館（京都府・京都市）
- Year and Date
  2014-12-12
- Data Source
  KAKENHI-PROJECT-26640119
[Presentation] Watching 'anckle' action of myosin V2009
- Author(s)
  K. Shiroguchi, H. F. Chin, E. Muneyuki, E. M. De La Cruz, K. Kinosita Jr.
- Organizer
  53^<th> Annual Meeting of the Biophysical Society of U.S.A
- Place of Presentation
  Boston Massachusetts U.S.A.
- Data Source
  KAKENHI-PROJECT-19579004
[Presentation] ミオシンVのリカバリーストロークの顕微鏡観察 : 一方向性運動における役割2009
- Author(s)
  城口克之
- Place of Presentation
  東京大学
- Data Source
  KAKENHI-PROJECT-19579004
[Presentation] ミオシンVのリカバリーストロークの顕微鏡観察 : 一方向性運動における役割2009
- Author(s)
  城口克之
- Organizer
  生体運動合同班会議
- Place of Presentation
  東京大学(駒場)
- Year and Date
  2009-01-10
- Data Source
  KAKENHI-PROJECT-19579004
[Presentation] ミオシンVの足首の動きを見る (アクチンなし)2008
- Author(s)
  城口克之, Harvey Chin, 宗行英朗, Enrique M. De La Cruz, 木下一彦
- Organizer
  日本生物物理学会第46回年会
- Place of Presentation
  福岡国際会議場、福岡
- Data Source
  KAKENHI-PROJECT-19579004
[Presentation] 「一分子による構造変化の研究 : ミオシンVの歩き方」大阪大学蛋白質研究所セミナー '蛋白質の構造変化の仕組みを探る'2008
- Author(s)
  城口克之
- Organizer
  大阪大学蛋白質研究所
- Year and Date
  2008-03-03
- Data Source
  KAKENHI-PROJECT-19579004
[Presentation] ミオシンVの足首の動きを見る(アクチンなし)2008
- Author(s)
  城口克之
- Organizer
  第46回日本生物物理学会年会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2008-12-04
- Data Source
  KAKENHI-PROJECT-19579004
[Presentation] ミオシンVの歩く仕組み2007
- Author(s)
  城口克之
- Organizer
  日本生物物理学会
- Place of Presentation
  横浜
- Year and Date
  2007-12-23
- Data Source
  KAKENHI-PROJECT-19579004
[Presentation] 「二本 '足' を持つ輸送モーター、ミオシンVの歩き方」「アクチン・ミオシン : 分子と細胞を如何にして結び付けるか」の会2007
- Author(s)
  城口克之
- Organizer
  ワークショップ
- Place of Presentation
  早稲田大学
- Year and Date
  2007-11-10
- Data Source
  KAKENHI-PROJECT-19579004
[Presentation] 'Walking' mechanisms of myosin V, a two-'foot' linear motor protein2007
- Author(s)
  Katsuyuki Shiroguchi
- Organizer
  The 5th 21st century COE symposium on Physics of Self-organization Systems「Toward Next Generation Physics」
- Place of Presentation
  Ibuka Hall International Conference Center Waseda University, Tokyo
- Data Source
  KAKENHI-PROJECT-19579004
[Presentation] ミオシンVの歩く仕組みと, 生体 'モーター' の理解へ向けて2007
- Author(s)
  城口克之
- Organizer
  日本生物物理学会第45回年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19579004
[Presentation] Highly Reproducible and Sensitive Genome-Wide Digital RNA Counting using Molecular Barcoding
- Author(s)
  Katsuyuki Shiroguchi
- Organizer
  Gordon Research Conference
- Place of Presentation
  South Hadley, USA
- Year and Date
  2014-08-03 – 2014-08-07
- Data Source
  KAKENHI-PROJECT-26640119

1. Sugiura Koji (20595623)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. HASE Koji (20359714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. UDONO Heiichiro (50260659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Sato Kei (10593684)

# of Collaborated Projects: 1 results

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5. 藤井渉 (40708161)

# of Collaborated Projects: 1 results

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6. 菱木貴子 (10338022)

# of Collaborated Projects: 1 results

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7. 久保亜紀子 (50455573)

# of Collaborated Projects: 1 results

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8. 中岡慎治 (30512040)

# of Collaborated Projects: 1 results

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9. 鈴木穣 (40323646)

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10. 市村垂生 (50600748)

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11. JIN JIANSHI

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
12. IKAWA Tomokatsu

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# of Collaborated Products: 1 results
13. 生田宏一

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14. 崔广為

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15. 中野令

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16. 岩永ひろみ

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17. 伊東潤平

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18. 谷内一郎

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Shiroguchi Katsuyuki 城口 克之

SHIROGUCHI Katsuyuki 城口 克之

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多細胞システムの運命を左右する稀少細胞の検出とオミクス解析

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予測科学・網羅的解析の統合と細胞の未来決定機構の解明Principal Investigator

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The development of real-time transcriptome measurementPrincipal Investigator

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Development of highthrouput antigen determination methodPrincipal Investigator

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Metabolism-based dissection of tumor microenvironment infiltrated by immune cells

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Investigation of virus infection dynamics through comprehensive multi-omics approach

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Single cell manipulation and gene expression analysis for "Singularity Biology"Principal Investigator

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Identification of microbiome network and "Master" bacteriaPrincipal Investigator

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The study of the regulation of ovarian development and function by follicular exosome.

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Development of a new high-throughput TCR-antigen pair identification method toward cancer immune therapyPrincipal Investigator

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Single cell analysis of T lymphocytes in the intestinal immune system

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Development of genome-wide digital quantification method for non-coding RNAs which has single-base identification and single-molecule level quantificationPrincipal Investigator

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細胞集団中のマイノリティのジェノタイプを一細胞レベルで同定する方法の開発Principal Investigator

Principal Investigator

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Shiroguchi Katsuyuki 城口克之

SHIROGUCHI Katsuyuki 城口克之

[Book] DNA分子バーコード法とその新機能バイオイノベーションに向けて　～バイテクノロジーの新技術からの新しい視点～2019