Shuichi Mori 森修一

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MORI Shuichi 森修一

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Researcher Number	00467630
Affiliation (based on the past Project Information) *help	2018 – 2022: 東京医科歯科大学, 生体材料工学研究所, 助教 2012: 東京医科歯科大学, 生体材料工学研究所, 助教 2012: 東京医科歯科大学, 生体材料工学研究所, 特任助教 2011: 東京医科歯科大学, 大学院疾患生命科学研究部, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Drug development chemistry Except Principal Investigator Basic Section 47040:Pharmacology-related
Keywords	Principal Investigator フッ素 / 6配位フッ化硫黄化合物 / 六配位フッ化硫黄構造 / レチノイド / テトラフルオロスルファニル基 / ペンタフルオロスルファニル基 / 核内受容体 / 医薬化学 / ヒストンメチル化 / 蛍光プローブ / SNAr反応 / ヒストンメチル化酵素 / エピジェネティクス … More Except Principal Investigator … More 筋小胞体 / 大規模スクリーニング / 細胞内カルシウム動態 / モデルマウス / カテコラミン誘発性多型性心室頻拍 / RyR2阻害薬 / ハイスループットスクリーニング / 抗不整脈薬 / 2型リアノジン受容体 / ドラッグスクリーニング / カルシウム / 心臓 / 不整脈 / リアノジン受容体 Less

Effectiveness of RyR2 inhibitors as antiarrhytmic drugs
- Principal Investigator
  
  Kurebayashi Nagomi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Juntendo University
Development of novel structural elements bearing hexa-coordinated sulfur fluorides and application to nuclear receptor-ligandsPrincipal Investigator
- Principal Investigator
  
  Shuichi Mori
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Tokyo Medical and Dental University
Development of the method for screening histone methyl transferase inhibitors utilizing the novel fluorescent probe.Principal Investigator
- Principal Investigator
  
  MORI Shuichi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo Medical and Dental University

All 2022 2021 2020 2019 2018 2013 2011

All Journal Article Presentation Patent

[Journal Article] NRSF- GNAO1 Pathway Contributes to the Regulation of Cardiac Ca 2+ Homeostasis2022
- Author(s)
  Inazumi Hideaki、Kuwahara Koichiro、Nakagawa Yasuaki、et al.
- Journal Title
  
  Circulation Research
  
  Volume: 130 Issue: 2 Pages: 234-248
- DOI
  10.1161/circresaha.121.318898
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07297, KAKENHI-PROJECT-19K08580, KAKENHI-PROJECT-19K16497, KAKENHI-PROJECT-20H03673, KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-19K07116, KAKENHI-PROJECT-19K07299, KAKENHI-PROJECT-21K08126, KAKENHI-PROJECT-20K17077, KAKENHI-PROJECT-22K08099
[Journal Article] Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca2+ dynamics in primary skeletal myocytes2022
- Author(s)
  Tsuboi Yoshitaka、Oyama Kotaro、Kobirumaki-Shimozawa Fuyu、Murayama Takashi、Kurebayashi Nagomi、Tachibana Toshiaki、Manome Yoshinobu、Kikuchi Emi、Noguchi Satoru、Inoue Takayoshi、Inoue Yukiko U.、Nishino Ichizo、Mori Shuichi、Ishida Ryosuke、Kagechika Hiroyuki、Suzuki Madoka、Fukuda Norio、Yamazawa Toshiko
- Journal Title
  
  Journal of General Physiology
  
  Volume: 154 Issue: 11
- DOI
  10.1085/jgp.202213136
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06789, KAKENHI-PROJECT-22K06652, KAKENHI-PROJECT-21K19929, KAKENHI-PLANNED-22H05053, KAKENHI-PLANNED-22H05054, KAKENHI-PLANNED-22H05055, KAKENHI-PROJECT-20H03421, KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-19K07306, KAKENHI-PROJECT-20K06467, KAKENHI-PROJECT-19H03404, KAKENHI-PROJECT-23K24778, KAKENHI-PROJECT-23K24067
[Journal Article] Development of a water-soluble ryanodine receptor 1 inhibitor2022
- Author(s)
  Ishida Ryosuke、Mori Shuichi、Murayama Takashi、Nakamichi Ayaka、Chai Xikun、Kurebayashi Nagomi、Iinuma Hiroto、Kagechika Hiroyuki
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 74 Pages: 117027-117027
- DOI
  10.1016/j.bmc.2022.117027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06652, KAKENHI-PROJECT-22K15244, KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-19H03404, KAKENHI-PROJECT-23K24067
[Journal Article] A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery2022
- Author(s)
  Murayama Takashi、Kurebayashi Nagomi、Numaga-Tomita Takuro、Kobayashi Takuya、Okazaki Satoru、Yamashiro Kyosuke、Nakada Tsutomu、Mori Shuichi、Ishida Ryosuke、Kagechika Hiroyuki、Yamada Mitsuhiko、Sakurai Takashi
- Journal Title
  
  Journal of General Physiology
  
  Volume: 154 Issue: 12
- DOI
  10.1085/jgp.202213230
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06652, KAKENHI-PROJECT-22K06828, KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-19H03404, KAKENHI-PROJECT-23K24067
[Journal Article] A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke2021
- Author(s)
  Yamazawa Toshiko、Kobayashi Takuya、Kurebayashi Nagomi、Konishi Masato、Noguchi Satoru、Inoue Takayoshi、Inoue Yukiko U.、et al.
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 4293-4293
- DOI
  10.1038/s41467-021-24644-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H04922, KAKENHI-PROJECT-19H03198, KAKENHI-PROJECT-19K06955, KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-19K07306, KAKENHI-PROJECT-20K06467, KAKENHI-PROJECT-20K11368, KAKENHI-PROJECT-21K19752, KAKENHI-PROJECT-19H03404
[Journal Article] Differential effects of the formin inhibitor SMIFH2 on contractility and Ca 2+ handling in frog and mouse cardiomyocytes2021
- Author(s)
  Sakata Koji、Matsuyama Sho、Kurebayashi Nagomi、Hayamizu Kengo、Murayama Takashi、Nakamura Kunihide、Kitamura Kazuo、Morimoto Sachio、Takeya Ryu
- Journal Title
  
  Genes to Cells
  
  Volume: 26 Issue: 8 Pages: 583-595
- DOI
  10.1111/gtc.12873
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07297, KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-19K07355, KAKENHI-PROJECT-19H03404
[Journal Article] Structural development of a type-1 ryanodine receptor (RyR1) Ca2+-release channel inhibitor guided by endoplasmic reticulum Ca2+ assay2019
- Author(s)
  Mori Shuichi、Iinuma Hiroto、Manaka Noriaki、Ishigami-Yuasa Mari、Murayama Takashi、Nishijima Yoshiaki、Sakurai Akiko、Arai Ryota、Kurebayashi Nagomi、Sakurai Takashi、Kagechika Hiroyuki
- Journal Title
  
  European Journal of Medicinal Chemistry
  
  Volume: 179 Pages: 837-848
- DOI
  10.1016/j.ejmech.2019.06.076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-16H04667, KAKENHI-PROJECT-16K08507, KAKENHI-PROJECT-19H03404
[Patent] ２型リアノジン受容体活性抑制剤2022
- Inventor(s)
  國廣なごみ、村山尚、影近弘之、森修一、湯浅磨里、飯沼大翔
- Industrial Property Rights Holder
  順天堂大学、東京医科歯科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-19K07105
[Patent] ２型リアノジン受容体活性抑制剤2021
- Inventor(s)
  国広なごみ、村山尚、影近弘之、森修一、湯浅磨里、飯沼大翔
- Industrial Property Rights Holder
  国広なごみ、村山尚、影近弘之、森修一、湯浅磨里、飯沼大翔
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-19K07105
[Patent] ２型リアノジン受容体活性抑制剤2020
- Inventor(s)
  国広なごみ、村山尚、影近弘之、森修一、湯浅磨里、飯沼大翔
- Industrial Property Rights Holder
  順天堂大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-020656
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K07105
[Presentation] CPVTモデルマウスに対するRyR2特異的阻害薬の効果2021
- Author(s)
  呉林なごみ, 村山尚, 石井光一郎, 小西真人, 杉原匡美, 森修一, 飯沼大翔, 湯浅磨里, 村越伸行, 影近弘之, 櫻井隆
- Organizer
  第94回　日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07105
[Presentation] Effects of novel RyR2 inhibitors on cardiac myocytes from diseased hearts2020
- Author(s)
  Nagomi Kurebayashi, Takashi Murayama, Masato Konishi, Shuichi Mori, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Haruo Ogawa, Sachio Morimoto, Takashi Sakurai
- Organizer
  63th Annual Meeting of the Biophysical Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07105
[Presentation] trans-テトラフルオロスルファニル構造を有する新規レチノイドの創製2019
- Author(s)
  杖本望、森修一、河内恵美子、影近弘之
- Organizer
  日本レチノイド研究会第30回学術集会
- Data Source
  KAKENHI-PROJECT-18K06546
[Presentation] 六配位フッ化硫黄構造を有するレチノイドの創製2019
- Author(s)
  杖本望、森修一、河内恵美子、影近弘之
- Organizer
  日本薬学会第139年回
- Data Source
  KAKENHI-PROJECT-18K06546
[Presentation] ペンタフルオロスルファニル基を脂溶性部位として有する新規レチノイドの創製2019
- Author(s)
  森修一、杖本望、河内恵美子、影近弘之
- Organizer
  日本ビタミン学会第71回大会
- Data Source
  KAKENHI-PROJECT-18K06546
[Presentation] 六配位フッ化硫黄構造を有する新規レチノイドの創製2019
- Author(s)
  森修一、杖本望、河内恵美子、影近弘之
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-18K06546
[Presentation] 六配位フッ化硫黄構造を有する核内受容体リガンドの創製2018
- Author(s)
  森修一、杖本望、河内恵美子、影近弘之
- Organizer
  日本レチノイド研究会第29回学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06546
[Presentation] ペンタフルオロスルファニル基を疎水性部位に有する新規レチノイドの創製2018
- Author(s)
  杖本望、森修一、河内恵美子、影近弘之
- Organizer
  日本ケミカルバイオロジー学会第13回年回
- Data Source
  KAKENHI-PROJECT-18K06546
[Presentation] Discrimination between lysine and N--methyllysine using SNAr reactions2013
- Author(s)
  Shuichi Mori, Takashi Fujiwara, Asuka Takaguchi, Tomoya Hirano, Hiroyuki Kagechika
- Organizer
  The 2nd HD Physiology International Symposium
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790127
[Presentation] Discrimination between lysine and N-〓-methyllysine using SNAr reactions2013
- Author(s)
  Shuichi Mori
- Organizer
  The 2nd HD Physiology International Symposium
- Place of Presentation
  Tokyo
- Year and Date
  2013-06-29
- Data Source
  KAKENHI-PROJECT-23790127
[Presentation] SNAr反応を利用したリジン・メチル化リジンの識別2013
- Author(s)
  高口明日香、森修一、平野智也、影近弘之
- Organizer
  日本薬学会　第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790127
[Presentation] Development of Novel Bisubstrate-Type Inhibitor of Histone Methyltransferase SET7/92011
- Author(s)
  Mori, S.
- Organizer
  AIMECS
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790127

1. Kurebayashi Nagomi (50133335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 村山尚 (10230012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 村越伸行 (80447218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. INOUE Yukiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. TO Seikon

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 国広なごみ

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
7. 小比類巻生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 石田良典

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 森本幸生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shuichi Mori 森 修一

MORI Shuichi 森 修一

Research Projects

Research Products

Co-Researchers

Effectiveness of RyR2 inhibitors as antiarrhytmic drugs

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel structural elements bearing hexa-coordinated sulfur fluorides and application to nuclear receptor-ligandsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of the method for screening histone methyl transferase inhibitors utilizing the novel fluorescent probe.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] NRSF- GNAO1 Pathway Contributes to the Regulation of Cardiac Ca 2+ Homeostasis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca2+ dynamics in primary skeletal myocytes2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of a water-soluble ryanodine receptor 1 inhibitor2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differential effects of the formin inhibitor SMIFH2 on contractility and Ca 2+ handling in frog and mouse cardiomyocytes2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural development of a type-1 ryanodine receptor (RyR1) Ca2+-release channel inhibitor guided by endoplasmic reticulum Ca2+ assay2019

Author(s)

Journal Title

DOI

Data Source

[Patent] ２型リアノジン受容体活性抑制剤2022

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] ２型リアノジン受容体活性抑制剤2021

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] ２型リアノジン受容体活性抑制剤2020

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] CPVTモデルマウスに対するRyR2特異的阻害薬の効果2021

Author(s)

Organizer

Shuichi Mori 森修一

MORI Shuichi 森修一

[Presentation] Discrimination between lysine and N--methyllysine using SNAr reactions2013