YAMADA TADAAKI 山田忠明

… Alternative Names

山田忠明ヤマダタダアキ

YAMADA Tadaaki 山田忠明

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Researcher Number	00507048
Other IDs
Affiliation (Current)	2025: 京都府立医科大学, 医学(系)研究科(研究院), 准教授
Affiliation (based on the past Project Information) *help	2023: 京都府立医科大学, 医学(系)研究科(研究院), 准教授 2020 – 2021: 京都府立医科大学, 医学(系)研究科(研究院), 准教授 2019 – 2020: 京都府立医科大学, 医学(系)研究科(研究院), 講師 2013: 金沢大学, 附属病院, 講師 2012: 金沢大学, 大学病院, 講師 2009 – 2011: 金沢大学, 附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine Except Principal Investigator Basic Section 28040:Nanobioscience-related / Respiratory organ internal medicine
Keywords	Principal Investigator 治療抵抗性 / EGFR / 薬剤耐性 / 足場蛋白質 / 分子標的治療 / 肺癌 / がん分子標的薬 / 低酸素血症 / 肺がん / 癌分子標的治療 … More / ALK / がん分子標的治療 / 治療標的 / 悪性胸膜中皮腫 / 上皮成長因子受容体 / がん分子標的 / EGFR変異 … More Except Principal Investigator Cancer cell / Imaging / Reactive Oxygen Species / redox biology / nano-sensor / hydrogen peroxides / SERS / nanosensor / cell surface pH / cell surface / Hydrogen peroxide / pH / Nanosensors / Raman spectroscopy / ゲフィチニブ / 上皮成長因子受容体 / 線維芽細胞 / MET / 肝細胞増殖因子 / 公子標的治療 / PI3K / バイオマーカー / EGFR遺伝子変異 / Met / HGF / 薬剤耐性 / EGFR-TKI / 肺癌 Less

Elucidation of drug resistance by the hypoxic environment adaptation mechanism in lung cancer and development of novel therapeutic strategyPrincipal Investigator
- Principal Investigator
  
  山田忠明
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kyoto Prefectural University of Medicine
Nanometer scale resolution imaging of pH and reactive oxygen species on the outer membrane surface for fast and effective cell discrimination in cancer tissues.
- Principal Investigator
  
  Puppulin Leonardo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 28040:Nanobioscience-related
- Research Institution
  Kanazawa University
Development of novel therapy and diagnosis targeted for signal transduction regarding drug tolerance in lung cancerPrincipal Investigator
- Principal Investigator
  
  YAMADA TADAAKI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kyoto Prefectural University of Medicine
新規足場蛋白Aki1による悪性胸膜中皮腫制御を目指した研究Principal Investigator
- Principal Investigator
  
  山田忠明
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kanazawa University
Akt kinase-interacting protein1, a novel therapeutic target for lung cancer with EGFR-activating and gatekeeper mutationsPrincipal Investigator
- Principal Investigator
  
  YAMADA Tadaaki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kanazawa University
Development of individual therapy for overcoming HGF-induced molecular targeted drug-resistance in EGFR-mutant lung cancer
- Principal Investigator
  
  YANO Seiji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kanazawa University

All 2024 2023 2022 2021 2020 2019 2018 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book

[Book] EGFR阻害薬についての研究の動向2021
- Author(s)
  山田忠明
- Total Pages
  7
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-19K08608
[Book] 肺がん分子標的治療の進歩2021
- Author(s)
  山田忠明
- Total Pages
  11
- Publisher
  京都府立医科大学雑誌
- Data Source
  KAKENHI-PROJECT-19K08608
[Book] 日本臨牀　最新肺癌学2013
- Author(s)
  山田　忠明
- Total Pages
  4
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-23790902
[Book] 実験医学2013
- Author(s)
  山田忠明,矢野聖二
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23790902
[Book] 実験医学2012
- Author(s)
  山田　忠明
- Total Pages
  6
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23790902
[Book] 「Mebio」肺がん治療20122012
- Author(s)
  山田　忠明
- Total Pages
  7
- Publisher
  メジカルレビュー社
- Data Source
  KAKENHI-PROJECT-23790902
[Book] がん生物学　イラストレイテッド2011
- Author(s)
  山田　忠明
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23790902
[Book] がん生物学イラストレイテッド2011
- Author(s)
  山田忠明,矢野聖二
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23790902
[Journal Article] Effects of combined therapeutic targeting of AXL and ATR on pleural mesothelioma cells2024
- Author(s)
  Hirai S, Yamada T, Katayama Y, Ishida M, Kawachi H, Matsui Y, Nakamura R, Morimoto K, Horinaka M, Sakai T, Sekido Y, Tokuda S, Takayama K
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 23 Issue: 2 Pages: 212-222
- DOI
  10.1158/1535-7163.mct-23-0138
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18407, KAKENHI-PROJECT-23K07607, KAKENHI-PROJECT-21K15513, KAKENHI-PROJECT-19H01079
[Journal Article] AXL signal mediates adaptive resistance to KRAS G12C inhibitors in KRAS G12C-mutant tumor cells.2024
- Author(s)
  Morimoto K, Yamada T, Hirai S, Katayama Y, Fukui S, Sawada R, Tachibana Y, Matsui Y, Nakamura R, Ishida M, Kawachi H, Kunimasa K, Sasaki T, Nishida M, Furuya N, Watanabe S, Shiotsu S, Nishioka N, Horinaka M, Sakai T, Uehara H, Yano S, Son BK, Tokuda S, Takayama K.
- Journal Title
  
  Cancer Lett
  
  Volume: 587 Pages: 216692-216692
- DOI
  10.1016/j.canlet.2024.216692
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07607, KAKENHI-PROJECT-21K15513, KAKENHI-PROJECT-22K20833, KAKENHI-PROJECT-23K27609
[Journal Article] Analysis of Tumor Heterogeneity Through AXL Activation in Primary Resistance to EGFR Tyrosine Kinase Inhibitors.2023
- Author(s)
  Nakamura R, Fujii H, Yamada T, Matsui Y, Yaoi T, Honda M, Tanaka N, Miyagawa-Hayashino A, Yoshimura A, Morimoto K, Iwasaku M, Tokuda S, Kim YH, Konishi E, Itoh K, Takayama K.
- Journal Title
  
  JTO Clin Res Rep
  
  Volume: 4 Issue: 6 Pages: 100525-100525
- DOI
  10.1016/j.jtocrr.2023.100525
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07607
[Journal Article] HER3 activation contributes toward the emergence of ALK inhibitor-tolerant cells in ALK-rearranged lung cancer with mesenchymal features.2022
- Author(s)
  Tanimura K, Yamada T, Okada K, Nakai K, Horinaka M, Katayama Y, Morimoto K, Ogura Y, Takeda T, Shiotsu S, Ichikawa K, Watanabe S, Morimoto Y, Iwasaku M, Kaneko Y, Uchino J, Taniguchi H, Yoneda K, Matoba S, Sakai T, Uehara H, Yano S, Kusaba T, Katayama R, Takayama K.
- Journal Title
  
  NPJ Precis Oncol.
  
  Volume: 6 Issue: 1 Pages: 5-5
- DOI
  10.1038/s41698-021-00250-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08608, KAKENHI-PROJECT-20K21554, KAKENHI-PROJECT-20K22820, KAKENHI-PLANNED-17H06398, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-19H03524, KAKENHI-PROJECT-19H03889, KAKENHI-PROJECT-20K08640
[Journal Article] Inhibition of c-Jun N-terminal kinase signaling increased apoptosis and prevented the emergence of ALK-TKI-tolerant cells in ALK-rearranged non-small cell lung cancer.2021
- Author(s)
  Tanimura K, Yamada T, Horinaka M, Katayama Y, Fukui S, Morimoto K, Nakano T, Tokuda S, Morimoto Y, Iwasaku M, Kaneko Y, Uchino J, Yoneda K, Yano S, Sakai T, Takayama K.
- Journal Title
  
  Cancer Lett.
  
  Volume: 522 Pages: 119-128
- DOI
  10.1016/j.canlet.2021.09.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08608, KAKENHI-PLANNED-17H06398, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-19H03889
[Journal Article] Plasma membrane anchored nanosensor for quantifying endogenous production of H2O2 in living cells2021
- Author(s)
  Hosogi Shigekuni、Marunaka Yoshinori、Ashihara Eishi、Yamada Tadaaki、Sumino Ayumi、Tanaka Hideo、Puppulin Leonardo
- Journal Title
  
  Biosensors and Bioelectronics
  
  Volume: 179 Pages: 113077-113077
- DOI
  10.1016/j.bios.2021.113077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05228, KAKENHI-PROJECT-18K19422, KAKENHI-PROJECT-18H03182
[Journal Article] Impact of tumor programmed death ligand-1 expression on osimertinib efficacy in untreated EGFR-mutated advanced non-small cell lung cancer: a prospective observational study.2021
- Author(s)
  Yoshimura A, Yamada T, Okuma Y, Fukuda A, Watanabe S, Nishioka N, Takeda T, Chihara Y, Takemoto S, Harada T, Hiranuma O, Shirai Y, Nishiyama A, Yano S, Goto Y, Shiotsu S, Kunimasa K, Morimoto Y, Iwasaku M, Kaneko Y, Uchino J, Kenmotsu H, Takahashi T, Takayama K.
- Journal Title
  
  Transl Lung Cancer Res.
  
  Volume: 10 Issue: 8 Pages: 3582-3593
- DOI
  10.21037/tlcr-21-461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08608
[Journal Article] ONO-7475, a Novel AXL Inhibitor, Suppresses the Adaptive Resistance to Initial EGFR-TKI Treatment in EGFR-Mutated Non?Small Cell Lung Cancer2020
- Author(s)
  Okura N, Nishioka N, Yamada T, Taniguchi H, Tanimura K, Katayama Y, Yoshimura A, Watanabe S, Kikuchi T, Shiotsu S, Kitazaki T, Nishiyama A, Iwasaku M, Kaneko Y, Uchino J, Uehara H, Horinaka M, Sakai T, Tanaka K, Kozaki R, Yano S, Takayama K.
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 26 Issue: 9 Pages: 2244-2256
- DOI
  10.1158/1078-0432.ccr-19-2321
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KT0019, KAKENHI-PLANNED-17H06398, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-19K08608, KAKENHI-PROJECT-19H03889, KAKENHI-PROJECT-23K20323
[Journal Article] Taniguchi H, Yamada T, Wang R, Tanimura K, Adachi Y, Nishiyama A, Tanimoto A, Takeuchi S, Araujo LH, Boroni M, Yoshimura A, Shiotsu S, Matsumoto I, Watanabe S, Kikuchi T, Miura S, Tanaka H, Kitazaki T, Yamaguchi H, Mukae H, Uchino J, Uehara H, Takayama K, Yano S.2018
- Author(s)
  Taniguchi H, Yamada T, Wang R, Tanimura K, Adachi Y, Nishiyama A, Tanimoto A, Takeuchi S, Araujo LH, Boroni M, Yoshimura A, Shiotsu S, Matsumoto I, Watanabe S, Kikuchi T, Miura S, Tanaka H, Kitazaki T, Yamaguchi H, Mukae H, Uchino J, Uehara H, Takayama K, Yano S.
- Journal Title
  
  Nat Commun.
  
  Volume: 10 Issue: 1 Pages: 259-259
- DOI
  10.1038/s41467-018-08074-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09649, KAKENHI-PROJECT-16H05308, KAKENHI-PROJECT-18KT0019, KAKENHI-PROJECT-19K08608, KAKENHI-PROJECT-19H03665
[Journal Article] EGFR-TKI resistance due to BIM polymorphism can be circumvented　in　combination with HDAC inhibition.2013
- Author(s)
  Nakagawa T, Yano S, et al.
- Journal Title
  
  Cancer Res
  
  Volume: 73 Issue: 8 Pages: 2428-34
- DOI
  10.1158/0008-5472.can-12-3479
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22112010, KAKENHI-PROJECT-23790902, KAKENHI-PROJECT-24390209, KAKENHI-PROJECT-25860638, KAKENHI-PROJECT-25860640, KAKENHI-ORGANIZER-22112001
[Journal Article] mTOR inhibitors control erlotinib-resistance of EGFR mutant lung cancer cells triggered by HGF.2013
- Author(s)
  Ishikawa D, Yano S, et al.
- Journal Title
  
  PLoS ONE
  
  Volume: 8 Issue: 5 Pages: e62104-e62104
- DOI
  10.1371/journal.pone.0062104
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22112010, KAKENHI-PROJECT-23591141, KAKENHI-PROJECT-24300329, KAKENHI-PROJECT-24390209, KAKENHI-PROJECT-24591156, KAKENHI-PROJECT-25860638, KAKENHI-PROJECT-25860640
[Journal Article] Akt kinase-interacting protein1, a novel therapeutic target for lung cancer with EGFR activating and gatekeeper mutations.2013
- Author(s)
  Yamada T, Yano S, et al.
- Journal Title
  
  Oncogene
  
  Volume: 32 Issue: 37 Pages: 4427-35
- DOI
  10.1038/onc.2012.446
- NAID
  120004997024
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22112010, KAKENHI-PROJECT-23790902, KAKENHI-PROJECT-24300344, KAKENHI-PROJECT-24390209, KAKENHI-PROJECT-24390210, KAKENHI-PROJECT-25860638, KAKENHI-PLANNED-22112008
[Journal Article] The novel phosphoinositide 3-kinase-mammalian target of rapamycin inhibitor, BEZ235, circumvents erlotinib resistance of epidermal growth factor receptor mutant lung cancer cells triggered by hepatocyte growth factor.2013
- Author(s)
  Sano T, Yano S, et al.
- Journal Title
  
  Int J Cancer
  
  Volume: 133 Issue: 2 Pages: 505-13
- DOI
  10.1002/ijc.28034
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22112010, KAKENHI-PROJECT-23790327, KAKENHI-PROJECT-23790903, KAKENHI-PROJECT-24300329, KAKENHI-PROJECT-24390209, KAKENHI-PROJECT-25860638
[Journal Article] Paracrine receptor activation by microenvironment triggers bypass survival signals and ALK inhibitor resistance in EML4-ALK lung cancer cells2012
- Author(s)
  Yamada, T.
- Journal Title
  
  Clin. Cancer Res.
  
  Volume: 18 Issue: 13 Pages: 3592-3602
- DOI
  10.1158/1078-0432.ccr-11-2972
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689043, KAKENHI-PROJECT-23790327, KAKENHI-PROJECT-23790902, KAKENHI-PROJECT-23790903, KAKENHI-PROJECT-24300329, KAKENHI-PROJECT-24659403
[Journal Article] Hsp90 inhibition overcomes HGF-triggering resistance to EGFR-TKIs in EGFR mutant lung cancer by decreasing client protein expression and angiogenesis2012
- Author(s)
  Koizumi H, Yamada T, Takeuchi S, Nakagawa T, Kita K, Nakamura T, Matsumoto K, Suda K, Mitsudomi T, Yano S.
- Journal Title
  
  J Thorac Oncol
  
  Volume: (in press)
- NAID
  40019570662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256
[Journal Article] Hsp90 Inhibition Overcomes HGF Triggering Resistance to EGFR-TKIs in EGFR-Mutant Lung Cancer by Decreasing Client Protein Expression and Angiogenesis2012
- Author(s)
  Koizumi H, Yamada T, Takeuchi S, Nakagawa T, Kita K, Nakamura T, Matsumoto K, Suda K, Mitsudomi T, and Yano S
- Journal Title
  
  Journal of Thoracic Oncology
  
  Volume: Vol. 7: no.7 Issue: 7 Pages: 1078-1085
- DOI
  10.1097/jto.0b013e3182519a2c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790327, KAKENHI-PROJECT-23790902, KAKENHI-PROJECT-23790903, KAKENHI-PROJECT-24300329, KAKENHI-PROJECT-24390209, KAKENHI-PROJECT-24659403, KAKENHI-PLANNED-22112010
[Journal Article] Hepatocyte growth factor induces resistance to anti-epidermal growth factor receptor antibody in lung cancer2012
- Author(s)
  Yamada T, Takeuchi S, Kita K, Bando H, Nakamura T, Matsumoto K, Yano S
- Journal Title
  
  J Thorac Oncol
  
  Volume: 7 Issue: 2 Pages: 272-80
- DOI
  10.1097/jto.0b013e3182398e69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256, KAKENHI-PLANNED-22112010, KAKENHI-PROJECT-23790327, KAKENHI-PROJECT-23790902, KAKENHI-PROJECT-24300329, KAKENHI-PROJECT-24390209
[Journal Article] E7050, a Met kinase inhibitor, reverses three different mechanisms of hepatocyte growth factor-induced resistance to tyrosine kinase inhibitors in EGFR mutant lung cancer cells2012
- Author(s)
  Wang W, Li Q, Takeuchi S, Yamada T, Koizumi H, Nakamura T, Matsumoto K, Mukaida N, Nishioka Y, Sone S, Uenaka T, Yano S
- Journal Title
  
  Clin Cancer Res
  
  Volume: 18 Issue: 6 Pages: 1663-71
- DOI
  10.1158/1078-0432.ccr-11-1171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256, KAKENHI-PLANNED-22112010, KAKENHI-PROJECT-22390166, KAKENHI-PROJECT-23790327, KAKENHI-PROJECT-23790902, KAKENHI-PROJECT-23790903, KAKENHI-PROJECT-24300329, KAKENHI-PROJECT-24390209, KAKENHI-PROJECT-24390210
[Journal Article] Ligand-triggered resistance to molecular targeted drugs in lung cancer : roles of HGF and EGFR ligands2012
- Author(s)
  Yano S, Takeuchi S, Nakagawa T, Yamada T
- Journal Title
  
  Cancer Sci
  
  Volume: (In press) Issue: 7 Pages: 1189-1194
- DOI
  10.1111/j.1349-7006.2012.02279.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256, KAKENHI-PLANNED-22112010, KAKENHI-PROJECT-23790902, KAKENHI-PROJECT-23790903
[Journal Article] Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer2011
- Author(s)
  Donev IS, Wang W, Yamada T, Li Q, Takeuchi S, Matsumoto K, Yamori T, Nishioka Y, Sone S, Yano S
- Journal Title
  
  Clin Cancer Res
  
  Volume: 17 Issue: 8 Pages: 2260-9
- DOI
  10.1158/1078-0432.ccr-10-1993
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256, KAKENHI-PLANNED-22112010, KAKENHI-PROJECT-22240092, KAKENHI-PROJECT-23790902, KAKENHI-PROJECT-23790903
[Journal Article] Pleural mesothelioma instigates tumor associated fibroblasts to promote prog-ression via malignant cytokine network2011
- Author(s)
  Li Q, Wang W, Yamada T, Matsumoto K, Bando Y, Uehara H, Nishioka Y, Sone S, Iwakiri S, Itoi K, Utsugi T, Yano S.
- Journal Title
  
  Am J Pathol
  
  Volume: 179 Issue: 3 Pages: 1483-93
- DOI
  10.1016/j.ajpath.2011.05.060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256, KAKENHI-PLANNED-22112010, KAKENHI-PROJECT-22390166, KAKENHI-PROJECT-23659434, KAKENHI-PROJECT-23790221, KAKENHI-PROJECT-23790902
[Journal Article] Genetically engineered humanized anti-ganglioside GM2 anti-body against multiple organ metastasis produced by GM2 expressing small cell lung cancer2011
- Author(s)
  Yamada T, Bando H, Takeuchi S, Kita K, Li Q, Wang W, Akinaga S, Nishioka Y, Sone S, Yano S.
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Issue: 12 Pages: 2157-63
- DOI
  10.1111/j.1349-7006.2011.02093.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256, KAKENHI-PLANNED-22112010, KAKENHI-PROJECT-22390166, KAKENHI-PROJECT-23790902, KAKENHI-PROJECT-23790903
[Journal Article] E7080 suppresses hematogenous multiple organ metastases of lung cancer cells with nonmutated epidermal growth factor receptor2011
- Author(s)
  Ogino H, Hanibuchi M, Kakiuchi S, Trung Van The, Goto H, Ikuta K, Yamada T, Uehara H, Tsuruoka A, Uenaka T, Wang W, Li Q, Takeuchi S, Yano S, Nishioka Y, Sone S.
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 10 Issue: 7 Pages: 1218-28
- DOI
  10.1158/1535-7163.mct-10-0707
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256, KAKENHI-PLANNED-22112010, KAKENHI-PROJECT-22390166, KAKENHI-PROJECT-23790902, KAKENHI-PROJECT-23790903
[Journal Article] The EGFR ligands amphiregulin and heparin-binding EGF-like growth factor promote peritoneal carcinomatosis in CXCR4-expressing gastric cancer2011
- Author(s)
  Yasumoto K, Yamada T, Kawashima A, Wang W, Li Q, Donev IS, Takeuchi S, Mouri H, Yamashita K, Ohtsubo K, Yano S.
- Journal Title
  
  Clin Cancer Res
  
  Volume: 17 Issue: 11 Pages: 3619-30
- DOI
  10.1158/1078-0432.ccr-10-2475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256, KAKENHI-ORGANIZER-22112001, KAKENHI-PLANNED-22112010, KAKENHI-PROJECT-23591921, KAKENHI-PROJECT-23790902
[Journal Article] Hepatocyte growth factor expression in EGFR mutant lung cancer with intrinsic and acquired resistance to tyrosine kinase inhibitors in a Japanese cohort2011
- Author(s)
  Yano S, Yamada T, Takeuchi S, Tachibana K, Minami Y, Yatabe Y, Mitsudomi T, Tanaka H, Kimura T, Kudoh S, Nokihara H, Ohe Y, Yokota J, Uramoto U, Yasumoto Y, Kiura K, Higashiyama M, Oda M, Saito H, Yoshida J, Kondoh K, Noguchi M.
- Journal Title
  
  J Thorac Oncol
  
  Volume: 6 Issue: 12 Pages: 2011-7
- DOI
  10.1097/jto.0b013e31823ab0dd
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256, KAKENHI-PROJECT-21591831, KAKENHI-PLANNED-22112010, KAKENHI-PROJECT-23790902, KAKENHI-PROJECT-23790903
[Journal Article] Hepatocyte growth factor reduces susceptibility to irreversible epidermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancer.2010
- Author(s)
  Yamada T, et al.
- Journal Title
  
  Clin Cancer Res 16
  
  Pages: 174-183
- NAID
  120001939468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256
[Journal Article] Hepatocyte growth factor reduces susceptibility to irreversible epidermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancer2010
- Author(s)
  Yamada T, Matsumoto K, Wang W, Li Q, NishiokaY, Sekido Y, Sone S, Yano S.
- Journal Title
  
  Clin Cancer Res
  
  Volume: 16 Issue: 1 Pages: 174-83
- DOI
  10.1158/1078-0432.ccr-09-1204
- NAID
  120001939468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256
[Journal Article] Hepatocvte growth factor reduces susceptibility to an irreversible epidermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancer.2010
- Author(s)
  Yamada T, Yano S, et al.
- Journal Title
  
  Clin Cancer Res
  
  Volume: 16 Pages: 174-183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256
[Journal Article] Metastatic renal cell carcinoma complicated with diffuse alveolar hemorrhage : a rare adverse effect of sunitinib.2010
- Author(s)
  Yamada T, Yano S, et al.
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 15 Pages: 638-641
- NAID
  10027665563
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256
[Journal Article] Crosstalk to stromal fibroblasts induces resistance of lung cancer to EGFR tyrosine kinase inhibitors2009
- Author(s)
  Wang W, Li Q, Yamada T, Matsumoto K, Matsumoto I, Oda M, Watanabe G, Kayano Y, Nishioka Y, Sone S, Yano S
- Journal Title
  
  Clin Cancer Res
  
  Volume: 15 Issue: 21 Pages: 6630-8
- DOI
  10.1158/1078-0432.ccr-09-1001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256
[Journal Article] Combined chemotherapy with carboplatin plus irinotecan showed favorable efficacy in a patient with relapsed small cell carcinoma of the prostate complicated with meningeal carcinomatosis.2009
- Author(s)
  Yamada T, et al.
- Journal Title
  
  Int J Clin Oncol 14
  
  Pages: 468-472
- NAID
  10027201066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256
[Journal Article] E7080, a multi-tyrosine kinase inhibitor, suppresses the progression of malignant pleural mesothelioma with different proangio-genic cytokine production profiles2009
- Author(s)
  Ikuta K, Yano S, Trung TV, Hanibuchi M, Goto H, Li Q, Wang W, Yamada T, Ogino H, Kakiuchi S, Uehara H, Sekido Y, Uenaka T, Nishioka Y, Sone S
- Journal Title
  
  Clin Cancer Res
  
  Volume: 15 Issue: 23 Pages: 7229-37
- DOI
  10.1158/1078-0432.ccr-09-1980
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256
[Journal Article] Intensification therapy with anti-parathyroid hormone-related protein antibody plus zoledronic acid for bone metastases of small cell lung cancer cells in SCID mice.2009
- Author(s)
  Yamada T, et al.
- Journal Title
  
  Mol Cancer Ther 8
  
  Pages: 119-126
- NAID
  120001088425
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256
[Journal Article] Intensification therapy with anti-para-thyroid hormonerelated protein antibody plus zoledronic acid for bone metastases of small cell lung cancer cells in SCID mice2009
- Author(s)
  Yamada T, Muguruma H, Yano S, Ikuta K, Ogino H, Kakiuchi S, Hanibuchi M, Uehara H, Nishioka Y, Sone S.
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 8 Pages: 119-26
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/19139120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390256
[Presentation] がん分子標的薬抵抗性を標的とした治療法開発2024
- Author(s)
  山田忠明
- Organizer
  第21回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07607
[Presentation] Targeting AXL and MCL-1 to eradicate Lazertinib tolerance in EGFR-mutated NSCLC cells2024
- Author(s)
  Tadaaki Yamada, Yohei Matsui, Koichi Takayama
- Organizer
  アメリカ癌学会 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07607
[Presentation] AXLを標的としたEGFR遺伝子変異肺がんの初期併用治療法の臨床開発に向けた取り組み2023
- Author(s)
  山田忠明、矢野聖二、髙山浩一
- Organizer
  第64回日本肺癌学会総会
- Data Source
  KAKENHI-PROJECT-23K07607
[Presentation] Roles of p53 and AXL expressions on the efficacy of ICI-based therapy in patients with EGFR mutated lung cancer after osimertinib2023
- Author(s)
  Tadaaki Yamada, Kenji Morimoto, Koichi Azuma, Yasuhiro Goto, Taishi Harada, Shinsuke Shiotsu, Nobuyo Tamiya, Yusuke Chihara, Takayuki Takeda, Osamu Hiranuma, Isao Hasegawa, Koichi Takayama
- Organizer
  IASLC2023 World Conference on Lung Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07607
[Presentation] Role of AXL activation on adaptive resistance to KRAS-G12C inhibitors in KRAS-G12C-mutated non-small cell lung cancer2023
- Author(s)
  Tadaaki Yamada, Kenji Morimoto, Soichi Hirai, Yuki Katayama, Kei Kunimasa, Takaaki Sasaki, Naoki Furuya, Satoshi Watanabe, Shinsuke Shiotsu, Hisanori Uehara, Koichi Takayama
- Organizer
  欧州臨床腫瘍学会 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07607
[Presentation] Impact of PD-L1 expression on osimertinib efficacy in untreated EGFR-mutated NSCLC: a prospective observational study2022
- Author(s)
  西岡直哉, 山田忠明, 吉村彰紘, 大熊裕介, 福田滉仁, 渡部聡, 竹田隆之, 千原佑介, 竹本真之輔, 原田大司, 平沼修, 白井由紀奈, 西山明宏, 矢野聖二, 後藤康洋, 塩津伸介, 國政啓, 釼持広知, 高橋利明, 高山浩一
- Organizer
  第19回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08608
[Presentation] 肺がん分子標的治療の耐性克服2022
- Author(s)
  山田忠明、髙山浩一
- Organizer
  第62回日本呼吸器学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08608
[Presentation] Activation of HER3 signal yields tolerant cells to ALK inhibitors in ALK-rearranged lung cancer2021
- Author(s)
  Keiko Tanimura, Tadaaki Yamada, Kohtaroh Okada, Kazue Yoneda, Junji Uchino, Ryohei Katayama, Koichi Takayama
- Organizer
  第25回アジア太平洋呼吸器学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08608
[Presentation] EGFR遺伝子変異陽性肺がんにおけるEGFR-TKI耐性後の治療戦略2021
- Author(s)
  山田忠明、髙山浩一
- Organizer
  第62回日本肺癌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08608
[Presentation] EGFR遺伝子変異陽性非小細胞肺がんのオシメルチニブ初回治療における腫瘍内AXL発現の意義を検討する多施設共同前向き観察研究2021
- Author(s)
  吉村彰紘、山田忠明、谷村恵子、大熊裕介、福田滉仁、渡部聡、西岡直哉、竹田隆之、千原佑介、竹本真之輔、原田大司、平沼修、白井由紀奈、西山明宏、矢野聖二、後藤康洋、塩津伸介、國政啓、釼持広知、高橋利明、髙山浩一
- Organizer
  第62回日本肺癌学会総会
- Data Source
  KAKENHI-PROJECT-19K08608
[Presentation] ドライバー遺伝子変異肺癌の治療抵抗性克服を目指した新規治療法の開発2021
- Author(s)
  山田忠明、髙山浩一
- Organizer
  第80回日本癌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08608
[Presentation] Novel therapeutic strategies for drug tolerance in NSCLC with driver oncogenes2021
- Author(s)
  Tadaaki Yamada, Seiji Yano
- Organizer
  第18回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08608
[Presentation] ONO-7475, a novel AXL inhibitor, suppresses the emergence and maintenance of tolerant cells to initial EGFR-TKI treatment in EGFR-mutated non-small lung cancer2021
- Author(s)
  Tadaaki Yamada, Naoko Okura, Naoya Nishioka, Hirokazu Taniguchi, Kohei Tanaka, Ryohei Kozaki, Seiji Yano, Koichi Takayama
- Organizer
  第25回アジア太平洋呼吸器学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08608
[Presentation] Driver遺伝子変異肺がんにおける初期治療抵抗性機構の解明2020
- Author(s)
  山田忠明
- Organizer
  第61回日本肺癌学会総会
- Data Source
  KAKENHI-PROJECT-19K08608
[Presentation] AXL confers intrinsic resistance to osimertinib and the emergence of tolerant cells2019
- Author(s)
  Hirokazu Taniguchi, Tadaaki Yamada, Rong Wang, Keiko Tanimura, Akihiro Nishiyama, Azusa Tanimoto, Yuta Adachi, Shinji Takeuchi, Hiroyuki Yamaguchi, Minoru Fukuda, Koichi Takayama, Hiroshi Mukae, Seiji Yano
- Organizer
  第110回アメリカ癌学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08608
[Presentation] Paracrine receptor ligands activate bypass tracts and cause ALK inhibitor resistance in EML4-ALK lung cancer cells2012
- Author(s)
  山田　忠明
- Organizer
  5th Asia Pacific Lung Cancer Conference
- Place of Presentation
  ヒルトン福岡シーホーク（福岡県）
- Data Source
  KAKENHI-PROJECT-23790902
[Presentation] ALK肺がんのLigandによるALK阻害薬耐性機構とその克服2012
- Author(s)
  山田　忠明
- Organizer
  第53回日本肺癌学会総会
- Place of Presentation
  岡山コンベンションセンター（岡山県）
- Data Source
  KAKENHI-PROJECT-23790902
[Presentation] EGFR遺伝子変異陽性肺がんにおける新規足場蛋白Aki1の制御2012
- Author(s)
  山田忠明ら
- Organizer
  第71回日本癌学会総会(一般口演)
- Place of Presentation
  ホテルロイトン札幌(北海道)
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-23790902
[Presentation] Hsp90 inhibition overcomes HGF-triggering resistance to EGFR-TKIs in EGFR mutant lung cancer by decreasing client protein expression and angiogenesis2012
- Author(s)
  Yamada T, et al.
- Organizer
  103thAmerican Association for Cancer Research Annual Meeting (Poster)
- Place of Presentation
  McCormick Place(USA)
- Year and Date
  2012-04-02
- Data Source
  KAKENHI-PROJECT-23790902
[Presentation] 非小細胞肺がんにおけるEGFR-TKI耐性2012
- Author(s)
  山田忠明,矢野聖二
- Organizer
  第10回日本臨床腫瘍学会学術総会(シンポジウム)
- Place of Presentation
  大阪国際会議場(大阪府)
- Year and Date
  2012-07-27
- Data Source
  KAKENHI-PROJECT-23790902
[Presentation] ALK肺がんのLigandによるALK阻害薬耐性機構とその克服2012
- Author(s)
  山田忠明ら
- Organizer
  第53回日本肺癌学会総会(ワークショップ)
- Place of Presentation
  岡山コンベンションセンター(岡山県)
- Year and Date
  2012-11-08
- Data Source
  KAKENHI-PROJECT-23790902
[Presentation] Paracrine receptor ligands activate bypass tracts and cause ALK inhibitor resistance in EML4-ALK lung cancer cells2012
- Author(s)
  Yamada T, et al.
- Organizer
  5th Asia Pacific Lung Cancer Conference(oral presentation)
- Place of Presentation
  ヒルトン福岡シーホーク(福岡県)
- Year and Date
  2012-11-27
- Data Source
  KAKENHI-PROJECT-23790902
[Presentation] Hepatocyte growth factor induces resistance to anti-epidermal growth factor receptor antibody in lung cancer.2012
- Author(s)
  Tadaaki Yamada
- Organizer
  16th JFCR International Symposium on Cancer Chemotherapy
- Place of Presentation
  日本科学未来館（東京都）
- Data Source
  KAKENHI-PROJECT-23790902
[Presentation] Treatment for EGFR mutant lung cancer2011
- Author(s)
  山田　忠明
- Organizer
  第9回日本臨床腫瘍学会学術総会(招待講演)
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-23790902
[Presentation] EML4-ALK肺がんにおけるALK阻害薬耐性：EGFRリガンドによる新規耐性機構2011
- Author(s)
  山田　忠明
- Organizer
  第52回日本肺癌学会総会
- Place of Presentation
  大阪国際会議場（大阪府）
- Data Source
  KAKENHI-PROJECT-23790902
[Presentation] HGF/MET is a novel therapiutic target for EGFR-TKI resistant lung cancer2011
- Author(s)
  Yamada T, Yano S
- Organizer
  第70回日本癌学会総会(International Session)
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-23790902
[Presentation] Hepatocyte growth factor expression in EGFR mutant lung cancer with intrinsic and acquired resistance to tyrosine kinase inhibitors in a Japanese cohort. 2011 American Society of Clinical Oncology(ASCO)2011
- Author(s)
  Yano S, Yamada T, Takeuchi S, Tachibana K, Minami Y, Yatabe Y, Mitsudomi T, Tanaka H, Kimura T, Kudoh S, Nokihara H, Ohe Y, Yokota J, Uramoto H, Yasumoto K, Kiura K, Higashiyama M, Oda M, Saito H, Yoshida J, Kondoh K
- Organizer
  Annual Meeting
- Place of Presentation
  McCormick Place(USA.)
- Year and Date
  2011-06-04
- Data Source
  KAKENHI-PROJECT-21390256
[Presentation] Hsp90阻害剤は、HGFによるEGFR遺伝子変異陽性肺がんの薬剤耐性を克服する2011
- Author(s)
  山田　忠明
- Organizer
  第11回日本分子生物学会春季シンポジウム
- Place of Presentation
  石川県立音楽堂（石川県）
- Data Source
  KAKENHI-PROJECT-23790902
[Presentation] HGF/MET is a novel therapiutic target for EGFR-TKI resistant lung cancer2011
- Author(s)
  Tadaaki Yamada
- Organizer
  第70回日本癌学会総会(招待講演)
- Place of Presentation
  名古屋国際会議場(（愛知県）
- Data Source
  KAKENHI-PROJECT-23790902
[Presentation] Treatment for EGFR mutant lung cancer2011
- Author(s)
  山田忠明,矢野聖二
- Organizer
  第9回日本臨床腫瘍学会学術総会(シンポジウム)
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-07-21
- Data Source
  KAKENHI-PROJECT-23790902
[Presentation] CDDPの心嚢腔内投与が奏効した肺扁平上皮癌による心タンポナーデ合併癌性心膜炎の一剖検例2011
- Author(s)
  山田　忠明
- Organizer
  第64回肺癌学会北陸支部会
- Place of Presentation
  福井大学医学部附属病院（福井県）
- Data Source
  KAKENHI-PROJECT-23790902
[Presentation] Analysis of tumor immunoreactivity for FGF-2,PDGF-AA, and HGF in malignant pleural mesothelioma patients2011
- Author(s)
  山田　忠明
- Organizer
  第9回日本臨床腫瘍学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-23790902
[Presentation] EGFR変異とEGFR-TKI:耐性克服の治療戦略.2009
- Author(s)
  山田忠明
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21390256
[Presentation] EGFR活性型変異を有する肺腺癌における肝細胞増殖因子(HGF)によるゲフィチニブ耐性.2009
- Author(s)
  山田忠明
- Organizer
  第49回日本呼吸器学会学術講演会
- Place of Presentation
  東京国際フォーラム(東京都)
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-21390256
[Presentation] 肝細胞増殖因子(HGF)はEGFR遺伝子変異T790Mを有する肺線癌のirreversible EGFR阻害剤の耐性を誘導する.2009
- Author(s)
  山田忠明
- Organizer
  第13回日本がん分子標的治療学会学術集会
- Place of Presentation
  ホテルクレメント徳島(徳島市)
- Year and Date
  2009-06-24
- Data Source
  KAKENHI-PROJECT-21390256
[Presentation] 肝細胞増殖因子(HGF)はEGFR遺伝子変異T790Mを有する肺腺癌のirreversible EGFR阻害剤の耐性を誘導する2009
- Author(s)
  山田忠明
- Organizer
  第50回日本肺癌学会総会
- Place of Presentation
  京王プラザホテル(東京都)
- Year and Date
  2009-11-12
- Data Source
  KAKENHI-PROJECT-21390256
[Presentation] 新規足場蛋白Aki1を標的としたEGFR遺伝子変異肺がんの制御
- Author(s)
  山田忠明
- Organizer
  第17回日本がん分子標的治療学会
- Place of Presentation
  京都国際会議場（京都府）
- Data Source
  KAKENHI-PROJECT-25860638
[Presentation] 非小細胞肺がんにおけるEGFR-TKI耐性
- Author(s)
  山田　忠明
- Organizer
  第10回日本臨床腫瘍学会学術総会
- Place of Presentation
  大阪国際会議場（大阪府）
- Invited
- Data Source
  KAKENHI-PROJECT-23790902
[Presentation] 非小細胞肺がんにおけるEGFR阻害薬耐性の機構解明とその克服に向けた研究
- Author(s)
  山田忠明
- Organizer
  第53回日本呼吸器学会総会
- Place of Presentation
  東京国際フォーラム（東京都）
- Data Source
  KAKENHI-PROJECT-25860638
[Presentation] EML4-ALK肺がんの肝細胞増殖因子による新たなALK阻害薬耐性機構
- Author(s)
  山田　忠明
- Organizer
  第16回日本がん分子標的治療学会
- Place of Presentation
  西日本総合展示場（福岡県）
- Data Source
  KAKENHI-PROJECT-23790902
[Presentation] Hsp90 inhibition overcomes HGF-triggering resistance to EGFR-TKIs in EGFR mutant lung cancer by decreasing client protein expression and angiogenesis
- Author(s)
  山田　忠明
- Organizer
  第103回アメリカ癌学会
- Place of Presentation
  McCormick Place（USA）
- Data Source
  KAKENHI-PROJECT-23790902
[Presentation] HGFによるEGFR変異陽性肺がんの薬剤耐性に対するHsp90阻害薬の治療効果
- Author(s)
  山田　忠明
- Organizer
  第52回日本呼吸器学会総会
- Place of Presentation
  神戸コンベンションセンター（兵庫県）
- Data Source
  KAKENHI-PROJECT-23790902
[Presentation] EGFR遺伝子変異陽性肺がんにおける新規足場蛋白Aki1の制御
- Author(s)
  山田　忠明
- Organizer
  第71回日本癌学会総会
- Place of Presentation
  ホテルロイトン札幌（北海道）
- Data Source
  KAKENHI-PROJECT-23790902

1. 高山浩一 (50274444)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
2. YANO Seiji (30294672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 21 results
3. WANG Wei (80467117)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
4. TAKEUCHI Shinji (90565384)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
5. Puppulin Leonardo (40771580)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 細木誠之 (30433254)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 内野順治 (80432946)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. 徳田深作 (00433277)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. HORINAKA Mano

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 中村隆弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 酒井敏行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 菊地利明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 阿部貴志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. プップリンレオナルド

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMADA TADAAKI 山田 忠明

山田 忠明 ヤマダ タダアキ

YAMADA Tadaaki 山田 忠明

Research Projects

Research Products

Co-Researchers

Elucidation of drug resistance by the hypoxic environment adaptation mechanism in lung cancer and development of novel therapeutic strategyPrincipal Investigator

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Nanometer scale resolution imaging of pH and reactive oxygen species on the outer membrane surface for fast and effective cell discrimination in cancer tissues.

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Development of novel therapy and diagnosis targeted for signal transduction regarding drug tolerance in lung cancerPrincipal Investigator

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新規足場蛋白Aki1による悪性胸膜中皮腫制御を目指した研究Principal Investigator

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Akt kinase-interacting protein1, a novel therapeutic target for lung cancer with EGFR-activating and gatekeeper mutationsPrincipal Investigator

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Development of individual therapy for overcoming HGF-induced molecular targeted drug-resistance in EGFR-mutant lung cancer

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[Book] EGFR阻害薬についての研究の動向2021

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[Book] 肺がん分子標的治療の進歩2021

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[Book] 日本臨牀 最新肺癌学2013

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[Book] 実験医学2013

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[Book] 実験医学2012

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[Book] 「Mebio」肺がん治療20122012

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[Book] がん生物学 イラストレイテッド2011

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[Book] がん生物学 イラストレイテッド2011

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[Journal Article] Effects of combined therapeutic targeting of AXL and ATR on pleural mesothelioma cells2024

YAMADA TADAAKI 山田忠明

山田忠明ヤマダタダアキ

YAMADA Tadaaki 山田忠明

[Book] 日本臨牀　最新肺癌学2013

[Book] がん生物学　イラストレイテッド2011

[Book] がん生物学イラストレイテッド2011

[Journal Article] EGFR-TKI resistance due to BIM polymorphism can be circumvented　in　combination with HDAC inhibition.2013