fukami tatsuki 深見達基

… Alternative Names

深見達基フカミタツキ

FUKAMI Tatsuki 深見達基

Less

Researcher Number	00532300
Other IDs
Affiliation (Current)	2025: 金沢大学, 薬学系, 准教授
Affiliation (based on the past Project Information) *help	2023: 金沢大学, 薬学系, 准教授 2014 – 2021: 金沢大学, 薬学系, 准教授 2009 – 2013: Kanazawa University, 薬学系, 助教
Review Section/Research Field	Principal Investigator Medical pharmacy / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related Except Principal Investigator Applied pharmacology
Keywords	Principal Investigator 薬物毒性 / 加水分解酵素 / 薬物代謝 / 脂質代謝 / 薬物代謝酵素 / 加水分解 / 鉄代謝 / 鉄 / 肝障害 / フェロトーシス … More / AADAC / プロドラッグ / 毒性発現 / 薬物動態 / 還元酵素 / ダントロレン / ニトラゼパム / アルデヒドオキシダーゼ / non-P450 / ニトロ基含有医薬品 / Non-P450 / ニトロ基含有酵素 / 医薬品毒性 / 還元反応 / 薬物代謝反応 / 紅斑性狼瘡 / シトクロムP450 / アセブトロール / ABHD10 / アシルグルクロナイド / アシルグルクロニド / 薬物誘発性肝障害 … More Except Principal Investigator 胆汁うっ滞モデルラット / 肝細胞障害モデルラット / ヘルパーT細胞 / ターゲットタンパク質 / 末梢血microRNA / バイオマーカー / ヒト肝障害患者血清 / 肝細胞障害モデル動物 / ハロタン / microRNA / 転写因子 / チトクロムP450 / マイクロRNA / 薬物誘導性肝障害 Less

Elucidation of the role of AADAC in protection against toxicity and biological homeostasis through regulation of iron concentrationPrincipal Investigator
- Principal Investigator
  
  深見達基
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Kanazawa University
Toxicological and physiological significance of AADACPrincipal Investigator
- Principal Investigator
  
  Fukami Tatsuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Kanazawa University
Elucidation of reductases related with side effects of clinical drugsPrincipal Investigator
- Principal Investigator
  
  Fukami Tatsuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University
Involvement of orphan esterases in side effects of drugs: acebutolol and ketoconazolePrincipal Investigator
- Principal Investigator
  
  Fukami Tatsuki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University
Toxicological significance of novel esterases involved in the hydrolysis of acyl-glucuronidesPrincipal Investigator
- Principal Investigator
  
  FUKAMI Tatsuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University
MicroRNAs as biomarkers for drug-induced liver injury
- Principal Investigator
  
  YOKOI Tsuyoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kanazawa University
Involvement of human orphan carboxylesterase in drug metabolism and toxicityPrincipal Investigator
- Principal Investigator
  
  FUKAMI Tatsuki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University

[Journal Article] Role of carboxylesterase and arylacetamide deacetylase in drug metabolism, physiology, and pathology2024
- Author(s)
  Mai Nagaoka, Yoshiyuki Sakai, Miki Nakajima, Tatsuki Fukami
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 223 Pages: 116128-116128
- DOI
  10.1016/j.bcp.2024.116128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06113
[Journal Article] PPARα regulates the expression of human arylacetamide deacetylase involved in drug hydrolysis and lipid metabolism2022
- Author(s)
  Morikawa Tomomi、Fukami Tatsuki、Gotoh-Saito Saki、Nakano Masataka、Nakajima Miki
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 199 Pages: 115010-115010
- DOI
  10.1016/j.bcp.2022.115010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07082
[Journal Article] Arylacetamide deacetylase knockout mice are sensitive to ketoconazole-induced hepatotoxicity and adrenal insufficiency2022
- Author(s)
  Nagaoka Mai、Fukami Tatsuki、Kisui Fumiya、Yamada Takuya、Sakai Yoshiyuki、Tashiro Kiyomichi、Ogiso Takuo、Konishi Keigo、Honda Shiori、Hirosawa Keiya、Nakano Masataka、Nakajima Miki
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 195 Pages: 114842-114842
- DOI
  10.1016/j.bcp.2021.114842
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07082
[Journal Article] Arylacetamide deacetylase as a determinant of the hydrolysis and activation of abiraterone acetate in mice and humans2021
- Author(s)
  Sakai Yoshiyuki、Fukami Tatsuki、Nagaoka Mai、Hirosawa Keiya、Ichida Hiroyuki、Sato Rei、Suzuki Kohei、Nakano Masataka、Nakajima Miki
- Journal Title
  
  Life Sciences
  
  Volume: 284 Pages: 119896-119896
- DOI
  10.1016/j.lfs.2021.119896
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07082
[Journal Article] Role of Human Arylacetamide Deacetylase (AADAC) on Hydrolysis of Eslicarbazepine Acetate and Effects of <i>AADAC</i> Genetic Polymorphisms on Hydrolase Activity2021
- Author(s)
  Hirosawa Keiya、Fukami Tatsuki、Tashiro Kiyomichi、Sakai Yoshiyuki、Kisui Fumiya、Nakano Masataka、Nakajima Miki
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 49 Issue: 4 Pages: 322-329
- DOI
  10.1124/dmd.120.000295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07082
[Journal Article] Substrate selectivity of human aldehyde oxidase 1 in reduction of nitroaromatic drugs2018
- Author(s)
  Ogiso Takuo、Fukami Tatsuki、Mishiro Kenji、Konishi Keigo、Jones Jeffrey P.、Nakajima Miki
- Journal Title
  
  Archives of Biochemistry and Biophysics
  
  Volume: 659 Pages: 85-92
- DOI
  10.1016/j.abb.2018.10.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08367
[Journal Article] Identification of enzymes responsible for dantrolene metabolism in the human liver: A clue to uncover the cause of liver injury2018
- Author(s)
  Amano Takayuki、Fukami Tatsuki、Ogiso Takuo、Hirose Daisuke、Jones Jeffrey P.、Taniguchi Tsuyoshi、Nakajima Miki
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 151 Pages: 69-78
- DOI
  10.1016/j.bcp.2018.03.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08367
[Journal Article] Identification of enzymes responsible for nitrazepam metabolism and toxicity in human2017
- Author(s)
  Konishi Keigo、Fukami Tatsuki、Gotoh Saki、Nakajima Miki
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 140 Pages: 150-160
- DOI
  10.1016/j.bcp.2017.06.114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08367
[Journal Article] A proposed mechanism of the adverse effectsof acebutolol: CES2- and CYP2C19-mediated metabolism and antinuclear antibody production2015
- Author(s)
  Kyotaka Muta, Tatsuki Fukami, Miki Nakajima
- Journal Title
  
  Biochem Pharmacology
  
  Volume: 98 Issue: 4 Pages: 659-670
- DOI
  10.1016/j.bcp.2015.09.016
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860098
[Journal Article] A comprehensive review of UDP-glucuronosyltransferase d esterases for drug development2015
- Author(s)
  Shingo Oda, Tatsuki Fukami, Tsuyoshi Yokoi, Miki Nakajima
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 30 Pages: 30-51
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26860098
[Journal Article] The emerging role of human esterases2012
- Author(s)
  Fukami, T. and Yokoi, T
- Journal Title
  
  Drug Metab. Pharmacokinet
  
  Volume: 27 Pages: 466-477
- NAID
  130004463283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590174
[Journal Article] Human a/b hydrolase domain containing 10 (ABHD10) is a responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver2012
- Author(s)
  Iwamura, A., Fukami, T., Higuchi, R., Nakajima, M., and Yokoi, T
- Journal Title
  
  J. Biol. Chem
  
  Volume: 287 Pages: 9240-9249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590174
[Journal Article] Mechanism of exacerbative effect of progesterone on drug-induced liver injury2012
- Author(s)
  Yasuyuki Toyoda, Shinya Endo, Koichi Tsuneyama, Taishi Miyashita, Azusa Yano, Tatsuki Fukami, Miki Nakajima, and Tsuyoshi Yokoi
- Journal Title
  
  Toxicol. Sci.
  
  Volume: 126 Issue: 1 Pages: 16-27
- DOI
  10.1093/toxsci/kfr326
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390174, KAKENHI-PROJECT-24390181, KAKENHI-PROJECT-24659073
[Journal Article] Plasma microRNA profiles in rat models of hepatocellular injury, cholestasis, and steatosis2012
- Author(s)
  Yu Yamaura, Miki Nakajima, Shingo Takagi, Tatsuki Fukami, Koichi Tsuneyama, and Tsuyoshi Yokoi
- Journal Title
  
  PLoS ONE
  
  Volume: 7 Issue: 2 Pages: e30250-e30250
- DOI
  10.1371/journal.pone.0030250
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390174, KAKENHI-PROJECT-24390181
[Journal Article] PPARa is regulated by miR-21 and miR-27b in human liver2011
- Author(s)
  Kida K, Nakajima M, Mohri T, Oda Y, Takagi S, Fukami T, Yokoi T
- Journal Title
  
  Pharma. Res.
  
  Volume: 28 Issue: 10 Pages: 2467-2476
- DOI
  10.1007/s11095-011-0473-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390043, KAKENHI-PROJECT-21390174
[Journal Article] Human α/β hydrolase domain containing 10 (ABHD10) is a responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver2011
- Author(s)
  Atsushi Iwamura, Tatsuki Fukami, Ryota Higuchi, Miki Nakajima, and Tsuyoshi Yokoi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 287 Issue: 12 Pages: 9240-9249
- DOI
  10.1074/jbc.m111.271288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590174
[Journal Article] In vitro evaluation of inhibitory effects of antidiabetic and antihyperlipidemic drugs on human carboxylesterase activities.2010
- Author(s)
  Tatsuki Fukami, Shiori Takahashi, Nao Nakagawa, Taiga Maruichi, Miki Nakajima, Tsuyoshi Yokoi
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 38(12) Pages: 2173-2178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790148
[Journal Article] Arylacetamide deacetylase is a determinant enzy e for the difference in hydrolase activities of phenacetin and acetaminophen.2010
- Author(s)
  Watanabe, A., Fukami, T., Takahashi, S., Kobayashi, Y., Nakagawa, N., Nakajima, M., Yokoi, T.
- Journal Title
  
  38
  
  Pages: 1532-1537
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790148
[Journal Article] MicroRNAs regulate human hepatocyte nuclear factor 4 a, modulating the expression of metabolic enzymes and cell cycle2010
- Author(s)
  Takagi S, Nakajima M, Kida K, Yamaura Y, Fukami T, Yokoi T
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 285 Issue: 7 Pages: 4415-4422
- DOI
  10.1074/jbc.m109.085431
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390043, KAKENHI-PROJECT-21390174
[Journal Article] Human CYP2E1 is regulated by miR-3782010
- Author(s)
  Mohri T, Nakajima M, Fukami T, Takamiya M, Aoki Y, Yokoi T
- Journal Title
  
  Biochem. Pharmacol.
  
  Volume: 79 Issue: 7 Pages: 1045-1052
- DOI
  10.1016/j.bcp.2009.11.015
- NAID
  120002029018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390043, KAKENHI-PROJECT-21390174
[Journal Article] Transcriptional regulation of human carboxylesterase 1Al by nuclear factor-erythroid 2 related factor 2 (Nrf2).2010
- Author(s)
  Taiga Maruichi, Tatsuki Fukami, Miki Nakajima, Tsuyoshi Yokoi
- Journal Title
  
  Biochemical Pharmacology 79・2
  
  Pages: 288-295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790148
[Journal Article] In vitro evaluation of inhibitory effects of antidiabetic and antihyperlipidemic drugs on human carboxylesterase activities.2010
- Author(s)
  Fukami, T., Takahashi, S., Nakagawa, N., Maruichi, T., Nakajima, M., Yokoi, T.
- Journal Title
  
  38
  
  Pages: 2173-2178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790148
[Journal Article] Arylacetamide deacetylase is a determinant enzyme for the difference in hydrolase activities of phenacetin and acetaminophen.2010
- Author(s)
  Akinobu Watanabe, Tatsuki Fukami, Shiori Takahashi, Yuki Kobayashi, Nao Nakagawa, Miki Nakajima, Tsuyoshi Yokoi
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 38(9) Pages: 1532-1537
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790148
[Journal Article] Interleukin-17 is involved inα-naphthylisothiocyanate-induced liver injury in mice2010
- Author(s)
  Masanori Kobayashi, Satonori Higuchi, Katsuhiko Mizuno, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima, and Tsuyoshi Yokoi
- Journal Title
  
  Toxicology
  
  Volume: 275 Issue: 1-3 Pages: 50-57
- DOI
  10.1016/j.tox.2010.05.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390174
[Journal Article] Establishment of knockdown of superoxide dismutase 2 and expression of CYP3A4 cell system to evaluate drug-induced cytotoxicity2009
- Author(s)
  Yukitaka Yoshikawa, Hiroko Hosomi, Tatsuki Fukami, Miki Nakajima, and Tsuyoshi Yokoi
- Journal Title
  
  Toxicol. In Vitro
  
  Volume: 23 Issue: 6 Pages: 1179-1187
- DOI
  10.1016/j.tiv.2009.05.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390174
[Journal Article] Transcriptional regulation of human carboxylesterase 1A1 by nuclear factor-erythroid 2 related factor 2 (Nrf2)2009
- Author(s)
  Maruichi, T., Fukami, T., Nakajima, M., Yokoi, T.
- Journal Title
  
  79
  
  Pages: 288-295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790148
[Journal Article] Human arylacetamide deacetylase is a principle enzyme in flutamide hydrolysis.2009
- Author(s)
  Watanabe, A., Fukami, T., Nakajima, M., Takamiya, M., Aoki, Y., Yokoi, T.
- Journal Title
  
  37
  
  Pages: 1513-1520
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790148
[Journal Article] Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis.2009
- Author(s)
  Akinobu Watanabe, Tatsuki Fukami, Miki Nakajima, Masataka takamiya, Yasuhiro Aoki, Tsuyoshi Yokoi
- Journal Title
  
  Drug Metabolism and Disposition 37・7
  
  Pages: 1513-1520
- NAID
  130004639493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790148
[Journal Article] Halothane-induced liver injury is mediated by interleukin-17 in mice2009
- Author(s)
  Eisuke Kobayashi, Masanori Kobayashi, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima, and Tsuyoshi Yokoi
- Journal Title
  
  Toxicol. Sci.
  
  Volume: 111 Issue: 2 Pages: 302-310
- DOI
  10.1093/toxsci/kfp165
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] アリルアセタミドデアセチラーゼは肝臓内鉄濃度を低下させることで薬物誘導性フェロトーシスに対して保護作用を示す2023
- Author(s)
  篠原颯志、深見達基、内嶋聖允、廣澤啓也、長岡茉唯、中野正隆、中島美紀
- Organizer
  第6回医薬品毒性機序研究会
- Data Source
  KAKENHI-PROJECT-23K06113
[Presentation] アリルアセタミドデアセチラーゼはフェロトーシス抑制を介して薬物性肝障害に保護的に働く2023
- Author(s)
  篠原颯志、深見達基、内嶋聖允、廣澤啓也、長岡茉唯、酒井慶之、中野正隆、中島美紀
- Organizer
  日本薬学会北陸支部第135回例会
- Data Source
  KAKENHI-PROJECT-23K06113
[Presentation] 薬物加水分解酵素AADACのPPARalphaを介した転写制御および脂質代謝に対する役割2021
- Author(s)
  森川朋美、深見達基、中野正隆、中島美紀
- Organizer
  日本薬学会北陸支部第133回例会
- Data Source
  KAKENHI-PROJECT-19K07082
[Presentation] アビラテロン酢酸エステルの薬理活性体への代謝におけるアリルアセタミドデアセチラーゼの役割2021
- Author(s)
  酒井慶之、深見達基、長岡茉唯、廣澤啓也、市田裕之、佐藤怜、鈴木康平、中野正隆、中島美紀
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K07082
[Presentation] 薬物動態および毒性の理解促進のための薬物代謝酵素基礎的知見2021
- Author(s)
  深見達基、中島美紀
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-19K07082
[Presentation] Aadacノックアウトマウスを用いたケトコナゾールによる毒性発症メカニズムの解明2021
- Author(s)
  長岡茉唯、深見達基、亀水文弥、山田卓也、酒井慶之、田代精亨、小木曽巧朗、小西慶吾、本多栞、廣澤啓也、中野正隆、中島美紀
- Organizer
  第48回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19K07082
[Presentation] Role of human AADAC on hydrolysis of eslicarbazepine acetate and effects of AADAC genetic polymorphisms on hydrolase activity2020
- Author(s)
  廣澤啓也、深見達基、田代精亨、酒井慶之、亀水文弥、中野正隆、中島美紀
- Organizer
  第35回日本薬物動態学会年会
- Data Source
  KAKENHI-PROJECT-19K07082
[Presentation] Toxicological relevance of non-P450 enzymes: hydrolases and aldehyde oxidase2019
- Author(s)
  Tatsuki Fukami
- Organizer
  12th International ISSX Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07082
[Presentation] 医薬品毒性に対するnon-P450代謝の寄与2019
- Author(s)
  深見達基
- Organizer
  第1回医薬品毒性機序研究会
- Invited
- Data Source
  KAKENHI-PROJECT-16K08367
[Presentation] 医薬品毒性および動態理解を目指したnon-CYP薬物代謝酵素の新規機能解明2018
- Author(s)
  深見達基
- Organizer
  日本薬物動態学会第33回年会/MDO第22回シンポジウム国際合同学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08367
[Presentation] 薬物代謝酵素の医薬品毒性および動態における新規機能解明2018
- Author(s)
  深見達基
- Organizer
  日本薬学会北陸支部第130回例会
- Invited
- Data Source
  KAKENHI-PROJECT-16K08367
[Presentation] ニトロ基含有薬物の還元反応を触媒するヒトアルデヒドオキシダーゼの基質認識性2018
- Author(s)
  小木曽巧朗、深見達基、三代憲司、小西慶吾、Jeffrey P. Jones、中島美紀
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K08367
[Presentation] Roles of hydrolase and aldehyde oxidase in controlling of pharmacokinetics and drug toxicity.2017
- Author(s)
  深見達基、中島美紀
- Organizer
  日本薬物動態学会第32回年会
- Invited
- Data Source
  KAKENHI-PROJECT-16K08367
[Presentation] ダントロレンの代謝酵素と肝障害の原因と考えられる反応性代謝物の生成経路と解明2017
- Author(s)
  深見達基、天野貴之、後藤紗希、廣瀬大祐、谷口剛史、中島美紀
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-16K08367
[Presentation] 副作用発症メカニズム解明の手がかりとなるニトラゼパム代謝酵素の同定2016
- Author(s)
  小西慶吾、深見達基、後藤紗希、中島美紀
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール／松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K08367
[Presentation] 肝障害および催奇形性発症機序の解明に向けたニトラゼパム代謝酵素の同定2016
- Author(s)
  小西慶吾、深見達基、後藤紗希、中島美紀
- Organizer
  日本薬学会北陸支部第128回例会
- Place of Presentation
  北陸大学／金沢
- Year and Date
  2016-11-27
- Data Source
  KAKENHI-PROJECT-16K08367
[Presentation] ヒト肝臓におけるダントロレンからのアセチルアミノダントロレン生成に関与する酵素の同定2016
- Author(s)
  天野貴之、深見達基、小西慶吾、後藤紗希、中島美紀
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール／松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K08367
[Presentation] 肝障害機序解明に向けたヒト肝臓におけるダントロレン代謝酵素の同定2016
- Author(s)
  天野貴之、深見達基、後藤紗希、中島美紀
- Organizer
  日本薬学会北陸支部第128回例会
- Place of Presentation
  北陸大学／金沢
- Year and Date
  2016-11-27
- Data Source
  KAKENHI-PROJECT-16K08367
[Presentation] ヒトにおけるプロベネシドアシルグルクロニド生成と分解を担う酵素の同定2013
- Author(s)
  伊藤祐介、深見達基、中島美紀、横井毅
- Organizer
  日本薬学会北陸支部第125回例会
- Place of Presentation
  金沢 (口頭)
- Year and Date
  2013-11-17
- Data Source
  KAKENHI-PROJECT-23590174
[Presentation] ヒト加水分解酵素がアシルグルクロニド生成に及ぼす影響2013
- Author(s)
  深見達基、伊藤祐介、岩村篤、中島美紀、横井毅
- Organizer
  平成25年度P450とUGT/SULT研究会
- Place of Presentation
  宮崎 (ポスター)
- Data Source
  KAKENHI-PROJECT-23590174
[Presentation] Recent progress in characterization of esterases in human2013
- Author(s)
  Tatsuki Fukami and Miki Nakajima
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23590174
[Presentation] ヒトにおけるプロベネシドアシルグルクロニド生成と分解を担う酵素の同定2013
- Author(s)
  伊藤祐介、深見達基、中島美紀、横井毅
- Organizer
  日本薬学会北陸支部第125回例会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23590174
[Presentation] プロベネシドからのアシルグルクロニド生成とその逆反応を担うヒト薬物代謝酵素の同定2013
- Author(s)
  伊藤祐介、深見達基、中島美紀、横井毅
- Organizer
  第40回日本毒性学会学術年会
- Place of Presentation
  千葉 (ポスター)
- Data Source
  KAKENHI-PROJECT-23590174
[Presentation] Recent progress in characterization of esterases in human2013
- Author(s)
  Tatsuki Fukami and Miki Nakajima
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  東京 (シンポジウム)
- Data Source
  KAKENHI-PROJECT-23590174
[Presentation] P450とnon-P450酵素が誘発する副作用：メトヘモグロビン血症と肝障害2012
- Author(s)
  中島美紀、深見達基、横井毅
- Organizer
  第27回日本薬物動態学会
- Place of Presentation
  東京　タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23590174
[Presentation] Involvement of interleukin-17 in drug-induced liver injury in mice2010
- Author(s)
  Eisuke Kobayashi, Masanori Kobayashi, Tatsuki Fukami, Miki Nakajima, and Tsuyoshi Yokoi
- Organizer
  SOT 49th Annual Meeting
- Place of Presentation
  Hilton Salt Lake City Center Hotel, Salt Lake City-USA
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] Arylacetamide deacetylase is a determinant enzyme for the difference in hydrolase activities of phenacetin and acetaminophen.2010
- Author(s)
  Fukami.T, Watanabe.A, Takahashi.S, Nakagawa.N, Nakajima.M, Yokoi.T.
- Organizer
  9^<th> International ISSX Meeting
- Place of Presentation
  Istanbul Convention and Exhibition Centre (Turkey)
- Data Source
  KAKENHI-PROJECT-21790148
[Presentation] ヒトカルボキシルエステラーゼ1AのNrf2による転写調節2010
- Author(s)
  丸一泰雅, 深見達基, 中島美紀, 横井毅
- Organizer
  日本薬物動態学会第24回年会
- Place of Presentation
  国立京都国際会館(京都府)
- Data Source
  KAKENHI-PROJECT-21790148
[Presentation] 糖尿病および高脂血漿治療薬のヒトカルボキシルエステラーゼ酵素活性に対する阻害効果2010
- Author(s)
  深見達基, 高橋志織, 中川尚, 中島美紀, 横井毅
- Organizer
  日本薬物動態学会第24回年会
- Place of Presentation
  国立京都国際会館(京都府)
- Data Source
  KAKENHI-PROJECT-21790148
[Presentation] ヒトアリルアセタミドデアセチラーゼはリファマイシン系薬物の加水分解を担う主代謝酵素である2010
- Author(s)
  中島彰紀、深見達基、渡邊旭廷、小林祐喜、中島美紀、横井毅
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックシティ(埼玉県)
- Data Source
  KAKENHI-PROJECT-21790148
[Presentation] マウス、ラット及びヒトにおけるアリルアセタミドデアセチラーゼの発現臓器及び酵素活性の種差に関する検討2010
- Author(s)
  小林祐喜, 深見達基, 中島彰紀, 渡邊旭延, 中島美紀, 横井毅
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックシティ(埼玉県)
- Data Source
  KAKENHI-PROJECT-21790148
[Presentation] フェナセチンおよびアセトアミノフェンによる毒性の差異に対するヒトアリルアセタミドデアセチラーゼの重要性2010
- Author(s)
  深見達基、渡邊旭延、高橋志織、小林祐喜、中川尚、中島美紀、横井毅
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックシティ(埼玉県)
- Data Source
  KAKENHI-PROJECT-21790148
[Presentation] Human PPARa is regulated by miR-212010
- Author(s)
  Katsuhiko Kida, Miki Nakajima, Takuya Mohri, Yuki Oda, Shingo Tagagi, Tatsuki Fukami, and Tsuyoshi Yokoi
- Organizer
  9th International ISSX Meeting
- Place of Presentation
  Istanbul Conventin & Exihition Center, Istanbul-Tukey
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] Mechanism of hepatoprotective effect of tamoxifen against drug-induced liver injury2010
- Author(s)
  Yukitaka Yoshikawa, Yasuyuki Toyoda, Satonori Higuchi, Tohru Tsuku, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima, and Tsuyoshi Yokoi
- Organizer
  9th International ISSX Meeting
- Place of Presentation
  Istanbul Conventin & Exihition Center, Istanbul-Tukey
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] マウス、ラット及びヒトにおけるアリルアセタミドデアセチラーゼの発現臓器及び酵素活性の種差に関する検討2010
- Author(s)
  小林祐喜、深見達基、中島彰紀、渡邊旭延、中島美紀、横井毅
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックシティ(埼玉県)
- Data Source
  KAKENHI-PROJECT-21790148
[Presentation] ヒトアリルアセタミドデアセチラーゼはリファマイシン系薬物の加水分解を担う主代謝酵素である2010
- Author(s)
  中島彰紀, 深見達基, 渡邊旭延, 小林祐喜, 中島美紀, 横井毅
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックシティ(埼玉県)
- Data Source
  KAKENHI-PROJECT-21790148
[Presentation] フェナセチンおよびアセトアミノフェンによる毒性の差異に対するヒトアリルアセタミドデアセチラーゼの重要性2010
- Author(s)
  深見達基, 渡邊旭延, 高橋志織, 小林祐喜, 中川尚, 中島美紀, 横井毅
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックシティ(埼玉県)
- Data Source
  KAKENHI-PROJECT-21790148
[Presentation] ヒトアリルアセタミドデアセチラーゼのフルタミド加水分解に対する関与2010
- Author(s)
  渡邊旭延, 深見達基, 中島美紀, 高宮正隆, 青木康博, 横井毅
- Organizer
  日本薬物動態学会第24回年会
- Place of Presentation
  国立京都国際会館(京都府)
- Data Source
  KAKENHI-PROJECT-21790148
[Presentation] Arylacetamide deacetylase is a determinant enzyme for the difference in hydrolase activities of phenacetin and acetaminophen.2010
- Author(s)
  Tatsuki Fukami, Akinobu Watanabe, Shiori Takahashi, Nao Nakagawa, Miki Nakajima, Tsuyoshi Yokoi
- Organizer
  9th International ISSX Meeting
- Place of Presentation
  CONGRESS CENTER (Turkey)
- Data Source
  KAKENHI-PROJECT-21790148
[Presentation] ヒトアリルアセタミドデアセチラーゼのフルタミド加水分解に対する関与2009
- Author(s)
  渡邊旭延、深見達基、中島美紀、高宮正隆、青木康博、横井毅
- Organizer
  第24回日本薬物動態学会年会
- Place of Presentation
  国立京都国際会館(京都府)
- Data Source
  KAKENHI-PROJECT-21790148
[Presentation] Human hepatocyte nuclear factor 4a is regulated bymiR-242009
- Author(s)
  Shingo Takagi, Miki Nakajima, Katsuhiko Kida, Tatsuki Fukami, and Tsuyoshi Yokoi
- Organizer
  3rd Asia Pacific ISSX Meeting
- Place of Presentation
  The Imperial Queen's Park Hotel, Bangkok, Thailand
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] Halothane-induced liver injury is mediated by interleukin-17 in mice2009
- Author(s)
  Tsuyoshi Yokoi, Eisuke Kobayashi, Tatsuki Fukami, and Miki Nakajima
- Organizer
  16^<th> North American Regional ISSX Meeting
- Place of Presentation
  Baltimore Marriott Waterfront, Baltimore, USA
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] 糖尿病および高脂血漿治療薬のヒトカルボキシルエステラーゼ酵素活性に対する阻害効果2009
- Author(s)
  深見達基、高橋志織、中川尚、中島美紀、横井毅
- Organizer
  第24回日本薬物動態学会年会
- Place of Presentation
  国立京都国際会館(京都府)
- Data Source
  KAKENHI-PROJECT-21790148
[Presentation] ヒトカルボキシルエステラーゼ1AのNrf2による転写調節2009
- Author(s)
  丸一泰雅、深見達基、中島美紀、横井毅
- Organizer
  第24回日本薬物動態学会年会
- Place of Presentation
  国立京都国際会館(京都府)
- Data Source
  KAKENHI-PROJECT-21790148
[Presentation] MiR-24 regulates human HNF4a expression2009
- Author(s)
  Shingo Takagi, Miki Nakajima, Katsuhiko Kida, Tatsuki Fukami, and Tsuyoshi Yokoi
- Organizer
  16th International Conference on Cytochrome P450
- Place of Presentation
  Bankoku Shinryokan, Nago, Japan
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] MicroRNA regulates the expression of human CYP2E12009
- Author(s)
  Takuya Mohri, Miki Nakajima, Tatsuki Fukami, and Tsuyoshi Yokoi
- Organizer
  16th International Conference on Cytochrome P450
- Place of Presentation
  Bankoku Shinryokan, Nago, Japan
- Data Source
  KAKENHI-PROJECT-21390174
[Presentation] β遮断薬アセブトロールの毒性発現における薬物代謝の役割
- Author(s)
  牟田恭尭、深見達基、中島美紀
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸
- Year and Date
  2014-07-02 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-26860098
[Presentation] Comparison of substrate specificity between human arylacetamide deacetylase and carboxylesterases
- Author(s)
  Tatsuki Fukami, Motoki Kariya, Takaya Kurokawa, Azumi Iida, and Miki Nakajima
- Organizer
  19th North American International Society for the Study of Xenobiotics29th Japanese Society for the Study of Xenobiotics Meeting
- Place of Presentation
  San Francisco, CA
- Year and Date
  2014-10-18 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-26860098
[Presentation] 医薬品副作用に関与する新規加水分解酵素の役割
- Author(s)
  深見達基
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸
- Year and Date
  2014-07-02 – 2014-07-04
- Invited
- Data Source
  KAKENHI-PROJECT-26860098
[Presentation] Screening of specific inhibitors for human carboxylesterases or arylacetamide deacetylase
- Author(s)
  Tatsuki Fukami, Mai Shimizu, Tsuyoshi Yokoi, and Miki Nakajima
- Organizer
  20th International Symposium on Microsomes and Drug Oxidations
- Place of Presentation
  Stuttgart, Germany
- Year and Date
  2014-05-18 – 2014-05-22
- Data Source
  KAKENHI-PROJECT-26860098

1. YOKOI Tsuyoshi (70135226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
2. 中嶋美紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

fukami tatsuki 深見 達基

深見 達基 フカミ タツキ

FUKAMI Tatsuki 深見 達基

Research Projects

Research Products

Co-Researchers

Elucidation of the role of AADAC in protection against toxicity and biological homeostasis through regulation of iron concentrationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Toxicological and physiological significance of AADACPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of reductases related with side effects of clinical drugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of orphan esterases in side effects of drugs: acebutolol and ketoconazolePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Toxicological significance of novel esterases involved in the hydrolysis of acyl-glucuronidesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MicroRNAs as biomarkers for drug-induced liver injury

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of human orphan carboxylesterase in drug metabolism and toxicityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Role of carboxylesterase and arylacetamide deacetylase in drug metabolism, physiology, and pathology2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PPARα regulates the expression of human arylacetamide deacetylase involved in drug hydrolysis and lipid metabolism2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Arylacetamide deacetylase knockout mice are sensitive to ketoconazole-induced hepatotoxicity and adrenal insufficiency2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Arylacetamide deacetylase as a determinant of the hydrolysis and activation of abiraterone acetate in mice and humans2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of Human Arylacetamide Deacetylase (AADAC) on Hydrolysis of Eslicarbazepine Acetate and Effects of <i>AADAC</i> Genetic Polymorphisms on Hydrolase Activity2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Substrate selectivity of human aldehyde oxidase 1 in reduction of nitroaromatic drugs2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of enzymes responsible for dantrolene metabolism in the human liver: A clue to uncover the cause of liver injury2018

Author(s)

fukami tatsuki 深見達基

深見達基フカミタツキ

FUKAMI Tatsuki 深見達基