Hasegawa Junya 長谷川純矢

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HASEGAWA Junya 長谷川純矢

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Researcher Number	00533788
Other IDs	https://orcid.org/0000-0003-1216-7468
Affiliation (Current)	2025: 東京科学大学, その他の部局等, 非常勤講師 2025: 北里大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2024: 北里大学, 薬学部, 講師 2019 – 2023: 東京医科歯科大学, 難治疾患研究所, 助教 2015: 大阪大学, 大学院生命機能研究科, 助教 2012 – 2015: 大阪大学, 生命機能研究科, 助教
Review Section/Research Field	Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Structural biochemistry / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Basic Section 43030:Functional biochemistry-related Except Principal Investigator Functional biochemistry
Keywords	Principal Investigator 質量分析 / リン脂質 / イノシトールリン脂質 / 老化 / 脂肪酸 / Gタンパク質共役受容体 / すい臓がん / GPCR / リゾリン脂質 / リソソーム … More / 脂質 / オートファジー / EGF / Multivesicular body / SH3ドメイン / エンドサイトーシス … More Except Principal Investigator F-Barドメイン / 脂質結合蛋白質 / PIP3 ホスファターゼ / 膜変形 / インスリン　シグナル / PI4P / Sac1 / SKIP / インスリン / ホスホイノシタイド　５－ホスファターゼ / 脂質結合タンパク質 / 膜形成 / がん細胞転移 / インスリンシグナル / 膜の形 / ホスホイノシタイド Less

リン脂質から迫る老化誘導マシナリーの解明Principal Investigator
- Principal Investigator
  
  長谷川純矢
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Kitasato University
Comprehensive search for novel phospholipids and elucidation of their functionsPrincipal Investigator
- Principal Investigator
  
  Hasegawa Junya
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Tokyo Medical and Dental University
A study of novel lysophospholipids and exploration of their targetsPrincipal Investigator
- Principal Investigator
  
  Hasegawa Junya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Tokyo Medical and Dental University
Identification of novel molecules on lysosomal membrane using our unique techniquePrincipal Investigator
- Principal Investigator
  
  Hasegawa Junya
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Tokyo Medical and Dental University
The development of method for the isolation of autophagosomesPrincipal Investigator
- Principal Investigator
  
  Hasegawa Junya
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University
Analysis of the role of SH3YL1 in the morphology of plasma membrane and endocytosis machineryPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Junya
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University
Regulation of cell dynamism by phosphoinositides
- Principal Investigator
  
  Takenawa Tadaomi
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kobe University

All 2023 2022 2021 2019 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book Other

[Book] Thr Lipid2021
- Author(s)
  長谷川　純矢
- Total Pages
  7
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-20H03206
[Book] 哺乳動物個体レベルでのオートファジーの意義と疾患とのかかわり, ファルマシア49 (6)2013
- Author(s)
  長谷川純矢、吉森保
- Data Source
  KAKENHI-PROJECT-24770098
[Journal Article] Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity.2023
- Author(s)
  Tran DM, Yoshioka N, Bizen N, Mori-Ochiai Y, Yano M, Yanai S, Hasegawa J, Miyashita S, Hoshino M, Sasaki J, Sasaki T, Takebayashi H
- Journal Title
  
  Dis Model Mech
  
  Volume: 16 Issue: 7 Pages: 192-206
- DOI
  10.1242/dmm.050169
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15912, KAKENHI-PROJECT-23K14295, KAKENHI-PROJECT-23K06300, KAKENHI-PROJECT-23K06317, KAKENHI-PROJECT-22K19287, KAKENHI-PROJECT-19H03543, KAKENHI-PROJECT-21H02652, KAKENHI-PUBLICLY-22H05589, KAKENHI-PROJECT-20H00485, KAKENHI-PROJECT-21H02680, KAKENHI-PROJECT-23K23993, KAKENHI-PROJECT-23K27319
[Journal Article] Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration2023
- Author(s)
  Benyair Ron、Panapakkam Giridharan Sai Srinivas、Rivero-R?os Pilar、Hasegawa Junya、Bristow Emily、Eskelinen Eeva-Liisa、Shmueli Merav D、Fishbain-Yoskovitz Vered、Merbl Yifat、Sharkey Lisa M、Paulson Henry L.、Hanson Phyllis I、Patnaik Samarjit、Al-Ramahi Ismael、Botas Juan、Marugan Juan、Weisman Lois S.
- Journal Title
  
  Autophagy Reports
  
  Volume: 2 Issue: 1 Pages: 2166722-2166722
- DOI
  10.1080/27694127.2023.2166722
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03206, KAKENHI-PROJECT-22K19287
[Journal Article] A mass spectrometric method for in-depth profiling of phosphoinositide regioisomers and their diseaseassociated regulation.2022
- Author(s)
  Morioka S, Nakanishi H, Yamamoto T, Hasegawa J, Tokuda E, Hikita T, Sakihara T, Kugii Y, Oneyama C, Yamazaki M, Suzuki A, Sasaki J, Sasaki T.
- Journal Title
  
  Nature Communications
  
  Volume: 13(1) Issue: 1 Pages: 83-83
- DOI
  10.1038/s41467-021-27648-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H04905, KAKENHI-PUBLICLY-20H04920, KAKENHI-PROJECT-20H03456, KAKENHI-PROJECT-21H02680, KAKENHI-PROJECT-20J40228, KAKENHI-PROJECT-21K19329, KAKENHI-PROJECT-22K19287, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H04806, KAKENHI-PROJECT-20H03206, KAKENHI-PROJECT-20K20661
[Journal Article] Plasma membrane phosphatidylinositol (4,5)-bisphosphate is critical for determination of epithelial characteristics2022
- Author(s)
  Kaori Kanemaru, Makoto Shimozawa, Manabu Kitamata, Rikuto Furuishi, Hinako Kayano, Yui Sukawa, Yuuki Chiba, Takatsugu Fukuyama, Junya Hasegawa, Hiroki Nakanishi, Takuma Kishimoto, Kazuya Tsujita, Kazuma Tanaka, Toshiki Itoh, Junko Sasaki, Takehiko Sasaki, Kiyoko Fukami, Yoshikazu Nakamura
- Journal Title
  
  Nature Communications
  
  Volume: － Issue: 1 Pages: 2347-2347
- DOI
  10.1038/s41467-022-30061-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02575, KAKENHI-PROJECT-21K15109, KAKENHI-PROJECT-19K06536, KAKENHI-PROJECT-22K19287, KAKENHI-PROJECT-20H03206, KAKENHI-PROJECT-21H02680, KAKENHI-PROJECT-23K23838
[Journal Article] PP2A-dependent TFEB activation is blocked by PIKfyve-induced mTORC1 activity2022
- Author(s)
  Hasegawa Junya、Tokuda Emi、Yao Yao、Sasaki Takehiko、Inoki Ken、Weisman Lois S.
- Journal Title
  
  Molecular Biology of the Cell
  
  Volume: 33 Issue: 3
- DOI
  10.1091/mbc.e21-06-0309
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20J40228, KAKENHI-PROJECT-21K19329, KAKENHI-PROJECT-22K19287, KAKENHI-PROJECT-20H03206
[Journal Article] A Role of Phosphatidylserine in the Function of Recycling Endosomes2021
- Author(s)
  Hasegawa Junya、Uchida Yasunori、Mukai Kojiro、Lee Shoken、Matsudaira Tatsuyuki、Taguchi Tomohiko
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 9 Pages: 783857-783857
- DOI
  10.3389/fcell.2021.783857
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H05307, KAKENHI-PROJECT-20H03202, KAKENHI-PROJECT-20H03206, KAKENHI-PROJECT-21K06153, KAKENHI-PROJECT-17H06164, KAKENHI-PLANNED-17H06418
[Journal Article] SH3YL1 cooperates with ESCRT-I in the sorting and degradation of the EGF receptor2019
- Author(s)
  Hasegawa Junya、Jebri Imen、Yamamoto Hikaru、Tsujita Kazuya、Tokuda Emi、Shibata Hideki、Maki Masatoshi、Itoh Toshiki
- Journal Title
  
  Journal of Cell Science
  
  Volume: 132 Issue: 19 Pages: 229179-229179
- DOI
  10.1242/jcs.229179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06541, KAKENHI-PROJECT-19K06638, KAKENHI-PROJECT-19K22275, KAKENHI-PROJECT-19K22381, KAKENHI-PROJECT-16H04785
[Journal Article] Selective autophagy: Lysophagy2015
- Author(s)
  Hasegawa J, Maejima I, Iwamoto R, Yoshimori T
- Journal Title
  
  Methods
  
  Volume: 75 Pages: 128-132
- DOI
  10.1016/j.ymeth.2014.12.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26650019, KAKENHI-ORGANIZER-25111001
[Journal Article] Phosphatidylinositol 4-phosphate in the Golgi apparatus regulates cell-cell adhesion and invasive cell migration in human breast cancer2014
- Author(s)
  Tokuda E, Itoh T, Hasegawa J, Ijuin T, Takeuchi Y, Irino Y, Fukumoto M, Takenawa T.
- Journal Title
  
  Cancer Research
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24770098
[Journal Article] Phosphatidylinositol 4-phosphate in the Golgi apparatus regulates cell-cell adhesion, cell migration and invasion in human breast cancer2014
- Author(s)
  Tokuda E., Itoh T., Hasegawa J., Ijuin T., Takeuchi Y., Irino, Y., Fukumoto M., and Takenawa T.
- Journal Title
  
  Cancer Res. 74, 3054-3066 (2014)
  
  Volume: 74 Pages: 3054-3066
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23227005
[Journal Article] Antagonistic regulation of F-BAR protein assemblies controls actin polymerization during podosome formation2014
- Author(s)
  Tsujita K, Kondo A, Kurisu S, Hasegawa J, Itoh T, Takenawa T
- Journal Title
  
  J Cell Sci
  
  Volume: 126 Pages: 2267-2278
- Data Source
  KAKENHI-PROJECT-24770098
[Journal Article] Phosphatidylinositol 4-phosphate in the Golgi apparatus regulates cell-cell adhesion, and invasive cell migration in human breast cancer2014
- Author(s)
  Tokuda E., Itoh T., Hasegawa J., Ijuin T., Takeuchi Y., Irino, Y., Fukumoto M., and Takenawa T.
- Journal Title
  
  Cancer Res.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23227005
[Journal Article] Phosphatidylinositol 4-phosphate in the Golgi apparatus regulates cell-cell adhesion and invasive cell migration in human breast cancer2014
- Author(s)
  Tokuda E, Itoh T, Hasegawa J, Ijuin T, Takeuchi Y, Irino Y, Fukumoto M, Takenawa T
- Journal Title
  
  Cancer Res
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-24770098
[Journal Article] Mechanistic insights into the regulation of circular dorsal ruffle formation.2013
- Author(s)
  Itoh T, Hasegawa J.
- Journal Title
  
  J Biochem.
  
  Volume: 153 Issue: 1 Pages: 21-29
- DOI
  10.1093/jb/mvs138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570216, KAKENHI-PROJECT-24770098, KAKENHI-PUBLICLY-24113715
[Journal Article] Antagonistic regulation of F-BAR protein assemblies controls actin polymerization during podosome formation.2013
- Author(s)
  Tsujita K, Kondo A, Kurisu S, Hasegawa J, Itoh T, Takenawa T.
- Journal Title
  
  J. Cell Sci.
  
  Volume: 126 Pages: 2267-2278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23227005
[Journal Article] Antagonistic regulation of F-BAR protein assemblies controls actin polymerization during podosome formation.2013
- Author(s)
  Tsujita K, Kondo A, Kurisu S, Hasegawa J, Itoh T, Takenawa T.
- Journal Title
  
  J Cell Sci.
  
  Volume: 126 Pages: 2267-2278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24770098
[Journal Article] Mechanistic insights into the regulation of circular dorsal ruffle formation2013
- Author(s)
  Itoh T, Hasegawa J
- Journal Title
  
  J Biochem
  
  Volume: 153 Pages: 21-29
- NAID
  40019546440
- Data Source
  KAKENHI-PROJECT-24770098
[Journal Article] ARAP1 regulates the ring size of circular dorsal ruffles through Arf1 and Arf52012
- Author(s)
  Hasegawa J
- Journal Title
  
  Mol. Biol. Cell
  
  Volume: 23 Issue: 13 Pages: 2481-2489
- DOI
  10.1091/mbc.e12-01-0017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23227005, KAKENHI-PROJECT-23770228, KAKENHI-PROJECT-24570216, KAKENHI-PROJECT-24770098, KAKENHI-PUBLICLY-24113715
[Journal Article] Qu antification and visualization of phosphoinositides by quantum dot-labeled specific binding-domain probes2012
- Author(s)
  Irino Y, Tokuda E, Hasegawa J, Itoh T, Takenawa T
- Journal Title
  
  J Lipid Res
  
  Volume: 53 Pages: 810-819
- Data Source
  KAKENHI-PROJECT-24770098
[Journal Article] Quantification and visualization of phosphoinositides by quantum dot-labeled specific binding-domain probes2012
- Author(s)
  Irino Y, Tokuda E, Hasegawa J, Itoh T, Takenawa T
- Journal Title
  
  J.Lipid.Res.
  
  Volume: (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23227005
[Journal Article] A RAP1 regulates the ring size of circular dorsal ruffles through Arf1 and Arf52012
- Author(s)
  Hasegawa J, Tsujita K, Takenawa T, Itoh T
- Journal Title
  
  Mol Biol Cell
  
  Volume: 23 Pages: 2481-2489
- Data Source
  KAKENHI-PROJECT-24770098
[Journal Article] SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain2011
- Author(s)
  Hasegawa J, Tbkuda E, Tenno T, Isujita K, Sawai H, Hiroaki H, Takenawa T, Itoh T
- Journal Title
  
  J.Cell Biol.
  
  Volume: 193 Pages: 901-916
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23227005
[Presentation] イノシトールリン脂質が制御する老化メカニズムの解明2023
- Author(s)
  長谷川純矢、佐々木純子、佐々木雄彦
- Organizer
  第65回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-22K19287
[Presentation] A new insights into the roles of phosphoinositides in lysosomal function2021
- Author(s)
  Junya Hasegawa, Lois S. Weisman, Junko Sasaki, Takehiko Sasaki
- Organizer
  第44回日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03206
[Presentation] Inositol polyphosphate-5-phosphatase INPP5E regulates autophagy in neural cells2014
- Author(s)
  Hasegawa Junya
- Organizer
  Keystone Symposia
- Place of Presentation
  Austin, Texas, USA
- Data Source
  KAKENHI-PROJECT-24770098
[Presentation] Inositol polyphosphate-5-phosphatase INPP5E regulates autophagy in neural cells
- Author(s)
  Junya Hasegawa, Tamotsu Yoshimori
- Organizer
  Keystone Symposia (Autophagy: Fundamentals to Disease)
- Place of Presentation
  Hyatt Regency Austin, Austin, Texas, USA
- Year and Date
  2014-05-23 – 2014-05-28
- Data Source
  KAKENHI-PROJECT-26650019
[Presentation] Inositol polyphosphate-5-phosphatase INPP5E regulates autophagy in neural cells
- Author(s)
  Junya Hasegawa, Tamotsu Yoshimori
- Organizer
  第６６回日本細胞生物学会大会
- Place of Presentation
  奈良県新公会堂
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-26650019
[]

1. Takenawa Tadaomi (40101315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. ITOH Toshiki (30313092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
3. IJUIN Takeshi (00361626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. TSUJITA Kazuya (10457054)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. TOKUDA Emi (70621960)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. IRINO Yasuhiro (10415565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 井上飛鳥 (50525813)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 吉岡望

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 鈴木聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 中村由和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 向井康治朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hasegawa Junya 長谷川 純矢

HASEGAWA Junya 長谷川 純矢

Research Projects

Research Products

Co-Researchers

リン脂質から迫る老化誘導マシナリーの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive search for novel phospholipids and elucidation of their functionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A study of novel lysophospholipids and exploration of their targetsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of novel molecules on lysosomal membrane using our unique techniquePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The development of method for the isolation of autophagosomesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the role of SH3YL1 in the morphology of plasma membrane and endocytosis machineryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of cell dynamism by phosphoinositides

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Thr Lipid2021

Author(s)

Total Pages

Publisher

Data Source

[Book] 哺乳動物個体レベルでのオートファジーの意義と疾患とのかかわり, ファルマシア49 (6)2013

Author(s)

Data Source

[Journal Article] Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A mass spectrometric method for in-depth profiling of phosphoinositide regioisomers and their diseaseassociated regulation.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Plasma membrane phosphatidylinositol (4,5)-bisphosphate is critical for determination of epithelial characteristics2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PP2A-dependent TFEB activation is blocked by PIKfyve-induced mTORC1 activity2022

Author(s)

Journal Title

DOI

Data Source

Hasegawa Junya 長谷川純矢

HASEGAWA Junya 長谷川純矢