KUMAI Takumi 熊井琢美

Researcher Number	00596306
Affiliation (Current) *help	2018 : 旭川医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2016 – 2018 : 旭川医科大学, 医学部, 助教 2012 – 2014 : 旭川医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Otorhinolaryngology Except Principal Investigator Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related
Keywords	Principal Investigator ペプチドワクチン / 腫瘍免疫 / 頭頸部癌 / ヘルパーT細胞 / 分子標的薬 / c-Met / EGFR阻害薬 / 腫瘍抗原 / 国際情報交換 / EGFR / アジュバント / ペプチドワクチン療法 / HLA … More Except Principal Investigator … More

鼻性NK/T細胞リンパ腫における免疫抑制機構の解明と新規免疫療法の開発Ongoing
- Principal Investigator
  
  原渕保明
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Asahikawa Medical College
頭頸部癌に対する分子標的薬を中心としたアジュバントによる免疫療法の開発Principal InvestigatorOngoing
- Principal Investigator
  
  熊井琢美
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Asahikawa Medical College
A foundational study for targeted therapy against EB virus and tumor growth factor in nasal NK/T-cell lymphoma
- Principal Investigator
  
  HARABUCHI Yasuaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Asahikawa Medical College
HER family targeted immunotherapy against head and neck squamous cancerPrincipal Investigator
- Principal Investigator
  
  KUMAI Takumi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Asahikawa Medical College

All 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Peptide vaccines in cancer ― old concept revisited2017
- Author(s)
  Takumi Kumai, Hiroya Kobayashi, Yasuaki Harabuchi and Esteban Celis
- Journal Title
  
  Current opinion in immunology
  
  Volume : 45 Pages : 1-7
- DOI
  10.1016/j.coi.2016.11.001
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20223
[Journal Article] Optimization of Peptide Vaccines to Induce Robust Antitumor CD4 T-cell Responses2017
- Author(s)
  Shirota H, Klinman DM, Ito SE, Ito H, Kubo M, Ishioka C
- Journal Title
  
  Cancer Immunol Res
  
  Volume : 5(1) Pages : 61-71
- Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01162, KAKENHI-PUBLICLY-15H01267, KAKENHI-PROJECT-16K20223, KAKENHI-PROJECT-16H02474, KAKENHI-PROJECT-16H04708, KAKENHI-PROJECT-16K07162, KAKENHI-PROJECT-16K15551, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-24591901, KAKENHI-PROJECT-26460188, KAKENHI-PLANNED-24108006, KAKENHI-PROJECT-24591880, KAKENHI-PROJECT-24659592
[Journal Article] Novel targets for natural killer/T-cell lymphoma immunotherapy.2016
- Author(s)
  Kumai T, Kobayashi H, Harabuchi Y.
- Journal Title
  
  Immunotherapy
  
  Volume : 8 Issue : 1 Pages : 45-55
- DOI
  10.2217/imt.15.103
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460430, KAKENHI-PROJECT-24791735, KAKENHI-PROJECT-15H04986
[Journal Article] Assessment of the change in cetuximab induced ADCC activity of NK cells by steroid2016
- Author(s)
  Kumai T, Oikawa K, Aoki N, Kimura S, Harabuchi Y, Kobayashi H.
- Journal Title
  
  Head & Neck
  
  Volume : 38(3) Pages : 410-6
- DOI
  10.1002/hed.23906
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460430, KAKENHI-PROJECT-24791735
[Journal Article] Targeting HER-3 to elicit antitumor helper T cells against head and neck squamous cell carcinoma.2015
- Author(s)
  Kumai T, Ohkuri T, Nagato T, Matsuda Y, Oikawa K, Aoki N, Kimura S, Celis E, Harabuchi Y, Kobayashi H.
- Journal Title
  
  Scientific Reports
  
  Volume : 5 Pages : 16280-16280
- DOI
  10.1038/srep16280
- Language
  English
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460430, KAKENHI-PROJECT-24791735
[Journal Article] CCL17 and CCL22/CCR4 signaling is a strong candidate for novel targeted therapy against nasal natural killer/T-cell lymphoma2015
- Author(s)
  Takumi Kumai, Toshihiro Nagato, Hiroya Kobayashi, Yuki Komabayashi, Seigo Ueda, Kan Kishibe, Takayuki Ohkuri, Miki Takahara, Esteban Celis, Yasuaki Harabuchi
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume : 64 Issue : 6 Pages : 697-705
- DOI
  10.1007/s00262-015-1675-7
- Language
  English
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390385, KAKENHI-PROJECT-15H04986
[Journal Article] ヘルパーT細胞と免疫アジュバントを用いた頭頸部癌免疫治療の開発2014
- Author(s)
  熊井　琢美、長門　利純、高原　幹、小林　博也、原渕　保明
- Journal Title
  
  耳鼻咽喉科免疫アレルギー
  
  Volume : 32 Issue : 3 Pages : 185-190
- DOI
  10.5648/jjiao.32.185
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791735
[Journal Article] EGFR inhibitors augment antitumour helper T-cell responses of HER family-specific immunotherapy2013
- Author(s)
  T Kumai, Y Matsuda, K Oikawa, N Aoki, S Kimura, Y Harabuchi, E Celis and H Kobayashi
- Journal Title
  
  BRITISH JOURNAL OF CANCER
  
  Volume : 109 Issue : 6 Pages : 2155-2166
- DOI
  10.1038/bjc.2013.577
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791735, KAKENHI-PROJECT-25460430
[Presentation] ヘルパーペプチドワクチンの実用化に向けたアジュバントの開発2018
- Author(s)
  熊井琢美//大原賢三//野崎　結//長門利純//林達哉//小林博也//原渕保明
- Organizer
  日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-16K20223
[Presentation] Optimization of peptide vaccines to induce robust antitumor CD4 T-cell responses2018
- Author(s)
  Kumai T.//Sultan, H.//Kobayashi, H.//Harabuchi, Y.//Celis, E.
- Organizer
  American Association for Cancer Research Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20223
[Presentation] The identification of nasal NK/T-cell lymphoma-associated antigens for helper T cell-based immunotherapy2017
- Author(s)
  Kumai, T.//Nagato, T,//Takahara, M.//Katada, A.//,Hayashi, T.//Harabuchi, Y.
- Organizer
  53rd Korean Rhinologic Society Annual Congress
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-16K20223
[Presentation] Antitumor responses by HER-3-reactive CD4 helper T cells combined with HER inhibitor in vitro2017
- Author(s)
  Kumai, T.//Hayashi, T.//Kobayashi, H.//Harabuchi, Y.
- Organizer
  The International Federation of ORL Societies (IFOS) 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20223
[Presentation] EBウイルス陽性鼻性NK/T細胞リンパ腫にたいするペプチドワクチン療法の開発2017
- Author(s)
  熊井琢美//長門利純//林　達哉/小林博也//原渕保明
- Organizer
  日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-16K20223
[Presentation] The identification of nasal NK/T-cell lymphoma-associated antigens for helper T cell-based immunotherapy2017
- Author(s)
  Takumi Kumai, Toshihiro Nagato, Miki Takahara, Akihiro Katada, Tatsuya Hayashi, Yasuaki Harabuchi
- Organizer
  53rd Korean Rhinologic Society Annual Congress
- Place of Presentation
  ソウル、韓国
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-16K20223
[Presentation] EBウイルス陽性鼻性NK/T細胞リンパ腫にたいするペプチドワクチン療法の開発2017
- Author(s)
  熊井琢美, 長門利純, 林達哉, 小林博也, 原渕保明
- Organizer
  第65回日本ウイルス学会
- Place of Presentation
  大阪
- Year and Date
  2017-10-25
- Data Source
  KAKENHI-PROJECT-24791735
[Presentation] The identification of nasal NK/T-cell lymphoma-associated antigens for helper T cell-based immunotherapy2017
- Author(s)
  Takumi Kumai, Toshihiro Nagato, Miki Takahara, Akihiro Katada, Tatsuya Hayashi, Yasuaki Harabuchi
- Organizer
  53rd Korean Rhinologic Society Annual Congress
- Place of Presentation
  ソウル(韓国)
- Year and Date
  2017-03-12
- Data Source
  KAKENHI-PROJECT-24791735
[Presentation] Antitumor responses by HER-3-reactive CD4 helper T cells combined with HER inhibitor in vitro2017
- Author(s)
  Takumi Kumai, Tatsuya Hayashi, Hiroya Kobayashi, Yasuaki Harabuchi
- Organizer
  The International Federation of ORL Societies (IFOS) 2017
- Place of Presentation
  パリ(フランス)
- Year and Date
  2017-06-24
- Data Source
  KAKENHI-PROJECT-24791735
[Presentation] HER-3標的ヘルパーCD4 T細胞による抗腫瘍効果と HER 阻害薬併用による相乗効果の検討2016
- Author(s)
  熊井琢美, 大原賢三, 平田結, 大栗敬幸, 小坂朱, 長門利純, 石橋佳, 及川賢輔, 原渕保明, 小林博也
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-24791735
[Presentation] HER-3由来CD4エピトープの同定およびHER阻害薬との併用について2016
- Author(s)
  熊井琢美, 石橋佳, 大栗敬幸, 及川賢輔, 青木直子, 原渕保明, 小林博也
- Organizer
  第105回日本病理学会学術総会
- Place of Presentation
  仙台
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-24791735
[Presentation] 鼻性NK/T細胞リンパ腫におけるc-Metを標的とした免疫療法の開発2016
- Author(s)
  熊井琢美, 大原賢三, 長門利純, 高原幹, 片田彰博, 林達哉, 小林博也, 原渕保明
- Organizer
  第117回日本耳鼻咽喉科学会総会
- Place of Presentation
  名古屋
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PROJECT-24791735
[Presentation] EGFR阻害薬による抗腫瘍免疫への影響について2015
- Author(s)
  熊井琢美, 大栗敬幸, 小坂朱, 長門利純, 石橋佳, 大原賢三, 平田結, 及川賢輔, 原渕保明, 小林博也
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-24791735
[Presentation] EGFR阻害薬によって腫瘍から放出される抑制性サイトカインは抗腫瘍免疫を低したさせうる2015
- Author(s)
  熊井琢美, 原渕保明, 小林博也
- Organizer
  第104回日本病理学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-24791735
[Presentation] EGFR反応性CD4陽性ヘルパーT細胞クローンの樹立及び EGFR阻害薬のアジュバントとしての有用性2013
- Author(s)
  熊井琢美
- Organizer
  日本耳鼻咽喉科学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24791735
[Presentation] EGFR inhibition augments anti-tumor immune responses by HER family-specific human CD4 helper T cells
- Author(s)
  熊井琢美
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24791735
[Presentation] EGFR inhibition augments anti-tumor immune responses by HER family-specific human CD4 helper T cells in vitro
- Author(s)
  熊井琢美
- Organizer
  AACR annual meeting 2013
- Place of Presentation
  Washington, D.C.
- Data Source
  KAKENHI-PROJECT-24791735
[Presentation] 腫瘍免疫におけるアジュバントとしての EGFR阻害薬の有用性
- Author(s)
  熊井琢美
- Organizer
  第31回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  倉敷
- Data Source
  KAKENHI-PROJECT-24791735
[Presentation] EGFR inhibition augments anti-tumor immune responses by HER family-specific human CD4 helper T cells in vitro
- Author(s)
  熊井琢美
- Organizer
  AACR annual meeting 2013
- Place of Presentation
  Washington, D.C.
- Data Source
  KAKENHI-PROJECT-24791735
[Presentation] 鼻性NK/T 細胞リンパ腫における新規c-MetヘルパT細胞エピトープの探索
- Author(s)
  熊井琢美
- Organizer
  第46回北海道病理談話会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-24390385
[Presentation] C-C chemokine receptor 4 is a remarkable molecule for novel targeted therapy against nasal natural killer/T-cell lymphoma
- Author(s)
  Toshihiro Nagato, Takumi Kumai, Hiroya Kobayashi, Yuki Komabayashi, Seigo Ueda, Kan Kishibe, Miki Takahara, Yasuaki Harabuchi
- Organizer
  16th International Symposium on EBV
- Place of Presentation
  Brisbane, Australia
- Year and Date
  2014-07-16 – 2014-07-19
- Data Source
  KAKENHI-PROJECT-24390385

1. HARABUCHI Yasuaki (80208686)

# of Collaborated Projects : 2results

# of Collaborated Products : 2results
2. TAKAHARA Miki (50322904)

# of Collaborated Projects : 2results

# of Collaborated Products : 2results
3. KISHIBE Kan (80447101)

# of Collaborated Projects : 2results

# of Collaborated Products : 2results
4. KOBAYASHI Hiroya (90280867)

# of Collaborated Projects : 2results

# of Collaborated Products : 6results
5. NAGATO Toshihiro (80431419)

# of Collaborated Projects : 2results

# of Collaborated Products : 2results
6. UEDA Seigo (90447102)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
7. KOMABAYASHI Yuki (40548864)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
8. 大原賢三 (20596308)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
9. 大栗敬幸 (70564061)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. 久保允人

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
11. 玉田耕治

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
12. 松下博和

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
13. 垣見和宏

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
14. 久米春喜

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
15. 中川徹

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
16. 西川博嘉

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
17. 坂口志文

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
18. 鈴木栄治

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
19. 三浦昌朋

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
20. 中西速夫

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
21. 大段秀樹

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
22. 田中友加

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
23. 廣橋良彦

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
24. 鳥越俊彦

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
25. 佐藤昇志

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

KUMAI Takumi 熊井 琢美

Research Projects

Research Products

Co-Researchers

鼻性NK/T細胞リンパ腫における免疫抑制機構の解明と新規免疫療法の開発Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

頭頸部癌に対する分子標的薬を中心としたアジュバントによる免疫療法の開発Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A foundational study for targeted therapy against EB virus and tumor growth factor in nasal NK/T-cell lymphoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

HER family targeted immunotherapy against head and neck squamous cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Peptide vaccines in cancer ― old concept revisited2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Optimization of Peptide Vaccines to Induce Robust Antitumor CD4 T-cell Responses2017

Author(s)

Journal Title

Data Source

[Journal Article] Novel targets for natural killer/T-cell lymphoma immunotherapy.2016

Author(s)

Journal Title

DOI

Language

Data Source

[Journal Article] Assessment of the change in cetuximab induced ADCC activity of NK cells by steroid2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting HER-3 to elicit antitumor helper T cells against head and neck squamous cell carcinoma.2015

Author(s)

Journal Title

DOI

Language

Data Source

[Journal Article] CCL17 and CCL22/CCR4 signaling is a strong candidate for novel targeted therapy against nasal natural killer/T-cell lymphoma2015

Author(s)

Journal Title

DOI

Language

Data Source

[Journal Article] ヘルパーT細胞と免疫アジュバントを用いた頭頸部癌免疫治療の開発2014

Author(s)

Journal Title

DOI

Language

Data Source

[Journal Article] EGFR inhibitors augment antitumour helper T-cell responses of HER family-specific immunotherapy2013

Author(s)

Journal Title

DOI

Language

Data Source

[Presentation] ヘルパーペプチドワクチンの実用化に向けたアジュバントの開発2018

Author(s)

Organizer

Data Source

[Presentation] Optimization of peptide vaccines to induce robust antitumor CD4 T-cell responses2018

Author(s)

Organizer

Data Source

KUMAI Takumi 熊井琢美

[Presentation] EGFR反応性CD4陽性ヘルパーT細胞クローンの樹立及び EGFR阻害薬のアジュバントとしての有用性2013