WAKAHARA Keiko 若原恵子

… Alternative Names

Wakahara Keiko 若原恵子

Less

Researcher Number	00631433
Other IDs
Affiliation (Current)	2025: 名古屋大学, 医学系研究科, 客員研究者
Affiliation (based on the past Project Information) *help	2024: 名古屋大学, 医学系研究科, 客員研究者 2017 – 2023: 名古屋大学, 医学部附属病院, 講師 2015: 名古屋大学, 医学部附属病院, 病院講師 2014: 名古屋大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / Basic Section 54020:Connective tissue disease and allergy-related / Collagenous pathology/Allergology Except Principal Investigator Basic Section 53030:Respiratory medicine-related / Medium-sized Section 53:Organ-based internal medicine and related fields / Respiratory surgery
Keywords	Principal Investigator 好塩基球 / COPD / 好酸球 / 気管支喘息 / treatable traits / united airway disease / 上気道細菌叢 / 末梢ヘルパーT細胞 / CD34 / 副鼻腔炎 … More / 関節リウマチ / 慢性副鼻腔炎 / 好酸球性肺疾患 / アレルギー性肺疾患 / 2型炎症 / 2型自然リンパ球 / 関節リウマチに伴う気道病変 / 慢性好酸球性肺炎 / ２型自然リンパ球 / 好酸球性炎症 / 樹状細胞 / 炎症性樹状細胞 … More Except Principal Investigator 肺線維症 / ミトコンドリアDNA / DAMPS / 肺傷害 / マクロファージ / 酸化ストレス / 自然免疫 / ミトコンドリア / 急性増悪 / 間質性肺疾患 / 診断 / 人工知能 / 血管内皮細胞 / マイクロCT / 金ナノ粒子 / 線維芽細胞 / 分子標的治療薬 / 抗癌剤 / 肺癌 / 低分子化合物 / がん幹細胞 / 肺がん Less

上気道炎症複合的プロファイルと下気道疾患・好塩基球の役割とtreatable traitsの探索Principal Investigator
- Principal Investigator
  
  若原恵子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Nagoya University
Basophil-mediated regulation of type 2 inflammation - allergic and eosinophilic lung diseases and lung homeostasisPrincipal Investigator
- Principal Investigator
  
  Wakahara Keiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Nagoya University
The role of mitochondrial DNA in the pathogenesis of acute exacerbation in interstitial lung diseases
- Principal Investigator
  
  Sakamoto Koji
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Nagoya University
Immune-pathological diagnostic artificial intelligence development research for pulmonary fibrosis using fibrotic foci-specific enhanced micro-CT
- Principal Investigator
  
  Hashimoto Naozumi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Fujita Health University
  Nagoya University
Basophils as potential refractory factors and biomarkers for chronic airway inflammationPrincipal Investigator
- Principal Investigator
  
  Wakahara Keiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Nagoya University
Analysis of bronchial asthma onset/exacerbation mechanism based on inflammatory dendritic cells and basophils.Principal Investigator
- Principal Investigator
  
  Wakahara Keiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Nagoya University
Identification of cancer initiating cell factors and an attempt of drug development
- Principal Investigator
  
  SUZUKI Motoshi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory surgery
- Research Institution
  Nagoya University

All 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Overexpression of bone morphogenetic protein receptor type 2 suppresses transforming growth factor β-induced profibrotic responses in lung fibroblasts2022
- Author(s)
  Fukihara Jun、Maiolo Suzanne、Kovac Jessica、Sakamoto Koji、Wakahara Keiko、Hashimoto Naozumi、Reynolds Paul N.
- Journal Title
  
  Experimental Lung Research
  
  Volume: 48 Issue: 1 Pages: 35-51
- DOI
  10.1080/01902148.2021.2024301
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08202, KAKENHI-PROJECT-20K21599, KAKENHI-PROJECT-18K15948
[Journal Article] Surgical strategy and optimal timing of tracheostomy in patients with COVID-19: Early experiences in Japan2021
- Author(s)
  Nishio Naoki、Hiramatsu Mariko、Goto Yukari、Shindo Yuichiro、Yamamoto Takanori、Jingushi Naruhiro、Wakahara Keiko、Sone Michihiko
- Journal Title
  
  Auris Nasus Larynx
  
  Volume: 48 Issue: 3 Pages: 518-524
- DOI
  10.1016/j.anl.2020.11.004
- NAID
  120007175385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08517, KAKENHI-PROJECT-18K08173
[Journal Article] Fibroblasts positive for meflin have anti-fibrotic properties in pulmonary fibrosis2021
- Author(s)
  Nakahara Y, Hashimoto N, Sakamoto K, Enomoto A, Adams TS, Yokoi T, Omote N, Poli S, Ando A, Wakahara K, Suzuki A, Inoue M, Hara A, Mizutani Y, Imaizumi K, Kawabe T, Rosas IO, Takahashi M, Kaminski N, Hasegawa Y.
- Journal Title
  
  European Respiratory Journal
  
  Volume: 58 Issue: 6 Pages: 2003397-2003397
- DOI
  10.1183/13993003.03397-2020
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07824, KAKENHI-PROJECT-21K08202, KAKENHI-PROJECT-20K21599, KAKENHI-PROJECT-18K15948, KAKENHI-PROJECT-20H03467
[Journal Article] CERS6 required for cell migration and metastasis in lung cancer.2020
- Author(s)
  Suzuki M, Cao K, Kato S, Mizutani N, Tanaka K, Arima C, Tai MC, Nakatani N, Yanagisawa K, Takeuchi T, Shi H, Mizutani Y, Niimi A, Taniguchi T, Fukui T, Yokoi K, Wakahara K, Hasegawa Y, Mizutani Y, Iwaki S, Fujii S, Satou A, Tamiya-Koizumi K, Murate T, Kyogashima M, Tomida S, Takahashi T.
- Journal Title
  
  J Cell Mol Med.
  
  Volume: 24 Issue: 20 Pages: 11949-11959
- DOI
  10.1111/jcmm.15817
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02468, KAKENHI-PROJECT-18H02698, KAKENHI-PROJECT-20H03771, KAKENHI-PROJECT-18K08174, KAKENHI-PROJECT-18K08173
[Journal Article] Bronchial wall thickening is associated with severity of chronic rhinosinusitis2020
- Author(s)
  Majima S, Wakahara K, Nishio T, Nishio N, Teranishi M, Iwano S, Hirakawa A, Hashimoto N, Sone M, Hasegawa Y.
- Journal Title
  
  Respir Med.
  
  Volume: 170 Pages: 106024-106024
- DOI
  10.1016/j.rmed.2020.106024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08173
[Journal Article] Omalizumab for Aspirin Hypersensitivity and Leukotriene Overproduction in Aspirin-exacerbated Respiratory Disease. A Randomized Controlled Trial2020
- Author(s)
  Hiroaki Hayashi , Yuma Fukutomi , Chihiro Mitsui , Keiichi Kajiwara , Kentaro Watai , Yosuke Kamide , Yuto Nakamura, Yuto Hamada , Yasuhiro Tomita , Kiyoshi Sekiya, Takahiro Tsuburai, Kenji Izuhara, Keiko Wakahara, Naozumi Hashimoto, Yoshinori Hasegawa, Masami Taniguchi
- Journal Title
  
  Am J Respir Crit Care Med.
  
  Volume: 201 Issue: 12 Pages: 1488-1498
- DOI
  10.1164/rccm.201906-1215oc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08173
[Journal Article] Mixed cell type in airway inflammation is the dominant phenotype in asthma patients with severe chronic rhinosinusitis2019
- Author(s)
  Nishio T, Wakahara K, Suzuki Y, Nishio N, Majima S, Nakamura S, Teranishi M, Nakatochi M, Sone M, Hasegawa Y
- Journal Title
  
  Allergol. Int.
  
  Volume: 68 Issue: 4 Pages: 515-520
- DOI
  10.1016/j.alit.2019.05.004
- NAID
  130007733182
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08173
[Journal Article] Longitudinal changes in pulmonary function and respiratory impedance of rheumatoid arthritis2019
- Author(s)
  Isobe Y, Ito S, Matsuda T, Iwano S, Uchida A, Takahashi N, Kojima T, Wakahara K, Yamaguchi E, Hasegawa Y
- Journal Title
  
  Repir Physiol Neurobiol
  
  Volume: 261 Pages: 1-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08173
[Journal Article] 重症喘息と気道炎症好酸球性炎症を中心として2018
- Author(s)
  若原恵子
- Journal Title
  
  日本職業・環境アレルギー学会雑誌
  
  Volume: 25 Pages: 37-45
- NAID
  40021621019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08173
[Journal Article] Airway basophils are increased and activated in eosinophilic asthma2017
- Author(s)
  Suzuki Y, Wakahara K, Nishio T, Ito S, Hasegawa Y
- Journal Title
  
  Allergy
  
  Volume: 72(10) Issue: 10 Pages: 1532-1539
- DOI
  10.1111/all.13197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09549
[Journal Article] Targeting ceramide synthase 6-dependent metastasis-prone phenotype in lung cancer cells.2016
- Author(s)
  Suzuki M, et al.
- Journal Title
  
  J. Clin. Invest.
  
  Volume: 126 Issue: 1 Pages: 254-265
- DOI
  10.1172/jci79775
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460203, KAKENHI-PROJECT-26460674, KAKENHI-PROJECT-15K12527, KAKENHI-PUBLICLY-26110717, KAKENHI-PROJECT-26889060, KAKENHI-PROJECT-25460217, KAKENHI-PROJECT-26670625, KAKENHI-PROJECT-25289299, KAKENHI-PROJECT-26290051, KAKENHI-PROJECT-25250017, KAKENHI-PLANNED-15H05910, KAKENHI-PROJECT-16H04767
[Presentation] COPDの気道壁の解析2020
- Author(s)
  中村さや、若原恵子、馬嶋俊、横井英人、橋本直純、長谷川好規
- Organizer
  第60回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K08173
[Presentation] COPD患者における脳萎縮と臨床的意COPDおける脳容積と身体活動量に関する研究2020
- Author(s)
  馬嶋俊、若原恵子、西尾朋子、中村さや、池田由香里、蛯名潤哉、原一洋、渡辺宏久、祖父江元、長谷川好規
- Organizer
  第60回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K08173
[Presentation] Mixed cellular inflammation is increased in adult asthma with severe chronic rhinosinusitis2019
- Author(s)
  Nishio T, Wakahara K, Suzuki Y, Majima S, Nishio N, Teranishi M, Sone M, Hasegawa Y
- Organizer
  American Academy of Allergy Asthma & Immunology annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08173
[Presentation] Relationship of physical activity level with musculoskeletal conditions and inflammation in COPD patients without comorbidities2019
- Author(s)
  Majima S, Wakahara K, Nishio T, Nakamura S, Sashio T, Asano S, Hasegawa Y
- Organizer
  American Thoracic Society international conference 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08173
[Presentation] 気道炎症に対する細胞生物学的アプローチ　好塩基球2018
- Author(s)
  若原恵子
- Organizer
  第24回国際喘息学会日本・北アジア部会
- Data Source
  KAKENHI-PROJECT-18K08173
[Presentation] Increasing sputum basophils is a marker for eosinophil-dominant airway inflammation in adult asthma2018
- Author(s)
  Wakahara K, Nishio T, Suzuki Y, Majima S, Nakamura S, Hasegawa Y
- Organizer
  European Respiratory Society Annual Congress 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08173
[Presentation] Periostin levels in chronic obstructive pulmonary disease (COPD)2018
- Author(s)
  Nakamura S, Wakahara K, Majima S, Nishio T, Suzuki Y, Shiraki A, Abe T, Shindoh J, Sashio T, Ono J, Izuhara K, Hasegawa Y
- Organizer
  European Respiratory Society Annual Congress 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08173
[Presentation] Flow cytometric analysis of induced sputum to evaluate eosinophilic inflammation2017
- Author(s)
  Wakahara K, Suzuki Y, NIshio T, Majima S, Hasegawa Y
- Organizer
  アジア太平洋呼吸器学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09549
[Presentation] Airway Basophils Are Activated and Associated with Eosinophilic Inflammation in Asthmatic Patients2016
- Author(s)
  Yoshihiro Suzuki, Keiko Wakahara, Tomoko Nishio, Satoru Ito, Yoshinori Hasegawa
- Organizer
  アメリカアレルギー学会
- Place of Presentation
  ロサンゼルス, アメリカ
- Year and Date
  2016-03-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09549

1. Sakamoto Koji (00635633)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. Hashimoto Naozumi (30378020)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. SUZUKI Motoshi (80236017)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. FUKUI Takayuki (70463198)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KATO Sei-ichi (30584669)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Nishida Atsushi (80130029)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 中村彰太 (20612849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 古川大記 (30837654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 芳川豊史 (00452334)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 猪股弥生 (90469792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 齋藤研 (60964880)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SUZUKI Yoshihiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. NISHIO Tomoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. KAWABE Tsutomu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 高橋隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 進藤有一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

WAKAHARA Keiko 若原 恵子

Wakahara Keiko 若原 恵子

Research Projects

Research Products

Co-Researchers

上気道炎症複合的プロファイルと下気道疾患・好塩基球の役割とtreatable traitsの探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Basophil-mediated regulation of type 2 inflammation - allergic and eosinophilic lung diseases and lung homeostasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of mitochondrial DNA in the pathogenesis of acute exacerbation in interstitial lung diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Immune-pathological diagnostic artificial intelligence development research for pulmonary fibrosis using fibrotic foci-specific enhanced micro-CT

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Basophils as potential refractory factors and biomarkers for chronic airway inflammationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of bronchial asthma onset/exacerbation mechanism based on inflammatory dendritic cells and basophils.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of cancer initiating cell factors and an attempt of drug development

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Overexpression of bone morphogenetic protein receptor type 2 suppresses transforming growth factor β-induced profibrotic responses in lung fibroblasts2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Surgical strategy and optimal timing of tracheostomy in patients with COVID-19: Early experiences in Japan2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Fibroblasts positive for meflin have anti-fibrotic properties in pulmonary fibrosis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CERS6 required for cell migration and metastasis in lung cancer.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bronchial wall thickening is associated with severity of chronic rhinosinusitis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Omalizumab for Aspirin Hypersensitivity and Leukotriene Overproduction in Aspirin-exacerbated Respiratory Disease. A Randomized Controlled Trial2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mixed cell type in airway inflammation is the dominant phenotype in asthma patients with severe chronic rhinosinusitis2019

Author(s)

WAKAHARA Keiko 若原恵子

Wakahara Keiko 若原恵子

[Journal Article] 重症喘息と気道炎症好酸球性炎症を中心として2018

[Presentation] 気道炎症に対する細胞生物学的アプローチ　好塩基球2018