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Kubo Tomohiro  久保 智洋

ORCIDConnect your ORCID iD *help
Researcher Number 00634669
Affiliation (Current) 2025: 札幌医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help 2019 – 2024: 札幌医科大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 53010:Gastroenterology-related / 0901:Oncology and related fields
Except Principal Investigator
Basic Section 53010:Gastroenterology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords
Principal Investigator
NK細胞 / HDAC阻害剤 / 肝細胞癌 / 選択的Class Ⅱa HDAC阻害薬 / CIML NK cell / 胃癌 / 細胞障害活性 / 免疫療法
Except Principal Investigator
肝細胞癌 / NK細胞 … More / CIML / 効果予測因子 / 感受性予測 / miRNA / 化学放射線療法 / 食道癌 / 耐性機構 / TIM-3 / TIGIT / 固形癌 / CIML NK細胞 / 膵臓癌 / CAR / CAR-NK / 薬剤感受性 / 放射線感受性 Less
  • Research Projects

    (7 results)
  • Research Products

    (2 results)
  • Co-Researchers

    (7 People)
  •  Development of immunotherapy for hepatocellular carcinoma premedicated with a novel liposomal agent.

    • Principal Investigator
      大須賀 崇裕
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Sapporo Medical University
  •  A novel treatment for hepatocellular carcinoma using CIML NK cells, TIM-3, and TIGIT inhibitors

    • Principal Investigator
      宮西 浩嗣
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Sapporo Medical University
  •  Analyzing and overcoming chemoradiation resistance mechanism for esophageal squamous cell carcinoma through miRNA functional analysis

    • Principal Investigator
      大沼 啓之
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Sapporo Medical University
  •  Novel strategies for the treatment of solid tumors with CAR and CIML NK cells

    • Principal Investigator
      Miyanishi Koji
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Sapporo Medical University
  •  Antitumor effect of histone deacetylase class IIa inhibitor with CIML NK cell in hepatocellular cell carcinomaPrincipal Investigator

    • Principal Investigator
      Kubo Tomohiro
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Sapporo Medical University
  •  Establishment of a system by miRNA analysis to predict prognoses of cases with esophageal squamous cell carcinoma treated by chemoradiotherapy.

    • Principal Investigator
      Ohnuma Hiroyuki
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Sapporo Medical University
  •  Analysis of each subset of CIML NK cells and development of new therapy for gastric cancerPrincipal Investigator

    • Principal Investigator
      Kubo Tomohiro
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Review Section
      0901:Oncology and related fields
    • Research Institution
      Sapporo Medical University

All 2022 2021

All Journal Article Presentation

  • [Journal Article] Impaired T- and NK-cell reconstitution after haploidentical HCT with posttransplant cyclophosphamide2021

    • Author(s)
      Benedetta Rambaldi, Haesook T. Kim, Carol Reynolds, Sharmila Chamling Rai, Yohei Arihara, Tomohiro Kubo, Leutz Buon, Mahasweta Gooptu, John Koreth, Corey Cutler, Sarah Nikiforow, Vincent T. Ho, Edwin P. Alyea, Joseph H. Antin, Catherine J. Wu, Robert J. Soiffer, Jerome Ritz, and Rizwan Romee
    • Journal Title

      Blood Advances

      Volume: 26 Issue: 2 Pages: 352-364

    • DOI

      10.1182/bloodadvances.2020003005

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K23892
  • [Presentation] 肝細胞癌に対するLenvatinibとHDAC class IIa選択阻害薬併用療法の有用性の検討2022

    • Author(s)
      久保智洋,伊藤亮,宮西浩嗣,大須賀崇裕,田中信悟,大沼啓之,村瀬和幸,高田弘一,加藤淳二
    • Organizer
      第26回日本肝臓学会大会
    • Data Source
      KAKENHI-PROJECT-21K15954
  • 1.  Miyanishi Koji (60372819)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 2.  大須賀 崇裕 (40619714)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  Ohnuma Hiroyuki (60582997)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  加藤 淳二 (20244345)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  田中 信悟 (60561024)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  濱口 孝太 (50866613)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  高田 弘一 (90398321)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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