Hosomi Koji 細見晃司

Researcher Number	00755762
Other IDs
Affiliation (Current)	2025: 大阪公立大学, 大学院獣医学研究科 , 准教授 2025: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所ヘルス・メディカル微生物研究センター, 客員研究員
Affiliation (based on the past Project Information) *help	2023: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所ヘルス・メディカル微生物研究センター, 主任研究員 2022: 国立研究開発法人医薬基盤・健康・栄養研究所, その他部局等, 研究員 2021 – 2022: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所ワクチン・アジュバント研究センター, 主任研究員 2018 – 2021: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所ワクチン・アジュバント研究センター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 42020:Veterinary medical science-related / Basic Section 59040:Nutrition science and health science-related Except Principal Investigator Basic Section 59020:Sports sciences-related / Basic Section 54030:Infectious disease medicine-related
Keywords	Principal Investigator 腸炎 / カンピロバクター / エネルギー代謝 / ワクチン / メタボリズム / 細菌感染症 / 抗体 / 微生物メタボリズム / 神経障害 / 自己免疫応答 … More / ギラン・バレー症候群 / リンパ組織内共生 / LPS活性 / アポトーシス / 腸管免疫 / アルカリゲネス / リピドA / 粘膜免疫 / アジュバント / パイエル板 / 共生細菌 / LPS / ミトコンドリア / 代謝 / 一酸化窒素 / 樹状細胞 / 免疫 / 共生 / 腸内細菌 … More Except Principal Investigator 腸内細菌叢 / 身体活動 / 乳がん / 乳癌 / 簡易型自記式食事歴法質問票（BDHQ） / 腸内細菌叢解析 / 肺非結核性抗酸菌症 Less

カンピロバクター感染における自己免疫応答と神経障害の包括的理解と病態解明Principal Investigator
- Principal Investigator
  
  細見晃司
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
乳がん予防を目的とした身体活動基準の策定のための基盤研究
- Principal Investigator
  
  北村裕美
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  University of Marketing and Distribution Sciences
微生物メタボリズムからのカンピロバクター腸炎発症メカニズムの理解Principal Investigator
- Principal Investigator
  
  細見晃司
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
Analysis of the relationship between the gut microbiome and pulmonary non-tuberculous mycobacteriosis
- Principal Investigator
  
  今村圭文
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Nagasaki University
Immune modulation by a symbiotic bacterium Alcaligenes in gut associated lymphoid tissuesPrincipal Investigator
- Principal Investigator
  
  Hosomi Koji
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition

All 2023 2022 2021 2020 2019 2018 Other

All Journal Article Presentation Book Other

[Book] 腸内環境を介した免疫制御とワクチン研究への展開2022
- Author(s)
  吉井健、細見晃司、國澤純
- Total Pages
  6
- Publisher
  Precision Medicine
- Data Source
  KAKENHI-PROJECT-22K15004
[Book] ポストバイオティクス研究から考える健康科学の将来と個別化栄養2022
- Author(s)
  細見晃司、國澤純
- Total Pages
  6
- Publisher
  FOOD STYLE 21
- Data Source
  KAKENHI-PROJECT-22K15004
[Book] 食と腸内細菌から考える健康長寿最前線2022
- Author(s)
  細見晃司、國澤純
- Publisher
  アンチ・エイジング医学
- Data Source
  KAKENHI-PROJECT-18K17997
[Book] 粘膜面における獲得免疫と感染防御2021
- Author(s)
  細見晃司、國澤純
- Total Pages
  6
- Publisher
  医学のあゆみ
- Data Source
  KAKENHI-PROJECT-18K17997
[Book] 腸内細菌の代謝物を介した免疫機能制御2021
- Author(s)
  吉井健、細見晃司、國澤純
- Total Pages
  11
- Publisher
  腸内細菌学雑誌
- Data Source
  KAKENHI-PROJECT-18K17997
[Book] 栄養学と腸内細菌から考える個別化医療の将来展望2019
- Author(s)
  細見晃司、國澤純
- Total Pages
  4
- Publisher
  Precision Medicine
- Data Source
  KAKENHI-PROJECT-18K17997
[Book] 油と腸内フローラから考える健康科学の新展開2019
- Author(s)
  細見晃司、國澤純
- Total Pages
  8
- Publisher
  イルシー
- Data Source
  KAKENHI-PROJECT-18K17997
[Book] ヒトマイクロバイオームビッグデータと健康医療への応用2018
- Author(s)
  細見晃司、國澤純
- Total Pages
  6
- Publisher
  月刊化学工業
- Data Source
  KAKENHI-PROJECT-18K17997
[Book] 腸内環境に関連するビッグデータの集積と創薬、機能性食品開発への展望. 腸内細菌叢を標的にした医薬品と保健機能食品の開発2018
- Author(s)
  細見晃司、國澤純
- Total Pages
  7
- Publisher
  技術情報協会
- Data Source
  KAKENHI-PROJECT-18K17997
[Journal Article] Alcaligenes lipid A functions as a superior mucosal adjuvant to monophosphoryl lipid A via the recruitment and activation of CD11b+ dendritic cells in nasal tissue2023
- Author(s)
  Sun Xiao、Hosomi Koji、Shimoyama Atsushi、Yoshii Ken、Saika Azusa、Yamaura Haruki、Nagatake Takahiro、Kiyono Hiroshi、Fukase Koichi、Kunisawa Jun
- Journal Title
  
  International Immunology
  
  Volume: 36 Issue: 1 Pages: 33-43
- DOI
  10.1093/intimm/dxad045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15004, KAKENHI-PROJECT-22KJ2152, KAKENHI-PROJECT-20H05675
[Journal Article] TLR4 agonist activity of Alcaligenes lipid a utilizes MyD88 and TRIF signaling pathways for efficient antigen presentation and T cell differentiation by dendritic cells2023
- Author(s)
  Sun Xiao、Hosomi Koji、Shimoyama Atsushi、Yoshii Ken、Lan Huangwenxian、Wang Yunru、Yamaura Haruki、Nagatake Takahiro、Ishii Ken J.、Akira Shizuo、Kiyono Hiroshi、Fukase Koichi、Kunisawa Jun
- Journal Title
  
  International Immunopharmacology
  
  Volume: 117 Pages: 109852-109852
- DOI
  10.1016/j.intimp.2023.109852
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H05675, KAKENHI-PROJECT-22KJ2152, KAKENHI-PROJECT-20K05749, KAKENHI-PROJECT-22K15004, KAKENHI-PROJECT-18H05280
[Journal Article] Induction of unique macrophage subset by simultaneous stimulation with LPS and IL-42023
- Author(s)
  Ishida Kei、Nagatake Takahiro、Saika Azusa、Kawai Soichiro、Node Eri、Hosomi Koji、Kunisawa Jun
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 1111729-1111729
- DOI
  10.3389/fimmu.2023.1111729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15004
[Journal Article] Endotoxin-Free Stx2B-C-CPE Vaccine and Its Optimized Adjuvant Regimen for Preventing Food Poisoning2023
- Author(s)
  Hosomi Koji、Shimoyama Atsushi、Hinenoya Atsushi、Hatanaka Noritoshi、Noguchi Takafumi、Ebina Hirotaka、Tojima Yoko、Furuta Mari、Kondoh Masuo、Kiyono Hiroshi、Yamasaki Shinji、Fukase Koichi、Kunisawa Jun
- Journal Title
  
  Frontiers in Bioscience-Landmark
  
  Volume: 28 Issue: 1 Pages: 15-15
- DOI
  10.31083/j.fbl2801015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06396, KAKENHI-PROJECT-22K18378, KAKENHI-PROJECT-20H05675, KAKENHI-PROJECT-20K05749, KAKENHI-PROJECT-22K15004, KAKENHI-PROJECT-18H05280
[Journal Article] The Gut Microbiome as a Biomarker of Cancer Progression Among Female Never-smokers With Lung Adenocarcinoma2022
- Author(s)
  OTOSHI TAKEHIRO、NAGANO TATSUYA、PARK JONGUK、HOSOMI KOJI、YAMASHITA TOMOYA、TACHIHARA MOTOKO、TABATA TOKIKO、SEKIYA REINA、TANAKA YUGO、KOBAYASHI KAZUYUKI、MIZUGUCHI KENJI、ITOH TOMOO、MANIWA YOSHIMASA、KUNISAWA JUN、NISHIMURA YOSHIHIRO
- Journal Title
  
  Anticancer Research
  
  Volume: 42 Issue: 3 Pages: 1589-1598
- DOI
  10.21873/anticanres.15633
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K17997, KAKENHI-PROJECT-20K08567
[Journal Article] Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques2022
- Author(s)
  Nagatake T, Kishino S, Urano E, et al.
- Journal Title
  
  Mucosal Immunology
  
  Volume: 15 Issue: 2 Pages: 289-300
- DOI
  10.1038/s41385-021-00477-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07617, KAKENHI-PROJECT-20K21643, KAKENHI-WRAPUP-20H05613, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-20H00495, KAKENHI-PROJECT-20H03444, KAKENHI-PROJECT-21H03371, KAKENHI-PROJECT-20K06455, KAKENHI-PROJECT-20K07333, KAKENHI-PROJECT-22K15004, KAKENHI-PROJECT-21K19395, KAKENHI-PROJECT-23K20389, KAKENHI-PROJECT-21H02757
[Journal Article] Relationships between barley consumption and gut microbiome characteristics in a healthy Japanese population: a cross-sectional study2022
- Author(s)
  Matsuoka Tsubasa、Hosomi Koji、Park Jonguk、Goto Yuka、Nishimura Mao、Maruyama Satoko、Murakami Haruka、Konishi Kana、Miyachi Motohiko、Kawashima Hitoshi、Mizuguchi Kenji、Kobayashi Toshiki、Yokomichi Hiroshi、Kunisawa Jun、Yamagata Zentaro
- Journal Title
  
  BMC Nutrition
  
  Volume: 8 Issue: 1 Pages: 23-23
- DOI
  10.1186/s40795-022-00500-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17997, KAKENHI-PROJECT-18K17376, KAKENHI-PROJECT-22K15004
[Journal Article] Classification of the Occurrence of Dyslipidemia Based on Gut Bacteria Related to Barley Intake2022
- Author(s)
  Maruyama Satoko、Matsuoka Tsubasa、Hosomi Koji、Park Jonguk、Nishimura Mao、Murakami Haruka、Konishi Kana、Miyachi Motohiko、Kawashima Hitoshi、Mizuguchi Kenji、Kobayashi Toshiki、Ooka Tadao、Yamagata Zentaro、Kunisawa Jun
- Journal Title
  
  Frontiers in Nutrition
  
  Volume: 9 Pages: 812469-812469
- DOI
  10.3389/fnut.2022.812469
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15004
[Journal Article] Identification of Human Gut Microbiome Associated with Enterolignan Production2022
- Author(s)
  Sawane Kento、Hosomi Koji、Park Jonguk、Ookoshi Kouta、Nanri Hinako、Nakagata Takashi、Chen Yi-An、Mohsen Attayeb、Kawashima Hitoshi、Mizuguchi Kenji、Miyachi Motohiko、Kunisawa Jun
- Journal Title
  
  Microorganisms
  
  Volume: 10 Issue: 11 Pages: 2169-2169
- DOI
  10.3390/microorganisms10112169
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15004
[Journal Article] Utilization of gut environment-mediated control system of host immunity in the development of vaccine adjuvants2022
- Author(s)
  Liu Zilai、Hosomi Koji、Kunisawa Jun
- Journal Title
  
  Vaccine
  
  Volume: 40 Issue: 36 Pages: 5399-5403
- DOI
  10.1016/j.vaccine.2022.07.031
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15004
[Journal Article] Dietary Vitamin B1 Intake Influences Gut Microbial Community and the Consequent Production of Short-Chain Fatty Acids2022
- Author(s)
  Park J, Hosomi K, Kawashima H, Chen YA, Mohsen A, Ohno H, Konishi K, Tanisawa K, Kifushi M, Kogawa M, Takeyama H, Murakami H, Kubota T, Miyachi M, Kunisawa J, Mizuguchi K.
- Journal Title
  
  Nutrients
  
  Volume: 14 Issue: 10 Pages: 2078-2078
- DOI
  10.3390/nu14102078
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08640, KAKENHI-PROJECT-21K15267, KAKENHI-PROJECT-22K15004, KAKENHI-PROJECT-20H04117
[Journal Article] Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota2022
- Author(s)
  Hosomi K, Saito M, Park J, Murakami H, Shibata N, Ando M, Nagatake T, Konishi K, Ohno H, Tanisawa K, Mohsen A, Chen YA, Kawashima H, Natsume-Kitatani Y, Oka Y, Shimizu H, Furuta M, Tojima Y, Sawane K, Saika A, Kondo S, Yonejima Y, Takeyama H, Matsutani A, Mizuguchi K, Miyachi M, Kunisawa J
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 4477-4477
- DOI
  10.1038/s41467-022-32015-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K17561, KAKENHI-PROJECT-22K15004, KAKENHI-PROJECT-22KJ3213, KAKENHI-PROJECT-20H04117, KAKENHI-PROJECT-21H02757
[Journal Article] Lipopolysaccharide Derived From the Lymphoid-Resident Commensal Bacteria Alcaligenes faecalis Functions as an Effective Nasal Adjuvant to Augment IgA Antibody and Th17 Cell Responses2021
- Author(s)
  Wang Yunru、Hosomi Koji、Shimoyama Atsushi、Yoshii Ken、Nagatake Takahiro、Fujimoto Yukari、Kiyono Hiroshi、Fukase Koichi、Kunisawa Jun
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 699349-699349
- DOI
  10.3389/fimmu.2021.699349
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17997, KAKENHI-PROJECT-18H02674, KAKENHI-PUBLICLY-20H04776, KAKENHI-PROJECT-20H05675, KAKENHI-PROJECT-20K05749, KAKENHI-PROJECT-18H05280
[Journal Article] Categorization of the Ocular Microbiome in Japanese Stevens?Johnson Syndrome Patients With Severe Ocular Complications2021
- Author(s)
  Ueta Mayumi、Hosomi Koji、Park Jonguk、Mizuguchi Kenji、Sotozono Chie、Kinoshita Shigeru、Kunisawa Jun
- Journal Title
  
  Frontiers in Cellular and Infection Microbiology
  
  Volume: 11 Pages: 741654-741654
- DOI
  10.3389/fcimb.2021.741654
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17997, KAKENHI-PROJECT-19H03809
[Journal Article] 12-Hydroxyeicosapentaenoic acid inhibits foam cell formation and ameliorates high-fat diet-induced pathology of atherosclerosis in mice2021
- Author(s)
  Nagatake T, Shibata Y, Morimoto S, Node E, Sawane K, Hirata SI, Adachi J, Abe Y, Isoyama J, Saika A, Hosomi K, Tomonaga T, and Kunisawa J.
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 10426-10426
- DOI
  10.1038/s41598-021-89707-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07617, KAKENHI-PROJECT-18K17997, KAKENHI-PROJECT-20K07333, KAKENHI-PROJECT-21H02757, KAKENHI-PROJECT-23K20389
[Journal Article] Chemically Synthesized Alcaligenes Lipid A as an Adjuvant to Augment Immune Responses to Haemophilus Influenzae Type B Conjugate Vaccine2021
- Author(s)
  Liu Zilai、Hosomi Koji、Shimoyama Atsushi、Yoshii Ken、Sun Xiao、Lan Huangwenxian、Wang Yunru、Yamaura Haruki、Kenneth Davie、Saika Azusa、Nagatake Takahiro、Kiyono Hiroshi、Fukase Koichi、Kunisawa Jun
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 12 Pages: 763657-763657
- DOI
  10.3389/fphar.2021.763657
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K17997, KAKENHI-PUBLICLY-20H04776, KAKENHI-PROJECT-20H05675, KAKENHI-PROJECT-20K05749
[Journal Article] Comprehensive analysis of gut microbiota of a healthy population and covariates affecting microbial variation in two large Japanese cohorts2021
- Author(s)
  Park J, Kato K, Murakami H, Hosomi K, Tanisawa K, Nakagata T, Ohno H, Konishi K, Kawashima H, Chen YA, Mohsen A, Xiao JZ, Odamaki T, Kunisawa J, Mizuguchi K, Miyachi M
- Journal Title
  
  BMC Microbiol
  
  Volume: 21 Issue: 1 Pages: 151-151
- DOI
  10.1186/s12866-021-02215-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11612, KAKENHI-PROJECT-18K17997, KAKENHI-PROJECT-20H04117
[Journal Article] Lipopolysaccharide from Gut‐Associated Lymphoid‐Tissue‐Resident Alcaligenes faecalis : Complete Structure Determination and Chemical Synthesis of Its Lipid?A2021
- Author(s)
  Shimoyama A、Di Lorenzo F、Yamaura H、Mizote K、Palmigiano A、Pither MD.、Speciale I、Uto T、Masui S、Sturiale L、Garozzo D、Hosomi K、Shibata N、Kabayama K、Fujimoto Y、Silipo A、Kunisawa Jun、Kiyono H、Molinaro A、Fukase K
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 60 Issue: 18 Pages: 10023-10031
- DOI
  10.1002/anie.202012374
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05356, KAKENHI-PROJECT-20K05749, KAKENHI-PROJECT-18K17997, KAKENHI-PLANNED-15H05836, KAKENHI-PUBLICLY-20H04776, KAKENHI-PROJECT-20H05675, KAKENHI-PROJECT-18H05280, KAKENHI-PROJECT-18H02674
[Journal Article] ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α2021
- Author(s)
  Saika, A., Nagatake, T., Hirata, S.I., Sawane, K., Adachi, J., Abe, Y., Isoyama, J., Morimoto, S., Node, E., Tiwari, P., Hosomi, K., Matsunaga, A., Honda, T., Tomonaga, T., Arita, M., Kabashima, K., and Kunisawa, J.
- Journal Title
  
  FASEB J
  
  Volume: 35 Issue: 4
- DOI
  10.1096/fj.202001687r
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03749, KAKENHI-PROJECT-19K07617, KAKENHI-PROJECT-18K17997, KAKENHI-WRAPUP-20H05613, KAKENHI-PROJECT-20H00495, KAKENHI-PROJECT-21H02757
[Journal Article] Impact of the intestinal environment on the immune responses to vaccination2020
- Author(s)
  Hosomi Koji、Kunisawa Jun
- Journal Title
  
  Vaccine
  
  Volume: 38 Issue: 44 Pages: 6959-6965
- DOI
  10.1016/j.vaccine.2020.08.079
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K17997, KAKENHI-PROJECT-18H02674
[Journal Article] Chemically Synthesized Alcaligenes Lipid A Shows a Potent and Safe Nasal Vaccine Adjuvant Activity for the Induction of Streptococcus pneumoniae-Specific IgA and Th17 Mediated Protective Immunity2020
- Author(s)
  Yoshii Ken、Hosomi Koji、Shimoyama Atsushi、Wang Yunru、Yamaura Haruki、Nagatake Takahiro、Suzuki Hidehiko、Lan Huangwenxian、Kiyono Hiroshi、Fukase Koichi、Kunisawa Jun
- Journal Title
  
  Microorganisms
  
  Volume: 8 Issue: 8 Pages: 1102-1102
- DOI
  10.3390/microorganisms8081102
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05749, KAKENHI-PROJECT-18K17997, KAKENHI-PLANNED-15H05836, KAKENHI-PUBLICLY-20H04776, KAKENHI-PROJECT-20H05675, KAKENHI-PROJECT-20H00404, KAKENHI-PROJECT-19KK0145, KAKENHI-PROJECT-18H05280, KAKENHI-PROJECT-18H02674
[Journal Article] Maternal omega-3 docosapentaenoic acid inhibits infant allergic dermatitis through TRAIL-expressing plasmacytoid dendritic cells in mice2020
- Author(s)
  Hirata SI, Nagatake T, Sawane K, Hosomi K, Honda T, Ono S, Shibuya N, Saito E, Adachi J, Abe Y, Isoyama J, Suzuki H, Matsunaga A, Tomonaga T, Kiyono H, Kabashima K, Arita M, and Kunisawa J
- Journal Title
  
  Allergy
  
  Volume: - Issue: 8 Pages: 0-0
- DOI
  10.1111/all.14217
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07617, KAKENHI-PROJECT-18K17997, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05898, KAKENHI-PROJECT-18K17996, KAKENHI-PROJECT-18H05280
[Journal Article] Impaired Mucociliary Motility Enhances Antigen-Specific Nasal IgA Immune Responses to a Cholera Toxin-Based Nasal Vaccine2020
- Author(s)
  Lan H, Suzuki H, Nagatake T, Hosomi K, Ikegami K, Setou M, Kunisawa J.
- Journal Title
  
  Int Immunol
  
  Volume: in press Issue: 8 Pages: 559-568
- DOI
  10.1093/intimm/dxaa029
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17997, KAKENHI-PROJECT-18H02674
[Journal Article] Lymphoid Tissue Resident Alcaligenes Establish an Intracellular Symbiotic Environment by Creating a Unique Energy Shift in Dendritic Cells2020
- Author(s)
  Hosomi Koji、Shibata Naoko、Shimoyama Atsushi、Uto Tomoya、Nagatake Takahiro、Tojima Yoko、Nishino Tomomi、Takeyama Haruko、Fukase Koichi、Kiyono Hiroshi、Kunisawa Jun
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 11 Pages: 561005-561005
- DOI
  10.3389/fmicb.2020.561005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05749, KAKENHI-PROJECT-18K17997, KAKENHI-PLANNED-15H05836, KAKENHI-PUBLICLY-20H04776, KAKENHI-PROJECT-20H05675, KAKENHI-PROJECT-20H00404, KAKENHI-PROJECT-17J07480, KAKENHI-PROJECT-17K17686, KAKENHI-PROJECT-19KK0145, KAKENHI-PROJECT-18H05280, KAKENHI-PROJECT-18H02674
[Journal Article] Diversity of Energy Metabolism in Immune Responses Regulated by Microorganisms and Dietary Nutrition2020
- Author(s)
  Hosomi K, Kunisawa J
- Journal Title
  
  Int Immunol
  
  Volume: in press Issue: 7 Pages: 447-454
- DOI
  10.1093/intimm/dxaa020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17997, KAKENHI-PROJECT-18H02674
[Journal Article] Adjuvant Activity of Synthetic Lipid A of Alcaligenes, a Gut-Associated Lymphoid Tissue-Resident Commensal Bacterium, to Augment Antigen-Specific IgG and Th17 Responses in Systemic Vaccine2020
- Author(s)
  Wang Yunru、Hosomi Koji、Shimoyama Atsushi、Yoshii Ken、Yamaura Haruki、Nagatake Takahiro、Nishino Tomomi、Kiyono Hiroshi、Fukase Koichi、Kunisawa Jun
- Journal Title
  
  Vaccines
  
  Volume: 8 Issue: 3 Pages: 395-395
- DOI
  10.3390/vaccines8030395
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05749, KAKENHI-PROJECT-18K17997, KAKENHI-PLANNED-15H05836, KAKENHI-PUBLICLY-20H04776, KAKENHI-PROJECT-20H05675, KAKENHI-PROJECT-20H00404, KAKENHI-PROJECT-19KK0145, KAKENHI-PROJECT-18H05280, KAKENHI-PROJECT-18H02674
[Journal Article] Clostridium Perfringens Enterotoxin-Based Protein Engineering for the Vaccine Design and Delivery System2019
- Author(s)
  Lan H, Hosomi K, Kunisawa J.
- Journal Title
  
  Vaccine
  
  Volume: 37 Issue: 42 Pages: 6232-6232
- DOI
  10.1016/j.vaccine.2019.08.032
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17997, KAKENHI-PROJECT-18H02674
[Journal Article] Dietary omega-3 fatty acid dampens allergic rhinitis via eosinophilic production of the anti-allergic lipid mediator 15-hydroxyeicosapentaenoic acid in mice2019
- Author(s)
  Sawane K, Nagatake T, Hosomi K, Hirata SI, Adachi J, Abe Y, Isoyama J, Suzuki H, Matsunaga A, Fukumitsu S, Aida K, Tomonaga T, Arita M, and Kunisawa J
- Journal Title
  
  Nutrients
  
  Volume: 11 Issue: 12 Pages: 2868-2868
- DOI
  10.3390/nu11122868
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07617, KAKENHI-PROJECT-18K17997, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05898
[Journal Article] Metabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity2019
- Author(s)
  Yoshii Ken、Hosomi Koji、Sawane Kento、Kunisawa Jun
- Journal Title
  
  Frontiers in Nutrition
  
  Volume: 6 Pages: 48-48
- DOI
  10.3389/fnut.2019.00048
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18J00556, KAKENHI-PROJECT-18K17997
[Journal Article] Analysis of Oral Microbiota in Japanese Oral Cancer Patients Using 16S rRNA Sequencing2019
- Author(s)
  Takahashi Y, Park J, Hosomi K, Yamada T, Kobayashi A, Yamaguchi Y, Iketani S, Kunisawa J, Mizuguchi K, Maeda N, Ohshima T.
- Journal Title
  
  J Oral Biosci .
  
  Volume: 61 Issue: 2 Pages: 120-120
- DOI
  10.1016/j.job.2019.03.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17997
[Journal Article] 17( S),18( R)-epoxyeicosatetraenoic Acid Generated by Cytochrome P450 BM-3 From Bacillus megaterium Inhibits the Development of Contact Hypersensitivity via G-protein-coupled Receptor 40-mediated Neutrophil Suppression2019
- Author(s)
  Saika A, Nagatake T, Kishino S, Park SB, Honda T, Matsumoto N, Shimojou M, Morimoto S, Tiwari P, Node E, Hirata SI, Hosomi K, Kabashima K, Ogawa J, Kunisawa J.
- Journal Title
  
  FASEB Bioadv .
  
  Volume: 2 Pages: 59-59
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17997
[Journal Article] BLT1 Mediates Commensal Bacteria-Dependent Innate Immune Signals to Enhance Antigen-Specific Intestinal IgA Responses2019
- Author(s)
  Nagatake T, Hirata SI, Koga T, Kuroda E, Kobari S, Suzuki H, Hosomi K, Matsumoto N, Yanrismet Y, Shimojou M, Morimoto S, Sasaki F, Ishii KJ, Yokomizo T, Kunisawa J.
- Journal Title
  
  Mucosal Immunol .
  
  Volume: 12 Issue: 5 Pages: 1082-1082
- DOI
  10.1038/s41385-019-0175-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17997, KAKENHI-PROJECT-19KK0199, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05904, KAKENHI-PROJECT-18H02627, KAKENHI-PROJECT-18H02674
[Journal Article] Fatty Acid Metabolism in the Host and Commensal Bacteria for the Control of Intestinal Immune Responses and Diseases2019
- Author(s)
  Hosomi K, Kiyono H, Kunisawa J.
- Journal Title
  
  Gut Microbes
  
  Volume: 23 Issue: 3 Pages: 1-1
- DOI
  10.1080/19490976.2019.1612662
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17997, KAKENHI-PROJECT-18H05280
[Journal Article] Persistent colonization of non-lymphoid tissue-resident macrophages by Stenotrophomonas maltophilia2019
- Author(s)
  Takahashi Ichiro, Hosomi Koji, Nagatake Takahiro, Tobou Hirokazu, Yamamoto Daiki, Hayashi Ikue, Kurashima Yosuke, Sato Shintaro, Shibata Naoko, Goto Yoshiyuki, Maruyama Fumito, Nakagawa Ichiro, Kuwae Asaomi, Abe Akio, Kunisawa Jun, Kiyono Hiroshi
- Journal Title
  
  International Immunology
  
  Volume: 32 Issue: 2 Pages: 133-141
- DOI
  10.1093/intimm/dxz071
- NAID
  120006888456
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07542, KAKENHI-PROJECT-19K10088, KAKENHI-PROJECT-19K22532, KAKENHI-PROJECT-18K17997, KAKENHI-PROJECT-18KK0193, KAKENHI-PROJECT-16H01782, KAKENHI-PROJECT-18H02674, KAKENHI-PROJECT-19H03465, KAKENHI-PROJECT-19H03471, KAKENHI-PROJECT-19H03702, KAKENHI-PROJECT-17K08838, KAKENHI-PROJECT-17K17686, KAKENHI-PROJECT-18H05280, KAKENHI-PROJECT-17J07480, KAKENHI-PROJECT-19H03450
[Journal Article] Development of a bivalent food poisoning vaccine: augmented antigenicity of the C-terminus of Clostridium perfringens enterotoxin by fusion with the B subunit of Escherichia coli Shiga toxin 22018
- Author(s)
  Hosomi Koji、Hinenoya Atsushi、Suzuki Hidehiko、Nagatake Takahiro、Nishino Tomomi、Tojima Yoko、Hirata So-ichiro、Matsunaga Ayu、Kondoh Masuo、Yamasaki Shinji、Kunisawa Jun
- Journal Title
  
  International Immunology
  
  Volume: 31 Issue: 2 Pages: 91-100
- DOI
  10.1093/intimm/dxy071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K17997, KAKENHI-PROJECT-18J00556
[Journal Article] Lymphoid tissue-resident Alcaligenes LPS induces IgA production without excessive inflammatory responses via weak TLR4 agonist activity2018
- Author(s)
  N. Shibata, J. Kunisawa, K. Hosomi, Y. Fujimoto, K. Mizote, N. Kitayama, A. Shimoyama, H. Mimuro, S. Sato, N. 5 Kishishita, K. J. Ishii, K. Fukase, and H. Kiyono
- Journal Title
  
  Mucosal Immunology
  
  Volume: － Issue: 3 Pages: 693-702
- DOI
  10.1038/mi.2017.103
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01914, KAKENHI-PROJECT-16K08836, KAKENHI-PROJECT-26293111, KAKENHI-PUBLICLY-16H01373, KAKENHI-PROJECT-18K17997, KAKENHI-PLANNED-15H05836, KAKENHI-PUBLICLY-18H04620, KAKENHI-PROJECT-16H01885, KAKENHI-PROJECT-18H02674, KAKENHI-PROJECT-18J00556, KAKENHI-PROJECT-17K17686, KAKENHI-PROJECT-17J07480, KAKENHI-PROJECT-18H05280
[Journal Article] Development of Adjuvant-Free Bivalent Food Poisoning Vaccine by Augmenting the Antigenicity of Clostridium perfringens Enterotoxin2018
- Author(s)
  Suzuki Hidehiko、Hosomi Koji、Nasu Ayaka、Kondoh Masuo、Kunisawa Jun
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 9 Pages: 2320-2320
- DOI
  10.3389/fimmu.2018.02320
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K17997, KAKENHI-PROJECT-18J00556
[Journal Article] Immunological association of inducible bronchus-associated lymphoid tissue organogenesis in Ag85B-rHPIV2 vaccine-induced anti-tuberculosis mucosal immune responses in mice.2018
- Author(s)
  Nagatake T, Suzuki H, Hirata S, Matsumoto N, Wada Y, Morimoto S, Nasu A, Shimojou M, Kawano M, Ogami K, Tsujimura Y, Kuroda E, Iijima N, Hosomi K, Ishii KJ, Nosaka T, Yasutomi Y, Kunisawa J.
- Journal Title
  
  Int Immunol
  
  Volume: 30 Issue: 10 Pages: 471-481
- DOI
  10.1093/intimm/dxy046
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19652, KAKENHI-PROJECT-18K17997, KAKENHI-PROJECT-16H05256, KAKENHI-PROJECT-17H04079, KAKENHI-PROJECT-17H04227, KAKENHI-PROJECT-18H02857, KAKENHI-PROJECT-18J00556
[Journal Article] Immunostimulatory effect on dendritic cells of the adjuvant-active exopolysaccharide from Leuconostoc mesenteroides strain NTM0482018
- Author(s)
  Matsuzaki C, Takagaki C, Higashimura Y, Nakashima Y, Hosomi K, Kunisawa J, Yamamoto K, Hisa K.
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 82 Issue: 9 Pages: 1647-1651
- DOI
  10.1080/09168451.2018.1482195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05475, KAKENHI-PROJECT-18K17997, KAKENHI-PROJECT-18J00556
[Presentation] 食・栄養と健康の関わりを細菌学の視点から理解する2023
- Author(s)
  細見晃司
- Organizer
  第96回日本細菌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15004
[Presentation] In vitro樹状細胞を活用したパイエル板組織内共生菌による免疫制御と共生メカニズムの解明2022
- Author(s)
  細見晃司、下山敦史、柴田奈納子、竹山春子、深瀬浩一、清野宏、國澤純
- Organizer
  日本組織培養学会第94回大会
- Data Source
  KAKENHI-PROJECT-22K15004
[Presentation] 腸内細菌Blautiaによる代謝促進を介した肥満・糖尿病の抑制効果2022
- Author(s)
  細見晃司
- Organizer
  レドックスR&D戦略委員会　第2回若手シンポジウム
- Data Source
  KAKENHI-PROJECT-22K15004
[Presentation] Unique carbohydrate and amino acid metabolisms of Blautia wexlerae ameliorate obesity and type 2 diabetes2022
- Author(s)
  Koji Hosomi, et al.
- Organizer
  IHMC 9th Congress 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15004
[Presentation] UNIQUE METABOLISM OF BLAUTIA WEXLERAE HAS BENEFICIAL EFFECTS ON THE CONTROL OF OBESITY AND TYPE 2 DIABETES2022
- Author(s)
  Koji Hosomi, et al.
- Organizer
  9th World Congress on Targeting Microbiota
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15004
[Presentation] Effective and safe adjuvant activity of Alcaligenes LPS and its synthetic lipid A for nasal vaccine.2021
- Author(s)
  Koji Hosomi1, Yunru Wang, Ken Yoshii, Atsushi Shimoyama, Takahiro Nagatake, Azusa Saika, Tomoya Uto, Haruki Yamaura, Davie Kenneth, Yukari Fujimoto, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa
- Organizer
  16th Meeting of the International Endotoxin and Innate Immunity Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17997
[Presentation] A symbiotic mechanism of intestinal lymphoid tissue resident Alcaligenes by controlling metabolic modification in dendritic cells.2021
- Author(s)
  Koji Hosomi, Takahiro Nagatake, Hiroshi Kiyono, Jun Kunisawa
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K17997
[Presentation] パイエル板組織内共生菌アルカリゲネスのリポ多糖の免疫学的特徴を利用したアジュバント開発2021
- Author(s)
  細見晃司、下山敦史、柴田納央子、王韻茹、吉井健、長竹貴広、宇戸智哉、山浦遼生、藤本ゆかり、清野宏、深瀬浩一、國澤純
- Organizer
  第25回日本ワクチン学会学術集会
- Data Source
  KAKENHI-PROJECT-18K17997
[Presentation] 小腸パイエル板組織内共生菌アルカリゲネスと樹状細胞の相互作用2020
- Author(s)
  細見晃司，柴田納央子，下山敦史，宇戸智哉，長竹貴広，東島陽子，西野友美，竹山春子，深瀬浩一，清野宏，國澤純
- Organizer
  腸内細菌学会
- Data Source
  KAKENHI-PROJECT-18K17997
[Presentation] Chemically synthesized Alcaligenes lipid A as a specifically Th17 response-inducing vaccine adjuvant2019
- Author(s)
  Koji Hosomi, Yunru Wang, Ken Yoshii, Atsushi Shimoyama, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa
- Organizer
  ISV 2019 Annual Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17997
[Presentation] Chemically synthesized Alcaligenes lipid A as a new systemic and mucosal vaccine adjuvant2019
- Author(s)
  Koji Hosomi, Atsushi Shimoyama, Wang Yunru, Ken Yoshii, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa
- Organizer
  ASM Microbe 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17997
[Presentation] 小腸パイエル板組織内共生細菌アルカリゲネスの免疫機能とアジュバント応用2019
- Author(s)
  柴田納央子、細見晃司、下山敦史、王韻茹、吉井健、深瀬浩一、清野宏、國澤純
- Organizer
  第15回日本小児消化管感染症研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K17997
[Presentation] Development of a bivalent vaccine for Clostridium perfringens enterotoxin and Escherichia coli Shiga toxin 22018
- Author(s)
  Koji Hosomi and Jun Kunisawa
- Organizer
  2nd Korea-Japan joint meeting on mucosal immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17997
[Presentation] Augmentation of antigenicity of the C-terminal region of Clostridium perfringens enterotoxin by fusion with the B subunit of Escherichia coli Shiga toxin 2 for the development of bivalent food poisoning vaccine2018
- Author(s)
  Koji Hosomi, Atsushi Hinenoya, Hidehiko Suzuki, Takahiro Nagatake, Tomomi Nishino, So-ichiro Hirata, Masuo Kondoh, Shinji Yamasaki, Jun Kunisawa
- Organizer
  International Society for Vaccines
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17997
[Presentation] ウェルシュ菌および志賀毒素産生性大腸菌感染症に対する多価食中毒ワクチンの開発2018
- Author(s)
  細見晃司、日根野谷淳、鈴木英彦、長竹貴広、西野友美、東島陽子、近藤昌夫、山崎伸二、國澤純
- Organizer
  日本ワクチン学会
- Data Source
  KAKENHI-PROJECT-18K17997
[Presentation] Development of a bivalent food poisoning vaccine: augmented antigenicity of C-terminal region of Clostridium perfringensenterotoxin by fusion with Escherichia coli Shiga toxin 2 B subunit2018
- Author(s)
  Hosomi K, Hinenoya A, Suzuki H, Nagatake T, Nishino T, Toshima Y, Kondoh M, Yamasaki S, Kunisawa J
- Organizer
  第16回松山国際学術シンポジウム&若手の会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17997
[]

1. 今村圭文 (90467960)

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Hosomi Koji 細見 晃司

Research Projects

Research Products

Co-Researchers

カンピロバクター感染における自己免疫応答と神経障害の包括的理解と病態解明Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

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乳がん予防を目的とした身体活動基準の策定のための基盤研究

Principal Investigator

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Research Institution

微生物メタボリズムからのカンピロバクター腸炎発症メカニズムの理解Principal Investigator

Principal Investigator

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Review Section

Research Institution

Analysis of the relationship between the gut microbiome and pulmonary non-tuberculous mycobacteriosis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Immune modulation by a symbiotic bacterium Alcaligenes in gut associated lymphoid tissuesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 腸内環境を介した免疫制御とワクチン研究への展開2022

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[Book] ポストバイオティクス研究から考える健康科学の将来と個別化栄養2022

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[Book] 食と腸内細菌から考える健康長寿最前線2022

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[Book] 粘膜面における獲得免疫と感染防御2021

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[Book] 腸内細菌の代謝物を介した免疫機能制御2021

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[Book] 栄養学と腸内細菌から考える個別化医療の将来展望2019

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[Book] 油と腸内フローラから考える健康科学の新展開2019

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[Book] ヒトマイクロバイオームビッグデータと健康医療への応用2018

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[Book] 腸内環境に関連するビッグデータの集積と創薬、機能性食品開発への展望. 腸内細菌叢を標的にした医薬品と保健機能食品の開発2018

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[Journal Article] Alcaligenes lipid A functions as a superior mucosal adjuvant to monophosphoryl lipid A via the recruitment and activation of CD11b+ dendritic cells in nasal tissue2023

Author(s)

Hosomi Koji 細見晃司