YANAGIHARA Katsunori 柳原克紀

… Alternative Names

YANAGIHARA K. 柳原克紀

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Researcher Number	40315239
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Affiliation (Current)	2025: 長崎大学, 医歯薬学総合研究科(医学系), 教授
Affiliation (based on the past Project Information) *help	2015 – 2024: 長崎大学, 医歯薬学総合研究科(医学系), 教授 2011: 長崎大学, 大学院・医歯薬学総合研究科, 准教授 2009 – 2010: Nagasaki University, 病院, 講師 2008: 長崎大学, 長崎大学附属病院, 講師 2006: 長崎大学, 医学部・歯学部付属病院, 講師 … More 2006: Nagasaki University, Laboratory Medicine University Hospital, lecturer, 医学部・歯学部附属病院, 講師 2005: 長崎大学, 大学院・医歯薬学総合研究科, 助手 2002: 長崎大学, 大学院・医歯薬学総合研究科, 助手 2001: 長崎大学, 大学院・薬学研究科, 助手 1999 – 2000: 長崎大学, 医学部・附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 54030:Infectious disease medicine-related / Infectious disease medicine / Respiratory organ internal medicine / Respiratory organ internal medicine Except Principal Investigator Basic Section 52010:General internal medicine-related / Basic Section 54030:Infectious disease medicine-related / Medium-sized Section 58:Society medicine, nursing, and related fields / Basic Section 53030:Respiratory medicine-related / Basic Section 54020:Connective tissue disease and allergy-related / Infectious disease medicine … More / Hygiene and public health / Laboratory medicine / Respiratory organ internal medicine / Applied pharmacology Less
Keywords	Principal Investigator dysbiosis / マイクロバイオーム / SiRNA / 病原因子 / 薬剤耐性菌 / MRSA / 細菌シングルセル解析 / ESBL産生腸内細菌 / ESBL産生菌 / 接合伝達実験 … More / ST131 / ESBL産生細菌 / ESBL / 肺炎桿菌 / 腸内細菌科細菌 / ディスバイオーシス / 腸内細菌叢 / 予防 / 感染症 / 高齢者 / 肺炎 / 気道定着 / 予防法 / 高齢者肺炎 / Pseudomonas aeruginosa / pneumococcus / pathogenesis / gene therapy / respiratory infection / 緑膿菌 / 肺炎球菌 / 遺伝子治療 / 呼吸器感染症 / 遺伝子診断 / 分子疫学解析 / エラスターゼ / オキサゾリジノン / 慢性気道感染症 / 緑膿菌エラスターゼ / マクロライド / バイオフィルム / リネゾリド / VISA / コアグラーゼ … More Except Principal Investigator 遺伝子検査 / HTLV-1 / ATL / 組み込み部位 / 宿主免疫 / 細菌叢 / 薬剤耐性 / 細菌感染 / 病原因子 / therapeutic / drug resistant / Viral hepatitis / Nigeria / drug resistant variant / genotype / incidence / Hepatitis D Virus / Hepatitis C Virus / Hepatitis B Virus / Drug resistance / Genotype / HCV / HDV / HBV / 気管支肺胞洗浄液 / リンパ腫 / 気管支肺胞洗浄 / フローサイトメトリー / クローナリティー / 遺伝子転座 / 分子生物学的手法 / 診断 / 肺リンパ腫 / 人工知能 / 発症予測 / 関節リウマチ / 腸内細菌叢 / 簡易型自記式食事歴法質問票（BDHQ） / 腸内細菌叢解析 / 肺非結核性抗酸菌症 / 組込み部位 / 成人T 細胞白血病 / 成人T細胞白血病 / クロナリティ検査 / 発症クローン / 成人T細胞白血病・リンパ腫（ATL） / NF-kappa B / 感染症 / 起炎菌迅速同定法 / 起因菌 / ATP検査 / 感染症迅速検査 / 細菌数定量 / 迅速起炎菌同定検査 / ATP活性検査 / 細菌数定量検査 / 起炎菌迅速検査 / 迅速起因菌菌数検査 / 迅速起因菌同定定性検査 / NF-κB / ATP測定 / 敗血症バイオマーカー / 敗血症起因菌定量検査 / Tmマッピング法 / 迅速細菌検査 / 敗血症 / オートファジー阻害薬 / オートファジー / 肺炎球菌 / インフルエンザウイルス / 栄養学 / diabetes / malnutrition / tuberculosis / psychosocial health / patient costs / immune function / Nutrition / TB / Psychosocial health / Patient costs / Immune function / Diabetes / Malnutrition / Tuberculosis / バイオマーカー / 遺伝子発現解析 / 表面抗原 / 分子標的 / 細胞株 / Lymphocyte of lung / Cytokine / Macrolide / Pseudomonas aeruginosa / Chronic infection model / 肺内リンパ球 / サイトカイン / マクロライド / 緑膿菌 / 慢性気道感染症モデル / 症例-対照研究 / 肝障害 / 遺伝子診断法 / 相関解析 / 候補遺伝子アプローチ法 / 一塩基多型(SNPs) / 抗酸化関連遺伝子 / 薬物代謝・解毒酵素遺伝子 / 副作用 / 抗結核剤 / ファーマコゲノミクス Less

細菌シングルセル解析を用いた肺炎桿菌感染症の病態解明と革新的制御法の構築Principal Investigator
- Principal Investigator
  
  柳原克紀
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Nagasaki University
多剤耐性菌の制御法の開発に向けた腸内細菌目細菌の環境適応機構の解明
- Principal Investigator
  
  坂本啓
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Yamaguchi University
Molecular epidemiology, antiviral resistant variants and therapeutic options of hepatitis B and C in Nigeria
- Principal Investigator
  
  吉田レイミント
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Nagasaki University
Establishment of a new test method detecting HTLV-1 clonality for capture the onset of ATL
- Principal Investigator
  
  長谷川寛雄
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Nagasaki University
関節炎が起こる前段階で関節リウマチの発症を人工知能で予測する多角的研究
- Principal Investigator
  
  玉井慎美
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Nagasaki University
肺リンパ腫における気管支肺胞洗浄液を用いた内科的診断手法の確立
- Principal Investigator
  
  原敦子
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Nagasaki University
The analysis of microbiota for intestinal colonization of ESBL-producing bacteriaPrincipal Investigator
- Principal Investigator
  
  Yanagihara Katsunori
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Nagasaki University
Analysis of the relationship between the gut microbiome and pulmonary non-tuberculous mycobacteriosis
- Principal Investigator
  
  今村圭文
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Nagasaki University
Construction of a comprehensive sepsis testing system based on the new sepsis definition and its operational deployment in Japan and Southeast Asia.
- Principal Investigator
  
  Kitajima Isao
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  University of Toyama
Establishment of individualized test method for HTLV-1 carriers based on identification and analysis of ATL-onset clones
- Principal Investigator
  
  HASEGAWA Hiroo
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Nagasaki University
Effects of malnutrition and diabetes on treatment outcome and total patient costs in Filipino drug resistant and drug sensitive patients starting anti-TB treatment: A cohort study.
- Principal Investigator
  
  COX Sharon
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene and public health
- Research Institution
  Nagasaki University
Exploration new biomarkers based on HTLV-1 carrier clone analysis
- Principal Investigator
  
  HASEGAWA Hiroo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Nagasaki University
Elucidation of pathological condition of Elderly people pneumonia via analysis of microbiotaPrincipal Investigator
- Principal Investigator
  
  YANAGIHARA Katsunori
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Nagasaki University
The role of autophagy in severe influenza-related pneumonia
- Principal Investigator
  
  KOSAI Kosuke
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Nagasaki University
Molecular characteristic of Community-Acquired methicillin-resistant Staphylococcus aureus isolates by using New Genetic DiagnosisPrincipal Investigator
- Principal Investigator
  
  YANAGIHARA Katsunori
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Nagasaki University
Establishment of DNA-based diagnosis for detecting tuberculosis patients with anti-tuberculosis drug-induced side effects
- Principal Investigator
  
  TSUKAMOTO Kazuhiro
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Nagasaki University
The treatment against respiratory infection -gene therapy with SiRNA-Principal Investigator
- Principal Investigator
  
  YANAGIHARA K.
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nagasaki University
耐性菌感染症に対するアンチセンスヌクレオチドを用いた遺伝子治療Principal Investigator
- Principal Investigator
  
  柳原克紀
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nagasaki University
Analysis of chronic respiratory infection by using a newly established murine model chronic respiratory infection with Pseudomonas aeruginosa-The kinetics of cytokines and analysis of the effect of macrolides-
- Principal Investigator
  
  KOHNO Shigeru
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nagasaki University

[Book] マイクロバイオームと感染症研究の進歩2018
- Author(s)
  栁原克紀
- Total Pages
  606
- Publisher
  最新医学社
- Data Source
  KAKENHI-PROJECT-15K09572
[Book] 人工呼吸2018
- Author(s)
  賀来　敬仁、栁原　克紀
- Total Pages
  6
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-15K09572
[Book] Drug Delivery Sysstem2018
- Author(s)
  賀来　敬仁、栁原　克紀
- Total Pages
  7
- Publisher
  日本DDS学会
- Data Source
  KAKENHI-PROJECT-15K09572
[Book] 「高齢者疾患とマイクロバイオーム」高齢者肺炎とマイクロバイオーム、2017
- Author(s)
  賀来敬仁、栁原克紀、
- Total Pages
  4
- Publisher
  THE LUNG perspectives
- Data Source
  KAKENHI-PROJECT-15K09572
[Book] 医療スタッフのための微生物検査のススメ2017
- Author(s)
  柳原克紀編
- Total Pages
  180
- Publisher
  ヴァンメディカル
- Data Source
  KAKENHI-PROJECT-15K09572
[Journal Article] The clinical characteristics and molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) among very elderly people in Japan.2023
- Author(s)
  Mitsumoto-Kaseida F, Morinaga Y, Sasaki D, Ota K, Kaku N, Sakamoto K, Kosai K, Hasegawa H, Hayashi J, Yanagihara K.
- Journal Title
  
  Geriatr Gerontol Int
  
  Volume: 23 Issue: 10 Pages: 744-749
- DOI
  10.1111/ggi.14664
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K07923
[Journal Article] Clinical and microbiological characteristics of bloodstream infection caused by Klebsiella pneumoniae harboring rmpA in Japanese adults.2023
- Author(s)
  Kikuchi S, Kosai K, Ota K, Mitsumoto-Kaseida F, Sakamoto K, Hasegawa H, Izumikawa K, Mukae H, Yanagihara K.
- Journal Title
  
  Sci Rep.
  
  Volume: 13 Issue: 1 Pages: 6571-6571
- DOI
  10.1038/s41598-023-33265-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K07923, KAKENHI-PROJECT-20K08843
[Journal Article] Serological response to a third dose of SARS-CoV-2 vaccine according to previous infection history2023
- Author(s)
  Ota Kenji、Murakami Satoshi、Ishihara Kaori、Sasaki Daisuke、Usui Tetsuya、Mitsumoto-Kaseida Fujiko、Sakamoto Ke、Mukae Hiroshi、Kohno Shigeru、Yanagihara Katsunori
- Journal Title
  
  Vaccine: X
  
  Volume: 13 Pages: 100282-100282
- DOI
  10.1016/j.jvacx.2023.100282
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08842, KAKENHI-PROJECT-21K16323, KAKENHI-PROJECT-23K07923
[Journal Article] Epidemiological analysis and antimicrobial susceptibility profile of Gram-negative bacilli that cause bacteremia in Japan2023
- Author(s)
  Kosai Kosuke、Yamagishi Yuka、Mikamo Hiroshige、Ishii Yoshikazu、Tateda Kazuhiro、Yanagihara Katsunori
- Journal Title
  
  Journal of Infection and Chemotherapy
  
  Volume: 29 Issue: 12 Pages: 1091-1096
- DOI
  10.1016/j.jiac.2023.08.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08843
[Journal Article] The evaluation of a rapid microfluidic immunofluorescence antigen test in detecting the infectiousness of COVID-19 patients.2023
- Author(s)
  Ota K, Kodama H, Kawamoto Y, Sasaki D, Mitsumoto-Kaseida F, Sakamoto K, Kosai K, Hasegawa H, Takazono T, Izumikawa K, Mukae H, Tun MMN, Morita K, Yanagihara K.
- Journal Title
  
  BMC Infect Dis.
  
  Volume: 23 Issue: 1 Pages: 823-823
- DOI
  10.1186/s12879-023-08821-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K07923
[Journal Article] Diagnostic Performance of BD Phoenix CPO Detect Panels for Detection and Classification of Carbapenemase-Producing Gram-Negative Bacteria2023
- Author(s)
  Murata Mika、Kosai Kosuke、Akamatsu Norihiko、Matsuyama Yumiko、Oda Mitsuharu、Wakamatsu Atsushi、Izumikawa Koichi、Mukae Hiroshi、Yanagihara Katsunori
- Journal Title
  
  Microbiology Spectrum
  
  Volume: 11 Issue: 3
- DOI
  10.1128/spectrum.00897-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08843
[Journal Article] Performance of the GeneSoC Rapid PCR System in Detection of SARS-CoV-2 from Saliva Specimens2023
- Author(s)
  Ota Kenji、Kurahara Ryo、Tsukamoto Chie、Kawamoto Yasuhide、Akamatsu Norihiko、Sasaki Daisuke、Mitsumoto-Kaseida Fujiko、Sakamoto Kei、Kosai Kosuke、Hasegawa Hiroo、Yamamoto Kazuko、Izumikawa Koichi、Mukae Hiroshi、Yanagihara Katsunori
- Journal Title
  
  Microbiology Spectrum
  
  Volume: 11 Issue: 2 Pages: 1-3
- DOI
  10.1128/spectrum.03259-22
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08842, KAKENHI-PROJECT-21K16323, KAKENHI-PROJECT-23K07923
[Journal Article] Escherichia coli ST131 isolated from urological patients can acquire plasmid-mediated extended spectrum β-lactamase from other bacteria with high frequency2022
- Author(s)
  Kondo T, Sakamoto K, Morinaga Y, Miyata Y, Yanagihara K, Sakai H.
- Journal Title
  
  Int J Urol.
  
  Volume: - Issue: 6 Pages: 587-594
- DOI
  10.1111/iju.14845
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08842, KAKENHI-PROJECT-20K08843
[Journal Article] Pulmonary nodular lymphoid hyperplasia evaluated with bronchoalveolar lavage fluid findings: A case report and review of literature on Japanese patients Internal medicine.2022
- Author(s)
  Moriyama S, Kido, Sakamoto N, Fuchigami M, Tokito T, Okuno D, Miyamura T, Nakashima S, Hara A, Ishimoto H, Imaizumi Y, Tsuruda K, Yanagihara K, Fukuoka J, Mukae H.
- Journal Title
  
  Internal Medicine
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08156
[Journal Article] TAS‐116 (pimitespib), a heat shock protein 90 inhibitor, shows efficacy in preclinical models of adult T‐cell leukemia2021
- Author(s)
  Ikebe Emi、Shimosaki Shunsuke、Hasegawa Hiroo、Iha Hidekatsu、Tsukamoto Yoshiyuki、Wang Yu、Sasaki Daisuke、Imaizumi Yoshitaka、Miyazaki Yasushi、Yanagihara Katsunori、Hamaguchi Isao、Morishita Kazuhiro
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 2 Pages: 684-696
- DOI
  10.1111/cas.15204
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-20K17390, KAKENHI-PROJECT-23K21375
[Journal Article] Serotype distribution and antimicrobial susceptibility of Streptococcus pneumoniae associated with invasive pneumococcal disease among adults in Japan2021
- Author(s)
  Yanagihara Katsunori、Kosai Kosuke、Mikamo Hiroshige、Mukae Hiroshi、Takesue Yoshio、Abe Machiko、Taniguchi Kazuko、Petigara Tanaz、Kaku Mitsuo
- Journal Title
  
  International Journal of Infectious Diseases
  
  Volume: 102 Pages: 260-268
- DOI
  10.1016/j.ijid.2020.10.017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02728
[Journal Article] The global dissemination of hospital clones of Enterococcus faecium2021
- Author(s)
  van Hal Sebastiaan J.、Enterococcal Group、Willems Rob J. L.、Gouliouris Theodore、Ballard Susan A.、Coque Teresa M.、Hammerum Anette M.、Hegstad Kristin、Westh Hendrik T.、Howden Benjamin P.、Malhotra-Kumar Surbhi、Werner Guido、Yanagihara Katsunori、Earl Ashlee M.、Raven Katherine E.、Corander Jukka、Bowden Rory
- Journal Title
  
  Genome Medicine
  
  Volume: 13 Issue: 1
- DOI
  10.1186/s13073-021-00868-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02728
[Journal Article] Tocilizumab has no direct effect on cell lines infected with human T-cell　leukemia virus type 1.2021
- Author(s)
  Endo Y, Fukui S, Koga T, Sasaki D, Hasegawa H, Yanagihara K, Okayama A, Nakamura T, Kawakami A, Nakamura H. Tocilizumab has no direct effect on cell lines infected with human T-cell　leukemia virus type 1.
- Journal Title
  
  J Int Med Res.
  
  Volume: 49 Issue: 3 Pages: 1-10
- DOI
  10.1177/03000605211002083
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08884, KAKENHI-PROJECT-19K08886, KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-19K17888
[Journal Article] Evaluation of a novel rapid TRC assay for the detection of influenza using nasopharyngeal swabs and gargle samples2021
- Author(s)
  Kaku N, Hashiguchi K, Akamatsu N, Wakigawa F, Matsuda J, Komaru K, Nakao T, Harada Y, Hara A, Uno N, Sakamoto K, Morinaga Y, Kitazaki T, Hasegawa H, Miyazaki T, Fukuda M, Izumikawa K, Mukae H, Yanagihara K.
- Journal Title
  
  Eur J Clin Microbiol Infect Dis
  
  Volume: - Issue: 8 Pages: 1743-1748
- DOI
  10.1007/s10096-021-04193-7
- NAID
  120007000285
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08842, KAKENHI-PROJECT-18H02728
[Journal Article] Flow cytometry assay for the detection of single-copy DNA in human lymphocytes2020
- Author(s)
  Uno Naoki、Kaku Norihito、Morinaga Yoshitomo、Hasegawa Hiroo、Yanagihara Katsunori
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 48 Issue: 15 Pages: e86-e86
- DOI
  10.1093/nar/gkaa515
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02728, KAKENHI-PROJECT-18H02733
[Journal Article] HTLV-1 targets human placental trophoblasts in seropositive pregnant women2020
- Author(s)
  Tezuka Kenta、Fuchi Naoki、Okuma Kazu、Tsukiyama Takashi、Miura Shoko、Hasegawa Yuri、Nagata Ai、Komatsu Nahoko、Hasegawa Hiroo、Sasaki Daisuke、Sasaki Eita、Mizukami Takuo、Kuramitsu Madoka、Matsuoka Sahoko、Yanagihara Katsunori、Miura Kiyonori、Hamaguchi Isao
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 130 Issue: 11 Pages: 6171-6186
- DOI
  10.1172/jci135525
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09265, KAKENHI-PROJECT-20K07670, KAKENHI-PROJECT-18K16805, KAKENHI-PROJECT-19K16032, KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-17K11241, KAKENHI-PROJECT-18K08378
[Journal Article] Treatment of severe pneumonia by hinokitiol in a murine antimicrobial-resistant pneumococcal pneumonia model2020
- Author(s)
  Isono Toshihito、Domon Hisanori、Nagai Kosuke、Maekawa Tomoki、Tamura Hikaru、Hiyoshi Takumi、Yanagihara Katsunori、Kunitomo Eiji、Takenaka Shoji、Noiri Yuichiro、Terao Yutaka
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 10 Pages: e0240329-e0240329
- DOI
  10.1371/journal.pone.0240329
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09903, KAKENHI-PROJECT-18H02728, KAKENHI-PROJECT-19H03828, KAKENHI-PROJECT-20J15490, KAKENHI-PROJECT-19K22706
[Journal Article] A Methodology for Assessing Tumor Clonality of Adult T Cell Leukemia/Lymphoma2020
- Author(s)
  Yamakawa T, Uno N, Sasaki D, Kaku N, Sakamoto K, Kosai K, Hasegawa H, Miyazaki Y, Yanagihara K.
- Journal Title
  
  Mol Ther Methods Clin Dev.
  
  Volume: 19 Pages: 463-473
- DOI
  10.1016/j.omtm.2020.10.015
- NAID
  120006980751
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08842, KAKENHI-PROJECT-18H02733
[Journal Article] Discrepancies in preferences regarding the care of terminal-phase pneumonia in elderly patients among patients, families, and doctors: A multicenter questionnaire survey in nagasaki, Japan2020
- Author(s)
  Takazono Takahiro、Imamura Yoshifumi、Kawakami Kaoru、Yamasaki Naoya、Shimizu Hiroyoshi、Usuki Katsuhiro、Kiyohara Maiko、Hirayama Tatsuro、Tashiro Masato、Hosogaya Naoki、Saijo Tomomi、Yamamoto Kazuko、Miyazaki Taiga、Yanagihara Katsunori、Izumikawa Koichi、Mukae Hiroshi
- Journal Title
  
  Respiratory Investigation
  
  Volume: 58 Issue: 6 Pages: 488-494
- DOI
  10.1016/j.resinv.2020.05.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02728
[Journal Article] Multicenter surveillance of the epidemiology of gram-negative bacteremia in Japan2020
- Author(s)
  Kosai Kosuke、Yamagishi Yuka、Hashinaga Kazuhiko、Nakajima Kazuhiko、Mikamo Hiroshige、Hiramatsu Kazufumi、Takesue Yoshio、Yanagihara Katsunori
- Journal Title
  
  Journal of Infection and Chemotherapy
  
  Volume: 26 Issue: 3 Pages: 193-198
- DOI
  10.1016/j.jiac.2019.11.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02728
[Journal Article] A high-throughput detection method for the clonality of Human T-cell leukemia virus type-1-infected cells in vivo2020
- Author(s)
  Saito M, Hasegawa H, Yamauchi S, Nakagawa S, Sasaki D, Nao N, Tanio M, Wada Y, Matsudaira T, Momose H, Kuramitsu M, Yamagishi M, Nakashima M, Nakahata S, Iha H, Ogata M, Imaizumi Y, Uchimaru K, Morishita K, Watanabe T, Miyazaki Y, Yanagihara K.
- Journal Title
  
  Int J Hematol.
  
  Volume: 112 Issue: 3 Pages: 300-306
- DOI
  10.1007/s12185-020-02935-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08868, KAKENHI-PROJECT-20K07670, KAKENHI-PROJECT-17H03594, KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-19H03575, KAKENHI-PROJECT-18K08317, KAKENHI-PROJECT-19K16580, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06277
[Journal Article] The Effect of In Vitro Hemolysis on Measurement of Cell-Free DNA2019
- Author(s)
  Nishimura F, Uno N, Chiang PC, Kaku N, Morinaga Y, Hasegawa H, Yanagihara K
- Journal Title
  
  J Appl Lab Med
  
  Volume: 4(2) Issue: 2 Pages: 235-240
- DOI
  10.1373/jalm.2018.027953
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08986, KAKENHI-PROJECT-18H02733
[Journal Article] Nationwide surveillance of bacterial respiratory pathogens conducted by the surceillance committee of Japanese Society of Chemoterapy, the Japanese association for Infectious Diseases, and the Japanese Society for clinical microbiology in 2014: General view of pathogens' antibacterial susceptibity.2019
- Author(s)
  Yanagihara K, Matumoto T, Aoki N, Sato J, Wakamura T, Kiyota H, et al.
- Journal Title
  
  J.Infect Chemother
  
  Volume: 25(9) Issue: 9 Pages: 657-668
- DOI
  10.1016/j.jiac.2019.05.006
- Data Source
  KAKENHI-PROJECT-18H02728
[Journal Article] The role of molecular diagnosis in acute respiratory tract infection.2019
- Author(s)
  Yanagihara K
- Journal Title
  
  Repir. Investig.
  
  Volume: 57(6) Issue: 6 Pages: 511-511
- DOI
  10.1016/j.resinv.2019.06.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02728
[Journal Article] Oligosecretory Primary Plasma Cell Leukemia with Atypical Morphological Abnormality2019
- Author(s)
  Toriyama E, Imaizumi Y, Tsuruda K, Itonaga H, Sato S, Ando K, Sawayama Y, Hasegawa H, Hata T, Niino D, Yanagihara K, Miyazaki Y
- Journal Title
  
  Intern. Med.
  
  Volume: 58 Issue: 15 Pages: 2213-2217
- DOI
  10.2169/internalmedicine.2472-18
- NAID
  130007686846
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2019-08-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10050, KAKENHI-PROJECT-17K16189, KAKENHI-PROJECT-18K16121, KAKENHI-PROJECT-18H02733
[Journal Article] Molecular epidemiology of Clostridioides difficile and risk factors for the detection of toxin gene-positive strains.2019
- Author(s)
  Okada Y, Kaku N, Kosai K, Uno N, Morinaga Y, Hasegawa H, Yanagihara K.
- Journal Title
  
  J Infect Chemother
  
  Volume: 4 Issue: 4 Pages: 262-266
- DOI
  10.1016/j.jiac.2018.12.004
- NAID
  120007000280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09572
[Journal Article] Exploring the microbiota of upper respiratory tract during the development of pneumonia in a mouse model2019
- Author(s)
  Morinaga Y, Take Y, Sasaki D, Ota K, Kaku N, Uno N, Sakamoto K, Kosai K, Miyazaki T, Hasegawa H, Izumikawa K, Mukae H, Yanagihara K
- Journal Title
  
  PLoS One
  
  Volume: 14(9) Issue: 9 Pages: e0222589-e0222589
- DOI
  10.1371/journal.pone.0222589
- NAID
  120006988400
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02733
[Journal Article] Risk Factors for Acquisition of Fluoroquinolone or Aminoglycoside Resistance in Addition to Carbapenem Resistance in Pseudomonas aeruginosa.2018
- Author(s)
  Kosai K, Kaku N, Uno N, Saijo T, Morinaga Y, Imamura Y, Hasegawa H, Miyazaki T, Izumikawa K, Mukae H, Yanagihara K.
- Journal Title
  
  Open Microbiol J
  
  Volume: 12 Pages: 321-322
- NAID
  120006987429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09572
[Journal Article] Performance evaluation of the MALDI Biotyper Selective Testing of Antibiotic Resistance-β-Lactamase (MBT STAR-BL) assay for the detection of IMP metallo-β-lactamase activity in Enterobacteriaceae.2018
- Author(s)
  Kawamoto Y, Kosai K, Yamakawa H, Kaku N, Uno N, Morinaga Y, Hasegawa H, Miyazaki T, Izumikawa K, Mukae H, Yanagihara K.
- Journal Title
  
  Diagn Microbiol Infect Dis
  
  Volume: 92 Pages: 275-278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09572
[Journal Article] Evaluation of FilmArray respiratory panel multiplex polymerase chain reaction assay for detection of pathogens in adult outpatients with acute respiratory tract infection.2018
- Author(s)
  Kaku N, Hashiguchi K, Iwanaga Y, Akamatsu N, Matsuda J, Kosai K, Uno N, Morinaga Y, Kitazaki T, Hasegawa H, Miyazaki T, Fukuda M, Izumikawa K, Mukae H, Yanagihara K.
- Journal Title
  
  J Infect Chemother.
  
  Volume: 9 Issue: 9 Pages: 734-738
- DOI
  10.1016/j.jiac.2018.05.006
- NAID
  120007000279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09572
[Journal Article] Natural course of HTLV-1 proviral DNA levels in carriers during pregnancy2018
- Author(s)
  Fuchi N, Miura K, Tsukiyama T, Sasaki D, Ishihara K, Tsuruda K, Hasegawa H, Miura S, Yanagihara K, Masuzaki H
- Journal Title
  
  Journal of Infectious Diseases
  
  Volume: 217 Issue: 9 Pages: 1383-1389
- DOI
  10.1093/infdis/jiy017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11241, KAKENHI-PROJECT-16K20198, KAKENHI-PROJECT-17K11283, KAKENHI-PROJECT-18K09265, KAKENHI-PROJECT-18K16805, KAKENHI-PROJECT-18H02733
[Journal Article] Diversity of cell phenotypes among MT-2 cell lines affects the growth of U937 cells and cytokine production2018
- Author(s)
  Nomura Hajime、Umekita Kunihiko、Hashikura Yuuki、Umeki Kazumi、Yamamoto Ikuo、Aratake Yatsuki、Saito Mineki、Hasegawa Hiroo、Yanagihara Katsunori、Okayama Akihiko
- Journal Title
  
  Human Cell
  
  Volume: 32 Issue: 2 Pages: 185-192
- DOI
  10.1007/s13577-018-00231-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-18K07541
[Journal Article] In Vitro Activity of Lascufloxacin against Streptococcus pneumoniae with Mutations in the Quinolone Resistance-Determining Regions2018
- Author(s)
  Murata M, Kosai K, Yamauchi S, Sasaki D, Kaku N, Uno N, Morinaga Y, Hasegawa H, Miyazaki T, Izumikawa K, Mukae H, Yanagihara K
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 62
- NAID
  120006988021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09572
[Journal Article] Fluoroquinolone resistance in extended-spectrum β-lactamase-producing Klebsiella pneumoniae in a Japanese tertiary hospital: silent shifting to CTX-M-15-producing K. pneumoniae.2017
- Author(s)
  Higashino M, Murata M, Morinaga Y, Akamatsu N, Matsuda J, Takeda K, Kaku N, Kosai K, Uno N, Hasegawa H, Yanagihara K.
- Journal Title
  
  Journal of Medical Microbiology.
  
  Volume: 66 Issue: 10 Pages: 1476-82
- DOI
  10.1099/jmm.0.000577
- NAID
  120006987383
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09572
[Journal Article] Detection of Fusobacterium nucleatum in two cases of empyema and lung abscess using paromomycin-vancomycin supplemented Brucella HK agar.2017
- Author(s)
  Nagaoka K, Yanagihara K, Morinaga Y, Kohno S.
- Journal Title
  
  Anaerobe.
  
  Volume: 43 Pages: 99-101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09572
[Journal Article] Infection of defective human T-lymphotropic virus type 12017
- Author(s)
  Hashikura Yuuki、Umeki Kazumi、Umekita Kunihiko、Nomura Hajime、Yamada Akiteru、Yamamoto Ikuo、Hasegawa Hiroo、Yanagihara Katsunori、Okayama Akihiko
- Journal Title
  
  Human Cell
  
  Volume: 30 Issue: 2 Pages: 117-123
- DOI
  10.1007/s13577-016-0156-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08647
[Journal Article] Performance evaluation of the Verigene®Clostridium difficile nucleic acid test, an automated multiplex molecular testing system for detection of C. difficile toxin.2017
- Author(s)
  Kosai K, Iwanaga Y, Akamatsu N, Okada Y, Kaku N, Uno N, Morinaga Y, Hasegawa H, Miyazaki T, Izumikawa K, Mukae H, Yanagihara K.
- Journal Title
  
  J Infect Chemother
  
  Volume: 23 Issue: 10 Pages: 674-677
- DOI
  10.1016/j.jiac.2017.07.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09572, KAKENHI-PROJECT-16K09936
[Journal Article] Tumor necrosis factor alpha inhibitors have no effect on a human T-lymphotropic virus type-I (HTLV-I)-infected cell line from patients with HTLV-I-associated myelopathy.2017
- Author(s)
  Fukui S, Nakamura H, Takahashi Y, Iwamoto N, Hasegawa H, Yanagihara K, Nakamura T, Okayama A, Kawakami A.
- Journal Title
  
  BMC Immunol.
  
  Volume: 18 Issue: 1 Pages: 1-10
- DOI
  10.1186/s12865-017-0191-2
- NAID
  120006987561
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19605, KAKENHI-PROJECT-15K08647
[Journal Article] Clinical application of a ligation-independent pathway of multiplex ligation-dependent probe amplification for the determination of quinolone susceptibility of Streptococcus pneumoniae.2016
- Author(s)
  Uno N, Araki N, Kaku N, Kosai K, Hasegawa H, Yanagihara K.
- Journal Title
  
  J Microbiol Methods
  
  Volume: 128 Pages: 13-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09572
[Journal Article] Induction of apoptosis by HBI-8000 in adult T-cell leukemia/lymphoma is associated with activation of Bim and NLRP3.2016
- Author(s)
  Hasegawa H, Bissonnette RP, Gillings M, Sasaki D, Taniguchi H, Kitanosono H, Tsuruda K, Kosai K, Uno N, Morinaga Y, Imaizumi Y, Miyazaki Y, Yanagihara K.
- Journal Title
  
  Cancer Sci
  
  Volume: 107 Issue: 8 Pages: 1124-33
- DOI
  10.1111/cas.12971
- NAID
  120006987664
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08647
[Journal Article] Premedication with clarithromycin is effective against secondary bacterial pneumonia during influenza virus infection in a pulmonary emphysema mouse model.2016
- Author(s)
  Harada T, Ishimatsu Y, Hara A, Morita T, Nakashima S, Kakugawa T, Sakamoto N, Kosai Y, Izumikawa K, Yanagihara K, Mukae H, Kohno S
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 358 Issue: 3 Pages: 457-463
- DOI
  10.1124/jpet.116.233932
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09936, KAKENHI-PROJECT-15K19587
[Journal Article] Quantitative RT-PCR evaluation of a rapid influenza antigen test for efficient diagnosis of influenza virus infection.2015
- Author(s)
  Ｔsushima Y, Uno N, Sasaki D, Morinaga Y, Hasegawa H, Yanagihara K:
- Journal Title
  
  J Virol Methods
  
  Volume: 212 Pages: 76-9
- NAID
  120006987121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09572
[Journal Article] 感染症迅速診断―これからの可能性―2015
- Author(s)
  栁原克紀
- Journal Title
  
  感染症
  
  Volume: 45 Pages: 123-130
- Data Source
  KAKENHI-PROJECT-15K09572
[Journal Article] Multicenter evaluation of the Verigene Gram-negative blood culture nucleic acid test for rapid detection of bacteria and resistance determinants in positive blood cultures2015
- Author(s)
  Uno N, Suzuki H, Yamakawa H, Yamada M, Yaguchi Y, Notake S, Tamai K, Yanagisawa H, Misawa S, Yanagihara K.
- Journal Title
  
  Diagn Microbiol Infect Dis
  
  Volume: 83 Pages: 344-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09572
[Journal Article] Antimicrobial susceptibility and molecular characteristic of 857 methicillin-resistant Staphylococcus aureus isolates from 16 medical centers in Japan(2008-2009): Nationwide survey of community-acquired and nosocomial MRSA2012
- Author(s)
  Yanagihara K, Araki N, Watanabe S, Kinebuchi T, Kaku M, Maesakii S, Yamaguchi K, Matsumoto, Mikamo H, Takesue Y, Fujita J, Kadota J, Iwatsuki K, Hino H, Kaneko T, Asagoe K, Ikeda M, T Yasuoka A, Kohno S
- Journal Title
  
  Diagn Microbiol Infect Dis
  
  Volume: 72 Pages: 253-257
- Data Source
  KAKENHI-PROJECT-21591294
[Journal Article] Antimicrobial susceptibility and molecular characteristic of 857 methicillin-resistant Staphylococcus aureus isolates from 16 medical centers in Japan (2008-2009) : Nationwide survey of community-acquired and nosocomial MRSA2012
- Author(s)
  Yanagihara K, et.al
- Journal Title
  
  Diagn Microbiol Infect Dis
  
  Volume: 72 Pages: 253-257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591294
[Journal Article] High dose tobramycin inhibits lipopolysaccharide-induced MUC5AC production in human lung epithelial cells2011
- Author(s)
  Nakamura S, Yanagihara K, Araki N, Morinaga Y, Yamada, K, Izumikawa K, Seki M, Kakeya H, Yamamoto Y, Kamihira S, Kohno
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 659 Pages: 67-71
- NAID
  120006985129
- Data Source
  KAKENHI-PROJECT-21591294
[Journal Article] High dose tobramycin inhibits lipopolysaccharide-induced MUC5AC production in human lung epithelial cells. European Journal of Pharmacology2011
- Author(s)
  Nakamura S, Yanagihara K, et.al
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 659 Pages: 67-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591294
[Journal Article] Clinical characteristics of bacteremia caused by methicillin-resistant Staphylococcus aureus in a tertiary hospital2011
- Author(s)
  Yamada K, Yanagihara K, Hara Y, Araki N, Harada Y, Morinaga Y, Matsuda J, Izumikawa K, Seki M, Kakeya H, Yamamoto Y, Kohno S, Kamihira S
- Journal Title
  
  Tohoku J Exp Med
  
  Volume: 224 Pages: 61-67
- Data Source
  KAKENHI-PROJECT-21591294
[Journal Article] Clinical characteristics of bacteremia caused by methicillin-resistant Staphylococcus aureus in a tertiary hospital2011
- Author(s)
  Yamada K, Yanagihara K, et.al
- Journal Title
  
  Tohoku J Exp Med
  
  Volume: 242 Pages: 61-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591294
[Journal Article] Azithromycin inhibits nontypeable Haemophilus infuenzae-induced MUC5AC expression and secretion via inhibition of activator protein -1 in human airway epithelial cells2010
- Author(s)
  Araki N, Yanagihara, et al
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 644 Pages: 209-214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591294
[Journal Article] Evaluation of Pathogen Detection from Clinical Samples by Real-Time PCR using a Sepsis Pathogen, DNA Detection Kit.2010
- Author(s)
  Yanagihara K, et al
- Journal Title
  
  Critical Care.
  
  Volume: 14(4)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591294
[Journal Article] Evaluation of pathogen detection from clinical samples by real-time polymerase chain reaction using a sepsis pathogen DNA detection Kit2010
- Author(s)
  Yanagihara K, Kitagawa Y, Tomonaga M, Tsukasaki K, Kohno S, Seki M, Sugimoto H, Shimazu T, Tasaki O, Matsushima A, Ikeda Y, Okamoto S, Aikawa N, Hori S, Obara H, Ishizaka A, Hasegawa N, Takeda J, Kamihira S, Sugahara K, Asari S, Murata M, Kobayashi Y, Gin
- Journal Title
  
  Critical Care
  
  Volume: 14
- Data Source
  KAKENHI-PROJECT-21591294
[Journal Article] Genetic diagnosis of community-acquired MRSA : A multiplex real-time PCR method for staphylococcal cassette chromosome mec typing and detecting toxin genes2010
- Author(s)
  Motoshima M, Yanagihara K, Morinaga Y, Matsuda J, Sugahara K, Yamada Y, Kohno S, Kamihira S
- Journal Title
  
  Tohoku J Exp Med
  
  Volume: 220 Pages: 165-170
- NAID
  10027083430
- Data Source
  KAKENHI-PROJECT-21591294
[Journal Article] Efficacy of linezolid against PVL-positive MRSA in a mouse model of hematogenous pulmonary infection2009
- Author(s)
  Yanagihara K, et.al
- Journal Title
  
  Int J Antimicrob Agents 34
  
  Pages: 477-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591294
[Journal Article] Efficacy of linezolid against PVL-positive MRSA in a mouse model of hematogenous pulmonary infection2009
- Author(s)
  Yanagihara K, Kihara R, Araki N, Morinaga Y, Seki M, Izumikawa K, Kakeya H, Yamamoto Y, Yamada Y, Kamihira S, Tsukamoto K, Kohno S
- Journal Title
  
  Int J Antimicrob Agents
  
  Volume: 34 Pages: 477-481
- Data Source
  KAKENHI-PROJECT-21591294
[Journal Article] Effects of specific neutrophil elastase inhibitor, sivelestat sodium hydrate, in murine model of severe pneumococcal pneumonia.2007
- Author(s)
  Yanagihara K., et al.
- Journal Title
  
  Experimental Lung Research 33巻2号
  
  Pages: 71-80
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590796
[Journal Article] A haplotype,NAT2^+6A,of the N-acetyltransferase 2 gene is an important for a risk of anti-tuberculosis drug-induced hepatotoxicity in japanese patients with tuberculosis2007
- Author(s)
  Higuchi N, Tahara N, Yanagihara K, Kohno S, Tsukamoto K, et al.
- Journal Title
  
  World Journal of Gastroenterology, (in press)
- Data Source
  KAKENHI-PROJECT-18390168
[Journal Article] Effects of specific neutrophil elastase inhibitor, sivelestat sodium hydrate, in murine model of severe pneumococcal pneumonia.2007
- Author(s)
  Katsunori Yanagihara et al.
- Journal Title
  
  Experimental Lung Research 33(2)
  
  Pages: 71-80
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590796
[Journal Article] Telithromycin inhibits the number of viable bacteria but not lymphocytes accumulation in murine model of chronic respiratory infection2007
- Author(s)
  Yanagihara K., et al.
- Journal Title
  
  Chemotherapy 53巻
  
  Pages: 10-13
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590796
[Journal Article] A haplotype, NAT2*6A, of the il, acetyltransferase 2 gene is an important biomarker for a risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis2007
- Author(s)
  Higuchi N, Tahara N, Yanagihara K, Fukushima K, Suyama N, Inoue Y, Miyazaki Y, Kobayashi T, Yoshiura K, Niikawa N, Wen C-Y, Isomoto H, ShikuwaS, MizutaY, Kohno S, Tsukamoto K
- Journal Title
  
  World Gastroenterol 13(45)
  
  Pages: 6003-6008
- Data Source
  KAKENHI-PROJECT-18390168
[Journal Article] A haplotype, NAT2*6A, of the N-acetyltransferase 2 gene is an important biomarker for a risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis2007
- Author(s)
  Higuchi N, Tahara N, Yanagihara K, Kohno S, Tsukamoto K, et. al.
- Journal Title
  
  World Journal of Gastroenterology 13(45)
  
  Pages: 6003-6008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390168
[Journal Article] Effect of anti-PcrV Antibody in Murine Chronic Airway Pseudomonas aeruginosa Infection Model2007
- Author(s)
  Imamura Y, Yanagihara K., et al.
- Journal Title
  
  European Respiratory Journal 54(In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590796
[Journal Article] Effects of anti-PcrV Antibody in Murine Chronic Airway Pseudomonas aeruginosa Infection Model2007
- Author(s)
  Imamura Y, Yanagihara K, et al.
- Journal Title
  
  European Repiratory Journal 29巻(In press)
- Data Source
  KAKENHI-PROJECT-17590796
[Journal Article] In vivo efficacies and pharmacokinetics of DX-619, a novel des-fluoro(6) quinolone, against Streptococcus pneumoniae in a mouse lung infection model.2006
- Author(s)
  Fukuda Y, Yanagihara K., et al.
- Journal Title
  
  Antimicrobial Agents and Chemotherapy. 50
  
  Pages: 121-125
- Data Source
  KAKENHI-PROJECT-17590796
[Journal Article] Effects of short interfering RNA against methicillin-resistant Staphylococcus aureus coagulase in vitro and in vivo.2006
- Author(s)
  Yanagihara K., et al.
- Journal Title
  
  Journal of Antimicrobial Chemotherapy 57
  
  Pages: 122-126
- Data Source
  KAKENHI-PROJECT-17590796
[Journal Article] Effects of macrolides against pneumolysin of macrolide-resistant Streptococcus pneumoniae2006
- Author(s)
  Fukuda Y, Yanagihara K, et al.
- Journal Title
  
  European Repiratory Journal 27巻5号
  
  Pages: 1020-5
- Data Source
  KAKENHI-PROJECT-17590796
[Journal Article] Role of Pseudomonas aeruginosa quorum-sensing systems in a mouse model of chronic respiratory infection.2005
- Author(s)
  Imamura Y, Yanagihara K., et al.
- Journal Title
  
  Journal of Medical Microbiology 54
  
  Pages: 515-518
- Data Source
  KAKENHI-PROJECT-17590796
[Presentation] 肺リンパ腫のBALFを用いた分子生物学的診断法の確立2023
- Author(s)
  城戸　貴志、原　敦子、坂本　憲穂、加藤　丈晴、渕上　麻衣、山内　俊輔、時任　高諄、奥野　大輔、由良　博一、石本　裕士、今泉　芳孝、尾長谷　靖、石松　祐二、栁原　克紀、迎　寛
- Organizer
  第63回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K08156
[Presentation] 長崎県HTLV-1母子感染防止事業の結果解析2023
- Author(s)
  加勢田富士子, 小佐井康介, 柳原克紀, 吉田麻衣子, 臼井哲也, 佐々木大介, 長谷川寛雄, 三浦清徳
- Organizer
  第38回日本環境感染学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-23K24233
[Presentation] RAISING法によるHTLV-1クロナリティ解析の評価2023
- Author(s)
  松本成良, 佐々木大介, 長谷川寛雄, 小佐井康介, 加勢田富士子, 太田賢治, 柳原克紀
- Organizer
  第70回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24233
[Presentation] HTLV-1クロナリティのRAISING法による追跡調査2023
- Author(s)
  松本成良, 佐々木大介, 山内俊輔, 斎藤益満, 加藤丈晴, 今泉芳孝, 長谷川寛雄, 宮﨑泰司, 栁原克紀
- Organizer
  第9回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24233
[Presentation] Klebsiella Pneumoniaeの高病原性を規定する遺伝子の探索2023
- Author(s)
  倉田博基、坂本啓、坪内泰志、今村亮一、金子幸弘、柳原克紀
- Organizer
  第93回　日本感染症学会西日本地方会学術集会
- Data Source
  KAKENHI-PROJECT-23K07923
[Presentation] 抗HTLV-1抗体検査結果と確認検査結果の比較検討2023
- Author(s)
  吉田麻衣子, 加勢田富士子, 長谷川寛雄, 太田賢治, 小佐井康介, 木村由美子, 柳原克紀, 三浦清徳
- Organizer
  第70回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24233
[Presentation] Hsp90阻害剤TAS-116 (pimitespib)のATL前臨床試験評価における有効性2022
- Author(s)
  伊波英克, 池辺詠美, 下崎俊介, 長谷川寛雄, 塚本善之, Yu Wang, 佐々木大介, 今泉芳孝, 宮﨑泰司, 柳原克紀, 森下和弘
- Organizer
  第8回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24233
[Presentation] RAISING法によるHTLV-1クロナリティ解析の評価2022
- Author(s)
  松本成良, 長谷川寛雄, 斎藤益満,佐々木大介, 山内俊輔, 今泉芳孝, 宮﨑泰司, 栁原克紀
- Organizer
  第8回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24233
[Presentation] 薬剤耐性菌感染症のリスク低下に向けた新しい制御法の確立2022
- Author(s)
  村田美香、森永芳智、柳原克紀
- Organizer
  第69回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08843
[Presentation] 気管支肺胞洗浄が診断に寄与した成人T細胞白血病・リンパ腫の1例2021
- Author(s)
  池谷千章, 城戸貴志, 原敦子, 小笹睦, 加藤丈晴, 渕上麻衣, 奥野大輔, 宮村拓人, 森山咲子, 石本裕士, 坂本憲穂, 今泉芳孝, 尾長谷靖, 鶴田一人, 石松祐二, 柳原克紀, 福岡順也, 迎寛
- Organizer
  第41回日本呼吸器内視鏡学会総会
- Data Source
  KAKENHI-PROJECT-21K08156
[Presentation] 新規 HTLV-1 クロナリティ解析法（RAISING 法）による ATL の病態解析2021
- Author(s)
  松本成良、斎藤益満、佐々木大介、山内俊輔、今泉芳孝、長谷川寛雄、宮﨑泰司、栁原克紀
- Organizer
  第7回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] 気管支肺胞洗浄の詳細な解析が診断に寄与した濾胞性リンパ腫再発例2021
- Author(s)
  末原　照大、城戸　貴志、坂本　憲穂、小笹　睦、時任高諄、奥野　大輔、原　敦子、佐藤　信也、石本裕士、今泉　芳孝、福岡　順也、栁原　克紀、迎　寛
- Organizer
  第333回日本内科学会九州地方会
- Data Source
  KAKENHI-PROJECT-21K08156
[Presentation] 成人T細胞白血病/リンパ腫のクローン構成を評価する新規方法の開発2021
- Author(s)
  山川智弘, 佐々木大介, 太田賢治, 加勢田富士子, 長谷川寛雄, 柳原克紀
- Organizer
  第68回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] 寛解 17 年後に再発した成人 T 細胞白血病・リンパ腫2021
- Author(s)
  西村紗央里、加藤丈晴、村山直也、佐藤信也、安東恒史、松本成良、佐々木大介、澤山靖、三好寛明、今泉芳孝、長谷川寛雄、柳原克紀、大島孝一、宮﨑泰司
- Organizer
  第7回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] AML with t(8;21)(q22;q22.1)における細胞抗原発現の解析2020
- Author(s)
  林田章也、長谷川寛雄、鶴田一人、森沙耶香、渕上麻衣、山内俊輔、岡本南、高田侑実、松本慧介、柳原克紀
- Organizer
  日本検査血液学会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] 次世代HTLV-1クロナリティ解析法(RAIS1)の開発2020
- Author(s)
  山内俊輔、斎藤益満,、長谷川寛雄、佐々木大介、渕上麻衣、森沙耶香、鶴田一人、今泉芳孝、宮崎泰司、柳原克紀
- Organizer
  日本検査血液学会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] HTLV-1キャリアに対する血漿miRNAを用いたATL発症スクリーニング検査の確立2020
- Author(s)
  新野大介、佐々木大介、山内俊介、長谷川寛雄、柳原克紀、岩永正子
- Organizer
  日本病理学会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] 上気道感染症の検査と治療方針：基本はアモキシシリン、応用は？2019
- Author(s)
  栁原克紀
- Organizer
  日本臨床微生物学会
- Data Source
  KAKENHI-PROJECT-15K09572
[Presentation] 次世代HTLV-1 クロナリティ解析法(RAIS1)の開発とその進捗2019
- Author(s)
  山内俊輔、長谷川寛雄、斎藤益満、佐々木大介、今泉芳孝、柳原克紀
- Organizer
  第6回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] HTLV-1 ウイルス組み込み配列の決定およびクローン特異的定量PCR 法の開発2019
- Author(s)
  山川智弘、宇野直輝、賀来敬仁、坂本啓、森永芳智、長谷川寛雄、栁原克紀
- Organizer
  第6回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] 敗血症における遺伝子関連検査の実運用～Verigeneシステムによる薬剤耐性菌の迅速検出～2018
- Author(s)
  栁原克紀
- Organizer
  日本感染症学会
- Data Source
  KAKENHI-PROJECT-15K09572
[Presentation] 次世代HTLV-1クロナリティ解析法の開発2018
- Author(s)
  山内俊輔、斎藤益満、長谷川寛雄、佐々木大介、賀来敬仁、宇野直輝、森永芳智、今泉芳孝、宮﨑泰司、栁原克紀
- Organizer
  第65回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] 全国におけるグラム陰性桿菌を原因とする血流感染症のアンケート調査2018
- Author(s)
  栁原克紀
- Organizer
  日本化学療法学会
- Data Source
  KAKENHI-PROJECT-15K09572
[Presentation] DDSがつくる、医療の未来2018
- Author(s)
  栁原克紀
- Organizer
  日本DDS学会
- Data Source
  KAKENHI-PROJECT-15K09572
[Presentation] 2.妊婦スクリーニング検体のHTLV-1定量検査におけるデジタルPCR法とリアルタイムPCR法の比較2017
- Author(s)
  淵直樹，三浦清徳，佐々木大介，鶴田一人，長谷川寛雄，栁原克紀，増崎英明
- Organizer
  第4回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-15K08647
[Presentation] 微生物検査の進歩―感染症診断・制御における役割を考える―2017
- Author(s)
  柳原克紀
- Organizer
  第28回日本臨床微生物学会
- Place of Presentation
  ブリックホール（長崎県・長崎市）
- Year and Date
  2017-01-20
- Invited
- Data Source
  KAKENHI-PROJECT-15K09572
[Presentation] 1.臨床検体のHTLV-1定量検査におけるデジタルPCR法とリアルタイムPCR法の比較2017
- Author(s)
  佐々木大介，長谷川寛雄，淵直樹，三浦清徳，上野友郁，吉田彩香，松本成良，山川嘉美，賀来敬仁，小佐井康介，宇野直輝，増崎英明，栁原克紀
- Organizer
  第4回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-15K08647
[Presentation] Rapid Diagnostic Testing Systems for Sepsis in Japan2017
- Author(s)
  Katsunori Yanagihara
- Organizer
  Singapore International Infectious Disease Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09572
[Presentation] Newer diagnosis for drug resistant pathogens: now and beyond2017
- Author(s)
  Katsunori Yanagihara
- Organizer
  30th International Congress of Chemotherapy and Infection
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09572
[Presentation] 感染症治療と腸内細菌叢2017
- Author(s)
  賀来敬仁、柳原克紀
- Organizer
  第28回日本臨床微生物学会
- Place of Presentation
  ブリックホール（長崎県・長崎市）
- Year and Date
  2017-01-20
- Invited
- Data Source
  KAKENHI-PROJECT-15K09572
[Presentation] 感染症診断における新展開2015
- Author(s)
  柳原克紀
- Organizer
  日本感染症学会
- Place of Presentation
  国立京都国際会館（京都府・京都市）
- Year and Date
  2015-04-17
- Data Source
  KAKENHI-PROJECT-15K09572
[Presentation] 結核患者における肝障害発現とROS関連遺伝子多型との相関解析2007
- Author(s)
  柳原克紀, 田原尚子, 稲嶺達夫, 樋口則英, 小林奨, 関雅文, 泉川公一, 大野秀明, 宮崎義継, 平潟洋一, 塚元和弘, 河野茂
- Organizer
  第47回日本呼吸器病学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18390168
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YANAGIHARA Katsunori 柳原 克紀

YANAGIHARA K. 柳原 克紀

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細菌シングルセル解析を用いた肺炎桿菌感染症の病態解明と革新的制御法の構築Principal Investigator

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The analysis of microbiota for intestinal colonization of ESBL-producing bacteriaPrincipal Investigator

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Elucidation of pathological condition of Elderly people pneumonia via analysis of microbiotaPrincipal Investigator

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Molecular characteristic of Community-Acquired methicillin-resistant Staphylococcus aureus isolates by using New Genetic DiagnosisPrincipal Investigator

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YANAGIHARA Katsunori 柳原克紀

YANAGIHARA K. 柳原克紀