KOSUGI Takahiro 小杉貴洋

Researcher Number	00771388
Other IDs
Affiliation (Current)	2025: 分子科学研究所, 協奏分子システム研究センター, 助教
Affiliation (based on the past Project Information) *help	2018 – 2024: 分子科学研究所, 協奏分子システム研究センター, 助教
Review Section/Research Field	Principal Investigator Basic Section 37010:Bio-related chemistry Except Principal Investigator Basic Section 43020:Structural biochemistry-related / Complex systems
Keywords	Principal Investigator 酵素活性 / タンパク質構造変化 / タンパク質複合体協奏的機能 / タンパク質設計 / アロステリー Except Principal Investigator X線結晶構造解析 / タンパク質工学 / 蛍光タンパク質 / ATP加水分解酵素 / タンパク質デザイン / DNAナノテクノロジー / 生物分子モーター

調節分子の違いが生み出すアロステリーの向上と拡張Principal Investigator
- Principal Investigator
  
  小杉貴洋
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Institute for Molecular Science
還元的手法と構成的手法を組合せた蛍光蛋白質の設計原理の解析と新規蛍光蛋白質開発
- Principal Investigator
  
  今村博臣
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Kyoto University
Creation of Biomolecular Engines: Engineering Naturally Occurring Biomolecules and Designing from Scratch
- Principal Investigator
  
  Furuta Ken'ya
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  National Institute of Information and Communications Technology

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Book

[Book] 実験医学増刊タンパク質の新常識 4.de novoデザインタンパク質-生物がもたないタンパク質を設計できる時代2022
- Author(s)
  古賀理恵、小杉貴洋、古賀信康
- Total Pages
  2046
- Publisher
  羊土社
- Data Source
  KAKENHI-PLANNED-18H05420
[Book] 現代化学タンパク質設計技術で目指す未来特集現代化学の最前線20232022
- Author(s)
  小杉貴洋
- Total Pages
  34
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PLANNED-18H05420
[Book] 実験医学2019年11月号2019
- Author(s)
  小杉貴洋、古賀理恵、古賀信康
- Total Pages
  147
- Publisher
  羊土社
- ISBN
  9784758125253
- Data Source
  KAKENHI-PLANNED-18H05420
[Book] 実験医学2019年11月号　p.3089‐3095「合理デザインによる新規タンパク質の創出：現状とその可能性」2019
- Author(s)
  小杉貴洋、古賀理恵、古賀信康
- Total Pages
  147
- Publisher
  羊土社
- ISBN
  9784758125253
- Data Source
  KAKENHI-PLANNED-18H05420
[Journal Article] Design of complicated all-α protein structures2024
- Author(s)
  Sakuma Koya、Kobayashi Naohiro、Sugiki Toshihiko、Nagashima Toshio、Fujiwara Toshimichi、Suzuki Kano、Kobayashi Naoya、Murata Takeshi、Kosugi Takahiro、Tatsumi-Koga Rie、Koga Nobuyasu
- Journal Title
  
  Nature Structural and Molecular Biology
  
  Volume: 31 Issue: 2 Pages: 275-282
- DOI
  10.1038/s41594-023-01147-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05420
[Journal Article] Design of allosteric sites into rotary motor V1-ATPase by restoring lost function of pseudo-active sites2023
- Author(s)
  Kosugi Takahiro、Iida Tatsuya、Tanabe Mikio、Iino Ryota、Koga Nobuyasu
- Journal Title
  
  Nature Chemistry
  
  Volume: 15 Issue: 11 Pages: 1591-1598
- DOI
  10.1038/s41557-023-01256-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05420
[Journal Article] Tackle “Molecular Engine” by early-career researchers2022
- Author(s)
  Otomo Akihiro、Kosugi Takahiro
- Journal Title
  
  Biophysics and Physicobiology
  
  Volume: 19 Issue: 0 Pages: n/a
- DOI
  10.2142/biophysico.bppb-v19.0039
- ISSN
  2189-4779
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05420
[Journal Article] Uncovering the design principles of supramolecular assemblies through manipulation of the structures, dynamics, and functions2022
- Author(s)
  Miyazaki Makito、Kosugi Takahiro
- Journal Title
  
  Biophysics and Physicobiology
  
  Volume: 19 Issue: 0 Pages: n/a
- DOI
  10.2142/biophysico.bppb-v19.0031
- ISSN
  2189-4779
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KK0420, KAKENHI-PROJECT-21K19220, KAKENHI-PUBLICLY-21H00399, KAKENHI-PLANNED-18H05420
[Journal Article] Design of complicated all-α protein structures2021
- Author(s)
  Sakuma Koya、Kobayashi Naohiro、Sugiki Toshihiko、Nagashima Toshio、Fujiwara Toshimichi、Suzuki Kano、Kobayashi Naoya、Murata Takeshi、Kosugi Takahiro、Koga Rie、Koga Nobuyasu
- Journal Title
  
  bioRxiv
  
  Volume: 2021.07.14.449347
- DOI
  10.1101/2021.07.14.449347
- Data Source
  KAKENHI-PLANNED-18H05420
[Journal Article] State-Targeting Stabilization of Adenosine A2A Receptor by Fusing a Custom-Made De Novo Designed α-Helical Protein2021
- Author(s)
  Mitsumoto Masaya、Sugaya Kanna、Kazama Kazuki、Nakano Ryosuke、Kosugi Takahiro、Murata Takeshi、Koga Nobuyasu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 23 Pages: 12906-12906
- DOI
  10.3390/ijms222312906
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05425, KAKENHI-PLANNED-18H05420
[Journal Article] Robust folding of a de novo designed ideal protein even with most of the core mutated to valine.2020
- Author(s)
  R. Koga, M. Yamamoto, K. Takahiro, N. Kobayashi, T. Sugiki, T. Fujiwara and N. Koga
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 117 Issue: 49 Pages: 31149-31156
- DOI
  10.1073/pnas.2002120117
- NAID
  120006952207
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06152, KAKENHI-PLANNED-18H05420
[Journal Article] De Novo Design of Allosteric Control into Rotary Motor V1-ATPase by Restoring Lost Function2020
- Author(s)
  Kosugi Takahiro、Iida Tatsuya、Tanabe Mikio、Iino Ryota、Koga Nobuyasu
- Journal Title
  
  bioRxiv
  
  Volume: 2020.09.09
- DOI
  10.1101/2020.09.09.288571
- Open Access
- Data Source
  KAKENHI-PLANNED-18H05420
[Journal Article] ShadowR: a novel chromoprotein with reduced non-specific binding and improved expression in living cells2019
- Author(s)
  Murakoshi Hideji、Horiuchi Hiroshi、Kosugi Takahiro、Onda Maki、Sato Aiko、Koga Nobuyasu、Nabekura Junichi
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 12072-12072
- DOI
  10.1038/s41598-019-48604-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14825, KAKENHI-PUBLICLY-18H04748, KAKENHI-PUBLICLY-19H05434, KAKENHI-PROJECT-18H02708, KAKENHI-PROJECT-18K19382, KAKENHI-PROJECT-16H06280, KAKENHI-PLANNED-18H05420
[Presentation] タンパク質設計技術による定量生物学を目指して2024
- Author(s)
  小杉貴洋
- Organizer
  定量生物学の会第十一回年会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] Allosteric control of rotary molecular motor by using protein design method2024
- Author(s)
  小杉貴洋
- Organizer
  OIST-JST JOINT MEETING
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] タンパク質設計技術は単細胞生物研究に役立つのか？2024
- Author(s)
  小杉貴洋
- Organizer
  2023年度国立遺伝学研究所研究会「微生物の細胞複製システムから紐解く生命のデザイン」
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] 構造解析が導くタンパク質の設計・改造とその理解2024
- Author(s)
  小杉貴洋
- Organizer
  2023年度量子ビームサイエンスフェスタ
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] Toward understanding roles of yeast Tor complexes by structure-based engineering approach2023
- Author(s)
  小杉貴洋
- Organizer
  第61回日本生物物理学会シンポジウム「トア複合体による細胞応答の仕組みを理解する」
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] Control of functions exerted by protein complexes using protein design methods2023
- Author(s)
  小杉貴洋
- Organizer
  16th Eurasia Conference on Chemical Sciences 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] 蛋白質複合体が生み出す協奏的な機能の合理的な制御を目指して2023
- Author(s)
  小杉貴洋
- Organizer
  第23回蛋白質科学会年会シンポジウム「加速するタンパク質デザイン」
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] 計算機設計技術を用いたスーパー酵素の創出2023
- Author(s)
  小杉貴洋
- Organizer
  第96回日本生化学会大会シンポジウム「情報計算科学にもとづく酵素の創成と応用～スーパー酵素が切り拓く生化学の新時代～」
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] Toward developing a new field of biology based on protein design, The 2157th NIG Biological Symposium2023
- Author(s)
  小杉貴洋
- Organizer
  The 2157th NIG Biological Symposium
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] Allosteric control of rotary motor V1-ATPase by redesigning pseudo-active sites2023
- Author(s)
  小杉貴洋
- Organizer
  The East Asia Single-Molecule Biology Symposium 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] タンパク質設計技術による細胞内回転型分子モーターの制御を目指して2023
- Author(s)
  小杉貴洋
- Organizer
  第12回分子モーター討論会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] 高次構造体の協奏的機能を合理的に制御することを目指して2022
- Author(s)
  小杉貴洋
- Organizer
  第60回日本生物物理学会年会　 JST さきがけ「細胞の動的高次構造体」共催シンポジウム　高次構造体を自在に操る
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] 蛋白質（計算）科学から始まる生物学を目指して2022
- Author(s)
  小杉貴洋
- Organizer
  第22回日本蛋白質科学会年会シンポジウム「未来の話をしよう！」
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] 人生の選択：その時私が考えたこと2022
- Author(s)
  小杉貴洋
- Organizer
  蛋白質科学会若手の会第二回研究交流会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] 機能を持った“新しい”蛋白質の設計2022
- Author(s)
  小杉貴洋
- Organizer
  第22回日本蛋白質科学会年会ワークショップ「AlphaFoldの時代の分子シミュレーション」
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] 蛋白質（計算）科学から始まる生物学を目指して2022
- Author(s)
  小杉貴洋
- Organizer
  第22回日本蛋白質科学会年会シンポジウム「未来の話をしよう！」
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] アロステリック部位を設計して回転分子モーターを制御する2022
- Author(s)
  小杉貴洋
- Organizer
  第6回学術変革(B) SPEED journal club
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] Allosteric control of rotary molecular motor by redesigning non-catalytic interface2022
- Author(s)
  Takahiro Kosugi
- Organizer
  Sendai2022 Workshop
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] 機能を持った“新しい”蛋白質の設計2022
- Author(s)
  小杉貴洋
- Organizer
  第22回日本蛋白質科学会年会ワークショップ「AlphaFoldの時代の分子シミュレーション」
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] タンパク質設計技術を用いて生体内化学反応を理解・制御する2022
- Author(s)
  小杉貴洋
- Organizer
  化学反応のポテンシャル曲面とダイナミックス
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] 高次構造体の協奏的機能を合理的に制御することを目指して2022
- Author(s)
  小杉貴洋
- Organizer
  第60回日本生物物理学会年会　 JST さきがけ「細胞の動的高次構造体」共催シンポジウム　高次構造体を自在に操る（
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] タンパク質設計技術を用いて生体内化学反応を理解・制御する2022
- Author(s)
  小杉貴洋
- Organizer
  化学反応のポテンシャル曲面とダイナミックス
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] アロステリック部位を設計して回転分子モーターを制御する2022
- Author(s)
  小杉貴洋
- Organizer
  第6回学術変革(B) SPEED journal club
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] 人生の選択：その時私が考えたこと2022
- Author(s)
  小杉貴洋
- Organizer
  蛋白質科学会若手の会第二回研究交流会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] 失われた機能を復活させて回転分子モーターをアロステリック制御する2021
- Author(s)
  小杉貴洋
- Organizer
  第10回分子モーター討論会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] Rosettaから見たAlphaFold22021
- Author(s)
  小杉貴洋
- Organizer
  第59回日本生物物理学会　第8回会員総会シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] DESIGN OF GLOBIN-LIKE COMPLICATED FOLDS2020
- Author(s)
  K. Sakuma, N. Kobayashi, T. Sugiki, K. Suzuki, N. Kobayashi, T. Kosugi, T. Murata, R. Koga, N. Koga
- Organizer
  The Biophysical Society Annual Meeting 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] Allosteric Regulation of V1-ATPase by Designing Walker Motif in Non-catalytic Interface2019
- Author(s)
  T. Kosugi
- Organizer
  2nd Tokyo ATPase Workshop
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] Design of Allosteric Site to Regulate Rotary Molecular Motor V1-ATPase2019
- Author(s)
  T. Kosugi
- Organizer
  Frontier Bioorganization Forum 2019
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] Allosteric Regulation of V1-ATPase by Designing Walker Motif in Non-catalytic Interface2019
- Author(s)
  T. Kosugi
- Organizer
  2nd Tokyo ATPase Worksho
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] De novo design of ATP-binding protein with two-domain structure2019
- Author(s)
  H. Yamada, K. Nakamura, T. Kosugi, N. Koga
- Organizer
  2nd Tokyo ATPase Workshop
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] Rational Design of ATP Binding Site to Understand Rotary Molecular Motor2018
- Author(s)
  T. Kosugi
- Organizer
  The 79th Okazaki Conference: Synthetic, Biological, and Hybrid Molecular Engines
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420

1. Furuta Ken'ya (40571831)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 古賀信康 (50432571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
3. 今村博臣 (20422545)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 今田勝巳 (40346143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 伊藤創平 (70372836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MURATA Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 小林直宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 堀内浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOSUGI Takahiro 小杉 貴洋

Research Projects

Research Products

Co-Researchers

調節分子の違いが生み出すアロステリーの向上と拡張Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

還元的手法と構成的手法を組合せた蛍光蛋白質の設計原理の解析と新規蛍光蛋白質開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Creation of Biomolecular Engines: Engineering Naturally Occurring Biomolecules and Designing from Scratch

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 実験医学増刊 タンパク質の新常識 4.de novoデザインタンパク質-生物がもたないタンパク質を設計できる時代2022

Author(s)

Total Pages

Publisher

Data Source

[Book] 現代化学 タンパク質設計技術で目指す未来 特集 現代化学の最前線20232022

Author(s)

Total Pages

Publisher

Data Source

[Book] 実験医学2019年11月号2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 実験医学2019年11月号 p.3089‐3095「合理デザインによる新規タンパク質の創出：現状とその可能性」2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Design of complicated all-α protein structures2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Design of allosteric sites into rotary motor V1-ATPase by restoring lost function of pseudo-active sites2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tackle “Molecular Engine” by early-career researchers2022

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Uncovering the design principles of supramolecular assemblies through manipulation of the structures, dynamics, and functions2022

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Design of complicated all-α protein structures2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] State-Targeting Stabilization of Adenosine A2A Receptor by Fusing a Custom-Made De Novo Designed α-Helical Protein2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Robust folding of a de novo designed ideal protein even with most of the core mutated to valine.2020

Author(s)

KOSUGI Takahiro 小杉貴洋

[Book] 実験医学増刊タンパク質の新常識 4.de novoデザインタンパク質-生物がもたないタンパク質を設計できる時代2022

[Book] 現代化学タンパク質設計技術で目指す未来特集現代化学の最前線20232022

[Book] 実験医学2019年11月号　p.3089‐3095「合理デザインによる新規タンパク質の創出：現状とその可能性」2019