CHANG Tsung-che 張宗哲

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Chang Tsung-Che 張宗哲

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Researcher Number	00774853
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 開拓研究所, 研究員
Affiliation (based on the past Project Information) *help	2024 – 2025: 国立研究開発法人理化学研究所, 開拓研究本部, 研究員 2024: 東京科学大学, 物質理工学院, 特任助教 2023: 東京工業大学, 物質理工学院, 特任助教 2019 – 2023: 国立研究開発法人理化学研究所, 開拓研究本部, 特別研究員
Review Section/Research Field	Principal Investigator Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Basic Section 37030:Chemical biology-related Except Principal Investigator Medium-sized Section 37:Biomolecular chemistry and related fields / Basic Section 55010:General surgery and pediatric surgery-related
Keywords	Principal Investigator In vivo synthesis / Prodrug / Artificial metalloenzyme / artificial metalloenzyme / polymer / polymerization / Glycoalbumin / Sialic acid / Metal catalysis / Immunotherapy … More / Gold metal / Sialyltransferase / Acrolein / Sialyltransferases / Glycoalbumin DDS / Chemical glycosylation / Prodrug activation / Gold-catalysis / chemical glycosylation / metal-carrier / drug-release / Glycan / Gold-mediated reaction / drug synthesis / gold catalysis / biocompatibility / biocatalysis … More Except Principal Investigator エクソソーム / 人工金属酵素 / 糖鎖 / がん / 生体内合成 / スフィンゴシン－1－リン酸 / ドラッグデリバリーシステム / 治療 / オルガノイド / 創薬 / マウスモデル / 薬剤耐性 / 脂質メディエーター / ドラッグデリバリー / 乳癌 / スフィンゴシン-1-リン酸 Less

Development of Novel Therapies Using Drug Delivery Systems Targeting Lipid Mediators in Breast Cancer
- Principal Investigator
  
  Nagahashi Masayuki
- Project Period (FY)
  2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Hyogo Medical University
Catalytic cancer therapy by biocompatible artificial metalloenzyme
- Principal Investigator
  
  田中克典
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Institute of Science Tokyo
In vivo polymer synthesis for therapeutic application via glycosylated artificial metalloenzymesPrincipal Investigator
- Principal Investigator
  
  張宗哲
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Institute of Physical and Chemical Research
pplication of gold-catalyzed hydroamination in sialic acids for the cancer-localized in vivo release of an immunotherapy drugPrincipal Investigator
- Principal Investigator
  
  CHANG Tsung-che
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Tokyo Institute of Technology
  Institute of Physical and Chemical Research
Application of gold-catalyzed glycosylation under aqueous condition for the tumor-localized in vivo synthesis of anticancer drugsPrincipal Investigator
- Principal Investigator
  
  Chang Tsung-Che
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Institute of Physical and Chemical Research

All 2024 2023 2021 2020 2019

All Journal Article Presentation

[Journal Article] Anticancer approach by targeted activation of a global inhibitor of sialyltransferases with acrolein2024
- Author(s)
  Kasahara Takatsugu、Chang Tsung-Che、Yoshioka Hiromasa、Urano Sayaka、Egawa Yasuko、Inoue Michiko、Tahara Tsuyoshi、Koji Morimoto、Pradipta Ambara R.、Tanaka Katsunori
- Journal Title
  
  Chemical Science
  
  Volume: - Issue: 25 Pages: 9566-9573
- DOI
  10.1039/d4sc00969j
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05269, KAKENHI-PROJECT-24H00491, KAKENHI-PROJECT-24K08629, KAKENHI-PROJECT-23K17971, KAKENHI-PROJECT-23K14331
[Journal Article] 生体内合成化学治療：マウス体内での金属触媒反応によるがん治療2024
- Author(s)
  田中克典, T.-C. Chang
- Journal Title
  
  有機合成化学協会誌
  
  Volume: 82 Pages: 535-543
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24H00491
[Journal Article] Literature Coverage: Catalytic olefin methathesis in blood2024
- Author(s)
  Chang Tsung‐Che、Tanaka Katsunori
- Journal Title
  
  Synform
  
  Volume: 20 Issue: 04 Pages: A053-A068
- DOI
  10.1055/s-0040-1720627
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24H00491
[Journal Article] In Vivo Synthetic Anticancer Approach by Resourcing Mouse Blood Albumin as a Biocompatible Artificial Metalloenzyme2024
- Author(s)
  Imai Kyosuke、Muguruma Kyohei、Nakamura Akiko、Kusakari Yuriko、Chang Tsung‐Che、Pradipta Ambara R.、Tanaka Katsunori
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 10.1002/anie.202411225
- DOI
  10.1002/anie.202411225
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24H00491, KAKENHI-PROJECT-24KJ1086
[Journal Article] Synthesis of phenanthridine derivatives by a water-compatible gold-catalyzed hydroamination2024
- Author(s)
  Lin Yixuan、Hashimoto Riichi、Chang Tsung-Che、Tanaka Katsunori
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 113 Pages: 117928-117928
- DOI
  10.1016/j.bmc.2024.117928
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24H00491, KAKENHI-PROJECT-23K19258
[Journal Article] Chemistry-driven translocation of glycosylated proteins in mice2024
- Author(s)
  Yamada Kenshiro、Mukaimine Akari、Nakamura Akiko、Kusakari Yuriko、Pradipta Ambara R.、Chang Tsung-Che、Tanaka Katsunori
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1 Pages: 7409-7409
- DOI
  10.1038/s41467-024-51342-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24H00491, KAKENHI-PROJECT-24K08629
[Journal Article] Catalytic olefin metathesis in blood2023
- Author(s)
  Nasibullin Igor、Yoshioka Hiromasa、Mukaimine Akari、Nakamura Akiko、Kusakari Yuriko、Chang Tsung-Che、Tanaka Katsunori
- Journal Title
  
  Chemical Science
  
  Volume: 14 Issue: 40 Pages: 11033-11039
- DOI
  10.1039/d3sc03785a
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14331, KAKENHI-PROJECT-21K05302
[Journal Article] Prodrug Activation by Gold Artificial Metalloenzyme‐Catalyzed Synthesis of Phenanthridinium Derivatives via Hydroamination2021
- Author(s)
  Chang Tsung‐Che、Vong Kenward、Yamamoto Tomoya、Tanaka Katsunori
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 60 Issue: 22 Pages: 2-11
- DOI
  10.1002/anie.202100369
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K15708, KAKENHI-PROJECT-21H02065, KAKENHI-PROJECT-21K19042
[Journal Article] In vivo metal-catalyzed SeCT therapy by a proapoptotic peptide.2021
- Author(s)
  hmad, P.; Muguruma, K.; Chang, T.-C.; Tamura, S.; Tsubokura, K.; Egawa, Y.; Suzuki, T.; Dohmae, N.; Nakao, Y.; *Tanaka, K.
- Journal Title
  
  Chem. Sci.
  
  Volume: 12 Issue: 37 Pages: 12266-12273
- DOI
  10.1039/d1sc01784e
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05718, KAKENHI-PROJECT-19K15708, KAKENHI-PROJECT-21H02065, KAKENHI-PROJECT-19J00396, KAKENHI-PROJECT-21K19042, KAKENHI-PROJECT-20K15968
[Journal Article] In vivo organic synthesis by metal catalysts2021
- Author(s)
  Chang Tsung-Che、Tanaka Katsunori
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 46 Pages: 116353-116353
- DOI
  10.1016/j.bmc.2021.116353
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K15708, KAKENHI-PROJECT-21H02065, KAKENHI-PROJECT-21K19042
[Journal Article] Epoc group: transformable protecting group with gold(III)-catalyzed fluorene formation2021
- Author(s)
  Yamamoto Tomoya、Chang Tsung-Che、Tanaka Katsunori
- Journal Title
  
  Chemical Science
  
  Volume: 12 Issue: 32 Pages: 10703-10709
- DOI
  10.1039/d1sc03125b
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K15708, KAKENHI-PROJECT-21H02065, KAKENHI-PROJECT-21K19042
[Journal Article] Enantioselective synthesis of cyclic and linear diamines by imine cycloadditions2020
- Author(s)
  Chang Tsung‐Che、Pradipta Ambara R.、Tanaka Katsunori
- Journal Title
  
  Chirality
  
  Volume: 32 Issue: 9 Pages: 1160-1168
- DOI
  10.1002/chir.23265
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K15708, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-18K14341
[Journal Article] Bioorthogonal release of anticancer drugs via gold-triggered 2-alkynylbenzamide cyclization2020
- Author(s)
  Vong Kenward、Yamamoto Tomoya、Chang Tsung-che、Tanaka Katsunori
- Journal Title
  
  Chemical Science
  
  Volume: 11 Issue: 40 Pages: 10928-10933
- DOI
  10.1039/d0sc04329j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K15708
[Journal Article] Development of α-Gal-Antibody Conjugates to Increase Immune Response by Recruiting Natural Antibodies2019
- Author(s)
  Sianturi Julinton、Manabe Yoshiyuki、Li Hao-Sheng、Chiu Li-Ting、Chang Tsung-Che、Tokunaga Kento、Kabayama Kazuya、Tanemura Masahiro、Takamatsu Shinji、Miyoshi Eiji、Hung Shang-Cheng、Fukase Koichi
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 58 Issue: 14 Pages: 4526-4530
- DOI
  10.1002/anie.201812914
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05356, KAKENHI-PLANNED-15H05836, KAKENHI-PROJECT-16H01885, KAKENHI-PROJECT-17H03571, KAKENHI-PROJECT-16H05924, KAKENHI-PROJECT-17K19201, KAKENHI-PROJECT-19K09120, KAKENHI-PROJECT-19K15708, KAKENHI-PROJECT-19H03562
[Journal Article] Fluorescence “Turn-on” Lectin Sensors Fabricated by Ligand-Assisted Labeling Probes for Detecting Protein?Glycoprotein Interactions2019
- Author(s)
  Li Pei-Jhen、Anwar Mohammad Tarigue、Fan Chen-Yo、Juang Duane S.、Lin Hsin-Yi、Chang Tsung-Che、Kawade Sachin Kisan、Chen Hsiang-Jung、Chen Yu-Ju、Tan Kui-Thong、Lin Chun-Cheng
- Journal Title
  
  Biomacromolecules
  
  Volume: 21 Issue: 2 Pages: 815-824
- DOI
  10.1021/acs.biomac.9b01495
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K15708
[Presentation] Catalytic olefin metathesis in blood2023
- Author(s)
  Tsung-Che Chang、Igor Nasibullin、吉岡広大、向峯あかり、田中克典
- Organizer
  日本化学会第103春季年会
- Data Source
  KAKENHI-PROJECT-21K05302
[Presentation] がん代謝物をトリガーとした糖転移酵素阻害剤の活性化とがん治療2023
- Author(s)
  原隆継、Tsung-Che Chang、浦野清香、Ambara R. Pradipta、田中克典
- Organizer
  日本化学会第103春季年会
- Data Source
  KAKENHI-PROJECT-21K05302
[Presentation] A therapeutic approach for cancers with special genetic mutations using in vivo synthetic chemistry2021
- Author(s)
  Tsung-Che Chang
- Organizer
  日本化学会第102春季年会
- Data Source
  KAKENHI-PROJECT-19K15708
[Presentation] Glycotargeting as metal carrier system for in vivo synthesis2021
- Author(s)
  Tsung-Che Chang, Katsunori Tanaka
- Organizer
  RIKEN-Max Planck Joint Research Center for System Chemical Biology the Seventh Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K15708
[Presentation] Anticancer approach by a gold artificial metalloenzyme-catalyzed synthesis of quaternary ammonium derivatives via hydroamination2021
- Author(s)
  Tsung-Che Chang, Tomoya Yamamoto, Katsunori Tanaka
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-19K15708
[Presentation] In vivo synthesis of natural product-derived drugs via gold artificial metalloenzyme,2021
- Author(s)
  Tsung-Che Chang
- Organizer
  第63回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-19K15708
[Presentation] Targeted delivery of an inhibitor of glycosyltransferase to cancer cells2020
- Author(s)
  Tsung-Che Chang, Katsunori Tanaka
- Organizer
  日本化学会第100春季年会
- Data Source
  KAKENHI-PROJECT-19K15708
[Presentation] Toward in vivo gold (III) comples-catalyzed glycosylation2019
- Author(s)
  Tsung-Che.Chang, Katsunori Tanaka
- Organizer
  第2回ケミカルプローブ合同合宿セミナー
- Data Source
  KAKENHI-PROJECT-19K15708
[Presentation] Towards in vivo gold (III)-catalyzed chemical glycosylation via intramolecular aglycone delivery2019
- Author(s)
  Tsung-Che.Chang, Katsunori Tanaka
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-19K15708
[Presentation] Toward in vivo gold (III) complex-catalyzed glycosylation for targeting cancer cells2019
- Author(s)
  Tsung-Che.Chang, Katsunori Tanaka
- Organizer
  The 18th Asian Chemical Congress and the 20th General Assembly of the Federation of Asian Chemical Societies
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K15708
[Presentation] Synthesis and biological applications of glycoconjugates for cancer therapy2019
- Author(s)
  Tsung-Che.Chang, Katsunori Tanaka
- Organizer
  RIKEN-Max Planck Joint Research Center for System Chemical Biology the Seventh Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K15708

1. Nagahashi Masayuki (30743918)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 奥田修二郎 (00512310)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 盛本浩二 (00599996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 阿部学 (10334674)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 三好康雄 (50283784)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 大村谷昌樹 (60398229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. PRADIPTA AMBARA (90631648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 田中克典 (00403098)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
9. KABAYAMA Kazuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 田村理

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 吉岡広大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

CHANG Tsung-che 張 宗哲

Chang Tsung-Che 張 宗哲

Research Projects

Research Products

Co-Researchers

Development of Novel Therapies Using Drug Delivery Systems Targeting Lipid Mediators in Breast Cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Catalytic cancer therapy by biocompatible artificial metalloenzyme

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

In vivo polymer synthesis for therapeutic application via glycosylated artificial metalloenzymesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

pplication of gold-catalyzed hydroamination in sialic acids for the cancer-localized in vivo release of an immunotherapy drugPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Application of gold-catalyzed glycosylation under aqueous condition for the tumor-localized in vivo synthesis of anticancer drugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Anticancer approach by targeted activation of a global inhibitor of sialyltransferases with acrolein2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 生体内合成化学治療：マウス体内での金属触媒反応によるがん治療2024

Author(s)

Journal Title

Data Source

[Journal Article] Literature Coverage: Catalytic olefin methathesis in blood2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In Vivo Synthetic Anticancer Approach by Resourcing Mouse Blood Albumin as a Biocompatible Artificial Metalloenzyme2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of phenanthridine derivatives by a water-compatible gold-catalyzed hydroamination2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chemistry-driven translocation of glycosylated proteins in mice2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Catalytic olefin metathesis in blood2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prodrug Activation by Gold Artificial Metalloenzyme‐Catalyzed Synthesis of Phenanthridinium Derivatives via Hydroamination2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vivo metal-catalyzed SeCT therapy by a proapoptotic peptide.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vivo organic synthesis by metal catalysts2021

CHANG Tsung-che 張宗哲

Chang Tsung-Che 張宗哲