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CHANG Tsung-che  張 宗哲

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Chang Tsung-Che  張 宗哲

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Researcher Number 00774853
Affiliation (Current) 2025: 国立研究開発法人理化学研究所, 開拓研究所, 研究員
Affiliation (based on the past Project Information) *help 2024: 国立研究開発法人理化学研究所, 開拓研究本部, 研究員
2023 – 2024: 東京工業大学, 物質理工学院, 特任助教
2019 – 2024: 国立研究開発法人理化学研究所, 開拓研究本部, 特別研究員
Review Section/Research Field
Principal Investigator
Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Basic Section 37030:Chemical biology-related
Except Principal Investigator
Basic Section 55010:General surgery and pediatric surgery-related / Medium-sized Section 37:Biomolecular chemistry and related fields
Keywords
Principal Investigator
In vivo synthesis / Prodrug / Artificial metalloenzyme / polymer / Glycoalbumin / Sialic acid / Metal catalysis / Immunotherapy / Gold metal / Sialyltransferase … More / Acrolein / Sialyltransferases / Glycoalbumin DDS / Chemical glycosylation / Prodrug activation / Gold-catalysis / chemical glycosylation / metal-carrier / drug-release / Glycan / Gold-mediated reaction / drug synthesis / gold catalysis / artificial metalloenzyme / biocompatibility / biocatalysis … More
Except Principal Investigator
創薬 / マウスモデル / 薬剤耐性 / ドラッグデリバリー / スフィンゴシン-1-リン酸 / 脂質メディエーター / ドラッグデリバリーシステム / 治療 / 乳癌 / スフィンゴシン-1-リン酸 / エクソソーム / 人工金属酵素 / 糖鎖 / がん / 生体内合成 Less
  • Research Projects

    (5 results)
  • Research Products

    (20 results)
  • Co-Researchers

    (11 People)
  •  In vivo polymer synthesis for therapeutic application via glycosylated artificial metalloenzymesPrincipal Investigator

    • Principal Investigator
      張 宗哲
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 37030:Chemical biology-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  Catalytic cancer therapy by biocompatible artificial metalloenzyme

    • Principal Investigator
      田中 克典
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 37:Biomolecular chemistry and related fields
    • Research Institution
      Institute of Science Tokyo
  •  乳癌における脂質メディエーターを標的とする薬物送達システムを用いた新規治療の開発

    • Principal Investigator
      永橋 昌幸
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Hyogo Medical University
  •  pplication of gold-catalyzed hydroamination in sialic acids for the cancer-localized in vivo release of an immunotherapy drugPrincipal Investigator

    • Principal Investigator
      CHANG Tsung-che
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
    • Research Institution
      Tokyo Institute of Technology
      Institute of Physical and Chemical Research
  •  Application of gold-catalyzed glycosylation under aqueous condition for the tumor-localized in vivo synthesis of anticancer drugsPrincipal Investigator

    • Principal Investigator
      Chang Tsung-Che
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
    • Research Institution
      Institute of Physical and Chemical Research

All 2023 2021 2020 2019

All Journal Article Presentation

  • [Journal Article] Catalytic olefin metathesis in blood2023

    • Author(s)
      Nasibullin Igor、Yoshioka Hiromasa、Mukaimine Akari、Nakamura Akiko、Kusakari Yuriko、Chang Tsung-Che、Tanaka Katsunori
    • Journal Title

      Chemical Science

      Volume: 14 Issue: 40 Pages: 11033-11039

    • DOI

      10.1039/d3sc03785a

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K14331, KAKENHI-PROJECT-21K05302
  • [Journal Article] Prodrug Activation by Gold Artificial Metalloenzyme‐Catalyzed Synthesis of Phenanthridinium Derivatives via Hydroamination2021

    • Author(s)
      Chang Tsung‐Che、Vong Kenward、Yamamoto Tomoya、Tanaka Katsunori
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 60 Issue: 22 Pages: 2-11

    • DOI

      10.1002/anie.202100369

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K15708, KAKENHI-PROJECT-21H02065, KAKENHI-PROJECT-21K19042
  • [Journal Article] In vivo metal-catalyzed SeCT therapy by a proapoptotic peptide.2021

    • Author(s)
      hmad, P.; Muguruma, K.; Chang, T.-C.; Tamura, S.; Tsubokura, K.; Egawa, Y.; Suzuki, T.; Dohmae, N.; Nakao, Y.; *Tanaka, K.
    • Journal Title

      Chem. Sci.

      Volume: 12 Issue: 37 Pages: 12266-12273

    • DOI

      10.1039/d1sc01784e

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K05718, KAKENHI-PROJECT-19K15708, KAKENHI-PROJECT-21H02065, KAKENHI-PROJECT-19J00396, KAKENHI-PROJECT-21K19042, KAKENHI-PROJECT-20K15968
  • [Journal Article] In vivo organic synthesis by metal catalysts2021

    • Author(s)
      Chang Tsung-Che、Tanaka Katsunori
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 46 Pages: 116353-116353

    • DOI

      10.1016/j.bmc.2021.116353

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K15708, KAKENHI-PROJECT-21H02065, KAKENHI-PROJECT-21K19042
  • [Journal Article] Epoc group: transformable protecting group with gold(III)-catalyzed fluorene formation2021

    • Author(s)
      Yamamoto Tomoya、Chang Tsung-Che、Tanaka Katsunori
    • Journal Title

      Chemical Science

      Volume: 12 Issue: 32 Pages: 10703-10709

    • DOI

      10.1039/d1sc03125b

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K15708, KAKENHI-PROJECT-21H02065, KAKENHI-PROJECT-21K19042
  • [Journal Article] Enantioselective synthesis of cyclic and linear diamines by imine cycloadditions2020

    • Author(s)
      Chang Tsung‐Che、Pradipta Ambara R.、Tanaka Katsunori
    • Journal Title

      Chirality

      Volume: 32 Issue: 9 Pages: 1160-1168

    • DOI

      10.1002/chir.23265

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K15708, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-18K14341
  • [Journal Article] Bioorthogonal release of anticancer drugs via gold-triggered 2-alkynylbenzamide cyclization2020

    • Author(s)
      Vong Kenward、Yamamoto Tomoya、Chang Tsung-che、Tanaka Katsunori
    • Journal Title

      Chemical Science

      Volume: 11 Issue: 40 Pages: 10928-10933

    • DOI

      10.1039/d0sc04329j

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K15708
  • [Journal Article] Development of α-Gal-Antibody Conjugates to Increase Immune Response by Recruiting Natural Antibodies2019

    • Author(s)
      Sianturi Julinton、Manabe Yoshiyuki、Li Hao-Sheng、Chiu Li-Ting、Chang Tsung-Che、Tokunaga Kento、Kabayama Kazuya、Tanemura Masahiro、Takamatsu Shinji、Miyoshi Eiji、Hung Shang-Cheng、Fukase Koichi
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 58 Issue: 14 Pages: 4526-4530

    • DOI

      10.1002/anie.201812914

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K05356, KAKENHI-PLANNED-15H05836, KAKENHI-PROJECT-16H01885, KAKENHI-PROJECT-17H03571, KAKENHI-PROJECT-16H05924, KAKENHI-PROJECT-17K19201, KAKENHI-PROJECT-19K09120, KAKENHI-PROJECT-19K15708, KAKENHI-PROJECT-19H03562
  • [Journal Article] Fluorescence “Turn-on” Lectin Sensors Fabricated by Ligand-Assisted Labeling Probes for Detecting Protein?Glycoprotein Interactions2019

    • Author(s)
      Li Pei-Jhen、Anwar Mohammad Tarigue、Fan Chen-Yo、Juang Duane S.、Lin Hsin-Yi、Chang Tsung-Che、Kawade Sachin Kisan、Chen Hsiang-Jung、Chen Yu-Ju、Tan Kui-Thong、Lin Chun-Cheng
    • Journal Title

      Biomacromolecules

      Volume: 21 Issue: 2 Pages: 815-824

    • DOI

      10.1021/acs.biomac.9b01495

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K15708
  • [Presentation] Catalytic olefin metathesis in blood2023

    • Author(s)
      Tsung-Che Chang、Igor Nasibullin、吉岡広大、向峯あかり、田中克典
    • Organizer
      日本化学会第103春季年会
    • Data Source
      KAKENHI-PROJECT-21K05302
  • [Presentation] がん代謝物をトリガーとした糖転移酵素阻害剤の活性化とがん治療2023

    • Author(s)
      原隆継、Tsung-Che Chang、浦野清香、Ambara R. Pradipta、田中克典
    • Organizer
      日本化学会第103春季年会
    • Data Source
      KAKENHI-PROJECT-21K05302
  • [Presentation] A therapeutic approach for cancers with special genetic mutations using in vivo synthetic chemistry2021

    • Author(s)
      Tsung-Che Chang
    • Organizer
      日本化学会第102春季年会
    • Data Source
      KAKENHI-PROJECT-19K15708
  • [Presentation] Glycotargeting as metal carrier system for in vivo synthesis2021

    • Author(s)
      Tsung-Che Chang, Katsunori Tanaka
    • Organizer
      RIKEN-Max Planck Joint Research Center for System Chemical Biology the Seventh Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K15708
  • [Presentation] Anticancer approach by a gold artificial metalloenzyme-catalyzed synthesis of quaternary ammonium derivatives via hydroamination2021

    • Author(s)
      Tsung-Che Chang, Tomoya Yamamoto, Katsunori Tanaka
    • Organizer
      日本化学会第101春季年会
    • Data Source
      KAKENHI-PROJECT-19K15708
  • [Presentation] In vivo synthesis of natural product-derived drugs via gold artificial metalloenzyme,2021

    • Author(s)
      Tsung-Che Chang
    • Organizer
      第63回天然有機化合物討論会
    • Data Source
      KAKENHI-PROJECT-19K15708
  • [Presentation] Targeted delivery of an inhibitor of glycosyltransferase to cancer cells2020

    • Author(s)
      Tsung-Che Chang, Katsunori Tanaka
    • Organizer
      日本化学会第100春季年会
    • Data Source
      KAKENHI-PROJECT-19K15708
  • [Presentation] Toward in vivo gold (III) comples-catalyzed glycosylation2019

    • Author(s)
      Tsung-Che.Chang, Katsunori Tanaka
    • Organizer
      第2回ケミカルプローブ合同合宿セミナー
    • Data Source
      KAKENHI-PROJECT-19K15708
  • [Presentation] Towards in vivo gold (III)-catalyzed chemical glycosylation via intramolecular aglycone delivery2019

    • Author(s)
      Tsung-Che.Chang, Katsunori Tanaka
    • Organizer
      日本化学会第99春季年会
    • Data Source
      KAKENHI-PROJECT-19K15708
  • [Presentation] Toward in vivo gold (III) complex-catalyzed glycosylation for targeting cancer cells2019

    • Author(s)
      Tsung-Che.Chang, Katsunori Tanaka
    • Organizer
      The 18th Asian Chemical Congress and the 20th General Assembly of the Federation of Asian Chemical Societies
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K15708
  • [Presentation] Synthesis and biological applications of glycoconjugates for cancer therapy2019

    • Author(s)
      Tsung-Che.Chang, Katsunori Tanaka
    • Organizer
      RIKEN-Max Planck Joint Research Center for System Chemical Biology the Seventh Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K15708
  • 1.  田中 克典 (00403098)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  永橋 昌幸 (30743918)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  奥田 修二郎 (00512310)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  盛本 浩二 (00599996)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  阿部 学 (10334674)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  三好 康雄 (50283784)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  大村谷 昌樹 (60398229)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  PRADIPTA AMBARA (90631648)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  KABAYAMA Kazuya
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  田村 理
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  吉岡 広大
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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