Sayama Seisuke 佐山晴亮

Researcher Number	00775041
Other IDs	https://orcid.org/0000-0003-0244-6332
Affiliation (Current)	2026: 東京大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help	2024 – 2025: 東京大学, 医学部附属病院, 助教 2022 – 2023: 東京大学, 医学部附属病院, 届出研究員 2019 – 2021: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / 0906:Surgery related to the biological and sensory functions and related fields
Keywords	Principal Investigator 赤血球 / 胎児発育不全 / 妊娠高血圧腎症 / 胎盤 / 妊娠高血圧症候群 / トランスポーター / アミノ酸 / 低酸素 / アミノ酸トランスポーター / 胎盤輸送

胎盤機能不全における赤血球の役割の解明と新規治療法の開発に向けてPrincipal Investigator
- Principal Investigator
  
  佐山晴亮
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  The University of Tokyo
Elucidation of the Molecular Pathophysiology of Placental Dysfunction Focusing on the Oxygen-Carrying Capacity of Red Blood CellsPrincipal Investigator
- Principal Investigator
  
  SAYAMA SEISUKE
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  The University of Tokyo
Elucidating the pathophysiology of placental insufficiency for the novel treatment of the diseasePrincipal Investigator
- Principal Investigator
  
  Sayama Seisuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0906:Surgery related to the biological and sensory functions and related fields
- Research Institution
  The University of Tokyo

All 2025 2024 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Hysteroscopic Endometrial Defect Following Adenomyomectomy and Incidence of Placenta Accreta Spectrum and Uterine Rupture Complications for Subsequent Pregnancy2025
- Author(s)
  Ichinose Mari、Iriyama Takayuki、Hiraike Osamu、Sayama Seisuke、Hashimoto Ayako、Suzuki Kensuke、Matsuo Mitsunori、Toshimitsu Masatake、Seyama Takahiro、Sone Kenbun、Kumasawa Keiichi、Hirota Yasushi、Osuga Yutaka
- Journal Title
  
  Reproductive Sciences
  
  Volume: 32 Issue: 2 Pages: 467-473
- DOI
  10.1007/s43032-024-01758-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18158, KAKENHI-PROJECT-23K15827, KAKENHI-PROJECT-23K15828
[Journal Article] Neurological outcomes and associated perinatal factors in infants born between 22 and 25 weeks with active care2024
- Author(s)
  Ariyoshi Yu、Iriyama Takayuki、Seyama Takahiro、Sayama Seisuke、Yano Eriko、Suzuki Kensuke、Samejima Taiki、Ichinose Mari、Toshimitsu Masatake、Sone Kenbun、Ito Atsushi、Shitara Yoshihiko、Kumasawa Keiichi、Kashima Kohei、Kakiuchi Satsuki、Hirota Yasushi、Takahashi Naoto、Osuga Yutaka
- Journal Title
  
  Journal of Perinatology
  
  Volume: 45 Issue: 2 Pages: 186-193
- DOI
  10.1038/s41372-024-02093-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18158, KAKENHI-PROJECT-23K15828, KAKENHI-PROJECT-24K18876
[Journal Article] The Effects of Low Concentrations of Pravastatin on Placental Cells2024
- Author(s)
  Kanda Masako、Kumasawa Keiichi、Nemoto Kazunari、Miyatake Risa、Inaba Kei、Sayama Seisuke、Seyama Takahiro、Iriyama Takayuki、Nagamatsu Takeshi、Fujii Tomoyuki、Hirota Yasushi、Osuga Yutaka、Kimura Tadashi
- Journal Title
  
  Reproductive Sciences
  
  Volume: 31 Issue: 10 Pages: 3139-3147
- DOI
  10.1007/s43032-024-01611-x
- Data Source
  KAKENHI-PROJECT-20K18158
[Journal Article] Successful Pregnancy Outcome With Preconception Care in a Symptomatic Carrier of Duchenne Muscular Dystrophy: Case Report and Literature Review2024
- Author(s)
  Kinugawa Motoaki、Ichinose Mari、Matsui Haruka、Xiang Zeng、Sayama Seisuke、Toshimitsu Masatake、Seyama Takahiro、Masuda Hitomi、Matsui Hikoro、Kumasawa Keiichi、Iriyama Takayuki、Hirota Yasushi、Osuga Yutaka
- Journal Title
  
  American Journal of Medical Genetics Part A
  
  Volume: 197 Issue: 3 Pages: 186-193
- DOI
  10.1002/ajmg.a.63926
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18158, KAKENHI-PROJECT-23K15828
[Journal Article] Prediction of spontaneous vaginal delivery in the prolonged second stage using the delta angle of progression2024
- Author(s)
  Yano Eriko、Sayama Seisuke、Iriyama Takayuki、Ariyoshi Yu、Akiba Naoya、Ichinose Mari、Toshimitsu Masatake、Seyama Takahiro、Kumasawa Keiichi、Nakayama Toshio、Kobayashi Koichi、Nagamatsu Takeshi、Hirota Yasushi、Osuga Yutaka
- Journal Title
  
  American Journal of Obstetrics & Gynecology MFM
  
  Volume: 6 Issue: 8 Pages: 101403-101403
- DOI
  10.1016/j.ajogmf.2024.101403
- Data Source
  KAKENHI-PROJECT-20K18158
[Journal Article] Proposed Management Policy for Pregnant Women with Loeys-Dietz Syndrome Following Prophylactic Aortic Root Replacement Based on Experience from a Tertiary Care Center2022
- Author(s)
  Sayama Seisuke、Iriyama Takayuki、Takeda Norifumi、Yamauchi Haruo、Toshimitsu Masatake、Seyama Takahiro、Sone Kenbun、Kumasawa Keiichi、Nagamatsu Takeshi、Fujii Tomoyuki、Osuga Yutaka
- Journal Title
  
  Int. Heart J.
  
  Volume: 63 Issue: 1 Pages: 176-179
- DOI
  10.1536/ihj.21-341
- NAID
  130008145710
- ISSN
  1349-2365, 1349-3299
- Year and Date
  2022-01-29
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08484, KAKENHI-PROJECT-20K18158
[Journal Article] The impact of fetal growth restriction in diagnosing preeclampsia on the severity of maternal features2022
- Author(s)
  Kasuya Minori、Akiba Naoya、Iriyama Takayuki、Sayama Seisuke、Kubota Kaori、Toshimitsu Masatake、Seyama Takahiro、Sone Kenbun、Kumasawa Keiichi、Nagamatsu Takeshi、Fujii Tomoyuki、Osuga Yutaka
- Journal Title
  
  Journal of Obstetrics and Gynaecology Research
  
  Volume: 48 Issue: 4 Pages: 912-919
- DOI
  10.1111/jog.15152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K18158, KAKENHI-PROJECT-21K16784
[Journal Article] Pregnancy‐induced hemorrhagic degeneration of adenomyosis2022
- Author(s)
  Nakanishi Megumi、Iriyama Takayuki、Sayama Seisuke、Hanaoka Shouhei、Toshimitsu Masatake、Seyama Takahiro、Sone Kenbun、Kumasawa Keiichi、Nagamatsu Takeshi、Osuga Yutaka
- Journal Title
  
  Journal of Obstetrics and Gynaecology Research
  
  Volume: 48 Issue: 5 Pages: 1265-1270
- DOI
  10.1111/jog.15195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K09442, KAKENHI-PROJECT-20K18158
[Journal Article] Prenatal diagnosis of pyriform sinus fistula using ultrasonography by detecting the communication to the pharynx2022
- Author(s)
  Sayama Seisuke、Iriyama Takayuki、Nakayama Toshio、Seyama Takahiro、Sone Kenbun、Kumasawa Keiichi、Nagamatsu Takeshi、Suzuki Kan、Fujii Tomoyuki、Osuga Yutaka
- Journal Title
  
  Taiwanese Journal of Obstetrics and Gynecology
  
  Volume: 61 Issue: 2 Pages: 385-387
- DOI
  10.1016/j.tjog.2022.02.035
- Data Source
  KAKENHI-PROJECT-20K18158
[Journal Article] Anatomical identification of ischial spines applicable to intrapartum transperineal ultrasound based on magnetic resonance imaging of pregnant women2022
- Author(s)
  Yano Eriko、Iriyama Takayuki、Hanaoka Shouhei、Sayama Seisuke、Ichinose Mari、Toshimitsu Masatake、Seyama Takahiro、Sone Kenbun、Kumasawa Keiichi、Nagamatsu Takeshi、Kobayashi Koichi、Fujii Tomoyuki、Osuga Yutaka
- Journal Title
  
  The Journal of Maternal-Fetal & Neonatal Medicine
  
  Volume: online ahead of print Issue: 25 Pages: 1-6
- DOI
  10.1080/14767058.2022.2051007
- Data Source
  KAKENHI-PROJECT-20K18158
[Journal Article] Elevated placental histone H3K4 methylation via upregulated histone methyltransferases SETD1A and SMYD3 in preeclampsia and its possible involvement in hypoxia-induced pathophysiological process.2021
- Author(s)
  H. Matsui, T. Iriyama, S. Sayama, N. Inaoka, K. Suzuki, M. Yoshikawa, M. Ichinose, K. Sone, K. Kumasawa, T. Nagamatsu, T. Fujisawa, I. Naguro, H. Ichijo, T. Fujii, Y. Osuga
- Journal Title
  
  Placenta
  
  Volume: 115 Pages: 60-69
- DOI
  10.1016/j.placenta.2021.09.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15358, KAKENHI-PROJECT-21H04760, KAKENHI-PROJECT-20H03820, KAKENHI-PROJECT-20K18158
[Journal Article] Postpartum Stanford type B aortic dissection in a woman with Loeys-Dietz syndrome who underwent a prophylactic aortic root replacement before conception: A case report2021
- Author(s)
  Shitara Rieko、Iriyama Takayuki、Sayama Seisuke、Takeda Norifumi、Nagamatsu Takeshi、Osuga Yutaka、Fujii Tomoyuki
- Journal Title
  
  Taiwanese Journal of Obstetrics and Gynecology
  
  Volume: 60 Issue: 1 Pages: 145-147
- DOI
  10.1016/j.tjog.2020.10.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08484, KAKENHI-PROJECT-20K18158
[Journal Article] Role of adenosine signaling in preeclampsia2021
- Author(s)
  Iriyama Takayuki、Sayama Seisuke、Osuga Yutaka
- Journal Title
  
  Journal of Obstetrics and Gynaecology Research
  
  Volume: 48 Issue: 1 Pages: 49-57
- DOI
  10.1111/jog.15066
- Data Source
  KAKENHI-PROJECT-20K18158
[Journal Article] Secretory leukocyte protease inhibitor and progranulin as possible regulators of cervical remodeling in pregnancy2021
- Author(s)
  Samejima Taiki、Nagamatsu Takeshi、Akiba Naoya、Fujii Tatsuya、Sayama Seisuke、Kawana Kei、Taguchi Ayumi、Kumasawa Keiichi、Iriyama Takayuki、Osuga Yutaka、Fujii Tomoyuki
- Journal Title
  
  Journal of Reproductive Immunology
  
  Volume: 143 Pages: 103241-103241
- DOI
  10.1016/j.jri.2020.103241
- Data Source
  KAKENHI-PROJECT-18K09220, KAKENHI-PROJECT-20K09613, KAKENHI-PROJECT-20K18158
[Journal Article] A Fetus with Imperforate Anus Developing Pulmonary Hypoplasia Triggered by Transient Urethral Obstruction.2021
- Author(s)
  Toshimitsu M, Iriyama T, Sayama S, Suzuki K, Kakiuchi S, Ichinose M, Seyama T, Sone K, Kumasawa K, Nagamatsu T, Fujii T, Osuga Y.
- Journal Title
  
  Case Rep Obstet Gynecol.
  
  Volume: - Pages: 9950578-9950578
- DOI
  10.1155/2021/9950578
- Open Access
- Data Source
  KAKENHI-PROJECT-20K09613, KAKENHI-PROJECT-20K18158
[Journal Article] Maternal erythrocyte ENT1?mediated AMPK activation counteracts placental hypoxia and supports fetal growth2020
- Author(s)
  Sayama Seisuke、Song Anren、Brown Benjamin C.、Couturier Jacob、Cai Xiaoli、Xu Ping、Chen Changhan、Zheng Yangxi、Iriyama Takayuki、Sibai Baha、Longo Monica、Kellems Rodney E.、D’Alessandro Angelo、Xia Yang
- Journal Title
  
  JCI Insight
  
  Volume: 5 Issue: 10
- DOI
  10.1172/jci.insight.130205
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18158, KAKENHI-PROJECT-19K24044
[Presentation] 妊娠高血圧腎症の病態生理と子宮腺筋症が及ぼす周産期疾患について2021
- Author(s)
  佐山晴亮
- Organizer
  第36回日本生殖免疫学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K24044
[Presentation] ENT1 mediated maintenance of maternal erythrocytes’ oxygen delivering capacity plays crucial roles in placental oxygenation and adequate fetal growth2020
- Author(s)
  Seisuke Sayama
- Organizer
  日本産婦人科学会
- Data Source
  KAKENHI-PROJECT-19K24044
[Presentation] 胎盤におけるアミノ酸輸送機構と胎児発育2019
- Author(s)
  佐山晴亮
- Organizer
  胎盤学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K24044
[Presentation] Maternal erythrocyte ENT1-mediated oxygen delivery is necessary for adequate placental oxygenation and fetal growth2019
- Author(s)
  Seisuke Sayama
- Organizer
  国際生殖免疫学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K24044
[Presentation] 赤血球の酸素運搬能の低下は、胎盤のアミノ酸輸送機構を阻害し胎児発育不全の発症に関与する2019
- Author(s)
  佐山晴亮
- Organizer
  妊娠高血圧学会
- Data Source
  KAKENHI-PROJECT-19K24044
[Presentation] Maternal erythrocyte ENT1-mediated AMPK activation and oxygen delivery: a missing component counteracting placental hypoxia, dysfunction, and fetal growth restriction.2019
- Author(s)
  Seisuke Sayama
- Organizer
  American society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K24044

1. 入山高行 (10570442)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 熊澤惠一 (90444546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. NAGAMATSU Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 藤澤貴央

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 武田憲文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sayama Seisuke 佐山 晴亮

Research Projects

Research Products

Co-Researchers

胎盤機能不全における赤血球の役割の解明と新規治療法の開発に向けてPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the Molecular Pathophysiology of Placental Dysfunction Focusing on the Oxygen-Carrying Capacity of Red Blood CellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the pathophysiology of placental insufficiency for the novel treatment of the diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Hysteroscopic Endometrial Defect Following Adenomyomectomy and Incidence of Placenta Accreta Spectrum and Uterine Rupture Complications for Subsequent Pregnancy2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neurological outcomes and associated perinatal factors in infants born between 22 and 25 weeks with active care2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Effects of Low Concentrations of Pravastatin on Placental Cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Successful Pregnancy Outcome With Preconception Care in a Symptomatic Carrier of Duchenne Muscular Dystrophy: Case Report and Literature Review2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prediction of spontaneous vaginal delivery in the prolonged second stage using the delta angle of progression2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Proposed Management Policy for Pregnant Women with Loeys-Dietz Syndrome Following Prophylactic Aortic Root Replacement Based on Experience from a Tertiary Care Center2022

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] The impact of fetal growth restriction in diagnosing preeclampsia on the severity of maternal features2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pregnancy‐induced hemorrhagic degeneration of adenomyosis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prenatal diagnosis of pyriform sinus fistula using ultrasonography by detecting the communication to the pharynx2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anatomical identification of ischial spines applicable to intrapartum transperineal ultrasound based on magnetic resonance imaging of pregnant women2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Elevated placental histone H3K4 methylation via upregulated histone methyltransferases SETD1A and SMYD3 in preeclampsia and its possible involvement in hypoxia-induced pathophysiological process.2021

Author(s)

Journal Title

DOI

Sayama Seisuke 佐山晴亮