YOSHIDA Michiharu 吉田道春

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Yoshida Michiharu 吉田道春

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Researcher Number	00795437
Other IDs
Affiliation (Current)	2025: 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員
Affiliation (based on the past Project Information) *help	2021 – 2025: 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Basic Section 56010:Neurosurgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 90130:Medical systems-related
Keywords	Principal Investigator 悪性神経膠腫 / 集束超音波 / 抗体修飾 / リポソーム / 抗癌剤封入リポソーム / mRNA封入脂質ナノ粒子 / ドキソルビシン / 血液脳関門 / 薬物送達治療 / doxorubicin … More / mRNA / drug derivery system / lipid nanoparticles / micro-bubbles / focused ultrasound / glioblastoma / マイクロバブル / 三次元解析 / antibody-modified / テモゾロミド / 脳移植マウス / バブルリポソーム / malignant glioma … More Except Principal Investigator LNP / mRNA / siRNA-LNP / malignant brain tumor / 核酸医薬 / 脳指向薬物送達法 / 脂質ナノ粒子 / 集束超音波 / siRNA / 悪性神経膠腫 / 血液脳関門開口 / 癌治療 / BBBオープニング / DDS / 脳腫瘍 / パーキンソン病 / アルツハイマー病 / 認知症 / 超音波 / マイクロバブル / 血液脳関門 Less

悪性神経膠腫に対する薬剤封入抗体修飾リポソームと脳内薬物動態解析Principal Investigator
- Principal Investigator
  
  吉田道春
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Nagasaki University
The treatment of drug-encapsulated liposomes and the 3D-microimaging of intra-cerebral pharmacokinetics in malignant gliomaPrincipal Investigator
- Principal Investigator
  
  Yoshida Michiharu
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Nagasaki University
悪性神経膠腫に対するsiRNAを使用した核酸医薬導入への挑戦
- Principal Investigator
  
  松尾彩香
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Nagasaki University
Development of a non-invasive delivery method for mRNA drugs for malignant brain tumors
- Principal Investigator
  
  日宇健
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Nagasaki University
The establishment of drug-delivery system and the 3D-microimaging of intra-cerebral pharmacokinetics in malignant gliomaPrincipal Investigator
- Principal Investigator
  
  Yoshida Michiharu
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Nagasaki University
Blood-brain barrier opening and brain drug delivery by lipid bubble and MRI-guided transcranial ultrasound
- Principal Investigator
  
  Maruyama Kazuo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90130:Medical systems-related
- Research Institution
  Teikyo University

All 2025 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] A case of vasa corona ruptured pseudoaneurysm: case report and review of literature2025
- Author(s)
  Nakamura Hikaru、Izumo Tsuyoshi、Okamura Kazuaki、Yoshimura Shota、Ueki Nozomi、Baba Shiro、Ujifuku Kenta、Morofuji Yoichi、Hiu Takeshi、Yoshida Koichi、Matsuo Takayuki
- Journal Title
  
  Acta Neurochirurgica
  
  Volume: 167 Issue: 1
- DOI
  10.1007/s00701-025-06531-6
- Data Source
  KAKENHI-PROJECT-23K08503
[Journal Article] Synthesis of a novel adapter lipid using Fc-region mediated antibody modification for post-insert preparation of transferrin receptor targeted messenger RNA-loaded lipid nanoparticles2024
- Author(s)
  Kato Naoya、Moriya Narumi、Matsumoto Makoto、Matsuo Ayaka、Yoshida Michiharu、Hiu Takeshi、Matsuo Takayuki、Takashima Yuuki、Kamiya Mariko、Mukai Hidefumi、Kawakami Shigeru
- Journal Title
  
  European Journal of Pharmaceutics and Biopharmaceutics
  
  Volume: 203 Pages: 114468-114468
- DOI
  10.1016/j.ejpb.2024.114468
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14620, KAKENHI-PROJECT-23K08503, KAKENHI-PROJECT-23K17479
[Journal Article] Treatment of new-onset primary central nervous system lymphoma in elderly patients using RMPV chemotherapy: a single-institution experience2023
- Author(s)
  Yoshida Michiharu、Kato Takeharu、Hiu Takeshi、Imaizumi Yoshitaka、Morimoto Simpei、Niino Daisuke、Yamaguchi Susumu、Baba Shiro、Ujifuku Kenta、Yoshida Koichi、Matsuo Ayaka、Morofuji Yoichi、Izumo Tsuyoshi、Okano Shinji、Miyazaki Yasushi、Matsuo Takayuki
- Journal Title
  
  International Journal of Hematology
  
  Volume: 118 Issue: 3 Pages: 333-339
- DOI
  10.1007/s12185-023-03632-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20KK0254, KAKENHI-PROJECT-23K06424, KAKENHI-PROJECT-23K08503, KAKENHI-PROJECT-20K09328, KAKENHI-PROJECT-20K09351
[Journal Article] Focused ultrasound/microbubbles-assisted BBB opening enhances LNP-mediated mRNA delivery to brain2022
- Author(s)
  Ogawa Koki、Kato Naoya、Yoshida Michiharu、Hiu Takeshi、Matsuo Takayuki、Mizukami Shusaku、Omata Daiki、Suzuki Ryo、Maruyama Kazuo、Mukai Hidefumi、Kawakami Shigeru
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 348 Pages: 34-41
- DOI
  10.1016/j.jconrel.2022.05.042
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09328, KAKENHI-PROJECT-22K12849, KAKENHI-PROJECT-20H04519, KAKENHI-PROJECT-20H04542, KAKENHI-PROJECT-20H04554, KAKENHI-PROJECT-21H03818, KAKENHI-PROJECT-20J21334, KAKENHI-PROJECT-21K15554
[Presentation] Evaluation of MRI APT CEST Imaging for Therapeutic Intervention in Asymptomatic Meningiomas2024
- Author(s)
  Takeshi Hiu, Hirofumi Koike, Shiro Baba, Kenta Ushifuku, Yoichi Morofuji, Koichi Yoshida, Takayuki Matsuo
- Organizer
  16th Young-Honam and Kyushu Neurosurgical Joint Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K08503
[Presentation] 悪性神経膠腫に対するmRNA封入脂質ナノ粒子の開発2024
- Author(s)
  日宇健, 松尾彩香, 神谷万里子, 松本眞, 吉田道春, 中村光流, 馬場史郎, 川上茂, 松尾孝之
- Organizer
  第42回日本脳腫瘍学会学術集会プログラム
- Data Source
  KAKENHI-PROJECT-23K08503
[Presentation] 無症候性髄膜腫の新たな治療指針-MRI APT CESTイメージングによる腫瘍増大予測2024
- Author(s)
  日宇健, 馬場史郎, 氏福健太, 吉田光一, 諸藤陽一,出雲剛, 松尾孝之
- Organizer
  日本脳神経外科学会第83回学術総会
- Data Source
  KAKENHI-PROJECT-23K08503
[Presentation] 頭蓋底髄膜腫の治療成績2024
- Author(s)
  日宇健、馬場史郎、氏福健太、吉田光一、諸藤陽一、松尾孝之
- Organizer
  第36回日本頭蓋底外科学会
- Data Source
  KAKENHI-PROJECT-23K08503
[Presentation] Fc領域結合ペプチド修飾脂質の設計・合成と抗体修飾脂質ナノ粒子の開発2023
- Author(s)
  松本眞, 松尾彩香, 森谷成美, 加藤直也, 神谷万里子, 吉田道春, 日宇健, 松尾孝之, 川上茂
- Organizer
  第66回日本脳循環代謝学会
- Data Source
  KAKENHI-PROJECT-23K08503
[Presentation] ペプチド脂質修飾mRNA封入脂質ナノ粒子の腫瘍内投与における発現特性の評価2023
- Author(s)
  神谷万里子, 日宇健, 大野海晴, 松尾彩香, 松本眞, 吉田道春, 松尾孝之, 川上茂
- Organizer
  第66回脳循環代謝学会
- Data Source
  KAKENHI-PROJECT-23K14620
[Presentation] 新規Fc領域結合ペプチド修飾脂質を用いる脳腫瘍を標的とした抗体修飾脂質ナノ粒子の開発2023
- Author(s)
  松本眞, 松尾彩香, 森谷成美, 吉田道春, 日宇健, 神谷万里子, 松尾孝之, 川上茂
- Organizer
  第66回脳循環代謝学会
- Data Source
  KAKENHI-PROJECT-23K14620
[Presentation] 集束超音波とマイクロバブルによるmRNA封入脂質ナノ粒子の脳内送達の研究2022
- Author(s)
  吉田道春, 小川昂輝, 加藤直也, 日宇健, 水上修作, 小俣大樹, 鈴木亮, 丸山一雄, 川上茂, 松尾孝之
- Organizer
  第39回日本脳腫瘍学会学術総集会
- Data Source
  KAKENHI-PROJECT-21K15554
[Presentation] 集束超音波とマイクロバブルによるmRNA封入脂質ナノ粒子の脳内送達の研究2021
- Author(s)
  吉田道春、小川昂輝、加藤直也、日宇健、水上修作、小俣大樹、鈴木亮、丸山一雄、川上茂、松尾孝之
- Organizer
  第39回日本脳腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-21K15554
[Presentation] 集束超音波とマイクロバブルによるmRNA封入脂質ナノ粒子の脳内送達の研究2021
- Author(s)
  吉田道春、小川昂輝、加藤直也、日宇健、水上修作、小俣大樹、鈴木亮、丸山一雄、川上茂、松尾孝之
- Organizer
  第39回日本脳腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-20H04554
[Presentation] リピッドバブルと経頭蓋集束超音波を用いたBBBオープニングによる薬物送達2020
- Author(s)
  丸山一雄、吉田道春、加藤容崇、小俣大樹、鈴木亮
- Organizer
  第36回日本DDS学会
- Data Source
  KAKENHI-PROJECT-20H04554
[Presentation] リピッドバブルとヒト用経頭蓋集束超音波装置を用いたBBBオープニングによる薬物送達に関する基礎研究2020
- Author(s)
  丸山一雄、吉田道春、加藤容崇、小俣大樹、鈴木亮
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-20H04554
[Presentation] リピッドバブルと220kHz経頭蓋MRIガイド集束超音波を用いた血液脳関門開通の研究2020
- Author(s)
  丸山一雄、吉田道春、加藤容崇、小俣大樹、鈴木亮、Rachmilevitch Itay、鈴木秀二、鎌田一
- Organizer
  日本超音波医学会第93回学術集会
- Data Source
  KAKENHI-PROJECT-20H04554

1. 松尾孝之 (00274655)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. 日宇健 (00404260)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
3. 川上茂 (20322307)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. 松尾彩香 (80913342)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
5. Maruyama Kazuo (30130040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 梅村晋一郎 (20402787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 吉澤晋 (30455802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 小俣大樹 (80803113)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. 吉田光一 (20393457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
10. 氏福健太 (20437867)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. 馬場史郎 (30530430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
12. 諸藤陽一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YOSHIDA Michiharu 吉田 道春

Yoshida Michiharu 吉田 道春

Research Projects

Research Products

Co-Researchers

悪性神経膠腫に対する薬剤封入抗体修飾リポソームと脳内薬物動態解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The treatment of drug-encapsulated liposomes and the 3D-microimaging of intra-cerebral pharmacokinetics in malignant gliomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

悪性神経膠腫に対するsiRNAを使用した核酸医薬導入への挑戦

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a non-invasive delivery method for mRNA drugs for malignant brain tumors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The establishment of drug-delivery system and the 3D-microimaging of intra-cerebral pharmacokinetics in malignant gliomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Blood-brain barrier opening and brain drug delivery by lipid bubble and MRI-guided transcranial ultrasound

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] A case of vasa corona ruptured pseudoaneurysm: case report and review of literature2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of a novel adapter lipid using Fc-region mediated antibody modification for post-insert preparation of transferrin receptor targeted messenger RNA-loaded lipid nanoparticles2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Treatment of new-onset primary central nervous system lymphoma in elderly patients using RMPV chemotherapy: a single-institution experience2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Focused ultrasound/microbubbles-assisted BBB opening enhances LNP-mediated mRNA delivery to brain2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] Evaluation of MRI APT CEST Imaging for Therapeutic Intervention in Asymptomatic Meningiomas2024

Author(s)

Organizer

Data Source

[Presentation] 悪性神経膠腫に対するmRNA封入脂質ナノ粒子の開発2024

Author(s)

Organizer

Data Source

[Presentation] 無症候性髄膜腫の新たな治療指針-MRI APT CESTイメージングによる腫瘍増大予測2024

Author(s)

Organizer

Data Source

[Presentation] 頭蓋底髄膜腫の治療成績2024

Author(s)

Organizer

Data Source

[Presentation] Fc領域結合ペプチド修飾脂質の設計・合成と抗体修飾脂質ナノ粒子の開発2023

Author(s)

Organizer

YOSHIDA Michiharu 吉田道春

Yoshida Michiharu 吉田道春