Arisawa Kotoko 有澤琴子

… Alternative Names

有澤琴子アリサワコトコ

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Researcher Number	00813122
Other IDs
Affiliation (Current)	2025: 東北大学, 薬学研究科, 助教
Affiliation (based on the past Project Information) *help	2021 – 2024: 東北大学, 薬学研究科, 助教 2020: お茶の水女子大学, 生活科学部, アカデミック・アシスタント 2018: 日本医科大学, 大学院医学研究科, ポストドクター
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Complex systems / 0108:Sociology and related fields / Basic Section 38050:Food sciences-related Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields
Keywords	Principal Investigator NASH / 鉄 / フェロトーシス / セレン / 酸化ストレス / 生体膜 / 飽和脂肪酸 / 酸化コレステロール / 肝臓 / セレノプロテインP … More / 脂質 / 糖尿病 / 脂肪酸 / 肝障害 / 飽和脂肪酸毒性 / 小胞体ストレス / 脂肪毒性 … More Except Principal Investigator セレノプロテイン / レドックス制御 / メタロミクス / 酸性化 / ライソゾーム / 分泌タンパク質 / 疾患予防 / 慢性疾患 / lncRNA / スルフォラフェン / NRF2 / 発現制御 / 2型糖尿病 / セレノプロテインＰ / 重金属 / コホート研究 / 転写因子 / ICP-MS / 地域住民コホート / インスリン抵抗性 / インスリン分泌 / メチル水銀 / 亜鉛 / がん / 生活習慣病 / セレン Less

セレン輸送体による新たな鉄代謝制御システムの解明と肝疾患治療への応用Principal Investigator
- Principal Investigator
  
  有澤琴子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tohoku University
Elucidation of the molecular pathology of chronic diseases and establishment of new treatment methods based on trace element research
- Principal Investigator
  
  斎藤芳郎
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Tohoku University
Elucidation of the direct metabolic control mechanisms of producing cells by secreted proteins
- Principal Investigator
  
  斎藤芳郎
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Tohoku University
Mechanisms of liver disease pathogenesis based on selenium homeostasis in the liverPrincipal Investigator
- Principal Investigator
  
  有澤琴子
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tohoku University
Mechanisms of Metabolic Disease Exacerbation through Regulation of Biological Membrane Lipid Composition by Oxidized CholesterolPrincipal Investigator
- Principal Investigator
  
  Arisawa Kotoko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tohoku University
Mechanism of exacerbation of nonalcoholic fatty liver disease by the interaction of animal lipid componentsPrincipal Investigator
- Principal Investigator
  
  Arisawa Kotoko
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0108:Sociology and related fields
- Research Institution
  Tohoku University
  Ochanomizu University
Regulatory mechanism of selenoprotein P expression and its deterioration mechanism of glucose metabolism
- Principal Investigator
  
  Saito Yoshiro
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Tohoku University
低タンパク質栄養状態ラットを用いた褐色脂肪組織の白色化機構の解明Principal Investigator
- Principal Investigator
  
  有澤琴子
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Nippon Medical School

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Selenoprotein P expression in glioblastoma as a regulator of ferroptosis sensitivity: preservation of GPX4 via the cycling-selenium storage2024
- Author(s)
  Zheng Xi、Toyama Takashi、Siu Stephanie、Kaneko Takayuki、Sugiura Hikari、Yamashita Shota、Shimoda Yoshiteru、Kanamori Masayuki、Arisawa Kotoko、Endo Hidenori、Saito Yoshiro
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 682-682
- DOI
  10.1038/s41598-024-51259-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-22H04796, KAKENHI-ORGANIZER-21H05258, KAKENHI-PROJECT-23K28236
[Journal Article] Sulforaphane decreases serum selenoprotein P levels through enhancement of lysosomal degradation independent of Nrf22023
- Author(s)
  Ye Xinying、Toyama Takashi、Taguchi Keiko、Arisawa Kotoko、Kaneko Takayuki、Tsutsumi Ryouhei、Yamamoto Masayuki、Saito Yoshiro
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 1060-1060
- DOI
  10.1038/s42003-023-05449-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-22H04796, KAKENHI-ORGANIZER-21H05258, KAKENHI-PROJECT-23K28236
[Journal Article] ダイナミクスと生理／病理的意義，重金属毒性に対する作用2023
- Author(s)
  有澤琴子、外山喬士、斎藤芳郎
- Journal Title
  
  Farumashia
  
  Volume: 59 Issue: 3 Pages: 179-184
- DOI
  10.14894/faruawpsj.59.3_179
- ISSN
  0014-8601, 2189-7026
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-21K17680, KAKENHI-PUBLICLY-22H04796
[Journal Article] GPER/PKA-Dependent Enhancement of Hormone-Sensitive Lipase Phosphorylation in 3T3-L1 Adipocytes by Piceatannol2023
- Author(s)
  Arisawa Kotoko、Matsuoka Ayumi、Ozawa Natsuki、Ishikawa Tomoko、Ichi Ikuyo、Fujiwara Yoko
- Journal Title
  
  Nutrients
  
  Volume: 16 Issue: 1 Pages: 38-38
- DOI
  10.3390/nu16010038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K17680
[Journal Article] An efficient selenium transport pathway of selenoprotein P?utilizing a high-affinity ApoER2 receptor variant and being independent of selenocysteine lyase2023
- Author(s)
  Mizuno Ayako、Toyama Takashi、Ichikawa Atsuya、Sakai Naoko、Yoshioka Yuya、Nishito Yukina、Toga Renya、Amesaka Hiroshi、Kaneko Takayuki、Arisawa Kotoko、Tsutsumi Ryouhei、Mita Yuichiro、Tanaka Shun-ichi、Noguchi Noriko、Saito Yoshiro
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 8 Pages: 105009-105009
- DOI
  10.1016/j.jbc.2023.105009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06606, KAKENHI-PROJECT-21K05386, KAKENHI-PROJECT-21K15262, KAKENHI-PUBLICLY-22H04796, KAKENHI-ORGANIZER-21H05258, KAKENHI-PUBLICLY-22H05579, KAKENHI-PUBLICLY-23H04559
[Journal Article] Effects of the Interplay between Selenocystine and Methylmercury on Their Cytotoxicity and Glucose-Driven Insulin Secretion from Mouse Insulinoma Cells2022
- Author(s)
  Chida Daichi、Toyama Takashi、Chiba Takanori、Kaneko Takayuki、Arisawa Kotoko、Saito Yoshiro
- Journal Title
  
  BPB Reports
  
  Volume: 5 Issue: 4 Pages: 74-79
- DOI
  10.1248/bpbreports.5.4_74
- ISSN
  2434-432X
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22H04796
[Journal Article] Role of selenoprotein P expression in the function of pancreatic β cells: Prevention of ferroptosis-like cell death and stress-induced nascent granule degradation2022
- Author(s)
  Kitabayashi Nanako、Nakao Shohei、Mita Yuichiro、Arisawa Kotoko、Hoshi Takayuki、Toyama Takashi、Ishii Kiyo-aki、Takamura Toshinari、Noguchi Noriko、Saito Yoshiro
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 183 Pages: 89-103
- DOI
  10.1016/j.freeradbiomed.2022.03.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11770, KAKENHI-PROJECT-17H04199, KAKENHI-PROJECT-18K08507, KAKENHI-PROJECT-21K08573, KAKENHI-PROJECT-22K06606, KAKENHI-PUBLICLY-22H05579, KAKENHI-PUBLICLY-22H04796, KAKENHI-PROJECT-21K19321, KAKENHI-PLANNED-21H05270, KAKENHI-PROJECT-20H00488
[Journal Article] 鉄依存的な脂質酸化を伴う細胞死フェロトーシスに対するセレン・ビタミンEの作用 : 新たなプログラム細胞死フェロトーシスのメカニズム2022
- Author(s)
  有澤琴子、斎藤芳郎
- Journal Title
  
  化学と生物
  
  Volume: 60 Pages: 573-580
- Data Source
  KAKENHI-PUBLICLY-22H04796
[Journal Article] Metal-binding properties of selenoprotein P—its relation to structure and function2022
- Author(s)
  Takashi Toyama , Takayuki Kaneko , Kotoko Arisawa , Yoshiro Saito
- Journal Title
  
  Metallomics Research
  
  Volume: 2 Issue: 3 Pages: rev-18-rev-27
- DOI
  10.11299/metallomicsresearch.MR202209
- ISSN
  2436-5173
- Year and Date
  2022-12-26
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22H04796
[Journal Article] 鉄依存的な脂質酸化を伴う細胞死フェロトーシスに対するセレン・ビタミンEの作用 : 新たなプログラム細胞死フェロトーシスのメカニズム2022
- Author(s)
  有澤琴子、斎藤芳郎
- Journal Title
  
  化学と生物
  
  Volume: 60 Pages: 573-580
- Data Source
  KAKENHI-PROJECT-21K17680
[Presentation] ビタミンEによるリソソームを介した鉄代謝制御とフェロトーシスの関連2024
- Author(s)
  有澤琴子、斎藤芳郎
- Organizer
  第33回ビタミンE 研究会
- Data Source
  KAKENHI-PUBLICLY-22H04796
[Presentation] セレン輸送タンパク質Selenoprotein Pを介した肝セレン動態およびフェロトーシスの制御2024
- Author(s)
  有澤琴子、平沼哲太、金子尚志、外山喬士、斎藤芳郎
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PUBLICLY-22H04796
[Presentation] 生命金属科学最終報告会：肝臓のセレンホメオスタシスに基づく肝疾患発症機序の解明2024
- Author(s)
  有澤琴子
- Organizer
  生命金属科学　最終成果報告会
- Data Source
  KAKENHI-PUBLICLY-22H04796
[Presentation] 肝細胞癌におけるセレノプロテインP発現変動の意義2024
- Author(s)
  有澤琴子、平沼哲太、金子尚志、外山喬士、斎藤芳郎
- Organizer
  第７回日本セレン研究会
- Data Source
  KAKENHI-PUBLICLY-22H04796
[Presentation] Gタンパク質共役エストロゲン受容体の活性化を介したピセアタンノールの抗肥満効果2024
- Author(s)
  有澤琴子、松岡愛弓、小澤菜月、市育代、藤原葉子
- Organizer
  2024年度日本農芸化学会東京大会
- Data Source
  KAKENHI-PROJECT-21K17680
[Presentation] ビタミンEによるリソソームを介した鉄代謝制御とフェロトーシスの関連2024
- Author(s)
  有澤琴子、斎藤芳郎
- Organizer
  第33回ビタミンE 研究会
- Data Source
  KAKENHI-PROJECT-21K17680
[Presentation] セレン含有タンパク質Selenoprotein Pによるリソソーム内レドックス制御機構の解明2023
- Author(s)
  有澤琴子、外山喬士、斎藤芳郎
- Organizer
  メタルバイオサイエンス研究会2023
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04796
[Presentation] フェロトーシスにおける脂質酸化過程と細胞内局在の解析2023
- Author(s)
  秋場湧太、金子尚志、有澤琴子、斎藤芳郎
- Organizer
  酸化脂質研究会
- Data Source
  KAKENHI-PROJECT-21K17680
[Presentation] フェロトーシスにおける脂質酸化プロセスとCYP7A1の役割2023
- Author(s)
  秋場湧太、金子尚志、有澤琴子、斎藤芳郎
- Organizer
  第22回次世代を担う若手のためのファーマ・バイオフォーラム2023
- Data Source
  KAKENHI-PROJECT-21K17680
[Presentation] フェロトーシスにおける脂質酸化過程とCYP7A1の役割2023
- Author(s)
  秋場湧太、金子尚志、有澤琴子、外山喬士、斎藤芳郎
- Organizer
  第一回生体金属討論会
- Data Source
  KAKENHI-PROJECT-21K17680
[Presentation] 肝臓のセレンホメオスタシスに基づく肝疾患発症機序の解明2023
- Author(s)
  有澤琴子
- Organizer
  生命金属科学第8回地方巡業
- Data Source
  KAKENHI-PUBLICLY-22H04796
[Presentation] フェロトーシスで誘導される脂質酸化メカニズムと細胞小器官局在性2023
- Author(s)
  秋場湧太、金子尚志、有澤琴子、斎藤芳郎
- Organizer
  第65回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-21K17680
[Presentation] リソソーム活性調節における超硫黄分子とセレノプロテインPの役割2023
- Author(s)
  池田峻也、有澤琴子、外山喬士、斎藤芳郎
- Organizer
  第62回日本薬学会東北支部会
- Data Source
  KAKENHI-PUBLICLY-22H04796
[Presentation] セレン輸送タンパク質セレノプロテインPを介した肝臓の金属動態調節と肝疾患制御2023
- Author(s)
  有澤琴子
- Organizer
  第96回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04796
[Presentation] セレン輸送タンパク質セレノプロテインPは受容体ApoER2とともに細胞内セレン貯蔵に関与する2023
- Author(s)
  市川敦也、外山喬士、有澤琴子、斎藤芳郎
- Organizer
  フォーラム2023：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PUBLICLY-22H04796
[Presentation] 炎症に伴うセレン代謝リプログラミング機構の解析2023
- Author(s)
  髙島隼人、菅原麻友美、有澤琴子、金子尚志、外山喬士，斎藤芳郎
- Organizer
  フォーラム2023：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PUBLICLY-22H04796
[Presentation] Selenoprotein P regulates resistance to iron-dependent cell death by modulating selenium homeostasis in hepatocytes2022
- Author(s)
  Kotoko Arisawa, Moeka Natori, Yoshiro Saito
- Organizer
  the 22nd International Congress of Nutrition－the International Union of Nutritional Sciences (the 22nd IUNS-ICN）
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04796
[Presentation] フェロトーシスで惹起される脂質酸化メカニズムの解析2022
- Author(s)
  秋場湧太、金子尚志、有澤琴子、斎藤芳郎
- Organizer
  第61回日本薬学会東北支部会
- Data Source
  KAKENHI-PROJECT-21K17680
[Presentation] Vitamin E increases lysosomal Fe (II) production in hepatocytes despite being protective against ferroptosis2022
- Author(s)
  Kotoko Arisawa, Moeka Natori, Yoshiro Saito
- Organizer
  The 8th International Symposium on Metallomics(ISM-8)
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04796
[Presentation] 肝臓のフェロトーシス感受性におけるセレノプロテインP発現の意義2022
- Author(s)
  名取萌花、有澤琴子、斎藤芳郎
- Organizer
  第21回・次世代を担う若手のためのファーマ・バイオフォーラム2022
- Data Source
  KAKENHI-PUBLICLY-22H04796
[Presentation] Vitamin E increases lysosomal Fe (II) production in hepatocytes despite being protective against ferroptosis2022
- Author(s)
  Kotoko Arisawa, Moeka Natori, Yoshiro Saito
- Organizer
  The 8th International Symposium on Metallomics(ISM-8)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K17680
[Presentation] Vitamin E increases lysosomal Fe2+ concentrations despite preventing lipid peroxidation in hepatocytes2022
- Author(s)
  Kotoko Arisawa, Moeka Natori, Yoshiro Saito
- Organizer
  Iron, Reactive Oxygen Species & Ferroptosis in Life, Death & Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04796
[Presentation] 肝細胞におけるフェロトーシス誘導に対するビタミンEの作用点－リソソーム酸性化および鉄代謝への影響2022
- Author(s)
  斎藤芳郎、有澤琴子、名取萌花
- Organizer
  第32回ビタミンE 研究会
- Data Source
  KAKENHI-PUBLICLY-22H04796
[Presentation] アルコール投与マウスにおけるSelenoprotein Pおよび生命金属動態の解析2022
- Author(s)
  増田あん、有澤琴子、斎藤芳郎
- Organizer
  メタルバイオサイエンス研究会2022
- Data Source
  KAKENHI-PUBLICLY-22H04796
[Presentation] 炎症性マクロファージにおけるセレノプロテインPのセレン供給作用の低下およびリソソーム酸性化の亢進2022
- Author(s)
  菅原麻友美、有澤琴子、斎藤芳郎
- Organizer
  フォーラム2022：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PUBLICLY-22H04796
[Presentation] 肝臓のセレンホメオスタシスに基づく肝疾患発症機序の解明2022
- Author(s)
  有澤琴子
- Organizer
  令和４年度第一回領域会議第１回生命金属科学シンポジウム
- Data Source
  KAKENHI-PUBLICLY-22H04796
[Presentation] Vitamin E increases lysosomal Fe2+ concentrations despite preventing lipid peroxidation in hepatocytes2022
- Author(s)
  Kotoko Arisawa, Moeka Natori, Yoshiro Saito
- Organizer
  Iron, Reactive Oxygen Species & Ferroptosis in Life, Death & Diseasec
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K17680
[Presentation] 炎症性マクロファージにおけるセレン供給作用の低下と超硫黄分子の炎症制御の関連2022
- Author(s)
  有澤琴子、菅原麻友美、斎藤芳郎
- Organizer
  硫黄生物学　第2回領域会議
- Data Source
  KAKENHI-PUBLICLY-22H04796
[Presentation] 25-hydroxycholesterolは肝細胞における飽和脂肪酸毒性を増強させる2021
- Author(s)
  有澤琴子
- Organizer
  日本農芸化学会2021年度仙台大会
- Data Source
  KAKENHI-PROJECT-20K22165

1. Saito Yoshiro (70357060)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 外山喬士 (50720918)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 金子尚志 (20907993)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 三田雄一郎 (70609122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 堤良平 (50435872)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 種村健太郎 (20332322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Arisawa Kotoko 有澤 琴子

有澤 琴子 アリサワ コトコ

Research Projects

Research Products

Co-Researchers

セレン輸送体による新たな鉄代謝制御システムの解明と肝疾患治療への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the molecular pathology of chronic diseases and establishment of new treatment methods based on trace element research

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the direct metabolic control mechanisms of producing cells by secreted proteins

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of liver disease pathogenesis based on selenium homeostasis in the liverPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of Metabolic Disease Exacerbation through Regulation of Biological Membrane Lipid Composition by Oxidized CholesterolPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of exacerbation of nonalcoholic fatty liver disease by the interaction of animal lipid componentsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulatory mechanism of selenoprotein P expression and its deterioration mechanism of glucose metabolism

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

低タンパク質栄養状態ラットを用いた褐色脂肪組織の白色化機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Selenoprotein P expression in glioblastoma as a regulator of ferroptosis sensitivity: preservation of GPX4 via the cycling-selenium storage2024

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[Journal Article] Sulforaphane decreases serum selenoprotein P levels through enhancement of lysosomal degradation independent of Nrf22023

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[Journal Article] ダイナミクスと生理／病理的意義，重金属毒性に対する作用2023

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[Journal Article] GPER/PKA-Dependent Enhancement of Hormone-Sensitive Lipase Phosphorylation in 3T3-L1 Adipocytes by Piceatannol2023

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[Journal Article] An efficient selenium transport pathway of selenoprotein P?utilizing a high-affinity ApoER2 receptor variant and being independent of selenocysteine lyase2023

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Arisawa Kotoko 有澤琴子

有澤琴子アリサワコトコ

[Presentation] セレン輸送タンパク質Selenoprotein Pを介した肝セレン動態およびフェロトーシスの制御2024