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Tsutsumi Ryohei  堤 良平

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Tsutsumi Ryouhei  堤 良平

TSUTSUMI Ryohei  堤 良平

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Researcher Number 50435872
Other IDs
Affiliation (Current) 2025: 北里大学, 医学部, 講師
Affiliation (based on the past Project Information) *help 2022 – 2024: 北里大学, 医学部, 講師
2023: 東北大学, 薬学研究科, 助教
2020 – 2021: 東北大学, 薬学研究科, 講師
2018 – 2020: 東北大学, 薬学研究科, 助教
2014: 東京大学, 大学院医学系研究科, 助教
2012: 東京大学, 医学(系)研究科(研究院), 助教
2010 – 2011: 東京大学, 大学院・医学系研究科, 助教
Review Section/Research Field
Principal Investigator
Basic Section 50010:Tumor biology-related / Basic Section 44010:Cell biology-related / 0802:Biomedical structure and function and related fields / Tumor biology
Except Principal Investigator
Medium-sized Section 47:Pharmaceutical sciences and related fields / Biological Sciences
Keywords
Principal Investigator
細胞内小胞 / 増殖因子 / 細胞内情報伝達 / 解糖系 / 受容体エンドサイトーシス / 情報伝達 / エンドサイトーシス / 細胞等代謝 / 細胞膜受容体 / レドックスシグナル … More / シグナル伝達 / プロテオミクス / タンパク質翻訳後修飾 / パーチオサルフェン化 / 細胞増殖因子 / ホスファターゼ / parafibromin / SHP2 / チロシンホスファターゼ / がん … More
Except Principal Investigator
セレノプロテイン / セレノプロテインP / インスリン抵抗性 / インスリン分泌 / がん / lncRNA / スルフォラフェン / NRF2 / 発現制御 / 2型糖尿病 / 重金属 / コホート研究 / 転写因子 / ICP-MS / 地域住民コホート / メチル水銀 / 亜鉛 / 生活習慣病 / セレン / メタロミクス / 網羅的解析 / 抗酸化システム / 活性酸素種 / レドックス制御 / 骨格筋 / 硫黄代謝 / セレン代謝 / 小胞体ストレス / 膵β細胞 / セレノプロテインP / 還元ストレス / シグナル伝達 / 細菌 / 癌 / 炎症 / ヘリコバクター・ピロリ / 胃がん / 感染症 Less
  • Research Projects

    (7 results)
  • Research Products

    (23 results)
  • Co-Researchers

    (14 People)
  •  Clarification of ALK endocytosis-dependent regulation of glucose metabolism in neuroblastomaPrincipal Investigator

    • Principal Investigator
      堤 良平
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Kitasato University
  •  Evaluation of molecular bases for signal transduction by "signaling endosomes"Principal Investigator

    • Principal Investigator
      Tsutsumi Ryouhei
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 44010:Cell biology-related
    • Research Institution
      Kitasato University
      Tohoku University
  •  Regulatory mechanism of selenoprotein P expression and its deterioration mechanism of glucose metabolism

    • Principal Investigator
      Saito Yoshiro
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      Tohoku University
  •  Omics analysis for the establishment of "reductive stress," a biological disorder caused by excessive antioxidant and reductive environment

    • Principal Investigator
      Saito Yoshiro
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      Tohoku University
  •  Clarification of molecular bases for signal transduction by "signaling endosomes"Principal Investigator

    • Principal Investigator
      Tsutsumi Ryouhei
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Review Section
      0802:Biomedical structure and function and related fields
    • Research Institution
      Tohoku University
  •  Host response as an enhancer of infection-associated cancer and its regulation

    • Principal Investigator
      HATAKEYAMA Masanori
    • Project Period (FY)
      2010 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Molecular mechanism of solid tumor formation by oncogenic tyrosine phosphatase SHP2Principal Investigator

    • Principal Investigator
      TSUTSUMI Ryohei
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Tumor biology
    • Research Institution
      The University of Tokyo

All 2024 2023 2020 2019 2018 2014 2013 2012 2011

All Journal Article Presentation Book

  • [Book] Hippo経路のエフェクター分子YAPおよびTAZによるがんタンパク質SHP2の機能制御2014

    • Author(s)
      高橋 昌史、堤 良平、畠山 昌則
    • Publisher
      細胞工学
    • Data Source
      KAKENHI-PLANNED-22114002
  • [Journal Article] Endocytic vesicles act as vehicles for glucose uptake in response to growth factor stimulation2024

    • Author(s)
      Tsutsumi Ryouhei、Ueberheide Beatrix、Liang Feng-Xia、Neel Benjamin G.、Sakai Ryuichi、Saito Yoshiro
    • Journal Title

      Nature Communications

      Volume: 15 Issue: 1 Pages: 1-15

    • DOI

      10.1038/s41467-024-46971-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07105, KAKENHI-PROJECT-20K06633
  • [Journal Article] Selenoprotein P; P for Plasma, Prognosis, Prophylaxis, and More2020

    • Author(s)
      Tsutsumi Ryouhei、Saito Yoshiro
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 43 Issue: 3 Pages: 366-374

    • DOI

      10.1248/bpb.b19-00837

    • NAID

      130007804438

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2020-03-01
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K21238, KAKENHI-PROJECT-19K22480, KAKENHI-PROJECT-17H03821
  • [Journal Article] Polysulfide stabilization by tyrosine and hydroxyphenyl-containing derivatives that is important for a reactive sulfur metabolomics analysis.2019

    • Author(s)
      Hamid HA, Tanaka A, Ida T, Nishimura A, Matsunaga T, Fujii S, Morita M, Sawa T, Fukuto JM, Nagy P, Tsutsumi R, Motohashi H, Ihara H, Akaike T.
    • Journal Title

      Redox Biol

      Volume: 21 Pages: 101096-101096

    • DOI

      10.1016/j.redox.2019.101096

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07099, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-16H04674, KAKENHI-PROJECT-18H02098, KAKENHI-PROJECT-19K21238, KAKENHI-PROJECT-17F17116, KAKENHI-PROJECT-17K19205, KAKENHI-PROJECT-17K19508, KAKENHI-PROJECT-17K15408, KAKENHI-INTERNATIONAL-15K21759, KAKENHI-PROJECT-19K07554, KAKENHI-PUBLICLY-18H04794, KAKENHI-PROJECT-18H02621, KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-17H06170
  • [Journal Article] Off-target inhibition by active site-targeting SHP2 inhibitors.2018

    • Author(s)
      Tsutsumi R, Ran H, Neel BG
    • Journal Title

      FEBS Open Bio

      Volume: 8 Issue: 9 Pages: 1405-1411

    • DOI

      10.1002/2211-5463.12493

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K21238
  • [Journal Article] YAP and TAZ, Hippo signaling targets, act as a rheostat for nuclear SHP2 function.2013

    • Author(s)
      Tsutsumi, D., Masoodi, M., Takahashi, A., Fujii, Y., Hayashi, T, . Kikuchi, I., et al.
    • Journal Title

      Developmental Cell

      Volume: 26(6) Issue: 6 Pages: 658-665

    • DOI

      10.1016/j.devcel.2013.08.013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J04126, KAKENHI-ORGANIZER-22114001, KAKENHI-PLANNED-22114002, KAKENHI-PROJECT-24700965, KAKENHI-PROJECT-25250016, KAKENHI-PROJECT-25251026
  • [Journal Article] SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver2011

    • Author(s)
      Takahashi A.、Tsutsumi R.、Kikuchi I.、 Obuse C.、Saito Y.、Seidi A.、Karisch R.、 Fernandez M.、Cho T.、Ohnishi N.、 Rozenblatt-Rosen O.、Meyerson M.、Neel B.G.、Hatakeyama M.
    • Journal Title

      Molecular cell

      Volume: 43(1) Issue: 1 Pages: 45-56

    • DOI

      10.1016/j.molcel.2011.05.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20114006, KAKENHI-ORGANIZER-22114001, KAKENHI-PLANNED-22114002, KAKENHI-PROJECT-22240085, KAKENHI-PROJECT-22700877
  • [Presentation] 増殖因子受容体エンドサイトーシスによる細胞ブドウ糖代謝制御2023

    • Author(s)
      堤良平、堺隆一、斎藤芳郎
    • Organizer
      第96回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-20K06633
  • [Presentation] 増殖因子による細胞糖代謝制御の 新たな分子基盤2020

    • Author(s)
      堤良平
    • Organizer
      第93回 日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-20K06633
  • [Presentation] Spatio-temporal regulation of protein tyrosine phosphatases by reactive oxygen Species (ROS) and its pharmaceutical application2020

    • Author(s)
      堤良平
    • Organizer
      第43回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K06633
  • [Presentation] Specific visualization of reversibly oxidized proteins2019

    • Author(s)
      Ryouhei Tsutsumi, Benjamin G. Neel, Yoshiro Saito
    • Organizer
      9th SFRR Asia Biennial Meeting 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K21238
  • [Presentation] 可逆的酸化タンパク質の特異的可視化法の開発2019

    • Author(s)
      堤 良平, Benjamin G. Neel, 斎藤芳郎
    • Organizer
      第72回日本酸化ストレス学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K21238
  • [Presentation] 増殖因子刺激による活性酸素種産生性細胞内小胞の生成2019

    • Author(s)
      堤 良平
    • Organizer
      日本生化学会東北支部第85回例会
    • Data Source
      KAKENHI-PROJECT-19K21238
  • [Presentation] 新規可視化法により見えてきた「活性酸素種産生小胞」によるチロシンホスファターゼの時空間的制御2019

    • Author(s)
      堤 良平
    • Organizer
      第92回日本生化学会大会 シンポジウム「新たなシグナル検出法・アプローチに基づくリン酸化シグナル研究の新展開」
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K21238
  • [Presentation] Visualization of specific protein oxidation evoked by signaling ROS2019

    • Author(s)
      Ryouhei Tsutsumi
    • Organizer
      The Gordon Research Conference on Oxygen Radicals 2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K21238
  • [Presentation] 増殖因子依存的な活性酸素種産生性細胞内小胞の生成と情報伝達2019

    • Author(s)
      堤 良平
    • Organizer
      レドックス・ライフイノベーション第170委員会20周年記念若手シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K21238
  • [Presentation] タンパク質可逆的酸化の特異的可視化による 増殖因子依存的「レドキソソーム」情報伝達の発見2018

    • Author(s)
      堤 良平
    • Organizer
      第91回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-19K21238
  • [Presentation] Mechanism underlying cytoplasmic-nuclear shuttling of SHP22012

    • Author(s)
      Ryouhei Tsutsumi
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌文芸館、札幌市
    • Year and Date
      2012-09-19
    • Data Source
      KAKENHI-PLANNED-22114002
  • [Presentation] がんタンパク質SHP2の細胞質・細胞核間輸送2011

    • Author(s)
      堤良平, 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2011-10-04
    • Data Source
      KAKENHI-PROJECT-22700877
  • [Presentation] がんタンパク質SHP2の細胞質・細胞核間輸送2011

    • Author(s)
      堤良平、高橋昌史、菊地逸平、畠山昌則
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      愛知県
    • Year and Date
      2011-10-04
    • Data Source
      KAKENHI-PROJECT-22700877
  • [Presentation] Regulation of intracellular distribution of SHP2 phosphatase2011

    • Author(s)
      堤良平
    • Organizer
      発がんスパイラル第1回国際シンポジウム&第9回プロテインホスファターゼ国際カンファレンス
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2011-02-01
    • Data Source
      KAKENHI-PROJECT-22700877
  • [Presentation] Cytoplasmic-nuclear shuttling of SHP2 oncoprotein2011

    • Author(s)
      Tsutsumi R
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-05
    • Data Source
      KAKENHI-PLANNED-22114002
  • [Presentation] Regulation of intracellular distribution of SHP2 phosphatase2011

    • Author(s)
      Tsutsumi R, Takahashi A, Kikuchi I, Hatakeyama M
    • Organizer
      1st International Symposium on Carcinogenic Spiral & 9th International Conference on Protein Phosphatase
    • Place of Presentation
      東京都
    • Year and Date
      2011-02-01
    • Data Source
      KAKENHI-PROJECT-22700877
  • 1.  Saito Yoshiro (70357060)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  HATAKEYAMA Masanori (40189551)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  KAMIYA Naoko (40279352)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  MUTOH Hiroyuki (50322392)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  SAITO Yasuhiro (30613004)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  TAKAHASHI Atsushi (00624496)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  有澤 琴子 (00813122)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  金子 尚志 (20907993)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  外山 喬士 (50720918)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  三田 雄一郎 (70609122)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  藤井 重元
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  井田 智章
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  堺 隆一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  小布施 力史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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