MUTOH Hiroyuki 武藤弘行

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MUTO Hiroyuki 武藤弘行

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Researcher Number	50322392
Other IDs
Affiliation (Current)	2023: 自治医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2014 – 2019: 自治医科大学, 医学部, 教授 2009 – 2014: Jichi Medical University, 医学部, 准教授 2005 – 2007: JICHI MEDICAL SCHOOL, School of Medicine, Senior Lecturer, 医学部, 講師 2000 – 2003: Jichi Med.Sch., Faculty Medicine, Senior Lecturer, 医学部, 講師
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology Except Principal Investigator Gastroenterology / Gastroenterology / Biological Sciences
Keywords	Principal Investigator Cdx2 / 腸上皮化生 / Math1 / トランスジェニックマウス / intestinal metaplasia / PCFS / luciferase assay / EMSA / RT-PCR / Western blot … More / 食道 / 胃 / 十二指腸 / Shh / メチル化 / in situ hybridization / microRNA / セクレチン / 消化管ホルモン / 分化 / 増殖 / 転写因子 / 細胞周期 / サイクリン / サイクリン依存性キナーゼ / secretin / gastrointestinal hormone / differentiation / growth / transcription factor / cell cycle / cyclin / cyclin dependent kinase / 吸収上皮細胞 / 腸管内分泌細胞 / 間質 / Intestinal metaplasia / Transgenic mouse / Absorptive enterocytes / Enteroendocrine cells / Stroma / Western-blot / transgenic mouse / Sox9 / 胃癌 … More Except Principal Investigator 腸上皮化生 / トランスジェニックマウス / CDX2 / 転写因子 / Cdx2 / CDX1 / 胃癌 / Sonic Hedgehog / 分化型胃癌 / Lgr5 / transgenic mice / CDX / intestinal metaplasia / transcription factor / Math 1 / Intestinal Metaplasia / Gastric Cancer / siRNA / miRNA / 文化型胃癌 / モデル動物 / 食道 / 胃 / 十二指腸 / Cdx1 / がん / 感染症 / 胃がん / ヘリコバクター・ピロリ / 炎症 / 癌 / 細菌 / シグナル伝達 / 幹細胞 / DCAMKL1 / Bmi1 / 幹細胞マーカー / ヒスタミンH2受容体 / 壁細胞 / 受容体キナーゼ / ヒスタミンH_2受容体 / Histamine H2 receptor / knockout mice / CDX 1,2 / SHH / Transgenic mouse / Transcriptional Factor / Cdx1, 2 / gastric carcinoma / transgenic mouse / COX2 / Math1 / Sonic Hedeehor Less

The role of Sox9 in the gastric carcinomaPrincipal Investigator
- Principal Investigator
  
  Mutoh Hiroyuki
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Jichi Medical University
Analysis of Lgr5-positive cells in the intestinal metaplasia
- Principal Investigator
  
  Hirosawa Takuya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Jichi Medical University
The expresssion of microRNA in the intestinal metaplasia and gastric carcinomaPrincipal Investigator
- Principal Investigator
  
  Mutoh Hiroyuki
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Jichi Medical University
The expression of stem cell marker in intestinal metaplastic mucosa
- Principal Investigator
  
  KENSUKE Yokoyama
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Jichi Medical University
Host response as an enhancer of infection-associated cancer and its regulation
- Principal Investigator
  
  HATAKEYAMA Masanori
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
To clarify the mechanism of the decrease of Shh in intestinal metaplastic mucosaPrincipal Investigator
- Principal Investigator
  
  MUTOH Hiroyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Jichi Medical University
The relationship between Cdx2 and Cdx1 in intestinal metaplastic mucosa
- Principal Investigator
  
  SAKAMOTO Hirotsugu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Jichi Medical University
Studies on the molecular mechanisms leading to development of intestinal metaplasia
- Principal Investigator
  
  SUGANO Kentaro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Jichi Medical University
The intestine-specific homeobox gene Cdx2 induces expression of the bacir helix-loop- helix transcription factor Math1Principal Investigator
- Principal Investigator
  
  MUTOH Hiroyuki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Jichi Medical University
Study on the mechanism of development of differentiated adenocarcinoma from intestinal metaplasia
- Principal Investigator
  
  SUGANO Kentaro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  JICHI MEDICAL SCHOOL
To clarify the mechanism of the development of gastric well differentiated carcinoma from intestinal metaplasia
- Principal Investigator
  
  SATOH Kiichi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  JICHI MEDICAL SCHOOL
胃粘膜腸上皮化生から胃分化型腺癌への進展の分子生物学的メカニズムの解明
- Principal Investigator
  
  SUGANO Kentaro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Jichi Medical University
Transcriptional regulation of transcription factor Cdx2 in intestinal mucosaPrincipal Investigator
- Principal Investigator
  
  MUTOH Hiroyuki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Jichi Medical School
Generation of intestinal metaplasia by ectopic expression of Cdx1 and Cdx2
- Principal Investigator
  
  SUGANO Kentaro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Jichi Medical School
Cell cycle and differentiation of secretin-secreting enteroendocrine cells by transcription factor BETA2.Principal Investigator
- Principal Investigator
  
  MUTOH Hiroyuki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Jichi Medical School
The pathophysiological analysis for histamine H2 receptor knockout mice.
- Principal Investigator
  
  SUGANO Kentaro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Gastroenterology
- Research Institution
  Jichi Medical School

All 2015 2014 2013 2012 2011 2010 2009 2007 2006 2005 2004 Other

All Journal Article Presentation Book

[Book] Transcription factor Cdx2, intestinal metaplasia, and gastric carcinoma.In Recent adVances in gastrointestinal carcinogenesis2006
- Author(s)
  Mutoh H
- Total Pages
  62
- Publisher
  Transworld Research Network
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590697
[Journal Article] Comparative analysis of gastrointestinal microbiota between normal and caudal-related homeobox 2 (cdx2) transgenic mice.2015
- Author(s)
  Sakamoto H, Asahara T, Chonan O, Yuki N, Mutoh H, Hayashi S, Yamamoto H, Sugano K.
- Journal Title
  
  Intest Res.
  
  Volume: 13 Pages: 39-34
- DOI
  10.5217/ir.2015.13.1.39
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23590926, KAKENHI-PROJECT-24590926, KAKENHI-PROJECT-26460948
[Journal Article] Cyclooxygenase 2 in gastric carcinoma is expressed in doublecortin and CaM kinase-like-1-positive tuft cells.2014
- Author(s)
  Mutoh H, Sashikawa M, Sakamoto H, Tateno T
- Journal Title
  
  Gut Liver
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590926
[Journal Article] Cyclooxygenase 2 in gastric carcinoma is expressed in doublecortin- and CaM kinase-like-1-positive tuft cells.2014
- Author(s)
  Mutoh H, Sashikawa M, Sakamoto H, Tateno T.
- Journal Title
  
  Gut Liver.
  
  Volume: 8 Pages: 508-518
- DOI
  10.5009/gnl13237
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23590926, KAKENHI-PROJECT-24590926, KAKENHI-PROJECT-26460948
[Journal Article] Cyclooxygenase 2 in gastric carcinoma is expressed in doublecortin and CaM kinase-like-1-positive tuft cells.2014
- Author(s)
  Mutoh H, Sashikawa M, Sakamoto H, Tateno T
- Journal Title
  
  Gut Liver
  
  Volume: in prerss
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590926
[Journal Article] SOX9 Is Highly Expressed in Nonampullary Duodenal Adenoma and Adenocarcinoma in Humans.2013
- Author(s)
  Sakamoto H, Mutoh H, Miura Y, Sashikawa M, Yamamoto H, Sugano K
- Journal Title
  
  Gut and Liver
  
  Volume: 7 Pages: 513-518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590926
[Journal Article] SOX9 Is Highly Expressed in Nonampullary Duodenal Adenoma and Adenocarcinoma in Humans.2013
- Author(s)
  Sakamoto H, Mutoh H, Miura Y, Sashikawa M, Yamamoto H, Sugano K
- Journal Title
  
  Gut Liver
  
  Volume: 7 Pages: 513-518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590926
[Journal Article] CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemness-associated reprogramming factors SALL4 and KLF52012
- Author(s)
  Fujii, Y.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 109 Pages: 20584-20589
- DOI
  10.1073/pnas.1208651109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240085, KAKENHI-PROJECT-22300169, KAKENHI-PROJECT-23590926, KAKENHI-PROJECT-24221011, KAKENHI-PROJECT-24249068, KAKENHI-PROJECT-24590926, KAKENHI-PROJECT-24659103, KAKENHI-ORGANIZER-22114001, KAKENHI-PLANNED-22114002, KAKENHI-PUBLICLY-23118508
[Journal Article] Sox2 expression is maintained while gastric phenotype is completely lost in Cdx2-induced intestinal metaplastic mucosa2011
- Author(s)
  Mutoh H, Sashikawa M, Sugano K.
- Journal Title
  
  Differentiation
  
  Volume: 81 Pages: 92-8
- Data Source
  KAKENHI-PROJECT-21590793
[Journal Article] Sox2 expression is maintained while gastric phenotype is completely lost in Cdx2-Induced intestinal metaplastic mucosa2011
- Author(s)
  Muto H, Sashikawa M, Sugano K
- Journal Title
  
  Differentiation
  
  Volume: 81 Pages: 92-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590793
[Journal Article] Cell lineage dynamics in the process leading to intestinal metaplasia2011
- Author(s)
  Sakamoto H, Mutoh H, Hayakawa H, Sashikawa M, Sugano K.
- Journal Title
  
  J Gastroenterol
  
  Volume: 46 Pages: 620-8
- Data Source
  KAKENHI-PROJECT-21590793
[Journal Article] Cell lineage dynamics in the process leading to intestinal metaplasia2011
- Author(s)
  Sakamoto H, Mutoh H, Hayakawa H, Sashikawa M, Sugano K
- Journal Title
  
  J Gastroenterol
  
  Volume: 46 Pages: 620-8
- NAID
  10029029095
- Data Source
  KAKENHI-PROJECT-21590794
[Journal Article] Cell lineage dynamics in the prosess leading to intestinal metaplasia2011
- Author(s)
  Sakamoto H, Mutoh H, Hayakawa H, Sashikawa M, Sugano K
- Journal Title
  
  J Gastroenterol
  
  Volume: 46 Pages: 620-628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590793
[Journal Article] Cell lineage dynamics in the prosess leading to intestinal metaplasia2011
- Author(s)
  Sakamoto H, Mutoh H, Hayakawa H, Sashikawa M, sugano K
- Journal Title
  
  J Gastroenterol
  
  Volume: 46 Pages: 620-628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590794
[Journal Article] SOX9 is expressed in normal stomach, intestinal metaplasia, and gastric carcinoma in humans2011
- Author(s)
  Sashikawa Kimura M, Mutoh H, Sugano K
- Journal Title
  
  J Gastroenterol
  
  Volume: 46 Pages: 1292-9
- Data Source
  KAKENHI-PROJECT-21590794
[Journal Article] Sox2 expression is maintained while gastric phenotype is completely lost in Cdx2-Induced intestinal metaplastic mucosa2011
- Author(s)
  Muto H, Sashikawa M, Sugano K
- Journal Title
  
  Differentiation
  
  Volume: 81 Pages: 92-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590794
[Journal Article] Sox2 expression is maintained while gastric phenotype is completely lost in Cdx2-induced intestinal metaplastic mucosa2011
- Author(s)
  Mutoh H
- Journal Title
  
  Differentiation
  
  Volume: 81 Pages: 92-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590793
[Journal Article] Sox2 expression is maintained while gastric phenotype is completely lost in Cdx2-induced intestinal metaplastic mucosa2011
- Author(s)
  Mutoh H
- Journal Title
  
  Differentiation
  
  Volume: 81 Pages: 92-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590794
[Journal Article] SOX9 is expressed in normal stomach, intestinal metaplasia, and gastric carcinoma in humans2011
- Author(s)
  Sashikawa Kimura M, Mutoh H, Sugano K.
- Journal Title
  
  J Gastroenterol
  
  Volume: 46 Pages: 1292-1299
- Data Source
  KAKENHI-PROJECT-21590793
[Journal Article] Sox2 expression is maintained while gastric phenotype is completely lost in Cdx2-induced intestinal metaplastic mucosa2011
- Author(s)
  Mutoh H, Sashikawa M, Sugano K
- Journal Title
  
  Differentiation
  
  Volume: 81 Pages: 92-8
- Data Source
  KAKENHI-PROJECT-21590794
[Journal Article] Monocyte chemoattractant protein-1 is generated via TGF-b by myofibroblasts in gastric intestinal metaplasia and carcinoma without H.pylori infection2010
- Author(s)
  Mutoh H
- Journal Title
  
  Cancer Science
  
  Volume: 101 Pages: 1783-1789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590793
[Journal Article] Monocyte chemoattractant protein-1 is generated via TGF-b by myofibroblasts in gastric intestinal metaplasia and carcinoma without H.pylori infection2010
- Author(s)
  Mutoh H
- Journal Title
  
  Cancer Science
  
  Volume: 101 Pages: 1783-1789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590794
[Journal Article] Direct repression of sonic hedgehog expression in the stomach by Cdx2 leads to intestinal transformation2010
- Author(s)
  Mutoh H, Hayakawa H, Sashikawa M, Sakamoto H, Sugano K
- Journal Title
  
  Biochem J (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590793
[Journal Article] Direct repression of Sonic Hedgehog expression in the stomach by Cdx2 leads to intestinal transformation2010
- Author(s)
  Mutoh H, Hayakawa H, Sashikawa M, Sakamoto H, Sugano K.
- Journal Title
  
  Biochem J
  
  Volume: 427 Pages: 423-34
- Data Source
  KAKENHI-PROJECT-21590793
[Journal Article] Expression of Claudin-2 in intestinal metaplastic mucosa of Cdx2-transgenic mouse stomach2010
- Author(s)
  Sakamoto H, Mutoh H, Sugano K
- Journal Title
  
  Scand J Gastroenterol
  
  Volume: 45 Pages: 1273-80
- Data Source
  KAKENHI-PROJECT-21590794
[Journal Article] Direct repression of sonic hedgehog expression in the stomach by Cdx2 leads to intestinal transformation.2010
- Author(s)
  Mutoh H
- Journal Title
  
  Biochem J
  
  Volume: 427 Pages: 423-434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590794
[Journal Article] Direct repression of Sonic Hedgehog expression in the stomach by Cdx2 leads to intestinal transformation2010
- Author(s)
  Mutoh H, Hayakawa H, Sashikawa M, Sakamoto H, Sugano K
- Journal Title
  
  Biochem J
  
  Volume: 427 Pages: 423-34
- Data Source
  KAKENHI-PROJECT-21590794
[Journal Article] Direct repression of sonic hedgehog expression in the stomach by Cdx2 leads to intestinal transformation2010
- Author(s)
  Mutoh H, Hayakawa H, Sashikawa M, Sakamoto H, Sugano K
- Journal Title
  
  Biochem J 427
  
  Pages: 423-434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590794
[Journal Article] Expression of Claudin-2 in intestinal metaplastic mucosa of Cdx2-transgenic mouse stomach2010
- Author(s)
  Sakamoto H, Mutoh H, Sugano K.
- Journal Title
  
  Scand J Gastroenterol
  
  Volume: 45 Pages: 1273-80
- Data Source
  KAKENHI-PROJECT-21590793
[Journal Article] Monocyte chemoattractant protein-1 is generated via TGF-beta by myofibroblasts in gastric intestinal metaplasia and carcinoma without H. pylori infection2010
- Author(s)
  Mutoh H, Sashikawa M, Hayakawa H, Sugano K.
- Journal Title
  
  Cancer Sci
  
  Volume: 101 Pages: 1783-9
- Data Source
  KAKENHI-PROJECT-21590793
[Journal Article] Direct repression of sonic hedgehog expression in the stomach by Cdx2 leads to intestinal transformation.2010
- Author(s)
  Mutoh H
- Journal Title
  
  Biochem J
  
  Volume: 427 Pages: 423-434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590793
[Journal Article] Monocyte chemoattractant protein-1 is generated via TGF-beta by myofibroblasts in gastric intestinal metaplasia and carcinoma without H. pylori infection2010
- Author(s)
  Mutoh H, Sashikawa M, Hayakawa H, Sugano K
- Journal Title
  
  Cancer Sci
  
  Volume: 101 Pages: 1783-9
- Data Source
  KAKENHI-PROJECT-21590794
[Journal Article] Intestinal metaplasia in gallbladder correlates with high amylase levels in bile in patients with a morphologically normal pancreaticobiliary duct2009
- Author(s)
  Sakamoto H, Mutoh H, Ido K, Satoh S, Kumagai M, Hayakawa H, Tamada K, Sugano K
- Journal Title
  
  Hum Pathol
  
  Volume: 40 Pages: 1762-7
- Data Source
  KAKENHI-PROJECT-21590793
[Journal Article] Intestinal metaplasia in gallbladder correlates with high amylase levels in bile in patients with a morphologically normal pancreaticobiliary duct2009
- Author(s)
  Sakamoto H, Mutoh H, Ido K, Satoh S, Kumagai M, Hayakawa H, Tamada K, Sugano K
- Journal Title
  
  Hum Pathol
  
  Volume: 40 Pages: 1762-7
- Data Source
  KAKENHI-PROJECT-21590794
[Journal Article] Transgenic Cdx2 induces endogenous Cdx1 in intestinal metaplasia of Cdx2-transgenic mouse stomach2009
- Author(s)
  Mutoh H, Hayakawa H, Sakamoto H, Sashikawa M, Sugano K
- Journal Title
  
  FEBS J
  
  Volume: 276 Pages: 5821-31
- Data Source
  KAKENHI-PROJECT-21590794
[Journal Article] Transgenic Cdx2 induces endogenous Cdx1 in intestinal metaplasia of Cdx2-transgenic mouse stomach2009
- Author(s)
  Mutoh H, Hayakawa H, Sakamoto H, Sashikawa M, Sugano K.
- Journal Title
  
  FEBS J 276
  
  Pages: 5821-5831
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590794
[Journal Article] Transgenic Cdx2 induces endogenous Cdx1 in intestinal metaplasia of Cdx2-transgenic mouse stomach2009
- Author(s)
  Mutoh H, Hayakawa H, Sakamoto H, Sashikawa M, Sugano K
- Journal Title
  
  FEBS J
  
  Volume: 276 Pages: 5821-31
- Data Source
  KAKENHI-PROJECT-21590793
[Journal Article] Homeobox protein CDX2 reduces Cox-2 transcription by inactivating the DNA-binding capacity of nuclear factor-Κb.2007
- Author(s)
  Hiroyuki Mutoh
- Journal Title
  
  Journal of Gastroenteol 42
  
  Pages: 719-729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390224
[Journal Article] Homeobox protein CDX2 reduces Cox-2 transcription by inactivating the DNA-binding capacity of nuclear factor-kB2007
- Author(s)
  Mutoh, H
- Journal Title
  
  J Gastroenterol 42
  
  Pages: 719-729
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390224
[Journal Article] Homeobox protein CDX2 reduces Cox-2 transcription by inactivating the DNA-binding capacity of nuclear factor-kappaB2007
- Author(s)
  Mutoh H
- Journal Title
  
  J Gastroenterol 42
  
  Pages: 719-729
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390224
[Journal Article] Homeobox protein CDX2 reduces Cox-2 transcription by inactivating the DNA-binding capacity of nuclear factor-kB2007
- Author(s)
  Mutoh, H
- Journal Title
  
  J Gastroenterol 42
  
  Pages: 719-729
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590697
[Journal Article] Homeobox protein CDX2 reduces Cox-2 transcription by inactivating the DNA-binding capacity of nuclear factor-kappaB2007
- Author(s)
  Mutoh H
- Journal Title
  
  J Gastroenterol 42
  
  Pages: 719-729
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590697
[Journal Article] Homeobox protein CDX2 reduces Cox-2 transcription by inactivating the DNA-binding capatity of nuclear factor-kappaB2007
- Author(s)
  Mutoh H
- Journal Title
  
  J Gastroenterol 42
  
  Pages: 719-729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590697
[Journal Article] A close relationaship between intestinal metaplasia and Cdx2 expression in human gallbladders with cholelithiasis.2007
- Author(s)
  Sakamoto H, Mutoh H, Ido K, Satoh K, Hayakawa H, Sugano K
- Journal Title
  
  Hum Pathol 38
  
  Pages: 66-71
- Data Source
  KAKENHI-PROJECT-18590697
[Journal Article] Helicobacter pylori eradication induces marked increase in H^+/K^+-adenosine triphosphatase expression without altering parietal cell number in human gastric mucasa.2006
- Author(s)
  H.Osawa, H.Ohnishi, H.Mutoh, K.Sugano, et al.
- Journal Title
  
  Gut 55
  
  Pages: 152-157
- Data Source
  KAKENHI-PROJECT-18390224
[Journal Article] The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math12006
- Author(s)
  Mutoh H
- Journal Title
  
  Differentiation 74
  
  Pages: 313-321
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590697
[Journal Article] The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math12006
- Author(s)
  Hiroyuki Mutoh, Hirotsugu Sakamoto, Hiroko Hayakawa, Yukitomo Arao, Kiichi Satoh, Mitsuhiro Nokubi, Kentaro Sugano
- Journal Title
  
  Differentiation (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590622
[Journal Article] The intestine-specific homeobx gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math 1.2006
- Author(s)
  Mutoh H, Sakamoto H, Hayakawa H, Arao Y, Satoh K, Nokubi M, Sugano K
- Journal Title
  
  Differentiation 74
  
  Pages: 313-321
- Data Source
  KAKENHI-PROJECT-18590697
[Journal Article] The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math12006
- Author(s)
  Mutoh, H
- Journal Title
  
  Differentiation 74
  
  Pages: 313-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590697
[Journal Article] Helicobacter pylori eradication induces marked increase in H+/K+- Adenosine triphosphatase expression without altering parietal cell number in human gastric mucosa.2006
- Author(s)
  Osawa H., Mutoh H., Satoh K., Sugano K.et al.
- Journal Title
  
  Gut 55(2)
  
  Pages: 152-157
- Data Source
  KAKENHI-PROJECT-16390214
[Journal Article] Differential gene expression between flat adenoma and normal mucasa in the colon using microarray.2006
- Author(s)
  Kita H, Hikichi Y, Hikami K, Tsuneyama K, Cui Z-G, Osawa H, Ohnishi H, Mutoh H, Hoshino H, Bowlus CL, Yamamoto H, Sugano K
- Journal Title
  
  J Gastroenterol 41
  
  Pages: 1053-1063
- Data Source
  KAKENHI-PROJECT-18590697
[Journal Article] The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Mathl2006
- Author(s)
  Hiroyuki Mutoh, Hirotsugu Sakamoto, Hiroko Hayakawa, Yukitomo Aroa, Kiichi Satoh, Mitsuhiro Nokubi, Kentaro Sugano
- Journal Title
  
  Differentiation (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390214
[Journal Article] Helicobacter pylori eradication induces marked increase in H^+/K^+-adenosine triphosphatase expression without altcring parictal cell number in human gastric2006
- Author(s)
  Osawa H, Kita H, Ohnishi H, Hoshino H, Mutoh H, Ishino Y, Watanabe E, Satoh K, Sugano K
- Journal Title
  
  Gut 55
  
  Pages: 152-157
- Data Source
  KAKENHI-PROJECT-18590697
[Journal Article] The intestine-specific homeobox gene Csx2 induces expression of the basic helix-loop-helix transcription facter Math 1.2006
- Author(s)
  Hiroyuki Mutoh, Hirotsugu Sakamoto, Hiroko Hayakawa, Yukitomo Arao, Kiichi Satoh, Mitsuhiro Nokubi, Kentaro Sugano
- Journal Title
  
  Differentiation (in press)
- Data Source
  KAKENHI-PROJECT-16590622
[Journal Article] The Intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math I.2006
- Author(s)
  H.Mutoh, H.Sakamoto, K.Sugano, et al.
- Journal Title
  
  differentiation 74
  
  Pages: 313-321
- Data Source
  KAKENHI-PROJECT-18390224
[Journal Article] Pericryptal fibroblast sheath in intestinal metaplasia and gastric carcinoma.2005
- Author(s)
  Mutoh H, Sakurai S, Satoh K, Osawa H, Tomiyama T, Kita H, Yoshida T, Tamada K, Yamamoto H, Isoda N, Ido K, Sugano K.
- Journal Title
  
  Gut. 54
  
  Pages: 33-39
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590622
[Journal Article] Pericryptal fibroblast sheath in intestinal metaplasia and gastric carcinoma.2005
- Author(s)
  H.Mutoh, S.Sakurai, K.Satoh, H.Osawa, T.Tomiyama, H.Kita, K.Sugano et al.
- Journal Title
  
  Gut 54
  
  Pages: 33-39
- Data Source
  KAKENHI-PROJECT-16590622
[Journal Article] Pericryptal fibroblast sheath in intestinal metaplasia and gastric carcinoma.2005
- Author(s)
  H.Mutoh, S.Sakurai, K.Satoh, H.Osawa, T.Tomiyama, H.Kita, K.Sugano et al.
- Journal Title
  
  Gut 54
  
  Pages: 33-39
- Data Source
  KAKENHI-PROJECT-16390214
[Journal Article] Cdx2 specifies the differentiation of morphological as well as functional absorptive enterocytes of the small intestine.2005
- Author(s)
  Mutoh H., Satoh K., Sugano K.et al.
- Journal Title
  
  Int.J.Dev.Biol. 49(7)
  
  Pages: 867-871
- Data Source
  KAKENHI-PROJECT-16390214
[Journal Article] Pericryptal fibroblast sheath in intestinal metaplasia and gastric carcinoma2005
- Author(s)
  Mutoh H, Sakurai S, Satoh K, Osawa H, Tomiyama T, Kita H, Yoshida T, Tamada K, Yamamoto H, Isoda N, Ido K, Sugano K.
- Journal Title
  
  Gut 54
  
  Pages: 33-39
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590622
[Journal Article] Cdx2 specifies the differentiation of morphological as well as functional absorptive enterocytes of the small intestine2005
- Author(s)
  Mutoh H, Satoh K, Kita H, Sakamoto H, Hayakawa H, Yamamoto H, Isoda N, Tamada K, Ido K, Sugano K
- Journal Title
  
  Int J Dev Biol 49
  
  Pages: 867-871
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590622
[Journal Article] Pericryptal fibroblast sheath in intestinal metaplasia and gastric carcinoma.2005
- Author(s)
  Mutoh H, Sakurai S, Satoh K, Osawa H, Tomiyama T, Kita H, Yoshida T, Tamada K, Yamamoto H, Isoda N, Ido K, Sugano K.
- Journal Title
  
  Gut. 54
  
  Pages: 33-39
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390214
[Journal Article] Pericryptal fibroblast sheath in intestinal metaplasia and gastric carcinoma.2005
- Author(s)
  Mutoh H, Sakurai S, Satoh K, Osawa H, Tomiyama T, Kita H, Yoshida T, Tamada K, Yamamoto H, Isoda N, Ido K, Sugano K.
- Journal Title
  
  Gut 54
  
  Pages: 33-39
- Data Source
  KAKENHI-PROJECT-16590622
[Journal Article] Cdx2 specifies the differentiation of morphological as well as functional absorptive enterocytes of the small intestine.2005
- Author(s)
  Mutoh H, Satoh K, Kita H, Sakamoto H, Hayakawa H, Yamamoto H, Isoda N, Tamada K, Ido K, Sugano K
- Journal Title
  
  Int J Dev Biol. 49
  
  Pages: 867-871
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390214
[Journal Article] Pericryptal fibroblast sheath in intestinal metaplasia and gastric carcinoma.2005
- Author(s)
  Mutoh H, Satoh K, Osawa H, Sugano K.et al.
- Journal Title
  
  Gut 54(1)
  
  Pages: 33-39
- Data Source
  KAKENHI-PROJECT-16390214
[Journal Article] Cdx2 specifies the differentiation of morphological as well as functional absorptive enterocytes of the small intestine2005
- Author(s)
  Mutoh H, Satoh K, Kita H, Sakamoto H, Hayakawa H, Yamamoto H, Isoda N, Tamada K, Ido K, Sugano K
- Journal Title
  
  Int J Dev Biol 49
  
  Pages: 867-871
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390214
[Journal Article] Cdx2 specifies the differentiation of morphological as well as functional absorptive enterocytes of the small intestine.2005
- Author(s)
  Mutoh H, Satoh K, Kita H, Sakamoto H, Hayakawa H, Yamamoto H, Isoda N, Tamada K, Ido K, Sugano K
- Journal Title
  
  Int J Dev Biol. 49
  
  Pages: 867-871
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590622
[Journal Article] Pericryptal fibroblast sheath in intestinal metaplasia and gastric carcinoma2005
- Author(s)
  Mutoh H, Sakurai S, Satoh K, Osawa H, Tomiyama T, Kita H, Yoshida T, Tamada K, Yamamoto H, Isoda N, Ido K, Sugano K
- Journal Title
  
  Gut 54
  
  Pages: 33-39
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390214
[Journal Article] Histamine-2 receptor expression in gastric mucosa before and after Helicobacter pylori cure.2005
- Author(s)
  H.Osawa, H.Mutoh, K.Satoh, K.Sugano, et al.
- Journal Title
  
  Aliment.Pharmacol.Ther. 21(Suppl.2)
  
  Pages: 92-98
- Data Source
  KAKENHI-PROJECT-16390214
[Journal Article] Cdx1 induced intestinal metaplasia in the transgenic mouse stomach : comparative study with Cdx2 transgenic mice2004
- Author(s)
  Mutoh H, Sakurai S, Satoh K, Osawa H, Hakamata Y, Takeuchi T, Sugano K
- Journal Title
  
  Gut 53
  
  Pages: 1416-1423
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390214
[Journal Article] Aberrant expression of CDX2 in the metaplastic epithelium and inflammatory mucosa of gallbladder.2004
- Author(s)
  H.Osawa, H.Kita, K.Satoh, H.Ohnishi, Y.Kaneko, H.Mutoh, K.Sugano et al.
- Journal Title
  
  Am.J.Surg.Pathol. 28・9
  
  Pages: 1253-1254
- Data Source
  KAKENHI-PROJECT-16390214
[Journal Article] Cdx1 induced intestinal metaplasia in the transgenic mouse stomach : comparative study with Cdx2 transgenic mice.2004
- Author(s)
  Mutoh H, Sakurai S, Satoh K, Osawa H, Hakamata Y, Takeuchi T, Sugano K.
- Journal Title
  
  Gut. 53
  
  Pages: 1416-1423
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590622
[Journal Article] Development of gastric carcinoma from intestinal metaplasia in Cdx2-transgenic mice2004
- Author(s)
  Mutoh H, Sakurai S, Satoh K, Tamada K, Kita H, Osawa H, Tomiyama T, Sato Y, Yamamoto H, Isoda N, Yoshida T, Ido K, Sugano K
- Journal Title
  
  Cancer Res. 64
  
  Pages: 7740-7747
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390214
[Journal Article] Cdx1 induced intestinal metaplasia in the transgenic mouse stomach : Comparative study with Cdx2 transgenic mice.2004
- Author(s)
  H.Mutoh, S.Sakurai, K.Satoh, H.Osawa, Y.Hakamata, T.Takeuchi, K.Sugano
- Journal Title
  
  Gut 53・10
  
  Pages: 1416-1423
- Data Source
  KAKENHI-PROJECT-16590622
[Journal Article] Cdx1 induced intestinal metaplasia in the transgenic mouse stomach : comparative study with Cdx2 transgenic mice.2004
- Author(s)
  Mutoh H, Sakurai S, Satoh K, Osawa H, Hakamata Y, Takeuchi T, Sugano K.
- Journal Title
  
  Gut. 53
  
  Pages: 1416-1423
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390214
[Journal Article] Development of gastric carcinoma from intestinal metaplasia in Cdx2-transgenic mice.2004
- Author(s)
  H.Mutoh, S.Sakurai, K.Sato, K.Tamada, H.Kita, H.Osawa, K.Sugano, et al.
- Journal Title
  
  Cancer Research 64
  
  Pages: 7740-7747
- Data Source
  KAKENHI-PROJECT-16390214
[Journal Article] Development of gastric carcinoma from intestinal metaplasia in Cdx2-transgenic mice.2004
- Author(s)
  Mutoh H, Sakurai S, Satoh K, Tamada K, Kita H, Osawa H, Tomiyama T, Sato Y, Yamamoto H, Isoda N, Yoshida T, Ido K, Sugano K.
- Journal Title
  
  Cancer Res. 64
  
  Pages: 7740-7747
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590622
[Journal Article] Development of gastric carcinoma from intestinal metaplasia in Cdx2-transgenic mice.2004
- Author(s)
  H.Mutoh, S.Sakurai, K.Sato, K.Tamada, H.Kita, H.Osawa, K.Sugano et al.
- Journal Title
  
  Cancer Research 64
  
  Pages: 7740-7747
- Data Source
  KAKENHI-PROJECT-16590622
[Journal Article] Development of gastric carcinoma from intestinal metaplasia in Cdx2-transgenic mice2004
- Author(s)
  Mutoh H, Sakurai S, Satoh K, Tamada K, Kita H, Osawa H, Tomiyama T, Sato Y, Yamamoto H, Isoda N, Yoshida T, Ido K, Sugano K.
- Journal Title
  
  Cancer Res. 64
  
  Pages: 7740-7747
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590622
[Journal Article] Cdx1 induced intestinal metaplasia in the transgenic mouse stomach : Comparative study with Cdx2 transgenic mice.2004
- Author(s)
  H.Mutoh, S.Sakurai, K.Satoh, H.Osawa, Y.Hakamata, T.Takeuchi, K.Sugano
- Journal Title
  
  Gut 53・10
  
  Pages: 1416-1423
- Data Source
  KAKENHI-PROJECT-16390214
[Journal Article] Development of gastric carcinoma from intestinal metaplasia in Cdx2-transgenic mice.2004
- Author(s)
  Mutoh H, Sakurai S, Satoh K, Tamada K, Kita H, Osawa H, Tomiyama T, Sato Y, Yamamoto H, Isoda N, Yoshida T, Ido K, Sugano K.
- Journal Title
  
  Cancer Res. 64
  
  Pages: 7740-7747
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390214
[Journal Article] Aberrant expression of CDX2 in the metaplastic epithelium and inflammatory mucosa of gallbladder.2004
- Author(s)
  H.Osawa, H.Kita, K.Satoh, H.Ohnishi, Y.Kaneko, H.Mutoh, K.Sugano et al.
- Journal Title
  
  Am.J.Surg.Pathol. 28・9
  
  Pages: 1253-1254
- Data Source
  KAKENHI-PROJECT-16590622
[Journal Article] Cdx1 induced intestinal metaplasia in the transgenic mouse stomach : comparative study with Cdx2 transgenic mice2004
- Author(s)
  Mutoh H, Sakurai S, Satoh K, Osawa H, Hakamata Y, Takeuchi T, Sugano K.
- Journal Title
  
  Gut 53
  
  Pages: 1416-1423
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590622
[Journal Article] The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math 1
- Author(s)
  Hiroyuki Mutoh, Hirotsugu Sakamoto, Hiroko Hayakawa, Yukitomo Arao, Kiichi Satoh, Mitsuhiro Nokubi, Kentaro Sugano
- Journal Title
  
  Differentiation (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590622
[Journal Article] The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1
- Author(s)
  Hiroyuki Mutoh, Hirotsugu Sakamoto, Hiroko Hayakawa, Yukitomo Arao, Kiichi Satoh, Mitsuhiro Nokubi, Kentaro Sugano
- Journal Title
  
  Differentiation (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390214
[Presentation] The development of differentiated gastric adenocarcinoma from intestinal metaplasia2007
- Author(s)
  Mutoh, H
- Organizer
  7th conference of risk factor of gastric carcinoma
- Place of Presentation
  Tokyo
- Year and Date
  2007-06-16
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590697

1. SATOH Kiichi (50275707)

# of Collaborated Projects: 8 results

# of Collaborated Products: 34 results
2. SUGANO Kentaro (60179116)

# of Collaborated Projects: 8 results

# of Collaborated Products: 36 results
3. OSAWA Hiroyuki (70260833)

# of Collaborated Projects: 4 results

# of Collaborated Products: 25 results
4. SAKAMOTO Hirotsugu (50536175)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
5. KUMAKURA Yasuhisa (50275682)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. HATAKEYAMA Masanori (40189551)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KAMIYA Naoko (40279352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TSUTSUMI Ryohei (50435872)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SAITO Yasuhiro (30613004)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TAKAHASHI Atsushi (00624496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KENSUKE Yokoyama (40598926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Hirosawa Takuya (50570660)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. ISHINO Yumiko (80275685)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. OONISHI Hirohide (00313023)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. YOSHIZAWA Mitsuyo (80406074)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 深澤啓子 (60311940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 木平健 (70195345)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 福嶋康之

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 川上訓

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 岩本美智子

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. SUZUKI Hidekazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MUTOH Hiroyuki 武藤 弘行

MUTO Hiroyuki 武藤 弘行

Research Projects

Research Products

Co-Researchers

The role of Sox9 in the gastric carcinomaPrincipal Investigator

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The expresssion of microRNA in the intestinal metaplasia and gastric carcinomaPrincipal Investigator

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To clarify the mechanism of the decrease of Shh in intestinal metaplastic mucosaPrincipal Investigator

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The intestine-specific homeobox gene Cdx2 induces expression of the bacir helix-loop- helix transcription factor Math1Principal Investigator

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Transcriptional regulation of transcription factor Cdx2 in intestinal mucosaPrincipal Investigator

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MUTOH Hiroyuki 武藤弘行

MUTO Hiroyuki 武藤弘行