Yusa Kosuke 遊佐宏介

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YUSA Kosuke 遊佐宏介

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Researcher Number	00813180
Affiliation (Current)	2025: 京都大学, 医生物学研究所, 教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 京都大学, 医生物学研究所, 教授 2020: 京都大学, ウイルス・再生医科学研究所, 教授
Review Section/Research Field	Principal Investigator Medium-sized Section 50:Oncology and related fields / Medium-sized Section 90:Biomedical engineering and related fields / Biological Sciences Except Principal Investigator Basic Section 27040:Biofunction and bioprocess engineering-related / Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator CRISPR / 合成致死 / 造血器腫瘍 / SWI/SNF / Cre / 分子標的 / 増殖必須因子 / 多発性骨髄腫 / in vivo CRISPRスクリーニング / in vivo model … More / Leukemia / Genetic screening / MM / T-ALL / スクリーニング / Flp / ゲノム編集 / in vivoモデル / 白血病 / 遺伝学的スクリーニング / CRISPR-Cas9 / 内胚葉 / 分化指向性 / 細胞分化 / 未分化能 / 多能性 / CRISPRスクリーニング / 胚性内胚葉 / 分化 / ヒトiPS細胞 / ヒトES細胞 … More Except Principal Investigator 細胞内バイオ医薬 / キメラタンパク質 / CRISPR screen / awakening regulator / 休眠がん細胞 / fibrocyte / 骨髄線維症 Less

SWI/SNF合成致死遺伝子による造血器腫瘍新規治療戦略の確立Principal Investigator
- Principal Investigator
  
  遊佐宏介
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Kyoto University
Generation and functional analysis of an awakening regulator for awakening quiescent cancer cells
- Principal Investigator
  
  門之園哲哉
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 27040:Biofunction and bioprocess engineering-related
- Research Institution
  Institute of Science Tokyo
腫瘍性fibrocyteの本態解明と、骨髄線維症診断・治療への展開
- Principal Investigator
  
  下田和哉
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  University of Miyazaki
in vivo CRISPRスクリーニングの技術確立と生体内細胞増殖機構の解析Principal Investigator
- Principal Investigator
  
  遊佐宏介
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Kyoto University
Analysis of human iPSC differentiation into definitive endoderm using CRISPR screeningPrincipal Investigator
- Principal Investigator
  
  YUSA Kosuke
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Fund for the Promotion of Joint International Research (Home-Returning Researcher Development Research)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University

All 2024 2023 2022 2021 2019 2018

All Journal Article Presentation

[Journal Article] Canonical BAF complex regulates the oncogenic program in human T-cell acute lymphoblastic leukemia2024
- Author(s)
  Aoki Kazunari、Hyuga Mizuki、Tarumoto Yusuke、Nishibuchi Gohei、Ueda Atsushi、Ochi Yotaro、Sugino Seiichi、Mikami Takashi、Kobushi Hirokazu、Kato Itaru、Akahane Koshi、Inukai Takeshi、Takaori-Kondo Akifumi、Takita Junko、Ogawa Seishi、Yusa Kosuke
- Journal Title
  
  Blood
  
  Volume: 143 Issue: 7 Pages: 604-618
- DOI
  10.1182/blood.2023020857
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18264, KAKENHI-PROJECT-21K08393, KAKENHI-PROJECT-22K16320, KAKENHI-PROJECT-21H04959, KAKENHI-PROJECT-23K24298
[Journal Article] AKT-mTORC1 reactivation is the dominant resistance driver for PI3Kβ/AKT inhibitors in PTEN-null breast cancer and can be overcome by combining with Mcl-1 inhibitors2022
- Author(s)
  Dunn S, Eberlein C, Yu J, Gris-Oliver A, Ong SH, Yelland U, Cureton N, Staniszewska A, McEwen R, Fox M, Pilling J, Hopcroft P, Coker EA, Jaaks P, Garnett MJ, Isherwood B, Serra V, Davies BR, Barry ST, Lynch JT, Yusa K
- Journal Title
  
  Oncogene
  
  Volume: 41 Issue: 46 Pages: 5046-5060
- DOI
  10.1038/s41388-022-02482-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04959
[Journal Article] KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements2021
- Author(s)
  Au YZ, Gu M, De Braekeleer E, Gozdecka M, Aspris D, Tarumoto Y, Cooper J, Yu J, Ong SH, Chen X, Tzelepis K, Huntly BJP, Vassiliou G, Yusa K.
- Journal Title
  
  Leukemia
  
  Volume: 35 Issue: 4 Pages: 1012-1022
- DOI
  10.1038/s41375-020-1001-z
- NAID
  120006976051
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20146, KAKENHI-PROJECT-21H04959
[Journal Article] Minimal genome-wide human CRISPR-Cas9 library.2021
- Author(s)
  Goncalves E, Thomas M, Behan FM, Picco G, Pacini C, Allen F, Vinceti A, Sharma M, Jackson DA, Price S, Beaver CM, Dovey O, Parry-Smith D, Iorio F, Parts L, Yusa K, Garnett MJ.
- Journal Title
  
  Genome Biology
  
  Volume: 22 Issue: 1
- DOI
  10.1186/s13059-021-02268-4
- Description
  印刷中
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20146
[Presentation] Development and Applications of CRISPR-KO screening2023
- Author(s)
  遊佐宏介
- Organizer
  日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H04959
[Presentation] Development and Applications of CRISPR-KO screening2023
- Author(s)
  遊佐宏介
- Organizer
  日本がん学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-21H04959
[Presentation] Canonical BAF complex is essential for the RUNX1-driven oncogenic transcriptional program in human T-cell acute lymphoblastic leukemia2023
- Author(s)
  Aoki K, Hyuga M, Tarumoto Y, Nishibuchi G, Ochi Y, Sugino S, Mikami T, Kobushi H, Kato I, Akahane K, Inukai T, Takaori-Kondo A, Takita J, Ogawa S, Yusa K.
- Organizer
  日本血液学会国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04959
[Presentation] Canonical BAF complex is essential for the RUNX1-driven oncogenic transcriptional program in human T-cell acute lymphoblastic leukemia.2023
- Author(s)
  Aoki K, Hyuga M, Tarumoto Y, Nishibuchi G, Ochi Y, Sugino S, Mikami T, Kobushi H, Kato I, Akahane K, Inukai T, Takaori-Kondo A, Takita J, Ogawa S, Yusa K.
- Organizer
  日本がん学会学術総会
- Data Source
  KAKENHI-PROJECT-21H04959
[Presentation] CRISPR-KO スクリーニングの開発と応用2022
- Author(s)
  遊佐宏介
- Organizer
  第45回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-21H04959
[Presentation] Development of CRISPR-KO Screening and its Applications in Cancer Research2022
- Author(s)
  遊佐宏介
- Organizer
  IAAO2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04959
[Presentation] Development and Applications of CRISPR-KO Screening2022
- Author(s)
  遊佐宏介
- Organizer
  第31会日本がん転移学会学術集会・総会
- Invited
- Data Source
  KAKENHI-PROJECT-21H04959
[Presentation] CRISPR-KOスクリーニングの開発とがん研究への応用2021
- Author(s)
  遊佐宏介
- Organizer
  日本癌学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K20146
[Presentation] Genetic Dissection of Pluripotency Maintenance using CRISPR-KO Screening2021
- Author(s)
  遊佐宏介
- Organizer
  第110回日本病理学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21H04959
[Presentation] CRISPR-KOスクリーニングの開発と応用2021
- Author(s)
  遊佐宏介
- Organizer
  日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K20146
[Presentation] CRISPR-KOスクリーニングの開発と創薬研究への応用2021
- Author(s)
  遊佐宏介
- Organizer
  千里ライフサイエンスシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K20146
[Presentation] Development and Application of CRISPR-KO Screening2021
- Author(s)
  遊佐宏介
- Organizer
  第80会日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-21H04959
[Presentation] Development and Application of CRISPR-KO Screening2021
- Author(s)
  遊佐宏介
- Organizer
  第73回日本細胞生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-21H04959
[Presentation] Development and Application of CRISPR-KO Screening2021
- Author(s)
  遊佐宏介
- Organizer
  The 27th East Asia Joint Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04959
[Presentation] Development and Application of CRISPR-KO Screening2021
- Author(s)
  遊佐宏介
- Organizer
  第21回日本再生医療学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21H04959
[Presentation] CRISPR-KO スクリーニング法の開発と応用2019
- Author(s)
  遊佐宏介
- Organizer
  SULSA, Scottish Universities Life Science Alliance
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20146
[Presentation] CRISPR-KOスクリーニング法の開発と応用2019
- Author(s)
  遊佐宏介
- Organizer
  日本ゲノム編集学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K20146
[Presentation] CRISPR-KO スクリーニング法の開発と応用2019
- Author(s)
  遊佐宏介
- Organizer
  Frontiers in Genome Engineering 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20146
[Presentation] CRISPR-KOスクリーニング法の開発と応用2019
- Author(s)
  遊佐宏介
- Organizer
  日本遺伝学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K20146
[Presentation] 大規模全ゲノムCRISPRスクリーニングによる創薬候補の探索2018
- Author(s)
  遊佐宏介
- Organizer
  日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K20146
[Presentation] Identification of novel drug targets using CRISPR screens in cancer2018
- Author(s)
  遊佐宏介
- Organizer
  National Institute of Genetics
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20146
[Presentation] CRISPR-based genetic screening2018
- Author(s)
  遊佐宏介
- Organizer
  Croucher Summer Course Precision Genome Engineering by CRISPR
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20146
[Presentation] Oncology drug candidates identified from genome-wide CRISPR screens of 204 cancer cell lines2018
- Author(s)
  遊佐宏介
- Organizer
  日本癌学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K20146

1. 青木一成 (30618020)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. 下田和哉 (90311844)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 幣光太郎 (20468028)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 門之園哲哉 (10510282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 内田智士 (20710726)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 滝田順子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yusa Kosuke 遊佐 宏介

YUSA Kosuke 遊佐 宏介

Research Projects

Research Products

Co-Researchers

SWI/SNF合成致死遺伝子による造血器腫瘍新規治療戦略の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Generation and functional analysis of an awakening regulator for awakening quiescent cancer cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

腫瘍性fibrocyteの本態解明と、骨髄線維症診断・治療への展開

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

in vivo CRISPRスクリーニングの技術確立と生体内細胞増殖機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of human iPSC differentiation into definitive endoderm using CRISPR screeningPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Canonical BAF complex regulates the oncogenic program in human T-cell acute lymphoblastic leukemia2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] AKT-mTORC1 reactivation is the dominant resistance driver for PI3Kβ/AKT inhibitors in PTEN-null breast cancer and can be overcome by combining with Mcl-1 inhibitors2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Minimal genome-wide human CRISPR-Cas9 library.2021

Author(s)

Journal Title

DOI

Description

Data Source

[Presentation] Development and Applications of CRISPR-KO screening2023

Author(s)

Organizer

Data Source

[Presentation] Development and Applications of CRISPR-KO screening2023

Author(s)

Organizer

Data Source

[Presentation] Canonical BAF complex is essential for the RUNX1-driven oncogenic transcriptional program in human T-cell acute lymphoblastic leukemia2023

Author(s)

Organizer

Data Source

[Presentation] Canonical BAF complex is essential for the RUNX1-driven oncogenic transcriptional program in human T-cell acute lymphoblastic leukemia.2023

Author(s)

Organizer

Data Source

[Presentation] CRISPR-KO スクリーニングの開発と応用2022

Author(s)

Organizer

Data Source

[Presentation] Development of CRISPR-KO Screening and its Applications in Cancer Research2022

Author(s)

Organizer

Yusa Kosuke 遊佐宏介

YUSA Kosuke 遊佐宏介