Kimishima Yusuke 君島勇輔

Researcher Number	00836702
Affiliation (Current)	2025: 福島県立医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2023 – 2024: 福島県立医科大学, 医学部, 助教 2022: 福島県立医科大学, 医学部, 博士研究員 2019 – 2021: 福島県立医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related Except Principal Investigator Basic Section 53020:Cardiology-related
Keywords	Principal Investigator 血栓症 / JAK2 V617F / クローン性造血 / JAK2V617F / 肺高血圧症 / 肺動脈血管リモデリング / 好中球 / 心不全 / 静脈血栓症 / ACVRL1 … More / ALK1 / 骨髄増殖性腫瘍 / Pulmonary hypertension / 骨髄増殖性疾患 … More Except Principal Investigator HFpEF / クローン性造血 Less

クローン性造血から着想する心臓骨髄連関を介したHFpEFの分子病態機構
- Principal Investigator
  
  小河原崚
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Fukushima Medical University
静脈血栓症の新規治療標的としてのクローン性造血/JAK2－ALK1 axisの意義解明Principal Investigator
- Principal Investigator
  
  君島勇輔
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Fukushima Medical University
Understanding the Pathophysiology of Pulmonary Hypertension Based on the Dynamics of Pulmonary Neutrophil Differentiation and InflammationPrincipal Investigator
- Principal Investigator
  
  Kimishima Yusuke
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Fukushima Medical University
JAK2V617F mutation promotes chronic hypoxia-induced pulmonary hypertension in mice.Principal Investigator
- Principal Investigator
  
  Kimishima Yusuke
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Fukushima Medical University

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Targeting N-myristoylation through NMT2 prevents cardiac hypertrophy and heart failure2023
- Author(s)
  Tomita Y, Anzai F, Misaka T, Ogawara R, Ichimura S, Wada K, Kimishima Y, Yokokawa T, Ishida T, Takeishi Y
- Journal Title
  
  JACC Basic Transl Sci
  
  Volume: 8 Issue: 10 Pages: 1263-1282
- DOI
  10.1016/j.jacbts.2023.06.006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08036, KAKENHI-PROJECT-22K08107, KAKENHI-PROJECT-22K08161, KAKENHI-PROJECT-22K08211, KAKENHI-PROJECT-23K07557, KAKENHI-PROJECT-21K08112, KAKENHI-PROJECT-23K27600
[Journal Article] Clonal hematopoiesis and cardiovascular diseases: role of JAK2V617F2022
- Author(s)
  Misaka Tomofumi、Kimishima Yusuke、Yokokawa Tetsuro、Ikeda Kazuhiko、Takeishi Yasuchika
- Journal Title
  
  Journal of Cardiology
  
  Volume: - Issue: 1 Pages: 3-9
- DOI
  10.1016/j.jjcc.2022.02.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08365, KAKENHI-PROJECT-22K08107, KAKENHI-PROJECT-20K08428, KAKENHI-PROJECT-21K08112
[Journal Article] Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils2021
- Author(s)
  Kimishima Yusuke、Misaka Tomofumi、Yokokawa Tetsuro、Wada Kento、Ueda Koki、Sugimoto Koichi、Minakawa Keiji、Nakazato Kazuhiko、Ishida Takafumi、Oshima Motohiko、Koide Shuhei、Shide Kotaro、Shimoda Kazuya、Iwama Atsushi、Ikeda Kazuhiko、Takeishi Yasuchika
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 6177-6177
- DOI
  10.1038/s41467-021-26435-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08365, KAKENHI-PROJECT-19K08523, KAKENHI-PROJECT-19K08819, KAKENHI-PROJECT-19K17572, KAKENHI-PROJECT-20K17088, KAKENHI-PROJECT-20H03713, KAKENHI-PROJECT-20K08428, KAKENHI-PROJECT-20K08494, KAKENHI-PROJECT-21K08112, KAKENHI-PROJECT-21K08399
[Journal Article] Clonal Hematopoiesis and JAK2V617F Mutations in Patients With Cardiovascular Disease2021
- Author(s)
  Yokokawa Tetsuro、Misaka Tomofumi、Kimishima Yusuke、Wada Kento、Minakawa Keiji、Kaneshiro Takashi、Yoshihisa Akiomi、Ikeda Kazuhiko、Takeishi Yasuchika
- Journal Title
  
  JACC: CardioOncology
  
  Volume: 3 Issue: 1 Pages: 134-136
- DOI
  10.1016/j.jaccao.2021.01.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08365, KAKENHI-PROJECT-20K17088, KAKENHI-PROJECT-20K08428, KAKENHI-PROJECT-21K08112
[Journal Article] Blood-based epigenetic markers of FKBP5 gene methylation in patients with dilated cardiomyopathy.2021
- Author(s)
  Wada K, Misaka T, Yokokawa T, Kimishima Y, Kaneshiro T, Oikawa M, Yoshihisa A, Takeishi Y.
- Journal Title
  
  Journal of American Heart Association
  
  Volume: 10 Issue: 21
- DOI
  10.1161/jaha.121.021101
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08523, KAKENHI-PROJECT-19K17572, KAKENHI-PROJECT-20K17088, KAKENHI-PROJECT-21K08112
[Presentation] Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension through ALK12022
- Author(s)
  Yusuke Kimishima
- Organizer
  第86回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08112
[Presentation] Small hematopoietic clones with JAK2V617F causally lead to pulmonary hypertension through neutrophil selective migration and maturation from the precursors in the lungs2021
- Author(s)
  Yusuke Kimishima
- Organizer
  American Heart Association Scientific Session 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08112
[Presentation] Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension through ALK12021
- Author(s)
  君島勇輔
- Organizer
  第85回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17609
[Presentation] Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension through ALK12020
- Author(s)
  君島勇輔
- Organizer
  第24回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17609
[Presentation] Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension through ALK12020
- Author(s)
  君島勇輔
- Organizer
  iHFフォーラム
- Data Source
  KAKENHI-PROJECT-19K17609
[Presentation] JAK2V617F変異クローン性造血はALK1を介して肺高血圧症を増悪させる2020
- Author(s)
  君島勇輔
- Organizer
  第5回日本肺高血圧・肺循環学会
- Data Source
  KAKENHI-PROJECT-19K17609
[Presentation] Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension through ALK12020
- Author(s)
  君島勇輔
- Organizer
  American Heart Association Scientific Sessions 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17609
[Presentation] Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension through ALK12020
- Author(s)
  君島勇輔
- Organizer
  第4回日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-19K17609
[Presentation] Janus activating kinase 2 V617f mutation promotes hypoxia induced pulmonary hypertension in mice.2019
- Author(s)
  君島勇輔
- Organizer
  Scientific Sessions of American Heart Association 2019 (2019.11.16-11.18, Philadelphia, USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17609
[Presentation] JAK2 V617F mutation promotes hypoxia-induced pulmonary hypertension in mice2019
- Author(s)
  君島勇輔
- Organizer
  Cardiovascular and Metabolic Week 2019: International Society for Heart Research (ISHR), The 36th Annual Meeting of the Japanese Section (2019.12.14-12.15, Kobe, Japan)
- Data Source
  KAKENHI-PROJECT-19K17609
[Presentation] JAK2 V617F mutation promotes hypoxia-induced pulmonary hypertension in mice2019
- Author(s)
  君島勇輔
- Organizer
  2019 XXIII ISHR World Congress (2019.6.3-6.6, Beijing, China)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17609
[Presentation] JAK2 V617F mutation promotes hypoxia-induced pulmonary hypertension in mice2019
- Author(s)
  君島勇輔
- Organizer
  第3回日本循環器学会基礎研究フォーラム (The 3rd JCS Council Forum on Basic CardioVascular Research) (2019.9.6-9.8, 東京)
- Data Source
  KAKENHI-PROJECT-19K17609
[Presentation] JAK2 V617F mutation promotes hypoxia-induced pulmonary hypertension in mice2019
- Author(s)
  君島勇輔
- Organizer
  第23回　日本心不全学会学術集会 (2019.10.4-10.6, 広島)
- Data Source
  KAKENHI-PROJECT-19K17609

1. 三阪智史 (50793080)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. 植田航希 (80632190)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 池田和彦 (90381392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 小河原崚 (70971620)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 竹石恭知

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 横川哲朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Kimishima Yusuke 君島 勇輔

Research Projects

Research Products

Co-Researchers

クローン性造血から着想する心臓骨髄連関を介したHFpEFの分子病態機構

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

静脈血栓症の新規治療標的としてのクローン性造血/JAK2－ALK1 axisの意義解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding the Pathophysiology of Pulmonary Hypertension Based on the Dynamics of Pulmonary Neutrophil Differentiation and InflammationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

JAK2V617F mutation promotes chronic hypoxia-induced pulmonary hypertension in mice.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Targeting N-myristoylation through NMT2 prevents cardiac hypertrophy and heart failure2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clonal hematopoiesis and cardiovascular diseases: role of JAK2V617F2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clonal Hematopoiesis and JAK2V617F Mutations in Patients With Cardiovascular Disease2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Blood-based epigenetic markers of FKBP5 gene methylation in patients with dilated cardiomyopathy.2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension through ALK12022

Author(s)

Organizer

Data Source

[Presentation] Small hematopoietic clones with JAK2V617F causally lead to pulmonary hypertension through neutrophil selective migration and maturation from the precursors in the lungs2021

Author(s)

Organizer

Data Source

[Presentation] Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension through ALK12021

Author(s)

Organizer

Data Source

[Presentation] Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension through ALK12020

Author(s)

Organizer

Data Source

[Presentation] Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension through ALK12020

Author(s)

Organizer

Data Source

[Presentation] JAK2V617F変異クローン性造血はALK1を介して肺高血圧症を増悪させる2020

Author(s)

Organizer

Data Source

[Presentation] Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension through ALK12020

Author(s)

Organizer

Kimishima Yusuke 君島勇輔