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Kimishima Yusuke  君島 勇輔

ORCIDConnect your ORCID iD *help
Researcher Number 00836702
Affiliation (Current) 2026: 福島県立医科大学, 医学部, 博士研究員
Affiliation (based on the past Project Information) *help 2023 – 2024: 福島県立医科大学, 医学部, 助教
2022: 福島県立医科大学, 医学部, 博士研究員
2019 – 2021: 福島県立医科大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Basic Section 53020:Cardiology-related
Except Principal Investigator
Basic Section 53020:Cardiology-related
Keywords
Principal Investigator
血栓症 / 静脈血栓症 / ALK1 / JAK2 V617F / クローン性造血 / JAK2V617F / 肺高血圧症 / ALK1阻害薬 / JAK2V617F変異 / 肺動脈血管リモデリング … More / 好中球 / 心不全 / ACVRL1 / 骨髄増殖性腫瘍 / Pulmonary hypertension / 骨髄増殖性疾患 … More
Except Principal Investigator
HFpEF / クローン性造血 / 心不全 Less
  • Research Projects

    (4 results)
  • Research Products

    (37 results)
  • Co-Researchers

    (6 People)
  •  静脈血栓症の新規治療標的としてのクローン性造血/JAK2-ALK1 axisの意義解明Principal Investigator

    • Principal Investigator
      君島 勇輔
    • Project Period (FY)
      2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Fukushima Medical University
  •  クローン性造血から着想する心臓骨髄連関を介したHFpEFの分子病態機構

    • Principal Investigator
      小河原 崚
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Fukushima Medical University
  •  Understanding the Pathophysiology of Pulmonary Hypertension Based on the Dynamics of Pulmonary Neutrophil Differentiation and InflammationPrincipal Investigator

    • Principal Investigator
      Kimishima Yusuke
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Fukushima Medical University
  •  JAK2V617F mutation promotes chronic hypoxia-induced pulmonary hypertension in mice.Principal Investigator

    • Principal Investigator
      Kimishima Yusuke
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Fukushima Medical University

All 2025 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

  • [Journal Article] Reduced fetuin-A levels are associated with exercise intolerance and predict the risk of adverse outcomes in patients with heart failure: The role of cardiac-hepatic-peripheral interaction.2024

    • Author(s)
      Tomita Y, Misaka T, Sugawara Y, Ichijo Y, Anzai F, Sato Y, Kimishima Y, Yokokawa T, Sato T, Oikawa M, Kobayashi A, Yoshihisa A, Takeishi Y
    • Journal Title

      J Am Heart Assoc

      Volume: 13 Issue: 17

    • DOI

      10.1161/jaha.124.035139

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08036, KAKENHI-PROJECT-22K08107, KAKENHI-PROJECT-24K11272, KAKENHI-PROJECT-23K27600, KAKENHI-PROJECT-24K22124, KAKENHI-PROJECT-24K18648
  • [Journal Article] Impact of Cardio-Ankle Vascular Index on Future Cancer in Patients With Coronary Artery Disease2024

    • Author(s)
      Shimizu T, Sakuma Y, Muto Y, Anzai F, Kimishima Y, Sato Y, Sato A, Yokokawa T, Misaka T, Oikawa M, Yoshihisa A, Yamaki T, Nakazato K, Ishida T, Takeishi Y
    • Journal Title

      Circulation Reports

      Volume: 6 Issue: 9 Pages: 372-380

    • DOI

      10.1253/circrep.CR-24-0070

    • ISSN
      2434-0790
    • Year and Date
      2024-09-10
    • Language
      English
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08036, KAKENHI-PROJECT-22K08107, KAKENHI-PROJECT-24K11272, KAKENHI-PROJECT-23K07557, KAKENHI-PROJECT-23K15163, KAKENHI-PROJECT-24K18648
  • [Journal Article] Targeting N-myristoylation through NMT2 prevents cardiac hypertrophy and heart failure2023

    • Author(s)
      Tomita Y, Anzai F, Misaka T, Ogawara R, Ichimura S, Wada K, Kimishima Y, Yokokawa T, Ishida T, Takeishi Y
    • Journal Title

      JACC Basic Transl Sci

      Volume: 8 Issue: 10 Pages: 1263-1282

    • DOI

      10.1016/j.jacbts.2023.06.006

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08036, KAKENHI-PROJECT-22K08107, KAKENHI-PROJECT-22K08161, KAKENHI-PROJECT-22K08211, KAKENHI-PROJECT-23K07557, KAKENHI-PROJECT-21K08112, KAKENHI-PROJECT-23K27600
  • [Journal Article] Clonal hematopoiesis and cardiovascular diseases: role of JAK2V617F2022

    • Author(s)
      Misaka Tomofumi、Kimishima Yusuke、Yokokawa Tetsuro、Ikeda Kazuhiko、Takeishi Yasuchika
    • Journal Title

      Journal of Cardiology

      Volume: - Issue: 1 Pages: 3-9

    • DOI

      10.1016/j.jjcc.2022.02.001

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08365, KAKENHI-PROJECT-22K08107, KAKENHI-PROJECT-20K08428, KAKENHI-PROJECT-21K08112
  • [Journal Article] Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils2021

    • Author(s)
      Kimishima Yusuke、Misaka Tomofumi、Yokokawa Tetsuro、Wada Kento、Ueda Koki、Sugimoto Koichi、Minakawa Keiji、Nakazato Kazuhiko、Ishida Takafumi、Oshima Motohiko、Koide Shuhei、Shide Kotaro、Shimoda Kazuya、Iwama Atsushi、Ikeda Kazuhiko、Takeishi Yasuchika
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 6177-6177

    • DOI

      10.1038/s41467-021-26435-0

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08365, KAKENHI-PROJECT-19K08523, KAKENHI-PROJECT-19K08819, KAKENHI-PROJECT-19K17572, KAKENHI-PROJECT-20K17088, KAKENHI-PROJECT-20H03713, KAKENHI-PROJECT-20K08428, KAKENHI-PROJECT-20K08494, KAKENHI-PROJECT-21K08112, KAKENHI-PROJECT-21K08399
  • [Journal Article] Blood-based epigenetic markers of FKBP5 gene methylation in patients with dilated cardiomyopathy.2021

    • Author(s)
      Wada K, Misaka T, Yokokawa T, Kimishima Y, Kaneshiro T, Oikawa M, Yoshihisa A, Takeishi Y.
    • Journal Title

      Journal of American Heart Association

      Volume: 10 Issue: 21

    • DOI

      10.1161/jaha.121.021101

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08523, KAKENHI-PROJECT-19K17572, KAKENHI-PROJECT-20K17088, KAKENHI-PROJECT-21K08112
  • [Journal Article] Clonal Hematopoiesis and JAK2V617F Mutations in Patients With Cardiovascular Disease2021

    • Author(s)
      Yokokawa Tetsuro、Misaka Tomofumi、Kimishima Yusuke、Wada Kento、Minakawa Keiji、Kaneshiro Takashi、Yoshihisa Akiomi、Ikeda Kazuhiko、Takeishi Yasuchika
    • Journal Title

      JACC: CardioOncology

      Volume: 3 Issue: 1 Pages: 134-136

    • DOI

      10.1016/j.jaccao.2021.01.001

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08365, KAKENHI-PROJECT-20K17088, KAKENHI-PROJECT-20K08428, KAKENHI-PROJECT-21K08112
  • [Presentation] Very short-term blood pressure variability determined by pulse transit time predicts cardiac event in patients with heart failure2025

    • Author(s)
      Yu Sato, Akiomi Yoshihisa, Naoto Ohashi, Ryohei Takeishi, Toranosuke Sekine, Kazuto Nishiura, Ryo Ogawara, Shohei Ichimura, Yusuke Kimishima, Tetsuro Yokokawa, Shunsuke Miura, Tomofumi Misaka, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Kazuhiko Nakazato, Yasuchika Takeishi
    • Organizer
      第89回日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-24K11245
  • [Presentation] Very short-term blood pressure variability determined by pulse transit time predicts cardiac event in patients with heart failure2025

    • Author(s)
      Yu Sato, Akiomi Yoshihisa, Naoto Ohashi, Ryohei Takeishi, Toranosuke Sekine, Kazuto Nishiura, Ryo Ogawara, Shohei Ichimura, Yusuke Kimishima, Tetsuro Yokokawa, Shunsuke Miura, Tomofumi Misaka, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Kazuhiko Nakazato, Yasuchika Takeishi
    • Organizer
      第89回日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-24K11272
  • [Presentation] Systolic blood pressure during sleep determined by pulse transit time predicts cardiac event in patients with heart failure2025

    • Author(s)
      Naoto Ohashi, Akiomi Yoshihisa, Yu Sato, Ryohei Takeishi, Toranosuke Sekine, Kazuto Nishiura, Ryo Ogawara, Shohei Ichimura, Yusuke Kimishima, Tetsuro Yokokawa, Shunsuke Miura, Tomofumi Misaka, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Kazuhiko Nakazato, Yasuchika Takeishi
    • Organizer
      第89回日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-24K11272
  • [Presentation] Systolic blood pressure during sleep determined by pulse transit time predicts cardiac event in patients with heart failure2025

    • Author(s)
      Naoto Ohashi, Akiomi Yoshihisa, Yu Sato, Ryohei Takeishi, Toranosuke Sekine, Kazuto Nishiura, Ryo Ogawara, Shohei Ichimura, Yusuke Kimishima, Tetsuro Yokokawa, Shunsuke Miura, Tomofumi Misaka, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Kazuhiko Nakazato, Yasuchika Takeishi
    • Organizer
      第89回日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-24K11245
  • [Presentation] 閉塞性ショックを伴う急性肺血栓塞栓症に対し、カテーテル的血栓除去術が奏功した症例2025

    • Author(s)
      君島勇輔, 及川雅啓, 池田彩乃, 大橋尚人, 武藤雄紀, 横川哲朗, 佐藤彰彦, 清水竹史, 中里和彦, 竹石恭知
    • Organizer
      第56回日本心血管インターベンション治療学会 東北地方会
    • Data Source
      KAKENHI-PROJECT-24K11272
  • [Presentation] Systolic blood pressure during sleep determined by pulse transit time predicts worsening heart failure in patients with heart failure2024

    • Author(s)
      Naoto Ohashi, Akiomi Yoshihisa, Yu Sato, Ryohei Takeishi, Toranosuke Sekine, Kazuto Nishiura, Ryo Ogawara, Shohei Ichimura, Yusuke Kimishima, Tetsuro Yokokawa, Shunsuke Miura, Tomofumi Misaka, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Kazuhiko Nakazato, Yasuchika Takeishi
    • Organizer
      American Heart Association Scientific Sessions 2024
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24K11272
  • [Presentation] ポンプ内血栓が疑われた植込み型補助人工心臓の一例2024

    • Author(s)
      大河内諭, 佐藤崇匡, 西野笙汰, 小河原崚, 谷 哲矢, 八重樫大輝, 君島勇輔, 竹石恭知
    • Organizer
      第62回日本人工臓器学会大会
    • Data Source
      KAKENHI-PROJECT-24K11245
  • [Presentation] JAK2V617F変異クローン性造血を有するCTEPH患者にBPAを施行した一例2024

    • Author(s)
      君島勇輔, 三阪智史, 杉本浩一, 横川哲朗, 及川雅啓, 中里和彦, 竹石恭知
    • Organizer
      第32回日本心血管インターベンション治療学会学術集会(CVIT2024)
    • Data Source
      KAKENHI-PROJECT-24K11272
  • [Presentation] ポンプ内血栓が疑われた植込み型補助人工心臓の一例2024

    • Author(s)
      大河内諭, 佐藤崇匡, 西野笙汰, 小河原崚, 谷 哲矢, 八重樫大輝, 君島勇輔, 竹石恭知
    • Organizer
      第62回日本人工臓器学会大会
    • Data Source
      KAKENHI-PROJECT-24K11272
  • [Presentation] Systolic blood pressure during sleep determined by pulse transit time predicts worsening heart failure in patients with heart failure2024

    • Author(s)
      Naoto Ohashi, Akiomi Yoshihisa, Yu Sato, Ryohei Takeishi, Toranosuke Sekine, Kazuto Nishiura, Ryo Ogawara, Shohei Ichimura, Yusuke Kimishima, Tetsuro Yokokawa, Shunsuke Miura, Tomofumi Misaka, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Kazuhiko Nakazato, Yasuchika Takeishi
    • Organizer
      American Heart Association Scientific Sessions 2024
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24K11245
  • [Presentation] 循環Fetuin-A値の低下は心不全患者の運動耐容能低下と関連して心イベントを予測する2024

    • Author(s)
      冨田湧介, 三阪智史, 菅原由紀子, 安齋文弥, 佐藤 悠, 君島勇輔, 横川哲朗, 佐藤崇匡, 及川雅啓, 小林 淳, 義久精臣, 竹石恭知
    • Organizer
      第72回日本心臓病学会学術集会
    • Data Source
      KAKENHI-PROJECT-24K11272
  • [Presentation] JAK2-V617F変異による巨核球分化系統の変化により血小板機能の異常が生じる2024

    • Author(s)
      植田航希, 三阪智史, 君島勇輔, 松田将門, 佐藤友香, 皆川敬二, 竹石恭知, 池田和彦
    • Organizer
      第86回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-24K11272
  • [Presentation] 肺動脈性肺高血圧を合併した心房中隔欠損症に対してTreat and Repairを行った一例2024

    • Author(s)
      芳賀文香, 及川雅啓, 佐藤勇太朗, 池田彩乃, 武藤雄紀, 君島勇輔, 佐藤 悠, 横川哲朗, 小林 淳, 中里和彦, 石田隆史, 竹石恭知
    • Organizer
      第179回日本循環器学会東北地方会
    • Data Source
      KAKENHI-PROJECT-24K11272
  • [Presentation] Very short-term blood pressure variability determined by pulse transit time predicts major adverse cardiac and cerebrovascular event in patients with heart failure2024

    • Author(s)
      Yu Sato, Akiomi Yoshihisa, Naoto Ohashi, Ryohei Takeishi, Toranosuke Sekine, Kazuto Nishiura, Ryo Ogawara, Shohei Ichimura, Yusuke Kimishima, Tetsuro Yokokawa, Shunsuke Miura, Tomofumi Misaka, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Kazuhiko Nakazato, Yasuchika Takeishi
    • Organizer
      American Heart Association Scientific Sessions 2024
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24K11245
  • [Presentation] Very short-term blood pressure variability determined by pulse transit time predicts major adverse cardiac and cerebrovascular event in patients with heart failure2024

    • Author(s)
      Yu Sato, Akiomi Yoshihisa, Naoto Ohashi, Ryohei Takeishi, Toranosuke Sekine, Kazuto Nishiura, Ryo Ogawara, Shohei Ichimura, Yusuke Kimishima, Tetsuro Yokokawa, Shunsuke Miura, Tomofumi Misaka, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Kazuhiko Nakazato, Yasuchika Takeishi
    • Organizer
      American Heart Association Scientific Sessions 2024
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24K11272
  • [Presentation] バルーン肺動脈形成術が有効であったJAK2V617F変異クローン性造血を有する慢性血栓塞栓性肺高血圧症の一例2024

    • Author(s)
      鈴木喜敬, 君島勇輔, 三阪智史, 横川哲朗, 及川雅啓, 杉本浩一, 中里和彦, 石田隆史, 池田和彦, 竹石恭知
    • Organizer
      第179回日本循環器学会東北地方会
    • Data Source
      KAKENHI-PROJECT-24K11272
  • [Presentation] 冠動脈疾患患者におけるCardio-Ankle Vascular Indexの癌発症予測に関する検討2024

    • Author(s)
      清水竹史, 武藤雄紀, 佐藤 悠, 君島勇輔, 佐藤彰彦, 横川哲朗, 三阪智史, 義久精臣, 八巻尚洋, 中里和彦, 石田隆史, 竹石恭知
    • Organizer
      第72回日本心臓病学会学術集会
    • Data Source
      KAKENHI-PROJECT-24K11272
  • [Presentation] Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension through ALK12022

    • Author(s)
      Yusuke Kimishima
    • Organizer
      第86回 日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K08112
  • [Presentation] Small hematopoietic clones with JAK2V617F causally lead to pulmonary hypertension through neutrophil selective migration and maturation from the precursors in the lungs2021

    • Author(s)
      Yusuke Kimishima
    • Organizer
      American Heart Association Scientific Session 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08112
  • [Presentation] Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension through ALK12021

    • Author(s)
      君島勇輔
    • Organizer
      第85回日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K17609
  • [Presentation] Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension through ALK12020

    • Author(s)
      君島勇輔
    • Organizer
      第24回日本心不全学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K17609
  • [Presentation] Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension through ALK12020

    • Author(s)
      君島勇輔
    • Organizer
      iHFフォーラム
    • Data Source
      KAKENHI-PROJECT-19K17609
  • [Presentation] Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension through ALK12020

    • Author(s)
      君島勇輔
    • Organizer
      American Heart Association Scientific Sessions 2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K17609
  • [Presentation] Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension through ALK12020

    • Author(s)
      君島勇輔
    • Organizer
      第4回日本循環器学会基礎研究フォーラム
    • Data Source
      KAKENHI-PROJECT-19K17609
  • [Presentation] JAK2V617F変異クローン性造血はALK1を介して肺高血圧症を増悪させる2020

    • Author(s)
      君島勇輔
    • Organizer
      第5回日本肺高血圧・肺循環学会
    • Data Source
      KAKENHI-PROJECT-19K17609
  • [Presentation] JAK2 V617F mutation promotes hypoxia-induced pulmonary hypertension in mice2019

    • Author(s)
      君島勇輔
    • Organizer
      第23回 日本心不全学会学術集会 (2019.10.4-10.6, 広島)
    • Data Source
      KAKENHI-PROJECT-19K17609
  • [Presentation] JAK2 V617F mutation promotes hypoxia-induced pulmonary hypertension in mice2019

    • Author(s)
      君島勇輔
    • Organizer
      第3回 日本循環器学会基礎研究フォーラム (The 3rd JCS Council Forum on Basic CardioVascular Research) (2019.9.6-9.8, 東京)
    • Data Source
      KAKENHI-PROJECT-19K17609
  • [Presentation] JAK2 V617F mutation promotes hypoxia-induced pulmonary hypertension in mice2019

    • Author(s)
      君島勇輔
    • Organizer
      Cardiovascular and Metabolic Week 2019: International Society for Heart Research (ISHR), The 36th Annual Meeting of the Japanese Section (2019.12.14-12.15, Kobe, Japan)
    • Data Source
      KAKENHI-PROJECT-19K17609
  • [Presentation] Janus activating kinase 2 V617f mutation promotes hypoxia induced pulmonary hypertension in mice.2019

    • Author(s)
      君島勇輔
    • Organizer
      Scientific Sessions of American Heart Association 2019 (2019.11.16-11.18, Philadelphia, USA)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K17609
  • [Presentation] JAK2 V617F mutation promotes hypoxia-induced pulmonary hypertension in mice2019

    • Author(s)
      君島勇輔
    • Organizer
      2019 XXIII ISHR World Congress (2019.6.3-6.6, Beijing, China)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K17609
  • 1.  三阪 智史 (50793080)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 14 results
  • 2.  植田 航希 (80632190)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 3.  池田 和彦 (90381392)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 4.  小河原 崚 (70971620)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 5.  横川 哲朗
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 6.  竹石 恭知
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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