YAMADA Sachiko 山田幸子

Researcher Number	10014078
Other IDs
External Links
Affiliation (Current)	2022: 東京医科歯科大学, その他の部局等, 名誉教授 2022: 日本大学, 医学部, その他
Affiliation (based on the past Project Information) *help	2010: 日本大学, 医学部, 兼任講師 2009: 医学部, 兼任講師 2006 – 2008: 日本大学, 医学部, 客員教授 2005: Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Professor Emeritus, 生体材料工学研究所, 名誉教授 1999 – 2004: Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Professor, 生体材料工学研究所, 教授 1990 – 1998: 東京医科歯科大学, 医用器材研究所, 教授 1994: 東京医科歯科大学, 医用器材研, 教授
Review Section/Research Field	Principal Investigator 医薬分子機能学 / Chemical pharmacy Except Principal Investigator Chemical pharmacy / Biological Sciences / 神経・脳内生理学 / 医薬分子機能学 / Functional basic dentistry / Chemical pharmacy
Keywords	Principal Investigator ビタミンD / 合成 / 配座解析 / 構造活性相関 / 受容体 / 生理活性 / アナログ / 化学合成 / ビタミンD結合蛋白 / 活性型ビタミンD … More / Vitamin D / Analogs / ビタミンD代謝物 / 蛍光標識 / 蛍光性ジエノフィル / 蛍光分析 / トリアゾリンジオン / ビタミンA酸 / ビタミンA / Vitamin D metabolites / Fluorescence-labeling / Fluorescent dienophile / Fluorometry / Chemical synthesis / Triazolinediones / Retinoic acid / Vitamin A / アナローグ / 共役付加反応 / 合成アナローグ / 側鎖修飾体 / 有機銅試薬 / vitamin D / analog / synthesis / conformational analysis / structure activity relationship / conjugate addition / receptor / vitamin D binding protein / フッソ化 / 光異性化反応 / コンフォメーション / Receptor / Synthesis / Conformation analysis / Fluorination / Vitamin D binding protein / Photoisomerization / アナログ合成 / コンフォメーション解析 / フッ素化ビタミンD / フッ素NMR / ビタミンD受容体 / リガンド-受容体錯体 / 遺伝子組み替え / 配座制御 / 1,25-ジヒドロキシビタミンD_3 / Active vitamin D / Analog synthesis / Conformational analysis / Fluorovitamin D / ^<19>F NMR / Vitamin D receptor / Ligand-receptor complex / Recombinant DNA / 核内受容体 / ホモロジーモデリング / ノンステロイドビタミンD / 作用分離 / 三次元構造 / 遺伝子転写 / Nuclear receptor / Homology modeling / Non-steroid vitamin D / Differential action / Structure-function relationship / Three-dimensional structure … More Except Principal Investigator ビタミンD受容体 / ビタミンD / 核内受容体 / 炎症 / コンフォメーション解析 / 受容体結合活性 / ビタミンDアナログ / vitamin D / フッ素化ビタミンDアナログ / 活性型ビタミンD / ビタミンD-受容体複合体 / ^<19>F-NMR / ^<19>FNMR / Active vitamin D / Vitamin D receptor / Vitamin D-receptor complex / RANKL / RANK / TNF / PPAR / 遺伝子 / 蛋白質 / 脂質 / 発現制御 / 代謝 / セルセンサー / モーダルシフト / ダイオキシン受容体 / CYP1A1 / 胆汁鬱滞 / LXR / コファクター / 重力 / 胆汁酸 / 時計遺伝子 / 脂質代謝 / ビタミン / CYP1 / β-カテニン / 強心ステロイド / 転写調節 / 転写因子 / リトコール酸 / 蛍光性ジエノフィル / ビタミンD代謝物 / レチノイン酸 / マイクロシスチン / 蛍光アッセイ法 / 共役ジエン基 / 環化付加反応 / 化学発光 / 蛍光ラベル化 / 付加反応 / fluorescent dienophile / fluorometric assay / conjugated dienes / cycloaddition reaction / vitamin D metabolites / retinoic asid / microcystin / chemiluminescence / ニューロン活動 / 中枢神経系 / 光学的計測 / 三次計測 / 脳幹 / 神経核 / 光学切片法 / 脳皮質 / 三次元計測 / 光学的測定 / 電気活動 / optical recording / neural activity / three dimensional imaging / central nervous system / brain stem / 1,25-ジヒドロキシビタミンD3 / レセプター / 立体配座制御 / 配座制御アナログ / 遺伝子発現 / 1,25-ジヒドロキシビタミンD_3 / 有機銅試薬 / 面選択的共役付加反応 / 立体選択的 / 分子設計 / 分子力場計算 / ビタミンDレセプター / ビタミンD結合蛋白 / 1,25-dihydroxyvitamin D_3 / receptor / conformation analysis / conformational restriction / conformationally restricted analog / receptor binding affinity / gene expression / 活性立体配座 / 作用発現機構 / 活性型ビタミンD_3 / 19-フッ素化ビタミンD_3 / 4-フッ素化ビタミンD_3 / 活性立体配座解析 / Fluorovitamin D analog / Active conformation / Biological expression mechanism / 蛍光性ビタミンDアナログ / ビタミンDー受容体複合体 / コンフォメーション / ビタミンD-受容体コンプレックス / fluorovitamin D analog / Fluorescent-labeled vitamin D analog / ィイD119ィエD1FNMR / Conformational analysis / 腫瘍壊死因子(TNF) / 接触ポイント / 薬物開発 / 破骨細胞形成 / 骨量低下 / 構造生物学 / 破骨細胞形成抑制 / 環状ペプチド / CIAモデル / 炎症抑制 / 骨吸収抑制 / critical contact site / drug development / osteoclastogenesis / inflammation / bone loss / 1点変異体 / 遺伝子転写活性 / VDRE / オステオポンチン / VDR / vitamin D receptor / one-point mutant / vitamin D analog / transcriptional activity / 不飽和脂肪酸 / 光延反応 / ルシフェラーゼアッセイ / 医薬設計 / 生活習慣病 / 糖尿病 / 脂肪酸 / unsaturated fatty acid / Mitsunobu Reaction / luciferase assay / drug design / nuclear receptor / metabolic syndrome Less

Dynamic regulation of metabolite-sensing nuclear receptors
- Principal Investigator
  
  MAKISHIMA Makoto
- Project Period (FY)
  2006 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nihon University
Development of antidiabetic agents targeting PPARγ
- Principal Investigator
  
  YAMAMOTO Keiko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo Medical and Dental University
Studies on response element of vitamin D target genes and discrimination of vitamin D actions
- Principal Investigator
  
  YAMAMOTO Keiko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo Medical and Dental University
The epoch-making drug development of the inhibitor blocking inflammatory bone destruction in alveolar bones.
- Principal Investigator
  
  AOKI Kazuhiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Tokyo Medical and Dental University
De novo design and synthesis of aromatic vitamain D analogs having rigid three-dimensional structure and differential activityPrincipal Investigator
- Principal Investigator
  
  YAMADA Sachiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  医薬分子機能学
- Research Institution
  Tokyo Medical and Dental University
Three-dimensional structure of vitamin D ligand-receptor complex and its intracellular interaction
- Principal Investigator
  
  SHIMIZU Masato
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo Medical and Dental University
Active Vitamin D Analogs with Restricted Conformation Mobility : Synthesis, Receptor Binding and Regulation of Gene ExpressionPrincipal Investigator
- Principal Investigator
  
  YAMADA Sachiko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  医薬分子機能学
- Research Institution
  Tokyo Medical and Dental University
Confromational analysis of fluorovitamin D analogs interacting with vitamin D receptor using ^<19>F-NMR spectroscopy
- Principal Investigator
  
  SHIMIZU Masato
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo Medical and Dental University
Conformational Analysis of Vitamin D Resposible for Binding to VDR and DBP
- Principal Investigator
  
  YAMAMOTO Keiko
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Tokyo Medical and Dental University
Studies on the conformation of active form of vitamin D responsible for binding to the receptor and for expression of the activitiesPrincipal Investigator
- Principal Investigator
  
  YAMADA Sachiko
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Tokyo Medical and Dental University
Development of three-dimensional optical recording methods for neural activity in the central nervous system.
- Principal Investigator
  
  KAMINO Kohtaro
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  神経・脳内生理学
- Research Institution
  Tokyo Medical and Dental University
Design and Synthesis of New Sensitive Dienophiles, and Application to the Quantitative Analysis of Biologically Active Conjugated Dienes
- Principal Investigator
  
  SHIMIZU Masato
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo Medical and Dental University
Studies on the synthesis, conformational analysis, and biological activity of active vitamin D analogs in the purpose of developing therapeutic agent with selective activityPrincipal Investigator
- Principal Investigator
  
  YMADA Sachiko
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo Medical and Dental University
Syntheses and Application of the Functional Compounds Designed to Study the Metabolism and the Mechanism of the Action of Vitamin DPrincipal Investigator
- Principal Investigator
  
  YAMADA Sachiko
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo Medical and Dental University

All 2011 2010 2009 2008 2007 2004 Other

All Journal Article Presentation Patent

[Journal Article] Fluorescent retinoid X receptor ligands for fluorescence polarization assay2010
- Author(s)
  Yamada, S.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 20 Pages: 5143-5146
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D3 catabolism in macrophages.2009
- Author(s)
  Matsunawa M, Amano Y, Endo K, Uno S, Sakaki T, Yamada S, Makishima M.
- Journal Title
  
  Toxicol Sci 10
  
  Pages: 50-58
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia.2008
- Author(s)
  Ishizawa M, Matsunawa M, Adachi R, Uno S, Ikeda K, Masuno H, Shimizu M, Iwasaki K, Yamada S, Makishima M
- Journal Title
  
  J Lipid Res 49
  
  Pages: 763-772
- NAID
  110007575062
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia.2008
- Author(s)
  Ishizawa M, Matsunawa M, Adachi R, Uno S, Ikeda K, Masuno H, Shimizu M, Iwasaki K, Yamada S, Makishima M.
- Journal Title
  
  J Lipid Res 49
  
  Pages: 763-772
- NAID
  110007575062
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Inhibition of aryl hydrocarbon receptor transactivation and DNA adduct formation by CYP1 isoform-selective metabolic deactivation of benzo[a]pyrene.2008
- Author(s)
  Endo K, Uno S, Seki T, Ariga T, Kusumi Y, Mitsumata M, Yamada S, Makishima M.
- Journal Title
  
  Toxicol Appl Pharmacol 230
  
  Pages: 135-143
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Vitamin D3 derivatives with adamantane or lactone ring side chains are cell type-selective vitamin D receptor modulators.2007
- Author(s)
  Inaba Y, Yamamoto K, Yoshimoto N, Matsunawa M, Uno S, Yamada S, Makishima M
- Journal Title
  
  Mol Pharmacol 71
  
  Pages: 1298-1311
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Vitamin D3 derivatives with adamantane or lactone ring side chains are cell type-selective vitamin D receptor modulators.2007
- Author(s)
  Inaba Y, Yamamoto K, Yoshimoto N, Matsunawa M, Uno S, Yamada S, Makishima M.
- Journal Title
  
  Mol Pharmacol 71
  
  Pages: 1298-1311
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Journal Article] Two-dimensional alanine scanning mutational analysis of the interaction between the vitamin d receptor and its ligands : Studies of A2004
- Author(s)
  Shimizu M, Yamamoto_K, Mihori M, Iwasaki Y, Morizono D, Yamada, S
- Journal Title
  
  The Journal of Steroid Biochemistry and Molecular Biology 89-90
  
  Pages: 75-81
- Data Source
  KAKENHI-PROJECT-16590003
[Journal Article] The aryl hydrocarbon receptor activator benzo [a] pyrene enhances vitamin D3 catabolism in macrophages.
- Author(s)
  Matsunawa M, Amano Y, Endo K, Uno S, Sakaki T, Yamada S, Makishima M
- Journal Title
  
  Toxicol Sci (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077005
[Patent] パーシャルアゴニスト活性を持つ新規ビタミンD受容体モジュレーター2011
- Inventor(s)
  槇島誠、山田幸子、常盤広明、工藤健
- Industrial Property Rights Holder
  学校法人日本大学、学校法人立教学院
- Industrial Property Number
  2011-045022
- Filing Date
  2011-03-02
- Data Source
  KAKENHI-PLANNED-18077005
[Patent] 作用選択的ビタミンD 受容体作用剤2008
- Inventor(s)
  槇島誠、石澤通康、松縄学、山田幸子
- Industrial Property Rights Holder
  学校法人日本大学
- Filing Date
  2008-01-07
- Overseas
- Data Source
  KAKENHI-PLANNED-18077005
[Patent] 作用選択的ビタミンD受容体作用剤2007
- Inventor(s)
  槇島誠、石澤通康、松縄学、山田幸子
- Industrial Property Rights Holder
  学校法人日本大学
- Industrial Property Number
  2007-147866
- Filing Date
  2007-06-04
- Data Source
  KAKENHI-PLANNED-18077005
[Presentation] X-ray crystal structures, biological activity and structure-activity relationships of novel vitamin D partial agonists/antagonists2009
- Author(s)
  Yamada, S.
- Organizer
  14th Workshop on Vitamin D
- Place of Presentation
  Brugge, Belgium
- Data Source
  KAKENHI-PLANNED-18077005
[Presentation] アダマンチルビタミンD誘導体を結合したビタミンD受容体の結晶構造2008
- Author(s)
  山田幸子
- Organizer
  第321回脂溶性ビタミン総合研究委員会
- Place of Presentation
  東京
- Year and Date
  2008-09-26
- Data Source
  KAKENHI-PLANNED-18077005

1. YAMAMOTO Keiko (90147017)

# of Collaborated Projects: 10 results

# of Collaborated Products: 1 results
2. SHIMIZU Masato (50126231)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
3. MAKISHIMA Makoto (70346146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
4. UNO Shigeyuki (90307851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
5. NISHIDA Shigeru (90211458)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. CHOI Mihwa (30571012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ENDO Kaori (10445744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. CHO Yoshitake (70468742)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KAMINO Kohtaro (40025630)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SAKAI Yoko (70251501)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SAKAI Tetsuro (40153845)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. AOKI Kazuhiro (40272603)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. AZUMA Miyuki (90255654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TAKAHASHI Mariko (90334440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 廣田秋彦 (50156717)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. ISHIZAWA MICHIYASU

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. KAWANA Katsuyoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. AMANO Yusuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. OGURA Michitaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. OGEKI Jun

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. SATO Katsushige

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. WAKI Yoshihiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. NONAKA Kiichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. DELUCA Hecto

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. DELUCA H.F.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. REISCHL Wolfgang

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YAMADA Sachiko 山田 幸子

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De novo design and synthesis of aromatic vitamain D analogs having rigid three-dimensional structure and differential activityPrincipal Investigator

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Active Vitamin D Analogs with Restricted Conformation Mobility : Synthesis, Receptor Binding and Regulation of Gene ExpressionPrincipal Investigator

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Studies on the conformation of active form of vitamin D responsible for binding to the receptor and for expression of the activitiesPrincipal Investigator

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Studies on the synthesis, conformational analysis, and biological activity of active vitamin D analogs in the purpose of developing therapeutic agent with selective activityPrincipal Investigator

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Syntheses and Application of the Functional Compounds Designed to Study the Metabolism and the Mechanism of the Action of Vitamin DPrincipal Investigator

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[Journal Article] Fluorescent retinoid X receptor ligands for fluorescence polarization assay2010

YAMADA Sachiko 山田幸子