Yamamoto Keiko 山本恵子

… Alternative Names

Researcher Number	90147017
Other IDs
External Links
Affiliation (Current)	2018 : 昭和薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2007 – 2017 : 昭和薬科大学, 薬学部, 教授 2005 : Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Associate Professor, 生体材料工学研究所, 助教授 2004 : 東京医科歯科大学, 生体材料工学研究所, 教授 2003 : Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Instructor, 生体材料工学研究科, 助手 1999 – 2003 : Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Instructor, 生体材料工学研究所, 助手 … More
Review Section/Research Field	Principal Investigator Drug development chemistry / Chemical pharmacy / Chemical pharmacy / 医薬分子機能学 Except Principal Investigator Chemical pharmacy / 医薬分子機能学 / Living organism molecular science / Hematology
Keywords	Principal Investigator ビタミンD / ビタミンD受容体 / 核内受容体 / アゴニスト / 結晶構造解析 / ビタミンＤ / PPAR / アンタゴニスト / ビタミンDアナログ / vitamin D … More Except Principal Investigator ビタミンD / 活性型ビタミンD / 合成 / 構造活性相関 / アナログ / 配座解析 / 受容体 / Active vitamin D / 生理活性 / ビタミンD受容体 / Vitamin D receptor / ^<19>F-NMR / tissue factor / コンフォメーション解析 / ビタミンD結合蛋白 / Conformational analysis / コンフォメーション / 核内受容体 / フッ素化ビタミンDアナログ / ビタミンD-受容体複合体 / Vitamin D / ^<19>FNMR / gene transfer / Vitamin D-receptor complex / Analogs / plasmin inhibitor / thrombomodulin / 三次元構造 / フッソ化 / 疎水性ファーマコフォア / 蛍光性ビタミンDアナログ / 化学発光 / Synthesis / プラスミンインヒビター / 作用発現機構 / 組織因子 / protein C / vitamin D / 光異性化反応 / 環化付加反応 / Differential action / 4-フッ素化ビタミンD_3 / ビタミンD代謝物 / Fluorovitamin D analog / non-viral gene transfer / Fluorescent-labeled vitamin D analog / Non-steroid vitamin D / structure activity relationship / 蛍光プローブ / vitamin D metabolites / アンドロゲン / 蛍光性ジエノフィル / retinoic asid / ^<19>F NMR / フッ素NMR / 配座制御 / conjugated dienes / 活性立体配座解析 / カルボラン / analog / conjugate addition / microcystin / トロンボモジュリン / 化合物ライブラリー / factor VII activating enzyme / 遺伝子組み替え / 受容体結合活性 / chemiluminescence / Ligand-receptor complex / Recombinant DNA / ノンステロイドビタミンD / Analog synthesis / 19-フッ素化ビタミンD_3 / プロゲステロン / Active conformation / 1,25-ジヒドロキシビタミンD_3 / receptor / ビタミンD-受容体コンプレックス / vitamin D binding protein / ィイD119ィエD1FNMR / 共役ジエン基 / アナログ合成 / リガンド-受容体錯体 / 活性立体配座 / 遺伝子転写 / レチノイド / synthesis / Fluorovitamin D / フッ素化ビタミンD / Photoisomerization / tumor necrosis factor / 有機銅試薬 / アナローグ / 蛍光ラベル化 / Fluorination / 作用分離 / Receptor / fluorometric assay / Homology modeling / 付加反応 / レチノイン酸 / 合成アナローグ / fluorescent dienophile / Biological expression mechanism / 活性型ビタミンD_3 / 側鎖修飾体 / Nuclear receptor / conformational analysis / Structure-function relationship / Conformation analysis / Vitamin D binding protein / マイクロシスチン / fluorovitamin D analog / 化学合成 / 遺伝子転写制御 / 不飽和脂肪酸 / 蛍光性リガンド / ケミカルバイオロジー / ビタミンDー受容体複合体 / Three-dimensional structure / 共役付加反応 / cycloaddition reaction / ホモロジーモデリング / 蛍光アッセイ法 Less

ビタミンD受容体コファクターペプチドの網羅的合成と機能解析Principal InvestigatorOngoing
- Principal Investigator
  
  山本恵子
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Showa Pharmaceutical University
Development of reversible covalent vitamin D receptor ligandsPrincipal Investigator
- Principal Investigator
  
  Yamamoto Keiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Showa Pharmaceutical University
Discovery of ligands that modulate the pocket structure of vitamin D receptorPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Keiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Showa Pharmaceutical University
Role of ligands for allosteric network of nuclear receptorsPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Keiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Showa Pharmaceutical University
Chemical biological approach for regulation of gene expression
- Principal Investigator
  
  KAGECHIKA Hiroyuki
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Living organism molecular science
- Research Institution
  Tokyo Medical and Dental University
Development of antidiabetic agents targeting PPARγPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Keiko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo Medical and Dental University
Studies on response element of vitamin D target genes and discrimination of vitamin D actionsPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Keiko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo Medical and Dental University
Regulation of tissue factor and thrombomodulin expressions
- Principal Investigator
  
  KOYAMA Takatoshi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical and Dental University
De novo design and synthesis of aromatic vitamain D analogs having rigid three-dimensional structure and differential activity
- Principal Investigator
  
  YAMADA Sachiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  医薬分子機能学
- Research Institution
  Tokyo Medical and Dental University
Three-dimensional structure of vitamin D ligand-receptor complex and its intracellular interaction
- Principal Investigator
  
  SHIMIZU Masato
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo Medical and Dental University
Active Vitamin D Analogs with Restricted Conformation Mobility : Synthesis, Receptor Binding and Regulation of Gene Expression
- Principal Investigator
  
  YAMADA Sachiko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  医薬分子機能学
- Research Institution
  Tokyo Medical and Dental University
Confromational analysis of fluorovitamin D analogs interacting with vitamin D receptor using ^<19>F-NMR spectroscopy
- Principal Investigator
  
  SHIMIZU Masato
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo Medical and Dental University
Conformational Analysis of Vitamin D Resposible for Binding to VDR and DBPPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Keiko
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Tokyo Medical and Dental University
Studies on the conformation of active form of vitamin D responsible for binding to the receptor and for expression of the activities
- Principal Investigator
  
  YAMADA Sachiko
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Tokyo Medical and Dental University
Design and Synthesis of New Sensitive Dienophiles, and Application to the Quantitative Analysis of Biologically Active Conjugated Dienes
- Principal Investigator
  
  SHIMIZU Masato
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo Medical and Dental University
Studies on the synthesis, conformational analysis, and biological activity of active vitamin D analogs in the purpose of developing therapeutic agent with selective activity
- Principal Investigator
  
  YMADA Sachiko
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo Medical and Dental University

All 2017 2016 2015 2014 2013 2012 2011 2010 2009 2005 2004 Other

All Journal Article Presentation

[Journal Article] SRC2-3 binds to vitamin D receptor with high sensitivity and strong affinity.2017
- Author(s)
  Egawa D, Itoh T, Kato A, Kataoka S, Anami Y, Yamamoto K.
- Journal Title
  
  Bioorg Med Chem.
  
  Volume : 25 Pages : 568-574
- DOI
  10.1016/j.bmc.2016.11.020
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460155
[Journal Article] Vitamin D Analogues with a p-Hydroxyphenyl Group at the C25 Position: Crystal Structure of Vitamin D Receptor Ligand-Binding Domain Complexed with the Ligand Explains the Mechanism Underlying Full Antagonistic Action2017
- Author(s)
  Kato Akira、Yamao Makiko、Hashihara Yuta、Ishida Hiroaki、Itoh Toshimasa、Yamamoto Keiko
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume : 60 Pages : 8394-8406
- DOI
  10.1021/acs.jmedchem.7b00819
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08373
[Journal Article] Helix12-stabilization antagonist of vitamin D receptor2016
- Author(s)
  Kato A, Anami Y, Egawa D, Itoh T, Yamamoto K.
- Journal Title
  
  Bioconjugate Chem.
  
  Volume : 27 Pages : 1750-1761
- DOI
  10.1021/acs.bioconjchem.6b00246
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460155
[Journal Article] Apo- and Antagonist-Binding Structures of Vitamin D Receptor Ligand-Binding Domain Revealed by Hybrid Approach Combining Small-Angle X-ray Scattering and Molecular Dynamics.2016
- Author(s)
  Anami Y, Shimizu N, Ekimoto T, Egawa D, Itoh T, Ikeguchi M, Yamamoto K.
- Journal Title
  
  J. Med. Chem.
  
  Volume : 59 Pages : 7888-7900
- DOI
  10.1021/acs.jmedchem.6b00682
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460155
[Journal Article] Fine tuning of agonistic/antagonistic activity for vitamin D receptor by 22-alkyl chain length of ligands: 22S-Hexyl compound unexpectedly restored agonistic activity2015
- Author(s)
  Anami Y, Sakamaki Y, Itoh T, Inaba Y, Nakabayashi M, Ikura T, Ito N, Yamamoto K.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume : 23 Pages : 7274-7281
- DOI
  10.1016/j.bmc.2015.10.026
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460155
[Journal Article] A mixed population of antagonist and agonist binding conformers in a single crystal explains partial agonism against vitamin D receptor : Active vitamin D analogues with 22R-alkyl group2014
- Author(s)
  Anami Y, Itoh T, Egawa D, Yoshimoto N, Yamamoto K.
- Journal Title
  
  J. Med. Chem
  
  Volume : 57 Pages : 4351-4367
- DOI
  10.1021/jm500392t
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590135, KAKENHI-PROJECT-26460155
[Journal Article] ビタミンDと関連タンパク質(CYP,DBP,VDR)の構造生命科学2013
- Author(s)
  山本恵子
- Journal Title
  
  ビタミン
  
  Volume : 87 Pages : 669-677
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590135
[Journal Article] Butyl pocket formation in the vitamin D receptor strongly affects the agonistic or antagonistic behavior of ligands2012
- Author(s)
  Yoshimoto N, Sakamaki Y, Haeta M, Kato A, Inaba Y, Itoh T, Nakabayashi M, Ito N, Yamamoto K
- Journal Title
  
  J. Med. Chem
  
  Volume : 55 Pages : 4373-4381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590135
[Journal Article] Butyl Pocket Formation in the Vitamin D Receptor Strongly Affects the Agonistic or Antagonistic Behavior of Ligand.2012
- Author(s)
  Yoshimoto N, Sakamaki Y, Haeta M, Kato A, Inaba Y, Itoh T, Nakabayashi M, Ito N, Yamamoto K.
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume : 55 Pages : 4373-4381
- DOI
  10.1021/jm300230a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590135
[Journal Article] 22S-Butyl-1α, 24R-dihydroxyvitamin D3 : Recovery of vitamin D receptor agonistic activity.2010
- Author(s)
  Inaba Y, Nakabayashi M, Itoh T, Yoshimoto N, Ikura T, Ito N, Shimizu M, Yamamoto K.
- Journal Title
  
  J.Steroid Biochem.Mol.Biol. 121
  
  Pages : 146-150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590108
[Journal Article] Synthesis of oxidized fatty acid derivatives via an iodolactonization reaction.2010
- Author(s)
  Itoh T, Yoshimoto N, Yamamoto K.
- Journal Title
  
  Heterocycles. 80
  
  Pages : 689-695
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590108
[Journal Article] Potent Antagonist for the Vitamin D Receptor : Vitamin D Analogues with Simple Side Chain Structure.2010
- Author(s)
  Sakamaki Y, Inaba Y, Yoshimoto N, Yamamoto K.
- Journal Title
  
  J.Med.Chem. 53
  
  Pages : 5813-5826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590108
[Journal Article] Flexible Ligand Recognition of Peroxisome Proliferator-Activated Receptor-γ (PPARγ).2010
- Author(s)
  Yamagishi K, Yamamoto K, Mochizuki Y, Nakano T, Yamada S, Tokiwa H.
- Journal Title
  
  Bioorg Med Chem.Lett. 20
  
  Pages : 3344-3347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590108
[Journal Article] Activation of Testicular Orphan Receptor 4 by Fatty Acids.2009
- Author(s)
  Tsai N-P, Huq M, Gupta P, Yamamoto K, Kagechika H, Wei L-N.
- Journal Title
  
  Biochim.Biophys.Acta, Gene Regul.Mech. 1789
  
  Pages : 734-740
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590108
[Journal Article] Contribution of AP-1 interference induced by TAC-101 to tumor growth suppression in a hepatocellular carcinoma model2009
- Author(s)
  Eshima, K., Fukaya S., Sugimoto, A., Mori, T., Yokoi, H., Yamamoto, Y., Sugiura, S., Honda, S., Masuko, N., Murakami, K., Yamasaki, Y., Kagechika, H.
- Journal Title
  
  Tumor Biol. 30
  
  Pages : 1-7
- Data Source
  KAKENHI-PROJECT-19201044
[Journal Article] Activation of Testicular Orphan Receptor 4 by Fatty Acids2009
- Author(s)
  Tsai, N.-P., Huq, M., Gupta, P., Yamamoto, K., Kagechika, H., Wei, L.-N.
- Journal Title
  
  Biochim.Biophys.Acta-Gene Regul.Mech. 1789
  
  Pages : 734-740
- Data Source
  KAKENHI-PROJECT-19201044
[Journal Article] Contribution of AP-1 interference induced by TAC-101 totumor growth suppression in ahepatocellular carcinoma model2009
- Author(s)
  Eshima, K.; Fukaya S.; Sugimoto, A.; Mori, T.; Yokoi, H.; Yamamoto, Y.; Sugiura, S.; Honda, S.; Masuko, N.; Murakami, K.; Yamasaki, Y.; Kagechika, H.
- Journal Title
  
  TumorBiol
  
  Volume : 30 Pages : 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19201044
[Journal Article] A New Class of Vitamin D Analogues that Induce Structural Rearrangement of the Ligand-Binding Pocket of the Receptor.2009
- Author(s)
  Inaba Y, Yoshimoto N, Sakamaki Y, Nakabayashi M, Ikura T, Tamamura H, Ito N, Shimizu M, Yamamoto K.
- Journal Title
  
  J.Med.Chem. 52
  
  Pages : 1438-1449
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590108
[Journal Article] Activation of Testicular Orphan Receptor4 by Fatty Acids2009
- Author(s)
  Tsai, N.-P.; Huq, M.; Gupta, P.; Yamamoto, K.; Kagechika, H.; Wei, L.-N.
- Journal Title
  
  Biochim. Biophys. Acta-Gene Regul. Mech
  
  Volume : 1789 Pages : 734-740
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19201044
[Journal Article] Identification of Putative Metabolites of Docosahexaenoic Acid as Potent PPARγ Agonists and Antidiabetic Agents.2005
- Author(s)
  Yamamoto_K, Itoh T, Abe D, Shimizu M, Kanda T, Kovama T, Ni
- Journal Title
  
  Bioorganic Medicinal Chemistry Letters 15
  
  Pages : 517-522
- Data Source
  KAKENHI-PROJECT-16590003
[Journal Article] Identification of Putative Metabolites of Docosahexaenoic Acid as Potent PPARγ Agonists and Antidiabetic Agents.2005
- Author(s)
  Keiko Yamamoto
- Journal Title
  
  Bioorganic Medicinal Chemistry Letters. 15
  
  Pages : 517-522
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590003
[Journal Article] Identification of Putative Metabolites of Docosahexaenoic Acid as Potent PPARγ Agonists and Antidiabetic Agents2005
- Author(s)
  Keiko Yamamoto
- Journal Title
  
  Bioorganic Medicinal Chemistry Letters 15
  
  Pages : 517-522
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590003
[Journal Article] Identification of Putative Metabolites of Docosahexaenoic Acid as Pot ent PPARγ Agonists and Antidiabetic Agents.2005
- Author(s)
  Keiko Yamamoto
- Journal Title
  
  Bioorganic Medicinal Chemistry Letters 15
  
  Pages : 517-522
- Data Source
  KAKENHI-PROJECT-16590003
[Journal Article] Two-dimensional alanine scanning mutational analysis of the interaction between the vitamin d receptor and its ligands : Studies of A2004
- Author(s)
  Shimizu M, Yamamoto_K, Mihori M, Iwasaki Y, Morizono D, Yamada, S
- Journal Title
  
  The Journal of Steroid Biochemistry and Molecular Biology 89-90
  
  Pages : 75-81
- Data Source
  KAKENHI-PROJECT-16590003
[Presentation] Crystal structure of vitamin D receptor ligand-binding domain complexed with antagonist2017
- Author(s)
  Keiko Yamamoto, Akira Kato, Toshimasa Itoh
- Organizer
  The 18th Tetrahedron Symposium (Budapest)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08373
[Presentation] 側鎖に電子求引基をもつ活性型ビタミンD誘導体の設計と合成2016
- Author(s)
  吉澤麻美、堀竜也、穴見康昭、加藤晃、吉本暢子、伊藤俊将、山本恵子
- Organizer
  日本薬学会第136年会
- Place of Presentation
  神奈川県横浜市　パシフィコ横浜
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-26460155
[Presentation] ビタミンD受容体と電子求引基を有するリガンド間の共有結合形成2016
- Author(s)
  吉澤麻美、堀竜也、穴見康昭、加藤晃、吉本暢子、伊藤俊将、山本恵子
- Organizer
  第27回日本レチノイド研究会学術集会
- Place of Presentation
  東京都町田市　昭和薬科大学
- Year and Date
  2016-10-22
- Data Source
  KAKENHI-PROJECT-26460155
[Presentation] アンタゴニスト結合による VDR の構造変化 : HDX 解析と結晶構造解析を用いて2016
- Author(s)
  加藤晃、伊藤俊将、山本恵子
- Organizer
  日本ビタミン学会第68回大会
- Place of Presentation
  富山県富山市（富山国際会議場）
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-26460155
[Presentation] ビタミンD受容体と共有結合するリガンドの創製研究2014
- Author(s)
  山本恵子、吉澤麻美、吉本暢子、穴見康昭、江川大地、伊藤俊将
- Organizer
  日本ビタミン学会第６６回大会
- Place of Presentation
  兵庫県・姫路商工会議所
- Year and Date
  2014-06-14
- Data Source
  KAKENHI-PROJECT-26460155
[Presentation] 結晶構造に基づくビタミンD受容体パーシャルアゴニスト作用の分子基盤研究2014
- Author(s)
  穴見康昭、伊藤俊将、山本恵子
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本、熊本大学
- Year and Date
  2014-03-28
- Data Source
  KAKENHI-PROJECT-23590135
[Presentation] ビタミンD受容体の活性コンフォメーション形成を阻止するスーパーアンタゴニストの創製研究2013
- Author(s)
  加藤晃、吉本暢子、伊藤俊将、山本恵子
- Organizer
  第24回日本レチノイド研究会学術集会
- Place of Presentation
  東京、星薬科大学
- Year and Date
  2013-08-30
- Data Source
  KAKENHI-PROJECT-23590135
[Presentation] ビタミンD受容体の活性型コンフォメーションを阻止するリガンドの設計2013
- Author(s)
  加藤晃、吉本暢子、穴見康昭、江川大地、伊藤俊将、山本恵子
- Organizer
  合成と生物活性日本薬学会第133年会
- Place of Presentation
  神奈川、パシフィコ横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-23590135
[Presentation] 側鎖に求電子基をもつビタミンD誘導体の設計と合成2013
- Author(s)
  吉澤麻美、吉本暢子、穴見康昭、江川大地、伊藤俊将、山本恵子
- Organizer
  第57回日本薬学会関東支部大会
- Place of Presentation
  東京、帝京大学
- Year and Date
  2013-10-26
- Data Source
  KAKENHI-PROJECT-23590135
[Presentation] 22R-アルキルビタミンD誘導体/受容体複合体のX線結晶構造解析2013
- Author(s)
  穴見康昭、吉本暢子、伊藤俊将、山本恵子
- Organizer
  日本ケミカルバイオロジー学会第8回年会
- Place of Presentation
  東京、東京医科歯科大学
- Year and Date
  2013-06-20
- Data Source
  KAKENHI-PROJECT-23590135
[Presentation] Synthesis and Characterization of Active Vitamin D Analogues with 22R-alkyl Group2013
- Author(s)
  Yasuaki Anami, Nobuko Yoshimoto, Toshimasa Itoh, Keiko Yamamoto
- Organizer
  14^<th> Tetrahedron Symposium
- Place of Presentation
  Vienna
- Year and Date
  2013-06-26
- Data Source
  KAKENHI-PROJECT-23590135
[Presentation] 22R-アルキル活性型ビタミンD誘導体の合成と生物活性評価2012
- Author(s)
  穴見康昭、酒巻雄太、加藤晃、吉本暢子、伊藤俊将、山本恵子
- Organizer
  第23回日本レチノイド研究会学術集会
- Place of Presentation
  鳥取、米子コンベンションセンター
- Year and Date
  2012-10-19
- Data Source
  KAKENHI-PROJECT-23590135
[Presentation] I268T変異.ビタミンD受容体のリガンド結合ドメインの結晶構造2012
- Author(s)
  中林誠、島崎美佳、増野弘幸、清水正人、山本恵子、伊倉貞吉、伊藤暢聡
- Organizer
  日本ビタミン学会第64回大会
- Place of Presentation
  岐阜、長良川国際会議場
- Year and Date
  2012-06-23
- Data Source
  KAKENHI-PROJECT-23590135
[Presentation] 3つのオキソ型脂肪酸のPPARγへの結合様式の比較2011
- Author(s)
  伊藤俊将,吉本暢子,山本恵子
- Organizer
  日本薬学会第131年会
- Place of Presentation
  (要旨集上にて発表)
- Year and Date
  2011-03-05
- Data Source
  KAKENHI-PROJECT-20590108
[Presentation] Vitamin D Analogs with Simple Side Chain Structure: Agonists, Partial Agonists, and Antagonists for the Vitamin D Receptor2011
- Author(s)
  Keiko Yamamoto, Yuta Sakamaki, Yuka Inaba, Nobuko Yoshimoto, Toshimasa Itoh, Makoto Nakabayashi, Teikichi Ikura, Nobutoshi Ito
- Organizer
  AIMECS 11 (The 8th AFMC International Medicinal Chemistry Symposium)
- Place of Presentation
  東京（京王プラザホテル）
- Data Source
  KAKENHI-PROJECT-23590135
[Presentation] 22R-ブチル活性型ビタミンD誘導体の合成と生物活性評価2011
- Author(s)
  穴見康昭、酒巻雄太、蝿田稔、吉本暢子、伊藤俊将、山本恵子
- Organizer
  ビタミン学会第63回大会
- Place of Presentation
  広島、安田女子大学
- Year and Date
  2011-06-05
- Data Source
  KAKENHI-PROJECT-23590135
[Presentation] Vitamin D Analogs with Simple Side Chain Structure : Agonists, Partial Agonists, and Antagonists for the Vitamin D Receptor2011
- Author(s)
  Keiko Yamamoto, Yuta Sakamaki, Yuka Inaba, Nobuko Yoshimoto, Toshimasa Itoh, Makoto Nakabayashi, Teikichi Ikura, Nobutoshi Ito
- Organizer
  8th AFMC International Medicinal Chemistry Symposium. Frontier of Medicinal Science
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PROJECT-23590135
[Presentation] 22-ブチルビタミンD誘導体の作用発現機構に関する構造生物学的研究2011
- Author(s)
  吉本暢子、酒巻雄太、稲葉有香、伊藤俊将、中林誠、伊藤暢聡、山本恵子
- Organizer
  日本薬学会第131年会
- Place of Presentation
  (要旨集上にて発表)
- Year and Date
  2011-03-05
- Data Source
  KAKENHI-PROJECT-20590108
[Presentation] 高度不飽和長鎖脂肪酸の簡便な合成法の確立2010
- Author(s)
  伊藤俊将,稲葉有香,山口拓也,山本恵子
- Organizer
  ビタミン学会第62回大会
- Place of Presentation
  盛岡
- Year and Date
  2010-06-11
- Data Source
  KAKENHI-PROJECT-20590108
[Presentation] ビタミンD受容体-リガンド結合領域と新規アゴニストの複合体のX線結晶構造解析2010
- Author(s)
  稲葉有香,伊藤俊将,酒巻雄太,吉本暢子,中林誠,伊倉貞吉,伊藤暢聡,清水正人,山本恵子
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-20590108
[Presentation] 五員環の複素環構造を基盤とした芳香族アミドの立体特性2010
- Author(s)
  山本紗をり
- Organizer
  第21回基礎有機化学討論会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19201044
[Presentation] 22-アルキルビタミンD誘導体の合成と生物活性評価2010
- Author(s)
  山本恵子,酒巻雄太,稲葉有香,吉本暢子
- Organizer
  ビタミン学会第62回大会
- Place of Presentation
  盛岡
- Year and Date
  2010-06-11
- Data Source
  KAKENHI-PROJECT-20590108
[Presentation] 酸化型脂肪酸とPPAR_YのX-線結晶構造解析2010
- Author(s)
  伊藤俊将、山本恵子
- Organizer
  第54回日本薬学会関東支部大会
- Place of Presentation
  八王子市・東京薬科大学
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-20590108
[Presentation] 22-アルキルビタミンD誘導体の合成と生物活性評価2010
- Author(s)
  山本恵子
- Organizer
  ビタミン学会第62回大会
- Place of Presentation
  盛岡市・いわて県民情報交流センター
- Year and Date
  2010-06-11
- Data Source
  KAKENHI-PROJECT-20590108
[Presentation] 1,24-Dihydroxyvitamin D3 Analogs with Branched 22-Butyl Group : Biological Activities and Interaction with the Vitamin D Receptor.2009
- Author(s)
  Keiko Yamamoto, Yuka Inaba, Makoto Nakabayashi, Toshimasa Itoh, Masato Shimizu, Teikichi Ikura, Nobutoshi Ito
- Organizer
  14th Workshop on Vitamin D.Brugge, Belgium.
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-20590108
[Presentation] 1α,24-DIHYDROXYVITAMIN D_3 ANALOGS WITH BRANCHED 22-BUTYL GROUP : BIOLOGICAL ACTIVITIES AND INTERACTION WITH THE VITAMIN D RECEPTOR2009
- Author(s)
  Keiko Yamamoto
- Organizer
  14th Workshop on Vitamin D
- Place of Presentation
  ベルギー(ブルージュ)
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-20590108
[Presentation] 22R-アルキル活性型ビタミンD誘導体の合成と生物活性評価
- Author(s)
  穴見康昭、酒巻雄太、加藤晃、吉本暢子、伊藤俊将、山本恵子
- Organizer
  第23回日本レチノイド研究会学術集会
- Place of Presentation
  鳥取（米子コンベンションセンター）
- Data Source
  KAKENHI-PROJECT-23590135
[Presentation] 22R-アルキルビタミンD誘導体/受容体複合体のＸ線結晶構造解析
- Author(s)
  穴見康昭、吉本暢子、伊藤俊将、山本恵子
- Organizer
  日本ケミカルバイオロジー学会第8回年会
- Place of Presentation
  東京医科歯科大学（東京都、文京区）
- Data Source
  KAKENHI-PROJECT-23590135
[Presentation] 結晶構造に基づくビタミンD受容体パーシャルアゴニスト作用の分子基盤研究
- Author(s)
  穴見康昭、伊藤俊将、山本恵子
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学（熊本県、熊本市）
- Data Source
  KAKENHI-PROJECT-23590135
[Presentation] ビタミンＤと関連タンパク質（CYP, VDR, DBP）の構造生命科学
- Author(s)
  山本恵子
- Organizer
  日本ビタミン学会第６５回大会
- Place of Presentation
  一橋講堂（東京都、千代田区）
- Invited
- Data Source
  KAKENHI-PROJECT-23590135
[Presentation] ビタミンD受容体の活性コンフォメーション形成を阻止するスーパーアンタゴニストの創製研究
- Author(s)
  加藤晃、吉本暢子、伊藤俊将、山本恵子
- Organizer
  第24回日本レチノイド研究会学術集会
- Place of Presentation
  星薬科大学（東京都、品川区）
- Data Source
  KAKENHI-PROJECT-23590135
[Presentation] Synthesis and Characterization of Active Vitamin D Analogues with 22R-alkyl Group
- Author(s)
  Yasuaki Anami, Nobuko Yoshimoto, Toshimasa Itoh, Keiko Yamamoto
- Organizer
  14th Tetrahedron Symposium
- Place of Presentation
  Hilton Vienna (Vienna, Austria)
- Data Source
  KAKENHI-PROJECT-23590135
[Presentation] ビタミンD受容体の活性型コンフォメーションを阻止するリガンドの設計、合成と生物活性
- Author(s)
  加藤晃、吉本暢子、穴見康昭、江川大地、伊藤俊将、山本恵子
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜（パシフィコ横浜）
- Data Source
  KAKENHI-PROJECT-23590135

1. YMADA Sachiko (10014078)

# of Collaborated Projects : 10results

# of Collaborated Products : 1results
2. SHIMIZU Masato (50126231)

# of Collaborated Projects : 8results

# of Collaborated Products : 0results
3. KAGECHIKA Hiroyuki (20177348)

# of Collaborated Projects : 1results

# of Collaborated Products : 4results
4. HIRANO Tomoya (20396980)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
5. SHUDO Koichi (50012612)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
6. YOSHIDA Yuki (00297045)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
7. ITOH Toshimasa (80536110)

# of Collaborated Projects : 1results

# of Collaborated Products : 8results
8. KOYAMA Takatoshi (20234916)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
9. DELUCA Hecto

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. DELUCA H.F.

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. REISCHL Wolfgang

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

Yamamoto Keiko 山本 恵子

YAMAMOTO Keiko 山本 恵子

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ビタミンD受容体コファクターペプチドの網羅的合成と機能解析Principal InvestigatorOngoing

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Development of reversible covalent vitamin D receptor ligandsPrincipal Investigator

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Discovery of ligands that modulate the pocket structure of vitamin D receptorPrincipal Investigator

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Role of ligands for allosteric network of nuclear receptorsPrincipal Investigator

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Development of antidiabetic agents targeting PPARγPrincipal Investigator

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Studies on response element of vitamin D target genes and discrimination of vitamin D actionsPrincipal Investigator

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Conformational Analysis of Vitamin D Resposible for Binding to VDR and DBPPrincipal Investigator

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Yamamoto Keiko 山本恵子

YAMAMOTO Keiko 山本恵子