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HOSOI Kazuo  細井 和雄

Researcher Number 10049413
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-5165-5056
External Links
Affiliation (based on the past Project Information) *help 2013: 徳島大学, 大学院ヘルスバイオサイエンス 研究部(歯学系), 教授
2011 – 2013: 徳島大学, ヘルスバイオサイエンス研究部, 教授
2010 – 2011: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授
2008: 徳島大学, 大学院・ヘルスバイオサイエンス, 教授
2008: The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 教授 … More
2007: The University of Tokushima, 大学院・ヘルスバイ拶イエンス研究部, 助教
2005 – 2006: 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授
2004: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授
1999 – 2003: 徳島大学, 歯学部, 教授
1996 – 1997: 徳島大学, 歯学部, 教授
1994: University of Tokushima, School of Dentistry, Department of Physiology, Professor, 歯学部, 教授
1992 – 1993: 明海大学, 歯学部, 助教授
1988 – 1989: 明海大学, 歯学部, 助教授
1987: 城西歯科大学, 歯学部, 助教授 Less
Review Section/Research Field
Principal Investigator
Functional basic dentistry / Functional basic dentistry
Except Principal Investigator
Functional basic dentistry / Functional basic dentistry / Morphological basic dentistry
Keywords
Principal Investigator
唾液腺 / LPS / トラフィッキング / アクアポリン / Brunner's gland / duodenum / salivary gland / trafficking / aquaporins / ブルナー腺 … More / 十二指腸 / Calcium influx / Intracellular calcium / Inositol metabolism / Protein phosphosphorylation / EGF Receptors / P_2 Purinoceptors / 細胞内Ca^<2+> / カルシウムインフラックス / 細胞内カルシウム / 蛋白質りん酸化 / EGF受容体 / P_2プリン受容体 / 炎症性サイトカイン / りん酸化 / ホスファチジールイノシトールりん酸代謝 / 燐酸化 / ホスファチジールイノシトール燐酸代謝 / Ca^<2+>輸送 / プリン受容体 / 細胞外ATP / イノシト-ル代謝 / genetic variation / Sprague-Dawley rat / 遺伝的変動 / SDラット / VIP / Salivary gland / exocrine gland / Inflammation cytokine / Acute phase protein / Kininogen / 外分泌腺 / 急性期蛋白質 / キニノーゲン / gastrointestinal tract / 細胞内カルシウムイオン / 細胞骨格 / 消化管 / Processing enzyme / Mouse / Submandibular gland / True tissue kallikrein / Proreninn converting enzyme / Tissue kallikrein family / 成長因子 / プロセッシング / プロレニン / 組織カリクレイン / プロセシング酵素 / マウス / 真性組織カリクレイン / プロレニン変換酵素 / 組織カリクレインファミリー / ホスファチジルイノシトールりん酸 / イノシトール代謝 / 鼓索神経切除 / 遺伝子変異 / アクアポリン5 / GFP-AQP5キメラ分子 / MDCK細胞 / 塩酸セビメリン / 副交感神経 / カテプシン / 幹細胞特異抗原 / カリクレインmK13 / IL-1β / TLR4 … More
Except Principal Investigator
STR / 顎下腺 / aquaporin 1 / submandibular gland / fetal / aquaporin 5 / N mice / kidney / polydipsia / aquaporin2 / プロテインキナーゼA / 外分泌腺 / トラフィッキング / アクアポリン / アクアポリン1 / 胎児 / アクアポリン5 / Nマウス / 腎臓 / 多渇多飲症 / アクアポリン2 / HSG細胞 / bHLH型転写因子 / AQP5 / 水チャネル / PACE4 / サチライシン様前駆体蛋白質変換酵素 / 発生・分化・再生 / 腺房細胞 / 電子顕微鏡 / Androgen / マウス / 表現型 / 免疫組織化学 / ホルモン受容体 / 甲状腺ホルモン / アンドロゲン / 顆粒性導管 / 唾液腺 Less
  • Research Projects

    (12 results)
  • Research Products

    (34 results)
  • Co-Researchers

    (19 People)
  •  病態時における外分泌腺型水チャネル、AQP5の発現と機能調節の分子機構Principal Investigator

    • Principal Investigator
      細井 和雄
    • Project Period (FY)
      2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      The University of Tokushima
  •  Elucidation of the molecular mechanism on the differentiation/maturation and functional expression of salivary acinar cell toward conquest of xerostomia.

    • Principal Investigator
      AKAMATSU Tetsuya
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      The University of Tokushima
  •  Immunolocalization of hormone receptors and their regulatory system in the hormonally responsive ducts of the mouse salivary glands

    • Principal Investigator
      KURABUCHI Shingo
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      The Nippon Dental University
  •  Moecular meohanism of expression and regulation of the water channe1, aquapor in 5 in the exocrine glandPrincipal Investigator

    • Principal Investigator
      HOSOI Kazuo
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      The University of Tokushima
  •  唾液腺における炎症性サイトカインの誘導と口腔の防御システム:再生医療への試みPrincipal Investigator

    • Principal Investigator
      細井 和雄
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Functional basic dentistry
    • Research Institution
      The University of Tokushima
  •  Inflammation by mast cell kininogen and its suppression -Development of a new drugPrincipal Investigator

    • Principal Investigator
      HOSOI Kazuo
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      The University of Tokushima
  •  Molecular mechanisms of expression and regulation of water channel proteins aquaporins in the exocrine gland cellsPrincipal Investigator

    • Principal Investigator
      HOSOI Kazuo
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      The University of Tokushima
  •  Molecular mechanisms of expression and regulation of water channel proteins aquaporins in the exocrine gland cells

    • Principal Investigator
      HOSOI Keiko
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Tokushima University
  •  Molecular mechanisms of expression and regulation of function of water channel proteins aquaporins in the salivary gland cellsPrincipal Investigator

    • Principal Investigator
      KAZUO Hosoi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      University of Tokushima
  •  A new physiologic function of tissue kallikrein family enzymes and processing of growth factor precursorsPrincipal Investigator

    • Principal Investigator
      HOSOI Kazuo
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      THE UNIVERSITY OF TOKUSHIMA,SCHOOL OF DENTISTRY
  •  Regulation of the function of EGF receptors via P_2 purinergic receptors and related cell signaling systemsPrincipal Investigator

    • Principal Investigator
      HOSOI Kazuo
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      UNIVERSITY OF TOKUSHIMA SCHOOL OF DENTISTRY
      Meikai University
  •  Effects of extracellular ATP on Ca^<2+> movement, and phosphoinositide metabolism, leading to a functional change of EGF receptorPrincipal Investigator

    • Principal Investigator
      HOSOI Kazuo
    • Project Period (FY)
      1987 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Meikai University

All 2014 2011 2009 2008 2007 2006 2005 2004

All Journal Article Presentation Book

  • [Book] 動物細胞培養の手法と細胞死・増殖不良・細胞変異を防止する技術(第8節[14]唾液腺研究における組織培養・分化誘導系)2014

    • Author(s)
      赤松徹也,姚陳娟,細井和雄
    • Publisher
      ㈱技術情報協会
    • Data Source
      KAKENHI-PROJECT-23592737
  • [Book] 動物細胞培養の手法と細胞死・増殖不良・細胞変異を防止する技術(第9章12節唾液腺研究における組織培養・分化誘導系)2014

    • Author(s)
      赤松徹也,姚陳娟,細井和雄
    • Publisher
      ㈱技術情報協会
    • Data Source
      KAKENHI-PROJECT-23592737
  • [Book] 基礎歯科生理学(森本俊文、山田好秋編)第5版2008

    • Author(s)
      細井和雄他(分担執筆)
    • Total Pages
      466
    • Publisher
      医歯薬出版
    • Data Source
      KAKENHI-PROJECT-18390493
  • [Book] 基礎歯科生理学(森本俊文、山田好秋編)第5版2008

    • Author(s)
      細井 和雄, 他(分担執筆)
    • Publisher
      医歯薬出版
    • Data Source
      KAKENHI-PROJECT-18390493
  • [Book] なるほど現代歯塾(徳島大学編)2007

    • Author(s)
      細井和雄 他
    • Total Pages
      136
    • Publisher
      医歯薬出版(東京)
    • Data Source
      KAKENHI-PROJECT-18390493
  • [Book] 医歯薬出版(東京)(徳島大学編)2007

    • Author(s)
      細井和雄他(分担執筆)
    • Total Pages
      136
    • Publisher
      なるほど現代歯塾
    • Data Source
      KAKENHI-PROJECT-18390493
  • [Book] 口腔生物学-各論 唾液腺(天野 修, 草間 薫編集)2006

    • Author(s)
      細井和雄 他
    • Total Pages
      144
    • Publisher
      学建書院(東京)
    • Data Source
      KAKENHI-PROJECT-18390493
  • [Book] 口腔生物学-各論 唾液腺(天野 修、草間 薫編集)2006

    • Author(s)
      細井和雄, 赤松徹也, 他(分担執筆)
    • Total Pages
      144
    • Publisher
      学建書院
    • Data Source
      KAKENHI-PROJECT-16659513
  • [Book] 口腔生物学-各論唾液腺(天野修、草間薫編集)2006

    • Author(s)
      細井和雄, 赤松徹也, 他(分担執筆)
    • Total Pages
      144
    • Publisher
      学建書院(東京)
    • Data Source
      KAKENHI-PROJECT-18390493
  • [Book] 口腔生物学各論-唾液腺-(天野 修、草間 薫 編集)2005

    • Author(s)
      細井和雄 他
    • Publisher
      学建書院(印刷中)
    • Data Source
      KAKENHI-PROJECT-16659513
  • [Book] 分子細胞生物学基礎実験法 改訂第2版(堀尾武一監修,新垣尚捷,角野富三郎,西川克三,樋口富彦,細井和雄,堀内義史,松尾雄志,宮崎 香 編集)2004

    • Author(s)
      細井和雄 他(分担執筆)
    • Total Pages
      654
    • Publisher
      南江堂
    • Data Source
      KAKENHI-PROJECT-16659513
  • [Book] Handbook of proteolytic enzymes, 2nd edition(Edited by Barrett A.J., Rawlings N.D., Woessner, Jr., J.F.)2004

    • Author(s)
      Hosoi, K. et al.
    • Total Pages
      2368
    • Publisher
      Elsevier (Academic press imprint)
    • Data Source
      KAKENHI-PROJECT-16659513
  • [Journal Article] アクアポリン5自然発生遺伝子変異の水チャネル機能に及ぼす影響2011

    • Author(s)
      Hosoi K
    • Journal Title

      四国歯学会雑誌

      Volume: 24(2) Pages: 51-57

    • Data Source
      KAKENHI-PROJECT-23592736
  • [Journal Article] MINI-REVIEW Hormone-induced granular convoluted tubule-like cells in mouse parotid gland2009

    • Author(s)
      Kurabuchi S, Matsuoka T, Hosoi K
    • Journal Title

      The Journal of Medical Investigation 56 (Suppl)

      Pages: 290-295

    • Data Source
      KAKENHI-PROJECT-20592158
  • [Journal Article] Immunocytochemical study of granular duct cells with a hormonally enhanced granular cell pheno-type in the mouse parotid gland.2009

    • Author(s)
      Kurabuchi S, Hosoi K
    • Journal Title

      Odontology 97

      Pages: 57-61

    • Data Source
      KAKENHI-PROJECT-20592158
  • [Journal Article] Immunocytochemical study of granular duct cells with a hormonally enhanced granular cell phenotype in the mouse parotid gland2009

    • Author(s)
      Kurabuchi S & Hosoi K
    • Journal Title

      Odontology 97

      Pages: 57-61

    • NAID

      10027301376

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592158
  • [Journal Article] Trafficking of GFP-AQP5 chimeric proteins conferred with unphosphorylated amino acids at their PKA-target motif(152SRRTS) in MDCK-II cells2009

    • Author(s)
      Karabasil, M.R., T. Hasegawa, A. Azlina, N. Purwanti, J.Purevjav, C. Yao, T. Akamatsu and K. Hosoi
    • Journal Title

      The Journal of Medical Investigation 56(1, 2)

      Pages: 55-63

    • NAID

      130004465167

    • Data Source
      KAKENHI-PROJECT-18390493
  • [Journal Article] MINI-REVIEW : Hormone-induced granular convoluted tubule-like cells in mouse parotid gland.2009

    • Author(s)
      Kurabuchi S, Matsuoka T, Hosoi K
    • Journal Title

      J Medical Investigation 56

      Pages: 290-295

    • Data Source
      KAKENHI-PROJECT-20592158
  • [Journal Article] Immunocytochemical study of granular duct cells with a hormonally enhanced granular cell phenotype in the mouse parotid gland2009

    • Author(s)
      Kurabuchi S, Hosoi K
    • Journal Title

      Odontology 97

      Pages: 57-61

    • NAID

      10027301376

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592158
  • [Journal Article] Inhibition and transcriptional silencing of a subtilisin-like proprotein convertase, PACE4/SPC4, reduces the branching morphogenesis of and AQP5 expression in rat embryonic submandibular gland2009

    • Author(s)
      Akamatsu, T., A. Azlina, N. Purwanti, M.R. Karabasil, T. Hasegawa, C. Yao, and K. Hosoi
    • Journal Title

      Developmental Biology 325(2)

      Pages: 434-443

    • Data Source
      KAKENHI-PROJECT-18390493
  • [Journal Article] Degradation of submandibular gland AQP5 by parasympathetic denervation of chords tympani and its recovery by cevimeline, an M3 muscarinic receptor agonist2008

    • Author(s)
      Li X., A. Azlina, M.R. Karabasil, N. Purwanti, T. Hasegawa, C. Yao, T. Akamatsu, and K. Hosoi
    • Journal Title

      American Journal of Physiology-Gastrointestinal and Liver Physiology 295(1)

      Pages: 112-123

    • Data Source
      KAKENHI-PROJECT-18390493
  • [Journal Article] Hypophysectomy and hormonal therapy modulate mK1-immuno-reactive duct cells in the mice sublingual glands2008

    • Author(s)
      Kurabuchi S, Gresik EW, Chenjuan Yao & Hosoi K
    • Journal Title

      Journal Molecular Histology 39

      Pages: 499-507

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592158
  • [Journal Article] Hypophysectomy and hormonal therapy modulate mK1-immunoreactive duct cells in the mice sublingual glands.2008

    • Author(s)
      Kurabuchi S, Gresik EW, Yao C, Hosoi K
    • Journal Title

      J Molecular Histology 39

      Pages: 499-507

    • Data Source
      KAKENHI-PROJECT-20592158
  • [Journal Article] Temporospatially regulated expression of subtilisin-like proproteinconvertase PACE4 (SPC4) during development of the rat submandibular gland2007

    • Author(s)
      Akamatsu, T., N. Purwanti, M.R. Karabasil, X. Li, C. Yao, N. Kanamori, and K.Hosoi
    • Journal Title

      Developmental Dynamics 236(1)

      Pages: 314-320

    • Data Source
      KAKENHI-PROJECT-18390493
  • [Journal Article] Protein kinase A-regulated membrane trafficking of a green fluorescent protein-aquaporin 5 chimera in MDCK cells2006

    • Author(s)
      Kosugi-Tanaka, C., X. Li, C. Yao, T. Akamatsu, N. Kanamori, and K. Hosoi
    • Journal Title

      Biochimica et Biophysica Acta, Molecular Cell Research 1763(4)

      Pages: 337-344

    • Data Source
      KAKENHI-PROJECT-18390493
  • [Journal Article] AQP and the control of fluid transport in a salivary gland2006

    • Author(s)
      Murakami, M., K. Murdiastuti, K. Hosoi, and A.E. Hil
    • Journal Title

      Journal of Membrane Biology 210(2)

      Pages: 91-103

    • Data Source
      KAKENHI-PROJECT-18390493
  • [Journal Article] A naturally occurring point mutation in the rat aquaporin 5 gene, influencing its protein production by and secretion of water from salivary glands2006

    • Author(s)
      Murdiastuti, K., N. Purwanti, M.R. Karabasil, X. Li, C. Yao, T. Akamatsu, N. Kanamori, and K. Hosoi
    • Journal Title

      American Journal of Physiology-Gastrointestinal and Liver Physiology 291(6)

      Pages: 1081-1088

    • Data Source
      KAKENHI-PROJECT-18390493
  • [Journal Article] Acute phase protein induction by experimental inflammation in the salivary gland2005

    • Author(s)
      Yao, C., W.Wei, X.Li, K.Hosoi
    • Journal Title

      Journal of Oral Pathology and, Medicine (in press)

    • Data Source
      KAKENHI-PROJECT-16659513
  • [Journal Article] Subcellular redistribution of AQP5 by vasoactive intestinal polypeptide (VIP) in the Brunner's gland of the rat duodenum2005

    • Author(s)
      Parvin, M.N., S.Kurabuchi, K.Murdiastuti, C.Yao, C.Kosugi-Tanaka, T.Akamatu, N.Kanamori, K.Hosoi
    • Journal Title

      American Journal of Physiology-GI and Liver Physiology (in press)

    • Data Source
      KAKENHI-PROJECT-16659513
  • [Journal Article] Difference in substrate and inhibitor sequence specificity of human, mouse and rat tissue kallikreins2004

    • Author(s)
      Fogaca, S.E., R.L.Melo, D.C.Pimenta, K.Hosoi, L.Juliano, M.A.Juliano
    • Journal Title

      Biochemical Journal 380(Pt3)

      Pages: 775-781

    • Data Source
      KAKENHI-PROJECT-16659513
  • [Journal Article] Immunocytochemical localization of mK1, a true tissue kallikrein, in the mouse parotid gland : sexual dimorphism and effects of castration and hypophysectomy2004

    • Author(s)
      Kurabuchi, S., K.Hosoi
    • Journal Title

      Odontology 92(1)

      Pages: 73-76

    • NAID

      10014199071

    • Data Source
      KAKENHI-PROJECT-16659513
  • [Journal Article] Additive and/or synergistic action (downregulation) of androgens and thyroid hormones on the cellular distribution and localization of a true tissue kallikrein, mK1, in the mouse submandibular gland2004

    • Author(s)
      Kurabuchi, S., E.W.Gresik, K.Hosoi
    • Journal Title

      Journal of Histochemistry and Cytochemistry 52(11)

      Pages: 1437-1446

    • Data Source
      KAKENHI-PROJECT-16659513
  • [Presentation] Characterization of hormone-responsible GCT-like cells in the parotid gland of mice2009

    • Author(s)
      Kurabuchi S, Hosoi K
    • Organizer
      The 11^<th> International Symposium on Exocrine Secretion "Exocrine Secretion-Mechanism and Disease"
    • Place of Presentation
      Tokushima, Japan
    • Data Source
      KAKENHI-PROJECT-20592158
  • [Presentation] Characterization of hormone-responsible GCT-like cells in the parotid gland of mice.2009

    • Author(s)
      Kurabuchi S, Hosoi K
    • Organizer
      The 11^<th> International Symposium on Exocrine Secretion "Exocrine Secretion-Mechanism and Disease"
    • Place of Presentation
      Tokushima
    • Data Source
      KAKENHI-PROJECT-20592158
  • 1.  AKAMATSU Tetsuya (80294700)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 10 results
  • 2.  KANAMORI Norio (90064865)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 4 results
  • 3.  TADA Jun (00314865)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  TSUMURA Keiko (50127841)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  HASEGAWA Takahiro (50447273)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 3 results
  • 6.  YAO Chenjuan (20432750)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 7.  SUGITA Kenji (90171157)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  KURIHARA Kinji (10170086)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  KURABUCHI Shingo (90170076)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 10.  MATSUMOTO Takuya (90284299)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  KIKKAWA Yamato (20274227)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  MATSUURA Sachiko (50139854)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  HANEJI Tatsuji (50156379)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  NAKAJO Nobuyoshi (80069046)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  李 雪飛
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  NUNUK Purwanti
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  MILEVA Ratko Karabasil
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  AZLINA Ahmad
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 19.  JAVKHLAN Purevjav
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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