TAKAHASHI Kazuhiko 高橋和彦

… Alternative Names

高橋和彦タカハシカズヒコ

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Researcher Number	10113581
Other IDs
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Affiliation (based on the past Project Information) *help	2016: 北海道薬科大学, 基礎教育系, 教授 2005: 北海道薬科大学, 薬学部, 教授 2004: 北海道大学, 大学院・薬学研究科, 助教授 2001: 北海道大学, 薬学研究科, 助教授 1998 – 2000: 北海道大学, 大学院・薬学研究科, 助教授 … More 1998: 北海道大学, 大学院薬学研究科, 助教授 1992 – 1997: 北海道大学, 薬学部, 助教授 1987 – 1990: 北海道大学, 薬学部, 助手 1988: 北海道大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Structural biochemistry / Functional biochemistry / Environmental pharmacy / 物質生物化学 Except Principal Investigator Biological pharmacy / Food science / 物質生物化学 / Cerebral neurosurgery
Keywords	Principal Investigator セレン / グルタチオンペルオキシダーゼ / 必須微量元素 / 翻訳 / RNA結合因子 / セレノプロテインP / トランスポーター / 細胞増殖 / セレノシステイン / アポトーシス … More / 活性酸素 / CR3 / 補体レセプタ- / ス-パ-オキシド / 多形核白血球 / FcR / レセプタ- / 抗体 / 食細胞 … More Except Principal Investigator 補体 / 免疫 / アポトーシス / 食細胞 / NADPHオキシダーゼ / EF-1α / complement / tumor cells / M.fermentans / マクロファージ / APOPTOSIS / COMPLEMENT / 補体レセプター / Fcレセプター / 生体防御 / Phagocytosis / Phospholipase A_2 / NADPH oxidase / Fc receptor / Antibody / Macrophage / 食作用 / 抗体 / 多形核白血球 / セレン / 急性相蛋白質 / 外因系凝固 / 補体系 / クロスリンカー / セレン運搬作用 / セレノプロテインP / 酸化ストレス / 回収エンドソーム / リソソーム / 細胞内輸送 / 糖尿病 / 栄養生化学 / セレノプロテイン / 中和抗体 / インスリン / 膵β細胞 / 受容体 / トランスポーター / Superoxide Anion / Cytochrome b_<558> / Leukocyte / NADPH-Cytochrome c Reductase / NADPH Oxidase / Chronic Granulomatous Disease / チトクロームb_<558> / NADPHーチトクロームCレダクターゼ / チトクロ-ムb_<55g> / ス-パ-オキシドアニオン / チトクロ-ム b^<558> / 白血球 / NADPH-チトクロ-ムCレダクタ-ゼ / NADPH オキシダ-ゼ / 慢性肉芽腫症 / Protease / Plasma Protein / Inter- trypsin Inhibitor / プロテアーゼ阻害物質 / トリプシン / 阻害因子 / プロテアーゼ / 血漿蛋白質 / インターαトリプシンインヒビター / Polymorphonuclear leukocyte / スーパーオキシド / ミクロフィラメント / ホスホリパーゼA_2 / apoptosis / phagocytosis / neutrophils / sulfatides / スフィンゴ脂質 / セレブロシド / MCP / 麻疹ウイルス / スルファチド / M. fermentans / cytotoxicity / natural killer cells (NK) / Innate immunity / オプソニン効果 / M161抗原 / MHCクラスI / NK細胞 / 細胞傷害作用 / 癌細胞 / ナチュラルキラー細胞(NK) / 先天性免疫 / MACROPHAGE / IMMUNOLOGY / OPSONIN / PHAGOCYTOSIS / ガン細胞 / アポトシス / オプソニン / RECEPTORS / POSONIZATION / IMMUNE RESPONSE / PHAGOCYTES / 活性酸素 / 抗体レセプター / 免疫応答 / Receptor / Endothelial cells / Host defense / Anaphylatoxin / Immunology / Complement / レセプター / 血管内皮細胞 / アナフィラトキシン / Phosphatidylinositol / Polymorphonuclear lukocyte / F_Cレセプタ- / 多形核白亜球 / イノシト-ルリン脂質 / ホスホリパ-ゼA_2 / NADPHオキシダ-ゼ / Fcレセプタ- / マクロファ-ジ / インターロイキン-6(IL-6) / プロテインS / C4b結合蛋白質(C4bp) / チオレドキシン還元酵素 / 細胞増殖 / immediate early gene / 熱ショック蛋白 / 脳血管内皮細胞 / 頭部外傷 / 脳虚血 / フリーラジカル / トランスジェニックマウス / スーパーオキサイド / プロティンS / C4b結合性蛋白質 Less

Selenium-transport mechanism of selenoprotein P
- Principal Investigator
  
  Saito Yoshiro
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Food science
- Research Institution
  Doshisha University
必須微量元素セレン・トランスポーター受容体の同定と取り込み機構の解析Principal Investigator
- Principal Investigator
  
  高橋和彦
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Environmental pharmacy
- Research Institution
  Hokkaido Pharmaceutical University School of Pharmacy
  Hokkaido University
必須微量元素セレンを運搬する蛋白質の同定と運搬機構の解析Principal Investigator
- Principal Investigator
  
  高橋和彦
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
Studies on effector molecules of innate immunity responsible for cytotoxicity to tumor cells.
- Principal Investigator
  
  NAGASAWA Shigeharu
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
新規,細胞増殖因子としてのセレン含有蛋白質の探索
- Principal Investigator
  
  長澤滋治
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
Studies on effector molecules of innate immunity responsible for cytotoxicity to tumor cells.
- Principal Investigator
  
  NAGASAWASHIGEHARU
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
21番目のアミノ酸の翻訳に関与する新規RNA結合因子の研究Principal Investigator
- Principal Investigator
  
  高橋和彦
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Hokkaido University
APOPTOSIS AND COMPLEMENT-STUDIES ON THE MECHANISM OF COMPKEMENT ACTIVATION AND THE BIOLOGICAL SIGNIFICANCE
- Principal Investigator
  
  NAGASAWA Shigeharu
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
HIV-I構成蛋白やセレン含有蛋白の翻訳に必須な新規RNA結合因子の探索Principal Investigator
- Principal Investigator
  
  高橋和彦
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Hokkaido University
ヒトSOD遺伝子導入マウスを用いた神経損傷におけるSOD保護効果の研究
- Principal Investigator
  
  吉本高志
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Tohoku University
細胞の生存維持・増殖に必須なセレン含有因子の探索Principal Investigator
- Principal Investigator
  
  高橋和彦
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
STUDIES ON THE BIOLOGICAL FUNCTIONS OF THE COMPLEMENT SYSTEM
- Principal Investigator
  
  NAGASAWA Shigeharu
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
Studies on molecular constitution and effector functions of complement system
- Principal Investigator
  
  NAGASAWA Shigeharu
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
ヒト食細胞の抗体レセプタ-の構造と機能に関する生化学的研究Principal Investigator
- Principal Investigator
  
  高橋和彦
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  物質生物化学
- Research Institution
  Hokkaido University
補体系による外因系血液凝固の活性化と制御に関する研究
- Principal Investigator
  
  NAGASAWA Shigeharu
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
Studies on the Molecular Mechanisms of Regulation of Activation of Various Functions in Phagocytes
- Principal Investigator
  
  KOYAMA Jiro
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University, Faculty of Pharmaceutical Sciences
補体系による外因系血液凝固の活性化と制御に関する研究
- Principal Investigator
  
  長沢滋治
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
Analysis of the molecular pathology of chronic granulomatous disease by assay of the components of the NADPH oxidase
- Principal Investigator
  
  KOYAMA Jiro
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
Studies on the molecular mechanisms by which phagocytes recognize and eliminate antigens
- Principal Investigator
  
  KOYAMA Jiro
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University,
Biochemical Studies on Human Inter- trypsin Inhibitor
- Principal Investigator
  
  NAGASAWA Shigeharu
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  物質生物化学
- Research Institution
  Hokkaido University

All 2016 2015 2014 2013

All Journal Article Presentation

[Journal Article] Development of a Sol Particle Homogeneous Immunoassay for Measuring Full-Length Selenoprotein P in Human Serum.2016
- Author(s)
  M. Tanaka, Y. Saito, H. Misu, S. Kato, Y. Kita, Y. Takeshita, T. Kanamori, T. Nagano, M. Nakagen, T. Urabe, T. Takamura, S. Kaneko, K. Takahashi and N. Matsuyama.
- Journal Title
  
  J Clin Lab Anal
  
  Volume: 30 Issue: 2 Pages: 114-122
- DOI
  10.1002/jcla.21824
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461334, KAKENHI-PROJECT-25292078, KAKENHI-PROJECT-26461329, KAKENHI-PROJECT-16K09740
[Journal Article] The protective role of DJ-1 in ultraviolet-induced damage of human skin: DJ-1 levels in the stratum corneum as an indicator of antioxidative defense.2015
- Author(s)
  Shioji Ishiwatari, Minako Takahashi, Chie Yasuda, Maho Nakagawa, Tatsuya Kon, Yoshiro Saito, Noriko Noguchi, and Shoko Matsukuma
- Journal Title
  
  Archives of Dermatological Research
  
  Volume: 307 Issue: 10 Pages: 925-935
- DOI
  10.1007/s00403-015-1605-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25670084, KAKENHI-PROJECT-25292078
[Journal Article] Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells.2014
- Author(s)
  Ishikura K, Misu H, Kumazaki M, Takayama H, Matsuzawa-Nagata N, Tajima N, Chikamoto K, Lan F, Ando H, Ota T, Sakurai M, Takeshita Y, Kato K, Fujimura A, Miyamoto K, Saito Y, Kameo S, Okamoto Y, Takuwa Y, Takahashi K, Kidoya H, Takakura N, Kaneko S, Takamura T
- Journal Title
  
  Diabetologia
  
  Volume: 57 Issue: 9 Pages: 1968-1976
- DOI
  10.1007/s00125-014-3306-9
- NAID
  120005463349
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22112005, KAKENHI-PROJECT-24390051, KAKENHI-PUBLICLY-25116711, KAKENHI-PUBLICLY-25122710, KAKENHI-PROJECT-25282017, KAKENHI-PROJECT-25292078, KAKENHI-PROJECT-25461334, KAKENHI-PROJECT-25670162, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-26461329
[Presentation] セレノプロテインPの阻害抗体による糖尿病治療効果の解析―インスリン抵抗性および分泌能を改善する抗体医薬の開発2016
- Author(s)
  三田雄一郎、中山華穂、稲荷尚吾、西藤有希奈、吉岡佑弥、曽谷奏、高部稚子、御簾博文、篁俊成、高橋和彦、野口範子、斎藤芳郎
- Organizer
  日本糖尿病学会
- Place of Presentation
  国立京都国際会館（京都）
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] 75Seおよび免疫学的手法を用いたセレノプロテインＰのセレン運搬機構の解析2013
- Author(s)
  吉岡佑弥、西藤有希奈、三田雄一郎、高橋和彦、野口範子、斎藤芳郎
- Organizer
  第86回日本生化学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25292078
[Presentation] Study of selenium supply mechanism of selenoprotein P using 75Se and immunological methods2013
- Author(s)
  Yoshiro Saito, Yuuya Yoshioka, Yuichiro Mita, Kaho Nakayama, Yukina Nishito, Kazuhiko Takahashi, Noriko Noguchi
- Organizer
  10th International Symposium on Selenium in Biology and Medicine
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-25292078

1. NAGASAWA Shigeharu (70029958)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
2. YAMASHITA Toshiyuki (90192400)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
3. NISHIMURA Hitoshi (80241347)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. KOYAMA Jiro (10025679)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. MURAKAMI Yusuke (10250466)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. SEYA Tsukasa (10301805)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. ARIGA Hiroyoshi (20143505)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SATO Noriyuki (50158937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MATSUMOTO Shuzo (80000933)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Saito Yoshiro (70357060)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. NOGUCHI Noriko (40198578)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
12. 吉本高志 (50091765)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 加藤一郎 (50250741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 木内博之 (30241623)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 富永悌二 (00217548)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 中村亨 (30001978)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 高倉伸幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 御簾博文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKAHASHI Kazuhiko 高橋 和彦

高橋 和彦 タカハシ カズヒコ

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必須微量元素セレン・トランスポーター受容体の同定と取り込み機構の解析Principal Investigator

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必須微量元素セレンを運搬する蛋白質の同定と運搬機構の解析Principal Investigator

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21番目のアミノ酸の翻訳に関与する新規RNA結合因子の研究Principal Investigator

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HIV-I構成蛋白やセレン含有蛋白の翻訳に必須な新規RNA結合因子の探索Principal Investigator

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細胞の生存維持・増殖に必須なセレン含有因子の探索Principal Investigator

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ヒト食細胞の抗体レセプタ-の構造と機能に関する生化学的研究Principal Investigator

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TAKAHASHI Kazuhiko 高橋和彦

高橋和彦タカハシカズヒコ