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SEISHIMA Mitsuru  清島 満

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Researcher Number 10171315
Other IDs
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Affiliation (based on the past Project Information) *help 2015 – 2019: 岐阜大学, 大学院医学系研究科, 教授
2012 – 2015: 岐阜大学, 医学(系)研究科(研究院), 教授
2013: 岐阜大学, 医学系研究科, 教授
2012: 岐阜大学, 医学系研究科, 医学系研究科
2011: 岐阜大学, 医学研究科, 教授 … More
2010 – 2011: 岐阜大学, 医学系研究科, 教授
2009: Gifu University, 大学院・医学系研究科, 教授
2008: 岐阜大学, 医学研究科, 教授
2007: Gifu University, Graduate School of Medicine, Professor
2006: 岐阜大学, 大学院医学系研究科, 教授
2005: GIFU UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, PROFESSOR, 大学院・医学系研究科, 教授
2004: 岐阜大学, 大学院・医学研究科, 教授
1997 – 2003: Gifu University, School of Medicine, Professor, 医学部, 教授
1996: Div.Central Lab.Gifu Univ.School.Med.Assis.Prof., 医学部・附属病院, 講師
1995 – 1996: 岐阜大学, 医学部附属病院, 講師
1993 – 1994: 岐阜大学, 医学部, 講師
1991 – 1993: 岐阜大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Laboratory medicine / Laboratory medicine / Gastroenterology
Except Principal Investigator
Laboratory medicine / 食品科学・栄養科学 / Orthopaedic surgery / Laboratory medicine / Gastroenterology / Circulatory organs internal medicine / Eating habits / Neurochemistry/Neuropharmacology / Metabolomics / Gastroenterology
Keywords
Principal Investigator
Atherosclerosis / Knockout mouse / Bone marrow transplantation / Cytokine / Apo A-IV / アポA-IV / clinical test / biomarker / clinical proteome / プロテオーム … More / 質量分析 / 臨床検査 / バイオマーカー / 臨床プロテオーム / Apoptosis / Cytokines / pre βHDL / Corobary heart disease / Lipid-free-free apolipoprotein / preβ HDL / ELISA / Coronary heart disease / pre β HDL / Coronary heart desease / Lipid-free apolipoprotein / CaCo-2 cell / Fatty acids / CaCoー2cell / CaCo-2cell / 脂肪酸 / Hyperlipidemia / Polymorphism / 高脂血症 / 遺伝子多型性 / 細胞障害性T細胞 / 肝炎ウイルス / 急性肝炎 / 細胞傷害性T細胞 / インドールアミン酸素添加酵素 / B型肝炎ウイルス / CPTII遺伝子 / FACS / フローサイトメトリー / 遺伝子解析 / リアノジン受容体 / 細胞内カルシウム / 筋障害 / スタチン製剤 … More
Except Principal Investigator
TNF-α / サイトカイン / 動脈硬化 / HepG2 / コレステロール / ノックアウトマウス / Atherosclerosis / cholesterol / NF-kB / NF-κB / 胆汁酸 / AIDS / Macrophage / MCP-1 / VCAM-1 / ICAM-1 / マクロファージ / knockout mice / interleukin-1 / tumor necrosis factor-α / interferon-γ / encephalomyocarditis virus / genistein / apolipoprotein A-I / 大豆イソフラボン / ラット / Caco-2細胞 / ゲニステイン / アポリポタンパク質A-I / ポリフェノール / 慢性関節リウマチ / BRM / ELISA法 / ラテックス免疫比濁法 / 虚血性心疾患 / Lp(a)表現型 / インドールアミン酸素添加酵素 / TNF / ミセル / ソイスタチン / β-コングリシニン / 脂質ラフト / ペプチドアレイ / Caco-2 / 大豆β-コングリシニン / ラクトスタチン / アルカリフォスファターゼ / IIAEK / FP / ペプチド / 免疫学 / HSV-Tkマウス / 肝障害 / HSV-TKマウス / B型肝炎 / 動物モデル / HSV-TK / 抗HBV剤 / 宿主免疫応答 / 小動物疾患モデル / HBV / rhabdomvosis / statin drugs / hyperlipidemia / 横紋筋融解症 / スタチン系薬剤 / 高脂血症 / Proteome / TNFR-KO mouse / Inflammatory Bowel Disease / TNFRノックアウトマウス / 実験的大腸炎モデル / Trinitrobenzene suiphonic acid (TNBS) / 炎症性腸モデル / プロテオーム解析 / TNFR-KOマウス / 炎症性腸疾患 / Proteomics / macrophage / proteomics / プロテオミクス / chemokines / cell adhesion molecules / inflammatory cell infiltration / NE-κB / transgenic mice / reperfusion injury / ischemia / 好中球 / 再灌流障害 / 心筋虚血 / ケモカイン / 接着因子 / 炎症細胞浸潤 / トランスジェニックマウス / 再灌流傷害 / milk / bile acid / HMG-CoAreductase / CYP7A1 / mouse / β-lactoglobulin / コレステロール輸送担体 / 遺伝子 / 牛乳 / HMG-CoA還元酵素 / コレステロール7α-水酸化酵素 / マウス / β-ラクトグロブリン / inflammatory neurological disorders / NO synthase / indoleamine-2, 3-dioxygenase / dementia / トキソプラズマ / 脳神経疾患 / 炎症性脳神経疾患 / NO合成酵素 / indoleamine-2,3-dioxygenase / 痴呆 / estrogen receptor / estrogen / isoflavonoid / soybean / HDL / エストロゲン受容体 / エストロゲン / イソフラボン / アポリポプロテインA-I / 大豆 / Knockout Mice / Apolipoprotein E / アポリポ蛋白E / Cytokine / Soluble Fas / Apoptosis / Rheumatoid arthritis / 慢性関節リウマチ(RA) / Fas蛋白 / アポトーシス / cytokine / viral myocarditis / IL-1β / INF-α / IFN-γ / interleukin-6 / ウィルス心筋炎 / ウイルス心筋炎 / rat / chitosan / soy peptides / hesperetin / polyphenol / 遺伝子プロモーター / ワイン / カゼイン / リン脂質 / ラツト / キトサン / 大豆ペプチド / ヘスペレチン / immunotherapy / retrovirus / lymphocyte phenotypes / soluble interleukin-2 receptor / rheumatoid arthritis / レトロウイルス / 接着分子 / 可溶性L-selectin / インターロイキン2 / 遺伝子解析 / レトロウィルス / intra-arterial infusion chemotherapy / immunochemotherapy / anti-cancer agent / malignant bone tumor / 動注療法 / 免疫化学療法 / 抗癌剤 / 悪性骨腫瘍 / Restriction enzyme KpnI / Genotype / Phenotype / Apo(a) isoform / LIA / TIA / ELISA / Apolipoprotein(a) / コンピュータ処理 / 自動化 / 遺伝型 / 表現型 / パーソナルコンピューター / 自動分析装置 / ラテックス免疫凝集比濁法 / 免疫比濁法 / 制限酵素KpnI / 遺伝型分類 / 表現型分類 / アポ(a)イソ型 / LIA法 / TIA法 / アポ(a) / Plasminogen / Fibrinolysis / Coagulation / Interleukin-6 / Acute phase reactant / Coronary artery disease / Lp(a) phenotype / Lipoprotein(a) / イオン強度 / トリグリセリド・リッチ・リポ蛋白 / アポ(a)表現型 / 糖尿病 / リポ蛋白(a)[Lp(a)] / 組織修復 / 血液凝固線溶系 / プラスミノーゲン / 血液凝固線溶 / インターロイキン-6 / 急性相反応 / リポ蛋白(a) / 癌進展 / 癌免疫療法 / 癌転移 / NKT細胞 / 免疫抑制因子 / 一酸化窒素 / 腫瘍免疫 / NKT細胞 / α- ガラクトシルセラミド / IDO / 腫瘍 / NKT細胞免疫療法 / α-ガラクトシルセラミド / トリプトファン代謝 / 臨床化学 / 炎症・免疫 / 生理活性物質 / 臨床検査医学 / 生存率 / LPS / ガラクトースアミン / IL-6 / 急性肝障害モデル / 骨髄移植 Less
  • Research Projects

    (28 results)
  • Research Products

    (52 results)
  • Co-Researchers

    (38 People)
  •  Fundamental study on the lipid lowering peptides derived from food proteins

    • Principal Investigator
      Nagaoka Satoshi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Eating habits
    • Research Institution
      Gifu University
  •  Development of an HBV infection mouse model using HSV-TK-WT mouse

    • Principal Investigator
      Ito Hiroyasu
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Gifu University
  •  Inhibition of iNOS activity enhances the anti-tumor effects of alpha-galactosylceramide in cancer model

    • Principal Investigator
      Ito Hiroyasu
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Gifu University
  •  The role of IDO in the HBV-related liver diseases.Principal Investigator

    • Principal Investigator
      SEISHIMA Mitsuru
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Gifu University
  •  The investigation of immune regulation by IDO in NKT cell-mediated immunotherapy

    • Principal Investigator
      HOSHI Masato
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Laboratory medicine
    • Research Institution
      Suzuka University of Medical Science
  •  Screening and gene analysis for the protection from muscle damage by statin drugsPrincipal Investigator

    • Principal Investigator
      SEISHIMA Mitsuru
    • Project Period (FY)
      2009 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory medicine
    • Research Institution
      Gifu University
  •  The pathophysiologic role of indoleamine 2, 3-dioxygenase in viral infectious diseases

    • Principal Investigator
      SAITOU Kuniaki
    • Project Period (FY)
      2008 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory medicine
    • Research Institution
      Kyoto University
  •  Study on the mechanism of rhabdomyosis induced by statins and gene analysis of patients with rhalxiomyasis

    • Principal Investigator
      TAKEMURA Masao, 和田 久泰
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Gifu University
  •  Study on analytical system for the etiology of autoimmune disease using two-dimensional nano LC/MSPrincipal Investigator

    • Principal Investigator
      SEISHIMA Mitsuru
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory medicine
    • Research Institution
      Gifu University
  •  The Role of the Tumor Necrosis Factor Receptor in 2,4,6-Trinitrobenzene Sulphonic Acid (TNBS)-induced Colitis in Mice

    • Principal Investigator
      KATO Tomohiro
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      GIFU UNIVERSITY
  •  マウス骨髄移植技術を用いた肝不全発症機構の解明とその臨床応用に関する研究

    • Principal Investigator
      YAMADA Yasuhiro
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Gifu University
  •  Mechanism of action of new hypocholesterolemic pentapeptidei

    • Principal Investigator
      NAGAOKA Satoshi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      食品科学・栄養科学
    • Research Institution
      Gifu University
  •  The role of proinflammatory cytokines in the generation of myocardial ischemia/reperfusion injury

    • Principal Investigator
      WADA Hisayasu
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Gifu University
  •  Proteome analysis of human macrophage cells associated with atherosclerosis

    • Principal Investigator
      FUJII Hidehiko
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Gifu University
  •  Study on the mechanism of atherosclerotic lesion formation using cytokine-knockout mousePrincipal Investigator

    • Principal Investigator
      SEISHIMA Mitsuru
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory medicine
    • Research Institution
      Gifu University
  •  A mechanism of HIV-related dementia complex - relation between TNF-α and dementia -

    • Principal Investigator
      SAITO Kuniaki
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Gifu University
  •  The analysis of the mechanism of the anti-atherogenic action of polyphenol utilizing new evaluation technology

    • Principal Investigator
      NAGAOKA Satoshi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      食品科学・栄養科学
    • Research Institution
      Gifu University
  •  The method for determination of serum lipid-free apolipoprotein concentration and its clinical applicationPrincipal Investigator

    • Principal Investigator
      SEISHIMA Mitsuru
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory medicine
    • Research Institution
      Gifu University
  •  A study of the role of cytokines in the development of atherosclerosis using double knockout mice

    • Principal Investigator
      WADA Hisayasu, 藤井 秀比古
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Gifu University
  •  New screenings of the improving factors for lipid metabolism derived from foods and their functional evaluation

    • Principal Investigator
      NAGAOKA Satoshi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      食品科学・栄養科学
    • Research Institution
      Gifu University
  •  The role of proinflammatory cytokines in the development and progression of viral myocarditis

    • Principal Investigator
      WADA Hisayasu
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Gifu University
  •  Significance of soluble Fas and its related cytokines in serum of rheumatoid arthritis patients.

    • Principal Investigator
      TAKEUCHI Shoji
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Gifu University
  •  The mechanism for synthesis and secretion of apo A-IV in CaCo-2 cellsPrincipal Investigator

    • Principal Investigator
      SEISHIMA Mitsuru
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Gifu University School of Medicine
  •  Basic studies of immunotherapy in relation to the serum soluble interleukin-2 receptor determination in patients with rheumatoid arthritis

    • Principal Investigator
      TAKEUCHI Shoji
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Gifu University
  •  Study on apo A-IV polymorphism in patients with hyperlipidemia.Principal Investigator

    • Principal Investigator
      SEISHIMA Mitsuru
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Gifu University
  •  Clinical studies of adoptive immunochemotherapy combined with anti-cancer agents in the treatment of malignant bone tumor

    • Principal Investigator
      TAKTEUCHI Shoji
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Gifu University
  •  Developments and clinical evaluations of easy-to-perform and rapid measurements of serum Lp(a) concentrations and apo(a) isoforms.

    • Principal Investigator
      NOMA Akio
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Laboratory medicine
    • Research Institution
      Gifu University
  •  Study on the physiological and pathological significances of lipoprotein(a).

    • Principal Investigator
      NOMA Akio
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Laboratory medicine
    • Research Institution
      Gifu University

All 2015 2014 2013 2012 2011 2010 2009 2006

All Journal Article Presentation Book

  • [Book] 標準臨床検査医2012

    • Author(s)
      清島 満 標準臨床検査医学(高木 康・山田康幸編)
    • Publisher
      学医学書院, 東京
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Book] 病理学入門2011

    • Author(s)
      清島
    • Publisher
      昭和堂, 京都
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Book] 病理学入門2011

    • Author(s)
      清島満(分担執筆)内藤通孝編
    • Total Pages
      273
    • Publisher
      昭和堂
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Journal Article] Inhibition of iNOS activity enhances the anti-tumor effects of alpha-galactosylceramide in established murine cancer model.2015

    • Author(s)
      Ito H, Ando T, Seishima M.
    • Journal Title

      Oncotarget.

      Volume: 6(39) Issue: 39 Pages: 41863-41874

    • DOI

      10.18632/oncotarget.6172

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25460679
  • [Journal Article] Combination therapy with α-galactosylceramide and a Toll-like receptor agonist exerts an augmented suppressive effect on lung tumor metastasis in a mouse model.2015

    • Author(s)
      Ando T, Ito H, Arioka Y, Ogiso H, Seishima M.
    • Journal Title

      Oncology Reports

      Volume: 33 Issue: 2 Pages: 826-832

    • DOI

      10.3892/or.2014.3634

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25460679
  • [Journal Article] Inhibition of indoleamine 2,3-dioxygenase activity enhances the anti-tumour effects of a Toll-like receptor 7 agonist in an established cancer model.2015

    • Author(s)
      Ito H, Ando T, Arioka Y, Saito K, Seishima M.
    • Journal Title

      Immunology

      Volume: 144(4) Issue: 4 Pages: 621-630

    • DOI

      10.1111/imm.12413

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460679
  • [Journal Article] Inhibition of induced nitric oxide synthase enhances the anti-tumor effects on cancer immunotherapy using TLR7 agonist in mice.2015

    • Author(s)
      Ito H, Ando T, Ogiso H, Arioka Y, Seishima M.
    • Journal Title

      Cancer Immunol Immunother.

      Volume: 64(4) Issue: 4 Pages: 429-436

    • DOI

      10.1007/s00262-014-1644-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460679
  • [Journal Article] Induction of HBsAg-specific cytotoxic T lymphocytes can be up-regulated by the inhibition of indoleamine 2, 3-dioxygenase activity2014

    • Author(s)
      Ito H, Ando T, Ando K, Ishikawa T, Saito K, Moriwaki H, Seishima M
    • Journal Title

      Immunology

      Volume: 印刷中 Issue: 4 Pages: 614-623

    • DOI

      10.1111/imm.12274

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390149, KAKENHI-PROJECT-24659361
  • [Journal Article] Kynurenine production mediated by indoleamine 2, 3-dioxygenase aggravates liver injury in HBV-specific CTL-induced fulminant hepatitis2014

    • Author(s)
      Ohtaki H, Ito H, Ando K, Ishikawa T, Hoshi M, Ando T, Takamatsu M, Hara A, Moriwaki H, Saito K, Seishima M
    • Journal Title

      Biochim Biophys Acta

      Volume: 1842(9) Issue: 9 Pages: 1464-71

    • DOI

      10.1016/j.bbadis.2014.04.015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390149, KAKENHI-PROJECT-24659361, KAKENHI-PROJECT-26860376
  • [Journal Article] Kynurenine production mediated by indoleamine 2,3-dioxygenase aggravates liver injury in HBV-specific CTL-induced fulminant hepatitis2014

    • Author(s)
      Ohtaki H, Ito H, Ando K, Ishikawa T, Hoshi M, Ando T, Takamatsu M, Hara A, Moriwaki H, Saito K, Seishima M
    • Journal Title

      Biochim Biophys Acta

      Volume: S0925-4439(14) Pages: 102-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24890270
  • [Journal Article] Resveratrol reverses remodeling in hearts with large, old myocardial infarctions through enhanced autophagy-activating AMP kinase pathway2013

    • Author(s)
      Kanamori H, Takemura G, Goto K, Tsujimoto A, Ogino A, Takeyama G, Kawaguchi T, Watanabe T, Morishita K, Kawasaki M, Mikami A, Fujiwara T, Fujiwara H, Seishima M, Minatoguchi S.
    • Journal Title

      Am J Pathol

      Volume: 182 Issue: 3 Pages: 701-13

    • DOI

      10.1016/j.ajpath.2012.11.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390179, KAKENHI-PROJECT-24790751
  • [Journal Article] Suppression of azoxymethane-induced colonic preneoplastic lesions in rats by 1-methyltryptophan, an inhibitor of indoleamine 2, 3-dioxygenase2012

    • Author(s)
      Ogawa K, Hara T, Shimizu M, Ninomiya S, Nagano J, Sakai H, Hoshi M, Ito H, Tsurumi H, Saito K, Seishima M, Tanaka T, Moriwaki H
    • Journal Title

      Cancer Sci

      Volume: 103 Issue: 5 Pages: 951-958

    • DOI

      10.1111/j.1349-7006.2012.02237.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590838, KAKENHI-PROJECT-24890270
  • [Journal Article] High susceptibility to lipopolysaccharide-induced lethal shock in encephalomyocarditis virus-infected mice2012

    • Author(s)
      Ohtaki H
    • Journal Title

      Sci Rep.

      Volume: 2 Issue: 1 Pages: 367-375

    • DOI

      10.1038/srep00367

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790787, KAKENHI-PROJECT-24890270
  • [Journal Article] L-tryptophan-kynurenine pathway metabolites regulate type 1 IFNs of acute viral myocarditis in mice2012

    • Author(s)
      Hoshi M
    • Journal Title

      J Immunol

      Volume: 188 Issue: 8 Pages: 3980-3987

    • DOI

      10.4049/jimmunol.1100997

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390179, KAKENHI-PROJECT-23390149, KAKENHI-PROJECT-23790787, KAKENHI-PROJECT-24890270
  • [Journal Article] Pre-administration of L-tryptophan improved ADR-induced early renal failure in mice2012

    • Author(s)
      Arioka Y
    • Journal Title

      Life Sci

      Volume: 59 Issue: 3-4 Pages: 100-106

    • DOI

      10.1016/j.lfs.2012.06.018

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390179, KAKENHI-PROJECT-23390149, KAKENHI-PROJECT-24890270
  • [Journal Article] Inhibition of increased indoleamine 2, 3-dioxygenase activity attenuates Toxoplasma gondii replication in the lung during acute infection2012

    • Author(s)
      Murakami Y, Hoshi M, Hara A, Takemura M, Arioka Y, Yamamoto Y, Matsunami H, Funato T, Seishima M, Saito K
    • Journal Title

      Cytokine

      Volume: 59(2) Issue: 2 Pages: 245-51

    • DOI

      10.1016/j.cyto.2012.04.022

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390149, KAKENHI-PROJECT-24890270
  • [Journal Article] -Epigallocatechin gallate inhibits the expression of indoleamine 2,3-dioxygenase in human colorectal cancer cells2012

    • Author(s)
      Ogawa K, Hara T, Shimizu M, Nagano J, Ohno T, Hoshi M, Ito H, Tsurumi H, Saito K, Seishima M, Moriwaki H
    • Journal Title

      Oncol Lett

      Volume: 4(3) Pages: 546-550

    • URL

      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673646/

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24890270
  • [Journal Article] Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression.2011

    • Author(s)
      Osawa Y, Seki E, Kodama Y, Suetsugu A, Miura K, Adachi M, Ito H, Shiratori Y, Banno Y, Olefsky JM, Nagaki M, Moriwaki H, Brenner DA, Seishima M
    • Journal Title

      FASEB J

      Volume: 25 Issue: 4 Pages: 1133-44

    • DOI

      10.1096/fj.10-168351

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390179, KAKENHI-PROJECT-22590728
  • [Journal Article] Indoleamine 2, 3-dioxygenase in tumor tissue indicates prognosis in patients with diffuse large B-cell lymphoma treated with R-CHOP2011

    • Author(s)
      Ninomiya S, Hara T, Tsurumi H, Hoshi M, Kanemura N, Goto N, Kasahara S, Shimizu M, Ito H, Saito K, Hirose Y, Yamada T, Takahashi T, Seishima M, Takami T, Moriwaki H.
    • Journal Title

      Ann Hematol.

      Volume: 90(4) Issue: 4 Pages: 409-16

    • DOI

      10.1007/s00277-010-1093-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390167
  • [Journal Article] L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin2011

    • Author(s)
      Osawa Y, Kanamori H, Seki E, Hoshi M, Ohtaki H, Yasuda Y, Ito H, Suetsugu A, Nagaki M, Moriwaki H, Saito K, Seishima M
    • Journal Title

      Journal of Biological Chemistry

      Volume: 286 Issue: 40 Pages: 34800-34808

    • DOI

      10.1074/jbc.m111.235473

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J06850, KAKENHI-PROJECT-20390167, KAKENHI-PROJECT-21390179
  • [Journal Article] Comparison of chemiluminescence enzyme immunoassay (CLEIA) with ELISA for the determination of anti-cyclic citrullinated peptide antibodies2010

    • Author(s)
      Tanaka R, Takemura M, Sato M, Yamada Y, Nakagawa T, Horibe T, Hoshi M, Ohtaki H, Ito H, Seishima M, Shimizu K.
    • Journal Title

      Clin Chim Acta

      Volume: 411 Issue: 1-2 Pages: 22-5

    • DOI

      10.1016/j.cca.2009.09.032

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Journal Article] リポ蛋白X2010

    • Author(s)
      清島満、伊藤弘康
    • Journal Title

      日本臨床

      Volume: 68 Pages: 46-49

    • Data Source
      KAKENHI-PROJECT-21390179
  • [Journal Article] Serum concentration of L-kynureninepredicts the clinical outcome of patientswith diffuse large B-cell lymphoma treated with R-CHOP2010

    • Author(s)
      Yoshikawa T, Hara T, Tsurumi H, Goto N, Hoshi M, Kitagawa J, Kanemura N, Kasahara S, Ito H, Takemura M, Saito K, Seishima M, Takami T, Moriwaki H.
    • Journal Title

      Eur J Haematol.

      Volume: 84(4) Issue: 4 Pages: 304-309

    • DOI

      10.1111/j.1600-0609.2009.01393.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390167
  • [Journal Article] Ability of IDO to attenuate liver in juryin alpha-galactosylceramide-in duced hepatitis model2010

    • Author(s)
      Ito H, Hoshi M, Ohtaki H, Taguchi A, AndoK, Ishikawa T, Osawa Y, Hara A, Moriwaki H, Saito K, Seishima M.
    • Journal Title

      J Immunol.

      Volume: 185(8) Issue: 8 Pages: 4554-60

    • DOI

      10.4049/jimmunol.0904173

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390167
  • [Journal Article] Lp(a)2010

    • Author(s)
      清島満、金森寛充、服部高幸
    • Journal Title

      Medicina

      Volume: 47 Pages: 254-256

    • Data Source
      KAKENHI-PROJECT-21390179
  • [Journal Article] The absence of IDO upregulates type I IFN production, resulting in suppression of viral replication in the retrovirus-infected mouse2010

    • Author(s)
      Hoshi M, Saito K, Hara A, Taguchi A, OhtakiH, Tanaka R, Fujigaki H, Osawa Y, TakemuraM, Matsunami H, Ito H, Seishima M.
    • Journal Title

      J Immunol.

      Volume: 185(6) Issue: 6 Pages: 3305-12

    • DOI

      10.4049/jimmunol.0901150

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390167
  • [Journal Article] Changes in serum tryptophan catabolism as an indicator of disease activity in adult T-cell leukemia/lymphoma2009

    • Author(s)
      Hoshi M, Ito H, Fujigaki H, Takemura M, Takahashi T, Tomita E, Ohyama M, Tanaka R, Ohtaki H, Saito K, Seishima M.
    • Journal Title

      LeukLymphoma.

      Volume: 50(8) Issue: 8 Pages: 1372-1374

    • DOI

      10.1080/10428190903045393

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390167
  • [Journal Article] Interaction between LPS-induced NO production and IDO activity in mouse peritoneal cells in the presence of activated Valpha14 NKT cells2009

    • Author(s)
      Ohtaki H, Ito H, Ando K, Ishikawa T, HoshiM, Tanaka R, Osawa Y, Yokochi T, MoriwakiH, Saito K, Seishima M.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 389(2) Issue: 2 Pages: 229-34

    • DOI

      10.1016/j.bbrc.2009.08.120

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390167
  • [Journal Article] Statin-induced Ca2+release wasincreased in B lymphocytes in patients who showed elevated serum creatine kinase during statin treatment.2009

    • Author(s)
      Hattori T, Saito K, Takemura M, Ito H, Ohta H, Wada H, Sei Y, Kawamura M,Seishima M.
    • Journal Title

      J Atheroscler Thromb

      Volume: 16 Pages: 870-7

    • URL

      https://www.jstage.jst.go.jp/browse/jat

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Journal Article] Marked increases in hippocampal neuron indoleamine 2, 3-dioxygenase via IFN-gamma-independent pathway following transient global ischemia in mouse2009

    • Author(s)
      Hoshi M, Saito K, Murakami Y, Taguchi A, Fujigaki H, Tanaka R, Takemura M, Ito H, Hara A, Seishima M.
    • Journal Title

      Neurosci Res.

      Volume: 63(3) Issue: 3 Pages: 194-198

    • DOI

      10.1016/j.neures.2008.12.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390167
  • [Journal Article] The signal transducer and activator of trenscription 1α and interferon regulatory factor 1are not essential for the induction of indoleamine 2,3-dioxygenase by lipopolysaccharide : involvement of p38 mitogen-activated protein kinase and nuclear factor-κ B pathways, and synergistic effect of several proinflammatory cytokines.2006

    • Author(s)
      Fujigaki H, Saito K, Fujigaki S, Takemura M, Sudo K, lshiguro H, Seishima M.
    • Journal Title

      The Journal of Biochemistry 139(4)

      Pages: 655-662

    • Data Source
      KAKENHI-PROJECT-18590525
  • [Journal Article] Nitration and inactivation of IDO by peroxynitrite.2006

    • Author(s)
      Fujigaki H, Saito K, Lin F, Fujigaki S, Takahashi K, Martin BM, Chen CY, Masuda J, Kowalak J, Takikawa O, Seishima M, Markey SP.
    • Journal Title

      The Journal of Immunology 176(1)

      Pages: 372-379

    • Data Source
      KAKENHI-PROJECT-17390161
  • [Journal Article] Serum-soluble tumor factor receptor 2 (sTNF-R2) level determines clinical outcome in patients with aggressive non-Hodgkin's lymphoma.2006

    • Author(s)
      Goto N, Tsurumi H, Takemura M, Hara T, Sawada M, Kasahara S, Kanemura N, Yamada T, Shimizu M, Takahashi T, Tomita M, Seishima M, Takami T, Moriwaki H.
    • Journal Title

      European Journal of Haematology 77(3)

      Pages: 217-225

    • Data Source
      KAKENHI-PROJECT-17390161
  • [Journal Article] Nitration and inactivation of indoeamine 2,3-dioxygenase by peroxynitrite2006

    • Author(s)
      Fujigaki H, Saito K, Seishima M他
    • Journal Title

      J.Immunol 176

      Pages: 372-379

    • Data Source
      KAKENHI-PROJECT-17390161
  • [Journal Article] The signal transducer and activity of transcription 1a and interferon regulatory factor 1 are not essential for the induction of indoleamine 2,3-dioxygenase by lipopolysaccharide2006

    • Author(s)
      Fujigaki H, Saito K, Seishima M他
    • Journal Title

      J.Biochem. (In Press)

    • Data Source
      KAKENHI-PROJECT-17390161
  • [Presentation] Toll様受容体アゴニストと一酸化窒素合成酵素の抑制を用いた抗腫瘍効果の検討2015

    • Author(s)
      伊藤弘康、安藤達也、小木曽英介、清島 満
    • Organizer
      第62回日本臨床検査医学会学術集会
    • Place of Presentation
      岐阜市
    • Year and Date
      2015-11-20
    • Data Source
      KAKENHI-PROJECT-25460679
  • [Presentation] インドールアミン酸素添加酵素の発現制御を用いたHBV特異的細胞障害性T細胞誘導効果の検討2013

    • Author(s)
      伊藤弘康、安藤達也、石川哲也、清島満
    • Organizer
      第60回日本臨床検査医学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-24659361
  • [Presentation] マウスB型急性肝炎モデルにおけるインドールアミン酸素添加酵素の解析2013

    • Author(s)
      伊藤弘康、大瀧博文、安藤達也、安藤量基、石川哲也、森脇久隆、清島満
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24659361
  • [Presentation] インドールアミン酸素添加酵素の発現抑制によるHBV特異的細胞障害性T細胞誘導効果2013

    • Author(s)
      伊藤弘康、安藤量基、石川哲也、森脇久隆、清島満
    • Organizer
      第40回日本肝臓学会西部会
    • Place of Presentation
      岐阜
    • Data Source
      KAKENHI-PROJECT-24659361
  • [Presentation] Is the measurement of Ca2+-release inCD19+ B cells stimulated by statin useful for prediction of muscle damage as a side effect?2012

    • Author(s)
      Mori I, Hattori T, Osawa Y, Kanamori H, Kajita K, Morita H, Ishizuka T, Saito K, Ito H, Seishima M
    • Organizer
      第44回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      福岡市
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Presentation] 脂質異常症の治療~動脈硬化予防の戦略として~2012

    • Author(s)
      清島 満
    • Organizer
      第59回日本臨床検査医学会学術集会(招待講演)
    • Place of Presentation
      京都市
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Presentation] 検査情報を生かすための病態情報解析医学に学ぶ.2012

    • Author(s)
      清島 満
    • Organizer
      第4回日本臨床一般検査学会学術集会(招待講演)
    • Place of Presentation
      岐阜市
    • Year and Date
      2012-10-27
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Presentation] 細胞障害性T細胞により誘発されるマウス劇症肝炎モデルにおける indoleamine 2, 3-dioxygenaseの解析2012

    • Author(s)
      安藤 達也、清島 満ら
    • Organizer
      第59回日本臨床検査医学会学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-24659361
  • [Presentation] 脂質異常症の治療~動脈硬化予防の戦略として~2012

    • Author(s)
      清島 満
    • Organizer
      第59回日本臨床検査医学学術集会
    • Place of Presentation
      京都市
    • Invited
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Presentation] 検査情報を活かすための病態情報解析医学に学ぶ2012

    • Author(s)
      清島 満
    • Organizer
      第4回日本臨床一般検査学会学術集会
    • Place of Presentation
      岐阜市
    • Invited
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Presentation] 細胞障害性T細胞により誘発されるマウス劇症肝炎モデルにおけるindoleamine 2, 3-dioxygenaseの解析2012

    • Author(s)
      安藤達也、大瀧博文、伊藤弘康、星雅人、石川哲也、斎藤邦明、清島満
    • Organizer
      第59回日本臨床検査医学会学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-24659361
  • [Presentation] Inhibition of acid sphingomyelinase causes hepatic glucose intolerance and insulin resistance2010

    • Author(s)
      Osawa Y, Ito H, Suetusgu A, Nagaki M, Moriwaki H, Seishima M
    • Organizer
      DDW 2010
    • Place of Presentation
      New Orlealls
    • Year and Date
      2010-05-03
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Presentation] 高脂血症治療剤による培養細胞に対するCa^<2+>放出効果の基礎的検討2010

    • Author(s)
      服部高幸、竹村正男、太田浩敏、大澤陽介、金森寛充、伊藤弘康、斎藤邦明、清島満
    • Organizer
      第49回日本臨床検査医学会東海・北陸支部総会第320回日本臨床化学会東海北陸支部例会連合大会
    • Place of Presentation
      名古屋市
    • Year and Date
      2010-03-14
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Presentation] Ca2+releasing effect of stains on human CD19+primary B cells.2010

    • Author(s)
      Hattori T, Saito K, Takemura M, Ito H, Ohta H, Wada H, Sei Y, Kawamura M, Seishima M
    • Organizer
      第42回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      岐阜市
    • Year and Date
      2010-06-15
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Presentation] Inhibition of acid sphingomyelinasecauses hepatic glucose intolerance and insulin resistance2010

    • Author(s)
      Osawa Y, Ito H, Suetsugu A, Nagaki M, Moriwaki H, Seishima M.
    • Organizer
      DDW 2010 New Orleans
    • Place of Presentation
      USA
    • Year and Date
      2010-05-03
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Presentation] Ca^<2+> releasing effect of statins on human CD19+ primary B cells2010

    • Author(s)
      Hattori T, Saito K, Takemura M, Ito H, Ohta H, Wada H, Sei Y, Kawamura M, Seishima M
    • Organizer
      第42回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      岐阜市
    • Year and Date
      2010-06-15
    • Data Source
      KAKENHI-PROJECT-21390179
  • [Presentation] 高脂血症治療剤による培養細胞に対するCa2+放出効果の基礎的検討2010

    • Author(s)
      服部高幸、竹村正男、太田浩敏、 大澤陽介、金森寛充、伊藤弘康、斎藤邦明、清島 満
    • Organizer
      第49回日本臨床検査医学会東海・北陸支部総会 第320回日本臨床化学会東海・北陸支部例会 連合大会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-03-14
    • Data Source
      KAKENHI-PROJECT-21390179
  • 1.  SAITOU Kuniaki (80262765)
    # of Collaborated Projects: 16 results
    # of Collaborated Products: 22 results
  • 2.  WADA Hisayasu (10283300)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 1 results
  • 3.  ITO Hiroyasu (80373075)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 27 results
  • 4.  YAMADA Yasuhiro (10324295)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 5.  NOMA Akio (30208384)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 6.  NAGAOKA Satoshi (50202221)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 7.  FUJII Hidehiko (50301213)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 8.  TAKTEUCHI Shoji (50021473)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  ABE Akira (30175898)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  MAKINO Kazuhiko (80181618)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  MORITA Toshiko (30242746)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  TAKEMURA Masao (80402155)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 13.  SEKIKAWA Kenji
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  YAMAMOTO Yasuko (00331869)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 15.  FUNATO Tadao (70165455)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  OSAWA Yousuke (60447787)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 17.  MORI Ichiro (40444327)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 18.  KANAMORI Hiromitsu (20456502)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 19.  HOSHI Masato (40633996)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 20.  SHIRAKAMI Yohei (50632816)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  OKUNO Masataka (10204140)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  SHIMOKAWA Kuniyasu (70021376)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  MINATOGUCHI Shinya (20190697)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  NABESHIMA Toshitaka (70076751)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  KATO Tomohiro (40224521)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  MORIWAKI Hisataka (50174470)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 27.  中村 容子 (90227950)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  石川 哲也 (10288508)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  松井 利郎 (20238942)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  上野 義仁 (20250467)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  本多 裕之 (70209328)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  YOSHIMURA Yoshimichi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  TSUKADA Yutaka
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  SAITO Kazunori
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  Kanbe Ayumu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  斎藤 和典
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  SHIMIZU Masahito
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 38.  MURAKAMI Yuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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