OGURA Kenichiro 小倉健一郎

… Alternative Names

小倉健一郎オグラケンイチロウ

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Researcher Number	10185564
Other IDs
Affiliation (Current)	2025: 東京薬科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2012 – 2014: 東京薬科大学, 薬学部, 准教授 2007: Tokyo University of Pharmacy and Life Science, School of Pharmacy, Associate Professor 2004 – 2006: Tokyo University of Pharmacy and Life Science, School of Pharmacy, associate professor, 薬学部, 助教授 2002 – 2003: 東京薬科大学, 薬学部, 講師 1990 – 1993: 東京薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Medical pharmacy / Biological pharmacy Except Principal Investigator Biological pharmacy
Keywords	Principal Investigator UGT / グルクロン酸抱合 / 抱合反応 / 乳がん / タモキシフェン / 耐性化 / 乳癌 / anti cancer drug / glucuronidation / resistance … More / breast cancer / tamoxifen / 抗癌薬 / 抗がん剤耐性 / 抗がん薬 / conjugation reaction / excretion / metabolism / glucuronic acid conjugation / sulfate conjugation / daidzein / genistein / phytoestrogen / 排泄 / 代謝 / 硫酸抱合 / ダイゼイン / ゲニステイン / 植物エストロゲン / エストロゲン受容体 / 抗がん剤耐性化 / 抗がん剤 / MCF-7 / 薬物代謝酵素 / アミノ酸置換 / 大腸菌 / ラット肝 / 部位特異的変異 / 発現 / ヒドロキシステロイドスルホトランスフェラーゼ / cDNAクローニング / スルホトランスフェラーゼ … More Except Principal Investigator Aging / Marker Substanec in Aging / Cholesterol Hydroperoxide / Phospholipid Hydroperoxide / Glutathione S-Transferase / Biomembrane / Lipid Peroxidation / Oxygen Free Radical / グルタチオントランスフェラ-ゼ / 肝細胞質 / 脂質過酸化物 / グルタチオンペルオキシダ-ゼ / グルタチオン / 酸素フリ-ラジカル / 肝ミクロソ-ム / 脂肪酸ヒドロペルオキシド / cDNAクローニング / グルタチオンペルオキシダーゼ活性 / 生体膜防御機構 / 過酸化脂質 / ミクロソーム / ラット肝 / 老化 / 加齢マーカー物質 / コレステロールヒドロペルオキシド / リン脂質ヒドロペルオキシド / グルタチオンS-トランスフェラーゼ / 生体膜 / 脂質過酸化 / 酸素フリーラジカル Less

Role of drug metabolizing enzymes in acquired resistance of breast cancer cells to anticancer drugsPrincipal Investigator
- Principal Investigator
  
  OGURA Kenichiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Mechanisms of acquired tamoxifen-resistance of breast cancer cellsPrincipal Investigator
- Principal Investigator
  
  OGURA Kenichiro
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Metabolism of the phytoestrogens by sulfate and glucuronic acid conjugation reactionsPrincipal Investigator
- Principal Investigator
  
  OGURA Kenichiro
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
部位特異的遺伝子変異法によるスルホトランスフェラーゼの構造活性相関の解明Principal Investigator
- Principal Investigator
  
  小倉健一郎
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
A Novel Mechanism for Protecting of Biomembrane from Oxidative Disorder by Oxygen Free Radicals
- Principal Investigator
  
  WATABE Tadashi
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo College of Pharmacy

All 2015 2006 2005

All Journal Article Presentation

[Journal Article] Quaternary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen, an active metabolite of tamoxifen, by human liver microsomes and UDP-glucuronosyltransferase 1A42006
- Author(s)
  K. Ogura, et. al.
- Journal Title
  
  Biochem. Pharmacol 71
  
  Pages: 1358-1369
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590137
[Journal Article] Quatemary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen,an active metabolite of tamoxifen,by human liver microsomes and UDP-glucuronosyltransferase 1A42006
- Author(s)
  Ogura K., et. al.
- Journal Title
  
  Biochem.Pharmacol. 71
  
  Pages: 1358-1369
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590137
[Journal Article] Quaternary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen, an active metabolite of tamoxifen, by human liver microsomes and UDP-glucuronosyltransferase 1A42006
- Author(s)
  Ogura K., et al.
- Journal Title
  
  Biochemical Pharmacology 71
  
  Pages: 1358-1369
- Data Source
  KAKENHI-PROJECT-17590137
[Presentation] タモキシフェン耐性MCF-7細胞における細胞増殖調節因子の発現変動2015
- Author(s)
  小倉健一郎、木下　隼、大沼友和、西山貴仁、平塚　明
- Organizer
  日本薬学会第135年会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-24590217
[Presentation] Acquired tamoxifen resistance in MCF-7 cells by overexpression of UDP-glucuronosyltransferase2006
- Author(s)
  Ogura, K., et. al.
- Organizer
  21th JSSX Meeting
- Place of Presentation
  Tokyo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590137
[Presentation] Acquired tamoxifen resistance in MCF-7 cells by overexpression of UDP-glucuronosyltransferase2006
- Author(s)
  Ogura K., et. al.
- Organizer
  第21回日本薬物動態学会年会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590137
[Presentation] Quaternary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen, an active metabolite of tamoxifen, by human liver microsomes and UDP-glucuronosyltransferase 1A42005
- Author(s)
  Ogura, K., et. al.
- Organizer
  13th NA ISSX Meeting/20th ISSX Meeting
- Place of Presentation
  Maui, Hawaii, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590137
[Presentation] N-Glucuronidation of 4-hydroxytamoxifen, an active metabolite of tamoxifen2005
- Author(s)
  Ogura K., et. al.
- Organizer
  13th NA ISSX Meeting/20th JSSX Meeting
- Place of Presentation
  Maui,Hawaii,USA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590137

1. WATABE Tadashi (00057316)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. OKUDA Haruhiro (30160807)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. HIRATSUKA Akira (20165179)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OGURA Kenichiro 小倉 健一郎

小倉 健一郎 オグラ ケンイチロウ

Research Projects

Research Products

Co-Researchers

Role of drug metabolizing enzymes in acquired resistance of breast cancer cells to anticancer drugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of acquired tamoxifen-resistance of breast cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Metabolism of the phytoestrogens by sulfate and glucuronic acid conjugation reactionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

部位特異的遺伝子変異法によるスルホトランスフェラーゼの構造活性相関の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A Novel Mechanism for Protecting of Biomembrane from Oxidative Disorder by Oxygen Free Radicals

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Quaternary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen, an active metabolite of tamoxifen, by human liver microsomes and UDP-glucuronosyltransferase 1A42006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Quatemary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen,an active metabolite of tamoxifen,by human liver microsomes and UDP-glucuronosyltransferase 1A42006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Quaternary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen, an active metabolite of tamoxifen, by human liver microsomes and UDP-glucuronosyltransferase 1A42006

Author(s)

Journal Title

Data Source

[Presentation] タモキシフェン耐性MCF-7細胞における細胞増殖調節因子の発現変動2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Acquired tamoxifen resistance in MCF-7 cells by overexpression of UDP-glucuronosyltransferase2006

Author(s)

Organizer

Place of Presentation

Description

Data Source

[Presentation] Acquired tamoxifen resistance in MCF-7 cells by overexpression of UDP-glucuronosyltransferase2006

Author(s)

Organizer

Place of Presentation

Description

Data Source

[Presentation] Quaternary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen, an active metabolite of tamoxifen, by human liver microsomes and UDP-glucuronosyltransferase 1A42005

Author(s)

Organizer

Place of Presentation

Description

Data Source

[Presentation] N-Glucuronidation of 4-hydroxytamoxifen, an active metabolite of tamoxifen2005

Author(s)

Organizer

Place of Presentation

Description

Data Source

OGURA Kenichiro 小倉健一郎

小倉健一郎オグラケンイチロウ