OKUNO Masataka 奥野正隆

Researcher Number	10204140
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2004: 国立大学法人岐阜大学, 医学部消化器病態学第一内科, 助教授 2004: 岐阜大学, 大学院・医学研究科, 助教授 2003: 岐阜大学, 医学部第一内科, 助教授 2002 – 2003: Fist Dept of Internal Medicide Gifu University School of Medicine Associate Professor, 医学部, 助教授 2002 – 2003: 岐阜大学, 医学部・第一内科, 助教授 … More 2000 – 2001: GIFU UNIVERSITY,SCHOOL OF MEDICINE, 医学部・附属病院, 講師 1998 – 1999: GIFU UNIVERSITY,SCHOOL OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 助手 1997: 岐阜大学, 医学部付属病院, 助手 1996 – 1997: First Department of Internal Medicine Gifu University School of Medicine Assistant Professor, 医学部・附属病院, 助手 1994 – 1996: 岐阜大学, 医学部附属病院, 助手 1994: 岐阜大学, 医学部・附属病院, 助手 1992: University Hospital Assistant, 医学部附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology Except Principal Investigator Gastroenterology / Gastroenterology / Laboratory medicine / Biological Sciences
Keywords	Principal Investigator TGF-β / 肝線維化 / protease inhibitor / IFN-γ / TNF-α / 肝星細胞 / Collagen / Liver Fibrosis / transforming growth factor-β / コラーゲン … More / 伊東細胞 / レチノイド / kallikrein / cytokine / impaired liver regeneration / INF-γ / プロテアーゼ阻害剤 / カリクレイン / サイトカイン / 肝再生不全 / sigmnal transduction / hepatic stellate cells / Liver fibrosis / TGF-B / 細胞内情報伝達 / プロテアーゼインヒビター / Hepatic Stellate Cell / Protease Inhibitor / Stellate Cell / TGF-beta / Retinoid / transforming growth factor-beta … More Except Principal Investigator レチノイド / 化学予防 / 分子標的 / クローン除去 / 肝癌 / Smad / Plasmin / 切断面認識抗体 / 肝星細胞 / プロテアーゼ阻害剤 / 血漿カリクレイン / プラスミン / TGF-β活性化 / STAT1 / アポトーシス / 核内受容体 / CASPASE / APOPTOSIS / DIFFERENTIATION INDUCTION / RETINOID X RECEPTOR / RETINOID / HEPATOCELLULAR CARCINOMA / CANCER CHEMOPREVENTION / 遺伝子変異 / レチノイドX受容体 / Hepatic stellate cells / Protease inhibitor / Cutting edge recognizing antibody / Plasma kallikrein / TGF-β activation / Fulminant hepatitis / 劇症肝炎 / Cutting Edge Antibody / Hepatic Stellate Cells / Protease Inhibitor / Plasma Kallikrein / TGF-β Activation / Impaired Liver Regeneration / Cirrhosis / Hepatic Fibrosis / 肝硬変 / 肝線維症 / 肝再生不全 / 肝線維化・肝硬変 / Interferon receptor / Retinoid / Apoptosis / Interferon / Immunoprevention / Chemoprevention / Liver cancer / 発癌予防 / 癌治療 / 分化誘導 / 癌細胞 / サイトカイン受容体 / サイトカイン / インターフェロン受容体 / インターフェロン / 免疫予防 / 肝発癌 / Plasminogen / Fibrinolysis / Coagulation / Interleukin-6 / Acute phase reactant / Coronary artery disease / Lp(a) phenotype / Lipoprotein(a) / イオン強度 / トリグリセリド・リッチ・リポ蛋白 / アポ(a)表現型 / 糖尿病 / ELISA法 / リポ蛋白(a)[Lp(a)] / 組織修復 / 血液凝固線溶系 / ラテックス免疫比濁法 / プラスミノーゲン / 血液凝固線溶 / インターロイキン-6 / 急性相反応 / 虚血性心疾患 / Lp(a)表現型 / リポ蛋白(a) / リン酸化 / レチノイドレセプター / レチノイ / 発癌 / 核受容体 Less

Detection and regulation of hepatic diseases targeting TGF-β activation reaction.
- Principal Investigator
  
  KOJIMA Soichi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  RIKEN
The role of cytokine cascade in impaired liver regeneration and development of candidate pharmaceutical(s) to regulate this mechanismPrincipal Investigator
- Principal Investigator
  
  MORIWAKI Hisataka, 奥野正隆
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
核受容体蛋白を標的分子としたがん化学予防の研究
- Principal Investigator
  
  MORIWAKI Hisataka
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
Retinoid upregulates the sensitivity of cancer cells to a cytokine by inducing the cytokine receptor
- Principal Investigator
  
  MORIWAKI Hisataka
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
Improvement of Hepatic fibrosis/cirrhosis and impaired liver regeneration using protease inhibitors
- Principal Investigator
  
  KOJIMA Soichi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The Institute of Physical and Chemical Research
Development of a drug that inhibit liver fibrosis by interfering with the signal transduction of TGF-βPrincipal Investigator
- Principal Investigator
  
  OKUNO Masataka
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
MECHANISMS OF CLONAL DELETION OF HEPATOCELLULAR CARCINOMA BY ACYCLICRETINOID
- Principal Investigator
  
  MORIWAKI Hisataka
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Gastroenterology
- Research Institution
  GIFU UNIVERSITY
Inhibition of Liver Fibrosis by Protease InhibitorsPrincipal Investigator
- Principal Investigator
  
  OKUNO Masataka
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
MECHANISMS OF REGULATION AND CONTROL OF HEPATOCARCINOGENESIS BY ACYCLIC RETINOID
- Principal Investigator
  
  MORIWAKI Hisataka
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  GIFU UNIVERSITY
Inhibition of Liver Fibrosis by Retinoid AntagonistPrincipal Investigator
- Principal Investigator
  
  OKUNO Masataka
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
レチノイドによる肝線維化抑制効果に関する研究Principal Investigator
- Principal Investigator
  
  奥野正隆
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
Study on the physiological and pathological significances of lipoprotein(a).
- Principal Investigator
  
  NOMA Akio
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Gifu University

All 2007 2006 2005 2004 2003

All Journal Article Book

[Book] Vitamins and the liver (A and D) : The Textbook of Hepatology.2007
- Author(s)
  Okuno, M. et al.
- Publisher
  Oxford, Blackwell Publishing. (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390215
[Book] Basic science to clinical practice(Section 2.3.11, Vitamins and the liver (A and D)., in The Textbook of Hepatology)2007
- Author(s)
  Okuno M. et al.
- Publisher
  Oxford, Blackwell Publishing(in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390215
[Book] Vitamins and the liver (A and D): Textbook of Hepatology. Dufour2007
- Author(s)
  Okuno, M., et. al.
- Publisher
  Oxford, Blackwell Publishing. (In press)
- Data Source
  KAKENHI-PROJECT-16390215
[Book] Vitamins and the liver (A and D): Textbook of Hepatology. Dufour2006
- Author(s)
  Okuno, M. et al.
- Publisher
  Oxford, Blackwell Publishing.(In press)
- Data Source
  KAKENHI-PROJECT-16390215
[Book] Current Cancer Drug Targets2004
- Author(s)
  Okuno M
- Total Pages
  14
- Publisher
  Bentham Science Publishers
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590585
[Journal Article] Prevention of rat hepatocarcinogenesis by acyclic retinoid is accompanied by reduction in emergence of both TNF-a-expressing oval-like cells and activated hepatic stellate cells2005
- Author(s)
  Sano T, Kagawa M, Okuno M, Ishibashi N, Hashimoto M, Yamamoto M, Suzuki R, Kohno H, Kojima S, Friedman SL, Moriwaki H, Tanaka T
- Journal Title
  
  Nutr Cancer 51
  
  Pages: 197-206
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590585
[Journal Article] Liver injury induced by lipopolysaccharide is mediated by TNFR-1 but not by TNFR-2 or Fas in mice2005
- Author(s)
  Shimizu S, Yamada Y, Okuno M, Ohnishi H, Osawa Y, Seishima M, Moriwaki H
- Journal Title
  
  Hepatol Res 31
  
  Pages: 136-142
- NAID
  10016478673
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590585
[Journal Article] Retinoids in cancer chemoprevention2004
- Author(s)
  Okuno M, Kojima S, Matsushima-Nishiwaki R.
- Journal Title
  
  Carrent Cancer Drug Therapy 4
  
  Pages: 285-298
- Data Source
  KAKENHI-PROJECT-16590585
[Journal Article] The RING finger protein, RNF8, interacts with retinoid X receptor α and enhances its transcription activity2004
- Author(s)
  Takano Y, Adachi S, Okuno M, et al.
- Journal Title
  
  J Biol Chem 279
  
  Pages: 18926-18934
- Data Source
  KAKENHI-PROJECT-16590585
[Journal Article] Retinoids in cancer chemoprevention.2004
- Author(s)
  Okuno M 他
- Journal Title
  
  Current Cancer Drug Therapy 4
  
  Pages: 285-298
- Data Source
  KAKENHI-PROJECT-13220007
[Journal Article] Acyclic retinoid, NIK-333, inhibits N-diethylnitrosamine-induced rat hepatocarcinogenesis through suppression of TGF-α2004
- Author(s)
  Kagawa M, Sano T, Ishibashi N, Okuno M, et al.
- Journal Title
  
  Carcinogenesis 25
  
  Pages: 979-985
- Data Source
  KAKENHI-PROJECT-16590585
[Journal Article] Acyclc retinoid, NIK-333, inhibits N-diethyl nitrosamine-induced rat hepatocarcinogenesis through suppression of TGF-α expression and cell proliferation2004
- Author(s)
  Kagawa M, Sano T, Ishibashi N, Hashimoto M, Okuno M, Moriwaki H, Suzuki R, Kohno H, Tanaka T
- Journal Title
  
  Carcinogenesis 25
  
  Pages: 979-985
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590585
[Journal Article] Retinoids in Cancer Chemoprevention.2004
- Author(s)
  Okuno, M. et al.
- Journal Title
  
  Current Cancer Drug Target. 4(3)
  
  Pages: 285-298
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390215
[Journal Article] Acyclic retinoid in the chemoprevention of hepatocellular carcinoma2004
- Author(s)
  Kojima S, Okuno M, Matsushima-Nishiwaki R
- Journal Title
  
  Int J Oncol 24
  
  Pages: 797-805
- Data Source
  KAKENHI-PROJECT-16590585
[Journal Article] Retinoids in cancer chemoprevention2004
- Author(s)
  Okuno M. et al.
- Journal Title
  
  Current Cancer Drug Target 4(3)
  
  Pages: 285-298
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390215
[Journal Article] The ring finger protein, RNF8, interacts with retinoid X receptor α and enhances its transcription-stimulating activity2004
- Author(s)
  Takano Y, Adachi S, Okuno M, Muto Y, Yoshioka T, Matsushima-Nishiwaki R, Tsurumi H, Ito K, Friedman SL, Moriwaki H, Kojima S, Okano Y
- Journal Title
  
  J Biol Chem 279
  
  Pages: 18926-18934
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590585
[Journal Article] Acyclic retinoid in the chemoprevention of hepatocellular carcinoma2004
- Author(s)
  Kojima S, Okuno M, Matsushima-Nishiwaki R, Friedman SL, Moriwaki H
- Journal Title
  
  Int J Oncol 24
  
  Pages: 797-805
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590585
[Journal Article] Molecular mechanism for growth suppression of human hepatocellular carcinoma cells by acyclic retinoid2003
- Author(s)
  Matsushima-Nishiwaki R, Okuno M, Takano Y, Kojima S, Friedman SL, Moriwaki H
- Journal Title
  
  Carcinogenesis 24
  
  Pages: 1353-1359
- NAID
  110002843034
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590585

1. MORIWAKI Hisataka (50174470)

# of Collaborated Projects: 7 results

# of Collaborated Products: 6 results
2. KJIMA Soichi (10202061)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. SHIDOJI Yoshihiro (00111518)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. OMORI Masahide (30278212)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SHIRATORI Yoshimune (20313877)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. NOMA Akio (30208384)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SEISHIMA Mitsuru (10171315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ABE Akira (30175898)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SHIMOKAWA Kuniyasu (70021376)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SUZUKI Yasuhiro (60332277)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SAIO Masanao (40242721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 岡野幸雄 (10177066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 原田実根 (00019621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 末岡尚子 (20321846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 山口研成 (10321845)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 中村容子 (90227950)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 牧野和彦 (80181618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 古谷裕 (80392108)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OKUNO Masataka 奥野 正隆

Research Projects

Research Products

Co-Researchers

Detection and regulation of hepatic diseases targeting TGF-β activation reaction.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of cytokine cascade in impaired liver regeneration and development of candidate pharmaceutical(s) to regulate this mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

核受容体蛋白を標的分子としたがん化学予防の研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Retinoid upregulates the sensitivity of cancer cells to a cytokine by inducing the cytokine receptor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Improvement of Hepatic fibrosis/cirrhosis and impaired liver regeneration using protease inhibitors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a drug that inhibit liver fibrosis by interfering with the signal transduction of TGF-βPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MECHANISMS OF CLONAL DELETION OF HEPATOCELLULAR CARCINOMA BY ACYCLICRETINOID

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Inhibition of Liver Fibrosis by Protease InhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MECHANISMS OF REGULATION AND CONTROL OF HEPATOCARCINOGENESIS BY ACYCLIC RETINOID

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Inhibition of Liver Fibrosis by Retinoid AntagonistPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

レチノイドによる肝線維化抑制効果に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the physiological and pathological significances of lipoprotein(a).

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Vitamins and the liver (A and D) : The Textbook of Hepatology.2007

Author(s)

Publisher

Description

OKUNO Masataka 奥野正隆