Iwamoto Ryo 岩本亮

… Alternative Names

岩本亮イワモトリヨウ

IWAMOTO Ryo 岩本亮

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Researcher Number	10213323
Other IDs
Affiliation (Current)	2025: 大阪大学, 微生物病研究所, 准教授
Affiliation (based on the past Project Information) *help	2012 – 2021: 大阪大学, 微生物病研究所, 准教授 2007 – 2010: Osaka University, Research Institute for Microbial Diseases, Associate Professor 2004 – 2006: Osaka University, Research Institute for Microbial Diseases, Assiociate Professor, 微生物病研究所, 助教授 2000 – 2004: Research Institute for Microbial Diseases, Osaka University, Instructor, 微生物病研究所, 講師 2003: 大阪大学, 講師 1991 – 1999: Institute of Life Science, Kureme University, Research Associate, 分子生命科学研究所, 助手
Review Section/Research Field	Principal Investigator Cell biology / Cell biology / Bacteriology (including Mycology) / Biological Sciences / Basic Section 44010:Cell biology-related Except Principal Investigator Cell biology / Biological Sciences / Tumor therapeutics / Cell biology / Bacteriology (including Mycology) / 細菌学
Keywords	Principal Investigator HB-EGF / 増殖因子 / ErbB / 細胞・組織 / CD9 / HSPG / EGFR / 細胞間情報伝達 / EGF受容体 / 膜結合型増殖因子 … More / ジャクスタクライン / ジフテリア毒素 / 心臓弁形成 / 増殖抑制 / ectodomain shedding / シグナル伝達 / 細胞増殖因子 / 細胞外マトリックス / 発生・分化 / ノックインマウス / protein kinase C / MDC9 / DRAP27 / Snail / Extracellular matrix / Intercellular signaling / インテグリンα3β1 / がん / がん増殖 / 形態形成 / Valvulogenesis / Cardiac valve / Growth-inhibition / knock-in mice / epidermal remodeling / valvulogenesis / cardiomyopathy / EGF family / 組織再生 / 表皮再生 / 心臓弁発生 / 心筋症 / EGFファミリー / エクトドメインシェディング / Knock-in mouse / EOF receptor / Signal Transduction / Growth Factor / ジーン・ターゲティング / ADAM family / cell-to-cell signalling / juxtacrine / EGFreceptor / 切断酵素 / エクトドメイン・シェディング / 細胞外環境 / ジフテリア心筋炎 / ジフテリア毒素受容体 / LPA / Ectodomain shedding / ジフテリア毒素リセプター / Integrinα3β1 / リセプター … More Except Principal Investigator HB-EGF / CD9 / インテグリン / ジフテリア毒素 / DRAP27 / 膜結合型細胞増殖因子 / ジャクスタクライン / 細胞増殖因子 / 細胞接着 / リセプター / LPA / CRM197 / ヘパラン硫酸プロテオグリカン / TM4ファミリー / ジフテリア毒素リセプター / エクトドメインシェディング / アポトーシス / ADAM / Ectodomain shedding / Transactivation / メタロプロテアーゼ / リゾフォスファチジン酸 / MAPキナーゼキナーゼ / プロテインキナーゼC / G蛋白共役型リセプター / トランスアクチベーション / 膜結合型 / Growth Factors / Cell adhesion / Integrin / diphtheria toxin / membrane-anchored growth factors / TM4 / integrin / juxtacrine / Fusion protein / Endonuclease / Xeroderma pigmentosum / Diphtheria toxin / フラグメントB / 色素性乾皮症 / EGFファミリー / EGFR / CD63 / 細胞外マトリックス / 膜通過 / エンドサイトーシス / 発現クローニング / マイコプラズマ / EGF受容体 / 増殖抑制 / ErbB4 / protease / ectodomain shedding / シグナル伝達 / プロテアーゼ / エクトドメインシェディン / ovarian cancer / growth factor / EGF family / 心不全 / p38MAPK / 遺伝子欠損マウス / 遺伝子ターゲッティング / 増殖因子 / 卵巣癌 / G-protein-coupled receptor / メタロプロデアーゼ / G-oritein-coupled receptors / エクトドメインシェヂング / heregulin / EGF receptor / 腫瘍増殖因子抑制物質 / EGFリセプター / heparansulfate proteoglycans / TPA / haparansulfate proteoglycans / FuragmentB / 融合蛋白 / エンドヌクレアーゼ / Genetic disorder / 融合蛋白質 / 遺伝子発現 / 遺伝病 / エンドヌクレア-ゼ / 増殖機構 / siRNA / 3次元環境 / 癌間質 / sHRNA / 腫瘍形成 / EGF / 3次元増殖 / 浸潤転移 / エミリン / 細胞間接着部位 / 細胞内局在 / ジャクスタクランイ機構 / プロテオグリカン / theta毒素 / V-ATPase / エンドソーム / バフィロマイシン / H^+-ATPase / 酸性化 / 複合体 / cDNAクロ-ニング / 膜タンパク質 / リセプタ- Less

Inhibition of cell proliferation by induction of HB-EGF-HSPG-ErbB4 signaling systemPrincipal Investigator
- Principal Investigator
  
  IWAMOTO Ryo
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Osaka University
Mechanism regulating cellular proliferation by HB-EGF-ErbB4 signaling and its applicationPrincipal Investigator
- Principal Investigator
  
  Iwamoto Ryo
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
Development of a novel anti-cancer therapeutics targeting HB-EGF
- Principal Investigator
  
  MEKADA EISUKE
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Osaka University
Regulatory mechanism that regulates ectodomain shedding of HB-EGF by ADAM17Principal Investigator
- Principal Investigator
  
  Iwamoto Ryo
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
Regulation of cell proliferation by HB-EGF in mouse cardiac valve developmentPrincipal Investigator
- Principal Investigator
  
  IWAMOTO Ryo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
ヘパラン硫酸プロテオグリカンによる増殖因子HB-EGFの生理活性制御機構の解明Principal Investigator
- Principal Investigator
  
  岩本亮
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Study of medianism for the cell growth inhibition by HB-EGF in cardiac valve developmentPrincipal Investigator
- Principal Investigator
  
  IWAMOTO Ryo
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
Cell function regulation by membrane-anchored growth factors
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Analysis of the ectodomain shedding mechanism of HB-EGF
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
Physiological role and the mechanism of the interaction between HB-EGF and HSPGPrincipal Investigator
- Principal Investigator
  
  IWAMOTO Ryo
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
Growth regulation mediated by EGF family of growth factors
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Physiological significance of proHB-EGF ectodomain shedding in epideimal developmentPrincipal Investigator
- Principal Investigator
  
  IWAMOTO Ryo
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
ジフテリア感染モデルマウスの作製とその発症機構の解析Principal Investigator
- Principal Investigator
  
  岩本亮
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Physiological function of HB-EGF : Study of the knock-in mice of the mutant form of HB-EGFPrincipal Investigator
- Principal Investigator
  
  IWAMOTO Ryo
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
膜結合型増殖因子proHB-EGFによるEGF受容体を介した情報伝達機構の解析Principal Investigator
- Principal Investigator
  
  岩本亮
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kurume University
The role and molecular mechanism of the ectodomain shedding of HB-EGF
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
  Kurume University
Conversion of membrane-anchored HB-EGF into the soluble form.
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
膜結合型増殖因子複合体によるジャクスタクライン機構の解析Principal Investigator
- Principal Investigator
  
  岩本亮
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kurume University
膜結合型細胞増殖因子による細胞接着を介した細胞増殖制御
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
The role of membrane-anchored HB-EGF on cell growth
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Cell biology
- Research Institution
  Kurume University
Juxtacrine Growth Control with HB-EGF Complex
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  Kurume University
Study of the activity of proHB-EGF complex.Principal Investigator
- Principal Investigator
  
  IWAMOTO Ryo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Institute of Life Science, Kurume University
膜結合型細胞増殖因子と細胞外マトリックスの相互作用によるシグナルの伝達
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
CD9ファミリーを介した膜結合型細胞増殖因子-細胞接着因子複合体の機能解析
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
ジフテリア毒素リセプター複合体の解析Principal Investigator
- Principal Investigator
  
  岩本亮
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kurume University
膜結合型細胞増殖因子と細胞外マトリックスの相互作用によるシグナルの伝達
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
膜タンパク質DRAP27を介した膜結合型細胞増殖因子と細胞接着因子のクロスリンク
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
膜結合型細胞増殖因子によるジャクスタクラインとそれに関与する膜蛋白質の解析Principal Investigator
- Principal Investigator
  
  岩本亮
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Cell biology
- Research Institution
  Kurume University
Analysis of the comprising membrane-anchored growth factor and cell adhesion molecule.
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  Kurume University
An attempt to form mutant CRM197 proteins of diphtheria toxin with neutralizing activity to heregulin.
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kurume University
膜結合型細胞増殖因子と細胞外マトリックスの相互作用によるシグナルの伝達
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
膜タンパク質DRAP27を介した膜結合型細胞増殖因子と細胞接着因子のクロスリング
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
膜結合型細胞増殖因子を介したジャクスタクラインにおけるDRAP27の機能解析
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Kurume University
ジフテリア毒素リセプターの機能をモジュレートする細胞側因子の解析Principal Investigator
- Principal Investigator
  
  岩本亮
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kurume University
Juxtacrine stimulation of cellular communication by HB-EGF.
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kurume University
ジフテリア毒素のエンドサイトーシス過程におけるDRAP27タンパク質の役割解析
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
細胞内酸性小胞からの毒素タンパク質の細胞内遊離機構の解析
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
膜結合型細胞増殖因子と細胞外マトリックスの相互作用によるシグナルの伝達
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
膜結合型細胞増殖因子HB-EGFの細胞膜上での発現を調節すタンパク質の解析
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Kurume University
ジフテリア毒素リセプター・アソシエ-ト蛋白質によるリセプター量上昇機構の解析Principal Investigator
- Principal Investigator
  
  岩本亮
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kurume University
ジフテリア毒素をモデルにした蛋白質の細胞内輸送機構の解析
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
バフィロンマイシンによるジフテリア毒素の細胞内輸送・分解機構の解析
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
膜蛋白質DRAP27のジフテリア毒素受容体および毒素の細胞内侵入における役割
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  細菌学
- Research Institution
  Kurume University
Sending regulatory elements into the nuclei from medium.
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kurume University
ジフテリア毒素をモデルにした蛋白質の細胞内輸送機構の解析
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
Sending regulatory elements into the nuelei of cells.
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kurume University

[Book] Encyclopedia of Signalling Molecules (HB-EGF (Heparin-binding EGF-Like Growth Factor))2012
- Author(s)
  Ryo Iwamoto, Eisuke Mekada
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-24570212
[Journal Article] Redundant roles of EGFR ligands in the ERK activation waves during collective cell migration2021
- Author(s)
  Shuhao Lin, Daiki Hirayama, Gembu Maryu, Kimiya Matsuda, Naoya Hino, Eriko Deguchi, Kazuhiro Aoki, Ryo Iwamoto, Kenta Terai, Michiyuki Matsuda
- Journal Title
  
  Life Science Alliance
  
  Volume: 5 Issue: 1 Pages: 1-13
- DOI
  10.26508/lsa.202101206
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06218, KAKENHI-PLANNED-19H05798, KAKENHI-PROJECT-19H00993, KAKENHI-PROJECT-20H03475, KAKENHI-PLANNED-20H05898, KAKENHI-PROJECT-23K21377
[Journal Article] BK-UM in patients with recurrent ovarian cancer or peritoneal cancer: a first-in-human phase-I study.2017
- Author(s)
  Miyamoto S, Yotsumoto F,他３０名、 Iwamoto R, Mekada E.
- Journal Title
  
  BMC Cancer.
  
  Volume: 17 Issue: 1 Pages: 89-97
- DOI
  10.1186/s12885-017-3071-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26250033, KAKENHI-PROJECT-26293362, KAKENHI-PROJECT-15K07046
[Journal Article] ErbB1 and ErbB4 generate opposing signals regulating mesenchymal cell proliferation during valvulogenesis.2017
- Author(s)
  Iwamoto R, Mine N, Mizushima H, Mekada E
- Journal Title
  
  J Cell Sci.
  
  Volume: 130 Issue: 7 Pages: 1321-1332
- DOI
  10.1242/jcs.196618
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26250033, KAKENHI-PROJECT-15K07046
[Journal Article] RNA Aptamer Binds Heparin-Binding Epidermal Growth Factor-Like Growth Factor with High Affinity and Specificity and Neutralizes Its Activity2017
- Author(s)
  Masaki Yamato, Tetsuo Minamino, yamato masaki, Takashi Matsuzaki, Ryo Araki, Shota Tsuchida, Keiji Okuda, Hai Ying Fu, Shoji Sanada, Hiroshi Asanuma, Yoshihiro Asano, Masanori Asakura, Hiroomi Torii, Kentaro Noi, Hirotsugu Ogi, Ryo Iwamoto, Eisuke Mekada, Seiji Takashima, Yasushi Sakata, Masafumi Kitakaze
- Journal Title
  
  Int. J. Gerontol.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07046
[Journal Article] RNA Aptamer Binds Heparin-Binding Epidermal Growth Factor-Like Growth Factor with High Affinity and Specificity and Neutralizes Its Activity.2017
- Author(s)
  Masaki Yamato, Tetsuo Minamino, yamato masaki, Takashi Matsuzaki, Ryo Araki, Shota Tsuchida, Keiji Okuda, Hai Ying Fu, Shoji Sanada, Hiroshi Asanuma, Yoshihiro Asano, Masanori Asakura, Hiroomi Torii, Kentaro Noi, Hirotsugu Ogi, Ryo Iwamoto, Eisuke Mekada, Seiji Takashima, Yasushi Sakata, Masafumi Kitakaze
- Journal Title
  
  Int. J. Gerontol.
  
  Volume: 11 Issue: 3 Pages: 191-196
- DOI
  10.1016/j.ijge.2017.03.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07046, KAKENHI-PROJECT-15H03587
[Journal Article] Characterization of a novel anti-human HB-EGF monoclonal antibody applicable for paraffin-embedded tissues and diagnosis of HB-EGF-related cancers.2016
- Author(s)
  Iwamoto,R., Takagi, M., Akatsuka, J., Ono, K., Kishi, Y., and Mekada, E.
- Journal Title
  
  Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
  
  Volume: 35 Issue: 2 Pages: 1-10
- DOI
  10.1089/mab.2015.0062
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07046, KAKENHI-PROJECT-24570212, KAKENHI-PROJECT-26250033
[Journal Article] Identification of diphtheria toxin R domain mutants with enhanced inhibitory activity against HB-EGF2015
- Author(s)
  Suzuki K, Mizushima H, Abe H, Iwamoto R, Nakamura H, Mekada E
- Journal Title
  
  J Biochem
  
  Volume: mvu079 Issue: 5 Pages: 331-343
- DOI
  10.1093/jb/mvu079
- NAID
  40020461422
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23570227, KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118008, KAKENHI-PROJECT-26460525, KAKENHI-PROJECT-15K07046, KAKENHI-PROJECT-24570212, KAKENHI-PROJECT-26250033
[Journal Article] Metastasis Suppressor Tetraspanin CD82/KAI1 Regulates Ubiquitylation of Epidermal Growth Factor Receptor.2013
- Author(s)
  Odintsova E, van Niel G, Conjeaud H, Raposo G, Iwamoto R, Mekada E, Berditchevski F.
- Journal Title
  
  J Biol Chem.
  
  Volume: 288 Issue: 36 Pages: 26323-26334
- DOI
  10.1074/jbc.m112.439380
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23240126, KAKENHI-PROJECT-24570212
[Journal Article] Conditional loss of heparin-binding EGF-like growth factor results in enhanced liver fibrosis after bile duct ligation in mice.2013
- Author(s)
  Takemura T, Yoshida Y, Kiso S, Kizu T, Furuta K, Ezaki H, Hamano M, Egawa M, Chatani N, Kamada Y, Imai Y, Higashiyama S, Iwamoto R, Mekada E, Takehara T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 437 Issue: 2 Pages: 185-191
- DOI
  10.1016/j.bbrc.2013.05.097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240126, KAKENHI-PROJECT-23590974, KAKENHI-PROJECT-24390074, KAKENHI-PROJECT-24570212, KAKENHI-PROJECT-24590972, KAKENHI-PROJECT-24590975
[Journal Article] Conditional knockout of heparin-binding epidermal growth factor-like growth factor in the liver accelerates carbon tetrachloride-induced liver injury in mice.2012
- Author(s)
  Takemura, T., YoshidaY., Kiso, S., Saji, Y., Ezaki, H., Hamano, M., Kizu, T., Egawa, M., Chatani, N., Furuta, K., Kamada, Y., Iwamoto, R., Mekada, E., Higashiyama, S., Hayashi, N. and Takehara, T.
- Journal Title
  
  Hepatol Res
  
  Volume: 43 Issue: 4 Pages: 384-393
- DOI
  10.1111/j.1872-034x.2012.01074.x
- NAID
  10031194550
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240126, KAKENHI-PROJECT-23590974, KAKENHI-PROJECT-24570212, KAKENHI-PROJECT-24590972
[Journal Article] Membrane type 1-matrix metalloproteinase cleaves off the NH2-terminal portion of heparin-binding epidermal growth factor and converts it into a heparin-independent growth factor.2010
- Author(s)
  Koshikawa, N., Mizushima, H., Minegishi, T., Iwamoto R., Mekada, E., Seiki, M.
- Journal Title
  
  Cancer Res. 70
  
  Pages: 6093-6103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570183
[Journal Article] HB-EGF function in cardiac valve development requires interaction with heparan sulfate proteoglycans.2010
- Author(s)
  Iwamoto, R., et al.
- Journal Title
  
  Development
  
  Volume: 137 Pages: 2205-2214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570183
[Journal Article] HB-EGF function in cardiac valve development requires interaction with heparan sulfate proteoglycans.2010
- Author(s)
  Iwamoto,R., Mine,N., Kawaguchi,T., Minami,S., Saeki,K., Mekada,E.
- Journal Title
  
  Development 137
  
  Pages: 2205-2214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Anti-human HB-EGF monoclonal antibodies inhibiting ectodomain shedding of HB-EGF and diphtheria toxin binding.2010
- Author(s)
  Hamaoka,M., Chinen,I., Murata,T., Takashima,S., Iwamoto,R., Mekada,E.
- Journal Title
  
  J. Biochem. 148
  
  Pages: 55-69
- NAID
  10027877136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Humanized gene replacement in mice reveals the contribution of cancer stroma-derived HB-EGF to tumor growth.2010
- Author(s)
  Ichise, T., Adachi, S., Ohishi, M., Ikawa, M., Okabe, M., Iwamoto R., Mekada, E.
- Journal Title
  
  Cell Struct. Funct. 35
  
  Pages: 3-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570183
[Journal Article] Humanized Gene Replacement in Mice Reveals the Contribution of Cancer Stroma-Derived HB-EGF to Tumor Growth.2010
- Author(s)
  Ichise T, Adachi S, Ohishi M, Ikawa M, Okabe M, Iwamoto R, Mekada E.
- Journal Title
  
  Cell Struct Funct.
  
  Volume: 35 Pages: 3-13
- NAID
  130004137552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Humanized Gene Replacement in Mice Reveals the Contribution of Cancer Stroma-Derived HB-EGF to Tumor Growth.2010
- Author(s)
  Ichise,T., Adachi,S., Ohishi,M., Ikawa,M., Okabe,M., Iwamoto,R., Mekada,E.
- Journal Title
  
  Cell Struct Funct. 35
  
  Pages: 3-13
- NAID
  130004137552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] MT1-MMP cleaves off the NH2-terminal portion of HB-EGF and converts it into a heparin -independent growth factor.2010
- Author(s)
  Koshikawa,N., Mizushima,H., Minegishi,T., Iwamoto,R., Mekada,E. Seiki,M
- Journal Title
  
  Cancer Res. 70
  
  Pages: 6093-6103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] HB-EGF function in cardiac valve development requires interaction with heparan sulfate proteoglycans.2010
- Author(s)
  Iwamoto R.^*, Mine, N., Kawaguchi, T., Minami, S., Saeki, K., Mekada, E.(^*corresponding author)
- Journal Title
  
  Development 137
  
  Pages: 2205-2214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570183
[Journal Article] Humanized Gene Replacement in Mice Reveals the Contribution of Cancer Stroma-Derived HB-EGF to Tumor Growth.2010
- Author(s)
  Ichise T, Adachi S, Ohishi M, Ikawa M, Okabe M, Iwamoto R, Mekada E.
- Journal Title
  
  Cell Struct Funct. 35
  
  Pages: 3-13
- NAID
  130004137552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Anti-human HB-EGF monoclonal antibodies inhibiting ectodomain shedding of HB-EGF and diphtheria toxin binding.2010
- Author(s)
  Hamaoka, M., Chinen, I., Murata, T., Takashima, S., Iwamoto R., Mekada, E.
- Journal Title
  
  J.Biochem. 148
  
  Pages: 55-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570183
[Journal Article] HB-EGFにおけるシェディングの役割とその制御2009
- Author(s)
  岩本亮
- Journal Title
  
  蛋白質核酸酵素 54
  
  Pages: 1722-1727
- Data Source
  KAKENHI-PROJECT-20570183
[Journal Article] HB-EGFにおけるシェディングの役割とその制御2009
- Author(s)
  岩本亮
- Journal Title
  
  蛋白質核酸酵 54(13)
  
  Pages: 1722-1727
- Data Source
  KAKENHI-PROJECT-20570183
[Journal Article] HB-EGF2008
- Author(s)
  Mekada, E., Iwamoto, R.
- Journal Title
  
  UCSD-Nature Molecular Pages(on line) doi : 10. 1038/mp. a002932. 01
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570183
[Journal Article] HB-EGF decelerates cell proliferation synergistically with TGF-・in perinatal distal lung development.2008
- Author(s)
  Minami, S., Iwamoto, R., Mekada, E.
- Journal Title
  
  Dev.Dyn. 237
  
  Pages: 247-258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] HB-EGF decelerates cell proliferation synergistically with TGFα in perinatal distal lung development2008
- Author(s)
  Minami, S., Iwamoto R.^*, Mekada, E.(^*corresponding author)
- Journal Title
  
  Dev.Dyn. 237
  
  Pages: 247-258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570183
[Journal Article] 細胞外マトリックスにおけるヘパラン硫酸プロテオグリカンによるシグナル分子の制御2008
- Author(s)
  岩本亮
- Journal Title
  
  生体の科学 59
  
  Pages: 340-341
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570183
[Journal Article] HB-EGF decelerates cell proliferation synergistically with TGF-a in perinatal distal lung development.2008
- Author(s)
  Minami,S., Iwamoto,R., Mekada,E
- Journal Title
  
  Dev. Dyn. 237
  
  Pages: 247-258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] 細胞外マトリックスにおけるヘパラン硫酸プロテオグリカンによるシグナル分子の制御2008
- Author(s)
  岩本亮
- Journal Title
  
  生体の科学 59(5)
  
  Pages: 340-341
- Data Source
  KAKENHI-PROJECT-20570183
[Journal Article] HB-EGF. UCSD-Nature Molecule Pages.2008
- Author(s)
  Mekada,E., Iwamoto,R.
- Journal Title
  
  Published online 13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] HB-EGF2008
- Author(s)
  Mekada, E., Iwamoto R.
- Journal Title
  
  UCSD-Nature Molecule Pages.(doi:10.1038/mp.a002932.01)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570183
[Journal Article] Maternal heparin-binding-EGF deficiency limits pregnancy success in mice.2007
- Author(s)
  Xie,H., Wang,H., Tranguch,S., Iwamoto,R., Mekada,E., DeMayo F.J., Lydon,J.P., Das,S.K., Dey,S.K
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 104
  
  Pages: 18315-18320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Diphtheria toxin mutant CRM197 possesses weak EF2-ADP-ribosyl activity that potentiates its anti-tumorigenic activity.2007
- Author(s)
  Kageyama,T., Ohishi,M., Miyamoto,S., Mizushima,H., Iwamoto,R. Mekada,E
- Journal Title
  
  J.Biochem. 142
  
  Pages: 95-104
- NAID
  10020098014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] ErbB and HB-EGF signaling in heart development and function.2006
- Author(s)
  Iwamoto, R., et. al.
- Journal Title
  
  Cell Struct.Funct. 31
  
  Pages: 1-14
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18570176
[Journal Article] ErbB and HB-EGF signaling in heart development and function.2006
- Author(s)
  Iwamoto, R., Mekada, E.
- Journal Title
  
  Cell Struct. Funct. 31
  
  Pages: 1-14
- Data Source
  KAKENHI-PROJECT-18060028
[Journal Article] Cytoplasmic domain phosphorylation of heparin-binding EGF-like growth factor.2006
- Author(s)
  Wang, X., Mizushima, H., Adachi, S., Ohishi, M., Iwamoto, R., Mekada, E.
- Journal Title
  
  Cell Structure and Function (In press)
- Data Source
  KAKENHI-PROJECT-16570159
[Journal Article] Cytoplasmic Domain Phosphorylation of Heparin-Binding EGF-like Growth Factor.2006
- Author(s)
  Wang, X., Mizushima, H., Adachi, S., Oishi, M., Iwamoto, R., Mekada, E.
- Journal Title
  
  Cell Struct.Funct. (in press)
- NAID
  130004053854
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] ErbB and HB-EGF signaling in heart development and function.2006
- Author(s)
  Iwamoto,R. Mekada,E
- Journal Title
  
  Cell Struct. Funct. 31
  
  Pages: 1-14
- NAID
  130004137503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] ErbB and HB-EGF signaling in heart development and function2006
- Author(s)
  Iwamoto, R., et. al.
- Journal Title
  
  Cell Struct. Funct 31
  
  Pages: 1-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570176
[Journal Article] Cytoplasmic Domain Phosphorylation of Heparin-Binding EGF-like Growth Factor.2006
- Author(s)
  Wang,X., Mizushima,H., Adachi,S., Ohishi,M., Iwamoto,R., Mekada,E.
- Journal Title
  
  Cell Struct. Funct. 31
  
  Pages: 15-27
- NAID
  130004053854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Cytoplasmic Domain Phosphorylation of Heparin-Binding EGF-like Growth Factor.2006
- Author(s)
  Wang, X., Mizushima, H., Adachi, S., Oishi, M., Iwamoto, R., Mekada, E.
- Journal Title
  
  Cell Struct.Funct. (in press.)
- NAID
  130004053854
- Data Source
  KAKENHI-PROJECT-16207014
[Journal Article] ErbB and HB-EGF signaling in heart development and function.2006
- Author(s)
  Iwamoto, R. et al.
- Journal Title
  
  Cell Struct.Funct. 31
  
  Pages: 1-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570159
[Journal Article] ErbB and HB-EGF signaling in heart development and function.2006
- Author(s)
  Iwamoto, R., Mekada, E.
- Journal Title
  
  Cell Struct. Funct. 31
  
  Pages: 1-14
- NAID
  130004137503
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Cytoplasmic Domain Phosphorylation of Heparon-Binding EGF-like Growth Factor.2006
- Author(s)
  Wang, X., Mizushima, H., Adachi, S., Ohishi, M., Iwamoto, R., Mekada,E.
- Journal Title
  
  Cell Struct.Funct. 31
  
  Pages: 15-27
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] ErbB and HB-EGF signaling in heart development and function.2006
- Author(s)
  Iwamoto, R., Mekada, E.
- Journal Title
  
  Cell Structure and Function 31
  
  Pages: 1-14
- Data Source
  KAKENHI-PROJECT-16570159
[Journal Article] ErbB and HB-EGF signaling in heart development and function.2006
- Author(s)
  Iwamoto, R., Mekada, E.
- Journal Title
  
  Cell Struct. Funct. 31
  
  Pages: 1-14
- Data Source
  KAKENHI-PROJECT-18570176
[Journal Article] HB-EGF promotes epithelial cell migration in eyelid development.2005
- Author(s)
  Mine, N., Iwamoto, R., Mekada, E.
- Journal Title
  
  Development 132
  
  Pages: 4317-4326
- Data Source
  KAKENHI-PROJECT-16207014
[Journal Article] Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing.2005
- Author(s)
  Shirakata, Y., Kimura, K., Nanba, D., Iwamoto, R., Tokumaru, S., Morimoto, C., Yokota, K., Nakamura, M., Sayama, K., Mekada, E., Higashiyama, S., Hashimoto, K.
- Journal Title
  
  J.Cell Sci. 118
  
  Pages: 2363-2370
- Data Source
  KAKENHI-PROJECT-16207014
[Journal Article] HB-EGF promotes epithelial cell migration in eyelid development.2005
- Author(s)
  Mine, N., Iwamoto, R., Mekada, E.
- Journal Title
  
  Development 132
  
  Pages: 4317-4326
- Data Source
  KAKENHI-PROJECT-16570159
[Journal Article] Clinical significance of heparin-binding epidermal growth factor-Like growth factor in peritoneal fluid of ovarian cancer.2005
- Author(s)
  Yagi, H., Miyamoto, S., Tanaka, Y., Sonoda, K., Kobayashi, H., Kishikawa, T., Iwamoto, R., Mekada, E., Nakano, H.
- Journal Title
  
  Brit.J.Cancer 92
  
  Pages: 1737-1745
- Data Source
  KAKENHI-PROJECT-16207014
[Journal Article] HB-EGF promotes epithelial cell migration in eyelid development.2005
- Author(s)
  Mine,N., Iwamoto,R. Mekada,E.
- Journal Title
  
  Development 132
  
  Pages: 4317-4326
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing.2005
- Author(s)
  Shirakata, Y., Kimura, K., Nanba, D., Iwamoto, R., Tokumaru, S., Morimoto, C., Yokota, K., Nakamura, M., Sayama, K., Mekada, E., Higashiyama, S., Hashimoto.K.
- Journal Title
  
  J.Cell Sci. 118
  
  Pages: 2363-2370
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Clinical significance of heparin-binding epidermal growth factor-like growth factor in peritoneal fluid of ovarian cancer.2005
- Author(s)
  Yagi, H., Miyamoto, S., Tanaka, Y., Sonoda, K., Kobayashi, H., Kishikawa, T., Iwamoto, R., Mekada, E., Nakano, H.
- Journal Title
  
  British Journal of Cancer 92
  
  Pages: 1737-1745
- Data Source
  KAKENHI-PROJECT-16570159
[Journal Article] HB-EGF promotes epithelial cell migration in eyelid development.2005
- Author(s)
  Mine, N., Iwamoto, R., Mekada, E.
- Journal Title
  
  Development 132
  
  Pages: 4317-4326
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Soluble form of heparin-binding EGF-like growth factor contributes to retinoic acid-induced epidermal hyperplasia.2005
- Author(s)
  Kimura, R., Iwamoto, R., Mekada, E.
- Journal Title
  
  Cell Structure and Function 30
  
  Pages: 35-42
- Data Source
  KAKENHI-PROJECT-16570159
[Journal Article] Soluble form of heparin-binding EGF-like growth facto contributes to retinoic acid-induced epidermal hyperplasia.2005
- Author(s)
  Kimura.R., Iwamoto, R., Mekada, E.
- Journal Title
  
  Cell Struct.Funct. 30
  
  Pages: 35-42
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Soluble form of heparin-binding EGF-like growth factor contributes to retinoic acid-induced epidermal hyperplasia.2005
- Author(s)
  Kinmura, R., Iwamoto, R., Mekada, E.
- Journal Title
  
  Cell Struct.Funct. 30
  
  Pages: 35-42
- NAID
  130004137496
- Data Source
  KAKENHI-PROJECT-16207014
[Journal Article] Clinical significance of heparin-binding epidermal growth factor-Like growth factor in peritoneal fluid of ovarian cancer.2005
- Author(s)
  Yagi, H., Miyamoto, S., Tanaka, Y., Sonoda, K., Kobayashi, H., Kishikawa, T., Iwamoto, R., Mekada, E., Nakano, H.
- Journal Title
  
  Brit.J.Cancer 92
  
  Pages: 1737-1745
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] HB-EGF and ErbB signaling is essential for heart function.2003
- Author(s)
  Iwamoto, R., et al.
- Journal Title
  
  Proc. Natl. Acad. Sci. U.S.A. 100
  
  Pages: 3221-3225
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14032202
[Patent] ヘパリン結合上皮細胞増殖因子様増殖因子に結合するモノクローナル抗体2006
- Inventor(s)
  目加田英輔、岩本亮、宮本新吾、設楽研也、古谷安希子、高橋久美子
- Industrial Property Rights Holder
  大阪大学、福岡大学、協和発酵株式会社
- Industrial Property Number
  2006-157279
- Filing Date
  2006-06-06
- Data Source
  KAKENHI-PROJECT-17014057
[Patent] 分泌型ヘパリン結合上皮細胞増殖因子様増殖因子の測定方法2006
- Inventor(s)
  目加田英輔、岩本亮、宮本新吾、設楽研也、古谷安希子
- Industrial Property Rights Holder
  大阪大学、福岡大学、協和発酵株式会社
- Industrial Property Number
  2006-157278
- Filing Date
  2006-06-06
- Data Source
  KAKENHI-PROJECT-17014057
[Presentation] Regulation of cell proliferation by HB-EGF-ErbB signaling in cardiac valve development2016
- Author(s)
  岩本亮
- Organizer
  第６８回日本細胞生物学会大会
- Place of Presentation
  京都テルサ
- Year and Date
  2016-06-13
- Data Source
  KAKENHI-PROJECT-15K07046
[Presentation] Physiological functions of diphtheria toxin receptor/HB-EGF2015
- Author(s)
  Ryo Iwamoto
- Organizer
  17th Europian Workshop on Bacterial Protein Toxins
- Place of Presentation
  Braga, Portugal
- Year and Date
  2015-06-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07046
[Presentation] Physiological functions of diphtheria toxin receptor/HB-EGF.2015
- Author(s)
  Ryo Iwamoto
- Organizer
  17th Europian Workshop on Bacterial Protein Toxins
- Place of Presentation
  Braga, Portugal
- Year and Date
  2015-06-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24570212
[Presentation] 破骨細胞分化過程におけるHB-EGF細胞質内領域の機能2014
- Author(s)
  中村尚志、岩本亮、目加田英輔
- Organizer
  第66回日本細胞生物学会大会
- Place of Presentation
  奈良
- Year and Date
  2014-06-11
- Data Source
  KAKENHI-PROJECT-26250033
[Presentation] 心臓弁形成におけるHB-EGF-EｒｂBシグナルによる細胞増殖制御2014
- Author(s)
  岩本亮、目加田英輔
- Organizer
  第66回日本細胞生物学会大会
- Place of Presentation
  奈良
- Year and Date
  2014-06-11
- Data Source
  KAKENHI-PROJECT-26250033
[Presentation] 心臓弁形成におけるHB-EGF-EGFRシグナルによる細胞増殖制御2013
- Author(s)
  岩本亮、沼田雄基、目加田英輔
- Organizer
  第６５回日本細胞生物学会大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24570212
[Presentation] C-terminal fragment of HB-EGF negatively regulates osteoclast differentiation2012
- Author(s)
  中村尚志、佐藤みずほ、北川教弘、岩本亮、目加田英輔
- Organizer
  第４５回日本発生生物学会・第６４回日本細胞生物学会合同大会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-24570212
[Presentation] Physiological functions of diphtheria toxin receptor/HB-EGF2010
- Author(s)
  岩本亮
- Organizer
  International Symposium on Organelle Network : Microbiology, Immunology, and Cell Biology
- Place of Presentation
  大阪(大阪国際会議場)(招待講演)
- Year and Date
  2010-07-13
- Data Source
  KAKENHI-PROJECT-20570183
[Presentation] 心臓弁形成におけるヘパラン硫酸プロテオグリカンによるHB-EGFの機能制御2010
- Author(s)
  岩本亮
- Organizer
  第62回日本細胞生物学会大会(招待講演)
- Place of Presentation
  大阪(大阪国際会議場)
- Year and Date
  2010-05-19
- Data Source
  KAKENHI-PROJECT-20570183
[Presentation] Role of ectodomain shedding in physiological functions of HB-EGF.2010
- Author(s)
  岩本亮
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会合同大会(招待講演)
- Place of Presentation
  神戸(神戸ポートアイランド)
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-20570183
[Presentation] Role of ectodomain shedding in physiological functions of HB-EGF2010
- Author(s)
  岩本亮
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸(神戸ポートアイランド)(招待講演)
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-20570183
[Presentation] 心臓弁形成におけるヘパラン硫酸プロテオグリカンによるHB-EGFの機能制御2010
- Author(s)
  岩本亮
- Organizer
  第62回日本細胞生物学会大会
- Place of Presentation
  大阪(大阪国際会議場)(招待講演)
- Year and Date
  2010-05-19
- Data Source
  KAKENHI-PROJECT-20570183
[Presentation] Physiological functions of diphtheria toxin receptor/HB-EGF.2010
- Author(s)
  岩本亮
- Organizer
  International Symposium on Organelle Network : Microbiology, lmmunology, and Cell Biology(招待講演)
- Place of Presentation
  大阪(大阪国際会議場)
- Year and Date
  2010-07-13
- Data Source
  KAKENHI-PROJECT-20570183
[Presentation] HB-EGFとヘパラン硫酸プロテオグリカンの相互作用は正常な心臓弁形成に必須である2009
- Author(s)
  岩本亮
- Organizer
  第61回日本細胞生物学会大会
- Place of Presentation
  名古屋 (名古屋国際会議場)
- Year and Date
  2009-06-02
- Data Source
  KAKENHI-PROJECT-20570183
[Presentation] HB-EGFとヘパラン硫酸プロテオグリカンの相互作用は正常な心臓弁形成に必須である2009
- Author(s)
  岩本亮
- Organizer
  第61回日本細胞生物学会大会
- Place of Presentation
  名古屋(名古屋国際会議場)
- Year and Date
  2009-06-02
- Data Source
  KAKENHI-PROJECT-20570183
[Presentation] HB-EGFの生理機能発揮におけるエクトドメイン・シェディングの役割2008
- Author(s)
  岩本亮
- Organizer
  第60回日本細胞生物学会大会(招待講演)
- Place of Presentation
  横浜(パシフィコ横浜)
- Year and Date
  2008-06-29
- Data Source
  KAKENHI-PROJECT-20570183
[Presentation] HB-EGFの生理機能発揮におけるエクトドメイン・シェディングの役割2008
- Author(s)
  岩本亮、目加田英輔
- Organizer
  第60回日本細胞生物学会大会
- Place of Presentation
  横浜
- Year and Date
  2008-06-29
- Data Source
  KAKENHI-PROJECT-17014057
[Presentation] HB-EGFの生理機能発揮におけるエクトドメイン・シェデイングの役割2008
- Author(s)
  岩本亮
- Organizer
  第60回日本細胞生物学会大会
- Place of Presentation
  横浜(パシフイコ横浜)
- Year and Date
  2008-06-29
- Data Source
  KAKENHI-PROJECT-20570183
[Presentation] Regulation of HB-EGF function by HSPGs.2007
- Author(s)
  岩本亮
- Organizer
  第40回日本発生生物学会・第59回日本細胞生物学会合同大会
- Place of Presentation
  福岡(福岡国際会議場)
- Year and Date
  2007-05-29
- Data Source
  KAKENHI-PROJECT-18060028
[Presentation] Regulation of HB-EGF function by HSPGs2007
- Author(s)
  Iwamoto, R
- Organizer
  JSDB-JSCB 2007
- Place of Presentation
  Fukuoka
- Year and Date
  2007-05-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570176
[Presentation] Regulation of HB-EGF function by HSPGs.2007
- Author(s)
  岩本亮
- Organizer
  第40回日本発生生物学会・第59回日本細胞生物学会合同大会
- Place of Presentation
  福岡(福岡国際会議場)
- Year and Date
  2007-05-29
- Data Source
  KAKENHI-PROJECT-18570176
[Presentation] Regulation of HB-EGF function by HSPGs.2007
- Author(s)
  岩本亮
- Organizer
  第40回日本発生生物学会・第59回日本細胞生物学会合同大会
- Place of Presentation
  福岡
- Year and Date
  2007-05-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18570176
[Presentation] Regulation of HB-EGFfunction by HSPGs2007
- Author(s)
  岩本亮、目加田英輔
- Organizer
  第40回日本発生生物学会・第59回日本細胞生物学会合同大会
- Place of Presentation
  福岡
- Year and Date
  2007-05-29
- Data Source
  KAKENHI-PROJECT-17014057
[Presentation] Interaction of HB-EGF with heparan sulfate proteoglycans is required for normal cardiac valve development.2007
- Author(s)
  Iwamoto, R.
- Organizer
  The 1^st Thailand-Japan Joint Forum on Infectious Diseases, Bangkok
- Year and Date
  2007-01-30
- Data Source
  KAKENHI-PROJECT-17014057
[Presentation] 骨のリモデリング制御因子としてのHB-EGFの役割2007
- Author(s)
  中村尚志、吉本晃正、戸井田英俊、小川拓哉、北川(石田)教弘、岩本亮、目加田英輔、竹家達夫
- Organizer
  第30回日本分子生物学会・第80回日本生化学会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17014057
[Presentation] ErbB signaling in cartilage and bone development.2006
- Author(s)
  Dealy,C.N., Fisher,M., Omi,M., Seghatoleslami,M.R., Clinton,G.M., Maihle,N.J., Iwamoto,R., Mekada,E., Mine,N.
- Organizer
  9^<th> International Conference on Limb Development and Regeneration, Awaji
- Year and Date
  2006-07-26
- Data Source
  KAKENHI-PROJECT-17014057
[Presentation] Regulation of HB-EGF function by heparan sulfate proteoglycans2006
- Author(s)
  Iwamoto, R
- Organizer
  MBSJ Forum 2006
- Place of Presentation
  Nagoya
- Year and Date
  2006-12-06
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570176
[Presentation] ヘパラン硫酸プロテオグリカンによる増殖因子HB-EGFの生理機能制御2006
- Author(s)
  岩本亮、目加田英輔
- Organizer
  日本分子生物学会2006フォーラム
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-17014057
[Presentation] ヘパラン硫酸プロテオグリカンによる増殖因子HB-EGFの生理機能制御2006
- Author(s)
  岩本亮
- Organizer
  日本分子生物学会2006フォーラム
- Place of Presentation
  名古屋
- Year and Date
  2006-12-06
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18570176
[Presentation] HB-EGF promotes epithelial cell migration in eyelid development.2005
- Author(s)
  Mine,N., Iwamoto,R., Mekada,E.
- Organizer
  The 45^th Annual Meeting of The American Society for Cell Biology, San Francisco
- Year and Date
  2005-12-13
- Data Source
  KAKENHI-PROJECT-17014057
[Presentation] 心臓弁形成におけるHB-EGF-ErbBシグナルによる細胞増殖制御
- Author(s)
  岩本亮、目加田英輔
- Organizer
  第６６回日本細胞生物学会大会
- Place of Presentation
  奈良
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-24570212

1. MEKADA Eisuke (20135742)

# of Collaborated Projects: 32 results

# of Collaborated Products: 40 results
2. TSUNEOKA Makoto (50197745)

# of Collaborated Projects: 20 results

# of Collaborated Products: 0 results
3. UMATA Toshiyuki (30213482)

# of Collaborated Projects: 17 results

# of Collaborated Products: 0 results
4. MITAMURA Toshihide (80268846)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
5. MIZUSHIMA Hiroto (30379094)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
6. NAKAMURA Kuniaki (70311305)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
7. MIYADO Kenji (60324844)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. YONEDA Yoshihiro (80191667)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. SEKIGUCHI Kiyotoshi (50187845)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. MURPHY Johon

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. KLAGSBRUN Michael

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. ASANO Shiro (00397613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. YAMAIZUMI Masaru (70107093)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. HIGASHIYAMA Shigeki (60202272)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NAKAMURA Takashi (00570673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 小戝健一郎 (90258418)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 山田源 (80174712)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. YONEDA Tomoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. JOHON R.Murp

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. MICHAEL Klag

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Iwamoto Ryo 岩本 亮

岩本 亮 イワモト リヨウ

IWAMOTO Ryo 岩本 亮

Research Projects

Research Products

Co-Researchers

Inhibition of cell proliferation by induction of HB-EGF-HSPG-ErbB4 signaling systemPrincipal Investigator

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Mechanism regulating cellular proliferation by HB-EGF-ErbB4 signaling and its applicationPrincipal Investigator

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Regulatory mechanism that regulates ectodomain shedding of HB-EGF by ADAM17Principal Investigator

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Regulation of cell proliferation by HB-EGF in mouse cardiac valve developmentPrincipal Investigator

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ヘパラン硫酸プロテオグリカンによる増殖因子HB-EGFの生理活性制御機構の解明Principal Investigator

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Study of medianism for the cell growth inhibition by HB-EGF in cardiac valve developmentPrincipal Investigator

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Physiological role and the mechanism of the interaction between HB-EGF and HSPGPrincipal Investigator

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Physiological significance of proHB-EGF ectodomain shedding in epideimal developmentPrincipal Investigator

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ジフテリア感染モデルマウスの作製とその発症機構の解析Principal Investigator

Principal Investigator

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Iwamoto Ryo 岩本亮

岩本亮イワモトリヨウ

IWAMOTO Ryo 岩本亮