Ohkubo Kimihiro 大久保公裕

… Alternative Names

OKUBO KIMIHIRO 大久保公裕

OHKUBO Kimihiro 大久保公裕

大久保公裕オオクボキミヒロ

OKUBO Kimihiro 大久保公裕

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Researcher Number	10213654
Other IDs	https://orcid.org/0000-0001-6757-3514
External Links
Affiliation (Current)	2025: 日本医科大学, 大学院医学研究科, 大学院教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 日本医科大学, 大学院医学研究科, 大学院教授 2017: 日本医科大学, 医学部, 助教授 2016: 日本医科大学, 大学院医学研究科, 大学院教授 2014 – 2015: 日本医科大学, 医学(系)研究科(研究院), 教授 2012: 日本医科大学, 医学(系)研究科 (研究院), 教授 … More 2012: 日本医科大学, 医学(系)研究科(研究院), 教授 2011: 日本医科大学, 大学院・医学研究科, 教授 2007 – 2008: 日本医科大学, 医学部, 准教授 2006: 日本医科大学, 医学部, 助教授 2002 – 2004: 日本医科大学, 医学部, 助教授 1993 – 1996: 日本医科大学, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related Except Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology / Basic Section 90140:Medical technology assessment-related
Keywords	Principal Investigator 花粉症 / アレルギー性鼻炎 / GM-CSF / IL-8 / IL-6 / 免疫療法 / モデル動物 / アジュバント / 〇スギ花粉症 / バイオマーカー … More / アレルゲン免疫療法 / スギ花粉症 / pollinosis / allergen challenge / airway hyper-reactivity / allergic rhinitis / substance P / neuropeptide / 神経ペプチド分解酵素 / ニュートラルエンドペプチデース / 鼻アレルギー / 好酸球 / 気道過敏性亢進 / 抗原誘発 / 気道過敏症 / サブスタンスP / 神経ペプチド / Endothelin / TNF-alpha / Cultured Epithelial Cells / Nasal Epithelial Cells / サイトカイン / アレルギー / - / 局所ステロイド / エンドセリン / TNF-α / 培養上皮細胞 / 鼻粘膜上皮細胞 / 鼻粘膜洗浄液 / 血管透過性亢進 / 鼻粘膜 / アンギオテンシン変換酵素(ACE) / ニュートラルエンドペプチデ-ス(NEP) … More Except Principal Investigator 好酸球性副鼻腔炎 / 好酸球性鼻副鼻腔炎 / 音響外傷 / ノックアウトマウス / 内耳障害 / 転写因子 / Erk-2 / 内耳性難聴 / 酸化ストレス / カンジダ / 真菌 / 難治性副鼻腔炎 / アレルギー性鼻炎 / type2炎症 / 腸内カンジダ / アンドロイド・ロボット / 医学教育 / 医療面接 / 患者ロボット / プロスタグランディン / マクロファージ遊走因子 / 病態研究 / 病態 / 遅延型過敏反応 / 皮内テスト / 腸内フローラ / type 2炎症 / 耳鳴 / 感音難聴 / 細胞死 / Erk / 蝸牛 / 急性感音難聴 / 鼻粘膜上皮 / 先制医療 / 疫学調査 / 鼻汁分泌 / 非侵襲的検査 / 分泌機能検査 / バリア機能 / 上皮間電位差 / 水分蒸散量 / 呼気凝集液 / 非侵襲検査 / 季節変動 / 抗原鼻誘発 / 高張食塩水 / 抗原特異的鼻粘膜誘発試験 / 鼻汁分泌能検査 / 鼻粘膜上皮バリア機能 / 糖鎖解析 / 鼻シルマーテスト / 音楽療法 / 鼻呼気凝集液 / 高調食塩水 / 鼻腔細菌叢 / 鼻粘膜バリア機能 / ドライノーズ / エンテロトキシン / 黄色ブドウ球菌 / 副鼻腔粘膜 / 鼻茸 / スギ / 総IｇE / 特異的IgE / 濾胞樹状細胞 / 菌体エンテロトキシン / 総IgE / 抗原特異的IgE / 篩骨洞粘膜 / 培養線維芽細胞 / エオタキシン / 増強効果 / プライミング効果 / ステロイド / マクロライド / 鼻アレルギー / 花粉症 / 舌下免疫療法 / スギ花粉症 / 免疫療法 Less

ヒト好酸球性鼻副鼻腔炎病態でのtype２炎症と腸内カンジダ増殖の関連についての研究
- Principal Investigator
  
  松根彰志
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Nippon Medical School
分子生体制御学的・行動解析学的アプローチによる内耳性難聴の発症メカニズムの解明
- Principal Investigator
  
  松延毅
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Nippon Medical School
Gut microbiome Candida as a new pathophysiological causative factor of intractable eosinophilic chronic rhinosinusitis
- Principal Investigator
  
  MATSUNE Shoji
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Nippon Medical School
Android-type Medial Interview Training System toward Advanced Education for Medical Communication
- Principal Investigator
  
  Hashimoto Takuya
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90140:Medical technology assessment-related
- Research Institution
  Tokyo University of Science
Biochemical and behavioral approach against inner ear disorder and development of new therapeutic modality
- Principal Investigator
  
  TAKESHI MATSUNOBU
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Nippon Medical School
Study of Adjuvant Immunotherapy for Allergic DiseasesPrincipal Investigator
- Principal Investigator
  
  OKUBO KIMIHIRO
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Nippon Medical School
Dry nose as a nasal epithelial barrier disorder and application to preemptive medicine
- Principal Investigator
  
  miwa masato
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Juntendo University
  Nippon Medical School
Study of topical antibody production in sinus mucosa of refractory rhinosinusitis cases
- Principal Investigator
  
  Matsune Shoji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Nippon Medical School
New therapy for refractory chronic sinusitis in application with priming effect of macrolide on steroid therapy
- Principal Investigator
  
  MATSUNE Shoji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Nippon Medical School
  Kagoshima University
The mechanism of sublingual immunotherapy, What is it?
- Principal Investigator
  
  GOTO Minoru
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Nippon Medical School
The development for control of hypersensitivity with nasal allergy for usinge explant culture techniquePrincipal Investigator
- Principal Investigator
  
  OKUBO Kimihiro
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Nippon Medical School
上気道過敏性におけるニュートラルエンドペプチデ-ス(NEP)Principal Investigator
- Principal Investigator
  
  大久保公裕
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Nippon Medical School
Cytokines produced from nasal epirhelial cellsPrincipal Investigator
- Principal Investigator
  
  OHKUBO Kimihiro
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Nippon Medical School

[Book] 耳鼻咽喉科と呼吸器疾患の関連性 [最新ガイドラインに基づく呼吸器疾患　診療指針]2022
- Author(s)
  松根彰志、大久保公裕
- Total Pages
  7
- Publisher
  総合医学社
- Data Source
  KAKENHI-PROJECT-19K09917
[Book] 耳鼻咽喉科と呼吸器疾患の関係（副鼻腔気管支症候群など）　呼吸器疾患診療ガイドライン　（弦間昭彦）2020
- Author(s)
  松根彰志、大久保公裕
- Publisher
  綜合医学社
- ISBN
  9784883787234
- Data Source
  KAKENHI-PROJECT-19K09917
[Book] アレルギー・リウマチ膠原病診療最新ガイドライン2012
- Author(s)
  松根彰志、大久保公裕
- Publisher
  総合医学社
- Data Source
  KAKENHI-PROJECT-22591901
[Journal Article] 当科におけるスギ花粉症に対するSLITの現状と評価　～JRQLQを用いて～2022
- Author(s)
  髙原恵理子、金井憲一, 松根彰志、大久保公裕
- Journal Title
  
  耳鼻咽喉科展望
  
  Volume: 65(5) Pages: 22-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09917
[Journal Article] Disease-modifying effect of Japanese cedar pollen sublingual immunotherapy tablets.2022
- Author(s)
  Yonekura S, Gotoh M, Kaneko S, Maekawa Y, Okubo K, Okamoto Y
- Journal Title
  
  J Allergy Clin Immunol in Pract.
  
  Volume: 9 Issue: 11 Pages: 4103-4116
- DOI
  10.1016/j.jaip.2021.06.060
- Data Source
  KAKENHI-PROJECT-18K09360
[Journal Article] Long-term sublingual immunotherapy provides better effects for patients with Japanese cedar pollinosis2021
- Author(s)
  Hamada Satoko、Kobayashi Yoshiki、Sakamoto Daiki、Shimamura Akihiro、Kuroda Kazumichi、Kawachi Risaki、Kanda Akira、Asako Mikiya、Gotoh Minoru、Okubo Kimihiro、Tomoda Koichi、Iwai Hiroshi
- Journal Title
  
  Auris Nasus Larynx
  
  Volume: － Issue: 4 Pages: 646-652
- DOI
  10.1016/j.anl.2021.01.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09901, KAKENHI-PROJECT-18K09360, KAKENHI-PROJECT-19K09920
[Journal Article] Long-term treatment of Japanese cedar pollinosis with Japanese cedar pollen SLIT drops and persistence of treatment effect: A post-marketing clinical trial2021
- Author(s)
  Nomura Y, Okubo K, Nakamura T, Sawaki S, Kitagou H, Idei N, Kaneko S, Kobayashi S, Tanaka Y, Okamoto Y
- Journal Title
  
  Allergol. Int.
  
  Volume: 70 Issue: 1 Pages: 96-104
- DOI
  10.1016/j.alit.2020.05.008
- NAID
  130007966818
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Data Source
  KAKENHI-PROJECT-18K09360
[Journal Article] Decreased numbers of metachromatic cells in nasal swabs in Japanese cedar pollinosis following sublingual immunotherapy.2020
- Author(s)
  Otsuka K, Otsuka H, Matsune S, Okubo K
- Journal Title
  
  Immun Inflamm Dis
  
  Volume: 8(3) Issue: 3 Pages: 333-341
- DOI
  10.1002/iid3.314
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09360, KAKENHI-PROJECT-19K09917
[Journal Article] Add on omalizumab for inadequently controlled severe pollinosis despite standard-of-care; a randomized study.2020
- Author(s)
  Okubo K, Okano M, Sato N, Tamaki Y, Suzuki H, Uddin A, Fogel R
- Journal Title
  
  J Allergy Clin Immunol Pract.
  
  Volume: 8(9) Issue: 9 Pages: 3130-3140.e2
- DOI
  10.1016/j.jaip.2020.04.068
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09360
[Journal Article] Preliminary Clinical Trial of Biomarkers to Predict Response to Sublingual Immunotherapy for Japanese Cedar Pollinosis2020
- Author(s)
  Takahara E, Matsune S, Ishida M, Wakayama N, Okubo K.
- Journal Title
  
  Journal of Nippon Medical School
  
  Volume: 87 Issue: 5 Pages: 277-284
- DOI
  10.1272/jnms.JNMS.2020_87-506
- NAID
  130007953908
- ISSN
  1345-4676, 1347-3409
- Year and Date
  2020-10-25
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09917
[Journal Article] Allergen-specific subcutaneous immunotherapy for Japanese cedar pollinosis decreases the number of metachromatic cells and eosinophils in nasal swabs during the preseason and in season.2020
- Author(s)
  Otsuka K, Otsuka H, Matsune S, Okubo K.
- Journal Title
  
  Immun Inflamm Dis.
  
  Volume: 8(3): Issue: 3 Pages: 258-266
- DOI
  10.1002/iid3.301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09917
[Journal Article] Causal Relationships Among Pollen Counts, Tweet Numbers, and Patient Numbers for Seasonal Allergic Rhinitis Surveillance: Retrospective Analysis2019
- Author(s)
  Shoko Wakamiya, Shoji Matsune, Kimihiro Okubo, Eiji Aramaki
- Journal Title
  
  Journal of Medical Internet Research
  
  Volume: 21 Issue: 2 Pages: e10450-e10450
- DOI
  10.2196/10450
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K16057, KAKENHI-PROJECT-19K09917
[Journal Article] Possibility of Local Allergic Rhinitis in Japan2019
- Author(s)
  Ishida M, Matsune S, Wakayama N, Ohashi R, Okubo K.
- Journal Title
  
  Am J Rhinol Allergy
  
  Volume: 34 Issue: 1 Pages: 26-34
- DOI
  10.1177/1945892419868441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09917, KAKENHI-PROJECT-16K20283
[Journal Article] 鼻呼気凝集液の臨床的意義2019
- Author(s)
  三輪正人村上亮介佐藤一樹大久保由布酒主敦子大久保公裕飯島史朗池田勝久奥村　康
- Journal Title
  
  耳鼻咽喉科ニューロサイエンス
  
  Volume: 36
- Data Source
  KAKENHI-PROJECT-17K11368
[Journal Article] Long-term efficacy and dose-finding trial of Japanese cedar pollen SLIT tablet.2019
- Author(s)
  Gotoh M, Yonekura S, Imai T, Kaneko S, Horikawa E, Konno A, Okamoto Y, Okubo K
- Journal Title
  
  J Allergy Clin Immunol Pract
  
  Volume: 7 Issue: 4 Pages: 1287-1297
- DOI
  10.1016/j.jaip.2018.11.044
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09360
[Journal Article] 鼻呼気凝集液の臨床的意義2019
- Author(s)
  三輪正人, 村上亮介, 佐藤一樹, 大久保由布, 酒主敦子, 大久保公裕, 飯島史朗, 池田勝久, 奥村康
- Journal Title
  
  耳鼻咽喉科ニューロサイエンス
  
  Volume: 33 Pages: 46-50
- Data Source
  KAKENHI-PROJECT-17K11368
[Journal Article] Nasal Symptoms Reduction and Decreased Neutrophilia in Japanese Cedar Pollinosis With Prophylactic Treatment With a Combination of Montelukast, Fexofenadine, and Fluticasone Nasal Spray.2019
- Author(s)
  Otsuka H, Otsuka K, Matsune S, Okubo K.
- Journal Title
  
  Am J Rhinol Allergy
  
  Volume: 33 Issue: 4 Pages: 369-77
- DOI
  10.1177/1945892419831924
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09917
[Journal Article] Serum Cytokine Interactions Are Implicated in the Mechanism of Action of Sublingual Immunotherapy for Japanese Cedar Pollinosis2018
- Author(s)
  Shimada K, Gotoh M, Okubo K, Hiroi T, Kaminuma O, Nakaya A
- Journal Title
  
  Journal of Nippon Medical School
  
  Volume: 85 Issue: 5 Pages: 250-258
- DOI
  10.1272/jnms.JNMS.2018_85-40
- NAID
  130007520427
- ISSN
  1345-4676, 1347-3409
- Year and Date
  2018-10-15
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09360
[Journal Article] Anti-Inflammatory Effects of EM900 on Cultured Human Nasal Epithelial Cells2018
- Author(s)
  Wakayama N, Matsune S, Takahara E, Sekine K, Yoshioka Y, Ishida M, Yamaguchi S, Okubo K, Sunazuka T, Omura S
- Journal Title
  
  Journal of Nippon Medical School
  
  Volume: 85 Issue: 5 Pages: 265-270
- DOI
  10.1272/jnms.JNMS.2018_85-42
- NAID
  130007520433
- ISSN
  1345-4676, 1347-3409
- Year and Date
  2018-10-15
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09360
[Journal Article] Treatment of nostril and nasal stenosis due to Facial burn using a self-expandable metallic esophageal stet2015
- Author(s)
  Kuwon Sekine, Shoji Matsune, Kyoko Shiiba, Maki Kimura, Kimihiro Okubo, Tadashi Kaneshiro, Hiroyuki Tajima, Masahiro Murakami, Akira Kurokawa
- Journal Title
  
  Auris Nasus Larynx
  
  Volume: 42 Pages: 348-352
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462589
[Journal Article] 鼻副鼻腔炎：総論ー副鼻腔炎から鼻副鼻腔炎へー2015
- Author(s)
  松根彰志、大久保公裕
- Journal Title
  
  神経内科
  
  Volume: 83 Pages: 485-490
- Open Access
- Data Source
  KAKENHI-PROJECT-26462589
[Journal Article] 耳鼻咽喉科領域疾患ーアレルギー性鼻炎、好酸球性副鼻腔炎、中耳などー2014
- Author(s)
  松根彰志、大久保公裕
- Journal Title
  
  PROGRESS IN MEDICINE
  
  Volume: 34 Pages: 1023-1025
- Data Source
  KAKENHI-PROJECT-26462589
[Journal Article] A randomized,double-blind,placebo-controlled study of Ten-Cha(Rubus suavissimus) on house dust mite allergic rhinitis2011
- Author(s)
  Yonekura S, Okamoto Y, Yamasaki K,Horiguchi S, Hanazawa T, Matsune S,Kurono Y, Yamada T, Fujieda S, Okano M,Okubo K
- Journal Title
  
  Auris Nasus Larynx
  
  Volume: 38(5) Pages: 600-7
- Data Source
  KAKENHI-PROJECT-22591901
[Journal Article] スギ花粉症に対する舌下免疫療法2009
- Author(s)
  後藤穣, 大久保公裕
- Journal Title
  
  臨床免疫・アレルギー 51
  
  Pages: 37-43
- NAID
  130004471408
- Data Source
  KAKENHI-PROJECT-18591891
[Journal Article] スギ花粉症に対する舌下免疫療法2009
- Author(s)
  後藤穣, 大久保公裕
- Journal Title
  
  臨床免疫・アレルギー科 51巻1号
  
  Pages: 37-43
- NAID
  130004471408
- Data Source
  KAKENHI-PROJECT-18591891
[Journal Article] Bepotastine besilate OD tablets suppress nasal symptoms caused by Japanese cedar pollen exposure in an artificial exposure chamber (OHIO Chamber)2009
- Author(s)
  Hashiguchi K, Tang H, Fujita T, Suematsu K, Gotoh M, Okubo K.
- Journal Title
  
  Expert Opin Pharmacother 10(4)
  
  Pages: 523-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591891
[Journal Article] Validation Study of the OHIO Chamber in Patients with Japanese Cedar Pollinosis2009
- Author(s)
  Hashiguchi K, Tang H, Fujita T, Suematsu K, Tsubaki S, Nagakura H, Kitajima S, Gotoh M, Okubo K.
- Journal Title
  
  Int Arch Allergy Immunol 149(2)
  
  Pages: 141-149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591891
[Journal Article] 乳酸菌Lactobacillus gasseri OLL2809のスギ花粉症改善効果2009
- Author(s)
  指原紀宏, 後藤穣, 大久保公裕, 他
- Journal Title
  
  アレルギーの臨床29巻 2号
  
  Pages: 155-159
- Data Source
  KAKENHI-PROJECT-18591891
[Journal Article] 乳酸菌Lactobacillus gasseri 0LL2809のスギ花粉症改善効果2009
- Author(s)
  指原紀宏, 後藤穣, 大久保公裕, 他.
- Journal Title
  
  アレルギーの臨床 29
  
  Pages: 109-112
- Data Source
  KAKENHI-PROJECT-18591891
[Journal Article] A randomized double-blind comparative study of sublingual. immunotherapy for cedar pollinosis2008
- Author(s)
  Okubo K, Gotoh M, et al.
- Journal Title
  
  Allergology international 57
  
  Pages: 265-275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591891
[Journal Article] Oral Administration of Heat-KilledLactobacillus gasseri OLL2809 Reduces Cedar Pollen Antigen-Induced Peritoneal Eosinophilia in Mice2008
- Author(s)
  Sashihara T, Ikegami S, Sueki N, Yamaji T, Kino K, Taketomo N, Gotoh M, Okubo K.
- Journal Title
  
  Allergol Int. 57(4)
  
  Pages: 397-403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591891
[Journal Article] A randomized double-blind comparative study of sublingual immunotherapy for cedar pollinosis2008
- Author(s)
  Okubo K, Gotoh M, Fujieda S, Okano M, Yoshida H, Morikawa H, Masuyama K, Okamoto Y, Kobayashi M.
- Journal Title
  
  Allergol Int. 57(3)
  
  Pages: 265-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591891
[Journal Article] スギ花粉症の舌下免疫療法2007
- Author(s)
  大久保公裕
- Journal Title
  
  Medico Page Vol.38 No.2
  
  Pages: 37-39
- Data Source
  KAKENHI-PROJECT-18591891
[Journal Article] アレルギー性鼻炎と自律神経2007
- Author(s)
  後藤穣、大久保公裕
- Journal Title
  
  アレルギー・免疫 14
  
  Pages: 56-61
- Data Source
  KAKENHI-PROJECT-18591891
[Journal Article] 花粉症治療における労働生産性の意義2007
- Author(s)
  大久保公裕, 小林慎
- Journal Title
  
  アレルギー・免疫 Vol.14 No.2
  
  Pages: 218-226
- NAID
  40015273119
- Data Source
  KAKENHI-PROJECT-18591891
[Journal Article] アレルギー免疫療法の普及をめざして-現状と将来-スギ花粉症に対する舌下免疫療法2007
- Author(s)
  後藤穣、大久保公裕、奥田稔
- Journal Title
  
  耳鼻免疫アレルギー 25
  
  Pages: 257-261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591891
[Journal Article] ベシル酸ベポタスチンOD錠によるスギ花粉症の症状抑制効果2007
- Author(s)
  橋口一弘、大久保公裕、後藤穣
- Journal Title
  
  新薬と臨床 56
  
  Pages: 81-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591891
[Journal Article] スギ花粉症における初期療法開始時期の検討(2006年シーズン)2007
- Author(s)
  後藤穣、大久保公裕, 他
- Journal Title
  
  アレルギー・免疫 14
  
  Pages: 96-101
- NAID
  40015537541
- Data Source
  KAKENHI-PROJECT-18591891
[Journal Article] Preliminary study on Japanese cedar pollinosis in an artificial exposure chamber (OHIO Chamber)2007
- Author(s)
  Hashiguchi K, Tang H, Fujita T, Tsubaki S, Fujita M, Suematsu K, Gotoh M, Okubo K.
- Journal Title
  
  Allergol Int. 56(2)
  
  Pages: 125-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591891
[Journal Article] スギ花粉症に対する舌下免疫療法2006
- Author(s)
  後藤穣, 島田健一, 大久保公裕, 奥田稔
- Journal Title
  
  免疫アレルギー Vol.24 No.2(CD-ROM)
- NAID
  10019945757
- Data Source
  KAKENHI-PROJECT-18591891
[Journal Article] 花粉症の病態と治療スギ花粉症に対するアレルゲン特異的免疫療法の現状と問題点2006
- Author(s)
  後藤穣, 大久保公裕
- Journal Title
  
  アレルギー科 Vol.21 No.1
  
  Pages: 13-21
- Data Source
  KAKENHI-PROJECT-18591891
[Journal Article] 免疫療法の展望2006
- Author(s)
  大久保公裕
- Journal Title
  
  日本耳鼻科学会会誌 Vol.45 No.1
  
  Pages: 84-86
- NAID
  10018115245
- Data Source
  KAKENHI-PROJECT-18591891
[Journal Article] Repeated antigen challenge in patients with perennial allergic rhinitis to house dust mite.2003
- Author(s)
  Gotoh M, Okubo K
- Journal Title
  
  Allergology International 52
  
  Pages: 207-212
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571642
[Journal Article] Repeated antigen challenge in patients with perennial allergic rhinitis to house dust mite.2003
- Author(s)
  Gotoh M, Okubo K, Okuda M
- Journal Title
  
  Allergology International 52
  
  Pages: 207-212
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571642
[Journal Article] The effect of substance P on the eosinophil migration of allergic nasal mucosa.
- Author(s)
  Okubo K, Gotoh M, Yagi T
- Journal Title
  
  Allergology International (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571642
[Journal Article] The effect of substance P on the eosinophil migration of allergic nasal mucosa.
- Author(s)
  Okubo K, Gotoh M, Yagi T
- Journal Title
  
  Allergology International (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571642
[Presentation] Dupilumabを投与した下気道疾患合併好酸球性副鼻腔炎の検討2023
- Author(s)
  細矢　慶、小町太郎、香中優美、春名良洋，後藤　穣、松根彰志、大久保公裕
- Organizer
  第3回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-19K09917
[Presentation] 川本法を用いた蝸牛の凍結切片作成の試み2023
- Author(s)
  臼倉典宏, 松延　毅, 大久保公裕
- Organizer
  第32回日本耳科学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K09569
[Presentation] 川本法を応用した蝸牛の凍結切片2023
- Author(s)
  臼倉典宏, 松延　毅, 大久保公裕
- Organizer
  第124回日本耳鼻咽喉科頭頸部外科学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K09569
[Presentation] スギ花粉症・ダニアレルギーにおける局所アレルギー反応性鼻炎（LAR)の可能性2022
- Author(s)
  春名良洋、松根彰志、石田麻里子、大久保公裕
- Organizer
  第123回日本耳鼻咽喉科頭頸部外科学会
- Data Source
  KAKENHI-PROJECT-19K09917
[Presentation] 好酸球性副鼻腔炎による嗅覚障害に対するデュピルマブの有効性2022
- Author(s)
  小町太郎、細矢　慶、吉野綾穂、久屋純子、梅景琴子、松根彰志、大久保公裕
- Organizer
  第123回日本耳鼻咽喉科頭頸部外科学会
- Data Source
  KAKENHI-PROJECT-19K09917
[Presentation] 川本法を用いた蝸牛の凍結切片作成の試み2022
- Author(s)
  臼倉典宏, 松延毅, 大久保公裕
- Organizer
  第32回日本耳科学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K09569
[Presentation] 模擬患者ロボットの音声対話システムの構築と面接者の頷きの抽出2021
- Author(s)
  本間悟史，橋本卓弥，藤倉輝道，早坂明哲，竹下俊行，伊藤保彦，大久保公裕，竹村裕
- Organizer
  日本機械学会ロボティクスメカトロニクス講演会2021(ROBOMECH2021)
- Data Source
  KAKENHI-PROJECT-19H04497
[Presentation] Voice Dialog System for Simulated Patient Robot and Detection of Interviewer Nodding2021
- Author(s)
  Takuya Hashimoto, Satoshi Honma, Terumichi Fujikura, Yoshiaki Hayasaka, Toshiyuki, Takeshita, Yasuhiko Ito, Kimihiro Okubo, Hiroshi Takemura
- Organizer
  IEEE Symposium Series on Computational Intelligence (IEEE SSCI 2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04497
[Presentation] 内耳性耳鳴におけるErkシグナルの機能的役割.2020
- Author(s)
  3.鈴木宏隆, 松延毅, 佐藤泰司,細谷誠, 藤岡正人, 渡部高久, 大久保公裕
- Organizer
  第29回日本耳科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-18K09359
[Presentation] 客観的臨床能力評価に向けたアンドロイド型模擬患者2020
- Author(s)
  藤倉輝道，早坂明哲，竹下俊行，伊藤保彦，大久保公裕，橋本卓弥，竹村裕
- Organizer
  第121回日本耳鼻咽喉科学会学術大会
- Data Source
  KAKENHI-PROJECT-19H04497
[Presentation] アンドロイド型模擬患者ロボットの開発2020
- Author(s)
  藤倉輝道，早坂明哲，竹下俊行，伊藤保彦，大久保公裕，橋本卓弥，竹村裕
- Organizer
  第52回日本医学教育学会大会
- Data Source
  KAKENHI-PROJECT-19H04497
[Presentation] Examination of local IgE and follicular dendritic cells in the endtype of eosinophilic chronic rhinosinusitis2019
- Author(s)
  Wakayama N,　Matsune S,　Okubo K
- Organizer
  WAC2019（World Allergy Congress)
- Data Source
  KAKENHI-PROJECT-19K09917
[Presentation] 好酸球性副鼻腔炎症例におけるリンパ濾胞形成及び濾胞性ヘルパーT細胞（TFH)の病理的検討2019
- Author(s)
  若山　望、松根彰志、大久保公裕
- Organizer
  第58回日本鼻科学会
- Data Source
  KAKENHI-PROJECT-19K09917
[Presentation] 圧刺激に対する粘膜上皮のCa2+オシレーション2019
- Author(s)
  三輪正人、高田弘弥、村上亮介、大久保公裕、小川令
- Organizer
  第37回耳鼻咽喉科ニューロサイエンス研究会
- Data Source
  KAKENHI-PROJECT-17K11368
[Presentation] 高張食塩水点鼻による鼻および口呼気凝集液中過酸化水素量の変動2018
- Author(s)
  酒主敦子　三輪正人　大久保由布　佐藤一樹　村上亮介　大久保公裕　飯島史郎
- Organizer
  第６回日本耳鼻咽喉科感染症・エアロゾル学会
- Data Source
  KAKENHI-PROJECT-17K11368
[Presentation] Peroxide tone in nasal exhaled breath condensate after nasal provocation2018
- Author(s)
  Masato Miwa, Atsuko Sakanushi, Yufu Ohkubo,Kazuki Sato, Ryosuke Murakami, Kimihiro Okubo, Shiro Iijima , Ko Okumura
- Organizer
  第２８回欧州呼吸器病学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11368
[Presentation] ドライノーズの病態評価の試み2017
- Author(s)
  三輪正人鈴木宏隆加藤大星村上亮介大久保公裕奥村康
- Organizer
  第118回日本耳鼻咽喉科学会
- Data Source
  KAKENHI-PROJECT-17K11368
[Presentation] 高張食塩水点鼻による鼻粘膜上皮機能の変化2017
- Author(s)
  大久保由布三輪正人佐藤一樹村上亮介酒主敦子大久保公裕ハウリー亜紀飯島史朗
- Organizer
  第5回日本耳鼻咽喉科感染症・エアロゾル学会
- Data Source
  KAKENHI-PROJECT-17K11368
[Presentation] 鼻シルマーテストの試み2017
- Author(s)
  佐藤一樹村上亮介酒主敦子三輪正人大久保公裕
- Organizer
  第56回日本鼻科学会
- Data Source
  KAKENHI-PROJECT-17K11368
[Presentation] ドライノーズの鼻腔細菌叢2017
- Author(s)
  佐藤一樹三輪正人大久保由布吉岡邦暁鈴木宏隆村上亮介酒主敦子大久保公裕
- Organizer
  第5回日本耳鼻咽喉科感染症・エアロゾル学会
- Data Source
  KAKENHI-PROJECT-17K11368
[Presentation] Dry nose disease の提言2017
- Author(s)
  三輪正人鈴木宏隆ハウリー亜紀飯島史朗大久保公裕池田勝久奥村　康
- Organizer
  第36回気道分泌研究会
- Data Source
  KAKENHI-PROJECT-17K11368
[Presentation] 鼻および口呼気凝集液の採取とその有用性の検討2017
- Author(s)
  鈴木宏隆三輪正人加藤大星佐藤一樹吉岡邦暁村上亮介酒主敦子大久保公裕池田勝久奥村　康
- Organizer
  第３５回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-17K11368
[Presentation] 新規マクロライド誘導体EM900のヒト鼻腔上皮細胞における抗炎症作用の検討2016
- Author(s)
  若山　望、高原恵理子、吉岡友真、佐藤一樹、松根彰j志、大久保公裕、砂塚敏明、大村　智
- Organizer
  日本鼻科学会
- Place of Presentation
  日本鼻科学会（第55回）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26462589
[Presentation] 黄色ブドウ球菌エンテロトキシン刺激による培養鼻粘膜上皮からのサイトカイン産生　～ダニ抗原刺激との比較～2016
- Author(s)
  高原恵理子、若山　望、松根彰志、大久保公裕
- Organizer
  日本耳鼻咽喉科感染症・エアロゾル学会
- Place of Presentation
  倉敷市
- Year and Date
  2016-09-02
- Data Source
  KAKENHI-PROJECT-26462589
[Presentation] 手術で得られた篩骨洞粘膜および下鼻甲介粘膜における抗原特異的抗体産生の比較検討2016
- Author(s)
  松根彰志、若山　望、吉岡友真、石田麻里子、関根久遠、山口　智、大久保公裕
- Organizer
  日本耳鼻咽喉科学会（第117回）
- Place of Presentation
  名古屋市
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26462589
[Presentation] One airway, One disease～耳鼻咽喉科医の立場から～2016
- Author(s)
  松根彰志、若山　望、吉岡友真、石田麻里子、関根久遠、山口　智、大久保公裕
- Organizer
  日本アレルギー学会大会
- Place of Presentation
  東京都
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-26462589
[Presentation] OSA－１８質問紙と簡易モニターを用いた小児の睡眠時無呼吸症候群の検討2015
- Author(s)
  吉岡友真、山口　智、石田麻里子、若山　望、関根久遠、松根彰志、大久保公裕
- Organizer
  第10回日本小児耳鼻咽喉科学会
- Place of Presentation
  軽井沢
- Year and Date
  2015-05-08
- Data Source
  KAKENHI-PROJECT-26462589
[Presentation] アレルギー性鼻炎の診断と下鼻甲介粘膜局所での抗原特異的IgE抗体産生2015
- Author(s)
  石田麻里子、若山　望、関根久遠、山口　智、松根彰志、大久保公裕
- Organizer
  第116回日本耳鼻咽喉科学会
- Place of Presentation
  東京都
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-26462589
[Presentation] 小児睡眠時無呼吸症候群と成長障害について～OSA-18質問紙と身長・体重の関連性～2015
- Author(s)
  吉岡友真、山口　智、若山　望、石田麻里子、関根久遠、勝部康弘、松根彰志、大久保公宏
- Organizer
  日本口腔・咽頭科学会
- Place of Presentation
  大阪市
- Year and Date
  2015-09-10
- Data Source
  KAKENHI-PROJECT-26462589
[Presentation] 突発性頭蓋内亢進症から髄液鼻漏を呈し当科受診した症例2015
- Author(s)
  若山　望、立山幸次郎、関根久遠、佐藤一樹,喜多村孝幸、松根彰志、大久保公裕
- Organizer
  第54回日本鼻科学会総会
- Place of Presentation
  広島市
- Year and Date
  2015-10-01
- Data Source
  KAKENHI-PROJECT-26462589
[Presentation] 下鼻甲介粘膜局所での抗原特異的IgE抗体産生とアレルギー性鼻炎の診断2015
- Author(s)
  石田麻里子、若山　望、関根久遠、山口　智、松根彰志、大久保公裕
- Organizer
  第64回日本アレルギー学会
- Place of Presentation
  東京都
- Year and Date
  2015-05-26
- Data Source
  KAKENHI-PROJECT-26462589
[Presentation] A double-blind cross-over controlled study of Pranlukast, a leukotriene receptor antagonist, against Japanese cedar pollinosis using the OHIO chamber2008
- Author(s)
  Okubo K, Hashiguchi K, Gotoh M et.al.
- Organizer
  7th symposium on experimental rhinology and immunology of the nose
- Place of Presentation
  Dubrovnik, Croatia
- Data Source
  KAKENHI-PROJECT-18591891
[Presentation] 一般演題「プランルカストのスギ花粉症に対する初期療法薬としての二重盲検比較試験-単独効果を中心に」2008
- Author(s)
  後藤穣、大久保公裕
- Organizer
  第47回日本鼻科学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-18591891
[Presentation] (シンポジウム)アレルギー性鼻炎の寛解と治癒2008
- Author(s)
  後藤穣, 大久保公裕, 奥田稔
- Organizer
  第20回日本アレルギー学会春期臨床大会
- Place of Presentation
  東京
- Year and Date
  2008-06-13
- Data Source
  KAKENHI-PROJECT-18591891
[Presentation] Japanese cedar pollinosis and circumstances. Harmony with climate and pollinosis2008
- Author(s)
  Okubo K, Gotoh M.
- Organizer
  8th International Society of Biometeorology
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-18591891
[Presentation] シンポジウム「アレルギー性鼻炎の寛解と治癒.」2008
- Author(s)
  後藤穣、大久保公裕、奥田稔
- Organizer
  第20回日本アレルギー学会春期臨床大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18591891
[Presentation] アレルギー性鼻炎・結膜炎診療の諸問題根治療法2007
- Author(s)
  後藤穣、大久保公裕、奥田稔
- Organizer
  第19回日本アレルギー学会春季臨床大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18591891
[Presentation] 花粉曝露室による第2世代抗ヒスタミン薬の薬効評価2007
- Author(s)
  後藤穣、大久保公裕
- Organizer
  第60回臨床アレルギー研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18591891
[Presentation] シンポジウム. アレルギー性鼻炎・結膜炎診療の諸問題根治療法2007
- Author(s)
  後藤穣、大久保公裕、奥田稔
- Organizer
  第19回日本アレルギー学会春季臨床大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18591891
[Presentation] シンポジウム. 花粉症の最新治療第2世代抗ヒスタミン薬2007
- Author(s)
  後藤穣、大久保公裕
- Organizer
  第57回日本アレルギー学会秋季学術大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18591891
[Presentation] The clinical role and efficacy of pranlukast on allergic rhinitis. Symposium ; The role of luekotorien receptor antagonist on bronchial asthma and allergic rhinitis2007
- Author(s)
  Okubo k, Gotoh M, Okamoto Y.
- Organizer
  World Allergy Congress
- Place of Presentation
  Bangkok, Thai
- Data Source
  KAKENHI-PROJECT-18591891
[Presentation] 一般演題「スギ花粉症に対する舌下免疫療法」2006
- Author(s)
  後藤穣、大久保公裕
- Organizer
  第107回日本耳鼻咽喉科学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18591891
[Presentation] シンポジウム「スギ花粉症に対する舌下免疫療法の二重盲検比較試験」2006
- Author(s)
  後藤穣、大久保公裕
- Organizer
  第56回日本アレルギー学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18591891

1. MATSUNE Shoji (00253899)

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Ohkubo Kimihiro 大久保 公裕

OKUBO KIMIHIRO 大久保 公裕

OHKUBO Kimihiro 大久保 公裕

大久保 公裕 オオクボ キミヒロ

OKUBO Kimihiro 大久保 公裕

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Study of Adjuvant Immunotherapy for Allergic DiseasesPrincipal Investigator

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The development for control of hypersensitivity with nasal allergy for usinge explant culture techniquePrincipal Investigator

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上気道過敏性におけるニュートラルエンドペプチデ-ス(NEP)Principal Investigator

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Cytokines produced from nasal epirhelial cellsPrincipal Investigator

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[Book] 耳鼻咽喉科と呼吸器疾患の関連性 [最新ガイドラインに基づく呼吸器疾患 診療指針]2022

Author(s)

Total Pages

Ohkubo Kimihiro 大久保公裕

OKUBO KIMIHIRO 大久保公裕

OHKUBO Kimihiro 大久保公裕

大久保公裕オオクボキミヒロ

OKUBO Kimihiro 大久保公裕

[Book] 耳鼻咽喉科と呼吸器疾患の関連性 [最新ガイドラインに基づく呼吸器疾患　診療指針]2022

[Book] 耳鼻咽喉科と呼吸器疾患の関係（副鼻腔気管支症候群など）　呼吸器疾患診療ガイドライン　（弦間昭彦）2020

[Journal Article] 当科におけるスギ花粉症に対するSLITの現状と評価　～JRQLQを用いて～2022