Mizogami Maki 溝上真樹

… Alternative Names

MIZOGAMI Maki 溝上真樹

溝上真樹ミゾガミマキ

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Researcher Number	10231614
Other IDs
External Links
Affiliation (Current)	2025: 社会医療法人厚生会中部国際医療センター(研究支援センター), がん研究部, 研究員
Affiliation (based on the past Project Information) *help	2022 – 2024: 社会医療法人厚生会中部国際医療センター(研究支援センター), がん研究部, 研究員 2018 – 2019: 福井大学, 学術研究院医学系部門, 特別研究員 2017: 福井大学, 医学部器官制御医学講座麻酔・蘇生学領域, 特別研究員 2016 – 2017: 福井大学, 学術研究院医学系部門(附属病院部), 講師 2011 – 2015: 福井大学, 医学部附属病院, 講師 … More 2010: 朝日大学, 歯学部, 准教授 2008: 朝日大学, 歯学部, 准教授 2003 – 2005: 朝日大学, 歯学部, 助教授 1994: 福井医科大学, 医学部, 助手 1991 – 1992: 福井医科大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 55050:Anesthesiology-related / Anesthesiology / Anesthesiology/Resuscitation studies Except Principal Investigator Surgical dentistry / Basic Section 57060:Surgical dentistry-related / 麻酔学
Keywords	Principal Investigator 麻酔薬 / 抗腫瘍薬 / がん細胞 / マイクロドメイン / 細胞膜 / 麻酔学 / 個人差 / 生体膜相互作用 / サクシニルコリン / ラット … More / 31P-NMR / 骨格筋 / エネルギー代謝 / 除神経 … More Except Principal Investigator 麻酔薬 / 膜流動性 / 相互作用 / 生体膜 / 膜流動性変化 / 局所麻酔薬 / 機序的膜相互作用 / コレステロール / 植物成分 / 全身麻酔薬 / 薬力学的相互作用 / 薬理学的機序 / 膜脂質 / 特異的 / SARS-CoV-2感染 / COVID-19口腔症状 / COVID-19罹患後口腔症状 / カプサイシン / アセトアミノフェン / 機序的生体膜相互作用 / NSAIDs / 非ステロイド系抗炎症薬 / COVID-19 / 薬物選択基準 / 適用薬 / マルチモーダル鎮痛 / 異性体識別 / 薬物識別 / 立体特異性 / 膜脂質二重層 / キラル / 薬理学的多様性 / Pharmacological Mechanism / Hair Analysis / Membrane Fluidization / Beta-carbolines / Interaction / Decreased Effects / Drinking / Anesthetics / 哺乳類アルカロイド / 局所・全身麻酔薬 / 麻酔効果減弱 / リポソーム / 生体膜流動性 / 立体異性体 / 生体膜マイクロドメイン / β-カルボリンアルカロイド / 毛髪分析 / 膜流動化 / β-カルボリン / 効果減弱 / 飲酒 / Sympathetic Irritability / Sympathetic Excitability / Vagal Activity / Trendograph of R-R interval Variations / Fast Fourier Transform(FFT) / Neurovegetative Dominancy / Neurovegetative Balance Control Ability / 自律神経機能総合検査解析システム / 心電図RーR間隔 / 自律神経機能総合的検査解析システム / 高速フ-リエ解析 / 星状神経節ブロック / 交感神経被刺激性 / 高速フーリ解析 / 迷走神経活動度 / 交感神経興奮度 / 交感神経被剌激性 / 交感神経優位度 / 自律神経系バランス調節能 / 心電図R-R間隔変動値 / 自律神経機能 / アルカロイド / フラボノイド / 植物性サプリメント / 機序的膜作用 / 麻酔補助薬 / 生体膜脂質 / 膜作用機序 / サプリメント / ハーブ / 機序 / 食物成分 / 薬力学的 / 脂質 / 麻酔関連薬 / 飲食物成分 / 麻酔機序 / 脂質過酸化 / 効果減弱と炎症 / 麻酔作用と心毒性 / 脂質組成 / 生体膜相互作用 / 構造-膜活性相関 / 構造特異性 / 薬物立体構造 / 心毒性 / ラフト / 作用機序 Less

生体膜の機序的流動化を基軸とした麻酔薬による抗腫瘍戦略Principal Investigator
- Principal Investigator
  
  溝上真樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Social Medical Corporation Central Japan International Medical Center Research Support Center
Drug-Selection Standard for Multimodal Analgesia Using Mechanistic Membrane Interactivity Specific to Each Applicable Drug
- Principal Investigator
  
  Tsuchiya Hironori
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Asahi University
Pharmacological diversity of anesthetics is produced by their interactions with chiral biomembranes: mechanistic backgrounds and clinical implications
- Principal Investigator
  
  Tsuchiya Hironori
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Asahi University
A novel pharmacodynamic approach to assess individual differences in anesthetic response: The function of lipids in biological membranePrincipal Investigator
- Principal Investigator
  
  Mizogami Maki
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  University of Fukui
Novel pharmacodynamic interactions of anesthetics: Anesthetic effects decreased or increased by herbs and supplements in the perioperative period
- Principal Investigator
  
  TSUCHIYA Hironori
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Asahi University
Anesthetic effects decreased or increased by the novel pharmacodynamic interactions on biomembrane lipids
- Principal Investigator
  
  TSUCHIYA Hironori
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Asahi University
Reverification of the mechanistic membrane effects of anesthetics : Interactions with biomembrane rafts and specific membrane lipids
- Principal Investigator
  
  TSUCHIYA Hironori
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Asahi University
The interaction between Mammalian Alkaloids and Anesthetics : Anesthetic Tolerance Associated with Alcohol Drinking and Prediction by Hair Analysis
- Principal Investigator
  
  TSUCHIYA Hironori
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Asahi University
除神経骨格筋に対するサクシニルコリン異常反応の研究-31-NMR法を用いて-Principal Investigator
- Principal Investigator
  
  溝上真樹
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  福井医科大学
Trial Product of the Autonomic Nerve Function Analyzable System availed the Fluctuation of the R-R interval variations of ECG
- Principal Investigator
  
  GOTO Yukio
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  麻酔学
- Research Institution
  Fukui Medical School

[Journal Article] Acetaminophen Has Lipid Composition-Dependent Membrane Interactivity That Could be Related to Nephrotoxicity but Not to Analgesic Activity and Hepatotoxicity2022
- Author(s)
  Maki Mizogami and Hironori Tsuchiya
- Journal Title
  
  Medical Principles and Practice
  
  Volume: 31 Issue: 2 Pages: 111-117
- DOI
  10.1159/000524210
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K10152
[Journal Article] Membrane Interactivity of Capsaicin Antagonized by Capsazepine2022
- Author(s)
  Maki Mizogami and Hironori Tsuchiya
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 7 Pages: 3971-3971
- DOI
  10.3390/ijms23073971
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K10152
[Journal Article] Interaction of drugs with lipid raft membrane domains as a possible target2020
- Author(s)
  Hironori Tsuchiya, Maki Mizogami
- Journal Title
  
  Drug Target Insights
  
  Volume: 14 Issue: 1 Pages: 34-47
- DOI
  10.33393/dti.2020.2185
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K10152
[Journal Article] Sudden cardiac arrest due to coronary vasospasm in a patient with Wolff-Parkinson-White syndrome during brain surgery: a case report.2019
- Author(s)
  Matsuki Y, Mizogami M and Shigemi K
- Journal Title
  
  JA Clinical Reports
  
  Volume: 5 Issue: 1 Pages: 13-13
- DOI
  10.1186/s40981-019-0233-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10931
[Journal Article] Membrane interactivity of anesthetic adjuvant dexmedetomidine discriminable from clonidine and enantiomeric levomedetomidine.2019
- Author(s)
  Mizogami M, Tsuchiya H
- Journal Title
  
  Journal of Advances in Medicine and Medical Research
  
  Volume: 29(11) Pages: 1-15
- DOI
  10.9734/jammr/2019/v29i1130142
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10931, KAKENHI-PROJECT-17K11924
[Journal Article] Membrane Interactivity of Non-steroidal Anti-inflammatory Drugs: A Literature Review2019
- Author(s)
  Tsuchiya H, Mizogami M
- Journal Title
  
  Journal of Advances in Medicine and Medical Research
  
  Volume: 31(9) Pages: 1-30
- DOI
  10.9734/jammr/2019/v31i930320
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10931, KAKENHI-PROJECT-17K11924
[Journal Article] Hypothetical Review: Herbs affect anesthesia by the pharmacokinetic and pharmacodynamic interactions of herbal phytochemical components with anesthetic agents2018
- Author(s)
  Hironori Tsuchiya and Maki Mizogami
- Journal Title
  
  Reviews and Reports Press
  
  Volume: 2 Pages: 44-54
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11924
[Journal Article] Reliability and validity of the Japanese translation of the DN4 Diagnostic Questionnaire in patients with neuropathic pain.2018
- Author(s)
  Matsuki Y, Sukenaga N, Miyagi K, Tsunetoh T, Mizogami M, Shigem K, Maeda L, Hirose M
- Journal Title
  
  Journal of Anesthesia
  
  Volume: 32(3) Issue: 3 Pages: 403-408
- DOI
  10.1007/s00540-018-2495-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10931
[Journal Article] Herbs affect anesthesia by the pharmacokinetic and pharmacodynamic interactions of herbal phytochemical components with anesthetic agents.2018
- Author(s)
  Tsuchiya H, Mizogami M
- Journal Title
  
  Reviews and Reports Press
  
  Volume: 2(1) Pages: 44-54
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10931
[Journal Article] A randomized controlled trial to verify the efficacy of alkalinized local anesthetics in ultrasound-guided supraclavicular brachial plexus block.2017
- Author(s)
  Tsugita　Ｋ, Matsuki　Ｙ, Murakami　Ｔ, Mizogami　Ｍ, Shigemi　Ｋ．
- Journal Title
  
  Anaesthesia, Pain & Intensive Care
  
  Volume: 21（3） Pages: 301-305
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10931
[Journal Article] Discrimination of Stereoisomers by Their Enantioselective Interactions with Chiral Cholesterol-Containing Membranes.2017
- Author(s)
  Tsuchiya H, Mizogami M
- Journal Title
  
  Molecules
  
  Volume: 23（１） Issue: 1 Pages: 49-49
- DOI
  10.3390/molecules23010049
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10931, KAKENHI-PROJECT-17K11924
[Journal Article] Analgesic Agents Share the Membrane Interactivity Possibly Associated with the Diversity of Their Pharmacological Properties2015
- Author(s)
  Hironori Tsuchiya and Maki Mizogami
- Journal Title
  
  British Journal of Pharmaceutical Research
  
  Volume: 7 Issue: 2 Pages: 110-121
- DOI
  10.9734/bjpr/2015/18269
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26463078
[Journal Article] Drinking-Related Tetrahydroharmans Counteract the Membrane Effects of Local Anesthetic Lidocaine2014
- Author(s)
  Hironori Tsuchiya and Maki Mizogami
- Journal Title
  
  Journal of Drug and Alcohol Research
  
  Volume: 3 Pages: 1-6
- DOI
  10.4303/jdar/235887
- NAID
  120005591305
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26463078
[Journal Article] Comparative Interactions of Anesthetic Alkylphenols with Lipid Membranes2014
- Author(s)
  Hironori Tsuchiya, Maki Mizogami
- Journal Title
  
  Open Journal of Anesthesiology
  
  Volume: 4 Issue: 12 Pages: 308-317
- DOI
  10.4236/ojanes.2014.412044
- NAID
  120005591306
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26463078
[Journal Article] Interactions of Local Anesthetics with Biomembranes Consisting of Phospholipids and Cholesterol: Mechanistic and Clinical Implications for Anesthetic and Cardiotoxic Effects2013
- Author(s)
  Hironori Tsuchiya and Maki Mizogami
- Journal Title
  
  Anesthesiology Research and Practice
  
  Volume: 2013 Pages: 1-18
- DOI
  10.1155/2013/297141
- NAID
  120006681404
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23593005
[Journal Article] Characteristic interactivity of landiolol, an ultra-short-acting highly selective beta1-blocker, with biomimetic membranes: comparisons with beta1-selective esmolol and non-selective propranolol and alprenolol2013
- Author(s)
  Hironori Tsuchiya and Maki Mizogami
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 4 Pages: 1-8
- DOI
  10.3389/fphar.2013.00150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23593005
[Journal Article] R(+)-, Rac-, and S(-)-Bupivacaine Stereostructure-Specifically Interact with Membrane Lipids at Cardiotoxically Relevant Concentrations2012
- Author(s)
  Hironori Tsuchiya and Maki Mizogami
- Journal Title
  
  Anesthesia and Analgesia
  
  Volume: 114 Issue: 2 Pages: 310-312
- DOI
  10.1213/ane.0b013e31823ed410
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23593005
[Journal Article] Increasing Membrane Interactions of Local Anaesthetics as Hypothetic Mechanism for Their Cardiotoxicity Enhanced by Myocardial Ischaemia2012
- Author(s)
  Hironori Tsuchiya, Maki Mizogami and Kenji Shigemi
- Journal Title
  
  Basic and Clinical Pharmacology and Toxicology
  
  Volume: 111 Issue: 5 Pages: 303-308
- DOI
  10.1111/j.1742-7843.2012.00909.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23593005
[Journal Article] Cardiotoxic Local Anesthetics Increasingly Interact with Biomimetic Membranes under Ischemia-Like Acidic Conditions2012
- Author(s)
  Hironori Tsuchiya, Maki Mizogami, Takahiro Ueno, and Kenji Shigemi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 35 Pages: 988-992
- NAID
  130001872187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23593005
[Journal Article] Plant Components Exhibit Pharmacological Activities and Drug Interactions by Acting on Lipid Membranes2012
- Author(s)
  Hironori Tsuchiya, Maki Mizogami
- Journal Title
  
  Pharmacognosy Communications
  
  Volume: 2 Pages: 58-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23593005
[Journal Article] The membrane interaction of drugs as one of mechanisms for their enantioselective effects2012
- Author(s)
  Hironori Tsuchiya, Maki Mizogami
- Journal Title
  
  Medical Hypotheses
  
  Volume: 79 Issue: 1 Pages: 65-67
- DOI
  10.1016/j.mehy.2012.04.001
- NAID
  120005541897
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23593005
[Journal Article] Stereostructure-based differences in the interactions of cardiotoxic local anesthetics with cholesterol-containing biomimetic membranes2011
- Author(s)
  Hironori Tsuchiya, Takahiro Ueno, Maki Mizogami
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Stereostructure-based differences in the interactions of cardiotoxic local anesthetics with cholesterol-containing biomimetic membranes2011
- Author(s)
  Hironori Tsuchiya, Takahiro Ueno, Maki Mizogami
- Journal Title
  
  Bioorganic and Medicinal Chemistry
  
  Volume: 19 Issue: 11 Pages: 3410-3415
- DOI
  10.1016/j.bmc.2011.04.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23593005
[Journal Article] Stereostructure-based differences in the interactions of cardiotoxic local anesthetics with cholesterol-containing biomimetic membranes2011
- Author(s)
  Hironori Tsuchiya, Takahiro Ueno, Maki Mizogami
- Journal Title
  
  Bioorganic & Medicinal Chemistry (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Do local anesthetics interact preferentially with membrane lipid rafts? Comparative interactivities with raft-like membranes2010
- Author(s)
  Hironori Tsuchiya・Takahiro Ueno・Maki Mizogami・Ko Takakura
- Journal Title
  
  Journal of Anesthesia
  
  Volume: 24 Pages: 639-642
- NAID
  10026632900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Comparative study on determination of antioxidant and membrane activities of propofol and its related compounds2010
- Author(s)
  Hironori Tsuchiya, Takahiro Ueno, Toshiyuki Tanaka, Nobuyasu Matsuura, Maki Mizogami
- Journal Title
  
  European Journal of Pharmaceutical Sciences 39
  
  Pages: 97-102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Comparative study on determination of antioxidant and membrane activities of propofol and its related compounds2010
- Author(s)
  Hironori Tsuchiya, Takahiro Ueno, Toshiyuki Tanaka, Nobuyasu Matsuura, Maki Mizogami
- Journal Title
  
  European Journal of Pharmaceutical Sciences
  
  Volume: 39 Pages: 97-102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] The interactivities with lipid membranes differentially characterize selective and nonselective β_1-blockers2010
- Author(s)
  Maki Mizogami, Ko Takakura, Hironori Tsuchiya
- Journal Title
  
  European Journal of Anaesthesiology Vol.27
  
  Pages: 829-834
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Local anesthetics structure-dependently interact with anionic phospholipid membranes to modify the fluidity2010
- Author(s)
  Hironori Tsuchiya, Takahiro Ueno, Maki Mizogami, Ko Takakura
- Journal Title
  
  Chemico-Biological Interactions
  
  Volume: 183 Pages: 19-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Do local anesthetics interact preferentially with membrane lipid rafts? Comparative interactivities with raft-like membranes2010
- Author(s)
  Hironori Tsuchiya・Takahiro Ueno・Maki Mizogami・Ko Takakura
- Journal Title
  
  Journal of Anesthesia Vol. 4
  
  Pages: 639-642
- NAID
  10026632900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Local anesthetics structure-dependently interact with anionic phospholipid membranes to modify the fluidity2010
- Author(s)
  Hironori Tsuchiya, Takahiro Ueno, Maki Mizogami, Ko Takakura
- Journal Title
  
  Chemico-Biological Interactions Vol.183
  
  Pages: 19-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Local anesthetics structure-dependently interact with anionic phospholipid membranes to modify the fluidity2010
- Author(s)
  Hironori Tsuchiya, Takahiro Ueno, Maki Mizogami, Ko Takakura
- Journal Title
  
  Chemico-Biological Interactions 183
  
  Pages: 19-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Comparative study on determination of antioxidant and membrane activities of propofol and its related compounds2010
- Author(s)
  Hironori Tsuchiya, Takahiro Ueno, Toshiyuki Tanaka, Nobuyasu Matsuura, Maki Mizogami
- Journal Title
  
  European Journal of Pharmaceutical Sciences Vol.39
  
  Pages: 97-102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] The interactivities with lipid membranes differentially characterize selective and nonselective β_1-blockers2010
- Author(s)
  Maki Mizogami, Ko Takakura, Hironori Tsuchiva
- Journal Title
  
  European Journal of Anaesthesiology
  
  Volume: 27 Pages: 829-834
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Local anesthetic failure associated with inflammation : verification of the acidosis mechanism and the hypothetic participation of inflammatory peroxynitrite2008
- Author(s)
  Takahiro Ueno, Hironori Tsuchiya, Maki Mizogami, Ko Takakura
- Journal Title
  
  Journal of Inflammation Research Vol.1
  
  Pages: 41-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Peroxynitrite affects lidocaine by acting on membrane-constituting lipids2008
- Author(s)
  Takahiro Ueno, Maki Mizogami Ko Takakura, Hironori Tsuchiva
- Journal Title
  
  Journal of Anesthesia 22
  
  Pages: 475-478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Membrane effect of lidocaine is inhibited by interaction with peroxynitrite2008
- Author(s)
  Takahiro Ueno, Maki MizogamiKo Takakura, Hironori Tsuchiva
- Journal Title
  
  Journal of Anesthesia 22
  
  Pages: 96-99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Anesthetic and Cardiotoxic Effects in the Light of the Interactions of Local Anesthetics and Membrane Lipids2008
- Author(s)
  Takahiro Ueno, Maki Mizogami Ko Takakura, Hironori Tsuchiva
- Journal Title
  
  Journal of the Pharmaceutical Society of Japan 128(Suppl. 2)
  
  Pages: 33-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Local anesthetic failure associated with inflammation : verification of the acidosis mechanism and the hypothetic participation of inflammatory peroxynitrite2008
- Author(s)
  Takahiro Ueno, Hironori Tsuchiya, Maki Mizogami, Ko Takakura
- Journal Title
  
  Journal of Inflammation Research
  
  Volume: 1 Pages: 41-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Antioxidant Activity Analysis by Liposomal Membrane System and Application to Anesthetics2008
- Author(s)
  Hironori TSUCHIYA, Takahiro UENO, Maki MIZOGAMI, and Ko TAKAKURA
- Journal Title
  
  Analytical Sciences
  
  Volume: 24 Pages: 1557-1562
- NAID
  10025208626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Antioxidant Activity Analysis by Liposomal Membrane System and Application to Anesthetics2008
- Author(s)
  Hironori TSUCHIYA, Takahiro UENO, Maki MIZOGAMI, Ko TAKAKURA
- Journal Title
  
  Analytical Sciences Vol.24
  
  Pages: 1557-1562
- NAID
  10025208626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Membrane interactivity of charged local anesthetic derivative and stereoselectivity in membrane interaction of local anesthetic enantiomers2008
- Author(s)
  Hironori Tsuchiya, Maki Mizogami
- Journal Title
  
  Local and Regional Anesthesia 1
  
  Pages: 1-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Anesthetic and Cardiotoxic Effects in the Light of the Interactions of Local Anesthetics and Membrane Lipids2008
- Author(s)
  Takahiro Ueno, Maki Mizogami, Ko Takakura and Hironori Tsuchiya
- Journal Title
  
  Journal of the Pharmaceutical Society of Japan
  
  Volume: 128(Suppl.2) Pages: 33-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Local anesthetic failure associated with inflammation : verification of the acidosis mechanism and the hypothetic participation of inflammatory peroxynitrite2008
- Author(s)
  Takahiro Ueno, Hironori Tsuchiya, Maki Mizogami, et al.
- Journal Title
  
  Journal of Inflammation Research 1
  
  Pages: 41-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Peroxynitrite affects lidocaine by acting on membrane-constituting lipids2008
- Author(s)
  TAKAHIRO UENO, MAKI MIZOGAMI, KO TAKAKURA, HIRONORI TSUCHIYA
- Journal Title
  
  Journal of Anesthesia Vol.22
  
  Pages: 475-478
- NAID
  10024461090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Stereospecific Interaction of Bupivacaine Enantiomers with Lipid Membranes2008
- Author(s)
  Maki Mizogami, Hironori Tsuchiya, Takahiro Ueno, Masanori Kashimata, Ko Takakura
- Journal Title
  
  Regional Anesthesia and Pain Medicine Vol.33
  
  Pages: 304-311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Stereospecific Interaction of Bupivacaine Enantiomers with Lipid Membranes2008
- Author(s)
  Maki Mizogami, Hironori Tsuchiya, Takahiro Ueno, Masanori Kashimata, and Ko Takakura
- Journal Title
  
  Regional Anesthesia and Pain Medicine
  
  Volume: 33 Pages: 304-311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Membrane effect of lidocaine is inhibited by interaction with peroxynitrite2008
- Author(s)
  TAKAHIRO UENO, MAKI MIZOGAMI, KO TAKAKURA, HIRONORI TSUCHIYA
- Journal Title
  
  Journal of Anesthesia Vol.22
  
  Pages: 96-99
- NAID
  10024128841
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Membrane effect of lidocaine is inhibited by interaction with peroxynitrite2008
- Author(s)
  TAKAHIRO UENO, MAKI MIZOGAMI, KO TAKAKURA, and HIRONORI TSUCHIYA
- Journal Title
  
  Journal of Anesthesia
  
  Volume: 22 Pages: 96-99
- NAID
  10024128841
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Peroxynitrite affects lidocaine by acting on membrane-constituting lipids2008
- Author(s)
  TAKAHIRO UENO, MAKI MIZOGAMI, KO TAKAKURA, and HIRONORI TSUCHIYA
- Journal Title
  
  Journal of Anesthesia
  
  Volume: 22 Pages: 475-478
- NAID
  10024461090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Membrane interactivity of charged local anesthetic derivative and stereoselectivity in membrane interaction of local anesthetic enantiomers2008
- Author(s)
  Hironori Tsuchiya, Maki Mizogami
- Journal Title
  
  Local and Regional Anesthesia Vol.1
  
  Pages: 1-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Anesthetic and Cardiotoxic Effects in the Light of the Interactions of Local Anesthetics and Membrane Lipids2008
- Author(s)
  Takahiro Ueno, Maki Mizogami, Ko Takakura, Hironori Tsuchiya
- Journal Title
  
  Journal of the Pharmaceutical Society of Japan Vol.128 (Suppl.2)
  
  Pages: 33-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Antioxidant Activity Analysis by Liposomal Membrane System and Application to Anesthetics2008
- Author(s)
  Hironori TSUCHIYA, Takahiro UENO, Maki MIZOGAMI, Ko TAKAKURA
- Journal Title
  
  Analytical Sciences 24
  
  Pages: 1557-1562
- NAID
  10025208626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Membrane interactivity of charged local anesthetic derivative and stereoselectivity in membrane interaction of local anesthetic enantiomers2008
- Author(s)
  Hironori Tsuchiya, Maki Mizogami
- Journal Title
  
  Local and Regional Anesthesia
  
  Volume: 1 Pages: 1-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Stereospecific Interaction of Bupivacaine Enantiomers with Lipid Membranes2008
- Author(s)
  Maki Mizogami, Hironori Tsuchiya, Takahiro Ueno, et al.
- Journal Title
  
  Regional Anesthesia and Pain Medicine 33
  
  Pages: 304-311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592381
[Journal Article] Reversed-phase liquid chromatographic retention and membrane activity relationships of local anesthetics2005
- Author(s)
  Hironori Tsuchiya, Maki Mizogami, Ko Takakura
- Journal Title
  
  Journal of Chromatography A 1073
  
  Pages: 303-308
- Data Source
  KAKENHI-PROJECT-15592145
[Journal Article] The Interaction of Local Anesthetic Quaternary Ammonium Derivative and Stereoisomers with Membrane Lipids2005
- Author(s)
  Hironori Tsuchiya, Maki Mizogami, Masanori Kashimata, Ko Takakura
- Journal Title
  
  Journal of the Pharmaceutical Society of Japan 125・Suppl.4
  
  Pages: 148-149
- Data Source
  KAKENHI-PROJECT-15592145
[Journal Article] Reversed-phase liquid chromatographic retention and membrane activity relationships of local anesthetics2005
- Author(s)
  Hironori Tsuchiya, Maki Mizogami, Ko Takakura
- Journal Title
  
  Journal of Chromatography A (in press)
- Data Source
  KAKENHI-PROJECT-15592145
[Journal Article] 構造ならびに液性に依存した局所麻酔薬の膜流動化作用と逆相分配HPLC保持能2004
- Author(s)
  土屋博紀, 溝上真樹, 大嶋和之, 柏俣正典, 高倉康
- Journal Title
  
  薬学雑誌 124・Suppl.4
  
  Pages: 133-136
- Data Source
  KAKENHI-PROJECT-15592145
[Journal Article] Local Anesthetics Adsorbed onto Infusion Balloon2004
- Author(s)
  Maki Mizogami, Hironori Tsuchiya, Ko Takakura
- Journal Title
  
  Anesthesia and Analgesia 99
  
  Pages: 764-768
- Data Source
  KAKENHI-PROJECT-15592145
[Journal Article] Local Anesthetics Adsorbed onto Infusion Balloon2004
- Author(s)
  Maki Mizogami, et al.
- Journal Title
  
  Anesthesia and Analgesia 99
  
  Pages: 764-768
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15592145
[Journal Article] 新規β1選択的遮断薬の膜作用の可能性2004
- Author(s)
  大嶋和之, 溝上真樹, 土屋博紀, 永山元彦, 高倉康
- Journal Title
  
  薬学雑誌 124・Suppl.4
  
  Pages: 129-132
- Data Source
  KAKENHI-PROJECT-15592145
[Journal Article] Hypothetic Mechanism for Decreased Local Anesthetic Effects in Inflamed Tissues Influences of pH and Peroxynitrite on Membrane Fluidization by Local Anesthetics-2003
- Author(s)
  Maki MIZOGAMI, et al.
- Journal Title
  
  Journal of the Pharmaceutical Society of Japan 123(Suppl.4)
  
  Pages: 201-204
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15592145
[Journal Article] 炎症組織における局所麻酔効果減弱の仮説的機序-局所麻酔薬の膜流動化作用に及ぼすpHとPeroxynitriteの影響-2003
- Author(s)
  溝上真樹, 他
- Journal Title
  
  薬学雑誌 123(Suppl.4)
  
  Pages: 201-204
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15592145
[Presentation] マルチモーダル鎮痛に用いられる薬物の膜相互作用（Ⅵ）：COX-2選択性が異なるNSAIDsの機序的な生体膜相互作用の比較2023
- Author(s)
  溝上真樹、土屋博紀
- Organizer
  日本麻酔科学会第70回学術集会
- Data Source
  KAKENHI-PROJECT-20K10152
[Presentation] マルチモーダル鎮痛に用いられる薬物の膜相互作用（Ⅴ）：カプサイシンの濃度依存性膜作用とTRPV-1アンタゴニストのカプサゼピンによる競合的拮抗2022
- Author(s)
  溝上真樹、土屋博紀
- Organizer
  日本麻酔科学会第69回学術集会
- Data Source
  KAKENHI-PROJECT-20K10152
[Presentation] 非ステロイド系抗炎症薬（NSAIDs）は生体膜と相互作用して構造特異的に膜流動性を修飾する2022
- Author(s)
  溝上真樹、飯田宏樹、重見研司、土屋博紀
- Organizer
  第44回日本疼痛学会
- Data Source
  KAKENHI-PROJECT-20K10152
[Presentation] マルチモーダル鎮痛に用いられる薬物の膜相互作用（Ⅳ）：アセトアミノフェンとフェナセチンの有用・有害作用に関する比較2021
- Author(s)
  溝上真樹、土屋博紀、山田宏和、越川桂、畑中奈津実、和泉有希乃
- Organizer
  日本麻酔科学会第68回学術集会
- Data Source
  KAKENHI-PROJECT-20K10152
[Presentation] Medicinal Chemistry of Non-Steroidal Anti-Inflammatory and Antipyretic Drugs: Characterization of Their Interactivity with Lipid Bilayer Membranes2020
- Author(s)
  Maki Mizogami, Hironori Tsuchiya and Kenji Shigemi
- Organizer
  International Congress on Natural Sciences and Engineering 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11924
[Presentation] Medicinal Chemistry of Non-Steroidal Anti-Inflammatory and Antipyretic Drugs: Characterization of Their Interactivity with Lipid Bilayer Membranes.2020
- Author(s)
  Mizogami M, Tsuchiya H
- Organizer
  International Congress on Natural Sciences and Engineering (2020 ICNSE)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10931
[Presentation] マルチモーダル鎮痛に用いられる薬物の膜相互作用（Ⅲ）アセトアミノフェンの機序的膜相互作用2020
- Author(s)
  溝上真樹、土屋博紀、山田宏和、越川桂、竹中志穂
- Organizer
  日本麻酔科学会第67回学術集会
- Data Source
  KAKENHI-PROJECT-20K10152
[Presentation] Membrane interactivity shared by different drugs that act on membrane-associated receptor, ion channel and enzyme: A tool for screening lead compounds2019
- Author(s)
  Hironori Tsuchiya and Maki Mizogami
- Organizer
  18th Edition of International Conference and Exhibition on Pharmaceutics and Novel Drug Delivery Systems
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11924
[Presentation] マルチモーダル鎮痛に用いられる薬物の膜相互作用（Ⅱ）：多様な適応薬が共有する膜流動性修飾作用2019
- Author(s)
  溝上真樹、土屋博紀、畑中奈津実、越川　桂、山田宏和
- Organizer
  日本麻酔科学会第66回学術集会
- Data Source
  KAKENHI-PROJECT-17K11924
[Presentation] Study in Medicinal Chemistry of Receptor-Acting Drugs: Their Membrane Interactivity Specific to Chemical Structures2019
- Author(s)
  Hironori Tsuchiya, Maki Mizogami
- Organizer
  International Congress on Natural Sciences and Engineering (Fukuoka)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11924
[Presentation] Study in medicinal chemistry of receptor-acting drugs: their membrane interactivity specific to chemical structures.2019
- Author(s)
  Tsuchiya H, Mizogami M
- Organizer
  International Congress on Natural Sciences and Engineering (2019 ICNSE)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10931
[Presentation] マルチモーダル鎮痛に用いられる薬物の膜相互作用(Ⅱ): 多様な適応薬が共有する膜流動性修飾用2019
- Author(s)
  溝上真樹、土屋博紀、畑中奈津実、越川　桂、山田宏和
- Organizer
  日本麻酔科学会第66回学術集会
- Data Source
  KAKENHI-PROJECT-16K10931
[Presentation] Membrane Interactivity Shared by Different Drugs That Act on Membrane-Associated Receptor, Ion Channel and Enzyme: A Tool for Screening Lead Compounds.2019
- Author(s)
  Tsuchiya H, Mizogami M
- Organizer
  18th Edition of International Conference and Exhibition on Pharmaceutics and Novel Drug Delivery Systems
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10931
[Presentation] Stereospecific Membrane Interactions of Drug Stereoisomers at Clinically Relavant Concentrations2018
- Author(s)
  H. Tsuchiya, M. Mizogami
- Organizer
  EuroSciCon Conference on Chemistry, Chemistry 2018 (Paris, France)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11924
[Presentation] マルチモーダル鎮痛に用いられる種々の薬物に関する機序的膜作用の特徴2018
- Author(s)
  溝上真樹、土屋博紀、竹内健二、神澤聖一、佐上祐介、重見研司
- Organizer
  日本麻酔科学会第65回学術集会（横浜）
- Data Source
  KAKENHI-PROJECT-17K11924
[Presentation] Structure-Specific Membrane Action of Phytochemicals Responsible for Their Bioactivities2018
- Author(s)
  Hironori Tsuchiya, Maki Mizogami, Kenji Shigemi
- Organizer
  International Symposium on Engineering and Applied Science (Guam)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11924
[Presentation] マルチモーダル鎮痛に用いられる種々の薬物に関する機序的膜作用の特徴2018
- Author(s)
  溝上真樹、土屋博紀、竹内健二、神澤聖一、佐上祐介、重見研司
- Organizer
  日本麻酔科学会第65回学術集会
- Data Source
  KAKENHI-PROJECT-16K10931
[Presentation] Structure-specific membrane action of phytochemicals responsible for their bioactivities.2018
- Author(s)
  Tsuchiya H, Mizogami M, Shigemi K
- Organizer
  International Symposium on Engineering and Applied Science (2018 ISEAS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10931
[Presentation] デクスメデトミジンの機序的膜作用（Ⅲ）：立体異性体の識別に関与する特異的膜部位と膜ステロール構造2017
- Author(s)
  溝上真樹、早渕光代、早渕由朗、重見研司、土屋博紀
- Organizer
  日本麻酔科学会第64回学術集会
- Data Source
  KAKENHI-PROJECT-16K10931
[Presentation] Differentiation of drug stereoisomers by their stereostructure-selective membrane interactions as one of pharmacological mechanisms2017
- Author(s)
  Mizogami　Ｍ, Tsuchiya　Ｈ, Hayabuchi　Ｙ, Shigem　Ｋ．
- Organizer
  19th International Conference on Pharmacology, Medicinal and Pharmaceutical Sciences (ICPMPS 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10931
[Presentation] デクスメデトミジンの機序的膜作用（Ⅲ）：立体異性体の識別に関与する特異的膜部位と膜ステロール構造2017
- Author(s)
  溝上真樹、早渕光代、早渕由朗、重見研司、土屋博紀
- Organizer
  日本麻酔科学会第64回学術集会（神戸）
- Data Source
  KAKENHI-PROJECT-17K11924
[Presentation] Stereospecific Effects of Cholesterol on Membrane Property and Drug Action2017
- Author(s)
  Hironori Tsuchiya, Maki Mizogami, Kenji Shigemi
- Organizer
  International Biotechnology, Chemical Engineering and Life Science Conference (Naha, Okinawa)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11924
[Presentation] Differentiation of Drug Stereoisomers by Their Stereostructure-Selective Membrane Interactions as One of Pharmacological Mechanisms2017
- Author(s)
  Maki Mizogami, Hironori Tsuchiya, Yoshiroh Hayabuchi, Kenji Shigemi
- Organizer
  The 19th International Conference on Pharmacology, Medicinal and Pharmaceutical Sciences (Rome, Italy)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11924
[Presentation] Stereospecific Effects of Cholesterol on Membrane Property and Drug Action2017
- Author(s)
  Tsuchiya　Ｈ, Mizogami　Ｍ, Shigem　Ｋ．
- Organizer
  International Biotechnology, Chemical Engineering and Life Science Conference (2017 IBCELC)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10931
[Presentation] デクスメデトミジンの機序的膜作用（Ⅱ）：脂質組成に依存して立体異性体間で識別できる膜相互作用2016
- Author(s)
  溝上真樹、松木悠佳、重見研司、土屋博紀
- Organizer
  日本麻酔科学会第63回学術集会
- Place of Presentation
  福岡
- Year and Date
  2016-05-26
- Data Source
  KAKENHI-PROJECT-26463078
[Presentation] Interaction of Anesthetic Agents with Neuro-Active Indoleamine-Aldehyde Condensation Products2016
- Author(s)
  Hironori Tsuchiya and Maki Mizogami
- Organizer
  2016 IBCELC International Biotechnology, Chemical Engineering and Life Science Conference
- Place of Presentation
  Naha, Okinawa
- Year and Date
  2016-08-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26463078
[Presentation] Differentiation of Enantiomers for Drug Design: Enantioselective Interactions of Drugs with Chiral Membranes as Their Pharmacological Target2016
- Author(s)
  Hironori Tsuchiya and Maki Mizogami
- Organizer
  10th Drug Design and Medicinal Chemistry Conference
- Place of Presentation
  Berlin, Germany
- Year and Date
  2016-05-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26463078
[Presentation] デクスメデトミジンの機序的膜作用（Ⅱ）：脂質組成に依存して立体異性体間で識別できる膜相互作用2016
- Author(s)
  溝上真樹、松木悠佳、重見研司、土屋博紀
- Organizer
  日本麻酔科学会第63回学術集会
- Place of Presentation
  マリンメッッセ（福岡市）
- Data Source
  KAKENHI-PROJECT-16K10931
[Presentation] Enantiomers of Anesthetic Agents Are Discriminated by Their Interactivity with Chiral Lipid Membranes2016
- Author(s)
  Maki Mizogami, Hironori Tsuchiya and Kenji Shigemi
- Organizer
  16th World Congress of Anaesthesiologists
- Place of Presentation
  Hong Kong
- Year and Date
  2016-08-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26463078
[Presentation] Differentiation of enantiomers for drug design: enantioselective interactions of drugs with chiral membranes as their pharmacological target2016
- Author(s)
  Tsuchiya H, Mizogami M
- Organizer
  10th Drug Design and Medicinal Chemistry Conference
- Place of Presentation
  Berlin, Germany
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10931
[Presentation] Interaction of anesthetic agents with neuro-active indoleamine-aldehyde condensation products.2016
- Author(s)
  Tsuchiya H, Mizogami M
- Organizer
  3rd International Biotechnology, Chemical Engineering and Life Science Conference (IBCELC)
- Place of Presentation
  Okinawa, Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10931
[Presentation] Enantiomers of anesthetic agent are discriminated by their interactivity with chiral lipid.2016
- Author(s)
  Mizogami M, Tsuchiya H, Shigemi K
- Organizer
  16th World Congress of Anaesthesiologists (WCA)
- Place of Presentation
  Hong Kong, China
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10931
[Presentation] DEXMEDETOMIDINE, A SEDATIVE-ANALGESIC ADJUNCT IN ANESTHESIA, ACTS ON LIPID MEMBRANES: ONE OF POSSIBLE MECHANISMS2015
- Author(s)
  M. Mizogami, Y. Matsuki, K. Shigemi, H. Tsuchiya
- Organizer
  IARS 2015 Annual Meeting and International Science Symposium
- Place of Presentation
  Honolulu, Hawaii
- Year and Date
  2015-03-22
- Data Source
  KAKENHI-PROJECT-26463078
[Presentation] Membrane Interaction of Analgesic Agents as Their Mode of Action: A Possible Clue to Discover Drug Leads2015
- Author(s)
  Hironori Tsuchiya and Maki Mizogami
- Organizer
  The 3rd International Scientific Conference on Engineering and Applied Sciences
- Place of Presentation
  Naha, Okinawa
- Year and Date
  2015-07-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26463078
[Presentation] デクスメデトミジンの機序的膜作用：膜脂質二重層との相互作用特性2015
- Author(s)
  松木悠佳、溝上真樹、村上剛、重見研司、土屋博紀
- Organizer
  日本麻酔科学会第62回学術集会
- Place of Presentation
  神戸
- Year and Date
  2015-05-29
- Data Source
  KAKENHI-PROJECT-26463078
[Presentation] ADDITIONAL VALUE OF ANESTHETIC AGENTS IN THE PERIOPERATIVE PERIOD: IN VITRO STUDY OF THEIR COMMON MEMBRANE INTERACTIVITY ASSOCIATED WITH ANTI-OXIDATIVE EFFECTS2015
- Author(s)
  Maki Mizogami, Hironori Tsuchiya and Kenji Shigemi
- Organizer
  The 3rd Singapore-Duke Conference 2015
- Place of Presentation
  Singapore
- Year and Date
  2015-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26463078
[Presentation] 虚血再灌流による局所麻酔薬の心毒性増強：PeroxynitriteとCardiolipinの仮説的関与2014
- Author(s)
  松木悠佳、溝上真樹、重見研司、土屋博紀
- Organizer
  日本麻酔科学会第61回学術集会
- Place of Presentation
  横浜
- Year and Date
  2014-05-17
- Data Source
  KAKENHI-PROJECT-26463078
[Presentation] Relation between Stereostructure and Chiral Lipid Membrane Interactivity of Local Anesthetics2014
- Author(s)
  Hironori Tsuchiya, Maki Mizogami
- Organizer
  The 23rd International Symposium on Medicinal Chemistry
- Place of Presentation
  Lisbon, Portugal
- Year and Date
  2014-09-09
- Data Source
  KAKENHI-PROJECT-26463078
[Presentation] 心毒性発現濃度におけるブピバカインR(+)、ラセミ、S(-)体の立体選択的な脂質膜相互作用2011
- Author(s)
  溝上真樹、土屋博紀、上野高広、高倉康
- Organizer
  日本麻酔科学会第５８回学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23593005
[Presentation] POTENTIAL ANTIOXIDANT UTILITY OF PROPOFOL BEYOND ANESTHESIA ASSOCIATED WITH MEMBRANE INTERACTION : STRUCTURE-ACTIVITY RELATIONSHIP2011
- Author(s)
  H.Tsuchiya, T.Ueno, M.Mizogami
- Organizer
  3^<rd> World Congress of Total Intravenous Anaesthesia & Target Controlled Infusion
- Place of Presentation
  Singapore
- Year and Date
  2011-04-02
- Data Source
  KAKENHI-PROJECT-20592381
[Presentation] STEREOSELECTIVE MEMBRANE INTERACTION OF LOCAL ANESTHETICS AT CARDIOTOXICALLY RELEVANT CONCENTRATIONS: MEMBRANE CHOLESTEROL DETERMINES THE STEREOSELECTIVITY2011
- Author(s)
  M. Mizogami, H. Tsuchiya, T. Ueno, K. Takakura
- Organizer
  IARS 2011 Annual Meeting
- Place of Presentation
  Vancouver
- Data Source
  KAKENHI-PROJECT-23593005
[Presentation] 膜脂質との相互作用に基づく選択的/非選択的β1遮断薬の識別2010
- Author(s)
  溝上真樹, 東康加, 家始聡介, 高倉康, 土屋博紀
- Organizer
  日本麻酔科学会東海・北陸支部第8回学術集会
- Place of Presentation
  福井
- Year and Date
  2010-09-04
- Data Source
  KAKENHI-PROJECT-20592381
[Presentation] STEREOSTRUCTURE-MEMBRANE INTERACTIVITY RELATIONSHIP OF LOCAL ANAESTHETICS ASSOCIATED WITH THEIR STEREOSELECTIVE CARDIOTOXICITY2010
- Author(s)
  Hironori Tsuchiya, Takahiro Ueno, Maki Mizogami, Ko Takakura
- Organizer
  21^<st> International Symposium on Medicinal Chemistry
- Place of Presentation
  Brussels
- Year and Date
  2010-09-06
- Data Source
  KAKENHI-PROJECT-20592381
[Presentation] STRUCTURE-MEMBRANE INTERACTIVITY RELATIONSHIP OF LOCAL ANAESTHETICS ASSOCIATED WITH THEIR STEREOSELECTIVE CARDIOTOXICITY2010
- Author(s)
  Hironori Tsuchiya, Takahiro Ueno, Maki Mizogami, Ko Takakura
- Organizer
  21^<st> International Symposium on Medicinal Chemistry
- Place of Presentation
  Brussels (Belgium)
- Year and Date
  2010-09-06
- Data Source
  KAKENHI-PROJECT-20592381
[Presentation] 局所麻酔薬の立体構造に選択的な心毒性の仮説的機序:ブピバカインならびにロピバカインの立体異性体間で異なるコレステロール生体膜との相互作用2010
- Author(s)
  溝上真樹,上野高広,藤原茂樹,高倉康,土屋博紀
- Organizer
  日本麻酔科学会第57回学術集会
- Place of Presentation
  福岡
- Year and Date
  2010-06-03
- Data Source
  KAKENHI-PROJECT-20592381
[Presentation] 膜脂質との相互作用に基づく選択的/非選択的β_1遮断薬の識別2010
- Author(s)
  溝上真樹,東康加,家始聡介,高倉康,土屋博紀
- Organizer
  日本麻酔科学会東海・北陸支部第8回学術集会
- Place of Presentation
  福井
- Year and Date
  2010-09-04
- Data Source
  KAKENHI-PROJECT-20592381
[Presentation] STEREO-STRUCTURE-MEMBRANE INTERACTIVITY RELATIONSHIP OF LOCAL ANAESTHETICS ASSOCIATED WITH THEIR STEREOSELECTIVE CARDIOTOXICITY2010
- Author(s)
  Hironori Tsuchiya, Takahiko Ueno, Maki Mizogami, Ko Takakura
- Organizer
  21^<st> International Symposium on Medicinal Chemistry
- Place of Presentation
  Brussels
- Year and Date
  2010-09-06
- Data Source
  KAKENHI-PROJECT-20592381
[Presentation] Local anaesthesia affected by inflammation : the conventional mechanism based on tissue acidosis and the novel mechanism focused on inflammatory peroxynitrite2009
- Author(s)
  溝上真樹, 上野高広, 高倉康, 土屋博紀
- Organizer
  12th International Dental Congress on Modern Pain Control
- Place of Presentation
  Gold Coast(Australia)
- Year and Date
  2009-10-17
- Data Source
  KAKENHI-PROJECT-20592381
[Presentation] 局所麻酔薬の構造依存的心毒性に関するカルジオリピンに着目した機序的膜脂質相互作用2009
- Author(s)
  上野高広,溝上真樹,藤原茂樹,高倉康,土屋博紀
- Organizer
  日本麻酔科学会第56回学術集会
- Place of Presentation
  神戸
- Year and Date
  2009-08-16
- Data Source
  KAKENHI-PROJECT-20592381
[Presentation] Local anaesthesia affected by inflammation : the conventional mechanism based on tissue acidosis and the novel mechanism focused on inflammatory peroxynitrite2009
- Author(s)
  Maki Mizogami, Takahiro Ueno, Ko Takakura, Hironori Tsuchiya
- Organizer
  12^<th> International Dental Congress on Modern Pain Control
- Place of Presentation
  Gold Coast
- Year and Date
  2009-10-17
- Data Source
  KAKENHI-PROJECT-20592381
[Presentation] 局所麻酔薬と膜脂質の相互作用からみた麻酔効果と心毒性2008
- Author(s)
  上野高広,溝上真樹,高倉康,土屋博紀
- Organizer
  第30回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  札幌
- Year and Date
  2008-08-07
- Data Source
  KAKENHI-PROJECT-20592381
[Presentation] 選択的／非選択的β１遮断薬の相対的膜相互作用に関する超短時間作用性β１選択的ランジオロールの特性
- Author(s)
  溝上真樹、土屋博紀、上野高広、高倉康、重見研司
- Organizer
  日本麻酔科学会第５９回学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23593005
[Presentation] Stereospecific cardiotoxicity evaluation of local anesthetics using their discriminable interactions with biomimetic chiral membranes
- Author(s)
  Hironori Tsuchiya, Maki Mizogami
- Organizer
  The 49th Congress of the European Societies of Toxicology (EUROTOX 2013)
- Place of Presentation
  Interlaken (Switzerland)
- Data Source
  KAKENHI-PROJECT-23593005
[Presentation] Membrane interactivities are discriminated between selective and nonselective beta1-blockers: characterization of ultra-short-acting highly selective landiolol
- Author(s)
  Mizogami M., Tsuchiya H., Shigemi K.
- Organizer
  Euroanaesthesia 2012, The European Anaesthesiology Congress
- Place of Presentation
  Paris (France)
- Data Source
  KAKENHI-PROJECT-23593005
[Presentation] Plant Components Exhibit Pharmacological Activities and Drug Interactions by Acting on Lipid Membranes
- Author(s)
  Tsuchiya Hironori and Mizogami Maki
- Organizer
  The 3rd International Symposium on Medicinal Plants, Their Cultivation and Aspects of Uses
- Place of Presentation
  Petra (Jordan)
- Data Source
  KAKENHI-PROJECT-23593005
[Presentation] ACTIVITY AND TOXICITY OF ANESTHETIC-ANALGESIC AGENTS IN TERMS OF MEMBRANE INTERACTION AS ONE OF PHARMACOLOGICAL MECHANISMS
- Author(s)
  Hironori Tsuchiya and Maki Mizogami
- Organizer
  The 13th Asian and Oceanic Society of Regional Anesthesia and Pain Medicine Congress
- Place of Presentation
  Bangkok, Thailand
- Year and Date
  2015-01-22 – 2015-01-23
- Data Source
  KAKENHI-PROJECT-26463078
[Presentation] 心毒性をもつ局所麻酔薬の機序的膜相互作用は心筋虚血様酸性条件で増強される
- Author(s)
  松木悠佳、溝上真樹、重見研司、土屋博紀
- Organizer
  日本麻酔科学会第60回学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23593005

1. TSUCHIYA Hironori (30131113)

# of Collaborated Projects: 8 results

# of Collaborated Products: 111 results
2. GOTO Yukio (40079984)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. YANAGIMOTO Masahiro (00191164)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NAKAJIMA Kazuo (20180284)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NAGAYAMA Motohiko (50298436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 坪田恭子 (00197758)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. WAKAMURA Touru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OOSAWA Norito

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 大表良一

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Mizogami Maki 溝上 真樹

MIZOGAMI Maki 溝上 真樹

溝上 真樹 ミゾガミ マキ

Research Projects

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Co-Researchers

生体膜の機序的流動化を基軸とした麻酔薬による抗腫瘍戦略Principal Investigator

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Drug-Selection Standard for Multimodal Analgesia Using Mechanistic Membrane Interactivity Specific to Each Applicable Drug

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Pharmacological diversity of anesthetics is produced by their interactions with chiral biomembranes: mechanistic backgrounds and clinical implications

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A novel pharmacodynamic approach to assess individual differences in anesthetic response: The function of lipids in biological membranePrincipal Investigator

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Novel pharmacodynamic interactions of anesthetics: Anesthetic effects decreased or increased by herbs and supplements in the perioperative period

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Anesthetic effects decreased or increased by the novel pharmacodynamic interactions on biomembrane lipids

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Reverification of the mechanistic membrane effects of anesthetics : Interactions with biomembrane rafts and specific membrane lipids

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The interaction between Mammalian Alkaloids and Anesthetics : Anesthetic Tolerance Associated with Alcohol Drinking and Prediction by Hair Analysis

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除神経骨格筋に対するサクシニルコリン異常反応の研究-31-NMR法を用いて-Principal Investigator

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Trial Product of the Autonomic Nerve Function Analyzable System availed the Fluctuation of the R-R interval variations of ECG

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[Journal Article] Acetaminophen Has Lipid Composition-Dependent Membrane Interactivity That Could be Related to Nephrotoxicity but Not to Analgesic Activity and Hepatotoxicity2022

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[Journal Article] Membrane Interactivity of Capsaicin Antagonized by Capsazepine2022

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[Journal Article] Interaction of drugs with lipid raft membrane domains as a possible target2020

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Mizogami Maki 溝上真樹

MIZOGAMI Maki 溝上真樹

溝上真樹ミゾガミマキ